TDR Targets

Basic information

Technical information

TDR Targets ID: 1415358
Name: 2-(1,3-benzodioxol-5-ylmethyl)-3-hydroxy-3H-i soindol-1-one
MW: 283.279 | Formula: C16H13NO4
H donors: 1 H acceptors: 2 LogP: 1.71 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1c2ccccc2C(N1Cc1ccc2c(c1)OCO2)O
InChi: 1S/C16H13NO4/c18-15-11-3-1-2-4-12(11)16(19)17(15)8-10-5-6-13-14(7-10)21-9-20-13/h1-7,15,18H,8-9H2
InChiKey: ULTIGFCSUSNWJU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(1,3-benzodioxol-5-ylmethyl)-3-hydroxy-isoindolin-1-one
2-(1,3-benzodioxol-5-ylmethyl)-3-hydroxy-1-isoindolinone
SMR000093904
STK041971
MLS000116950

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0073	0.0077	0.006
Loa Loa (eye worm)	TK/ACK protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0232	0.0232
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.0029	0.0154
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0077	0.5981
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.079	0.1561	0.1546
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	beta-lactamase	0.0043	0.0017	0.0006
Echinococcus granulosus	regulator of G protein signaling 3	0.079	0.1561	0.1855
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.008	0.0092	0.041
Plasmodium falciparum	serine/threonine protein kinase, putative	0.008	0.0092	0.7113
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Schistosoma mansoni	hypothetical protein	0.0073	0.0077	0.006
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0118	1
Trichomonas vaginalis	AGC family protein kinase	0.008	0.0092	0.0557
Echinococcus granulosus	protein tyrosine kinase	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0077	0.5981
Echinococcus granulosus	tyrosine kinase	0.0049	0.0029	0.0022
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0049	0.0029	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0049	0.0029	0.0022
Trypanosoma cruzi	aurora B kinase, putative	0.008	0.0092	0.7458
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0017	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0049	0.0029	0.0022
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0049	0.0029	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.008	0.0092	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0118	0.0107
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0073	0.0077	0.0079
Schistosoma mansoni	regulator of G protein signaling	0.079	0.1561	0.1546
Onchocerca volvulus		0.0049	0.0029	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0049	0.0029	0.0154
Onchocerca volvulus		0.0049	0.0029	0.0181
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0049	0.0029	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Toxoplasma gondii	aurora kinase	0.008	0.0092	0.7458
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0092	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	twitchin	0.01	0.0134	0.0147
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0.007	0.5213
Brugia malayi	regulator of G-protein signaling egl-10	0.079	0.1561	0.1551
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0073	0.0077	0.5981
Onchocerca volvulus		0.0073	0.0077	0.0488
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0049	0.0029	0.0018
Echinococcus multilocularis	integrin linked protein kinase	0.0049	0.0029	0.0022
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Giardia lamblia	Aurora kinase	0.008	0.0092	1
Leishmania major	folate/biopterin transporter, putative	0.0092	0.0118	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Cadps2 protein	0.0073	0.0077	0.0066
Brugia malayi	Oxysterol binding protein	0.0073	0.0077	0.0066
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0073	0.0077	0.0488
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0073	0.0077	0.0462
Entamoeba histolytica	hypothetical protein	0.0073	0.0077	0.0314
Entamoeba histolytica	hypothetical protein	0.0092	0.0118	0.0577
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3736	0.7648	0.914
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Entamoeba histolytica	cell surface protease gp63, putative	0.0147	0.0232	0.1322
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0073	0.0077	0.0077
Onchocerca volvulus	outspread protein homolog	0.0073	0.0077	0.0488
Echinococcus granulosus	oxysterol binding protein 3	0.0073	0.0077	0.0079
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0042	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Entamoeba histolytica	hypothetical protein	0.0073	0.0077	0.0314
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0054	0.004	0.0034
Echinococcus granulosus	tyrosine protein kinase	0.0049	0.0029	0.0022
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0049	0.0029	0.0022
Echinococcus multilocularis	regulator of G protein signaling 7	0.079	0.1561	0.1855
Onchocerca volvulus		0.0073	0.0077	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Echinococcus granulosus	defective proboscis extension response	0.008	0.0094	0.0099
Onchocerca volvulus	Protein melted homolog	0.0073	0.0077	0.0488
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Echinococcus granulosus	tyrosine protein kinase HCK	0.0049	0.0029	0.0022
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0077	0.0066
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	protein kinase domain containing protein	0.0196	0.0334	0.1987
Brugia malayi	Guanylyl cyclase protein 23	0.0049	0.0029	0.0018
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0118	1
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0073	0.0077	0.0079
Echinococcus granulosus	tyrosine protein kinase shark	0.0049	0.0029	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Onchocerca volvulus		0.0791	0.1561	1
Onchocerca volvulus		0.0049	0.0029	0.0181
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Trypanosoma brucei	aurora B kinase	0.008	0.0092	0.7458
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0029	0.0012
Entamoeba histolytica	hypothetical protein	0.0073	0.0077	0.0314
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.008	0.0092	0.0097
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Brugia malayi	Cytohesin 3	0.0073	0.0077	0.0066
Trichomonas vaginalis	STE family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Schistosoma mansoni	protein kinase	0.008	0.0092	0.0075
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0147	0.0232	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0077	0.0077
Loa Loa (eye worm)	SRC-1	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.0029	0.0018
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0092	0.0118	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0077	0.006
Brugia malayi	C-terminal src kinase protein 1	0.0049	0.0029	0.0018
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0049	0.0029	0.1194
Schistosoma mansoni	axis inhibition protein axin	0.079	0.1561	0.1546
Schistosoma mansoni	syntrophin	0.0073	0.0077	0.006
Brugia malayi	Receptor family ligand binding region containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	hypothetical protein	0.079	0.1561	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0049	0.0029	0.0022
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus granulosus	Pleckstrin y	0.0073	0.0077	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Toxoplasma gondii	Oxysterol-binding protein	0.0073	0.0077	0.5981
Schistosoma mansoni	ephrin receptor	0.0054	0.004	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0049	0.0029	0.0029
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Brugia malayi	Dynamin	0.0073	0.0077	0.0066
Onchocerca volvulus		0.0049	0.0029	0.0181
Echinococcus multilocularis	transcription factor collier	0.0147	0.0232	0.0264
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus granulosus	tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0017	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Toxoplasma gondii	protein kinase	0.0049	0.0029	0.1194
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0092	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Brugia malayi	hypothetical protein	0.0336	0.0622	0.0612
Loa Loa (eye worm)	TK/EPH protein kinase	0.0049	0.0029	0.0029
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0049	0.0029	0.0022
Echinococcus multilocularis	tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0049	0.0029	0.0022
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0049	0.0029	0.1194
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0073	0.0077	0.0079
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0049	0.0029	0.0012
Echinococcus multilocularis	myotubularin protein 13	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trichomonas vaginalis	centaurin alpha, putative	0.0073	0.0077	0.0462
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0049	0.0029	0.0022
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0073	0.0077	0.0462
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.079	0.1561	1
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Echinococcus multilocularis	oxysterol binding protein 9	0.0073	0.0077	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.008	0.0094	0.0076
Schistosoma mansoni	vesicular amine transporter	0.0083	0.0099	0.0082
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0049	0.0029	0.0022
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0073	0.0077	0.5436
Loa Loa (eye worm)	sema domain-containing protein	0.0336	0.0622	0.0622
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0073	0.0077	0.5981
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0104	0.0104
Brugia malayi	DNA-binding protein LAG-1	0.0147	0.0232	0.0221
Onchocerca volvulus		0.0043	0.0017	0.0104
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Echinococcus multilocularis	hypothetical protein	0.0336	0.0622	0.0731
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	hypothetical protein	0.0147	0.0232	0.0215
Brugia malayi	A-kinase anchor protein 10, precursor	0.079	0.1561	0.1551
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Loa Loa (eye worm)	PH domain-containing protein	0.0073	0.0077	0.0077
Entamoeba histolytica	hypothetical protein	0.0147	0.0232	0.1322
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0017	0.0077
Entamoeba histolytica	protein kinase, putative	0.008	0.0092	0.041
Brugia malayi	Oxysterol-binding protein	0.0073	0.0077	0.0066
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0049	0.0029	0.0022
Echinococcus granulosus	regulator of G protein signaling 7	0.079	0.1561	0.1855
Onchocerca volvulus		0.0049	0.0029	0.0181
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0073	0.0077	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Onchocerca volvulus		0.0073	0.0077	0.0488
Echinococcus granulosus	calcium dependent secretion activator 1	0.0073	0.0077	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.008	0.0092	0.0557
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0073	0.0077	0.5981
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	zinc finger protein	0.0073	0.0077	0.006
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	Plekhf2 protein	0.0073	0.0077	0.0066
Trichomonas vaginalis	AGC family protein kinase	0.008	0.0092	0.0557
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0073	0.0077	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0077	0.006
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Loa Loa (eye worm)	TK/Met protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0049	0.0029	0.0022
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus granulosus	ephrin type A receptor 4 A	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0073	0.0077	0.0079
Echinococcus granulosus	Pleckstrin y	0.0073	0.0077	0.0079
Leishmania major	protein kinase, putative	0.0092	0.0118	1
Echinococcus multilocularis	actin binding protein anillin	0.0073	0.0077	0.0079
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0791	0.1561	0.1561
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus granulosus	semaphorin 1A	0.0336	0.0622	0.0731
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	protein kinase	0.0049	0.0029	0.0022
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.008	0.0094	0.0099
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0073	0.0077	0.0077
Entamoeba histolytica	protein kinase domain containing protein	0.008	0.0092	0.041
Entamoeba histolytica	p21-activated kinase	0.0092	0.0118	0.0577
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Brugia malayi	serine/threonine kinase 12	0.008	0.0092	0.0081
Schistosoma mansoni	goodpasture antigen-binding protein	0.0073	0.0077	0.006
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.013	0.0195	0.0195
Echinococcus granulosus	expressed protein	0.079	0.1561	0.1855
Echinococcus granulosus	roundabout 2	0.0085	0.0104	0.0111
Schistosoma mansoni	hypothetical protein	0.0073	0.0077	0.006
Plasmodium falciparum	PH domain-containing protein, putative	0.0073	0.0077	0.5436
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0073	0.0077	0.5981
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0049	0.0029	0.0154
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trypanosoma brucei	protein kinase, putative	0.0092	0.0118	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0042	0.0037
Echinococcus granulosus	activated cdc42 kinase 1	0.0049	0.0029	0.0022
Trypanosoma brucei	PH domain containing protein, putative	0.0073	0.0077	0.5981
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trichomonas vaginalis	centaurin gamma, putative	0.0073	0.0077	0.0462
Echinococcus granulosus	Oxysterol binding protein 11	0.0073	0.0077	0.0079
Schistosoma mansoni	plexin	0.0791	0.1561	0.1547
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Echinococcus granulosus	insulin receptor	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0073	0.0077	0.0079
Echinococcus multilocularis	tyrosine protein kinase shark	0.0049	0.0029	0.0022
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0017	0.0008
Brugia malayi	Furin-like cysteine rich region family protein	0.0049	0.0029	0.0018
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0017	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Onchocerca volvulus		0.0049	0.0029	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Onchocerca volvulus		0.0043	0.0017	0.0104
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0049	0.0029	0.0022
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0073	0.0077	0.0462
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0029	0.0012
Onchocerca volvulus		0.0049	0.0029	0.0181
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0049	0.0029	0.0154
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0042	0.0031
Echinococcus granulosus	beta 1 syntrophin	0.0073	0.0077	0.0079
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0073	0.0077	0.0066
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0118	1
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0092	0.0118	0.0721
Schistosoma mansoni	semaphorin 5-related	0.0336	0.0622	0.0606
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0049	0.0029	0.0018
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0073	0.0077	0.5436
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Onchocerca volvulus		0.0049	0.0029	0.0181
Echinococcus multilocularis	neuroglian	0.008	0.0094	0.0099
Echinococcus multilocularis	Immunoglobulin	0.008	0.0094	0.0099
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0077	0.0066
Echinococcus granulosus	transcription factor collier	0.0147	0.0232	0.0264
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Loa Loa (eye worm)	TK/ALK protein kinase	0.0305	0.0558	0.0558
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0118	1
Loa Loa (eye worm)	cytohesin 3	0.0073	0.0077	0.0077
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus multilocularis	tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	rho-GTPase-activating	0.0073	0.0077	0.0077
Echinococcus multilocularis	exocyst complex component 2	0.0147	0.0232	0.0264
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0147	0.0232	0.1455
Leishmania major	protein kinase, putative	0.0069	0.007	0.5213
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	hypothetical protein	0.0092	0.0118	0.0577
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	regulator of G protein signaling 3	0.079	0.1561	0.1855
Brugia malayi	TBC domain containing protein	0.0073	0.0077	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	TK/DDR protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Echinococcus granulosus	exocyst complex component 2	0.0147	0.0232	0.0264
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0017	0.0077
Echinococcus multilocularis	tyrosine protein kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.008	0.0092	0.041
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0073	0.0077	0.0077
Onchocerca volvulus		0.0049	0.0029	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0042	0.0024
Echinococcus multilocularis	regulator of G protein signaling 3	0.079	0.1561	0.1855
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0049	0.0029	0.0022
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0502	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0049	0.0029	0.0022
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0049	0.0029	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus multilocularis	oxysterol binding protein 3	0.0073	0.0077	0.0079
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0049	0.0029	0.0022
Echinococcus multilocularis	protein kinase	0.0049	0.0029	0.0022
Onchocerca volvulus		0.0073	0.0077	0.0488
Plasmodium falciparum	oxysterol-binding protein, putative	0.0073	0.0077	0.5436
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0073	0.0077	0.0079
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0049	0.0029	0.0018
Echinococcus multilocularis	expressed protein	0.079	0.1561	0.1855
Echinococcus granulosus	serine/threonine protein kinase	0.0092	0.0118	0.0128
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.4084	0.8367	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Brugia malayi	Tyrosine-protein kinase PR2	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.079	0.1561	0.1855
Loa Loa (eye worm)	PXA domain-containing protein	0.079	0.1561	0.1561
Trichomonas vaginalis	AGC family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	hypothetical protein	0.079	0.1561	0.1551
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.008	0.0094	0.0099
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Brugia malayi	hypothetical protein	0.0085	0.0104	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	cytohesin 1	0.0073	0.0077	0.0079
Echinococcus multilocularis	oxysterol binding protein 1	0.0073	0.0077	0.0079
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Trichomonas vaginalis	alpha chimerin, putative	0.0073	0.0077	0.0462
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0.007	0.5213
Echinococcus granulosus	semaphorin 5B	0.0336	0.0622	0.0731
Trichomonas vaginalis	protein kinase atn1, putative	0.0049	0.0029	0.0154
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Loa Loa (eye worm)	TK/RYK protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Variant SH3 domain containing protein	0.0073	0.0077	0.0066
Echinococcus granulosus	tyrosine protein kinase pr2	0.0049	0.0029	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Leishmania major	hypothetical protein, conserved	0.0073	0.0077	0.5981
Brugia malayi	Pleckstrin Homology Domain	0.0073	0.0077	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	hypothetical protein	0.0073	0.0077	0.0462
Brugia malayi	Syntrophin-1	0.0073	0.0077	0.0066
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0073	0.0077	0.5981
Plasmodium vivax	PH domain containing protein	0.0073	0.0077	0.5981
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0073	0.0077	0.0462
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0049	0.0029	0.0022
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0092	0.0118	1
Brugia malayi	Sema domain containing protein	0.0336	0.0622	0.0612
Schistosoma mansoni	z-protein (S1r protein)	0.079	0.1561	0.1546
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus granulosus	raf serine:threonine protein kinase	0.0049	0.0029	0.0022
Schistosoma mansoni	serine/threonine protein kinase	0.3736	0.7648	0.7644
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	Pleckstrin y	0.0073	0.0077	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	pleckstrin y domain containing family A	0.0073	0.0077	0.0079
Brugia malayi	ephrin receptor 1 precursor	0.0049	0.0029	0.0018
Echinococcus granulosus	activin receptor type	0.0069	0.007	0.007
Echinococcus multilocularis	protein tyrosine kinase	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Brugia malayi	beta-lactamase family protein	0.0043	0.0017	0.0006
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0073	0.0077	0.0079
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0042	0.0037
Onchocerca volvulus		0.0073	0.0077	0.0488
Trypanosoma brucei	Pseudokinase, putative	0.0049	0.0029	0.1194
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0017	0.5
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.4084	0.8367	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0042	0.0042
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	cell adhesion molecule	0.0085	0.0104	0.0087
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0054	0.004	0.0034
Loa Loa (eye worm)	sema domain-containing protein	0.0336	0.0622	0.0622
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0092	0.0118	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Brugia malayi	beta-lactamase family protein	0.0043	0.0017	0.0006
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0019	0.0001
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0049	0.0029	0.0012
Echinococcus multilocularis	heat shock protein 70	0.0049	0.0029	0.0022
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0049	0.0029	0.0029
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	oxysterol binding protein 1	0.0073	0.0077	0.0079
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0073	0.0077	0.0314
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0049	0.0029	0.0022
Schistosoma mansoni	axis inhibition protein axin	0.079	0.1561	0.1546
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.079	0.1561	0.1546
Echinococcus granulosus	tyrosine protein kinase Srms	0.0049	0.0029	0.0022
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0049	0.0029	0.0022
Brugia malayi	Dynamin	0.0073	0.0077	0.0066
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Loa Loa (eye worm)	serine/threonine protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0049	0.0029	0.0022
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Brugia malayi	Probable exocyst complex component Sec5	0.0147	0.0232	0.0221
Trichomonas vaginalis	esterase, putative	0.0043	0.0017	0.0077
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0069	0.007	0.007
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0073	0.0077	0.006
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0049	0.0029	0.0022
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0147	0.0232	0.1455
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.0029	0.0012
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0077	0.5436
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0073	0.0077	0.5436
Echinococcus granulosus	natriuretic peptide receptor 1	0.0049	0.0029	0.0022
Echinococcus multilocularis	semaphorin 5B	0.0336	0.0622	0.0731
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Toxoplasma gondii	protein kinase domain-containing protein	0.0049	0.0029	0.1194
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	c src tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0147	0.0232	0.1455
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus granulosus	Regulator of G protein signaling 20	0.079	0.1561	0.1855
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0049	0.0029	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	protein transport protein sec7, putative	0.0073	0.0077	0.0462
Echinococcus granulosus	protein kinase	0.0049	0.0029	0.0022
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0049	0.0029	0.0022
Loa Loa (eye worm)	TK/ROR protein kinase	0.0049	0.0029	0.0029
Leishmania major	serine/threonine-protein kinase a, putative	0.0092	0.0118	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0069	0.007	0.5213
Schistosoma mansoni	serine/threonine RGC	0.0049	0.0029	0.0012
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.008	0.0092	0.7458
Trypanosoma cruzi	protein kinase, putative	0.0049	0.0029	0.1194
Entamoeba histolytica	hypothetical protein	0.0073	0.0077	0.0314
Loa Loa (eye worm)	TK/FAK protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	Regulator of G protein signaling 20	0.079	0.1561	0.1855
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0049	0.0029	0.0022
Brugia malayi	hypothetical protein	0.0049	0.0029	0.0018
Echinococcus multilocularis	plexin a4	0.0938	0.1865	0.2219
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0.007	0.0263
Brugia malayi	hypothetical protein	0.0073	0.0077	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0092	0.0118	1
Echinococcus granulosus	DCC interacting protein 13 beta	0.0073	0.0077	0.0079
Brugia malayi	protein-tyrosine kinase	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Onchocerca volvulus		0.0049	0.0029	0.0181
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0017	0.0077
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0092	0.0118	1
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trypanosoma cruzi	Protein kinase B	0.0092	0.0118	1
Schistosoma mansoni	hypothetical protein	0.0336	0.0622	0.0606
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0077	0.5981
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0049	0.0029	0.0022
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0085	0.0104	0.0093
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0049	0.0029	0.0022
Schistosoma mansoni	serine/threonine-protein kinase	0.0092	0.0118	0.01
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0073	0.0077	0.0079
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0049	0.0029	0.0018
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0073	0.0077	0.0079
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0073	0.0077	0.0462
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	regulator of G protein signaling	0.079	0.1561	0.1546
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	axis inhibition protein axin	0.079	0.1561	0.1855
Loa Loa (eye worm)	AUR protein kinase	0.008	0.0092	0.0092
Echinococcus multilocularis	insulin receptor	0.0049	0.0029	0.0022
Schistosoma mansoni	rho gtpase activating protein	0.0073	0.0077	0.006
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Entamoeba histolytica	hypothetical protein	0.0147	0.0232	0.1322
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0073	0.0077	0.0079
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.079	0.1561	0.1546
Leishmania major	hypothetical protein, conserved	0.0049	0.0029	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus granulosus	kinase suppressor of Ras 1	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Brugia malayi	Uncoordinated protein 104	0.0073	0.0077	0.0066
Onchocerca volvulus		0.0049	0.0029	0.0181
Brugia malayi	PXA domain containing protein	0.079	0.1561	0.1551
Leishmania major	hypothetical protein, conserved	0.0073	0.0077	0.5981
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0017	0.0017
Echinococcus granulosus	Rho GTPase activating protein 24	0.0073	0.0077	0.0079
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.4084	0.8367	0.8367
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0077	0.5981
Loa Loa (eye worm)	TK/INSR protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.4084	0.8367	0.8365
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0232	0.0232
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0077	0.0314
Schistosoma mansoni	protein kinase	0.0069	0.007	0.0052
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0073	0.0077	0.0079
Onchocerca volvulus	Putative zinc finger protein	0.0073	0.0077	0.0488
Echinococcus multilocularis	Oxysterol binding protein 11	0.0073	0.0077	0.0079
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0049	0.0029	0.0029
Schistosoma mansoni	ephrin receptor	0.0049	0.0029	0.0012
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Echinococcus multilocularis	regulator of G protein signaling 7	0.079	0.1561	0.1855
Onchocerca volvulus		0.0049	0.0029	0.0181
Brugia malayi	hypothetical protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Brugia malayi	Plexin repeat family protein	0.0791	0.1561	0.1552
Entamoeba histolytica	hypothetical protein	0.0073	0.0077	0.0314
Trypanosoma cruzi	hypothetical protein	0.0073	0.0077	0.5981
Schistosoma mansoni	regulator of G protein signaling	0.079	0.1561	0.1546
Brugia malayi	Sema domain containing protein	0.0336	0.0622	0.0612
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0077	0.0314
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0077	0.0079
Schistosoma mansoni	growth factor receptor-bound protein	0.0073	0.0077	0.006
Echinococcus granulosus	axis inhibition protein axin	0.079	0.1561	0.1855
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Echinococcus granulosus	epidermal growth factor receptor	0.0049	0.0029	0.0022
Toxoplasma gondii	hypothetical protein	0.0073	0.0077	0.5981
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2946	0.6015	0.7186
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0049	0.0029	0.1194
Brugia malayi	Immunoglobulin I-set domain containing protein	0.013	0.0195	0.0185
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0049	0.0029	0.0022
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	receptor type guanylyl cyclase	0.0049	0.0029	0.0022
Schistosoma mansoni	protein kinase	0.0069	0.007	0.0052
Brugia malayi	Raf kinase	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0042	0.0037
Echinococcus multilocularis	activated cdc42 kinase 1	0.0049	0.0029	0.0022
Loa Loa (eye worm)	AUR protein kinase	0.008	0.0092	0.0092
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0073	0.0077	0.0066
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.079	0.1561	0.1561
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4084	0.8367	0.8367
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0017	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0073	0.0077	0.006
Echinococcus granulosus	pdz domain containing protein	0.0073	0.0077	0.0079
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Onchocerca volvulus		0.0049	0.0029	0.0181
Brugia malayi	Fibronectin type III domain containing protein	0.0085	0.0104	0.0093
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	myotubularin protein 13	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0049	0.0029	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0049	0.0029	0.0181
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Echinococcus multilocularis	beta 1 syntrophin	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Schistosoma mansoni	hypothetical protein	0.0073	0.0077	0.006
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0092	0.0118	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0069	0.007	0.007
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0017	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Schistosoma mansoni	dynamin	0.0073	0.0077	0.006
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0077	0.0077
Echinococcus granulosus	axis inhibition protein axin	0.079	0.1561	0.1855
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0118	1
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0049	0.0029	0.0022
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Trypanosoma cruzi	PH domain containing protein, putative	0.0073	0.0077	0.5981
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0069	0.007	0.007
Entamoeba histolytica	PH domain containing protein	0.0073	0.0077	0.0314
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Trichomonas vaginalis	AGC family protein kinase	0.008	0.0092	0.0557
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	serine/threonine-protein kinase	0.0092	0.0118	0.01
Echinococcus granulosus	dynamin 1	0.0073	0.0077	0.0079
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Echinococcus multilocularis	rac serine:threonine kinase	0.0092	0.0118	0.0128
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	Regulator of G protein signaling domain containing protein	0.079	0.1561	0.1551
Schistosoma mansoni	plexin	0.0455	0.0867	0.0851
Echinococcus multilocularis	dynamin 1	0.0073	0.0077	0.0079
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0092	0.0118	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.079	0.1561	1
Loa Loa (eye worm)	hypothetical protein	0.0455	0.0867	0.0867
Brugia malayi	regulator of G-protein signaling rgs-7	0.079	0.1561	0.1551
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	pdz domain containing protein	0.0073	0.0077	0.0079
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3736	0.7648	0.7648
Leishmania major	protein kinase, putative	0.008	0.0092	0.7458
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0049	0.0029	0.0012
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0049	0.0029	0.0022
Onchocerca volvulus		0.0073	0.0077	0.0488
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0049	0.0029	0.0022
Schistosoma mansoni	hypothetical protein	0.0455	0.0867	0.0851
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0305	0.0558	0.0548
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trypanosoma cruzi	protein kinase, putative	0.0049	0.0029	0.1194
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.008	0.0094	0.0076
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0069	0.007	0.5213
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0017	0.5
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	hypothetical protein	0.0147	0.0232	0.0215
Brugia malayi	integrin-linked kinase	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0077	0.0314
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0049	0.0029	0.0022
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0073	0.0077	0.0079
Schistosoma mansoni	fibrocystin l	0.0147	0.0232	0.0215
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	nephrin	0.0085	0.0104	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0104	0.0104
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Entamoeba histolytica	PH domain containing protein	0.0073	0.0077	0.0314
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0092	0.0118	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0049	0.0029	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0092	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	Immunoglobulin	0.008	0.0094	0.0099
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0092	0.0118	0.0118
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0017	0.0077
Trichomonas vaginalis	TK family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0077	0.0314
Leishmania major	protein kinase, putative	0.0092	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0049	0.0029	0.0022
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.079	0.1561	0.1855
Schistosoma mansoni	protein kinase	0.0069	0.007	0.0052
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0232	0.0232
Schistosoma mansoni	centaurin alpha	0.0073	0.0077	0.006
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0049	0.0029	0.1194
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0077	0.0079
Entamoeba histolytica	protein kinase, putative	0.008	0.0092	0.041
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Loa Loa (eye worm)	uncoordinated protein 104	0.0073	0.0077	0.0077
Entamoeba histolytica	hypothetical protein	0.0147	0.0232	0.1322
Trichomonas vaginalis	centaurin beta, putative	0.0073	0.0077	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0225	0.0393	0.0393
Echinococcus multilocularis	axis inhibition protein axin	0.079	0.1561	0.1855
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0073	0.0077	0.0314
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0092	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Entamoeba histolytica	hypothetical protein, conserved	0.0073	0.0077	0.0314
Brugia malayi	hypothetical protein	0.079	0.1561	0.1551
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Echinococcus multilocularis	Immunoglobulin	0.008	0.0094	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Brugia malayi	IPT/TIG domain containing protein	0.0147	0.0232	0.0221
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0118	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	regulator of G protein signaling 3	0.079	0.1561	0.1855
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	plexin A	0.0938	0.1865	0.1856
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3736	0.7648	0.914
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Brugia malayi	hypothetical protein	0.0336	0.0622	0.0612
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0049	0.0029	0.0022
Onchocerca volvulus		0.0043	0.0017	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Brugia malayi	MAX-1A	0.0073	0.0077	0.0066
Entamoeba histolytica	PH domain containing protein	0.0073	0.0077	0.0314
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0017	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0104	0.0104
Schistosoma mansoni	tyrosine protein kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0073	0.0077	0.0462
Trypanosoma cruzi	NIMA-related kinase, putative	0.0092	0.0118	1
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0073	0.0077	0.006
Echinococcus multilocularis	regulator of G protein signaling	0.079	0.1561	0.1855
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	integrin linked protein kinase	0.0049	0.0029	0.0022
Entamoeba histolytica	hypothetical protein	0.0147	0.0232	0.1322
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Brugia malayi	serine/threonine protein kinase 6	0.008	0.0092	0.0081
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0049	0.0029	0.0018
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0049	0.0029	0.0022
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0073	0.0077	0.0079
Entamoeba histolytica	hypothetical protein	0.079	0.1561	1
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Onchocerca volvulus	Tyrosine kinase homolog	0.0049	0.0029	0.0181
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Loa Loa (eye worm)	hypothetical protein	0.079	0.1561	0.1561
Echinococcus granulosus	GRB2 associated binding protein 3	0.0073	0.0077	0.0079
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.4874	1	1
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Loa Loa (eye worm)	Plekhf2 protein	0.0073	0.0077	0.0077
Toxoplasma gondii	hypothetical protein	0.0073	0.0077	0.5981
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0073	0.0077	0.0314
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0049	0.0029	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0049	0.0029	0.0022
Loa Loa (eye worm)	RGS-3 protein	0.079	0.1561	0.1561
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0042	0.0024
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0049	0.0029	0.0022
Loa Loa (eye worm)	hypothetical protein	0.008	0.0094	0.0094
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0017	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.3736	0.7648	0.7644
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0092	0.0118	0.0721
Brugia malayi	probable spectrin beta chain	0.0073	0.0077	0.0066
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus multilocularis	aurora kinase A	0.008	0.0092	0.0097
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Entamoeba histolytica	protein kinase , putative	0.008	0.0092	0.041
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0049	0.0029	0.0022
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	protein kinase, putative	0.0092	0.0118	0.0577
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0147	0.0232	0.1455
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0049	0.0029	0.0022
Schistosoma mansoni	hypothetical protein	0.0073	0.0077	0.006
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.0029	0.0022
Schistosoma mansoni	protein kinase	0.0049	0.0029	0.0012
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0073	0.0077	0.0079
Echinococcus multilocularis	Pleckstrin y	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0029	0.0154
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0049	0.0029	0.0181
Trichomonas vaginalis	protein transport protein sec7, putative	0.0073	0.0077	0.0462
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0049	0.0029	0.0022
Echinococcus granulosus	aurora kinase A	0.008	0.0092	0.0097
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.008	0.0092	0.041
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Toxoplasma gondii	STE kinase	0.0049	0.0029	0.1194
Trichomonas vaginalis	centaurin/arf, putative	0.0073	0.0077	0.0462
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Brugia malayi	SH2 domain containing protein	0.0049	0.0029	0.0018
Loa Loa (eye worm)	TK/CSK protein kinase	0.0049	0.0029	0.0029
Toxoplasma gondii	protein kinase domain-containing protein	0.0092	0.0118	1
Brugia malayi	SRC-1	0.0049	0.0029	0.0018
Schistosoma mansoni	protein tyrosine kinase	0.0049	0.0029	0.0012
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0049	0.0029	0.0022
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0011	0.0011
Echinococcus granulosus	activated cdc42 kinase 1	0.0049	0.0029	0.0022
Echinococcus granulosus	oxysterol binding protein 9	0.0073	0.0077	0.0079
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Echinococcus multilocularis	activin receptor type	0.0069	0.007	0.007
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0092	0.0118	0.0577
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Echinococcus multilocularis	epidermal growth factor receptor	0.0049	0.0029	0.0022
Schistosoma mansoni	myotubularin-related protein	0.0073	0.0077	0.006
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0049	0.0029	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0042	0.0024
Brugia malayi	SH2 domain containing protein	0.0049	0.0029	0.0018
Trypanosoma brucei	protein kinase, putative	0.0069	0.007	0.5213
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.0029	0.0154
Leishmania major	protein kinase, putative	0.0049	0.0029	0.1194
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Echinococcus granulosus	epidermal growth factor receptor	0.0049	0.0029	0.0022
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.0029	0.0022
Toxoplasma gondii	AtPH1 family protein	0.0073	0.0077	0.5981
Loa Loa (eye worm)	TK protein kinase	0.0049	0.0029	0.0029
Echinococcus granulosus	tyrosine protein kinase Blk	0.0049	0.0029	0.0022
Loa Loa (eye worm)	oxysterol binding protein	0.0073	0.0077	0.0077
Trichomonas vaginalis	conserved hypothetical protein	0.079	0.1561	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0049	0.0029	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0073	0.0077	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Trichomonas vaginalis	kinesin light chain, putative	0.0073	0.0077	0.0462
Schistosoma mansoni	dynamin	0.0073	0.0077	0.006
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0092	0.0118	1
Echinococcus multilocularis	FL cytokine receptor	0.0049	0.0029	0.0022
Schistosoma mansoni	zinc finger protein	0.0073	0.0077	0.006
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0073	0.0077	0.0079
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0049	0.0029	0.0029
Brugia malayi	PXA domain containing protein	0.079	0.1561	0.1551
Plasmodium vivax	protein kinase, putative	0.0049	0.0029	0.1194
Echinococcus granulosus	regulator of G protein signaling 7	0.079	0.1561	0.1855
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0073	0.0077	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0622	0.0622
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Schistosoma mansoni	hypothetical protein	0.0336	0.0622	0.0606
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0049	0.0029	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0232	0.0232
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0029	0.0029
Onchocerca volvulus		0.0073	0.0077	0.0488
Plasmodium falciparum	protein kinase, putative	0.0069	0.007	0.4564
Onchocerca volvulus		0.0049	0.0029	0.0181
Schistosoma mansoni	vav2	0.0073	0.0077	0.006
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2946	0.6015	0.7186
Echinococcus multilocularis	roundabout 2	0.0085	0.0104	0.0111
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0092	0.0118	1
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0073	0.0077	0.0079
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0092	0.0118	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Echinococcus granulosus	c src tyrosine kinase	0.0049	0.0029	0.0022
Onchocerca volvulus		0.0049	0.0029	0.0181
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0049	0.0029	0.1194
Mycobacterium ulcerans	lipase LipD	0.0043	0.0017	0.5
Loa Loa (eye worm)	syntrophin-1	0.0073	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Echinococcus granulosus	cytohesin 1	0.0073	0.0077	0.0079
Schistosoma mansoni	oxysterol-binding protein 1	0.0073	0.0077	0.006
Schistosoma mansoni	regulator of G protein signaling	0.079	0.1561	0.1546
Brugia malayi	hypothetical protein	0.0049	0.0029	0.0018
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.4874	1	1
Schistosoma mansoni	regulator of G protein signaling	0.079	0.1561	0.1546
Trichomonas vaginalis	centaurin/arf, putative	0.0073	0.0077	0.0462
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0029	0.0022
Echinococcus granulosus	neuroglian	0.008	0.0094	0.0099
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0049	0.0029	0.0029
Loa Loa (eye worm)	AUR protein kinase	0.008	0.0092	0.0092
Echinococcus multilocularis	transfer RNA-Thr	0.0049	0.0029	0.0022
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0073	0.0077	0.0079
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0049	0.0029	0.0029
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0073	0.0077	0.0314
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0073	0.0077	0.0488
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0073	0.0077	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0232	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0029	0.0029
Schistosoma mansoni	voltage-gated potassium channel	0.0044	0.0019	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0017	0.0017
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Onchocerca volvulus		0.0336	0.0622	0.3978
Loa Loa (eye worm)	TK/ABL protein kinase	0.0049	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0029	0.0018
Echinococcus granulosus	plexin a4	0.0938	0.1865	0.2219
Schistosoma mansoni	hypothetical protein	0.0073	0.0077	0.006
Brugia malayi	PH domain containing protein	0.0073	0.0077	0.0066
Schistosoma mansoni	hypothetical protein	0.0049	0.0029	0.0012
Brugia malayi	Regulator of G protein signaling domain containing protein	0.079	0.1561	0.1551
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.0092	0.0075
Schistosoma mansoni	tyrosine kinase	0.0049	0.0029	0.0012
Entamoeba histolytica	tyrosin kinase, putative	0.0196	0.0334	0.1987
Loa Loa (eye worm)	plexin A	0.0938	0.1865	0.1865
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0049	0.0029	0.0022
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0073	0.0077	0.5981
Brugia malayi	serine/threonine-protein kinase 6	0.008	0.0092	0.0081

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.7783 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1548860

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1415358