TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.388 | Formula: C19H20N4O
H donors: 3 H acceptors: 3 LogP: 3.3 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)c1nc(N[C@@H]2CNCC2)c2c(n1)cccc2)O
InChi: 1S/C19H20N4O/c1-12-6-7-17(24)15(10-12)19-22-16-5-3-2-4-14(16)18(23-19)21-13-8-9-20-11-13/h2-7,10,13,20,24H,8-9,11H2,1H3,(H,21,22,23)/t13-/m0/s1
InChiKey: BOWCJYLFFPRVBT-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	checkpoint kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	protein kinase	Get druggable targets OG5_128695	All targets in OG5_128695
Echinococcus granulosus	serine:threonine protein kinase Chk2	Get druggable targets OG5_128695	All targets in OG5_128695
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	Get druggable targets OG5_128695	All targets in OG5_128695
Echinococcus multilocularis	serine:threonine protein kinase Chk2	Get druggable targets OG5_128695	All targets in OG5_128695
Candida albicans	protein kinase	Get druggable targets OG5_128695	All targets in OG5_128695
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	Get druggable targets OG5_128695	All targets in OG5_128695
Schistosoma japonicum	ko:K06641 serine/threonine-protein kinase Chk2, putative	Get druggable targets OG5_128695	All targets in OG5_128695
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_128695	All targets in OG5_128695
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128695	All targets in OG5_128695
Candida albicans	kinase involved in DNA repair	Get druggable targets OG5_128695	All targets in OG5_128695
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_128695	All targets in OG5_128695
Candida albicans	kinase involved in DNA repair	Get druggable targets OG5_128695	All targets in OG5_128695

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0004	0.002	1
Echinococcus multilocularis	retinol dehydrogenase 13	0.0004	0.002	0.0055
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Leishmania major	hypothetical protein, conserved	0.0004	0.002	0.5
Loa Loa (eye worm)	dehydrogenase	0.0004	0.002	0.002
Brugia malayi	MH1 domain containing protein	0.0008	0.0389	0.0389
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0004	0.002	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0004	0.002	0.0055
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0004	0.002	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0004	0.002	0.5
Brugia malayi	MH1 domain containing protein	0.0004	0.0075	0.0075
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0004	0.002	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Giardia lamblia	Reductase, putative	0.0004	0.002	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0004	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0004	0.002	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0004	0.002	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.002	0.0055
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0004	0.002	0.002
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	Smad4	0.0008	0.0389	0.1049
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Leishmania major	dehydrogenase-like protein	0.0004	0.002	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.002	0.5
Echinococcus multilocularis	serine:threonine protein kinase Chk2	0.0046	0.3706	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.002	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Echinococcus multilocularis	smad	0.0008	0.0389	0.1049
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.002	0.0055
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0004	0.002	0.0055
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Brugia malayi	hypothetical protein	0.0004	0.002	0.002
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.002	0.0055
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0004	0.002	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Echinococcus multilocularis	oxidoreductase	0.0004	0.002	0.0055
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0004	0.002	0.002
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0004	0.002	0.5
Brugia malayi	MH2 domain containing protein	0.0008	0.0389	0.0389
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Echinococcus granulosus	hypothetical protein	0.0004	0.002	0.0055
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0004	0.002	0.5
Brugia malayi	MH2 domain containing protein	0.0008	0.0389	0.0389
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0004	0.002	0.0055
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Plasmodium vivax	steroid dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0004	0.002	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.3706	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Echinococcus granulosus	hypothetical protein	0.0004	0.002	0.0055
Echinococcus granulosus	oxidoreductase	0.0004	0.002	0.0055
Onchocerca volvulus		0.0004	0.002	1
Leishmania major	pteridine reductase 1	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0004	0.002	0.0055
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.002	0.5
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0389	0.1049
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.002	0.0055
Plasmodium falciparum	steroid dehydrogenase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	0.0046	0.3704	0.9996
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Loa Loa (eye worm)	dehydrogenase	0.0004	0.002	0.002
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Echinococcus granulosus	Smad4	0.0008	0.0389	0.1049
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	0.0046	0.3704	0.9996
Echinococcus granulosus	smad	0.0008	0.0389	0.1049
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Entamoeba histolytica	protein kinase, putative	0.0046	0.3706	1
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.002	0.0055
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	1	1
Entamoeba histolytica	protein kinase, putative	0.0046	0.3706	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0389	0.1049
Leishmania major	hypothetical protein, conserved	0.0004	0.002	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.002	0.0055
Echinococcus granulosus	serine:threonine protein kinase Chk2	0.0046	0.3706	1
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0004	0.002	0.0055
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0004	0.002	0.0055
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0004	0.002	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0004	0.002	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0004	0.002	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Onchocerca volvulus		0.0004	0.002	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0004	0.002	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0004	0.002	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Schistosoma mansoni	smad	0.0008	0.0389	0.1049
Toxoplasma gondii	carbonyl reductase 1, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.002	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0004	0.002	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	Smad1	0.0008	0.0389	0.0389
Onchocerca volvulus		0.0004	0.002	1
Leishmania major	oxidoreductase-like protein	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0004	0.002	0.0055
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.002	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.002	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.002	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0004	0.002	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.002	0.0055
Mycobacterium ulcerans	dehydrogenase	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0389	0.1049
Leishmania major	hypothetical protein, conserved	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0004	0.002	0.0055
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0389	0.1049
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.002	0.0055
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0389	0.1049
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0004	0.002	0.0055
Brugia malayi	hypothetical protein	0.0004	0.002	0.002
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0004	0.002	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.002	0.0055
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0389	0.0389
Leishmania major	short chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.002	0.0055
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	nuclear factor I	0.0004	0.0075	0.0075
Schistosoma mansoni	carbonyl reductase	0.0004	0.002	0.0055
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0004	0.002	0.0055
Leishmania major	hypothetical protein, conserved	0.0004	0.002	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.002	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.002	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0004	0.002	0.002
Mycobacterium ulcerans	oxidoreductase	0.0004	0.002	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0004	0.002	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0004	0.002	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.002	0.0055
Brugia malayi	dehydrogenases, short chain protein 9	0.0004	0.002	0.002
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.002	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0004	0.002	0.002
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0389	0.1049
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0004	0.002	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0004	0.002	0.002
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.002	0.0055
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0004	0.002	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.002	0.0055
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0075	0.0075
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0004	0.002	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0004	0.002	0.0055
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0389	0.1049
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.002	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0004	0.002	0.002
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Brugia malayi	MH1 domain containing protein	0.0008	0.0389	0.0389
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0004	0.002	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0004	0.002	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.002	0.0055
Leishmania major	short chain dehydrogenase, putative	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Brugia malayi	MH1 domain containing protein	0.0004	0.0075	0.0075
Echinococcus granulosus	steroid dehydrogenase	0.0004	0.002	0.0055
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.002	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.002	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0004	0.002	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.002	0.0055
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0004	0.002	0.002
Onchocerca volvulus		0.0004	0.002	1
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.002	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0004	0.002	0.0055
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.002	0.0055
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.002	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.002	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Giardia lamblia	Hypothetical protein	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0004	0.002	1
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.002
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.002	0.0055
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0004	0.002	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0004	0.002	0.5
Onchocerca volvulus		0.0004	0.002	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0004	0.002	0.002
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.002	0.0055
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.5
Brugia malayi	Smad1	0.0008	0.0389	0.0389
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.002	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.002	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.002	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0004	0.002	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.002	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.002	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.002	0.5
Brugia malayi	oxidoreductase	0.0004	0.002	0.002
Onchocerca volvulus		0.0004	0.002	1
Loa Loa (eye worm)	oxidoreductase	0.0004	0.002	0.002
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.002	0.5
Echinococcus multilocularis	Smad4	0.0008	0.0389	0.1049
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.002	0.0055
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0389	0.0389
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.002	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0389	0.1049
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.002	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0004	0.002	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of CHK1 by DELFIA assay	ChEMBL.	21186793
IC50 (binding)	= 0.092 uM	Inhibition of CHK2 by DELFIA assay	ChEMBL.	21186793
Inhibition (binding)		Inhibition of human ERG at 10 uM	ChEMBL.	21186793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1650107

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1491152