Detailed information for compound 1503324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 589.07 | Formula: C26H32ClF3N4O4S
  • H donors: 4 H acceptors: 4 LogP: 1.9 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCS[C@H]1C(=O)NCc1ccc(cc1)N[C@@H](C(=O)O)C(C)C.Cl
  • InChi: 1S/C26H31F3N4O4S.ClH/c1-14(2)23(26(36)37)32-18-5-3-15(4-6-18)13-31-24(35)25-33(7-8-38-25)22(34)11-17(30)9-16-10-20(28)21(29)12-19(16)27;/h3-6,10,12,14,17,23,25,32H,7-9,11,13,30H2,1-2H3,(H,31,35)(H,36,37);1H/t17-,23-,25+;/m1./s1
  • InChiKey: WGTQOPKMWHLPHY-OZWXPUTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References
Homo sapiens dipeptidyl-peptidase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase Get druggable targets OG5_129743 All targets in OG5_129743
Echinococcus multilocularis Dipeptidyl peptidase 9 Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma brucei serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Leishmania mexicana dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129743 All targets in OG5_129743
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) Get druggable targets OG5_129743 All targets in OG5_129743
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K08656 dipeptidyl-peptidase 9, putative Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania braziliensis dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania donovani serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129743 All targets in OG5_129743
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Leishmania infantum dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma brucei gambiense dipeptidyl-peptidase 8-like serine protease Get druggable targets OG5_129743 All targets in OG5_129743
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative Get druggable targets OG5_129743 All targets in OG5_129743
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus Dipeptidyl peptidase 9 Get druggable targets OG5_129743 All targets in OG5_129743
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sterol regulatory element binding protein 0.0137 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0311 0.3499 0.4762
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.005 0.0113
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0293 0.3279 1
Schistosoma mansoni phosphatidylserine receptor 0.0043 0.03 0.03
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0012 0.0012
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.005 0.0021
Onchocerca volvulus 0.0062 0.0523 0.094
Schistosoma mansoni SWI/SNF complex-related 0.0024 0.0077 0.0077
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0068 0.0592 0.4249
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.005 0.0244
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Echinococcus granulosus peroxidasin 0.0056 0.0452 0.0452
Brugia malayi prolyl oligopeptidase family protein 0.028 0.3121 0.4248
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.024 0.0281
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.005 0.0113
Loa Loa (eye worm) beta-lactamase 0.0035 0.0207 0.0282
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0908 0.1237
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0634 0.7347 0.7347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.0897 0.2676
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0035 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0012 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0686 0.9096
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.131 0.1783
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0283 0.1967
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.137 0.1825
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.024 0.1652
Brugia malayi nuclear receptor NHR-88 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0181 0.0247
Brugia malayi Bromodomain containing protein 0.0029 0.0127 0.0173
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.1728
Loa Loa (eye worm) hypothetical protein 0.0166 0.1766 0.2403
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.028 0.3121 0.3121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0634 0.7347 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.028 0.3121 0.5612
Schistosoma mansoni alpha-glucosidase 0.0136 0.1409 0.1409
Echinococcus granulosus peregrin 0.0029 0.0127 0.0127
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0068 0.0592 0.0761
Echinococcus granulosus lysine specific demethylase 5A 0.0165 0.1754 0.1754
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) prolyl oligopeptidase 0.028 0.3121 0.4248
Onchocerca volvulus 0.0335 0.3781 0.6798
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0452 0.0812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Echinococcus multilocularis RUN 0.0042 0.0283 0.0283
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0134 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0311 0.3499 0.4762
Loa Loa (eye worm) hypothetical protein 0.0249 0.2756 0.3751
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni cpg binding protein 0.006 0.0503 0.0503
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.005 0.0024
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.1197 0.1629
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0175 0.0175
Echinococcus multilocularis protein patched 0.0137 0.1423 0.1423
Toxoplasma gondii propionate-CoA ligase 0.0022 0.005 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0127 0.0813
Brugia malayi hypothetical protein 0.0108 0.1069 0.1454
Entamoeba histolytica hypothetical protein 0.0634 0.7347 0.9976
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Echinococcus granulosus geminin 0.0548 0.6321 0.6321
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0291 0.3257 0.3257
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0024 0.0077 0.0077
Onchocerca volvulus 0.0019 0.0017 0.0031
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Onchocerca volvulus Protein patched homolog 0.0019 0.0017 0.0031
Loa Loa (eye worm) glutaminase 2 0.0554 0.6399 0.871
Echinococcus multilocularis 0.0081 0.0749 0.0749
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.005 0.0068
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.3257 0.4406
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0207 0.0594
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0304
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0311 0.349 0.349
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.6926
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Brugia malayi steroid hormone receptor 0.0062 0.0523 0.0712
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0523 0.0712
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0635 0.7364 1
Entamoeba histolytica SWIRM domain protein 0.0024 0.0077 0.0057
Schistosoma mansoni dep domain containing protein 0.0019 0.0012 0.0012
Echinococcus granulosus microtubule associated protein 2 0.0705 0.8198 0.8198
Loa Loa (eye worm) blistered cuticle protein 3 0.0056 0.0449 0.0611
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Echinococcus multilocularis muscleblind protein 1 0.0166 0.1766 0.1766
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0311 0.349 0.4751
Mycobacterium leprae Probable lipase LipE 0.0035 0.0207 0.2246
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0181 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Brugia malayi N-terminal motif family protein 0.0385 0.4381 0.5964
Mycobacterium ulcerans hypothetical protein 0.0035 0.0207 0.0271
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0496 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Schistosoma mansoni hypothetical protein 0.0042 0.0283 0.0283
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.005 0.005
Onchocerca volvulus 0.006 0.0503 0.0904
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Trypanosoma brucei RNA helicase, putative 0.0248 0.2741 0.3701
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0249 0.2761 0.2761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0523 0.0712
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0291 0.3257 0.4406
Entamoeba histolytica hypothetical protein 0.0038 0.024 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.024 0.028
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0278
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.07 0.0952
Onchocerca volvulus 0.0022 0.0048 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Leishmania major hypothetical protein, conserved 0.0043 0.03 0.0821
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0043 0.03 0.03
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Echinococcus multilocularis phd:f box containing protein 0.0043 0.03 0.03
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.03 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni rab6-interacting 0.0042 0.0283 0.0283
Brugia malayi Patched related family protein 4 0.0019 0.0017 0.0023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0523 0.0523
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0755 0.0982
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi PHD-finger family protein 0.0029 0.0127 0.0173
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0207 0.0271
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0081 0.0749 0.5414
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0046 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Brugia malayi nuclear receptor RXR 0.0029 0.0134 0.0182
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0426 0.0579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0134 0.0134
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0181 0.0557
Brugia malayi isocitrate dehydrogenase 0.0068 0.0592 0.0805
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0207 0.0594
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.005 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0165 0.1754 0.2387
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.005 0.0068
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Echinococcus multilocularis dnaJ subfamily B 0.0856 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0235
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0426 0.0426
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0204 0.0278
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.005 0.0021
Onchocerca volvulus 0.0019 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0083 0.0775 0.1054
Echinococcus granulosus polyADP ribose glycohydrolase 0.0634 0.7347 0.7347
Entamoeba histolytica hypothetical protein 0.0094 0.0908 0.1192
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.005 0.0113
Schistosoma mansoni hypothetical protein 0.006 0.0496 0.0496
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.005 0.0113
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni zinc finger protein 0.0029 0.0134 0.0134
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0282 0.3154 0.4255
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1338 0.1822
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0634 0.7347 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0204 0.0231
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0035 0.0048
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) RNA binding protein 0.0128 0.131 0.1783
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0421 0.0572
Echinococcus multilocularis tumor protein p63 0.0354 0.4005 0.4005
Loa Loa (eye worm) hypothetical protein 0.0105 0.104 0.1416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0166 0.1766 0.2403
Giardia lamblia Kinase, PLK 0.0093 0.0897 0.2755
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.005 0.0047
Plasmodium vivax vivapain-2 0.0022 0.0048 0.023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0523 0.0712
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.0897 0.1221
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0107 0.106 0.1443
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0291 0.3257 0.4406
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0134 0.0134
Brugia malayi SWIRM domain containing protein 0.0335 0.3781 0.5147
Entamoeba histolytica hypothetical protein, conserved 0.0291 0.3257 0.4396
Echinococcus multilocularis slit 2 protein 0.0018 0.0003 0.0003
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.0897 0.1176
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0755 0.0982
Loa Loa (eye worm) hypothetical protein 0.0123 0.1253 0.1706
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0426 0.0426
Mycobacterium tuberculosis Probable peptidase 0.0033 0.0181 0.0515
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0139 0.1447 0.197
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Brugia malayi hypothetical protein 0.0019 0.0012 0.0016
Echinococcus granulosus slit 2 protein 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0134 0.0182
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0204 0.0204
Echinococcus multilocularis geminin 0.0548 0.6321 0.6321
Schistosoma mansoni hypothetical protein 0.0051 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0134 0.0134
Onchocerca volvulus 0.0022 0.005 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0081 0.0749 0.5414
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0523 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0235
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0856 1 1
Brugia malayi nuclear receptor NHR-67 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0523 0.094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0134 0.0134
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0426 0.0534
Onchocerca volvulus 0.0022 0.005 0.009
Toxoplasma gondii hypothetical protein 0.0019 0.0017 0.0023
Echinococcus multilocularis GPCR, family 2 0.0098 0.096 0.096
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.005 0.0021
Echinococcus granulosus muscleblind protein 0.0166 0.1766 0.1766
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0426 0.0426
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0261 0.0261
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0459 0.1363
Toxoplasma gondii ABC1 family protein 0.0035 0.0207 0.0282
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Onchocerca volvulus 0.0019 0.0017 0.0031
Giardia lamblia PHD finger protein 15 0.0029 0.0127 0.039
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0116 0.0158
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0207 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0068 0.0592 0.1771
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.07 0.07
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0283 0.1967
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Toxoplasma gondii NAC domain-containing protein 0.0038 0.024 0.0327
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Brugia malayi hypothetical protein 0.0484 0.5562 0.7571
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0134 0.024
Schistosoma mansoni hypothetical protein 0.0213 0.2324 0.2324
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.1197 0.1589
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0181 0.02
Onchocerca volvulus 0.0022 0.0048 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0523 0.094
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0081 0.0749 0.5414
Echinococcus granulosus cpg binding protein 0.0064 0.0544 0.0544
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0459 0.3264
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.004 0.0258 0.0304
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0207 0.0235
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.049 0.0667
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0068 0.0592 0.0592
Trypanosoma brucei oligopeptidase b 0.0033 0.0181 0.02
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.005 0.0113
Loa Loa (eye worm) fibroinase 0.0022 0.0048 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0523 0.0523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Entamoeba histolytica SWIRM domain protein 0.0024 0.0077 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0592 0.0805
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0134 0.0182
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0118 0.1197 0.1197
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0426 0.1212
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.024 0.0281
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0749 0.0977
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Onchocerca volvulus 0.0019 0.0017 0.0031
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0087
Brugia malayi jmjC domain containing protein 0.0165 0.1754 0.2387
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.096 0.096
Onchocerca volvulus 0.0042 0.0283 0.0509
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0208 0.2266 0.3051
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0282 0.3154 0.4293
Loa Loa (eye worm) hypothetical protein 0.0385 0.4381 0.5964
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0012 0.0012
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0127 0.0173
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0426 0.1212
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0048 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Echinococcus multilocularis peroxidasin 0.0056 0.0452 0.0452
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.0761
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0523 0.0712
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.028 0.3121 0.3121
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Schistosoma mansoni protein phosphatase 2C 0.0043 0.03 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0137 0.1423 0.1937
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0686 0.1023
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0311 0.3499 0.4762
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0127 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0749 0.5414
Schistosoma mansoni alpha-glucosidase 0.0136 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0024 0.0077 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0207 0.0207
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.005 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0523 0.0712
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0291 0.3257 0.4406
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.005 0.0024
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.0897 0.1613
Schistosoma mansoni nuclear receptor 0.0029 0.0134 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Leishmania major hypothetical protein, conserved 0.0133 0.137 0.4143
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0048 0.0065
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0181 0.0247
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0012 0.0016
Toxoplasma gondii cathepsin CPL 0.0022 0.0048 0.0065
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0385
Echinococcus granulosus sterol regulatory element binding protein 0.0137 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0048 0.023
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0127 0.0173
Schistosoma mansoni hypothetical protein 0.0548 0.6321 0.6321
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0046 0.034 0.034
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Echinococcus granulosus Protein patched homolog 1 0.0137 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0204 0.0204
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.005 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0523 0.0712
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0181 0.0326
Trypanosoma brucei PAB1-binding protein , putative 0.0133 0.137 0.1825
Echinococcus granulosus tar DNA binding protein 0.0128 0.131 0.131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0523 0.0712
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0523 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0523 0.0712
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.096 0.1307
Loa Loa (eye worm) cysteine protease 0.0022 0.0048 0.0065
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.004 0.0258 0.0305
Echinococcus granulosus jumonji domain containing 1A 0.0043 0.03 0.03
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0048 0.0041
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0523 0.0712
Onchocerca volvulus 0.0026 0.0098 0.0177
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0134 0.1382 0.1881
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0204 0.0231
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.005 0.0024
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0068
Brugia malayi hypothetical protein 0.0056 0.0449 0.0611
Brugia malayi Poly 0.0634 0.7347 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0291 0.3257 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0216 0.0247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Onchocerca volvulus 0.0056 0.0449 0.0807
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0523 0.0523
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Onchocerca volvulus Chorion peroxidase homolog 0.0056 0.0449 0.0807
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0008 0.001
Onchocerca volvulus Protein patched homolog 0.0019 0.0017 0.0031
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0012 0.0016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0523 0.0712
Onchocerca volvulus Peroxidasin homolog 0.0056 0.0449 0.0807
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0523 0.0523
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0207 0.0594
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0068 0.0592 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0523 0.0712
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0127 0.0127
Onchocerca volvulus Peroxidase homolog 0.0056 0.0449 0.0807
Schistosoma mansoni jumonji domain containing protein 0.0043 0.03 0.03
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.005 0.0068
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0104
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0035 0.5
Echinococcus granulosus expressed conserved protein 0.03 0.3369 0.3369
Echinococcus multilocularis Niemann Pick C1 protein 0.0457 0.5237 0.5237
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0118 0.1197 0.1197
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.8198 0.8198
Loa Loa (eye worm) hypothetical protein 0.0075 0.0686 0.0934
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.096 0.096
Echinococcus multilocularis Niemann Pick C1 protein 0.032 0.36 0.36
Mycobacterium ulcerans monoamine oxidase 0.0081 0.0749 0.1123
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.3051
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0426 0.0579
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0134 0.0134
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0686 0.1023
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Echinococcus granulosus lysine specific histone demethylase 1A 0.0311 0.349 0.349
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0523 0.0523
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0134 0.0134
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0048 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Trypanosoma brucei glucosidase, putative 0.0035 0.0204 0.0231
Toxoplasma gondii exonuclease III APE 0.0021 0.0035 0.0048
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0426 0.0426
Onchocerca volvulus 0.0042 0.0283 0.0509
Giardia lamblia hypothetical protein 0.0024 0.0077 0.0236
Echinococcus multilocularis expressed conserved protein 0.03 0.3369 0.3369
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0181 0.1215
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0686 0.206
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0411 0.0514
Onchocerca volvulus 0.0029 0.0134 0.024
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0012 0.0012
Brugia malayi nuclear receptor RXR 0.0033 0.0175 0.0239
Leishmania major hypothetical protein, conserved 0.0035 0.0207 0.0534
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni hypothetical protein 0.0029 0.0127 0.0127
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Echinococcus granulosus phd:f box containing protein 0.0043 0.03 0.03
Echinococcus multilocularis lysine specific demethylase 6a 0.0043 0.03 0.03
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.0908 0.1192
Brugia malayi Isocitrate dehydrogenase 0.0068 0.0592 0.0805
Echinococcus multilocularis JmjC domain containing protein 4 0.0043 0.03 0.03
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0635 0.7364 1
Onchocerca volvulus 0.0022 0.0048 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0012 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0043 0.03 0.0408
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0403 0.0403
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0118 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0213 0.2324 0.3163
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Schistosoma mansoni coup transcription factor 0.0062 0.0523 0.0523
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0395 0.0493
Entamoeba histolytica hypothetical protein 0.0024 0.0077 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0615
Toxoplasma gondii isocitrate dehydrogenase 0.0068 0.0592 0.0805
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0207 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0897 0.1179
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.005 0.0068
Onchocerca volvulus 0.0056 0.0449 0.0807
Onchocerca volvulus 0.0019 0.0017 0.0031
Brugia malayi conserved hypotetical protein 0.0029 0.0134 0.0182
Echinococcus granulosus transcription factor btf3 0.0038 0.024 0.024
Plasmodium falciparum JmjC domain-containing protein, putative 0.0043 0.03 0.2089
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0221 0.2417 0.2417
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0033 0.0181 0.0515
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0897 0.0897
Echinococcus multilocularis isocitrate dehydrogenase 0.0068 0.0592 0.0592
Brugia malayi amine oxidase, flavin-containing family protein 0.0105 0.104 0.1416
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Brugia malayi Patched protein homolog 1 0.0019 0.0017 0.0023
Toxoplasma gondii SWIRM domain-containing protein 0.0024 0.0077 0.0104
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma brucei protein kinase, putative 0.0054 0.0426 0.0534
Brugia malayi RNA binding protein 0.0128 0.131 0.1783
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0523 0.0523
Onchocerca volvulus 0.0056 0.0449 0.0807
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0291 0.3257 0.4406
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0137 0.1423 0.1937
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0231
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0068 0.0592 0.0761
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Echinococcus granulosus Dipeptidyl peptidase 9 0.0208 0.2266 0.2266
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0426 0.0426
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.0048
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0048 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0403 0.0549
Schistosoma mansoni cpg binding protein 0.0064 0.0544 0.0544
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0249 0.2761 0.2761
Loa Loa (eye worm) hypothetical protein 0.0335 0.3781 0.5147
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Mycobacterium ulcerans beta-lactamase 0.0035 0.0207 0.0271
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0048 0.023
Onchocerca volvulus 0.0019 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0523 0.0523
Schistosoma mansoni slit 0.0018 0.0003 0.0003
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0181 0.0247
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Brugia malayi hypothetical protein 0.0133 0.137 0.1864
Leishmania major basic transcription factor 3a, putative 0.0038 0.024 0.0638
Loa Loa (eye worm) hypothetical protein 0.032 0.36 0.4901
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1671 0.2275
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Brugia malayi CHE-14 protein 0.0137 0.1423 0.1937
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0084 0.0793 0.1079
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.0897 0.0897
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0134 0.0182
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Leishmania major UDP-galactopyranose mutase 0.0081 0.0749 0.2217
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Brugia malayi hypothetical protein 0.0019 0.0017 0.0023
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Schistosoma mansoni kinase 0.0048 0.0353 0.0353
Brugia malayi MH2 domain containing protein 0.013 0.1338 0.1822
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0207 0.0207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0523 0.0523
Onchocerca volvulus 0.0051 0.0395 0.071
Onchocerca volvulus 0.0022 0.0048 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0133 0.137 0.1825
Onchocerca volvulus Peroxidase homolog 0.0056 0.0449 0.0807
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0339 0.0415
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0081 0.0749 0.5414
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.8198 0.8198
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0523 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.1423 0.1893
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0395 0.0538
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0181 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0134 0.0134
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Brugia malayi nuclear hormone receptor 0.0029 0.0134 0.0182
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0181 0.0455
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Trypanosoma brucei polo-like protein kinase 0.0093 0.0897 0.1179
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0035 0.0035
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0239
Echinococcus multilocularis tar DNA binding protein 0.0128 0.131 0.131
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0208 0.2266 0.3051
Brugia malayi hypothetical protein 0.0081 0.0749 0.102
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0207 0.0282
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Schistosoma mansoni dishevelled 0.0019 0.0012 0.0012
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.028 0.3121 0.3121
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1338 0.1822
Onchocerca volvulus 0.0022 0.0048 0.0087
Echinococcus multilocularis protein dispatched 1 0.0157 0.1654 0.1654
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0207 0.1406
Mycobacterium ulcerans hypothetical protein 0.0075 0.0686 0.1023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0035 0.0035
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0181 0.02
Plasmodium vivax JmjC domain containing protein 0.0043 0.03 0.2089
Loa Loa (eye worm) glutaminase 0.0554 0.6399 0.871
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0077 0.0057
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Giardia lamblia Rrm3p helicase 0.0291 0.3257 1
Schistosoma mansoni nuclear receptor 0.0029 0.0134 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0291 0.3257 0.4396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0523 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0523 0.0712
Toxoplasma gondii histone lysine-specific demethylase 0.0081 0.0749 0.102
Schistosoma mansoni peroxidasin 0.0056 0.0452 0.0452
Onchocerca volvulus 0.0035 0.0207 0.0372
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0686 0.0888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1754 0.1754
Brugia malayi hypothetical protein 0.0086 0.0808 0.11
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.1197 0.1589
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0523 0.0523
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0012 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0175 0.0175
Brugia malayi hypothetical protein 0.0029 0.0134 0.0182
Schistosoma mansoni peroxidasin 0.0056 0.0449 0.0449
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Brugia malayi hypothetical protein 0.0033 0.0175 0.0239
Loa Loa (eye worm) hypothetical protein 0.0484 0.5562 0.7571
Mycobacterium tuberculosis Possible oxidoreductase 0.0081 0.0749 0.2254
Schistosoma mansoni dishevelled 0.0019 0.0012 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0523 0.0523
Plasmodium falciparum phd finger protein, putative 0.0029 0.0127 0.0813
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0127 0.0127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0459 0.0665
Loa Loa (eye worm) hypothetical protein 0.0108 0.1069 0.1454
Toxoplasma gondii LsmAD domain-containing protein 0.0133 0.137 0.1864
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0523 0.0523
Brugia malayi EGF-like domain containing protein 0.0018 0.0003 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Echinococcus multilocularis peregrin 0.0029 0.0127 0.0127
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0216 0.0294
Loa Loa (eye worm) hypothetical protein 0.0098 0.096 0.1307
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0048 0.023
Echinococcus granulosus JmjC domain containing protein 4 0.0043 0.03 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0395 0.0395
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0181 0.02
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0181 0.0557
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0127 0.0173
Leishmania major hypothetical protein, conserved 0.0051 0.0395 0.1118
Loa Loa (eye worm) hypothetical protein 0.0136 0.141 0.1919
Schistosoma mansoni alpha glucosidase 0.0035 0.0204 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0207 0.0235
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0043 0.03 0.0408
Entamoeba histolytica cysteine protease, putative 0.0022 0.0048 0.0018
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0081 0.0749 0.1123
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0207 0.2246
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0749 0.2254
Loa Loa (eye worm) hypothetical protein 0.0168 0.1791 0.2438
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Brugia malayi TAR-binding protein 0.0128 0.131 0.1783
Schistosoma mansoni hypothetical protein 0.0548 0.6321 0.6321
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0523 0.0712
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0422 0.1251
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0134 0.0134
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Echinococcus granulosus jumonji domain containing protein 0.004 0.0261 0.0261
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0207 0.0594
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Brugia malayi MAP kinase sur-1 0.0054 0.0426 0.0579
Onchocerca volvulus 0.0022 0.0048 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Echinococcus granulosus GPCR family 2 0.0098 0.096 0.096
Onchocerca volvulus 0.0019 0.0017 0.0031
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0035 0.0133
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.1464 0.1993
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Brugia malayi tailless protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) ICD-1 protein 0.0038 0.024 0.0327
Brugia malayi Blistered cuticle protein 3 0.0056 0.0449 0.0611
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0459 0.3264
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.005 0.0068
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0068 0.0592 0.4249
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0325 0.3659 0.3659
Echinococcus granulosus Niemann Pick C1 protein 0.0457 0.5237 0.5237
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0426 0.0533
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0012 0.0012
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1671 0.2275
Brugia malayi Muscleblind-like protein 0.0166 0.1766 0.2403
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0043 0.03 0.0362
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0181 0.02
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.005 0.0024
Onchocerca volvulus 0.0029 0.0134 0.024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.096 0.096
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.1197 0.1585
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.0258 0.0304
Loa Loa (eye worm) oxidoreductase 0.0022 0.005 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Brugia malayi hypothetical protein 0.0042 0.0283 0.0385
Mycobacterium ulcerans lipase LipD 0.0035 0.0207 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0339 0.0415
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0181 0.0181
Mycobacterium ulcerans dehydrogenase 0.0081 0.0749 0.1123
Echinococcus multilocularis cpg binding protein 0.0064 0.0544 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0116 0.0355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0258 0.0351
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0523 0.0523
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.005 0.0068
Echinococcus granulosus Niemann Pick C1 protein 0.032 0.36 0.36
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 0.9976
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0081 0.0749 1
Schistosoma mansoni lipoxygenase 0.0174 0.1866 0.1866
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0634 0.7347 0.7347
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0523 0.0523
Brugia malayi ecdysteroid receptor 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0686 0.206
Brugia malayi prolyl oligopeptidase family protein 0.0208 0.2266 0.3085
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0012 0.0012
Schistosoma mansoni polycystin 1-related 0.0042 0.0283 0.0283
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0523 0.0523
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0316 0.3555 0.4839
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.0467 0.1433
Entamoeba histolytica DNA repair and recombination protein, putative 0.0291 0.3257 0.4396
Chlamydia trachomatis protoporphyrinogen oxidase 0.0081 0.0749 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.131 0.131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0523 0.0712
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.096 0.096
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Onchocerca volvulus 0.0035 0.0207 0.0372
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0496 0.0496
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0204 0.0278
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0207 0.0282
Onchocerca volvulus Alhambra homolog 0.0029 0.0127 0.0228
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0304
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Schistosoma mansoni lipoxygenase 0.0249 0.2761 0.2761
Brugia malayi jmjC domain containing protein 0.0221 0.2417 0.329
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0523 0.0523
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0208 0.2266 0.2266
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0374 0.4242 0.6612
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0181 0.02
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0283 0.0385
Echinococcus multilocularis lysine specific demethylase 5A 0.0162 0.1713 0.1713
Loa Loa (eye worm) hypothetical protein 0.0077 0.07 0.0952
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0134 0.0182
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.0897 0.1221
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0128 0.1307 0.1307
Schistosoma mansoni hypothetical protein 0.0132 0.1364 0.1364
Onchocerca volvulus Dual oxidase homolog 0.0056 0.0449 0.0807
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0686 0.1023
Onchocerca volvulus Huntingtin homolog 0.0136 0.141 0.2534
Trypanosoma cruzi oligopeptidase b 0.0033 0.0181 0.02
Onchocerca volvulus 0.0022 0.005 0.009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Toxoplasma gondii patched family protein 0.0019 0.0017 0.0023
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0181 0.02
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0075 0.0075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.096 0.1307
Onchocerca volvulus 0.0075 0.0686 0.1234
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Schistosoma mansoni hypothetical protein 0.0098 0.096 0.096
Loa Loa (eye worm) DR-78 0.0029 0.0134 0.0182
Brugia malayi Myosin head containing protein 0.0019 0.0017 0.0023
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0634 0.7347 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0181 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.032 0.36 0.4865
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0048 0.0018
Brugia malayi hypothetical protein 0.0042 0.0283 0.0385
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0283 0.0283
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0035 0.0066
Brugia malayi NAD-dependent deacetylase SIRT1 0.0123 0.1253 0.1706
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0291 0.3257 0.3257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0247
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0523 0.0523
Brugia malayi hypothetical protein 0.0136 0.141 0.1919
Schistosoma mansoni ap endonuclease 0.0021 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Mycobacterium ulcerans oxidoreductase 0.0081 0.0749 0.1123
Brugia malayi Cathepsin L-like precursor 0.0022 0.0048 0.0065
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Onchocerca volvulus 0.0091 0.0876 0.1575
Mycobacterium ulcerans glutaminase 0.0554 0.6399 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.005 0.0244
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0181 0.0181
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0208 0.2266 0.3051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0207 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0523 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0523 0.0712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.137 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0204 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Trypanosoma cruzi oligopeptidase b 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.005 0.0113
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0048 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0068 0.0592 0.0592
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0033 0.0181 0.023
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0523 0.0523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1754 0.1754
Loa Loa (eye worm) hypothetical protein 0.0067 0.0583 0.0793
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.0258 0.0304
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.0258 0.0258
Onchocerca volvulus 0.0484 0.5562 1
Echinococcus granulosus cathepsin l1 0.0022 0.0048 0.0048
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0133 0.137 0.1864
Plasmodium falciparum ataxin-2 like protein, putative 0.0133 0.137 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0134 0.0182
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0426 0.0534
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1144 0.1558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0258 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0686 0.0934
Brugia malayi Kringle domain containing protein 0.0051 0.0395 0.0538
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0134 0.0182
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0123 0.1253 0.3848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Plasmodium vivax ataxin-2 like protein, putative 0.0133 0.137 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0056 0.0459 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0523 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0503 0.0685
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1671 0.1671
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0374 0.4242 0.6612
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0181 0.02
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0207 0.0594
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0311 0.349 0.349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0523 0.0712
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0207 0.0235
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0749 0.5414
Echinococcus granulosus RUN 0.0042 0.0283 0.0283
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0012 0.0012
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0311 0.3499 0.4762
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0523 0.0523
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0175 0.0175
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0686 0.2021
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.0897 0.1179
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0077 0.0057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0426 0.0534
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0686 0.0888
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Brugia malayi Niemann-Pick C1 protein precursor 0.032 0.36 0.4901
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.005 0.0024
Onchocerca volvulus Huntingtin homolog 0.0136 0.141 0.2534
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0134 0.024
Schistosoma mansoni transcription factor btf3 0.0038 0.024 0.024
Schistosoma mansoni amine oxidase 0.0081 0.0749 0.0749
Brugia malayi Latrophilin receptor protein 2 0.0098 0.096 0.1307
Trichomonas vaginalis esterase, putative 0.0035 0.0207 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0175 0.0175
Trypanosoma cruzi UDP-galactopyranose mutase 0.0081 0.0749 0.0977
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0048 0.0065
Brugia malayi Patched related family protein 10 0.0019 0.0017 0.0023
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0204 0.0231
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0282 0.3154 0.4255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Brugia malayi hypothetical protein 0.0019 0.0012 0.0016
Echinococcus granulosus lysine specific histone demethylase 1A 0.0081 0.0749 0.0749
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0134 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.005 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0201 0.2188 0.2188
Loa Loa (eye worm) ctsf protein 0.0022 0.0048 0.0065
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0115 0.116 0.116
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0048 0.0018
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.005 0.0113
Echinococcus multilocularis transcription factor btf3 0.0038 0.024 0.024
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.1155 0.1528
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Plasmodium vivax vivapain-2 0.0022 0.0048 0.023
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.0897 0.0897
Onchocerca volvulus Slit protein homolog 0.0018 0.0003 0.0005
Brugia malayi beta-NAC-like protein 0.0038 0.024 0.0327
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0048 0.0048
Brugia malayi glutaminase DH11.1 0.0554 0.6399 0.871
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0035 0.0107
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0134 0.0182
Echinococcus granulosus tumor protein p63 0.0354 0.4005 0.4005
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0207 0.0594
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0181 0.1878
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0686 0.1023
Echinococcus multilocularis jumonji domain containing 1A 0.0043 0.03 0.03
Plasmodium falciparum protoporphyrinogen oxidase 0.0081 0.0749 0.5414
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0523 0.0712
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0686 0.1023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0686 0.0888
Brugia malayi hypothetical protein 0.0033 0.0175 0.0239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0051 0.0395 0.0538
Brugia malayi Animal haem peroxidase family protein 0.0056 0.0449 0.0611
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0523 0.0523
Brugia malayi protein C24B5.3 0.0019 0.0017 0.0023
Toxoplasma gondii hypothetical protein 0.0033 0.0181 0.0247
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0139 0.1447 0.197
Schistosoma mansoni cpg binding protein 0.0064 0.0544 0.0544
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0081 0.0749 0.102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0068 0.0592 0.0805
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Brugia malayi ecdysone receptor 0.0029 0.0134 0.0182
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0395 0.2795
Brugia malayi Protein kinase domain containing protein 0.0053 0.0421 0.0572
Loa Loa (eye worm) hypothetical protein 0.0136 0.141 0.1919
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0068 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0056 0.0449 0.0611
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0175 0.0239
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.1197 0.1585
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.2324 0.3163
Brugia malayi AMP-binding enzyme family protein 0.0022 0.005 0.0068
Schistosoma mansoni hypothetical protein 0.0248 0.2741 0.2741
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0035 0.5
Schistosoma mansoni rab6-interacting 0.0042 0.0283 0.0283
Onchocerca volvulus 0.0052 0.0403 0.0725
Brugia malayi Doublecortin family protein 0.0042 0.0283 0.0385
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0426 0.0534
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0221 0.2417 0.2417
Loa Loa (eye worm) hypothetical protein 0.0081 0.0749 0.102
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0134 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0204 0.0231
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.005 0.0024
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0385 0.4381 0.7877
Schistosoma mansoni amine oxidase 0.0081 0.0749 0.0749
Brugia malayi DIX domain containing protein 0.0019 0.0012 0.0016
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0181 0.02
Schistosoma mansoni patched 1 0.0137 0.1423 0.1423
Brugia malayi beta-lactamase 0.0035 0.0207 0.0282
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.005 0.0021
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0181 0.02
Loa Loa (eye worm) hypothetical protein 0.0311 0.349 0.4751
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0016
Echinococcus multilocularis muscleblind protein 0.0166 0.1766 0.1766
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0181 0.02
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0181 0.02
Brugia malayi jmjC domain containing protein 0.0043 0.03 0.0408
Brugia malayi Peroxidasin 0.0056 0.0452 0.0615
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0181 0.0247
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0139 0.1447 0.1447
Onchocerca volvulus 0.0022 0.0048 0.0087
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0181 0.0455
Onchocerca volvulus 0.0035 0.0207 0.0372
Brugia malayi protein C24B5.3 0.0019 0.0017 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0204 0.0231
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.1197 0.1585
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Schistosoma mansoni hypothetical protein 0.0291 0.3257 0.3257
Toxoplasma gondii hypothetical protein 0.0019 0.0012 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0207 0.0235
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.131 0.1783
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.07 0.07
Schistosoma mansoni phd/f-box containing protein 0.0043 0.03 0.03
Brugia malayi CXXC zinc finger family protein 0.006 0.0503 0.0685
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2478 0.7549
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.005 0.0024
Brugia malayi nuclear receptor NHR-88 0.0062 0.0523 0.0712
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Leishmania major oligopeptidase b 0.0033 0.0181 0.0455
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Loa Loa (eye worm) patched family protein 0.0019 0.0017 0.0023
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0282
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0134 0.0134
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0523 0.0523
Schistosoma mansoni glutaminase 0.0554 0.6399 0.6399
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0523 0.094
Schistosoma mansoni chromatin regulatory protein sir2 0.0123 0.1253 0.1253
Loa Loa (eye worm) TAR-binding protein 0.0128 0.131 0.1783
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.005 0.0021
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.024 0.0281
Echinococcus multilocularis cysteine protease 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0247
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0048 0.0018
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0426 0.1307
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0012 0.0012
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0426 0.0534
Leishmania major cathepsin L-like protease 0.0022 0.0048 0.0041
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0048 0.0048
Brugia malayi hypothetical protein 0.0029 0.0134 0.0182
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0523 0.0523
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.03 0.0408
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0134 0.0134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Plasmodium falciparum peptidase, putative 0.0033 0.0181 0.1215
Mycobacterium tuberculosis Conserved protein 0.0035 0.0207 0.0594
Loa Loa (eye worm) animal heme peroxidase 0.0056 0.0449 0.0611
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0123 0.1253 0.1253
Trichomonas vaginalis glutaminase, putative 0.0554 0.6399 0.8683
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0897 0.1176
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0012 0.0012
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0123 0.1253 0.1253
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0204 0.0231
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0048 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Echinococcus multilocularis protoporphyrinogen oxidase 0.0081 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0029 0.0134 0.0182
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.005 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0395 0.2795
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Brugia malayi Patched family protein 0.0019 0.0017 0.0023
Brugia malayi nuclear hormone receptor 0.0062 0.0523 0.0712
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0686 0.9096
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0204 0.0231
Loa Loa (eye worm) hypothetical protein 0.0043 0.03 0.0408
Brugia malayi SWIRM domain containing protein 0.0024 0.0077 0.0104
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0081 0.0749 0.0749
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0048 0.0018
Brugia malayi beta-lactamase family protein 0.0035 0.0207 0.0282
Schistosoma mansoni loxhd1 0.0042 0.0283 0.0283
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.024 0.1652
Loa Loa (eye worm) hypothetical protein 0.01 0.0983 0.1339
Onchocerca volvulus 0.0019 0.0017 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0523 0.0712
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0123 0.1253 0.1662
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0139 0.1447 0.1447
Echinococcus granulosus lysine specific demethylase 6a 0.0043 0.03 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0048 0.0018
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0181 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0204 0.0231
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.1197 0.1585
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.024 0.028
Brugia malayi Patched related family protein 12 0.0019 0.0017 0.0023
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0395 0.0395
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0208 0.2266 0.2266

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 408 uM Binding affinity to human ERG ChEMBL. 21306895
IC50 (binding) = 1 nM Inhibition of human recombinant DPP4 after 60 mins by fluorescence plate reader ChEMBL. 21306895
IC50 (binding) = 13 uM Inhibition of human DPP9 expressed in african green monkey COS7 cells after 60 mins by fluorescence plate reader ChEMBL. 21306895
IC50 (binding) = 21 uM Inhibition of human DPP8 expressed in african green monkey COS7 cells after 60 mins by fluorescence plate reader ChEMBL. 21306895
IC50 (binding) > 100 uM Inhibition of rat DPP2 expressed in african green monkey COS7 cells after 60 mins by fluorescence plate reader ChEMBL. 21306895
IC50 (binding) > 100 uM Inhibition of APN ChEMBL. 21306895
IC50 (binding) > 100 uM Inhibition of POP in rat brain cortex ChEMBL. 21306895
Inhibition (ADMET) = 2.9 % Inhibition of CYP1A2 at 10 uM ChEMBL. 21306895
Inhibition (ADMET) = 3.5 % Inhibition of CYP3A4 at 10 uM ChEMBL. 21306895
Inhibition (ADMET) = 12.2 % Inhibition of CYP2D6 at 10 uM ChEMBL. 21306895
Inhibition (ADMET) = 26.8 % Inhibition of CYP2C9 at 10 uM ChEMBL. 21306895
Inhibition (ADMET) = 46.9 % Inhibition of CYP2C19 at 10 uM ChEMBL. 21306895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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