TDR Targets

Basic information

Technical information

TDR Targets ID: 1414677
Name: 4-[2-[(2-chlorophenyl)methylamino]acetyl]-1,3 -dihydroquinoxalin-2-one; oxalic acid
MW: 419.816 | Formula: C19H18ClN3O6
H donors: 4 H acceptors: 6 LogP: -0.55 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(=O)O.O=C1Nc2ccccc2N(C1)C(=O)CNCc1ccccc1Cl
InChi: 1S/C17H16ClN3O2.C2H2O4/c18-13-6-2-1-5-12(13)9-19-10-17(23)21-11-16(22)20-14-7-3-4-8-15(14)21;3-1(4)2(5)6/h1-8,19H,9-11H2,(H,20,22);(H,3,4)(H,5,6)
InChiKey: RHKNVVQIKDCLOS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[2-[(2-chlorophenyl)methylamino]-1-oxoethyl]-1,3-dihydroquinoxalin-2-one; oxalic acid
4-[2-[(2-chlorobenzyl)amino]acetyl]-1,3-dihydroquinoxalin-2-one; oxalic acid
4-[2-[(2-chlorophenyl)methylamino]ethanoyl]-1,3-dihydroquinoxalin-2-one; ethanedioic acid
T5225250
SMR000348106
MLS001004522

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0127	0.0778
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0043	0.0034	0.2017
Toxoplasma gondii	AtPH1 family protein	0.0041	0.0026	0.1442
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Loa Loa (eye worm)	syntrophin-1	0.0041	0.0026	0.0026
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0041	0.0026	0.0026
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2293	0.8358	0.8358
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.0127	0.0678
Entamoeba histolytica	hypothetical protein	0.0444	0.1517	1
Echinococcus granulosus	oxysterol binding protein 3	0.0041	0.0026	0.0024
Brugia malayi	jmjC domain containing protein	0.0043	0.0033	0.0027
Echinococcus granulosus	Oxysterol binding protein 11	0.0041	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0146	0.0169
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0005	0.0004
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0041	0.0026	0.1442
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Brugia malayi	hypothetical protein	0.0226	0.0711	0.0706
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0041	0.0026	0.0024
Onchocerca volvulus	outspread protein homolog	0.0041	0.0026	0.0112
Schistosoma mansoni	protein kinase	0.0068	0.0127	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Brugia malayi	PXA domain containing protein	0.0444	0.1517	0.1512
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0041	0.0026	0.0024
Brugia malayi	Sema domain containing protein	0.0226	0.0711	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0444	0.1517	0.1516
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.2293	0.8358	1
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Schistosoma mansoni	protein kinase	0.0043	0.0034	0.0033
Entamoeba histolytica	hypothetical protein	0.0052	0.0067	0.0276
Echinococcus multilocularis	regulator of G protein signaling 7	0.0444	0.1517	0.1809
Schistosoma mansoni	serine/threonine-protein kinase	0.0052	0.0067	0.0066
Echinococcus multilocularis	regulator of G protein signaling 3	0.0444	0.1517	0.1809
Schistosoma mansoni	serine/threonine-protein kinase	0.0052	0.0067	0.0066
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.1181	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0041	0.0026	0.0025
Loa Loa (eye worm)	cytohesin 3	0.0041	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Echinococcus granulosus	Pleckstrin y	0.0041	0.0026	0.0024
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0041	0.0026	0.0108
Schistosoma mansoni	plexin	0.0302	0.0992	0.0992
Plasmodium falciparum	PH domain-containing protein, putative	0.0041	0.0026	0.1676
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0041	0.0026	0.0108
Schistosoma mansoni	syntrophin	0.0041	0.0026	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Loa Loa (eye worm)	TK/ALK protein kinase	0.0264	0.0853	0.0853
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0041	0.0026	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0041	0.0026	0.002
Echinococcus multilocularis	cytohesin 1	0.0041	0.0026	0.0024
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2098	0.7636	0.7636
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0019	0.0014
Brugia malayi	Probable exocyst complex component Sec5	0.0099	0.0241	0.0236
Echinococcus granulosus	dynamin 1	0.0041	0.0026	0.0024
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Trypanosoma cruzi	Protein kinase B	0.0052	0.0067	0.408
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0052	0.0067	0.0067
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0009	0.0004
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0067	0.408
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0099	0.0241	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0146	1
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0444	0.1517	0.1516
Entamoeba histolytica	protein kinase domain containing protein	0.0131	0.0359	0.2234
Schistosoma mansoni	dynamin	0.0041	0.0026	0.0025
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0127	0.0127
Brugia malayi	DNA-binding protein LAG-1	0.0099	0.0241	0.0236
Entamoeba histolytica	hypothetical protein	0.0099	0.0241	0.1446
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0043	0.0034	0.0034
Echinococcus granulosus	Pleckstrin y	0.0041	0.0026	0.0024
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0041	0.0026	0.0024
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.1181	0.7749
Brugia malayi	regulator of G-protein signaling rgs-7	0.0444	0.1517	0.1512
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0052	0.0067	0.408
Plasmodium falciparum	oxysterol-binding protein, putative	0.0041	0.0026	0.1676
Entamoeba histolytica	protein kinase , putative	0.0068	0.0127	0.0678
Loa Loa (eye worm)	oxysterol binding protein	0.0041	0.0026	0.0026
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0043	0.0034	0.0802
Echinococcus multilocularis	hypothetical protein	0.0226	0.0711	0.0845
Brugia malayi	hypothetical protein	0.0036	0.0009	0.0004
Echinococcus granulosus	Rho GTPase activating protein 24	0.0041	0.0026	0.0024
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0041	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0302	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0067	0.408
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Entamoeba histolytica	protein kinase, putative	0.0068	0.0127	0.0678
Brugia malayi	Variant SH3 domain containing protein	0.0041	0.0026	0.002
Echinococcus multilocularis	pdz domain containing protein	0.0041	0.0026	0.0024
Onchocerca volvulus		0.0528	0.1828	1
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0041	0.0026	0.0108
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0241	0.0241
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Echinococcus granulosus	regulator of G protein signaling 7	0.0444	0.1517	0.1809
Echinococcus multilocularis	rac serine:threonine kinase	0.0052	0.0067	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Schistosoma mansoni	vav2	0.0041	0.0026	0.0025
Echinococcus multilocularis	roundabout 2	0.0036	0.0009	0.0004
Echinococcus granulosus	aurora kinase A	0.0068	0.0127	0.0145
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0041	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0041	0.0026	0.0024
Brugia malayi	Plexin repeat family protein	0.0528	0.1828	0.1824
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Toxoplasma gondii	hypothetical protein	0.0041	0.0026	0.1442
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0127	0.0126
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.0127	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	rho gtpase activating protein	0.0041	0.0026	0.0025
Schistosoma mansoni	oxysterol-binding protein 1	0.0041	0.0026	0.0025
Echinococcus granulosus	oxysterol binding protein 9	0.0041	0.0026	0.0024
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0052	0.0067	0.3415
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0444	0.1517	0.1516
Trichomonas vaginalis	centaurin gamma, putative	0.0041	0.0026	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	centaurin alpha	0.0041	0.0026	0.0025
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0041	0.0026	0.1676
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0043	0.0034	0.0802
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0043	0.0034	0.0034
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.1181	0.7749
Schistosoma mansoni	protein kinase	0.0043	0.0034	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Entamoeba histolytica	hypothetical protein	0.0099	0.0241	0.1446
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Onchocerca volvulus		0.0226	0.0711	0.3871
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Schistosoma mansoni	regulator of G protein signaling	0.0444	0.1517	0.1516
Schistosoma mansoni	regulator of G protein signaling	0.0444	0.1517	0.1516
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0041	0.0026	0.0024
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0302	0.0355
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0067	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Toxoplasma gondii	aurora kinase	0.0068	0.0127	0.8605
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0041	0.0026	0.002
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0041	0.0026	0.0112
Loa Loa (eye worm)	hypothetical protein	0.006	0.0098	0.0098
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0146	0.0146
Schistosoma mansoni	zinc finger protein	0.0041	0.0026	0.0025
Trichomonas vaginalis	centaurin alpha, putative	0.0041	0.0026	0.0108
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0052	0.0067	0.3415
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0041	0.0026	0.002
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0041	0.0026	0.0026
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0026	0.1676
Brugia malayi	probable spectrin beta chain	0.0041	0.0026	0.002
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0067	0.408
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0041	0.0026	0.0024
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0033	0.0032
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0019	0.0019
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0043	0.0034	0.0802
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Brugia malayi	Uncoordinated protein 104	0.0041	0.0026	0.002
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0127	0.0778
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0052	0.0067	0.408
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0041	0.0026	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0632	0.0632
Echinococcus multilocularis	myotubularin protein 13	0.0041	0.0026	0.0024
Brugia malayi	serine/threonine kinase 12	0.0068	0.0127	0.0121
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0146	0.0146
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0146	0.0169
Trichomonas vaginalis	alpha chimerin, putative	0.0041	0.0026	0.0108
Brugia malayi	Syntrophin-1	0.0041	0.0026	0.002
Echinococcus multilocularis	transcription factor collier	0.0099	0.0241	0.0282
Echinococcus granulosus	activin receptor type	0.0043	0.0034	0.0034
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.0127	0.0145
Echinococcus multilocularis	expressed protein	0.0444	0.1517	0.1809
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0063	0.0109	0.0104
Brugia malayi	Protein kinase domain containing protein	0.0264	0.0853	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Brugia malayi	jmjC domain containing protein	0.0115	0.0302	0.0297
Toxoplasma gondii	hypothetical protein	0.0041	0.0026	0.1442
Brugia malayi	Cadps2 protein	0.0041	0.0026	0.002
Schistosoma mansoni	hypothetical protein	0.0226	0.0711	0.071
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0026	0.1676
Loa Loa (eye worm)	PH domain-containing protein	0.0041	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	goodpasture antigen-binding protein	0.0041	0.0026	0.0025
Plasmodium vivax	PH domain containing protein	0.0041	0.0026	0.1676
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0041	0.0026	0.0108
Echinococcus multilocularis	exocyst complex component 2	0.0099	0.0241	0.0282
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0067	0.408
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Leishmania major	protein kinase, putative	0.0043	0.0034	0.0671
Entamoeba histolytica	p21-activated kinase	0.0052	0.0067	0.0276
Brugia malayi	Plekhf2 protein	0.0041	0.0026	0.002
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0036	0.001	0.0006
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.2098	0.7636	0.7636
Echinococcus granulosus	exocyst complex component 2	0.0099	0.0241	0.0282
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0041	0.0026	0.0024
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0041	0.0026	0.0026
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Schistosoma mansoni	regulator of G protein signaling	0.0444	0.1517	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0032	0.0031
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0052	0.0067	0.408
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0099	0.0241	0.1538
Giardia lamblia	Aurora kinase	0.0068	0.0127	0.1032
Onchocerca volvulus		0.0041	0.0026	0.0112
Schistosoma mansoni	growth factor receptor-bound protein	0.0041	0.0026	0.0025
Echinococcus granulosus	semaphorin 5B	0.0226	0.0711	0.0845
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0052	0.0067	0.0381
Schistosoma mansoni	nephrin	0.0036	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0241	0.0241
Trichomonas vaginalis	protein transport protein sec7, putative	0.0041	0.0026	0.0108
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Leishmania major	serine/threonine-protein kinase a, putative	0.0052	0.0067	0.3415
Loa Loa (eye worm)	hypothetical protein	0.0528	0.1828	0.1828
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0444	0.1517	0.1809
Brugia malayi	Cytohesin 3	0.0041	0.0026	0.002
Entamoeba histolytica	cell surface protease gp63, putative	0.0099	0.0241	0.1446
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0052	0.0067	0.408
Echinococcus granulosus	serine/threonine protein kinase	0.0052	0.0067	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Leishmania major	protein kinase, putative	0.0052	0.0067	0.3415
Echinococcus granulosus	myotubularin protein 13	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Echinococcus granulosus	regulator of G protein signaling 3	0.0444	0.1517	0.1809
Schistosoma mansoni	fibrocystin l	0.0099	0.0241	0.024
Brugia malayi	Dynamin	0.0041	0.0026	0.002
Trypanosoma brucei	protein kinase, putative	0.0052	0.0067	0.408
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus multilocularis	oxysterol binding protein 1	0.0041	0.0026	0.0024
Echinococcus granulosus	regulator of G protein signaling 3	0.0444	0.1517	0.1809
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0052	0.0067	0.408
Echinococcus granulosus	cytohesin 1	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0241	0.0241
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0041	0.0026	0.0108
Loa Loa (eye worm)	Plekhf2 protein	0.0041	0.0026	0.0026
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0444	0.1517	0.1809
Loa Loa (eye worm)	PXA domain-containing protein	0.0444	0.1517	0.1517
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0052	0.0067	0.4365
Entamoeba histolytica	hypothetical protein	0.0099	0.0241	0.1446
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1654	0.5995	0.717
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus multilocularis	aurora kinase A	0.0068	0.0127	0.0145
Plasmodium falciparum	protein kinase, putative	0.0043	0.0034	0.2344
Brugia malayi	Dynamin	0.0041	0.0026	0.002
Brugia malayi	TBC domain containing protein	0.0041	0.0026	0.002
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2737	1	1
Echinococcus multilocularis	axis inhibition protein axin	0.0444	0.1517	0.1809
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0041	0.0026	0.0024
Brugia malayi	hypothetical protein	0.0041	0.0026	0.002
Echinococcus granulosus	oxysterol binding protein 1	0.0041	0.0026	0.0024
Entamoeba histolytica	hypothetical protein	0.0444	0.1517	1
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0052	0.0067	0.5072
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0052	0.0067	0.5072
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0041	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Onchocerca volvulus		0.0041	0.0026	0.0112
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0043	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.0513	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0052	0.0067	0.4365
Brugia malayi	PXA domain containing protein	0.0444	0.1517	0.1512
Brugia malayi	Fibronectin type III domain containing protein	0.0036	0.0009	0.0004
Echinococcus multilocularis	plexin a4	0.0627	0.2195	0.2621
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0041	0.0026	0.1676
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0067	0.408
Schistosoma mansoni	hypothetical protein	0.0226	0.0711	0.071
Loa Loa (eye worm)	plexin A	0.0627	0.2195	0.2195
Schistosoma mansoni	oxysterol-binding protein 1	0.0041	0.0026	0.0025
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0056	0.0061
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0052	0.0067	0.408
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0041	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	myotubularin-related protein	0.0041	0.0026	0.0025
Onchocerca volvulus	Putative zinc finger protein	0.0041	0.0026	0.0112
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0033	0.0033
Schistosoma mansoni	cell adhesion molecule	0.0036	0.0009	0.0008
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Schistosoma mansoni	ephrin receptor	0.0036	0.001	0.0009
Toxoplasma gondii	Oxysterol-binding protein	0.0041	0.0026	0.1442
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0009	0.0009
Echinococcus multilocularis	Oxysterol binding protein 11	0.0041	0.0026	0.0024
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0041	0.0026	0.1676
Onchocerca volvulus		0.0041	0.0026	0.0112
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0444	0.1517	0.1512
Brugia malayi	regulator of G-protein signaling egl-10	0.0444	0.1517	0.1512
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0041	0.0026	0.0024
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Echinococcus granulosus	DCC interacting protein 13 beta	0.0041	0.0026	0.0024
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0302	0.0355
Echinococcus multilocularis	semaphorin 5B	0.0226	0.0711	0.0845
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Echinococcus multilocularis	Pleckstrin y	0.0041	0.0026	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0041	0.0026	0.0024
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0099	0.0241	0.1538
Onchocerca volvulus		0.0041	0.0026	0.0112
Schistosoma mansoni	semaphorin 5-related	0.0226	0.0711	0.071
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Leishmania major	protein kinase, putative	0.0052	0.0067	0.3415
Echinococcus granulosus	pdz domain containing protein	0.0041	0.0026	0.0024
Echinococcus multilocularis	regulator of G protein signaling	0.0444	0.1517	0.1809
Loa Loa (eye worm)	rho-GTPase-activating	0.0041	0.0026	0.0026
Schistosoma mansoni	axis inhibition protein axin	0.0444	0.1517	0.1516
Schistosoma mansoni	serine/threonine protein kinase	0.2737	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0025
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.0127	0.0121
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Echinococcus granulosus	Regulator of G protein signaling 20	0.0444	0.1517	0.1809
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Echinococcus multilocularis	regulator of G protein signaling 3	0.0444	0.1517	0.1809
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0019	0.0016
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus granulosus	beta-adrenergic receptor kinase	0.2098	0.7636	0.9135
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0067	0.408
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.0127	0.0127
Echinococcus granulosus	beta 1 syntrophin	0.0041	0.0026	0.0024
Echinococcus granulosus	transcription factor collier	0.0099	0.0241	0.0282
Trichomonas vaginalis	centaurin/arf, putative	0.0041	0.0026	0.0108
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0032	0.0031
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0099	0.0241	0.1538
Leishmania major	folate/biopterin transporter, putative	0.0052	0.0067	0.3415
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0052	0.0067	0.0381
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0444	0.1517	0.1517
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0444	0.1517	0.1809
Brugia malayi	A-kinase anchor protein 10, precursor	0.0444	0.1517	0.1512
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.0127	1
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0005	0.0005
Brugia malayi	Sema domain containing protein	0.0226	0.0711	0.0706
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0144	0.0144
Trichomonas vaginalis	kinesin light chain, putative	0.0041	0.0026	0.0108
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0041	0.0026	0.0024
Brugia malayi	IPT/TIG domain containing protein	0.0099	0.0241	0.0236
Schistosoma mansoni	zinc finger protein	0.0041	0.0026	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Loa Loa (eye worm)	RGS-3 protein	0.0444	0.1517	0.1517
Echinococcus multilocularis	oxysterol binding protein 9	0.0041	0.0026	0.0024
Entamoeba histolytica	tyrosin kinase, putative	0.0131	0.0359	0.2234
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0033	0.0032
Echinococcus granulosus	GRB2 associated binding protein 3	0.0041	0.0026	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0127	0.0778
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0052	0.0067	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus granulosus	twitchin	0.0043	0.0033	0.0033
Schistosoma mansoni	regulator of G protein signaling	0.0444	0.1517	0.1516
Echinococcus granulosus	axis inhibition protein axin	0.0444	0.1517	0.1809
Leishmania major	protein kinase, putative	0.0068	0.0127	0.8369
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2098	0.7636	0.9135
Echinococcus granulosus	plexin a4	0.0627	0.2195	0.2621
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Loa Loa (eye worm)	hypothetical protein	0.0302	0.0992	0.0992
Brugia malayi	Pleckstrin Homology Domain	0.0041	0.0026	0.002
Trypanosoma brucei	aurora B kinase	0.0068	0.0127	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0099	0.0241	0.1538
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0033	0.0033
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.0513	1
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0052	0.0067	0.408
Echinococcus multilocularis	actin binding protein anillin	0.0041	0.0026	0.0024
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.0127	0.0678
Onchocerca volvulus		0.0041	0.0026	0.0112
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.0513	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Echinococcus multilocularis	axis inhibition protein axin	0.0444	0.1517	0.1809
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.1181	0.5
Schistosoma mansoni	regulator of G protein signaling	0.0444	0.1517	0.1516
Entamoeba histolytica	protein kinase domain containing protein	0.0043	0.0034	0.0054
Echinococcus granulosus	axis inhibition protein axin	0.0444	0.1517	0.1809
Entamoeba histolytica	hypothetical protein	0.0444	0.1517	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Schistosoma mansoni	serine/threonine protein kinase	0.2098	0.7636	0.7636
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0052	0.0067	0.408
Echinococcus granulosus	semaphorin 1A	0.0226	0.0711	0.0845
Trypanosoma cruzi	NIMA-related kinase, putative	0.0052	0.0067	0.408
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.0127	1
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Onchocerca volvulus		0.0041	0.0026	0.0112
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0041	0.0026	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0226	0.0711	0.0711
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Entamoeba histolytica	hypothetical protein	0.0052	0.0067	0.0276
Trypanosoma brucei	protein kinase, putative	0.0043	0.0034	0.0802
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.0127	0.0678
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0127	0.0778
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0214	0.0213
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1654	0.5995	0.717
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0241	0.0241
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0019	0.0016
Schistosoma mansoni	hypothetical protein	0.0035	0.0005	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0009	0.0009
Entamoeba histolytica	protein kinase, putative	0.0052	0.0067	0.0276
Echinococcus granulosus	regulator of G protein signaling 7	0.0444	0.1517	0.1809
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.2293	0.8358	1
Brugia malayi	MAX-1A	0.0041	0.0026	0.002
Echinococcus multilocularis	Pleckstrin y	0.0041	0.0026	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus granulosus	calcium dependent secretion activator 1	0.0041	0.0026	0.0024
Schistosoma mansoni	hypothetical protein	0.0041	0.0026	0.0025
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0036	0.001	0.0006
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.0127	0.0678
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0041	0.0026	0.0025
Onchocerca volvulus	Protein melted homolog	0.0041	0.0026	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0026	0.0026
Entamoeba histolytica	hypothetical protein	0.0099	0.0241	0.1446
Echinococcus granulosus	expressed protein	0.0444	0.1517	0.1809
Schistosoma mansoni	hypothetical protein	0.0099	0.0241	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0444	0.1517	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0041	0.0026	0.0108
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.0127	0.0145
Echinococcus multilocularis	oxysterol binding protein 3	0.0041	0.0026	0.0024
Brugia malayi	hypothetical protein	0.0226	0.0711	0.0706
Echinococcus multilocularis	Pleckstrin y	0.0041	0.0026	0.0024
Schistosoma mansoni	axis inhibition protein axin	0.0444	0.1517	0.1516
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0041	0.0026	0.1676
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0041	0.0026	0.0024
Schistosoma mansoni	z-protein (S1r protein)	0.0444	0.1517	0.1516
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.2293	0.8358	0.8358
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0041	0.0026	0.1676
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.2293	0.8358	0.8358
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Trichomonas vaginalis	centaurin beta, putative	0.0041	0.0026	0.0108
Schistosoma mansoni	hypothetical protein	0.0099	0.0241	0.024
Onchocerca volvulus		0.0041	0.0026	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0005	0.0005
Brugia malayi	Variant SH3 domain containing protein	0.0041	0.0026	0.002
Echinococcus multilocularis	beta 1 syntrophin	0.0041	0.0026	0.0024
Loa Loa (eye worm)	uncoordinated protein 104	0.0041	0.0026	0.0026
Schistosoma mansoni	plexin	0.0528	0.1828	0.1828
Echinococcus multilocularis	activin receptor type	0.0043	0.0034	0.0034
Loa Loa (eye worm)	sema domain-containing protein	0.0226	0.0711	0.0711
Trichomonas vaginalis	protein transport protein sec7, putative	0.0041	0.0026	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Entamoeba histolytica	protein kinase, putative	0.0068	0.0127	0.0678
Echinococcus multilocularis	regulator of G protein signaling 7	0.0444	0.1517	0.1809
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0108
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0444	0.1517	1
Echinococcus multilocularis	dynamin 1	0.0041	0.0026	0.0024
Schistosoma mansoni	goodpasture antigen-binding protein	0.0041	0.0026	0.0025
Loa Loa (eye worm)	sema domain-containing protein	0.0226	0.0711	0.0711
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0033	0.0033
Schistosoma mansoni	dynamin	0.0041	0.0026	0.0025
Echinococcus granulosus	Pleckstrin y	0.0041	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Brugia malayi	hypothetical protein	0.0444	0.1517	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0444	0.1517	0.1517
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0056	0.0061
Schistosoma mansoni	protein kinase	0.0043	0.0034	0.0033
Brugia malayi	Oxysterol binding protein	0.0041	0.0026	0.002
Echinococcus granulosus	roundabout 2	0.0036	0.0009	0.0004
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Brugia malayi	plexin A	0.0627	0.2195	0.219
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.1181	0.7773
Trichomonas vaginalis	centaurin/arf, putative	0.0041	0.0026	0.0108
Brugia malayi	PH domain containing protein	0.0041	0.0026	0.002
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0041	0.0026	0.0024
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0146	1
Echinococcus granulosus	pleckstrin y domain containing family A	0.0041	0.0026	0.0024
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0063	0.0109	0.0109
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0041	0.0026	0.0024
Trichomonas vaginalis	AGC family protein kinase	0.0052	0.0067	0.0381
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0241	0.1538
Brugia malayi	Oxysterol-binding protein	0.0041	0.0026	0.002
Trichomonas vaginalis	hypothetical protein	0.0041	0.0026	0.0108
Brugia malayi	hypothetical protein	0.0444	0.1517	0.1512
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0052	0.0067	0.408
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0041	0.0026	0.0024
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0444	0.1517	0.1512

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 19.9054 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1549474

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1414677