Detailed information for compound 1476564

Basic information

Technical information
  • TDR Targets ID: 1476564
  • Name: (6S,7R)-7-[[(2S)-2-[(4-ethyl-2,3-dioxopiperaz ine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acet yl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylm ethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2- ene-2-carboxylic acid
  • MW: 645.667 | Formula: C25H27N9O8S2
  • H donors: 4 H acceptors: 11 LogP: 0.02 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCN1CCN(C(=O)C1=O)C(=O)N[C@@H](c1ccc(cc1)O)C(=O)N[C@@H]1C(=O)N2[C@H]1SCC(=C2C(=O)O)CSc1nnnn1C
  • InChi: 1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16+,22-/m0/s1
  • InChiKey: GCFBRXLSHGKWDP-DMPWYTOCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6S,7R)-7-[[(2S)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6S,7R)-7-[[(2S)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)-oxomethyl]amino]-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6S,7R)-7-[[(2S)-2-[(4-ethyl-2,3-diketo-piperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-8-keto-3-[[(1-methyltetrazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6S,7R)-7-[[(2S)-2-[(4-ethyl-2,3-dioxo-piperazin-1-yl)carbonylamino]-2-(4-hydroxyphenyl)ethanoyl]amino]-3-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0663 0.1209
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Echinococcus granulosus dihydrofolate reductase 0.0043 0.012 0.0157
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0297 0.0387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.005 0.0091
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0181 0.0235
Treponema pallidum sodium- and chloride- dependent transporter 0.0898 0.5482 1
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0224 0.044
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0567
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0526
Echinococcus multilocularis 0.0063 0.025 0.025
Brugia malayi P38 map kinase family protein 2 0.0124 0.063 0.115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0181 0.0329
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0224 0.0408
Loa Loa (eye worm) RNA binding protein 0.0129 0.0663 0.1209
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0181 0.0277
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.005 0.0091
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0035 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.005 0.0091
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0265 0.301
Onchocerca volvulus Alhambra homolog 0.0066 0.0265 0.047
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.015 0.0791 0.1213
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0567 0.1116
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Brugia malayi Bromodomain containing protein 0.004 0.0105 0.0192
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Loa Loa (eye worm) hypothetical protein 0.0102 0.0495 0.0903
Loa Loa (eye worm) hypothetical protein 0.01 0.0483 0.0882
Toxoplasma gondii hypothetical protein 0.0152 0.0809 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Brugia malayi nuclear hormone receptor 0.0052 0.0181 0.0329
Mycobacterium ulcerans beta-lactamase 0.0071 0.0297 0.0543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0026 0.0041
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0834 0.5085 1
Echinococcus granulosus muscleblind protein 0.0145 0.0763 0.0992
Schistosoma mansoni amine oxidase 0.0063 0.025 0.0384
Echinococcus granulosus tar DNA binding protein 0.0129 0.0663 0.0861
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0181 0.0235
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0181 0.0181
Brugia malayi PHD-finger family protein 0.0028 0.0028 0.005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0008 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.0703 0.1283
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0008 0.0012
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.005 0.0065
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Brugia malayi Dihydrofolate reductase 0.0043 0.012 0.022
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Brugia malayi nuclear receptor NHR-88 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0102 0.0495 0.0903
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Brugia malayi hypothetical protein 0.0025 0.0012 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0198 0.256
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0012 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0031 0.0061
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Mycobacterium leprae Probable lipase LipE 0.0071 0.0297 0.2948
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.005 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0181 0.0181
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0224 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.005 0.0091
Loa Loa (eye worm) carboxylesterase 0.0025 0.0012 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.01 0.048 0.0943
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0152 0.0809 0.1052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0375 0.0574
Loa Loa (eye worm) DR-78 0.0025 0.0008 0.0015
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0025 0.0012 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0042 0.0116 0.0212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0181 0.0235
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0297 0.0585
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0088
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.063 0.063
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0297 0.0585
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0056 0.0085
Loa Loa (eye worm) Smad1 0.0025 0.0012 0.0022
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0038 0.0074
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0465 0.5581
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0181 0.0315
Mycobacterium ulcerans fatty-acid-CoA ligase 0.01 0.048 0.0875
Plasmodium falciparum transporter, putative 0.0152 0.0809 1
Onchocerca volvulus 0.0102 0.0495 0.089
Echinococcus granulosus nAChR subunit 0.0031 0.005 0.0065
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0181 0.0329
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0483 0.0741
Echinococcus multilocularis protein patched 0.0042 0.0116 0.0116
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.063 0.115
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0008 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Loa Loa (eye worm) hypothetical protein 0.0112 0.0559 0.102
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.012 0.099
Echinococcus granulosus smad 0.0025 0.0012 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0647 0.1272
Brugia malayi conserved hypotetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.026 0.0399
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0152 0.0809 0.1241
Plasmodium falciparum amino acid transporter, putative 0.0152 0.0809 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0181 0.0329
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0038 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0088
Echinococcus granulosus lysine specific histone demethylase 1A 0.0063 0.025 0.0325
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0567 0.1116
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0173 0.034
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.012 0.022
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.063 0.063
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Onchocerca volvulus 0.0031 0.005 0.0077
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Echinococcus granulosus para nitrobenzyl esterase 0.0025 0.0012 0.0016
Plasmodium falciparum phd finger protein, putative 0.0066 0.0265 0.301
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0198 0.2149
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0038 0.0086
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Echinococcus granulosus lysine specific histone demethylase 1A 0.0063 0.025 0.0325
Schistosoma mansoni ap endonuclease 0.0059 0.0224 0.0343
Brugia malayi hypothetical protein 0.0055 0.0198 0.0361
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0116 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0181 0.0329
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0038 0.0182
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0181 0.0277
Echinococcus multilocularis acetylcholinesterase 0.015 0.0791 0.0791
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0038 0.0074
Brugia malayi hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni sodium/chloride dependent transporter 0.0898 0.5482 0.8406
Brugia malayi SWIRM domain containing protein 0.0063 0.025 0.0456
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0297 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Brugia malayi thymidylate synthase 0.0104 0.0507 0.0926
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0075 0.0321 0.0632
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.01 0.048 0.0943
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2067 1
Plasmodium vivax SET domain protein, putative 0.0098 0.0465 0.5581
Schistosoma mansoni hypothetical protein 0.0411 0.243 0.3726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0278 0.1597 0.2913
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0012 0.0012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0465 0.0465
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2688 0.5286
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.063 0.082
Echinococcus multilocularis geminin 0.1064 0.6521 0.6521
Loa Loa (eye worm) hypothetical protein 0.0055 0.0198 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0181 0.0329
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0026 0.0026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0181 0.0329
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0173 0.1821
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0022
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0063 0.025 0.2817
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0181 0.0329
Plasmodium vivax hypothetical protein, conserved 0.0063 0.025 0.2817
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0116 0.0151
Brugia malayi tailless protein 0.0025 0.0008 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.0153 0.0812 0.1245
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.053 0.0967
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0038 0.0069
Mycobacterium tuberculosis Conserved protein 0.0071 0.0297 0.0585
Plasmodium falciparum protoporphyrinogen oxidase 0.0063 0.025 0.2817
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0181 0.0181
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0152 0.0809 0.1476
Onchocerca volvulus Putative nachr subunit 0.0031 0.005 0.0077
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.005 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0167 0.0304
Brugia malayi Cation transporter family protein 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.0774 0.9547
Loa Loa (eye worm) ACC-1 protein 0.0031 0.005 0.0091
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.1597 0.2076
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0038 0.0074
Mycobacterium ulcerans lipase LipD 0.0071 0.0297 0.0543
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0647 0.6815
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Brugia malayi follicle stimulating hormone receptor 0.0297 0.1713 0.3125
Brugia malayi hypothetical protein 0.0152 0.0809 0.1476
Schistosoma mansoni nuclear receptor 0.0025 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0106 0.0193
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.005 0.0091
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.005 0.005
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0181 0.0277
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0031 0.04
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0088
Schistosoma mansoni sodium/chloride dependent transporter 0.0152 0.0809 0.1241
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0012 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0181 0.0181
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.0507 0.0998
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0173 0.0173
Plasmodium vivax amine transporter, putative 0.0152 0.0809 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0035 0.0063
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Onchocerca volvulus 0.0898 0.5482 1
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0173 0.1821
Leishmania major hypothetical protein, conserved 0.0071 0.0297 0.3843
Schistosoma mansoni eyes absent homolog 0.0092 0.043 0.0659
Echinococcus multilocularis muscleblind protein 0.0145 0.0763 0.0763
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.005 0.0065
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0181 0.0329
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.148 0.2701
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0181 0.0235
Loa Loa (eye worm) hypothetical protein 0.0092 0.043 0.0784
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.009 0.0117
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.005 0.0065
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0647 0.1272
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0567 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0297 0.0543
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0124
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0008 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0008 0.0015
Onchocerca volvulus 0.01 0.0483 0.0868
Echinococcus multilocularis smad 0.0025 0.0012 0.0012
Onchocerca volvulus 0.0031 0.005 0.0077
Echinococcus granulosus carboxylesterase 5A 0.015 0.0791 0.1029
Schistosoma mansoni dihydrofolate reductase 0.0043 0.012 0.0185
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0008 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0224 0.0478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0316 0.0576
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0224 0.2888
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0181 0.0329
Echinococcus multilocularis neuroligin 0.0025 0.0012 0.0012
Echinococcus multilocularis acetylcholinesterase 0.015 0.0791 0.0791
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0038 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.01 0.048 0.0875
Loa Loa (eye worm) carboxylesterase 0.015 0.0791 0.1443
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0008 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0297 0.1713 0.3125
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0224 0.1082
Loa Loa (eye worm) carboxylesterase 0.0025 0.0012 0.0022
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0475 0.0729
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0008 0.0008
Trichomonas vaginalis set domain proteins, putative 0.0769 0.4678 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.0074
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0224 0.2888
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.015 0.0791 0.1443
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0224 0.0353
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0167 0.2153
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.0091
Schistosoma mansoni acetylcholinesterase 0.0025 0.0012 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0935 1
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 0.9547
Schistosoma mansoni coup transcription factor 0.0052 0.0181 0.0277
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0773 0.0773
Onchocerca volvulus 0.0029 0.0035 0.0049
Brugia malayi TAR-binding protein 0.0129 0.0663 0.1209
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0483 0.0882
Loa Loa (eye worm) beta-lactamase 0.0071 0.0297 0.0543
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0265 0.0484
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0297 0.0585
Brugia malayi nuclear receptor RXR 0.0028 0.0026 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.2177 0.3971
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Schistosoma mansoni patched 1 0.0042 0.0116 0.0179
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0173 0.0315
Plasmodium vivax acyl-CoA synthetase, putative 0.0075 0.0321 0.3732
Leishmania major 4-coumarate:coa ligase-like protein 0.01 0.048 0.6197
Brugia malayi nuclear receptor NHR-67 0.0025 0.0008 0.0015
Brugia malayi Cation transporter family protein 0.0031 0.005 0.0091
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0898 0.5481 1
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0181 0.0235
Leishmania major trypanothione reductase 0.005 0.0167 0.2153
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.0577 0.075
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0224 0.0408
Loa Loa (eye worm) hypothetical protein 0.0115 0.0577 0.1053
Echinococcus granulosus acetylcholinesterase 0.015 0.0791 0.1029
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0008 0.0008
Brugia malayi CHE-14 protein 0.0042 0.0116 0.0212
Onchocerca volvulus 0.0025 0.0012 0.0008
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Brugia malayi nuclear hormone receptor 0.0025 0.0008 0.0015
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0224 0.0291
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0466 0.0605
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Echinococcus granulosus cpg binding protein 0.0032 0.0058 0.0075
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Mycobacterium ulcerans monoamine oxidase 0.0063 0.025 0.0456
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0181 0.0277
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0233 0.0426
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0031 0.0056
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0898 0.5482 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.012 0.0237
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Echinococcus granulosus sodium and chloride dependent glycine 0.0152 0.0809 0.1052
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Brugia malayi hypothetical protein 0.005 0.0165 0.0301
Mycobacterium ulcerans thymidylate synthase 0.0104 0.0507 0.0926
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0297 0.3843
Brugia malayi Bromodomain containing protein 0.008 0.0356 0.065
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0288 0.0526
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0063 0.025 0.2817
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Toxoplasma gondii hypothetical protein 0.0152 0.0809 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.063 0.8144
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0008 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Echinococcus multilocularis sodium and chloride dependent glycine 0.0152 0.0809 0.0809
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Brugia malayi hypothetical protein 0.0063 0.025 0.0456
Brugia malayi beta-lactamase family protein 0.0071 0.0297 0.0543
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0038 0.0049
Schistosoma mansoni amine oxidase 0.0063 0.025 0.0384
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.009 0.009
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Echinococcus granulosus expressed conserved protein 0.0092 0.0429 0.0557
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0234 0.2615
Brugia malayi dihydrofolate reductase family protein 0.0043 0.012 0.022
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0763 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0031 0.0056
Loa Loa (eye worm) ACC-1 protein 0.0031 0.005 0.0091
Echinococcus multilocularis neuropeptide s receptor 0.0556 0.3338 0.3338
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0069
Echinococcus granulosus PHD finger protein rhinoceros 0.0066 0.0265 0.0345
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0026 0.0034
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Onchocerca volvulus 0.0071 0.0297 0.0529
Schistosoma mansoni hypothetical protein 0.0066 0.0265 0.0407
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0066 0.0265 0.0407
Echinococcus multilocularis cpg binding protein 0.0032 0.0058 0.0058
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Brugia malayi beta-lactamase 0.0071 0.0297 0.0543
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Echinococcus multilocularis para nitrobenzyl esterase 0.0025 0.0012 0.0012
Brugia malayi nuclear receptor NHR-88 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Possible oxidoreductase 0.0063 0.025 0.0492
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0008 0.0012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.0577 0.0577
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0063 0.025 0.2426
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0008 0.0015
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0075 0.0321 0.3732
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0165 0.0352
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.005 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0008 0.0008
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0008 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0556 0.3338 0.4341
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0063 0.025 0.2817
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0198 0.2149
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.005 0.0065
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0773 0.1186
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0038 0.0086
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0647 0.1272
Plasmodium falciparum glutathione reductase 0.005 0.0167 0.1744
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0297 0.2948
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0167 0.0328
Chlamydia trachomatis protoporphyrinogen oxidase 0.0063 0.025 0.2817
Onchocerca volvulus 0.01 0.048 0.0862
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0663 0.0663
Onchocerca volvulus 0.0071 0.0297 0.0529
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0173 0.2231
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.01 0.048 0.0875
Onchocerca volvulus 0.0063 0.025 0.0442
Toxoplasma gondii ABC1 family protein 0.0071 0.0297 0.3424
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.063 0.063
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0063 0.025 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0663 0.1209
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0008 0.001
Schistosoma mansoni ap endonuclease 0.0059 0.0224 0.0343
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.048 0.2321
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0224 0.2475
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.012 0.022
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0063 0.025 0.2817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Onchocerca volvulus 0.0025 0.0012 0.0008
Mycobacterium tuberculosis Carboxylesterase LipT 0.0025 0.0012 0.0024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Brugia malayi nuclear receptor RXR 0.0025 0.0008 0.0015
Trichomonas vaginalis spcc417.12 protein, putative 0.0025 0.0012 0.0026
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0167 0.0167
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0012 0.0016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0375 0.0683
Onchocerca volvulus 0.0031 0.005 0.0077
Mycobacterium ulcerans dehydrogenase 0.0063 0.025 0.0456
Echinococcus multilocularis PHD finger protein rhinoceros 0.0066 0.0265 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0352 0.0352
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0181 0.0315
Echinococcus multilocularis jumonji domain containing protein 0.0091 0.0426 0.0426
Echinococcus granulosus neuroligin 0.0025 0.0012 0.0016
Brugia malayi Cation transporter family protein 0.0102 0.0495 0.0903
Loa Loa (eye worm) hypothetical protein 0.0088 0.0405 0.0738
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0012 0.0024
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0483 0.0628
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0173 0.0265
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0224 0.2475
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0297 0.0585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0979 0.2092
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Onchocerca volvulus 0.0029 0.0038 0.0054
Onchocerca volvulus 0.0052 0.0181 0.0315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0465 0.0713
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Loa Loa (eye worm) hypothetical protein 0.0428 0.254 0.4634
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0259 0.0472
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0152 0.0809 0.1052
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0038 0.0069
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0165 0.0324
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.243 0.243
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0152 0.0809 1
Echinococcus multilocularis thymidylate synthase 0.0104 0.0507 0.0507
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0152 0.0809 0.0809
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0152 0.0809 0.1052
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.005 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0173 0.1821
Brugia malayi MH2 domain containing protein 0.037 0.2177 0.3971
Mycobacterium tuberculosis Probable reductase 0.0114 0.0567 0.1116
Echinococcus granulosus jumonji domain containing protein 0.0091 0.0426 0.0554
Onchocerca volvulus 0.0102 0.0495 0.089
Brugia malayi steroid hormone receptor 0.0052 0.0181 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Echinococcus multilocularis expressed conserved protein 0.0092 0.0429 0.0429
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0038 0.0069
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Echinococcus granulosus dnaJ subfamily B 0.0411 0.243 0.316
Echinococcus granulosus sodium and chloride dependent glycine 0.0152 0.0809 0.1052
Brugia malayi Bromodomain containing protein 0.0068 0.0281 0.0512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0224 0.1082
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Onchocerca volvulus 0.0025 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0898 0.5482 1
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0921 0.1668
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0935 0.1706
Echinococcus granulosus BC026374 protein S09 family 0.0025 0.0012 0.0016
Brugia malayi Thioredoxin reductase 0.005 0.0167 0.0304
Loa Loa (eye worm) hypothetical protein 0.0145 0.0763 0.1391
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.2177 0.3971
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Schistosoma mansoni hypothetical protein 0.0147 0.0773 0.1186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0567 0.5934
Loa Loa (eye worm) LGC-31 protein 0.0031 0.005 0.0091
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0773 0.1006
Brugia malayi MH2 domain containing protein 0.0025 0.0012 0.0022
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0483 0.0483
Mycobacterium ulcerans carboxylesterase, LipT 0.0025 0.0012 0.0022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0297 0.0543
Leishmania major hypothetical protein, conserved 0.0055 0.0198 0.256
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0181 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0009 0.0009
Loa Loa (eye worm) norepinephrine transporter 0.0898 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.053 0.0967
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0048
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0038 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.01 0.048 0.0875
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0181 0.0181
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Schistosoma mansoni cpg binding protein 0.0032 0.0058 0.0088
Brugia malayi Pre-SET motif family protein 0.0676 0.4093 0.7466
Loa Loa (eye worm) hypothetical protein 0.0074 0.0316 0.0576
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0224 0.0408
Echinococcus granulosus Smad4 0.0025 0.0012 0.0016
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.005 0.0091
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0152 0.0809 0.1052
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0173 0.2231
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0567 0.1116
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0466 0.2253
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Onchocerca volvulus 0.0102 0.0495 0.089
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0008 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0181 0.0329
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0466 0.0849
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0038 0.0069
Echinococcus multilocularis Smad4 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0167 0.1744
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0181 0.0277
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5078 0.7787
Echinococcus multilocularis peregrin 0.0068 0.0281 0.0281
Brugia malayi Carboxylesterase family protein 0.015 0.0791 0.1443
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0288 0.0288
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.0507 0.5272
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Schistosoma mansoni hypothetical protein 0.0074 0.0316 0.0485
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0065 0.0261 0.2959
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0173 0.0315
Echinococcus granulosus Solute carrier family 22 5 0.125 0.7691 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0979 0.2092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0181 0.0277
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0663 0.1209
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0063 0.025 0.0456
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Brugia malayi Smad1 0.0025 0.0012 0.0022
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0008 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Brugia malayi hypothetical protein 0.0035 0.0076 0.0139
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0288 0.0375
Brugia malayi PHD-finger family protein 0.0066 0.0265 0.0484
Schistosoma mansoni Smad4 0.0025 0.0012 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0068 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.1597 0.2449
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0265 0.301
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.0121 0.0221
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.012 0.115
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Schistosoma mansoni smad 0.0025 0.0012 0.0019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0008 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Echinococcus multilocularis sodium and chloride dependent glycine 0.0152 0.0809 0.0809
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Onchocerca volvulus 0.0152 0.0809 0.1464
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0809 1
Echinococcus granulosus neuropeptide s receptor 0.0556 0.3338 0.4341
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0173 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Brugia malayi Carboxylesterase family protein 0.0025 0.0012 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0567 0.1116
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0181 0.0329
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0181 0.0277
Loa Loa (eye worm) glutathione reductase 0.005 0.0167 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0008 0.0008
Giardia lamblia PHD finger protein 15 0.0066 0.0265 0.1283
Entamoeba histolytica hypothetical protein 0.0028 0.0031 0.015
Brugia malayi MH1 domain containing protein 0.0025 0.0012 0.0022
Echinococcus granulosus peregrin 0.0068 0.0281 0.0365
Loa Loa (eye worm) hypothetical protein 0.0098 0.0466 0.0849
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.0465 0.0713
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0484
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.005 0.005
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Mycobacterium ulcerans hypothetical protein 0.0071 0.0297 0.0543
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0071 0.0297 0.0543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0181 0.0235
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Schistosoma mansoni gliotactin 0.0025 0.0012 0.0019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0173 0.1821
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0038 0.0069
Brugia malayi isocitrate dehydrogenase 0.0051 0.0173 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0181 0.0277
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0181 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.053 0.0967
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0026 0.0041
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0092 0.043 0.0784
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0025 0.0012 0.0024
Echinococcus multilocularis BC026374 protein (S09 family) 0.0025 0.0012 0.0012
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.063 0.082
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0165 0.2129
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.032
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0012 0.0022
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0152 0.0809 0.1241
Brugia malayi PHD-finger family protein 0.0025 0.0011 0.002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Onchocerca volvulus 0.0071 0.0297 0.0529
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0297 0.3424
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0297 0.0297
Brugia malayi hypothetical protein 0.0092 0.043 0.0784
Schistosoma mansoni hypothetical protein 0.004 0.0107 0.0164
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.005 0.005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.048 0.4964
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0181 0.0235
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0031 0.04
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0152 0.0809 0.1241
Schistosoma mansoni smad1 5 8 and 0.0025 0.0012 0.0019
Echinococcus multilocularis serotonin transporter 0.0898 0.5482 0.5482
Entamoeba histolytica acyl-coA synthetase, putative 0.01 0.048 0.2321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2067 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0181 0.0329
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0224 0.0224
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0898 0.5481 1
Onchocerca volvulus 0.0029 0.0038 0.0054
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.005 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.025 0.0492
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Brugia malayi hypothetical protein 0.0028 0.0026 0.0048
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0038 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0297 0.0456
Brugia malayi RNA binding protein 0.0129 0.0663 0.1209
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.053 0.0967
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Echinococcus granulosus thymidylate synthase 0.0104 0.0507 0.066
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Brugia malayi jmjC domain containing protein 0.0083 0.0375 0.0683
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0181 0.0235
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.005 0.0065
Brugia malayi Pre-SET motif family protein 0.0098 0.0465 0.0849
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.01 0.048 0.2321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2067 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.005 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0296 0.0582
Schistosoma mansoni hypothetical protein 0.1064 0.6521 1
Echinococcus granulosus GPCR family 2 0.0034 0.0068 0.0088
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0215 0.1201 0.1201
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0181 0.0329
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0063 0.025 0.0384
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.063 0.8144
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0181 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0297 0.3843
Loa Loa (eye worm) hypothetical protein 0.015 0.0791 0.1443
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.005 0.0091
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.0507 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0116 0.0249
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Loa Loa (eye worm) hypothetical protein 0.0063 0.025 0.0456
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0224 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0577 0.0885
Entamoeba histolytica hypothetical protein 0.0147 0.0773 0.3742
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0288 0.0526
Mycobacterium ulcerans hypothetical protein 0.01 0.048 0.0875
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0556 0.3338 0.3338
Brugia malayi glutathione reductase 0.005 0.0167 0.0304
Loa Loa (eye worm) oxidoreductase 0.0029 0.0038 0.0069
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0486
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2067 0.3735
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0038 0.0074
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0288 0.0442
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.0029 0.0035 0.0053
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0198 0.256
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Toxoplasma gondii thioredoxin reductase 0.005 0.0167 0.1744
Trypanosoma cruzi UDP-galactopyranose mutase 0.0063 0.025 0.3232
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.148 0.3165
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Brugia malayi ecdysone receptor 0.0025 0.0008 0.0015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0676 0.4093 0.7466
Onchocerca volvulus 0.0034 0.0067 0.0108
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0439 0.0571
Onchocerca volvulus 0.0098 0.0465 0.0835
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0025 0.0012 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0068 0.0124
Echinococcus multilocularis carboxylesterase 5A 0.015 0.0791 0.0791
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0078 0.0143
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0181 0.0181
Onchocerca volvulus 0.0025 0.0012 0.0008
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0063 0.025 0.025
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0181 0.0329
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.005 0.005
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.005 0.0065
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0038 0.0069
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.0069
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0181 0.0329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0577 0.0885
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0181 0.0329
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0025 0.0012 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0898 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0116 0.0151
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0297 0.0636
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0297 0.0585
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0181 0.0277
Trypanosoma cruzi UDP-galactopyranose mutase 0.0063 0.025 0.3232
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Trypanosoma brucei trypanothione reductase 0.005 0.0167 0.2153
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.002
Schistosoma mansoni bromodomain containing protein 0.0068 0.0279 0.0428
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0297 0.0636
Loa Loa (eye worm) hypothetical protein 0.0052 0.0181 0.0329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0278 0.1597 0.2913
Onchocerca volvulus 0.0152 0.0809 0.1464
Echinococcus granulosus lysine specific demethylase 5A 0.0083 0.0375 0.0487
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0224 0.2888
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.148 0.2701
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5078 0.5078
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0012 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0152 0.0809 0.1476
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Plasmodium falciparum thioredoxin reductase 0.005 0.0167 0.1744
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0728 0.0728
Onchocerca volvulus 0.0769 0.4678 0.8531
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.005 0.005
Leishmania major UDP-galactopyranose mutase 0.0063 0.025 0.3232
Loa Loa (eye worm) hypothetical protein 0.0428 0.254 0.4634
Echinococcus multilocularis nAChR subunit 0.0031 0.005 0.005
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0181 0.0315
Onchocerca volvulus 0.0025 0.0012 0.0008
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0013
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Echinococcus multilocularis protoporphyrinogen oxidase 0.0063 0.025 0.025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.1597 0.2076
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Trichomonas vaginalis esterase, putative 0.0071 0.0297 0.0636
Brugia malayi beta-lactamase family protein 0.0071 0.0297 0.0543
Plasmodium vivax hypothetical protein, conserved 0.0063 0.025 0.2817
Onchocerca volvulus 0.0029 0.0038 0.0054
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0116 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0068 0.0124
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.005 0.0091
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0152 0.0809 0.0809
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0898 0.5482 0.8406
Plasmodium vivax glutathione reductase, putative 0.005 0.0167 0.1744
Brugia malayi hypothetical protein 0.0025 0.0008 0.0015
Loa Loa (eye worm) thymidylate synthase 0.0104 0.0507 0.0926
Schistosoma mansoni hypothetical protein 0.1064 0.6521 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0012 0.0016
Toxoplasma gondii exonuclease III APE 0.0059 0.0224 0.2475
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0074 0.0318 0.058
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0181 0.0329
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0008 0.0012
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 0.9547
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0025 0.0012 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0181 0.0277
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0265 0.301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0181 0.0329
Loa Loa (eye worm) hypothetical protein 0.0145 0.0763 0.1391
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0297 0.0636
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0008 0.0015
Mycobacterium ulcerans oxidoreductase 0.0063 0.025 0.0456
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0224 0.2888
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.0774 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0181 0.0181
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0167 0.0217
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0008 0.0008
Schistosoma mansoni nuclear receptor 0.0025 0.0008 0.0012
Loa Loa (eye worm) acetylcholinesterase 1 0.015 0.0791 0.1443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.1597 0.1597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.1597 0.1597
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0173 0.2231
Schistosoma mansoni nAChR subunit 0.0031 0.005 0.0077
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0008 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.005 0.0091
Brugia malayi hypothetical protein 0.0025 0.0008 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0026 0.0048
Brugia malayi ecdysteroid receptor 0.0052 0.0181 0.0329
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0008 0.0008
Brugia malayi Carboxylesterase family protein 0.015 0.0791 0.1443
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.005 0.005
Loa Loa (eye worm) serotonin transporter b 0.0898 0.5482 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0181 0.0329
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0038 0.0086
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0288 0.3724
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0263
Brugia malayi Cytochrome P450 family protein 0.0061 0.0233 0.0426
Onchocerca volvulus 0.0104 0.0507 0.0912
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0256 0.0333
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.005 0.0077
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0015
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0198 0.256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0181 0.0329
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.005 0.005
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0935 0.1838
Toxoplasma gondii histone lysine-specific demethylase 0.0063 0.025 0.2817
Echinococcus granulosus geminin 0.1064 0.6521 0.848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.01 0.048 0.4964
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0297 0.0585
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0152 0.0809 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Schistosoma mansoni sodium-dependent amino acid transporter 0.0152 0.0809 0.1241
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0038 0.0086
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0038 0.0486
Echinococcus multilocularis GPCR, family 2 0.0034 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0181 0.0181
Echinococcus multilocularis protein dispatched 1 0.0048 0.0154 0.0154
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0152 0.0809 0.1476
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0068 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.01 0.048 0.0875
Schistosoma mansoni jumonji domain containing protein 0.0171 0.0924 0.1417
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Brugia malayi Muscleblind-like protein 0.0145 0.0763 0.1391
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.005 0.0091
Schistosoma mansoni neuroligin 3 (S09 family) 0.0025 0.0012 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0173 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Brugia malayi hypothetical protein 0.0147 0.0773 0.1411
Schistosoma mansoni jumonji/arid domain-containing protein 0.0083 0.0375 0.0574
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0663 0.1016
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0102 0.0495 0.0759
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.005 0.0065
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0102 0.0495 0.0759
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0009 0.0012
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0152 0.0809 0.0809
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0297 0.0543
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.063 0.063
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0297 0.3843
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0038 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2067 0.4418
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0091
Echinococcus granulosus acetylcholinesterase 0.015 0.0791 0.1029
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Brugia malayi amine oxidase, flavin-containing family protein 0.0063 0.025 0.0456
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0728 0.0947
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0008 0.0015
Onchocerca volvulus 0.0152 0.0809 0.1464
Loa Loa (eye worm) hypothetical protein 0.01 0.048 0.0875
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.0069
Plasmodium falciparum acyl-CoA synthetase 0.0075 0.0321 0.3732
Schistosoma mansoni zinc finger protein 0.0025 0.0008 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0297 0.0585
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0215 0.1201 0.1562
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0074
Echinococcus granulosus serotonin transporter 0.0898 0.5482 0.7128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0297 0.0543
Brugia malayi AMP-binding enzyme family protein 0.01 0.048 0.0875
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0012 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0921 0.1969
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5078 0.6603
Brugia malayi jmjC domain containing protein 0.0215 0.1201 0.2191
Schistosoma mansoni BC026374 protein (S09 family) 0.0025 0.0012 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0321 0.0586

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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