Detailed information for compound 1448287

Basic information

Technical information
  • TDR Targets ID: 1448287
  • Name: 4-(2-chlorophenoxy)-N'-hydroxy-3-nitrobenzene carboximidamide
  • MW: 307.689 | Formula: C13H10ClN3O4
  • H donors: 2 H acceptors: 3 LogP: 3.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON=C(c1ccc(c(c1)[N+](=O)[O-])Oc1ccccc1Cl)N
  • InChi: 1S/C13H10ClN3O4/c14-9-3-1-2-4-11(9)21-12-6-5-8(13(15)16-18)7-10(12)17(19)20/h1-7,18H,(H2,15,16)
  • InChiKey: JASJRKPHJVGORG-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-(2-chlorophenoxy)-N'-hydroxy-3-nitro-benzamidine
  • 4-(2-chlorophenoxy)-N'-hydroxy-3-nitrobenzamidine
  • 4-(2-chlorophenoxy)-N'-hydroxy-3-nitro-benzenecarboximidamide
  • MLS000859502
  • SMR000461279
  • Maybridge1_008397

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0579 0.0868
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0124 0.0061 0.0063
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0182 0.0332 0.0422
Echinococcus multilocularis serine:threonine protein kinase 0.0224 0.0532 0.0676
Giardia lamblia Kinase, PLK 0.0555 0.2094 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0861 0.0861
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Echinococcus granulosus mitogen activated protein kinase 0.016 0.0229 0.0237
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0145 0.0158 0.0436
Brugia malayi Variant SH3 domain containing protein 0.0158 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.013 0.0086 0.0089
Onchocerca volvulus 0.0118 0.0029 0.0032
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0394 0.1333 0.1694
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0303 0.0905 0.0905
Schistosoma mansoni nephrin 0.013 0.0086 0.0129
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0145 0.0158 0.0158
Entamoeba histolytica protein kinase, putative 0.0133 0.01 0.0316
Loa Loa (eye worm) hypothetical protein 0.0233 0.0575 0.0575
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0255 0.0678 0.0678
Brugia malayi Protein kinase domain containing protein 0.0612 0.2363 0.2363
Schistosoma mansoni unc-13 (munc13) 0.013 0.0087 0.0131
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0217 0.0499 0.0499
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0818 0.3332 0.4233
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0283 0.0424
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Brugia malayi Protein kinase domain containing protein 0.0297 0.0874 0.0874
Echinococcus granulosus dual specificity 0.0157 0.0215 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0194 0.0291
Trypanosoma cruzi casein kinase, putative 0.017 0.0276 0.1197
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0171 0.0281 0.0281
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0612 0.2363 0.2363
Onchocerca volvulus 0.0506 0.1862 0.2084
Echinococcus multilocularis unc 13 (munc13) 0.013 0.0087 0.0111
Brugia malayi cell division control protein 2 homolog 0.0234 0.0579 0.0579
Echinococcus multilocularis mitogen activated protein kinase 3 0.016 0.0229 0.029
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0319
Entamoeba histolytica protein kinase, putative 0.0133 0.01 0.0316
Schistosoma mansoni tyrosine kinase 0.0851 0.3488 0.5225
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0245 0.063 0.0801
Echinococcus granulosus Immunoglobulin 0.0224 0.0529 0.0549
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0145 0.0158 0.0158
Entamoeba histolytica p21-activated kinase 0.018 0.0322 0.1398
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0139 0.013 0.013
Leishmania major protein kinase, putative 0.0145 0.0158 0.0269
Echinococcus multilocularis 0.0171 0.0281 0.0357
Onchocerca volvulus 0.0454 0.1615 0.1808
Echinococcus granulosus peroxidasin 0.0112 0.0003 0.0003
Brugia malayi protein kinase C3,putative 0.0355 0.1151 0.1151
Echinococcus multilocularis roundabout 2 0.0353 0.1141 0.1449
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.016 0.0229 0.0624
Giardia lamblia Kinase, CK1 Casein kinase 0.017 0.0276 0.0861
Echinococcus granulosus tyrosine protein kinase Src42A 0.0405 0.1386 0.1439
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0289 0.0839 0.1066
Brugia malayi Tyrosine-protein kinase abl-1 0.0271 0.0755 0.0755
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.026 0.0699 0.0888
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0104 0.0156
Echinococcus granulosus serine:threonine protein kinase 0.0224 0.0532 0.0553
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0235 0.0582 0.0604
Schistosoma mansoni tyrosine kinase 0.0305 0.0915 0.137
Plasmodium falciparum protein kinase 5 0.0234 0.0579 0.3104
Echinococcus multilocularis Glutaredoxin protein 5 0.0235 0.0582 0.0739
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0368 0.1212 0.1212
Brugia malayi Furin-like cysteine rich region family protein 0.1292 0.5569 0.5569
Echinococcus granulosus casein kinase I gamma 0.023 0.0561 0.0582
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0149 0.0178 0.0184
Echinococcus multilocularis NCK adaptor protein 0.0159 0.0226 0.0288
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0234 0.0579 0.2387
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0162 0.0238 0.1013
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0678 0.3224
Loa Loa (eye worm) protein kinase domain-containing protein 0.023 0.0561 0.0561
Echinococcus multilocularis casein kinase i 0.017 0.0276 0.035
Loa Loa (eye worm) hypothetical protein 0.0177 0.0308 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0458 0.1634 0.2448
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0329 0.1026 0.1026
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0158 0.0217 0.0217
Trypanosoma brucei cdc2-related kinase 1 0.0234 0.0579 0.2387
Echinococcus multilocularis raf serine:threonine protein kinase 0.1526 0.6675 0.8478
Brugia malayi Temporarily assigned gene name protein 59 0.0273 0.0763 0.0763
Loa Loa (eye worm) AGC/NDR protein kinase 0.0297 0.0874 0.0874
Echinococcus multilocularis N chimaerin 0.0217 0.0499 0.0634
Echinococcus multilocularis protein kinase shaggy 0.0255 0.0678 0.0861
Entamoeba histolytica protein kinase, putative 0.0255 0.0678 0.3124
Echinococcus granulosus mitogen activated protein kinase 14 0.032 0.0982 0.102
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Entamoeba histolytica protein kinase 2, putative 0.0287 0.0829 0.386
Loa Loa (eye worm) hypothetical protein 0.0182 0.0332 0.0332
Brugia malayi Hr1 repeat family protein 0.0425 0.1478 0.1478
Echinococcus granulosus tyrosine protein kinase Src64B 0.0405 0.1386 0.1439
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0182 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.016 0.0229 0.0342
Echinococcus multilocularis cyclin dependent kinase 1 0.0234 0.0579 0.0736
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0182 0.0332 0.0345
Echinococcus granulosus serine/threonine protein kinase 0.0302 0.09 0.0935
Schistosoma mansoni tyrosine kinase 0.0405 0.1386 0.2077
Schistosoma mansoni hypothetical protein 0.0205 0.0439 0.0658
Echinococcus multilocularis dual specificity 0.0242 0.0614 0.0779
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Onchocerca volvulus 0.017 0.0276 0.0309
Trypanosoma brucei protein kinase, putative 0.016 0.0229 0.0624
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Loa Loa (eye worm) hypothetical protein 0.0142 0.0146 0.0146
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0145 0.0158 0.0436
Schistosoma mansoni serine/threonine protein kinase 0.0491 0.179 0.2681
Brugia malayi Raf kinase 0.1399 0.6074 0.6074
Echinococcus multilocularis myotubularin protein 13 0.0142 0.0146 0.0185
Loa Loa (eye worm) hypothetical protein 0.0591 0.2262 0.2262
Entamoeba histolytica PH domain containing protein kinase, putative 0.0192 0.0379 0.1672
Loa Loa (eye worm) hypothetical protein 0.013 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0263 0.0713 0.0713
Echinococcus granulosus NDR protein kinase 0.0297 0.0874 0.0907
Entamoeba histolytica protein kinase, putative 0.0248 0.0643 0.2955
Trypanosoma cruzi casein kinase, putative 0.017 0.0276 0.1197
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0234 0.0579 0.0579
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0612 0.2363 0.2363
Loa Loa (eye worm) hypothetical protein 0.0361 0.1176 0.1176
Trichomonas vaginalis STE family protein kinase 0.0119 0.0035 0.0145
Brugia malayi RhoGEF domain containing protein 0.0127 0.0075 0.0075
Brugia malayi Sex muscle abnormal protein 5 0.0158 0.0217 0.0217
Schistosoma mansoni protein kinase 0.017 0.0276 0.0413
Loa Loa (eye worm) hypothetical protein 0.0242 0.0615 0.0615
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0145 0.0158 0.0871
Echinococcus granulosus rho-associated protein kinase 1 0.0506 0.1862 0.1933
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0172 0.0283 0.1233
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.016 0.0229 0.0806
Plasmodium vivax protein kinase Crk2 0.0234 0.0579 0.3476
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0255 0.0678 0.2883
Schistosoma mansoni cell adhesion molecule 0.0299 0.0884 0.1324
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0172 0.0283 0.1092
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.032 0.0982 0.4413
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.017 0.0276 0.0276
Entamoeba histolytica serine/threonine protein kinase, putative 0.0555 0.2094 1
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0104 0.0476
Loa Loa (eye worm) TK protein kinase 0.0331 0.1037 0.1037
Echinococcus multilocularis mitogen activated protein kinase 14 0.032 0.0982 0.1248
Giardia lamblia Kinase, NEK 0.0271 0.0753 0.3258
Schistosoma mansoni nck2/grb4 0.0158 0.0217 0.0325
Loa Loa (eye worm) hypothetical protein 0.0335 0.1055 0.1055
Brugia malayi Protein kinase domain containing protein 0.0234 0.0579 0.0579
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0405 0.1386 0.1439
Brugia malayi SH2 domain containing protein 0.0185 0.0344 0.0344
Trypanosoma cruzi polo-like protein kinase, putative 0.0555 0.2094 1
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Echinococcus multilocularis casein kinase I gamma 0.023 0.0561 0.0712
Schistosoma mansoni serine/threonine protein kinase 0.038 0.1267 0.1899
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0532 0.1982 0.1982
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.017 0.0276 0.0276
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0555 0.2094 0.2173
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0172 0.0283 0.1233
Entamoeba histolytica protein kinase, putative 0.0142 0.0145 0.0539
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0133 0.0104 0.0132
Echinococcus granulosus roundabout 2 0.013 0.0086 0.0089
Schistosoma mansoni tyrosine kinase 0.0851 0.3488 0.5225
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0666 0.2618 0.2718
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Brugia malayi Variant SH3 domain containing protein 0.0158 0.0217 0.0217
Echinococcus multilocularis roundabout 2 0.013 0.0086 0.0109
Schistosoma mansoni ste20-related kinase 0.0417 0.1442 0.2161
Schistosoma mansoni tyrosine kinase 0.0947 0.3944 0.5908
Schistosoma mansoni protein kinase 0.0474 0.171 0.2562
Loa Loa (eye worm) TK/EPH protein kinase 0.0267 0.0736 0.0736
Schistosoma mansoni cell adhesion molecule 0.013 0.0086 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0158 0.0237
Toxoplasma gondii histone kinase SNF1, putative 0.0134 0.0104 0.0155
Echinococcus multilocularis serine:threonine protein kinase 0.0224 0.0532 0.0676
Loa Loa (eye worm) TK/FER protein kinase 0.0484 0.1758 0.1758
Schistosoma mansoni tyrosine kinase 0.0252 0.0663 0.0994
Trichomonas vaginalis CMGC family protein kinase 0.0234 0.0579 0.2752
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0475 0.1715 0.1715
Onchocerca volvulus 0.0185 0.0344 0.0386
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0286 0.0822 0.0822
Echinococcus granulosus casein kinase I delta 0.017 0.0276 0.0286
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0405 0.1386 0.1761
Echinococcus multilocularis epidermal growth factor receptor 0.1292 0.5569 0.7073
Echinococcus multilocularis ephrin type A receptor 4 A 0.023 0.056 0.0711
Loa Loa (eye worm) hypothetical protein 0.0119 0.0036 0.0036
Trypanosoma brucei aurora B kinase 0.0458 0.1634 0.7689
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0162 0.0238 0.1013
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0153 0.0194 0.0247
Echinococcus granulosus serine:threonine protein kinase N2 0.0128 0.0078 0.0081
Echinococcus granulosus defective proboscis extension response 0.0224 0.0529 0.0549
Schistosoma mansoni serine/threonine-protein kinase 0.0302 0.09 0.1349
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0391
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0458 0.1634 0.1696
Brugia malayi p70 ribosomal S6 kinase beta 0.0532 0.1982 0.1982
Trichomonas vaginalis CK1 family protein kinase 0.017 0.0276 0.13
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0405 0.1386 0.1761
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0458 0.1634 0.7767
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0673 0.2648 0.2648
Schistosoma mansoni protein kinase 0.021 0.0466 0.0698
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0217 0.0499 0.0634
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0104 0.0476
Loa Loa (eye worm) hypothetical protein 0.0224 0.0529 0.0529
Giardia lamblia Kinase, STE STE20 0.0165 0.0251 0.0739
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.1862 0.279
Echinococcus granulosus hypothetical protein 0.0119 0.0036 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0405 0.1386 0.1761
Entamoeba histolytica protein kinase, putative 0.0532 0.1982 0.9461
Entamoeba histolytica protein kinase, putative 0.0547 0.2053 0.9805
Schistosoma mansoni tyrosine kinase 0.0756 0.3041 0.4557
Echinococcus granulosus NCK adaptor protein 0.0158 0.0217 0.0225
Brugia malayi Protein kinase domain containing protein 0.026 0.0699 0.0699
Echinococcus granulosus mitogen activated protein kinase 3 0.016 0.0229 0.0237
Schistosoma mansoni protein kinase 0.0269 0.0742 0.1111
Schistosoma mansoni nephrin 0.0296 0.0872 0.1307
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0104 0.0156
Trypanosoma brucei cdc2-related kinase 3 0.0234 0.0579 0.2387
Trichomonas vaginalis AGC family protein kinase 0.0458 0.1634 0.78
Toxoplasma gondii casein kinase I 0.017 0.0276 0.1053
Schistosoma mansoni serine/threonine protein kinase 0.038 0.1267 0.1899
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0242 0.0614 0.2833
Entamoeba histolytica protein kinase, putative 0.0145 0.0158 0.06
Loa Loa (eye worm) AGC/AKT protein kinase 0.0547 0.2053 0.2053
Onchocerca volvulus Serine\/threonine kinase homolog 0.0555 0.2094 0.2343
Trypanosoma brucei casein kinase I, isoform 2 0.017 0.0276 0.0861
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0145 0.0158 0.0164
Echinococcus granulosus epidermal growth factor receptor 0.1292 0.5569 0.5781
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0394 0.1333 0.1384
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Brugia malayi C1-like domain containing protein 0.0413 0.1423 0.1423
Entamoeba histolytica protein kinase, putative 0.0157 0.0215 0.0876
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0297 0.0874 0.111
Schistosoma mansoni neuroglian 0.013 0.0086 0.0129
Entamoeba histolytica casein kinase, putative 0.0195 0.0392 0.1738
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Schistosoma mansoni protein kinase C 0.013 0.0087 0.0131
Echinococcus granulosus dual specificity 0.0157 0.0215 0.0223
Onchocerca volvulus 0.1855 0.823 0.9212
Giardia lamblia Kinase, CMGC CK2 0.0195 0.0392 0.1447
Trichomonas vaginalis AGC family protein kinase 0.0271 0.0753 0.3582
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Echinococcus multilocularis dual specificity 0.0157 0.0215 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.0167 0.0672
Echinococcus granulosus protein kinase c iota type 0.06 0.2304 0.2392
Giardia lamblia Aurora kinase 0.0458 0.1634 0.7689
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0329 0.1026 0.1026
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0133 0.01 0.0104
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.0167 0.0672
Echinococcus multilocularis mitogen activated protein kinase 11 0.032 0.0982 0.1248
Echinococcus granulosus growth factor receptor bound protein 2 0.0159 0.0226 0.0235
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.026 0.0699 0.0699
Plasmodium falciparum calcium-dependent protein kinase 2 0.0145 0.0158 0.035
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.015 0.0182 0.0231
Leishmania major casein kinase, putative 0.017 0.0276 0.0861
Brugia malayi serine/threonine-protein kinase 6 0.0458 0.1634 0.1634
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0408 0.1398 0.1776
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0515 0.1902 0.2416
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.01 0.0149
Echinococcus granulosus tyrosine protein kinase Blk 0.0338 0.1067 0.1108
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0234 0.0579 0.0601
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.1333 0.1998
Echinococcus granulosus protein kinase 0.0171 0.0281 0.0292
Echinococcus multilocularis serine threonine protein kinase 0.0383 0.1283 0.163
Onchocerca volvulus 0.0233 0.0575 0.0644
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0308 0.0461
Trypanosoma cruzi polo-like protein kinase, putative 0.0555 0.2094 1
Trypanosoma brucei protein kinase, putative 0.0255 0.0678 0.2883
Trypanosoma cruzi Protein kinase B 0.0302 0.09 0.4222
Echinococcus multilocularis Immunoglobulin 0.0224 0.0529 0.0672
Schistosoma mansoni tyrosine kinase 0.0161 0.0234 0.035
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0217 0.0499 0.0748
Echinococcus granulosus protein tyrosine kinase 0.0594 0.2278 0.2365
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0405 0.1386 0.1761
Echinococcus granulosus c src tyrosine kinase 0.0252 0.0663 0.0689
Entamoeba histolytica diacylglycerol kinase, putative 0.0127 0.0075 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Onchocerca volvulus 0.013 0.0087 0.0098
Brugia malayi Serine/threonine-protein kinase SULU 0.0239 0.0603 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0542 0.2033 0.3046
Echinococcus granulosus tyrosine protein kinase shark 0.0395 0.1339 0.139
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0157 0.0215 0.0555
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0177 0.0308 0.1797
Echinococcus granulosus casein kinase I alpha 0.017 0.0276 0.0286
Schistosoma mansoni tyrosine kinase 0.0534 0.1994 0.2987
Echinococcus granulosus casein kinase I alpha 0.017 0.0276 0.0286
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0134 0.0104 0.0368
Giardia lamblia Kinase, NEK 0.0271 0.0753 0.3258
Loa Loa (eye worm) raf kinase 0.1431 0.6229 0.6229
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0172 0.0283 0.1233
Echinococcus multilocularis epidermal growth factor receptor 0.0851 0.3488 0.443
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.0229 0.0969
Echinococcus multilocularis Immunoglobulin 0.0224 0.0529 0.0672
Echinococcus multilocularis cyclin dependent kinase 0.0234 0.0579 0.0736
Loa Loa (eye worm) hypothetical protein 0.0441 0.1555 0.1555
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0224 0.0529 0.0672
Echinococcus granulosus mitogen activated protein kinase 11 0.032 0.0982 0.102
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0297 0.0874 0.111
Schistosoma mansoni tyrosine kinase 0.0206 0.0446 0.0669
Entamoeba histolytica diacylglycerol kinase, putative 0.0127 0.0075 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0158 0.0736
Loa Loa (eye worm) hypothetical protein 0.0216 0.0495 0.0495
Schistosoma mansoni protein kinase 0.026 0.0699 0.1047
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0224 0.0529 0.0793
Echinococcus multilocularis cyclin dependent kinase 1 0.0234 0.0579 0.0736
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0235 0.0582 0.0739
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.0167 0.0315
Echinococcus multilocularis protein kinase c epsilon type 0.0427 0.1488 0.189
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0255 0.0678 0.3144
Onchocerca volvulus 0.0185 0.0344 0.0386
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0549 0.2063 0.2621
Plasmodium falciparum protein kinase, putative 0.0147 0.0167 0.041
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0287 0.0829 0.1053
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0172 0.0283 0.0899
Giardia lamblia Kinase, CMGC DYRK 0.0157 0.0215 0.0555
Brugia malayi Protein kinase domain containing protein 0.0432 0.1511 0.1511
Echinococcus multilocularis nervana 2 0.0235 0.0582 0.0739
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0319
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0458 0.1634 0.7767
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0172 0.0283 0.0283
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0165 0.0251 0.0319
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0134 0.0104 0.054
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0405 0.1386 0.1761
Schistosoma mansoni protein kinase 0.0165 0.0251 0.0377
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0281 0.0798 0.0828
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Loa Loa (eye worm) hypothetical protein 0.0294 0.0861 0.0861
Brugia malayi Homeodomain interacting protein kinase protein 1 0.022 0.0511 0.0511
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0271 0.0753 0.3553
Brugia malayi Fes/CIP4 homology domain containing protein 0.0142 0.0146 0.0146
Brugia malayi Cam kinase protein 1 0.0145 0.0158 0.0158
Schistosoma mansoni serine/threonine-protein kinase 0.0302 0.09 0.1349
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0195 0.0392 0.2321
Loa Loa (eye worm) TK/ALK protein kinase 0.0596 0.2284 0.2284
Schistosoma mansoni rac gtpase activating protein 0.0127 0.0075 0.0112
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0555 0.2094 0.2659
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.016 0.0229 0.0229
Schistosoma mansoni atypical protein kinase C 0.0613 0.2365 0.3543
Echinococcus granulosus tyrosine protein kinase ABL1 0.0624 0.2418 0.251
Echinococcus multilocularis aurora kinase A 0.0458 0.1634 0.2075
Brugia malayi diacylglycerol kinase 0.0127 0.0075 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Echinococcus granulosus tyrosine protein kinase Fyn 0.0405 0.1386 0.1439
Entamoeba histolytica casein kinase 1, putative 0.017 0.0276 0.1171
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0149 0.0178 0.0226
Brugia malayi hypothetical protein 0.0242 0.0615 0.0615
Plasmodium falciparum glycogen synthase kinase 3 0.0255 0.0678 0.3749
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0239 0.0603 0.0766
Echinococcus granulosus epidermal growth factor receptor 0.0851 0.3488 0.3621
Trichomonas vaginalis STE family protein kinase 0.0165 0.0251 0.1183
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.0238 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Echinococcus granulosus Diacylglycerol kinase theta 0.0127 0.0075 0.0078
Echinococcus granulosus protein kinase C gamma type 0.0383 0.1283 0.1332
Brugia malayi hypothetical protein 0.0185 0.0344 0.0344
Brugia malayi Protein kinase domain containing protein 0.0185 0.0344 0.0344
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.032 0.0982 0.4619
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0405 0.1386 0.1761
Loa Loa (eye worm) hypothetical protein 0.0335 0.1055 0.1055
Entamoeba histolytica cell division protein kinase 2, putative 0.0234 0.0579 0.2645
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Echinococcus multilocularis nervana 2 0.0235 0.0582 0.0739
Onchocerca volvulus 0.0185 0.0344 0.0386
Echinococcus multilocularis activin receptor type 0.0147 0.0167 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0297 0.0874 0.4164
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Entamoeba histolytica protein kinase, putative 0.0155 0.0206 0.0833
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0405 0.1386 0.1761
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0194 0.0291
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0134 0.0104 0.0368
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0271 0.0753 0.4549
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0177 0.0308 0.1352
Trichomonas vaginalis CAMK family protein kinase 0.025 0.0655 0.3115
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0177 0.0308 0.1329
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Brugia malayi serine/threonine-protein kinase plk-2 0.0555 0.2094 0.2094
Giardia lamblia Kinase, CMGC CDK 0.0234 0.0579 0.2387
Schistosoma mansoni growth factor receptor-bound protein 0.0158 0.0217 0.0325
Loa Loa (eye worm) hypothetical protein 0.0185 0.0344 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Brugia malayi serine/threonine protein kinase 6 0.0458 0.1634 0.1634
Brugia malayi Doublecortin family protein 0.0169 0.027 0.027
Plasmodium falciparum casein kinase 2, alpha subunit 0.0195 0.0392 0.1882
Loa Loa (eye worm) hypothetical protein 0.017 0.0275 0.0275
Giardia lamblia Kinase, CMGC MAPK 0.016 0.0229 0.0624
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0239 0.0603 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0511 0.1884 0.2823
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0145 0.0158 0.0201
Trypanosoma cruzi casein kinase, delta isoform, putative 0.017 0.0276 0.1197
Echinococcus granulosus raf serine:threonine protein kinase 0.1526 0.6675 0.693
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.013 0.0086 0.0109
Echinococcus granulosus tyrosine protein kinase HCK 0.0248 0.0643 0.0667
Onchocerca volvulus 0.0376 0.1247 0.1396
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Onchocerca volvulus 0.0255 0.0678 0.0759
Plasmodium falciparum calcium-dependent protein kinase 5 0.0145 0.0158 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0234 0.0579 0.2752
Loa Loa (eye worm) AGC/PKN protein kinase 0.0425 0.1478 0.1478
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0177 0.0308 0.1352
Brugia malayi serine/threonine-protein kinase PAK 7 0.0474 0.1712 0.1712
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0255 0.0678 0.0704
Entamoeba histolytica serine/threonine protein kinase, putative 0.0134 0.0104 0.034
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.0064 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Echinococcus granulosus Glutaredoxin protein 5 0.0235 0.0582 0.0604
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Brugia malayi Protein kinase domain containing protein 0.0317 0.0969 0.0969
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0408 0.1398 0.1452
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0394 0.1333 0.1384
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0491 0.2332
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0474 0.1712 0.1712
Loa Loa (eye worm) CAMK protein kinase 0.0125 0.0064 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0874 0.131
Giardia lamblia Kinase, CMGC CDK 0.0234 0.0579 0.2387
Trichomonas vaginalis STE family protein kinase 0.0165 0.0251 0.1183
Schistosoma mansoni diacylglycerol kinase theta 0.0127 0.0075 0.0112
Entamoeba histolytica protein kinase, putative 0.0458 0.1634 0.7767
Schistosoma mansoni protein kinase C mu 0.0127 0.0075 0.0112
Echinococcus granulosus N chimaerin 0.0217 0.0499 0.0518
Echinococcus multilocularis death associated protein kinase 1 0.178 0.7873 1
Echinococcus granulosus myotubularin protein 13 0.0142 0.0146 0.0151
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0127 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0614 0.0919
Echinococcus multilocularis contactin neuroglian septate junction protein 0.013 0.0086 0.0109
Echinococcus multilocularis tyrosine protein kinase 0.0331 0.1037 0.1317
Echinococcus granulosus titin 0.0125 0.0064 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0104 0.0156
Schistosoma mansoni tyrosine kinase 0.0594 0.2278 0.3413
Echinococcus granulosus homeodomain interacting protein kinase 3 0.022 0.0511 0.0531
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0508 0.1871 0.2376
Echinococcus granulosus unc 13 munc13 0.013 0.0087 0.0091
Entamoeba histolytica protein kinase domain containing protein 0.0157 0.0215 0.0876
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Plasmodium falciparum NIMA related kinase 1 0.0271 0.0753 0.4238
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.016 0.0229 0.0969
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0234 0.0579 0.2387
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0234 0.0579 0.0579
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0177 0.0308 0.1221
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0155 0.0206 0.0206
Leishmania major protein kinase, putative 0.0172 0.0283 0.0899
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0145 0.0158 0.0164
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Onchocerca volvulus 0.0185 0.0344 0.0386
Onchocerca volvulus 0.0136 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0252 0.0663 0.0663
Echinococcus granulosus serine:threonine protein kinase 0.0224 0.0532 0.0553
Echinococcus granulosus insulin receptor 0.0947 0.3944 0.4094
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0476 0.1722 0.1787
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0527 0.1959 0.1959
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0157 0.0215 0.0215
Entamoeba histolytica hypothetical protein 0.0375 0.1245 0.5877
Brugia malayi SRC-1 0.0405 0.1386 0.1386
Echinococcus multilocularis serine:threonine protein kinase N2 0.0128 0.0078 0.0099
Brugia malayi Egg laying defective protein 4 0.0153 0.0194 0.0194
Echinococcus granulosus cGMP dependent protein kinase 1 0.0153 0.0194 0.0202
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0946 0.0946
Entamoeba histolytica hypothetical protein 0.0242 0.0614 0.2812
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.015 0.0182 0.0189
Loa Loa (eye worm) hypothetical protein 0.0224 0.0532 0.0532
Echinococcus granulosus roundabout 2 0.0353 0.1141 0.1185
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0145 0.0158 0.0164
Entamoeba histolytica protein kinase, putative 0.0297 0.0874 0.4078
Trichomonas vaginalis AGC family protein kinase 0.0458 0.1634 0.78
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0153 0.0194 0.0627
Trichomonas vaginalis AGC family protein kinase 0.0458 0.1634 0.78
Schistosoma mansoni tyrosine kinase 0.0947 0.3944 0.5908
Echinococcus multilocularis geminin 0.0205 0.0439 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Brugia malayi Protein kinase domain containing protein 0.021 0.0466 0.0466
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0133 0.0104 0.0108
Toxoplasma gondii AGC kinase 0.0532 0.1982 1
Brugia malayi protein unc-22 0.0125 0.0064 0.0064
Giardia lamblia Kinase, AGC PKA 0.0177 0.0308 0.1022
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.016 0.0229 0.0624
Leishmania major protein kinase, putative 0.0458 0.1634 0.7689
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.016 0.0229 0.0969
Echinococcus multilocularis tyrosine protein kinase shark 0.0395 0.1339 0.1701
Echinococcus granulosus cGMP dependent protein kinase 1 0.0153 0.0194 0.0202
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.0086 0.0086
Echinococcus multilocularis 0.0368 0.121 0.1537
Onchocerca volvulus 0.0124 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.0189 0.0366 0.0366
Echinococcus multilocularis tyrosine protein kinase Blk 0.0338 0.1067 0.1356
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.022 0.0511 0.0511
Plasmodium vivax calcium-dependent protein kinase, putative 0.0145 0.0158 0.0871
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0252 0.0663 0.0994
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0134 0.0104 0.0104
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0391
Trichomonas vaginalis STE family protein kinase 0.0271 0.0753 0.3582
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0162 0.0238 0.067
Trichomonas vaginalis AGC family protein kinase 0.0317 0.0969 0.462
Echinococcus granulosus serine:threonine protein kinase 3 0.0527 0.1959 0.2034
Schistosoma mansoni diacylglycerol kinase theta 0.0127 0.0075 0.0112
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0177 0.0308 0.1352
Trichomonas vaginalis AGC family protein kinase 0.0317 0.0969 0.462
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0413 0.1423 0.1423
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2231 1 1
Giardia lamblia Kinase, CMGC CLK 0.0172 0.0283 0.0899
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.1333 0.1998
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0522 0.0782
Entamoeba histolytica protein kinase, putative 0.0242 0.0614 0.2812
Echinococcus granulosus dual specificity protein kinase clk2 0.0172 0.0283 0.0294
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0133 0.01 0.0126
Schistosoma mansoni tyrosine kinase 0.0756 0.3041 0.4557
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0391
Echinococcus multilocularis roundabout 2 0.013 0.0086 0.0109
Loa Loa (eye worm) TK/EGFR protein kinase 0.1292 0.5569 0.5569
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.022 0.0511 0.065
Echinococcus granulosus neuroglian 0.0278 0.0787 0.0817
Brugia malayi Immunoglobulin I-set domain containing protein 0.0242 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0233 0.0575 0.0575
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0155 0.0206 0.0206
Brugia malayi Protein kinase domain containing protein 0.0185 0.0344 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Entamoeba histolytica protein kinase, putative 0.0134 0.0106 0.0345
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0287 0.0829 0.0861
Echinococcus multilocularis Diacylglycerol kinase theta 0.0127 0.0075 0.0095
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0234 0.0579 0.2644
Entamoeba histolytica protein kinase, putative 0.0458 0.1634 0.7767
Brugia malayi Protein kinase domain containing protein 0.0172 0.0283 0.0283
Schistosoma mansoni protein kinase 0.0119 0.0035 0.0052
Brugia malayi Fibronectin type III domain containing protein 0.0242 0.0615 0.0615
Echinococcus granulosus tyrosine protein kinase Fyn 0.0405 0.1386 0.1439
Echinococcus multilocularis expressed conserved protein 0.0153 0.0194 0.0247
Brugia malayi Protein kinase domain containing protein 0.0185 0.0344 0.0344
Echinococcus granulosus geminin 0.0205 0.0439 0.0456
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0965 0.4029 0.5118
Brugia malayi probable protein kinase 0.0269 0.0742 0.0742
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0165 0.0251 0.0319
Toxoplasma gondii aurora kinase 0.0458 0.1634 0.8173
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0231 0.0562 0.0562
Schistosoma mansoni serine/threonine kinase 0.0303 0.0905 0.1355
Trichomonas vaginalis CK1 family protein kinase 0.017 0.0276 0.13
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.0086 0.0086
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0549 0.2063 0.2142
Loa Loa (eye worm) hypothetical protein 0.0304 0.0909 0.0909
Entamoeba histolytica protein kinase , putative 0.0458 0.1634 0.7767
Brugia malayi SH2 domain containing protein 0.0484 0.1758 0.1758
Trichomonas vaginalis CAMK family protein kinase 0.0224 0.0532 0.2528
Schistosoma mansoni tyrosine kinase 0.1292 0.5569 0.8343
Schistosoma mansoni hypothetical protein 0.0127 0.0075 0.0112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0145 0.0158 0.0201
Giardia lamblia Kinase, CMGC GSK 0.0255 0.0678 0.2883
Trichomonas vaginalis STE family protein kinase 0.0162 0.0238 0.1118
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0142 0.0145 0.0539
Giardia lamblia Kinase, AGC PKA 0.0287 0.0829 0.3644
Echinococcus multilocularis tyrosine protein kinase Abl 0.042 0.1456 0.185
Leishmania major protein kinase A catalytic subunit isoform 1 0.0177 0.0308 0.1022
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0965 0.4029 0.4183
Echinococcus granulosus tyrosine protein kinase Fyn 0.0405 0.1386 0.1439
Brugia malayi Protein kinase domain containing protein 0.0549 0.2063 0.2063
Echinococcus granulosus dual specificity 0.0242 0.0614 0.0637
Echinococcus multilocularis serine:threonine protein kinase N2 0.0297 0.0874 0.111
Echinococcus granulosus tyrosine protein kinase Src42A 0.0245 0.063 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0206 0.0966
Trypanosoma brucei Casein kinase II 0.0195 0.0392 0.1447
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0302 0.09 0.4222
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0439 0.0492
Brugia malayi diacylglycerol kinase 0.0127 0.0075 0.0075
Brugia malayi Protein kinase domain containing protein 0.1464 0.6382 0.6382
Brugia malayi phosphoinositide-dependent protein kinase I 0.0155 0.0206 0.0206
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Entamoeba histolytica casein kinase, putative 0.017 0.0276 0.1171
Brugia malayi ephrin receptor 1 precursor 0.0158 0.0222 0.0222
Schistosoma mansoni ephrin receptor 0.023 0.056 0.0839
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0289 0.0839 0.0871
Echinococcus multilocularis serine:threonine protein kinase 3 0.0527 0.1959 0.2488
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0515 0.1902 0.2416
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0463 0.1657 0.1657
Echinococcus granulosus casein kinase I delta 0.017 0.0276 0.0286
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0145 0.0158 0.0269
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0458 0.1634 0.7767
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.032 0.0982 0.4413
Loa Loa (eye worm) hypothetical protein 0.0145 0.0158 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.0603 0.0903
Echinococcus multilocularis protein kinase c eta type 0.0127 0.0075 0.0095
Brugia malayi Immunoglobulin I-set domain containing protein 0.0569 0.216 0.216
Loa Loa (eye worm) AUR protein kinase 0.0458 0.1634 0.1634
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Entamoeba histolytica protein kinase, putative 0.0134 0.0106 0.0345
Brugia malayi protein kinase C II. 0.0427 0.1488 0.1488
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Echinococcus multilocularis casein kinase I alpha 0.017 0.0276 0.035
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0427 0.1488 0.1488
Leishmania major casein kinase II, putative 0.0195 0.0392 0.1447
Plasmodium falciparum calcium-dependent protein kinase 3 0.0145 0.0158 0.035
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0145 0.0158 0.0871
Trichomonas vaginalis STE family protein kinase 0.0165 0.0251 0.1183
Trichomonas vaginalis AGC family protein kinase 0.0332 0.104 0.496
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0158 0.0217 0.0325
Plasmodium vivax glycogen synthase kinase 3, putative 0.0255 0.0678 0.4087
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0165 0.0251 0.0319
Trypanosoma cruzi cdc2-related kinase 3 0.0234 0.0579 0.2667
Schistosoma mansoni serine/threonine protein kinase 0.0408 0.1399 0.2095
Brugia malayi Stress-activated protein kinase jnk-1 0.0542 0.2033 0.2033
Echinococcus granulosus activin receptor type 0.0147 0.0167 0.0174
Trypanosoma cruzi casein kinase, putative 0.017 0.0276 0.1197
Loa Loa (eye worm) RasGEF domain-containing protein 0.0127 0.0075 0.0075
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0242 0.0614 0.2833
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0153 0.0194 0.0247
Trypanosoma cruzi cdc2-related kinase 3 0.0234 0.0579 0.2667
Schistosoma mansoni protein kinase 0.0474 0.171 0.2562
Toxoplasma gondii AGC kinase 0.0177 0.0308 0.1221
Echinococcus granulosus tyrosine protein kinase 0.0331 0.1037 0.1077
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0491 0.2332
Loa Loa (eye worm) AGC/PKG protein kinase 0.0153 0.0194 0.0194
Echinococcus granulosus tyrosine kinase 0.0185 0.0344 0.0358
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.0874 0.131
Trichomonas vaginalis CAMK family protein kinase 0.025 0.0655 0.3115
Plasmodium vivax casein kinase 1, putative 0.017 0.0276 0.1599
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0297 0.0874 0.0907
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.013 0.0086 0.0109
Loa Loa (eye worm) hypothetical protein 0.013 0.0086 0.0086
Loa Loa (eye worm) TK protein kinase 0.0394 0.1334 0.1334
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.032 0.0982 0.0982
Trypanosoma cruzi cdc2-related kinase 1 0.0234 0.0579 0.2667
Echinococcus multilocularis mitogen activated protein kinase 11 0.032 0.0982 0.1248
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0158 0.0217 0.0217
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0317 0.0969 0.0969
Brugia malayi Protein kinase domain containing protein 0.0242 0.0614 0.0614
Entamoeba histolytica PH domain containing protein kinase, putative 0.0302 0.09 0.4205
Echinococcus granulosus tyrosine protein kinase Lyn 0.0458 0.1633 0.1696
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0405 0.1386 0.1761
Entamoeba histolytica protein kinase domain containing protein 0.0458 0.1634 0.7767
Schistosoma mansoni ephrin receptor 0.0113 0.0006 0.0009
Echinococcus multilocularis tyrosine kinase 0.0185 0.0344 0.0438
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0475 0.1715 0.2178
Echinococcus multilocularis protein tyrosine kinase 0.0594 0.2278 0.2894
Echinococcus granulosus dual specificity 0.0157 0.0215 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0552 0.0828
Echinococcus granulosus protein kinase shaggy 0.0255 0.0678 0.0704
Trypanosoma cruzi casein kinase II, putative 0.0195 0.0392 0.1762
Loa Loa (eye worm) TK protein kinase 0.0338 0.1067 0.1067
Onchocerca volvulus 0.0185 0.0344 0.0386
Schistosoma mansoni protein kinase 0.0474 0.171 0.2562
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2153 0.9632 1
Echinococcus granulosus twitchin 0.0331 0.1034 0.1073
Toxoplasma gondii AGC kinase 0.0177 0.0308 0.1221
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0242 0.0614 0.2559
Giardia lamblia Kinase, AGC AKT 0.0231 0.0562 0.23
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0206 0.0966
Echinococcus granulosus nervana 2 0.0235 0.0582 0.0604
Echinococcus multilocularis rho associated protein kinase 0.0506 0.1862 0.2365
Onchocerca volvulus 0.0185 0.0344 0.0386
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0242 0.0614 0.2559
Echinococcus multilocularis growth factor receptor bound protein 2 0.0158 0.0217 0.0276
Loa Loa (eye worm) hypothetical protein 0.0281 0.0798 0.0798
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0165 0.0251 0.0261
Entamoeba histolytica protein kinase domain containing protein 0.0255 0.0678 0.3124
Entamoeba histolytica protein kinase, putative 0.0148 0.0171 0.0661
Brugia malayi RhoGAP domain containing protein 0.0127 0.0075 0.0075
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0172 0.0283 0.1233
Echinococcus multilocularis c src tyrosine kinase 0.0252 0.0663 0.0843
Echinococcus granulosus casein kinase ii subunit alpha 0.0195 0.0392 0.0407
Schistosoma mansoni tyrosine kinase 0.0756 0.3041 0.4557
Schistosoma mansoni serine/threonine protein kinase 0.022 0.0511 0.0766
Brugia malayi P38 map kinase family protein 2 0.032 0.0982 0.0982
Brugia malayi Protein kinase c protein 2 0.0266 0.0731 0.0731
Loa Loa (eye worm) TK protein kinase 0.0569 0.216 0.216
Schistosoma mansoni protein kinase 0.0147 0.0167 0.025
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0157 0.0215 0.0555
Schistosoma mansoni serine/threonine kinase 0.0297 0.0874 0.131
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0155 0.0206 0.0214
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0133 0.01 0.0127
Brugia malayi Protein kinase domain containing protein 0.0182 0.0332 0.0332
Entamoeba histolytica protein kinase, putative 0.0547 0.2053 0.9805
Schistosoma mansoni titin 0.0125 0.0064 0.0096
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.032 0.0982 0.4619
Brugia malayi Protein kinase domain containing protein 0.0408 0.1399 0.1399
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0145 0.0158 0.0436
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0165 0.0251 0.0261
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0255 0.0678 0.0861
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0157 0.0215 0.0215
Brugia malayi Immunoglobulin I-set domain containing protein 0.0125 0.0064 0.0064
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0391
Loa Loa (eye worm) hypothetical protein 0.0242 0.0615 0.0615
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Trypanosoma brucei protein kinase, putative 0.0147 0.0167 0.0315
Loa Loa (eye worm) hypothetical protein 0.0294 0.0861 0.0861
Trypanosoma cruzi casein kinase, putative 0.017 0.0276 0.1197
Entamoeba histolytica protein kinase domain containing protein 0.022 0.0511 0.2316
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0308 0.0461
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0549 0.2063 0.2063
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0287 0.0829 0.4739
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0484 0.1758 0.1825
Brugia malayi Protein kinase domain containing protein 0.0596 0.2285 0.2285
Schistosoma mansoni serine/threonine protein kinase 0.1526 0.6675 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0177 0.0308 0.0319
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0474 0.171 0.2172
Onchocerca volvulus 0.0125 0.0064 0.0072
Loa Loa (eye worm) hypothetical protein 0.0456 0.1624 0.1624
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0169 0.027 0.027
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.013 0.0087 0.0111
Leishmania major protein kinase A catalytic subunit 0.0177 0.0308 0.1022
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0177 0.0308 0.1022
Schistosoma mansoni tyrosine kinase 0.0252 0.0663 0.0994
Loa Loa (eye worm) hypothetical protein 0.0211 0.0471 0.0471
Brugia malayi casein kinase 1, delta 0.017 0.0276 0.0276
Echinococcus multilocularis tyrosine protein kinase HCK 0.0248 0.0643 0.0817
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0162 0.0238 0.0987
Loa Loa (eye worm) hypothetical protein 0.0224 0.0529 0.0529
Plasmodium falciparum calcium-dependent protein kinase 4 0.0145 0.0158 0.035
Trichomonas vaginalis AGC family protein kinase 0.0547 0.2053 0.9808
Echinococcus granulosus neuroglian 0.013 0.0086 0.0089
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0413 0.1423 0.1423
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0624 0.2418 0.3071
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.017 0.0276 0.0276
Brugia malayi intracellular kinase 0.0255 0.0678 0.0678
Loa Loa (eye worm) TK/ROR protein kinase 0.0149 0.0178 0.0178
Brugia malayi Protein kinase domain containing protein 0.0463 0.1657 0.1657
Loa Loa (eye worm) hypothetical protein 0.0112 0.0003 0.0003
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0549 0.2063 0.2309
Giardia lamblia Kinase, STE STE20 0.0162 0.0238 0.067
Loa Loa (eye worm) AGC/PKA protein kinase 0.0177 0.0308 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0542 0.2033 0.2583
Echinococcus multilocularis mitogen activated protein kinase 14 0.032 0.0982 0.1248
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0104 0.0156
Plasmodium falciparum protein serine/threonine kinase-1 0.0172 0.0283 0.1169
Echinococcus multilocularis cyclin dependent kinase 5 0.0234 0.0579 0.0736
Echinococcus granulosus roundabout 2 0.013 0.0086 0.0089
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.013 0.0086 0.0086
Schistosoma mansoni tyrosine kinase 0.0395 0.1339 0.2006
Echinococcus multilocularis serine:threonine protein kinase N2 0.0425 0.1478 0.1878
Loa Loa (eye worm) hypothetical protein 0.0242 0.0615 0.0615
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0338 0.1068 0.1068
Echinococcus granulosus c-Jun N-terminal kinases 0.0542 0.2033 0.2111
Schistosoma mansoni serine/threonine protein kinase 0.0511 0.1884 0.2823
Echinococcus granulosus casein kinase i 0.017 0.0276 0.0286
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.0086 0.0086
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0666 0.2618 0.3326
Schistosoma mansoni adapter molecule crk 0.0158 0.0217 0.0325
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0851 0.3488 0.3621
Schistosoma mansoni growth factor receptor-bound protein 0.0159 0.0226 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.0308 0.0461
Brugia malayi Protein kinase domain containing protein 0.0399 0.1355 0.1355
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Entamoeba histolytica cell division protein kinase 2, putative 0.0234 0.0579 0.2645
Loa Loa (eye worm) hypothetical protein 0.0112 0.0004 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Echinococcus granulosus casein kinase I alpha 0.017 0.0276 0.0286
Echinococcus granulosus titin 0.0125 0.0064 0.0067
Entamoeba histolytica PH domain containing protein kinase, putative 0.0302 0.09 0.4205
Leishmania major protein kinase, putative 0.0172 0.0283 0.0899
Loa Loa (eye worm) AUR protein kinase 0.0458 0.1634 0.1634
Schistosoma mansoni serine/threonine protein kinase 0.023 0.0561 0.084
Echinococcus multilocularis titin 0.0125 0.0064 0.0082
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.0167 0.0644
Plasmodium vivax serine/threonine kinase-1, putative 0.0172 0.0283 0.1646
Echinococcus granulosus calcium activated potassium channel 0.0222 0.0522 0.0542
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0177 0.0308 0.1022
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0255 0.0678 0.1016
Brugia malayi Protein kinase domain containing protein 0.0547 0.2053 0.2053
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Loa Loa (eye worm) casein kinase 0.0178 0.0314 0.0314
Brugia malayi Peroxidasin 0.0112 0.0003 0.0003
Schistosoma mansoni protein kinase 0.0195 0.0392 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0229 0.1074
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0229 0.1074
Brugia malayi putative serine/threonine kinase SADA gamma 0.0134 0.0104 0.0104
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0338 0.1067 0.1108
Echinococcus multilocularis neuroglian 0.0278 0.0787 0.0999
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Leishmania major protein kinase, putative 0.0162 0.0238 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0612 0.2363 0.2363
Plasmodium falciparum casein kinase 1 0.017 0.0276 0.112
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0145 0.0158 0.0871
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.038 0.1267 0.1316
Schistosoma mansoni unc-13 (munc13) 0.013 0.0087 0.0131
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.038 0.1267 0.161
Trichomonas vaginalis CMGC family protein kinase 0.0234 0.0579 0.2752
Schistosoma mansoni serine/threonine protein kinase 0.0425 0.1478 0.2215
Onchocerca volvulus 0.0361 0.1176 0.1316
Leishmania major protein kinase, putative 0.0147 0.0167 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0303 0.0905 0.431
Schistosoma mansoni protein kinase C mu 0.0413 0.1423 0.2132
Echinococcus granulosus C2 calcium dependent membrane targeting 0.013 0.0087 0.0091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0405 0.1386 0.1761
Brugia malayi Kinase associated domain 1 family protein 0.017 0.0275 0.0275
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0255 0.0678 0.0678
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Entamoeba histolytica protein kinase domain containing protein 0.0255 0.0678 0.3124
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.0283 0.1336
Schistosoma mansoni hypothetical protein 0.017 0.0275 0.0412
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0162 0.0238 0.0987
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0229 0.1074
Trypanosoma brucei polo-like protein kinase 0.0555 0.2094 1
Schistosoma mansoni vesicular amine transporter 0.0224 0.0529 0.0793
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0195 0.0392 0.0392
Echinococcus multilocularis casein kinase I alpha 0.017 0.0276 0.035
Loa Loa (eye worm) hypothetical protein 0.0421 0.1462 0.1462
Brugia malayi protein-tyrosine kinase 0.0338 0.1067 0.1067
Brugia malayi map kinase activated protein kinase protein 2 0.0818 0.3332 0.3332
Entamoeba histolytica protein kinase, putative 0.0165 0.0251 0.1053
Brugia malayi Variant SH3 domain containing protein 0.0217 0.0499 0.0499
Loa Loa (eye worm) thyroid receptor interactor 0.0142 0.0146 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0458 0.1634 0.78
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.026 0.0699 0.0726
Echinococcus granulosus cyclin dependent kinase 0.0234 0.0579 0.0601
Brugia malayi Protein kinase domain containing protein 0.023 0.0561 0.0561
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0474 0.171 0.1775
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0476 0.1722 0.2187
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0858 0.3522 0.3522
Brugia malayi serine/threonine kinase 12 0.0458 0.1634 0.1634
Trypanosoma cruzi cdc2-related kinase 1 0.0234 0.0579 0.2667
Brugia malayi Protein kinase domain containing protein 0.0185 0.0344 0.0344
Echinococcus multilocularis neuroglian 0.013 0.0086 0.0109
Brugia malayi hypothetical protein 0.0239 0.0603 0.0603
Schistosoma mansoni cell adhesion molecule 0.013 0.0086 0.0129
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0147 0.0167 0.0484
Brugia malayi Protein kinase domain containing protein 0.0155 0.0206 0.0206
Schistosoma mansoni tyrosine kinase 0.0405 0.1386 0.2077
Echinococcus multilocularis PAK box P21 Rho binding 0.0119 0.0035 0.0044
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0818 0.3332 0.346
Brugia malayi Tyrosine-protein kinase abl-1 0.042 0.1456 0.1456
Schistosoma mansoni serine/threonine protein kinase 0.0818 0.3332 0.4992
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0549 0.2063 0.2063
Brugia malayi Ras association domain family 1 isoform A 0.0127 0.0075 0.0075
Echinococcus multilocularis calcium activated potassium channel 0.0222 0.0522 0.0663
Trichomonas vaginalis CMGC family protein kinase 0.016 0.0229 0.1074
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0216 0.0495 0.0513
Loa Loa (eye worm) hypothetical protein 0.0158 0.0217 0.0217
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0946 0.0946
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0555 0.2094 1
Brugia malayi Protein kinase domain containing protein 0.0331 0.1037 0.1037
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.013 0.0086 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0555 0.2094 0.3136
Loa Loa (eye worm) AUR protein kinase 0.0458 0.1634 0.1634
Brugia malayi casein kinase I 0.017 0.0276 0.0276
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0542 0.2033 0.2033
Loa Loa (eye worm) hypothetical protein 0.0224 0.0532 0.0532
Echinococcus multilocularis Rac GTPase activating protein 1 0.0127 0.0075 0.0095
Leishmania major protein kinase A catalytic subunit isoform 2 0.0177 0.0308 0.1022
Loa Loa (eye worm) hypothetical protein 0.0237 0.0591 0.0591
Entamoeba histolytica protein kinase domain containing protein 0.0195 0.0392 0.1738
Echinococcus granulosus contactin 0.013 0.0086 0.0089
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1464 0.6382 0.6382
Echinococcus multilocularis casein kinase I alpha 0.017 0.0276 0.035
Echinococcus multilocularis mitogen activated protein kinase 0.016 0.0229 0.029
Brugia malayi Protein kinase domain containing protein 0.0303 0.0905 0.0905
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0133 0.01 0.0103
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0234 0.0579 0.0579
Schistosoma mansoni protein kinase 0.0165 0.0251 0.0377
Plasmodium falciparum serine/threonine protein kinase, putative 0.0458 0.1634 1
Entamoeba histolytica protein kinase domain containing protein 0.0242 0.0614 0.2812
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Loa Loa (eye worm) TK/INSR protein kinase 0.0947 0.3944 0.3944
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0157 0.0215 0.0903
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0458 0.1634 0.2075
Echinococcus multilocularis casein kinase ii subunit alpha 0.0195 0.0392 0.0498
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0283 0.0424
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0394 0.1333 0.1694
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0515 0.1902 0.1975
Echinococcus multilocularis peroxidasin 0.0112 0.0003 0.0003
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0405 0.1386 0.1439
Schistosoma mansoni tyrosine kinase 0.0515 0.1902 0.285
Schistosoma mansoni serine/threonine protein kinase 0.0549 0.2063 0.3091
Echinococcus multilocularis hypothetical protein 0.017 0.0275 0.0349
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0484 0.1758 0.2233
Echinococcus multilocularis serine:threonine protein kinase 38 0.0297 0.0874 0.111
Echinococcus multilocularis rac serine:threonine kinase 0.0302 0.09 0.1144
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0177 0.0308 0.1022
Brugia malayi RhoGAP domain containing protein 0.0217 0.0499 0.0499
Trichomonas vaginalis CK1 family protein kinase 0.017 0.0276 0.13
Echinococcus multilocularis casein kinase I delta 0.017 0.0276 0.035
Schistosoma mansoni protein kinase 0.0458 0.1634 0.2448
Loa Loa (eye worm) AGC/PKA protein kinase 0.0177 0.0308 0.0308
Echinococcus granulosus cyclin dependent kinase 5 0.0234 0.0579 0.0601
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0242 0.0614 0.0614
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0217 0.0499 0.0518
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Schistosoma mansoni serine/threonine protein kinase 0.017 0.0276 0.0413
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0239 0.0603 0.0626
Brugia malayi Pleckstrin Homology Domain 0.0142 0.0146 0.0146
Brugia malayi STE20-like kinase MST 0.0527 0.1959 0.1959
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0255 0.0678 0.3161
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Brugia malayi Protein kinase domain containing protein 0.0185 0.0344 0.0344
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0297 0.0874 0.0907
Giardia lamblia Kinase, NEK 0.0271 0.0753 0.3258
Trypanosoma brucei rac serine-threonine kinase, putative 0.0547 0.2053 0.9799
Plasmodium falciparum calcium-dependent protein kinase 1 0.0145 0.0158 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0255 0.0678 0.3224
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0206 0.0966
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0946 0.4506
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0217 0.0499 0.0748
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0182 0.0332 0.0332
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.013 0.0086 0.0129
Plasmodium vivax unspecified product 0.0195 0.0392 0.2321
Onchocerca volvulus Serine\/threonine kinase homolog 0.0182 0.0332 0.0372
Loa Loa (eye worm) hypothetical protein 0.0376 0.1247 0.1247
Loa Loa (eye worm) hypothetical protein 0.0389 0.1312 0.1312
Trichomonas vaginalis AGC family protein kinase 0.0177 0.0308 0.1453
Echinococcus granulosus cyclin dependent kinase 1 0.0234 0.0579 0.0601
Echinococcus multilocularis protein kinase c iota type 0.06 0.2304 0.2926
Echinococcus multilocularis myosin iiia 0.0162 0.0238 0.0302
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Echinococcus multilocularis dual specificity 0.0157 0.0215 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0195 0.0392 0.1858
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0338 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0189 0.0366 0.0366
Trichomonas vaginalis STE family protein kinase 0.0165 0.0251 0.1183
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0287 0.0829 0.5023
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0165 0.0251 0.0261
Onchocerca volvulus Tyrosine kinase homolog 0.2005 0.8934 1
Echinococcus multilocularis dual specificity 0.0157 0.0215 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.0215 0.0322
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0265 0.0722 0.3437
Loa Loa (eye worm) hypothetical protein 0.0136 0.0114 0.0114
Loa Loa (eye worm) TK protein kinase 0.0248 0.0643 0.0643
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0579 0.0868
Trichomonas vaginalis CMGC family protein kinase 0.0157 0.0215 0.1009
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.016 0.0229 0.0624
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0224 0.0529 0.0793
Echinococcus granulosus cGMP dependent protein kinase 0.0153 0.0194 0.0202
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0818 0.3332 0.3332
Echinococcus granulosus aurora kinase A 0.0458 0.1634 0.1696
Echinococcus multilocularis tyrosine protein kinase Srms 0.0338 0.1067 0.1356
Brugia malayi Protein kinase domain containing protein 0.0224 0.0532 0.0532
Schistosoma mansoni kinase 0.0594 0.2278 0.3413
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0145 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0205 0.0439 0.0658
Trypanosoma cruzi aurora B kinase, putative 0.0458 0.1634 0.7774
Brugia malayi MAP kinase sur-1 0.016 0.0229 0.0229
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0127 0.0075 0.0075
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0458 0.1634 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0511 0.1884 0.2393
Schistosoma mansoni protein kinase 0.0476 0.1722 0.2579
Onchocerca volvulus 0.0294 0.0861 0.0964
Echinococcus granulosus protein kinase c epsilon type 0.0427 0.1488 0.1545
Loa Loa (eye worm) hypothetical protein 0.0134 0.0104 0.0104
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.016 0.0229 0.0969
Trichomonas vaginalis CAMK family protein kinase 0.0555 0.2094 1
Echinococcus granulosus tyrosine kinase 0.0338 0.1067 0.1108
Loa Loa (eye worm) TK/ABL protein kinase 0.0624 0.2418 0.2418
Loa Loa (eye worm) hypothetical protein 0.0127 0.0075 0.0075
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0145 0.0158 0.0201
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0124 0.0061 0.0077
Echinococcus granulosus Rac GTPase activating protein 1 0.0127 0.0075 0.0078
Entamoeba histolytica protein kinase, putative 0.0242 0.0614 0.2812
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0185 0.0344 0.1505
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0338 0.1068 0.1357
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0134 0.0104 0.0133
Brugia malayi Protein kinase domain containing protein 0.0612 0.2363 0.2363
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0157 0.0215 0.0734
Echinococcus multilocularis 0.0119 0.0036 0.0046
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0172 0.0283 0.0899
Loa Loa (eye worm) hypothetical protein 0.0389 0.1312 0.1312
Schistosoma mansoni serine/threonine protein kinase 0.0427 0.1488 0.2229
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0439 0.2083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0338 0.1067 0.1356
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0125 0.0064 0.0064
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0475 0.1715 0.178
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0224 0.0532 0.0532
Brugia malayi Protein kinase domain containing protein 0.0947 0.3944 0.3944
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0177 0.0308 0.0308
Echinococcus granulosus serine threonine protein kinase nrc 0.0287 0.0829 0.0861
Plasmodium falciparum cGMP-dependent protein kinase 0.0153 0.0194 0.0589
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0555 0.2094 0.2094
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0549 0.2063 0.2063
Schistosoma mansoni protein kinase 0.0171 0.0281 0.0421
Echinococcus granulosus serine:threonine kinase SAD 1 0.0134 0.0104 0.0108
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.021 0.0466 0.0466
Echinococcus granulosus serine:threonine protein kinase N2 0.0425 0.1478 0.1535
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0104 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.1068 0.16
Trypanosoma cruzi casein kinase, putative 0.017 0.0276 0.1197
Loa Loa (eye worm) SRC-1 0.0405 0.1386 0.1386
Schistosoma mansoni protein kinase 0.0476 0.1722 0.2579
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0155 0.0206 0.0262
Brugia malayi Casein kinase II, alpha chain 0.0195 0.0392 0.0392
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0177 0.0308 0.1352
Echinococcus multilocularis insulin receptor 0.0947 0.3944 0.5009
Toxoplasma gondii CMGC kinase, CK2 family 0.0195 0.0392 0.1664
Echinococcus granulosus ephrin type A receptor 4 A 0.023 0.056 0.0581
Schistosoma mansoni vav2 0.0232 0.057 0.0854
Echinococcus granulosus tyrosine protein kinase Srms 0.0587 0.2244 0.233
Brugia malayi Protein kinase domain 0.0165 0.0251 0.0251
Echinococcus granulosus fibroblast growth factor receptor 4 0.0515 0.1902 0.1975
Brugia malayi Protein kinase domain containing protein 0.06 0.2306 0.2306
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.1715 0.2569
Entamoeba histolytica hypothetical protein 0.0127 0.0075 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0522 0.0782
Schistosoma mansoni tyrosine kinase 0.0601 0.2309 0.3459
Loa Loa (eye worm) TK/FER protein kinase 0.0185 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.017 0.0275 0.0412
Echinococcus multilocularis casein kinase I delta 0.017 0.0276 0.035
Echinococcus granulosus protein kinase c eta type 0.0127 0.0075 0.0078
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0246 0.0633 0.2657
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0338 0.1068 0.1109
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0287 0.0829 0.3878
Loa Loa (eye worm) TK/FAK protein kinase 0.06 0.2306 0.2306
Entamoeba histolytica PH domain containing protein kinase, putative 0.0192 0.0379 0.1672
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0522 0.0782
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0408 0.1399 0.1399
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0508 0.1871 0.1942
Echinococcus granulosus nervana 2 0.0235 0.0582 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0332 0.0497
Giardia lamblia Kinase, CMGC GSK 0.0255 0.0678 0.2883
Echinococcus multilocularis dual specificity protein kinase clk2 0.0172 0.0283 0.036
Echinococcus granulosus Protein kinase C brain isozyme 0.0511 0.1884 0.1956
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0206 0.0309

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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