Detailed information for compound 1415139

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 663.683 | Formula: C25H29N9O9S2
  • H donors: 5 H acceptors: 12 LogP: -0.45 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@H](c1ccc(cc1)O)C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)CSc1nnnn1C.O
  • InChi: 1S/C25H27N9O8S2.H2O/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);1H2/t15-,16-,22-;/m1./s1
  • InChiKey: HRRMBILIWABKRK-WERGMSTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0465 0.5581
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0008 0.0015
Loa Loa (eye worm) Smad1 0.0025 0.0012 0.0022
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0038 0.0074
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0297 0.0585
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0056 0.0085
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.063 0.063
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0088
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0297 0.0585
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0042 0.0116 0.0212
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0181 0.0235
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0012 0.0012
Loa Loa (eye worm) DR-78 0.0025 0.0008 0.0015
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0152 0.0809 0.1052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0375 0.0574
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.048 0.0943
Loa Loa (eye worm) carboxylesterase 0.0025 0.0012 0.0022
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.005 0.0091
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0224 1
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0181 0.0181
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.005 0.0091
Mycobacterium leprae Probable lipase LipE 0.0071 0.0297 0.2948
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0031 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.012 0.022
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0173 0.034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0567 0.1116
Echinococcus granulosus lysine specific histone demethylase 1A 0.0063 0.025 0.0325
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0088
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0038 0.0069
Plasmodium falciparum amino acid transporter, putative 0.0152 0.0809 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0181 0.0329
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0647 0.1272
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0152 0.0809 0.1241
Brugia malayi conserved hypotetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.026 0.0399
Echinococcus granulosus smad 0.0025 0.0012 0.0016
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.012 0.099
Loa Loa (eye worm) hypothetical protein 0.0112 0.0559 0.102
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0008 0.0015
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.063 0.115
Echinococcus multilocularis protein patched 0.0042 0.0116 0.0116
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0483 0.0741
Echinococcus granulosus nAChR subunit 0.0031 0.005 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0181 0.0329
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Onchocerca volvulus 0.0102 0.0495 0.089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.01 0.048 0.0875
Plasmodium falciparum transporter, putative 0.0152 0.0809 1
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0181 0.0315
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Onchocerca volvulus Alhambra homolog 0.0066 0.0265 0.047
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.005 0.0091
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0265 0.301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0035 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.005 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0181 0.0277
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Loa Loa (eye worm) RNA binding protein 0.0129 0.0663 0.1209
Brugia malayi P38 map kinase family protein 2 0.0124 0.063 0.115
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0224 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0181 0.0329
Echinococcus multilocularis 0.0063 0.025 0.025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0526
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0567
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0224 0.044
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0181 0.0235
Treponema pallidum sodium- and chloride- dependent transporter 0.0898 0.5482 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0297 0.0387
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus dihydrofolate reductase 0.0043 0.012 0.0157
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0663 0.1209
Brugia malayi hypothetical protein 0.0025 0.0012 0.0022
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0012 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0198 0.256
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0102 0.0495 0.0903
Brugia malayi nuclear receptor NHR-88 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Brugia malayi Dihydrofolate reductase 0.0043 0.012 0.022
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.005 0.0065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0008 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.0703 0.1283
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0008 0.001
Brugia malayi PHD-finger family protein 0.0028 0.0028 0.005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0181 0.0181
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0181 0.0235
Echinococcus granulosus tar DNA binding protein 0.0129 0.0663 0.0861
Schistosoma mansoni amine oxidase 0.0063 0.025 0.0384
Echinococcus granulosus muscleblind protein 0.0145 0.0763 0.0992
Mycobacterium ulcerans beta-lactamase 0.0071 0.0297 0.0543
Brugia malayi nuclear hormone receptor 0.0052 0.0181 0.0329
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0834 0.5085 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0026 0.0041
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Toxoplasma gondii hypothetical protein 0.0152 0.0809 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0567 0.1116
Loa Loa (eye worm) hypothetical protein 0.01 0.0483 0.0882
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Loa Loa (eye worm) hypothetical protein 0.0102 0.0495 0.0903
Brugia malayi Bromodomain containing protein 0.004 0.0105 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.015 0.0791 0.1213
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0088
Schistosoma mansoni sodium/chloride dependent transporter 0.0152 0.0809 0.1241
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0031 0.04
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0181 0.0277
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0008 0.0008
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.005 0.005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.004 0.0106 0.0193
Schistosoma mansoni nuclear receptor 0.0025 0.0008 0.0012
Brugia malayi hypothetical protein 0.0152 0.0809 0.1476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Brugia malayi follicle stimulating hormone receptor 0.0297 0.1713 0.3125
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0647 0.6815
Mycobacterium ulcerans lipase LipD 0.0071 0.0297 0.0543
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0038 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.1597 0.2076
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0008 0.0015
Loa Loa (eye worm) ACC-1 protein 0.0031 0.005 0.0091
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.0774 0.9547
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0167 0.0304
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.005 0.0091
Brugia malayi Cation transporter family protein 0.0031 0.005 0.0091
Onchocerca volvulus Putative nachr subunit 0.0031 0.005 0.0077
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0152 0.0809 0.1476
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0181 0.0181
Plasmodium falciparum protoporphyrinogen oxidase 0.0063 0.025 0.2817
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0647 0.1272
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.005 0.0065
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.009 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0092 0.043 0.0784
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.148 0.2701
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0181 0.0329
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.005 0.0065
Schistosoma mansoni eyes absent homolog 0.0092 0.043 0.0659
Echinococcus multilocularis muscleblind protein 0.0145 0.0763 0.0763
Leishmania major hypothetical protein, conserved 0.0071 0.0297 0.3843
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0173 0.1821
Onchocerca volvulus 0.0898 0.5482 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Brugia malayi CXXC zinc finger family protein 0.0029 0.0035 0.0063
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0173 0.0173
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.0507 0.0998
Plasmodium vivax amine transporter, putative 0.0152 0.0809 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0012 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0181 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0297 0.0456
Brugia malayi SWIRM domain containing protein 0.0063 0.025 0.0456
Schistosoma mansoni sodium/chloride dependent transporter 0.0898 0.5482 0.8406
Brugia malayi hypothetical protein 0.0028 0.0026 0.0048
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0038 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0181 0.0277
Echinococcus multilocularis acetylcholinesterase 0.015 0.0791 0.0791
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0038 0.0182
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0116 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0181 0.0329
Brugia malayi hypothetical protein 0.0055 0.0198 0.0361
Schistosoma mansoni ap endonuclease 0.0059 0.0224 0.0343
Echinococcus granulosus lysine specific histone demethylase 1A 0.0063 0.025 0.0325
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0198 0.2149
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0038 0.0086
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0012 0.0016
Plasmodium falciparum phd finger protein, putative 0.0066 0.0265 0.301
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Onchocerca volvulus 0.0031 0.005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.063 0.063
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0038 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.053 0.0967
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Schistosoma mansoni sodium/chloride dependent transporter 0.0153 0.0812 0.1245
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0116 0.0151
Brugia malayi tailless protein 0.0025 0.0008 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0063 0.025 0.2817
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0181 0.0329
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0063 0.025 0.2817
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0173 0.1821
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0181 0.0329
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0055 0.0198 0.0361
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0181 0.0329
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.063 0.082
Echinococcus multilocularis geminin 0.1064 0.6521 0.6521
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2688 0.5286
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0465 0.0465
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0038 0.0038
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0012 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0278 0.1597 0.2913
Schistosoma mansoni hypothetical protein 0.0411 0.243 0.3726
Plasmodium vivax SET domain protein, putative 0.0098 0.0465 0.5581
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2067 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.01 0.048 0.0943
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0075 0.0321 0.0632
Brugia malayi thymidylate synthase 0.0104 0.0507 0.0926
Brugia malayi CHE-14 protein 0.0042 0.0116 0.0212
Onchocerca volvulus 0.0025 0.0012 0.0008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0008 0.0008
Echinococcus granulosus acetylcholinesterase 0.015 0.0791 0.1029
Loa Loa (eye worm) hypothetical protein 0.0115 0.0577 0.1053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0224 0.0408
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.0577 0.075
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Leishmania major trypanothione reductase 0.005 0.0167 0.2153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0181 0.0235
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.012 0.012
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0898 0.5481 1
Brugia malayi Cation transporter family protein 0.0031 0.005 0.0091
Brugia malayi nuclear receptor NHR-67 0.0025 0.0008 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0173 0.0315
Plasmodium vivax acyl-CoA synthetase, putative 0.0075 0.0321 0.3732
Schistosoma mansoni patched 1 0.0042 0.0116 0.0179
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0297 0.0585
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.2177 0.3971
Brugia malayi nuclear receptor RXR 0.0028 0.0026 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0265 0.0484
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Loa Loa (eye worm) beta-lactamase 0.0071 0.0297 0.0543
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0483 0.0882
Brugia malayi TAR-binding protein 0.0129 0.0663 0.1209
Onchocerca volvulus 0.0029 0.0035 0.0049
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0773 0.0773
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0063 0.025 0.2817
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Brugia malayi Bromodomain containing protein 0.008 0.0356 0.065
Mycobacterium ulcerans thymidylate synthase 0.0104 0.0507 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0297 0.3843
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0288 0.0526
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Brugia malayi hypothetical protein 0.005 0.0165 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Echinococcus granulosus sodium and chloride dependent glycine 0.0152 0.0809 0.1052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.012 0.0237
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0898 0.5482 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0031 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0233 0.0426
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0181 0.0277
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Mycobacterium ulcerans monoamine oxidase 0.0063 0.025 0.0456
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0022
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Echinococcus granulosus cpg binding protein 0.0032 0.0058 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0466 0.0605
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0224 0.0291
Brugia malayi nuclear hormone receptor 0.0025 0.0008 0.0015
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0256 0.0256
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0224 0.1082
Loa Loa (eye worm) carboxylesterase 0.0025 0.0012 0.0022
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0297 0.1713 0.3125
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0008 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.01 0.048 0.0875
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0038 0.0086
Loa Loa (eye worm) carboxylesterase 0.015 0.0791 0.1443
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0181 0.0329
Echinococcus multilocularis neuroligin 0.0025 0.0012 0.0012
Echinococcus multilocularis acetylcholinesterase 0.015 0.0791 0.0791
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0316 0.0576
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0224 0.2888
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0224 0.0478
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni dihydrofolate reductase 0.0043 0.012 0.0185
Echinococcus granulosus carboxylesterase 5A 0.015 0.0791 0.1029
Onchocerca volvulus 0.0031 0.005 0.0077
Echinococcus multilocularis smad 0.0025 0.0012 0.0012
Onchocerca volvulus 0.01 0.0483 0.0868
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0008 0.001
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0297 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0567 0.1116
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 0.9547
Schistosoma mansoni coup transcription factor 0.0052 0.0181 0.0277
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.008
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0935 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni acetylcholinesterase 0.0025 0.0012 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0167 0.2153
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0224 0.0353
Loa Loa (eye worm) hypothetical protein 0.015 0.0791 0.1443
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0224 0.2888
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0769 0.4678 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0475 0.0729
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0375 0.0683
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0012 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.005 0.005
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0167 0.0167
Brugia malayi nuclear receptor RXR 0.0025 0.0008 0.0015
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Mycobacterium tuberculosis Carboxylesterase LipT 0.0025 0.0012 0.0024
Onchocerca volvulus 0.0025 0.0012 0.0008
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.012 0.022
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0063 0.025 0.2817
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0224 0.2475
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.048 0.2321
Schistosoma mansoni ap endonuclease 0.0059 0.0224 0.0343
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0008 0.001
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0663 0.1209
Toxoplasma gondii ABC1 family protein 0.0071 0.0297 0.3424
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.063 0.063
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0063 0.025 0.0384
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Onchocerca volvulus 0.0063 0.025 0.0442
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.01 0.048 0.0875
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0152 0.0809 0.0809
Echinococcus multilocularis thymidylate synthase 0.0104 0.0507 0.0507
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0152 0.0809 1
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0165 0.0324
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.243 0.243
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0038 0.0069
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0472
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0152 0.0809 0.1052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Loa Loa (eye worm) hypothetical protein 0.0428 0.254 0.4634
Onchocerca volvulus 0.0052 0.0181 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0465 0.0713
Onchocerca volvulus 0.0029 0.0038 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.005 0.0091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0979 0.2092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0297 0.0585
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0224 0.2475
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0173 0.0265
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0483 0.0628
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0012 0.0024
Echinococcus granulosus neuroligin 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0088 0.0405 0.0738
Brugia malayi Cation transporter family protein 0.0102 0.0495 0.0903
Echinococcus multilocularis jumonji domain containing protein 0.0091 0.0426 0.0426
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0352 0.0352
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0181 0.0315
Mycobacterium ulcerans dehydrogenase 0.0063 0.025 0.0456
Echinococcus multilocularis PHD finger protein rhinoceros 0.0066 0.0265 0.0265
Onchocerca volvulus 0.0031 0.005 0.0077
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Mycobacterium tuberculosis Possible oxidoreductase 0.0063 0.025 0.0492
Brugia malayi nuclear receptor NHR-88 0.0025 0.0008 0.0015
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0012 0.0012
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Brugia malayi beta-lactamase 0.0071 0.0297 0.0543
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Echinococcus multilocularis cpg binding protein 0.0032 0.0058 0.0058
Onchocerca volvulus 0.0071 0.0297 0.0529
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0066 0.0265 0.0407
Schistosoma mansoni hypothetical protein 0.0066 0.0265 0.0407
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0026 0.0034
Echinococcus granulosus PHD finger protein rhinoceros 0.0066 0.0265 0.0345
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0069
Echinococcus multilocularis neuropeptide s receptor 0.0556 0.3338 0.3338
Loa Loa (eye worm) ACC-1 protein 0.0031 0.005 0.0091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0012 0.0019
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0031 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0763 0.0763
Brugia malayi dihydrofolate reductase family protein 0.0043 0.012 0.022
Echinococcus granulosus expressed conserved protein 0.0092 0.0429 0.0557
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0234 0.2615
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.009 0.009
Schistosoma mansoni amine oxidase 0.0063 0.025 0.0384
Brugia malayi beta-lactamase family protein 0.0071 0.0297 0.0543
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0038 0.0049
Brugia malayi hypothetical protein 0.0063 0.025 0.0456
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Echinococcus multilocularis sodium and chloride dependent glycine 0.0152 0.0809 0.0809
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0008 0.001
Toxoplasma gondii hypothetical protein 0.0152 0.0809 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.063 0.8144
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Onchocerca volvulus 0.0071 0.0297 0.0529
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0663 0.0663
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0173 0.2231
Onchocerca volvulus 0.01 0.048 0.0862
Chlamydia trachomatis protoporphyrinogen oxidase 0.0063 0.025 0.2817
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0167 0.0328
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0297 0.2948
Plasmodium falciparum glutathione reductase 0.005 0.0167 0.1744
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0647 0.1272
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0038 0.0086
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0773 0.1186
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.0065
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0063 0.025 0.2817
Echinococcus granulosus neuropeptide receptor A26 0.0556 0.3338 0.4341
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0008 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.005 0.0065
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0075 0.0321 0.3732
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0165 0.0352
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0008 0.0015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.0577 0.0577
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0063 0.025 0.2426
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0181 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0008 0.001
Onchocerca volvulus 0.0102 0.0495 0.089
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0466 0.2253
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0567 0.1116
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0152 0.0809 0.1052
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.005 0.0091
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0224 0.0408
Echinococcus granulosus Smad4 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0181 0.0329
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0074 0.0316 0.0576
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0088
Brugia malayi Pre-SET motif family protein 0.0676 0.4093 0.7466
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0181 0.0181
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.01 0.048 0.0875
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0108 0.053 0.0967
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Loa Loa (eye worm) norepinephrine transporter 0.0898 0.5482 1
Brugia malayi hypothetical protein 0.0035 0.0076 0.0139
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0008 0.0015
Brugia malayi Smad1 0.0025 0.0012 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0063 0.025 0.0456
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0663 0.1209
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0181 0.0277
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0979 0.2092
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.008
Echinococcus granulosus Solute carrier family 22 5 0.125 0.7691 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0173 0.0315
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0065 0.0261 0.2959
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Schistosoma mansoni hypothetical protein 0.0074 0.0316 0.0485
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.0507 0.5272
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0288 0.0288
Brugia malayi Carboxylesterase family protein 0.015 0.0791 0.1443
Echinococcus multilocularis peregrin 0.0068 0.0281 0.0281
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5078 0.7787
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0181 0.0277
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0167 0.1744
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0466 0.0849
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0038 0.0069
Echinococcus multilocularis Smad4 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0145 0.0763 0.1391
Brugia malayi Thioredoxin reductase 0.005 0.0167 0.0304
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0012 0.0016
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0935 0.1706
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0921 0.1668
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Onchocerca volvulus 0.0025 0.0012 0.0008
Loa Loa (eye worm) solute carrier family 6 member 4 0.0898 0.5482 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0224 0.1082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Brugia malayi Bromodomain containing protein 0.0068 0.0281 0.0512
Echinococcus granulosus sodium and chloride dependent glycine 0.0152 0.0809 0.1052
Echinococcus granulosus dnaJ subfamily B 0.0411 0.243 0.316
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0038 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Brugia malayi steroid hormone receptor 0.0052 0.0181 0.0329
Echinococcus multilocularis expressed conserved protein 0.0092 0.0429 0.0429
Echinococcus granulosus jumonji domain containing protein 0.0091 0.0426 0.0554
Mycobacterium tuberculosis Probable reductase 0.0114 0.0567 0.1116
Brugia malayi MH2 domain containing protein 0.037 0.2177 0.3971
Onchocerca volvulus 0.0102 0.0495 0.089
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.005 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0173 0.1821
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0152 0.0809 0.1052
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0181 0.0277
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Leishmania major hypothetical protein, conserved 0.0055 0.0198 0.256
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0297 0.0543
Mycobacterium ulcerans carboxylesterase, LipT 0.0025 0.0012 0.0022
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0022
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0483 0.0483
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0773 0.1006
Loa Loa (eye worm) LGC-31 protein 0.0031 0.005 0.0091
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0567 0.5934
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0038 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Schistosoma mansoni hypothetical protein 0.0147 0.0773 0.1186
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.2177 0.3971
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.005
Onchocerca volvulus 0.0029 0.0038 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0181 0.0329
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0224 0.0224
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0898 0.5481 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2067 1
Entamoeba histolytica acyl-coA synthetase, putative 0.01 0.048 0.2321
Echinococcus multilocularis serotonin transporter 0.0898 0.5482 0.5482
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0031 0.04
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0181 0.0235
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.048 0.4964
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.005 0.005
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Brugia malayi hypothetical protein 0.0092 0.043 0.0784
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0297 0.0297
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0297 0.3424
Onchocerca volvulus 0.0071 0.0297 0.0529
Brugia malayi PHD-finger family protein 0.0025 0.0011 0.002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0152 0.0809 0.1241
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0181 0.0329
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0063 0.025 0.0384
Echinococcus granulosus GPCR family 2 0.0034 0.0068 0.0088
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0215 0.1201 0.1201
Schistosoma mansoni hypothetical protein 0.1064 0.6521 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.005 0.0065
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2067 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.048 0.2321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Brugia malayi Pre-SET motif family protein 0.0098 0.0465 0.0849
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.005 0.0065
Brugia malayi jmjC domain containing protein 0.0083 0.0375 0.0683
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Echinococcus granulosus thymidylate synthase 0.0104 0.0507 0.066
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.053 0.0967
Brugia malayi RNA binding protein 0.0129 0.0663 0.1209
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0297 0.0456
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0038 0.0058
Brugia malayi hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.025 0.0492
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0181 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0181 0.0329
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0567 0.1116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Echinococcus granulosus neuropeptide s receptor 0.0556 0.3338 0.4341
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0809 1
Onchocerca volvulus 0.0152 0.0809 0.1464
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0069
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0012 0.0012
Echinococcus multilocularis sodium and chloride dependent glycine 0.0152 0.0809 0.0809
Schistosoma mansoni smad 0.0025 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0008 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.012 0.115
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0121 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0265 0.301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0068
Schistosoma mansoni Smad4 0.0025 0.0012 0.0019
Brugia malayi PHD-finger family protein 0.0066 0.0265 0.0484
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0288 0.0375
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0165 0.2129
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.063 0.082
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0012 0.0012
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0092 0.043 0.0784
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0012 0.0022
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0026 0.0041
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0181 0.0277
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0181 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.053 0.0967
Brugia malayi isocitrate dehydrogenase 0.0051 0.0173 0.0315
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0038 0.0069
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0173 0.1821
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0225
Schistosoma mansoni gliotactin 0.0025 0.0012 0.0019
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.005 0.0091
Mycobacterium ulcerans hypothetical protein 0.0071 0.0297 0.0543
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0484
Loa Loa (eye worm) hypothetical protein 0.0098 0.0466 0.0849
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.0465 0.0713
Echinococcus granulosus peregrin 0.0068 0.0281 0.0365
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0022
Entamoeba histolytica hypothetical protein 0.0028 0.0031 0.015
Giardia lamblia PHD finger protein 15 0.0066 0.0265 0.1283
Loa Loa (eye worm) glutathione reductase 0.005 0.0167 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0008 0.0008
Onchocerca volvulus 0.0769 0.4678 0.8531
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0728 0.0728
Plasmodium falciparum thioredoxin reductase 0.005 0.0167 0.1744
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0466 0.0466
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5078 0.5078
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.148 0.2701
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0224 0.2888
Onchocerca volvulus 0.0152 0.0809 0.1464
Echinococcus granulosus lysine specific demethylase 5A 0.0083 0.0375 0.0487
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0297 0.0636
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0278 0.1597 0.2913
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Schistosoma mansoni bromodomain containing protein 0.0068 0.0279 0.0428
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Trypanosoma brucei trypanothione reductase 0.005 0.0167 0.2153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Trypanosoma cruzi UDP-galactopyranose mutase 0.0063 0.025 0.3232
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0181 0.0277
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0297 0.0585
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0297 0.0636
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0116 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0181 0.0329
Toxoplasma gondii exonuclease III APE 0.0059 0.0224 0.2475
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0012 0.0016
Schistosoma mansoni hypothetical protein 0.1064 0.6521 1
Loa Loa (eye worm) thymidylate synthase 0.0104 0.0507 0.0926
Brugia malayi hypothetical protein 0.0025 0.0008 0.0015
Plasmodium vivax glutathione reductase, putative 0.005 0.0167 0.1744
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0898 0.5482 0.8406
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0152 0.0809 0.0809
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0068 0.0124
Plasmodium vivax hypothetical protein, conserved 0.0063 0.025 0.2817
Onchocerca volvulus 0.0029 0.0038 0.0054
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0116 0.0116
Brugia malayi beta-lactamase family protein 0.0071 0.0297 0.0543
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Trichomonas vaginalis esterase, putative 0.0071 0.0297 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.1597 0.2076
Echinococcus multilocularis protoporphyrinogen oxidase 0.0063 0.025 0.025
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0013
Onchocerca volvulus 0.0025 0.0012 0.0008
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0181 0.0315
Echinococcus multilocularis nAChR subunit 0.0031 0.005 0.005
Leishmania major UDP-galactopyranose mutase 0.0063 0.025 0.3232
Loa Loa (eye worm) hypothetical protein 0.0428 0.254 0.4634
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Trypanosoma cruzi UDP-galactopyranose mutase 0.0063 0.025 0.3232
Toxoplasma gondii thioredoxin reductase 0.005 0.0167 0.1744
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0198 0.256
Schistosoma mansoni cpg binding protein 0.0029 0.0035 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0068
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0288 0.0442
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0038 0.0074
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2067 0.3735
Loa Loa (eye worm) oxidoreductase 0.0029 0.0038 0.0069
Brugia malayi glutathione reductase 0.005 0.0167 0.0304
Echinococcus multilocularis neuropeptide receptor A26 0.0556 0.3338 0.3338
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Mycobacterium ulcerans hypothetical protein 0.01 0.048 0.0875
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0526
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0577 0.0885
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0224 0.0478
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.015 0.0791 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0116 0.0249
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.005 0.0091
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.0507 0.0778
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0297 0.3843
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0181 0.0277
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0181 0.0329
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0012 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0577 0.0885
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0181 0.0329
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.0069
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0181 0.0329
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0038 0.0069
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.005 0.0065
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.005 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0181 0.0329
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0063 0.025 0.025
Onchocerca volvulus 0.0025 0.0012 0.0008
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0181 0.0181
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0068 0.0124
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0078 0.0143
Echinococcus multilocularis carboxylesterase 5A 0.015 0.0791 0.0791
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0012 0.0016
Onchocerca volvulus 0.0098 0.0465 0.0835
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0439 0.0571
Onchocerca volvulus 0.0034 0.0067 0.0108
Brugia malayi ecdysone receptor 0.0025 0.0008 0.0015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0676 0.4093 0.7466
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0009 0.0012
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.005 0.0065
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.0495 0.0759
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.0495 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0375 0.0574
Brugia malayi hypothetical protein 0.0147 0.0773 0.1411
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0012 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Brugia malayi Muscleblind-like protein 0.0145 0.0763 0.1391
Schistosoma mansoni jumonji domain containing protein 0.0171 0.0924 0.1417
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0068 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Echinococcus multilocularis protein dispatched 1 0.0048 0.0154 0.0154
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0181 0.0181
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus multilocularis GPCR, family 2 0.0034 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0038 0.0086
Schistosoma mansoni sodium-dependent amino acid transporter 0.0152 0.0809 0.1241
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0297 0.0585
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0321 0.0586
Brugia malayi jmjC domain containing protein 0.0215 0.1201 0.2191
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0012 0.0019
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5078 0.6603
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0012 0.0016
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Echinococcus granulosus serotonin transporter 0.0898 0.5482 0.7128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0297 0.0543
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0215 0.1201 0.1562
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0297 0.0585
Schistosoma mansoni zinc finger protein 0.0025 0.0008 0.0012
Plasmodium falciparum acyl-CoA synthetase 0.0075 0.0321 0.3732
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0008 0.0015
Onchocerca volvulus 0.0152 0.0809 0.1464
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0728 0.0947
Brugia malayi amine oxidase, flavin-containing family protein 0.0063 0.025 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus granulosus acetylcholinesterase 0.015 0.0791 0.1029
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0038 0.0069
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0297 0.3843
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0297 0.0543
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.063 0.063
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0152 0.0809 0.0809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.1597 0.1597
Loa Loa (eye worm) acetylcholinesterase 1 0.015 0.0791 0.1443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.1597 0.1597
Schistosoma mansoni nuclear receptor 0.0025 0.0008 0.0012
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0008 0.0008
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0167 0.0217
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0181 0.0181
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0224 0.2888
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Mycobacterium ulcerans oxidoreductase 0.0063 0.025 0.0456
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0008 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Loa Loa (eye worm) hypothetical protein 0.0145 0.0763 0.1391
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0265 0.301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0181 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0181 0.0277
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 0.9547
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0008 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0074 0.0318 0.058
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.048 0.4964
Echinococcus granulosus geminin 0.1064 0.6521 0.848
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0935 0.1838
Toxoplasma gondii histone lysine-specific demethylase 0.0063 0.025 0.2817
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0181 0.0329
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0198 0.256
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Onchocerca volvulus 0.0104 0.0507 0.0912
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0256 0.0333
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0038 0.0074
Brugia malayi Cytochrome P450 family protein 0.0061 0.0233 0.0426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0263
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0288 0.3724
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0038 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0181 0.0329
Loa Loa (eye worm) serotonin transporter b 0.0898 0.5482 1
Brugia malayi Carboxylesterase family protein 0.015 0.0791 0.1443
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.005 0.005
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.0052 0.0181 0.0329
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Brugia malayi hypothetical protein 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.005 0.0091
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0008 0.0015
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0173 0.2231

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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