Detailed information for compound 145393

Basic information

Technical information
  • TDR Targets ID: 145393
  • Name: (3Z)-4-methyl-3-[(4-morpholin-4-ylphenyl)meth ylidene]-1H-indol-2-one
  • MW: 320.385 | Formula: C20H20N2O2
  • H donors: 1 H acceptors: 1 LogP: 3.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(/C/1=C/c1ccc(cc1)N1CCOCC1)c(C)ccc2
  • InChi: 1S/C20H20N2O2/c1-14-3-2-4-18-19(14)17(20(23)21-18)13-15-5-7-16(8-6-15)22-9-11-24-12-10-22/h2-8,13H,9-12H2,1H3,(H,21,23)/b17-13-
  • InChiKey: KBPBXFBACWNRGQ-LGMDPLHJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3Z)-4-methyl-3-[(4-morpholinophenyl)methylene]indolin-2-one
  • (3Z)-4-methyl-3-[(4-morpholinophenyl)methylene]-2-indolinone
  • (3Z)-4-methyl-3-(4-morpholinobenzylidene)oxindole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus kinase insert domain protein receptor Starlite/ChEMBL References
Mus musculus FMS-like tyrosine kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.005 0.0093 0.0982
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0003 0.0016
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0024 0.0257
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0001 0.0003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0049 0.096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0105
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0135 0.0864
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0092 0.0188 0.1202
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0203 0.0436 0.0434
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0097 0.0198 1
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0075 0.0149 0.0953
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0013 0.0008 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.005 0.0093 0.0594
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0124 0.1317
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0097 0.0198 0.1266
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0013 0.0008 0.0089
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0003 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Echinococcus multilocularis expressed protein 0.0388 0.0854 0.5466
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0702 0.1562 1
Mycobacterium ulcerans phosphoglycerate kinase 0.0094 0.0191 0.018
Echinococcus granulosus phosphoglycerate kinase 1 0.0094 0.0191 0.1223
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0012 0.013
Leishmania major DNA damage repair protein, putative 0.0016 0.0015 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0027
Plasmodium vivax phosphoglycerate kinase, putative 0.0094 0.0191 0.8745
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0069 0.0135 0.6201
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0092 0.0188 0.947
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0024 0.0257
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0135 0.6709
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0081 0.1159
Echinococcus multilocularis integrin alpha ps 0.0013 0.0009 0.0059
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0203 0.0436 0.0426
Echinococcus multilocularis dna polymerase eta 0.0064 0.0124 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0058 0.2662
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Plasmodium vivax glutathione reductase, putative 0.0089 0.018 0.8204
Schistosoma mansoni integrin alpha 0.0028 0.0042 0.0266
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0092 0.0188 0.1985
Mycobacterium tuberculosis Probable oxidoreductase 0.0225 0.0487 0.0477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0016 0.0379
Mycobacterium ulcerans isocitrate lyase AceAb 0.4444 1 1
Schistosoma mansoni peptidase 0.0013 0.0008 0.0054
Echinococcus multilocularis netrin receptor unc 5 0.0024 0.0035 0.0221
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0135 0.6709
Onchocerca volvulus 0.0014 0.0011 0.0094
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0031 0.0372
Trypanosoma brucei Carboxypeptidase-like protein 0.0013 0.0008 0.0089
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0024 0.0257
Leishmania major phosphoglycerate kinase B, cytosolic 0.0094 0.0191 0.9647
Echinococcus granulosus aldehyde reductase 0.001 0.0002 0.0013
Trichomonas vaginalis glutaminase, putative 0.0151 0.0319 0.4863
Leishmania major DNA polymerase eta, putative 0.003 0.0046 0.2068
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0005
Echinococcus multilocularis roundabout 2 0.0016 0.0016 0.0104
Schistosoma mansoni cell adhesion molecule 0.0016 0.0016 0.0104
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0003 0.0016
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0081 0.3896
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0092 0.0188 0.947
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Echinococcus granulosus axis inhibition protein axin 0.002 0.0024 0.0155
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.0649 1
Echinococcus granulosus tyrosine protein kinase otk 0.0016 0.0016 0.0104
Echinococcus granulosus lamin 0.0029 0.0044 0.0283
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.005 0.0093 0.4505
Loa Loa (eye worm) oxidoreductase 0.0014 0.0011 0.012
Echinococcus multilocularis lamin 0.0029 0.0044 0.0283
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0156 0.1001
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0032 0.0052 0.2355
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Brugia malayi glutathione reductase 0.0089 0.018 0.1901
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0014 0.0011 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0016 0.0171
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0063 0.0122 0.5606
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0093 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0084 0.0539
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0132 0.1392
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0024 0.0155
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0013 0.0008 0.0366
Loa Loa (eye worm) integrin alpha pat-2 0.0061 0.0117 0.1235
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0013 0.0008 0.0054
Echinococcus granulosus microtubule associated protein 2 0.0702 0.1562 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0016 0.0171
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0087 0.0917
Echinococcus granulosus cpg binding protein 0.0032 0.0052 0.0335
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0147
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0015 0.0409
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0105
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Onchocerca volvulus 0.0014 0.0011 0.0094
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0016 0.0016 0.01
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Brugia malayi polk-prov protein 0.0016 0.0015 0.0154
Schistosoma mansoni peptidase 0.0013 0.0008 0.0054
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0045 0.0081 0.3896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0104
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0053 0.0098 0.0628
Echinococcus granulosus tar DNA binding protein 0.0068 0.0132 0.0843
Echinococcus granulosus peroxidasin 0.0016 0.0016 0.0104
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.001 0.0001 0.0008
Echinococcus multilocularis integrin alpha ps 0.0028 0.0042 0.0266
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0003 0.0016
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0104
Schistosoma mansoni lamin 0.0029 0.0044 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0455
Trichomonas vaginalis aldo/keto reductase, putative 0.0014 0.0011 0.0072
Loa Loa (eye worm) hypothetical protein 0.0045 0.0081 0.086
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0084 0.0891
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0049 0.0037
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0013 0.0008 0.0089
Trypanosoma brucei aldo-keto reductase, putative 0.0014 0.0011 0.0241
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0181 0.1158
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Leishmania major phosphoglycerate kinase C, glycosomal 0.0094 0.0191 0.9647
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0092 0.0188 0.1202
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0013 0.0008 0.0063
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0094 0.0191 0.2867
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0049 0.0654
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0015 0.0293
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0203 0.0436 0.0426
Schistosoma mansoni DNA helicase recq5 0.0009 0.0001 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0028 0.0291
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0024 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0015 0.0409
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0063 0.0122 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0124
Echinococcus granulosus lamin dm0 0.0029 0.0044 0.0283
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Brugia malayi Integrin alpha pat-2 precursor 0.0028 0.0042 0.044
Entamoeba histolytica hypothetical protein 0.0024 0.0033 0.0408
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0097 0.0198 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0015 0.0648
Schistosoma mansoni cell adhesion molecule 0.0016 0.0016 0.0104
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0007
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0013 0.0008 0.0366
Loa Loa (eye worm) zinc carboxypeptidase 0.0013 0.0008 0.0089
Plasmodium falciparum phd finger protein, putative 0.0016 0.0016 0.0696
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0001 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0539
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0093 0.4505
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.4444 1 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0044 0.0467
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0014 0.0089
Loa Loa (eye worm) glutaminase 0.0151 0.0319 0.3378
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0024 0.0257
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0028 0.1089
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0094 0.0191 0.2867
Echinococcus multilocularis lachesin 0.0016 0.0016 0.0104
Loa Loa (eye worm) oxidoreductase 0.0014 0.0011 0.012
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0014 0.0011 0.012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.003 0.0321
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0013 0.0008 0.0122
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0428 0.0945 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.005 0.0093 0.0082
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0069 0.0135 0.6449
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0053 0.0098 0.0628
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0049 0.2201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0172
Trypanosoma brucei unspecified product 0.0035 0.0058 0.2662
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Onchocerca volvulus Netrin receptor homolog 0.0022 0.003 0.0294
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0155
Echinococcus granulosus dna polymerase kappa 0.005 0.0093 0.0594
Brugia malayi fructose-bisphosphate aldolase 1 0.0092 0.0188 0.1985
Echinococcus granulosus expressed protein 0.0388 0.0854 0.5466
Brugia malayi Carboxypeptidase A2 precursor 0.0013 0.0008 0.0089
Echinococcus multilocularis dna polymerase kappa 0.005 0.0093 0.0594
Schistosoma mansoni glutaminase 0.0151 0.0319 0.2045
Schistosoma mansoni aldo-keto reductase 0.0014 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.01
Onchocerca volvulus Tyrosine kinase homolog 0.0426 0.0941 1
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0013 0.0008 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0003 0.0027
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0092 0.0188 0.8584
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0092 0.0188 0.1202
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0044 0.0467
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0049 0.1932
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0058 0.2662
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0016 0.0104
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0014 0.0149
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0014 0.0011 0.0072
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0027
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0016 0.0173
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0214
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0013 0.0008 0.0122
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0015 0.0093
Loa Loa (eye worm) hypothetical protein 0.0064 0.0124 0.1317
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0014 0.0011 0.012
Onchocerca volvulus 0.0417 0.0919 0.9766
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0649 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0001 0.0003
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0097 0.0198 0.2673
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0003 0.0016
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0014 0.0011 0.0072
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0081 0.086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0104
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0081 0.3896
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0016
Loa Loa (eye worm) TK protein kinase 0.001 0.0001 0.0014
Brugia malayi Peroxidasin 0.0016 0.0016 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0033 0.1373
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0075 0.0149 0.0953
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0016 0.0503
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0165
Schistosoma mansoni septate junction protein 0.0016 0.0016 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Brugia malayi intermediate filament protein 0.0029 0.0044 0.0467
Loa Loa (eye worm) oxidoreductase 0.0014 0.0011 0.012
Mycobacterium ulcerans glutaminase 0.0151 0.0319 0.0308
Echinococcus multilocularis integrin alpha 3 0.0013 0.0009 0.0059
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0013 0.0008 0.0122
Trypanosoma cruzi Carboxypeptidase-like protein 0.0013 0.0008 0.0089
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0015 0.0409
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0015 0.0648
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0024 0.0155
Trichomonas vaginalis aldo/keto reductase, putative 0.0014 0.0011 0.0072
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0024 0.0257
Brugia malayi TAR-binding protein 0.0068 0.0132 0.1392
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0024 0.0155
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0049 0.2227
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0097
Schistosoma mansoni pol-related 0.0014 0.0011 0.0073
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0156 0.1001
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0015 0.0409
Loa Loa (eye worm) hypothetical protein 0.0052 0.0096 0.1017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0027
Treponema pallidum phosphoglycerate kinase 0.0094 0.0191 0.2563
Echinococcus granulosus axis inhibition protein axin 0.002 0.0024 0.0155
Echinococcus granulosus bloom syndrome protein 0.0023 0.0031 0.0196
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0124 0.6164
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Onchocerca volvulus 0.0029 0.0044 0.0444
Entamoeba histolytica aldose reductase, putative 0.0014 0.0011 0.0072
Toxoplasma gondii thioredoxin reductase 0.0089 0.018 0.827
Mycobacterium leprae Isocitrate lyase 0.2083 0.4677 0.4675
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0016
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0155
Brugia malayi jmjC domain containing protein 0.0053 0.0098 0.1038
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.4444 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0027
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0024 0.0155
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.012
Entamoeba histolytica hypothetical protein 0.002 0.0024 0.0272
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.0649 1
Echinococcus multilocularis aldo keto reductase 0.0014 0.0011 0.0073
Echinococcus multilocularis jumonji domain containing protein 0.0022 0.003 0.0191
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0003 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0049 0.2201
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0092 0.0188 0.947
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0049 0.0312
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0105 0.0217 0.3339
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0503
Onchocerca volvulus Alhambra homolog 0.0016 0.0016 0.0139
Schistosoma mansoni protease m14 carboxypeptidase 0.0013 0.0008 0.0054
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0027 0.0287
Schistosoma mansoni tyrosine kinase 0.0019 0.0022 0.014
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0105 0.0217 1
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0049 0.2227
Echinococcus multilocularis musashi 0.0029 0.0044 0.0283
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0092 0.0188 0.1202
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0058 0.2662
Schistosoma mansoni hypothetical protein 0.0348 0.0765 0.4897
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0092 0.0188 0.1202
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0081 0.1243
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0024 0.0155
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0097 0.0198 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0135 0.0864
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0649 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Echinococcus granulosus roundabout 2 0.0016 0.0016 0.0104
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0016 0.0503
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0049 0.0037
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0001 0.0003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0049 0.1001
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0034 0.0057 0.2633
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0016 0.0016 0.0104
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0024 0.0155
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0003 0.0016
Echinococcus granulosus roundabout 2 0.0016 0.0016 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Echinococcus granulosus intermediate filament protein 0.0029 0.0044 0.0283
Brugia malayi PHD-finger family protein 0.0016 0.0016 0.0165
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0016
Brugia malayi Protein kinase domain containing protein 0.0015 0.0014 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0024 0.0033 0.0408
Echinococcus granulosus aldo keto reductase 0.0014 0.0011 0.0073
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0014 0.0011 0.0241
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0024 0.0155
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Entamoeba histolytica deoxycytidyl transferase, putative 0.005 0.0093 0.1339
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0027
Chlamydia trachomatis phosphoglycerate kinase 0.0094 0.0191 0.959
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Mycobacterium ulcerans isocitrate lyase Icl 0.4444 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.00000000044488
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0027
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0172
Echinococcus multilocularis aldo keto reductase 0.0014 0.0011 0.0073
Onchocerca volvulus Carboxypeptidase D homolog 0.0013 0.0008 0.0063
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0428 0.0945 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0003 0.0016
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0014 0.0091
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.017 0.1798
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Schistosoma mansoni titin 0.0016 0.0016 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0731
Entamoeba histolytica hypothetical protein 0.002 0.0024 0.0272
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0135 0.0864
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Brugia malayi steroid hormone receptor 0.001 0.0003 0.0027
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0105 0.0217 0.3274
Loa Loa (eye worm) hypothetical protein 0.0085 0.017 0.1798
Echinococcus granulosus FTZ F1 alpha 0.001 0.0003 0.0016
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0097 0.0198 0.0187
Schistosoma mansoni cell adhesion molecule 0.0016 0.0016 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0049 0.0312
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0016
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Echinococcus multilocularis integrin alpha ps 0.0028 0.0042 0.0266
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0069 0.0135 0.1653
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0016 0.0016 0.0104
Loa Loa (eye worm) RecQ helicase 0.0023 0.0031 0.0324
Onchocerca volvulus 0.0014 0.0011 0.0094
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0046 0.211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Echinococcus multilocularis phosphoglycerate kinase 1 0.0094 0.0191 0.1223
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0013 0.0008 0.0089
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0031 0.005 0.2245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0027
Schistosoma mansoni hypothetical protein 0.0436 0.0962 0.6162
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0049 0.1932
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0084 0.0539
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0094 0.0191 0.9647
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Schistosoma mansoni coup transcription factor 0.001 0.0003 0.0016
Trypanosoma brucei phosphoglycerate kinase 0.0034 0.0057 0.2633
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0094 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0467
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0132 0.1392
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0049 0.0312
Plasmodium falciparum fructose-bisphosphate aldolase 0.0092 0.0188 0.8636
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0011 0.0068
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0203 0.0436 0.0426
Loa Loa (eye worm) hypothetical protein 0.0094 0.0191 0.2021
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0135 0.6185
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Schistosoma mansoni phosphoglycerate kinase 0.0094 0.0191 0.1223
Onchocerca volvulus 0.0075 0.0149 0.156
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0092 0.0188 0.8636
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0093 0.4505
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0013 0.0008 0.0089
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0135 0.6709
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0016 0.0016 0.0104
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.6709
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0069 0.0135 0.0124
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0093 0.1339
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Brugia malayi Thioredoxin reductase 0.0089 0.018 0.1901
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0008 0.0053
Giardia lamblia Aldose reductase 0.0014 0.0011 0.0167
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0013 0.0008 0.0054
Giardia lamblia DNA damage repair protein 0.0016 0.0015 0.0216
Schistosoma mansoni cpg binding protein 0.0032 0.0052 0.0335
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0092 0.0188 0.8636
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0049 0.0744
Loa Loa (eye worm) oxidoreductase 0.0014 0.0011 0.012
Brugia malayi Prion-like- 0.0016 0.0016 0.0171
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0092 0.0188 0.1202
Echinococcus multilocularis hemicentin 1 0.0016 0.0016 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0093 0.4505
Schistosoma mansoni neuroglian 0.0016 0.0016 0.0104
Trichomonas vaginalis aldo/keto reductase, putative 0.0014 0.0011 0.0072
Schistosoma mansoni phosphoglycerate kinase 0.0094 0.0191 0.1223
Echinococcus multilocularis 0.0013 0.0008 0.0054
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0069 0.0135 0.6201
Echinococcus multilocularis PHD finger protein rhinoceros 0.0016 0.0016 0.01
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0003 0.0027
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0135 0.2071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0154
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0024 0.0155
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0155
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0024 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0003 0.0016
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0027
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Echinococcus granulosus contactin 0.0016 0.0016 0.0104
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0031 0.0372
Brugia malayi PXA domain containing protein 0.002 0.0024 0.0257
Brugia malayi glucose-6-phosphate dehydrogenase 0.0097 0.0198 0.2092
Onchocerca volvulus 0.0085 0.017 0.1785
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.005 0.0093 0.0082
Entamoeba histolytica phosphoglycerate kinase, putative 0.0094 0.0191 0.2867
Echinococcus granulosus aldo keto reductase 0.0014 0.0011 0.0073
Leishmania major DNA polymerase eta, putative 0.0064 0.0124 0.6164
Echinococcus granulosus lachesin 0.0016 0.0016 0.0104
Trypanosoma cruzi aldo/keto reductase, putative 0.0014 0.0011 0.0241
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.005 0.0093 0.0594
Plasmodium falciparum thioredoxin reductase 0.0031 0.0049 0.2227
Giardia lamblia DINP protein human, muc B family 0.005 0.0093 0.1422
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0135 0.6709
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0024 0.0155
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0046 0.2068
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0024 0.0155
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Echinococcus multilocularis geminin 0.0348 0.0765 0.4897
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.01
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.002 0.0127
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0024 0.0155
Brugia malayi RNA binding protein 0.0068 0.0132 0.1392
Trypanosoma brucei phosphoglycerate kinase 0.0094 0.0191 0.9647
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.015
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0013 0.0008 0.0054
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Onchocerca volvulus 0.0014 0.0011 0.0094
Echinococcus granulosus integrin alpha ps 0.0028 0.0042 0.0266
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0014 0.0089
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0024 0.0033 0.0349
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.6709
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0135 0.6709
Trypanosoma cruzi aldo-keto reductase 0.0014 0.0011 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0027
Echinococcus multilocularis roundabout 2 0.0016 0.0016 0.0104
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0044 0.0467
Schistosoma mansoni intermediate filament proteins 0.0029 0.0044 0.0283
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0104
Echinococcus granulosus geminin 0.0348 0.0765 0.4897
Entamoeba histolytica hypothetical protein 0.002 0.0024 0.0272
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.001 0.0001 0.0008
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0031 0.0196
Loa Loa (eye worm) hypothetical protein 0.0062 0.012 0.1267
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0135 0.0864
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0015 0.0409
Loa Loa (eye worm) glutaminase 2 0.0151 0.0319 0.3378
Brugia malayi ecdysteroid receptor 0.001 0.0003 0.0027
Leishmania major fructose-1,6-bisphosphate aldolase 0.0092 0.0188 0.947
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0033 0.1498
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0135 0.6201
Trypanosoma brucei trypanothione reductase 0.0089 0.018 0.9055
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0016 0.0016 0.0171
Echinococcus multilocularis aldehyde reductase 0.001 0.0002 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0033 0.0031
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0014 0.0011 0.0009
Echinococcus multilocularis tyrosine protein kinase otk 0.0016 0.0016 0.0104
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0409
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0124 0.6164
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0013 0.0008 0.0054
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0104
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0181 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0092 0.0188 0.947
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Plasmodium falciparum thioredoxin reductase 0.0089 0.018 0.827
Brugia malayi Uncoordinated protein 44 0.0015 0.0014 0.0147
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0024 0.1102
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0093 0.0982
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0132 0.1392
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0015 0.0409
Schistosoma mansoni roundabout 0.0016 0.0016 0.0104
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0015 0.0409
Brugia malayi hypothetical protein 0.002 0.0024 0.0257
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0048 0.0512
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0132 0.0843
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0015 0.0409
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0049 0.2201
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0014 0.0267
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0092 0.0188 0.1202
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0081 0.052
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0003 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0003 0.0016
Echinococcus granulosus integrin alpha ps 0.0013 0.0009 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0003 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0016 0.0173
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0094 0.0191 0.8791
Echinococcus multilocularis Ankyrin 0.0015 0.0014 0.0091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0203 0.0436 0.0426
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0013 0.0008 0.0054
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0084 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0003 0.0027
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0024 0.0272
Schistosoma mansoni DNA helicase recq1 0.0009 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0059 0.0379
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.018 0.9055
Brugia malayi isocitrate dehydrogenase 0.0016 0.0016 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0015 0.0409
Brugia malayi hypothetical protein 0.002 0.0024 0.0257
Toxoplasma gondii flagellar/basal body protein 0.0013 0.0008 0.0366
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0016 0.0343
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0155
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0094 0.0191 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0021 0.0027 0.0174
Giardia lamblia Phosphoglycerate kinase 0.0094 0.0191 0.2935
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0033 0.0031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0104
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0049 0.2201
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0049 0.2201
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.011 0.5057
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0096 0.1017
Brugia malayi glutaminase DH11.1 0.0151 0.0319 0.3378
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0081 0.1159
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0225 0.0487 0.0477
Loa Loa (eye worm) hypothetical protein 0.0047 0.0084 0.0892
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0003 0.0016
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0105 0.0217 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.4444 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0132 0.0843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0084 0.0539
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0016 0.0016 0.0104
Onchocerca volvulus 0.0013 0.0008 0.0063
Echinococcus multilocularis roundabout 2 0.0016 0.0016 0.0104
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0016 0.0016 0.0104
Echinococcus granulosus aldo keto reductase 0.0014 0.0011 0.0073
Onchocerca volvulus 0.0075 0.0149 0.156
Schistosoma mansoni axis inhibition protein axin 0.002 0.0024 0.0155
Schistosoma mansoni cpg binding protein 0.0031 0.0048 0.031
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0028 0.1089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Echinococcus granulosus dnaJ subfamily B 0.0436 0.0962 0.6162
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0097 0.0198 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0132 0.0843
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0094 0.0191 0.0189
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0003 0.0027
Schistosoma mansoni integrin alpha-ps 0.0028 0.0042 0.0266
Schistosoma mansoni regulator of G protein signaling 0.002 0.0024 0.0155
Onchocerca volvulus 0.0031 0.0048 0.0489
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0024 0.0155
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0024 0.0257
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0033 0.1373
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0097 0.0198 0.2092
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Schistosoma mansoni jumonji domain containing protein 0.0042 0.0074 0.0472
Schistosoma mansoni hypothetical protein 0.0013 0.0009 0.0059
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0016
Leishmania major prostaglandin f synthase, putative 0.0014 0.0011 0.0241
Schistosoma mansoni septate junction protein 0.0016 0.0016 0.0104
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0132 0.0843
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0135 0.6709
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0013 0.0008 0.0054
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0031 0.0324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0001 0.0014
Plasmodium falciparum phosphoglycerate kinase 0.0094 0.0191 0.8791
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0093 0.4505
Toxoplasma gondii PHD-finger domain-containing protein 0.0016 0.0016 0.0696
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0049 0.2201
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Echinococcus multilocularis microtubule associated protein 2 0.0702 0.1562 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0014 0.0011 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0016 0.0105
Giardia lamblia PHD finger protein 15 0.0016 0.0016 0.0233
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0081 0.052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.6709
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0105 0.0217 0.3274
Echinococcus multilocularis aldo keto reductase 0.0014 0.0011 0.0073
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0307 0.0296
Onchocerca volvulus 0.0029 0.0044 0.0444
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0013 0.0008 0.0089
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0016 0.0105
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Brugia malayi fructose-bisphosphate aldolase 2 0.0092 0.0188 0.1985
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0092 0.0188 0.947
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0104
Loa Loa (eye worm) thioredoxin reductase 0.0089 0.018 0.1901
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0024 0.0155
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0054 0.0574
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Echinococcus multilocularis peregrin 0.0016 0.0016 0.01
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0024 0.0155
Leishmania major aldo-keto reductase-like protein 0.0014 0.0011 0.0241
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0089 0.018 0.0169
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0155
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0011 0.0068
Leishmania major DNA polymerase kappa, putative 0.0016 0.0015 0.0409
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0105 0.0217 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0003 0.0027
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0135 0.6057
Entamoeba histolytica aldose reductase, putative 0.0014 0.0011 0.0072
Giardia lamblia Aldose reductase 0.0014 0.0011 0.0167
Echinococcus granulosus death domain containing protein 0.0015 0.0014 0.0089
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0094 0.0191 0.8791
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0003 0.0016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.0093 0.0594
Echinococcus multilocularis lysine specific demethylase 5A 0.0019 0.0023 0.0149
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0135 0.0864
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0013 0.0008 0.0054
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0047 0.0084 0.0892
Leishmania major DNA polymerase kappa, putative 0.005 0.0093 0.4505
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0003 0.0016
Entamoeba histolytica aldose reductase, putative 0.0014 0.0011 0.0072
Onchocerca volvulus 0.0013 0.0008 0.0063
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0013 0.0008 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0003 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0003 0.0016
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0024 0.0155
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0097 0.0198 0.1266
Loa Loa (eye worm) RGS-3 protein 0.002 0.0024 0.0257
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0016 0.0165
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.017 0.1089
Mycobacterium ulcerans hypothetical protein 0.0016 0.0015 0.0003
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.017 0.1089
Mycobacterium tuberculosis Probable dehydrogenase 0.0203 0.0436 0.0426
Echinococcus multilocularis cpg binding protein 0.0032 0.0052 0.0335
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0105 0.0217 0.3274
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0013 0.0008 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0539
Onchocerca volvulus 0.0075 0.0149 0.156
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0033 0.0022
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0024 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0003 0.0027
Onchocerca volvulus 0.0014 0.0011 0.0094
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0001 0.0005
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0016 0.0016 0.0104
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0084 0.0891
Schistosoma mansoni DNA polymerase eta 0.0064 0.0124 0.0797
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0097 0.0198 0.1266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0049 0.2227
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0014 0.0149
Schistosoma mansoni integrin alpha-ps 0.0014 0.0012 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0016 0.0731
Onchocerca volvulus 0.0075 0.0149 0.156
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0024 0.0257
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0003 0.0016
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0033 0.1498
Echinococcus multilocularis dnaJ subfamily B 0.0436 0.0962 0.6162
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0014 0.0011 0.0072
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0016 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0089 0.018 0.8204
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0049 0.2227
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0096 0.1017
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Trypanosoma brucei phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0049 0.2201
Echinococcus multilocularis lamin dm0 0.0029 0.0044 0.0283
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0054
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0016 0.0016 0.0145
Echinococcus multilocularis neuroglian 0.0016 0.0016 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0016 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0003 0.0027
Echinococcus granulosus hypothetical protein 0.0014 0.0011 0.0073
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0081 0.086
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0075 0.0149 0.156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.01
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0014 0.0147
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0014 0.0011 0.012
Trypanosoma brucei unspecified product 0.005 0.0093 0.4505
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Echinococcus granulosus hemicentin 1 0.0016 0.0016 0.0104
Schistosoma mansoni hypothetical protein 0.0348 0.0765 0.4897
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0092 0.0188 0.1202
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0132 0.0843
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0015 0.0409
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0016 0.0171
Brugia malayi Bromodomain containing protein 0.0016 0.0016 0.0165
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.017 0.1089
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0003 0.0016
Echinococcus granulosus peregrin 0.0016 0.0016 0.01
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0003 0.0016
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0024 0.0155
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0126 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0093 0.4505
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0049 0.1001
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.6709
Schistosoma mansoni cpg binding protein 0.0032 0.0052 0.0335
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0439
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0014 0.0089
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0089
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0049 0.0037
Mycobacterium tuberculosis Probable reductase 0.0203 0.0436 0.0426
Loa Loa (eye worm) zinc carboxypeptidase 0.0013 0.0008 0.0089
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0104
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0034 0.0055 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0171
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0001 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0028 0.1089
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0135 0.1427
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0135 0.0864
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Toxoplasma gondii aldose reductase, putative 0.0014 0.0011 0.05
Brugia malayi PXA domain containing protein 0.002 0.0024 0.0257
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0135 0.6709
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0087 0.0917
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0092 0.0188 0.1202
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0033 0.1174
Toxoplasma gondii PHD-finger domain-containing protein 0.0016 0.0016 0.0696
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0049 0.0516
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0135 0.0864
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0049 0.0654
Echinococcus granulosus neuroglian 0.0016 0.0016 0.0104
Echinococcus granulosus PHD finger protein rhinoceros 0.0016 0.0016 0.01
Schistosoma mansoni jumonji/arid domain-containing protein 0.0021 0.0027 0.0174
Echinococcus granulosus dna polymerase eta 0.0064 0.0124 0.0797
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0049 0.2201
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.005 0.0093 0.0594
Brugia malayi Phosphoglycerate kinase 0.0034 0.0057 0.0604
Echinococcus multilocularis hemicentin 1 0.0016 0.0016 0.0104
Echinococcus granulosus Ankyrin 0.0015 0.0014 0.0091
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0016 0.0016 0.0104
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0035 0.0365
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0013 0.0008 0.0089
Loa Loa (eye worm) zinc carboxypeptidase 0.0013 0.0008 0.0089
Brugia malayi CXXC zinc finger family protein 0.0031 0.0048 0.0512
Echinococcus multilocularis aldo keto reductase 0.0014 0.0011 0.0073
Brugia malayi Death domain containing protein 0.0015 0.0014 0.0147
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Plasmodium falciparum glutathione reductase 0.0031 0.0049 0.2227
Echinococcus granulosus netrin receptor unc 5 0.0024 0.0035 0.0221
Schistosoma mansoni netrin receptor unc5 0.0024 0.0035 0.0221
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0028 0.1089
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Schistosoma mansoni nephrin 0.0016 0.0016 0.0104
Trichomonas vaginalis aldo-keto reductase, putative 0.0014 0.0011 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0003 0.0027
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0092 0.0188 0.8636
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0003 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0003 0.0027
Loa Loa (eye worm) RNA binding protein 0.0068 0.0132 0.1392
Trypanosoma brucei phosphoglycerate kinase 0.0094 0.0191 0.9647
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0014 0.0011 0.0073
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0049 0.2201
Echinococcus granulosus lysine specific demethylase 5A 0.0021 0.0027 0.0174
Plasmodium falciparum glutathione reductase 0.0089 0.018 0.827
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Onchocerca volvulus 0.0014 0.0011 0.0094
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0013 0.0008 0.0027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.003 0.0321
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0016 0.0731
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0024 0.0155
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0075 0.0149 0.0953
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0081 0.3896
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0135 0.0864
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0016 0.0503
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0016 0.0105
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0649 1
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Loa Loa (eye worm) zinc carboxypeptidase 0.0013 0.0008 0.0089
Loa Loa (eye worm) oxidoreductase 0.0014 0.0011 0.012
Trypanosoma brucei prostaglandin f synthase 0.0014 0.0011 0.0241
Brugia malayi Phosphoglycerate kinase 0.0094 0.0191 0.2021
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0307 0.0296
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0225 0.0487 0.0485
Leishmania major trypanothione reductase 0.0089 0.018 0.9055
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0033 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0014 0.0604
Schistosoma mansoni peptidase 0.0013 0.0008 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0084 0.0539
Schistosoma mansoni axis inhibition protein axin 0.002 0.0024 0.0155
Toxoplasma gondii zinc carboxypeptidase, putative 0.0013 0.0008 0.0366
Loa Loa (eye worm) glutathione reductase 0.0089 0.018 0.1901
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0092 0.0188 0.1202
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0096 0.1017
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0225 0.0487 0.0477
Echinococcus granulosus roundabout 2 0.0016 0.0016 0.0104
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0092 0.0188 0.1985
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0024 0.0033 0.0022
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0033 0.0022
Schistosoma mansoni aldo-keto reductase 0.0014 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0059 0.0626
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0093 0.4505
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0059 0.0626
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0094 0.0191 0.9647
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0034 0.0057 0.2633
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0024 0.0257
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0016 0.0015 0.0648
Schistosoma mansoni thyroid hormone receptor 0.001 0.0003 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0093 0.4505
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0307 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0024 0.0272
Treponema pallidum NADH oxidase 0.0031 0.0049 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0003 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0104
Brugia malayi Zinc carboxypeptidase family protein 0.0013 0.0008 0.0089
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0016 0.0105
Loa Loa (eye worm) TK/ROR protein kinase 0.001 0.0001 0.0014
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0014 0.0011 0.0073
Schistosoma mansoni lamin 0.0029 0.0044 0.0283
Trypanosoma brucei unspecified product 0.0035 0.0058 0.2662
Echinococcus granulosus jumonji domain containing protein 0.0022 0.003 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0093 0.4505
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0069 0.0135 0.6709
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0024 0.0155
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0049 0.0037
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0135 0.1994
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0132 0.0843
Echinococcus granulosus integrin alpha 3 0.0013 0.0009 0.0059
Brugia malayi jmjC domain containing protein 0.0021 0.0027 0.0287
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0093 0.1339
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0024 0.0257
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0033 0.1498
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0093 0.0082
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0049 0.2201
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0024 0.0257
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0028 0.1089
Echinococcus multilocularis peroxidasin 0.0016 0.0016 0.0104

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.68 Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) ChEMBL. 10956210
IC50 (binding) = 2.1 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). ChEMBL. 9651163
IC50 (binding) = 2.1 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). ChEMBL. 9651163
IC50 (binding) = 49.9 uM Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). ChEMBL. 9651163
IC50 (binding) = 49.9 uM Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). ChEMBL. 9651163
IC50 (binding) = 66.6 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) ChEMBL. 9651163
IC50 (binding) = 66.6 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) ChEMBL. 9651163
IC50 (binding) > 100 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). ChEMBL. 9651163
IC50 (binding) > 100 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor ChEMBL. 9651163
IC50 (binding) > 100 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). ChEMBL. 9651163
IC50 (binding) > 100 uM Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor ChEMBL. 9651163
IC50 (binding) = 100 uM Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cells ChEMBL. 20117004
Log IC50 (binding) = 5.68 Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) ChEMBL. 10956210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.