Detailed information for compound 1531244

Basic information

Technical information
  • TDR Targets ID: 1531244
  • Name: 3-[(5E)-5-[[4-[(4-chlorophenyl)methoxy]-3-met hoxyphenyl]methylidene]-4-oxo-2-sulfanylidene -1,3-thiazolidin-3-yl]benzoic acid
  • MW: 511.997 | Formula: C25H18ClNO5S2
  • H donors: 1 H acceptors: 3 LogP: 6.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1OCc1ccc(cc1)Cl)/C=C\1/SC(=S)N(C1=O)c1cccc(c1)C(=O)O
  • InChi: 1S/C25H18ClNO5S2/c1-31-21-11-16(7-10-20(21)32-14-15-5-8-18(26)9-6-15)12-22-23(28)27(25(33)34-22)19-4-2-3-17(13-19)24(29)30/h2-13H,14H2,1H3,(H,29,30)/b22-12+
  • InChiKey: GHKVGXGHSJFEEO-WSDLNYQXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(5E)-5-[[4-[(4-chlorophenyl)methoxy]-3-methoxy-phenyl]methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]benzoic acid
  • 3-[(5E)-5-[[4-[(4-chlorophenyl)methoxy]-3-methoxyphenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinyl]benzoic acid
  • 3-[(5E)-5-[4-(4-chlorobenzyl)oxy-3-methoxy-benzylidene]-4-keto-2-thioxo-thiazolidin-3-yl]benzoic acid
  • 3-[(5E)-5-[[4-[(4-chlorophenyl)methoxy]-3-methoxy-phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid
  • STK110394

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Starlite/ChEMBL No references
Homo sapiens protein tyrosine phosphatase, non-receptor type 12 Starlite/ChEMBL No references
Homo sapiens protein tyrosine phosphatase, non-receptor type 7 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Receptor type tyrosine protein phosphatase O Get druggable targets OG5_141408 All targets in OG5_141408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus receptor type tyrosine protein phosphatase protein tyrosine phosphatase, non-receptor type 7 434 aa 400 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0038 0.0391 0.1287
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0391 0.2119
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0203 0.0609
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Leishmania major hypothetical protein, conserved 0.0038 0.0391 0.1846
Entamoeba histolytica hypothetical protein 0.0035 0.0355 0.0422
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0048 0.0529 0.2616
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0452 0.1485
Onchocerca volvulus 0.0029 0.027 0.0896
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0048 0.0529 0.058
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.008 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0391 0.0429
Onchocerca volvulus 0.0048 0.0529 0.1893
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0191 0.0226
Brugia malayi prolyl oligopeptidase family protein 0.0015 0.008 0.0263
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0018 0.012 0.0333
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.015 0.0813
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0452 0.1485
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Onchocerca volvulus 0.0048 0.0529 0.1893
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0846 0.2736
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0048 0.0529 0.058
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0203 0.0609
Mycobacterium tuberculosis Conserved protein 0.0038 0.0391 0.1012
Schistosoma mansoni hypothetical protein 0.004 0.0419 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0097 0.0066
Trypanosoma cruzi prolyl endopeptidase 0.0145 0.1846 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0452 0.0495
Schistosoma mansoni lamin 0.0029 0.027 0.0296
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0146 0.048
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Leishmania major oligopeptidase b 0.0058 0.0658 0.3339
Mycobacterium leprae Probable lipase LipE 0.0038 0.0391 0.5414
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.017 0.2184 0.2395
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.014 0.178 0.548
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0203 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.012 0.0142
Entamoeba histolytica prolyl oligopeptidase family protein 0.0015 0.008 0.0095
Loa Loa (eye worm) fibroinase 0.0018 0.012 0.0333
Onchocerca volvulus Cathepsin L homolog 0.0018 0.012 0.0315
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0846 0.4581
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0058 0.0658 0.3562
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0048 0.0529 0.058
Leishmania major cathepsin L-like protease 0.0069 0.0813 0.4209
Loa Loa (eye worm) hypothetical protein 0.0147 0.1874 0.6139
Brugia malayi nuclear receptor RXR 0.002 0.0146 0.048
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0612 0.3314
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0062 0.0335
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0391 0.1012
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0452 0.1432
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0015 0.008 0.0433
Trichomonas vaginalis esterase, putative 0.0038 0.0391 0.0465
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0019 0.00000000036396
Brugia malayi Cytochrome P450 family protein 0.0055 0.0626 0.2059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Brugia malayi Protein-tyrosine phosphatase containing protein 0.017 0.2184 0.7181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0063
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.015 0.015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Schistosoma mansoni hypothetical protein 0.0035 0.0355 0.0389
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Onchocerca volvulus 0.002 0.0146 0.0416
Brugia malayi hypothetical protein 0.002 0.0146 0.048
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0452 0.0495
Echinococcus granulosus cathepsin l1 0.0018 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0452 0.0452
Schistosoma mansoni hypothetical protein 0.004 0.0419 0.0459
Schistosoma mansoni hypothetical protein 0.004 0.0419 0.0459
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0062 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0391 0.1012
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0813 0.4404
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.012 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0391 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0097 0.0066
Onchocerca volvulus 0.0048 0.0529 0.1893
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0048 0.0529 0.2864
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.012 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0452 0.1596
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0529 0.058
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0015 0.008 0.0088
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.011 0.2817
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0048 0.0529 0.058
Onchocerca volvulus 0.0018 0.012 0.0315
Loa Loa (eye worm) RecQ helicase 0.0026 0.0227 0.0687
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0391 0.0465
Loa Loa (eye worm) protein-tyrosine phosphatase 0.017 0.2184 0.7164
Brugia malayi ecdysone receptor 0.002 0.0146 0.048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0452 0.0452
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0529 0.058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Trypanosoma brucei oligopeptidase b 0.0058 0.0658 0.3562
Brugia malayi Nuclear hormone receptor E75 0.002 0.0146 0.048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0146 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0452 0.1432
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0452 0.1432
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0436 0.0478
Leishmania major cysteine peptidase A (CPA) 0.0018 0.012 0.0324
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0452 0.0495
Onchocerca volvulus 0.0048 0.0529 0.1893
Schistosoma mansoni protein tyrosine phosphatase 0.0048 0.0529 0.058
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Schistosoma mansoni cytochrome P450 0.0015 0.0077 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.015 0.0813
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0452 0.1596
Plasmodium vivax vivapain-2 0.0018 0.012 0.3058
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Brugia malayi Cathepsin L-like precursor 0.0012 0.0038 0.0125
Echinococcus multilocularis muscleblind protein 1 0.0147 0.1874 0.2055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0452 0.1485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0038 0.0045
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0203 0.263 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Onchocerca volvulus 0.0048 0.0529 0.1893
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.015 0.3835
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Brugia malayi intermediate filament protein 0.0029 0.027 0.0889
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0146 0.0146
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0048 0.0529 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0723 0.3914
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0146 0.048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0529
Loa Loa (eye worm) DR-78 0.002 0.0146 0.042
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0077 0.0316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0127
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0048 0.0529 0.1687
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Echinococcus granulosus intermediate filament protein 0.0029 0.027 0.027
Brugia malayi ecdysteroid receptor 0.0043 0.0452 0.1485
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0146 0.016
Brugia malayi hypothetical protein 0.0233 0.3041 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0109 0.0494
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0391 0.1012
Brugia malayi Doublecortin family protein 0.0022 0.017 0.0559
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0391 0.5414
Echinococcus multilocularis RUN 0.0022 0.017 0.0187
Mycobacterium tuberculosis Conserved protein 0.0038 0.0391 0.1012
Onchocerca volvulus 0.0018 0.012 0.0315
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0452 0.0495
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0452 0.0495
Onchocerca volvulus 0.0048 0.0529 0.1893
Brugia malayi hypothetical protein 0.0048 0.0529 0.1739
Brugia malayi Nuclear hormone receptor E75 0.002 0.0146 0.048
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0062 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0097 0.0066
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0452 0.0495
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1212 0.133
Brugia malayi hypothetical protein 0.0048 0.0529 0.1739
Brugia malayi hypothetical protein 0.0035 0.0355 0.1167
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0019 0.0021
Brugia malayi hypothetical protein 0.0048 0.0529 0.1739
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0146 0.016
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1758 0.1928
Giardia lamblia Alanyl dipeptidyl peptidase 0.0015 0.008 0.0233
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0048 0.0529 0.1687
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.017 0.0187
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0452 0.0452
Brugia malayi prolyl oligopeptidase family protein 0.0145 0.1846 0.6072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.027 0.0832
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0391 0.1012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus granulosus lamin dm0 0.0029 0.027 0.027
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0015 0.008 0.0095
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0077 0.0415
Echinococcus granulosus geminin 0.0184 0.237 0.237
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Onchocerca volvulus 0.0048 0.0529 0.1893
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.011 0.6
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Entamoeba histolytica hypothetical protein 0.0035 0.0355 0.0422
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0048 0.0529 0.0529
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.148 0.4836
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.027 0.0889
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0846 0.2781
Plasmodium vivax vivapain-2 0.0018 0.012 0.3058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.008 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0191 0.0366
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Onchocerca volvulus 0.0048 0.0529 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Echinococcus granulosus RUN 0.0022 0.017 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0391 0.0429
Echinococcus granulosus microsomal glutathione S transferase 3 0.0124 0.156 0.156
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.012 0.012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0048 0.0529 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0568
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.012 0.6513
Onchocerca volvulus 0.0018 0.012 0.0315
Brugia malayi nuclear hormone receptor 0.002 0.0146 0.048
Brugia malayi hypothetical protein 0.002 0.0146 0.048
Loa Loa (eye worm) ctsf protein 0.0018 0.012 0.0333
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0058 0.0658 1
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1758 0.1758
Loa Loa (eye worm) cysteine protease 0.0018 0.012 0.0333
Schistosoma mansoni lipoxygenase 0.0131 0.165 0.181
Giardia lamblia Protein tyrosine phosphatase 0.0048 0.0529 0.1953
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0452 0.1485
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0077 0.0415
Trichomonas vaginalis ap endonuclease, putative 0.002 0.015 0.0178
Brugia malayi Protein-tyrosine phosphatase 0.0048 0.0529 0.1739
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0452 0.0495
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0452 0.0495
Brugia malayi nuclear receptor RXR 0.0022 0.0179 0.0587
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.3185 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.012 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0452 0.1485
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0391 0.1232
Brugia malayi Cytochrome P450 family protein 0.0015 0.0077 0.0252
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0152 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Leishmania major tyrosine specific protein phosphatase, putative 0.0048 0.0529 0.2616
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0529
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.017 0.017
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0146 0.042
Schistosoma mansoni nuclear hormone receptor 0.002 0.0146 0.016
Onchocerca volvulus 0.0018 0.012 0.0315
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0048 0.0529 0.058
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0184 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1192 0.1307
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.0529
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0048 0.0529 0.2864
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.012 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.012 0.0393
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0146 0.016
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0439 0.0439
Echinococcus granulosus bloom syndrome protein 0.0026 0.0227 0.0227
Leishmania major cathepsin L-like protease 0.0018 0.012 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0048 0.0529 0.058
Echinococcus multilocularis lamin dm0 0.0029 0.027 0.0296
Brugia malayi beta-lactamase 0.0038 0.0391 0.1287
Echinococcus multilocularis musashi 0.0029 0.027 0.0296
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Loa Loa (eye worm) intermediate filament protein 0.0029 0.027 0.0832
Leishmania major cytochrome p450-like protein 0.0015 0.0077 0.0083
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0015 0.008 0.0161
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0191 0.0446
Schistosoma mansoni hypothetical protein 0.0015 0.0077 0.0084
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0146 0.0146
Mycobacterium ulcerans hypothetical protein 0.0023 0.0191 0.0446
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.148 0.4836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0452 0.1432
Mycobacterium ulcerans lipase LipD 0.0038 0.0391 0.1232
Loa Loa (eye worm) hypothetical protein 0.0233 0.3041 1
Brugia malayi cathepsin L-like precursor 0.0012 0.0038 0.0125
Brugia malayi Muscleblind-like protein 0.0147 0.1874 0.6163
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0145 0.1846 0.2025
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0452 0.0495
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0048 0.0529 0.058
Echinococcus multilocularis microtubule associated protein 2 0.068 0.9118 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.017 0.2184 0.2184
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0146 0.048
Brugia malayi prolyl oligopeptidase family protein 0.0015 0.008 0.0263
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0048 0.0529 0.1687
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.013 0.1639 0.5028
Brugia malayi hypothetical protein 0.0022 0.0179 0.0587
Onchocerca volvulus 0.0038 0.0391 0.1363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0146 0.016
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0203 0.1099
Schistosoma mansoni DNA helicase recq1 0.0011 0.0019 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0191 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0146 0.016
Schistosoma mansoni lamin 0.0029 0.027 0.0296
Echinococcus multilocularis 0.0015 0.0077 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0452 0.0495
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0452 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Toxoplasma gondii exonuclease III APE 0.002 0.015 0.0718
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0391 0.1232
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.012 0.0333
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0355 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0813 0.4404
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.017 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0452 0.1432
Echinococcus granulosus Dipeptidyl peptidase 9 0.0015 0.008 0.008
Echinococcus multilocularis prolyl endopeptidase 0.0145 0.1846 0.2025
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0191 0.0226
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0191 0.0446
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0452 0.0495
Schistosoma mansoni polycystin 1-related 0.0022 0.017 0.0187
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0146 0.0146
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0723 0.0859
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0062 0.0335
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0452 0.0495
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.012 0.6513
Trichomonas vaginalis pten, drome, putative 0.0048 0.0529 0.0628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0529
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0077 0.0083
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0146 0.0146
Onchocerca volvulus 0.0048 0.0519 0.1856
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0302
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0191 0.1959
Entamoeba histolytica cysteine protease, putative 0.0018 0.012 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0048 0.0529 0.0529
Onchocerca volvulus 0.0048 0.0529 0.1893
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.017 0.0187
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0391 0.1012
Trypanosoma brucei prolyl oligopeptidase, putative 0.0058 0.0658 0.3562
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0048 0.0529 0.058
Schistosoma mansoni nuclear hormone receptor 0.002 0.0146 0.016
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0048 0.0529 0.058
Schistosoma mansoni protein tyrosine phosphatase 0.0048 0.0529 0.058
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0145 0.1846 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.015 0.0287
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0146 0.0146
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0519 0.1707
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0391 0.2119
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.015 0.0502
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0202
Leishmania major cathepsin L-like protease 0.0018 0.012 0.0324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium ulcerans hypothetical protein 0.0038 0.0391 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0452 0.1485
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0452 0.0495
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0832
Onchocerca volvulus 0.0203 0.263 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0191 0.0446
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0065 0.0065
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0015 0.008 0.0088
Brugia malayi hypothetical protein 0.0022 0.0179 0.0587
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0813 0.4404
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.0529
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0355 0.0389
Echinococcus multilocularis protein dispatched 1 0.0048 0.0519 0.0569
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0191 0.0721
Leishmania major cathepsin L-like protease 0.0018 0.012 0.0324
Onchocerca volvulus 0.0038 0.0391 0.1363
Schistosoma mansoni hypothetical protein 0.004 0.0419 0.0459
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Trypanosoma brucei protein tyrosine phosphatase 1 0.0048 0.0529 0.2864
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0227 0.0269
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1192 0.1416
Brugia malayi beta-lactamase family protein 0.0038 0.0391 0.1287
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0048 0.0529 0.0529
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0203 0.1099
Brugia malayi nuclear hormone receptor 0.0043 0.0452 0.1485
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.263 0.3124
Plasmodium falciparum peptidase, putative 0.0015 0.008 0.4348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.015 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0452 0.1432
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Onchocerca volvulus Cathepsin L homolog 0.0018 0.012 0.0315
Onchocerca volvulus 0.0048 0.0529 0.1893
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0048 0.0529 0.2864
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0048 0.0529 0.058
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0019 0.0062
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0179 0.0196
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.05
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0227 0.0249
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0191 0.0626
Onchocerca volvulus 0.0048 0.0529 0.1893
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0203 0.1099
Trichomonas vaginalis ap endonuclease, putative 0.002 0.015 0.0178
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0391 0.1232
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0015 0.008 0.0088
Entamoeba histolytica prolyl oligopeptidase family protein 0.0015 0.008 0.0095
Brugia malayi prolyl oligopeptidase family protein 0.0015 0.008 0.0263
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0179 0.0196
Leishmania major cathepsin L-like protease 0.0018 0.012 0.0324
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.012 0.012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0452 0.0452
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0015 0.008 0.0433
Loa Loa (eye worm) hypothetical protein 0.0051 0.0566 0.1811
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0038 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0058 0.0658 0.3339
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0302
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0048 0.0529 0.058
Loa Loa (eye worm) prolyl oligopeptidase 0.0015 0.008 0.0202
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0846 0.0928
Schistosoma mansoni zinc finger protein 0.002 0.0146 0.016
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0723 0.3914
Schistosoma mansoni ap endonuclease 0.002 0.015 0.0165
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.015 0.8168
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0015 0.008 0.0333
Onchocerca volvulus 0.0048 0.0529 0.1893
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.012 0.0142
Onchocerca volvulus 0.0048 0.0529 0.1893
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0015 0.008 0.008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0846 0.4581
Toxoplasma gondii prolyl endopeptidase 0.0145 0.1846 1
Brugia malayi prolyl oligopeptidase family protein 0.0015 0.008 0.0263
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0452 0.0495
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0452 0.1485
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0529 0.058
Trypanosoma cruzi oligopeptidase b 0.0058 0.0658 0.3562
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Leishmania major cytochrome p450-like protein 0.0015 0.0077 0.0083
Onchocerca volvulus 0.0048 0.0529 0.1893
Trypanosoma cruzi oligopeptidase b 0.0058 0.0658 0.3562
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0846 0.4393
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Toxoplasma gondii cathepsin CPL 0.0018 0.012 0.0551
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0203 0.263 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0452 0.1432
Schistosoma mansoni lipoxygenase 0.0091 0.1116 0.1224
Giardia lamblia Alanyl dipeptidyl peptidase 0.0015 0.008 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0452 0.1485
Brugia malayi hypothetical protein 0.0048 0.0529 0.1739
Echinococcus multilocularis expressed conserved protein 0.0091 0.1112 0.1219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.263 0.3124
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0846 0.0928
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0048 0.0529 0.058
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.017 0.017
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0452 0.1596
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Mycobacterium ulcerans beta-lactamase 0.0038 0.0391 0.1232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0452 0.1485
Schistosoma mansoni pcd6 interacting protein-related 0.0048 0.0529 0.058
Brugia malayi CHE-14 protein 0.0042 0.0439 0.1443
Onchocerca volvulus 0.0022 0.017 0.0509
Schistosoma mansoni hypothetical protein 0.0022 0.017 0.0187
Brugia malayi conserved hypotetical protein 0.002 0.0146 0.048
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0179 0.0529
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0529 0.058
Entamoeba histolytica hypothetical protein 0.0035 0.0355 0.0422
Toxoplasma gondii MAPEG family protein 0.0124 0.156 0.843
Loa Loa (eye worm) hypothetical protein 0.0131 0.1654 0.541
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0022 0.017 0.05
Schistosoma mansoni DNA helicase recq5 0.0011 0.0019 0.0021
Onchocerca volvulus 0.0018 0.012 0.0315
Brugia malayi cytochrome P450 0.0015 0.0077 0.0252
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0077 0.0415
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0179 0.0587
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0191 0.0446
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.263 0.3124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Onchocerca volvulus 0.0048 0.0529 0.1893
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0391 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Toxoplasma gondii hypothetical protein 0.0015 0.008 0.0333
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0146 0.042
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0452 0.1485
Onchocerca volvulus 0.0048 0.0529 0.1893
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0628 0.8416 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0391 0.1012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0846 0.4581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Schistosoma mansoni loxhd1 0.0022 0.017 0.0187
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0227 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0452 0.1485
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0452 0.0495
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0146 0.0146
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0015 0.008 0.0088
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0146 0.016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0391 0.1012
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.017 0.9257
Leishmania major cathepsin L-like protease 0.0069 0.0813 0.4209
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0048 0.0529 0.058
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.165 0.181
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0452 0.1485
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0191 0.0446
Echinococcus multilocularis protein patched 0.0042 0.0439 0.0481
Schistosoma mansoni hypothetical protein 0.0184 0.237 0.2599
Schistosoma mansoni hypothetical protein 0.0048 0.0519 0.0569
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.015 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.012 0.0131
Leishmania major hypothetical protein, conserved 0.0063 0.0723 0.3703
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0203 0.263 0.8647
Brugia malayi Protein-tyrosine phosphatase 0.0048 0.0529 0.1739
Brugia malayi MH2 domain containing protein 0.0118 0.148 0.4868
Entamoeba histolytica hypothetical protein 0.0035 0.0355 0.0422
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Onchocerca volvulus 0.0018 0.012 0.0315
Onchocerca volvulus 0.0023 0.0191 0.0588
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0086 0.0282
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.017 0.2184 0.2395
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0391 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0391 0.1287
Schistosoma mansoni nuclear receptor 0.002 0.0146 0.016
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0015 0.008 0.0101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0452 0.0495
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0058 0.0658 0.1869
Onchocerca volvulus 0.0043 0.0452 0.1596
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.165 0.165
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0097 0.0066
Leishmania major cytochrome p450-like protein 0.0024 0.0203 0.079
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0355 0.0355
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0628 0.8416 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0541 0.7233 0.7932
Brugia malayi Cathepsin L-like precursor 0.0012 0.0038 0.0125
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.015 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0302
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0048 0.0529 0.058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0191 0.0446
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0529 0.058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0452 0.1485
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0048 0.0529 0.058
Leishmania major cathepsin L-like protease 0.0069 0.0813 0.4209
Loa Loa (eye worm) hypothetical protein 0.0029 0.0263 0.0808
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0391 0.0465
Brugia malayi steroid hormone receptor 0.0043 0.0452 0.1485
Onchocerca volvulus Prolyl endopeptidase homolog 0.0145 0.1846 0.6978
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0015 0.008 0.0088
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0015 0.008 0.0433
Loa Loa (eye worm) prolyl oligopeptidase 0.0015 0.008 0.0202
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.015 0.0494
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.017 0.2184 0.2395
Onchocerca volvulus 0.0048 0.0529 0.1893
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0391 0.2119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.015 0.0165
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0227 0.0745
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0015 0.008 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.012 0.0648
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Schistosoma mansoni hypothetical protein 0.0184 0.237 0.2599
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.011 0.0108
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1192 0.3919
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0191 0.0226
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0391 0.0429
Onchocerca volvulus 0.0022 0.017 0.0509
Onchocerca volvulus 0.002 0.0146 0.0416
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Echinococcus multilocularis cysteine protease 0.0018 0.012 0.0131
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0065 0.0071
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0015 0.008 0.0433
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.012 0.0131
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.263 0.3124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Schistosoma mansoni rab6-interacting 0.0022 0.017 0.0187
Loa Loa (eye worm) doublecortin family protein 0.0022 0.017 0.05
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0048 0.0529 0.058
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0015 0.008 0.0088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0191 0.0366
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0058 0.0658 0.3562
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0813 0.4404
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0086 0.0221
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Echinococcus multilocularis hypothetical protein 0.0048 0.0529 0.058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Schistosoma mansoni coup transcription factor 0.0043 0.0452 0.0495
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0452 0.0495
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.263 0.3124
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0723 0.0859
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0019 0.0062
Brugia malayi Cytochrome P450 family protein 0.0024 0.0203 0.0667
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.011 0.0131
Echinococcus granulosus acylamino acid releasing enzyme 0.0015 0.008 0.008
Schistosoma mansoni intermediate filament proteins 0.0029 0.027 0.0296
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.263 0.3124
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0179 0.0196
Onchocerca volvulus 0.0048 0.0529 0.1893
Echinococcus granulosus prolyl endopeptidase 0.0145 0.1846 0.1846
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0015 0.008 0.0095
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0019 0.103
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.012 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.1232
Onchocerca volvulus 0.0018 0.012 0.0315
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0048 0.0529 0.1739
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0529
Onchocerca volvulus 0.0038 0.0391 0.1363
Onchocerca volvulus 4.1 G protein, putative homolog 0.0048 0.0529 0.1893
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.263 0.3124
Brugia malayi Protein-tyrosine phosphatase 1 0.0048 0.0529 0.1739
Schistosoma mansoni protein tyrosine phosphatase 0.0048 0.0529 0.058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0452 0.1485
Onchocerca volvulus 0.0048 0.0529 0.1893
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Brugia malayi Cytochrome P450 family protein 0.0024 0.0203 0.0667
Toxoplasma gondii ABC1 family protein 0.0038 0.0391 0.2037
Brugia malayi tailless protein 0.002 0.0146 0.048
Loa Loa (eye worm) hypothetical protein 0.0097 0.1192 0.3881
Echinococcus granulosus microtubule associated protein 2 0.068 0.9118 0.9118
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.012 0.0131
Trypanosoma brucei prolyl endopeptidase 0.0145 0.1846 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0452 0.1485
Schistosoma mansoni ap endonuclease 0.002 0.015 0.0165
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0439 0.0439
Brugia malayi nuclear receptor NHR-88 0.0043 0.0452 0.1485
Brugia malayi Cathepsin L-like precursor 0.0018 0.012 0.0393
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.017 0.017
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0019 0.0019
Schistosoma mansoni nuclear receptor 0.002 0.0146 0.016
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.015 0.0493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0063
Mycobacterium tuberculosis Conserved protein 0.0038 0.0391 0.1012
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0124 0.156 0.171
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0731 0.3962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.008 0.0433
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0626 0.2009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0191 0.1959
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0191 0.0626
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.015 0.0434
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Brugia malayi nuclear receptor NHR-88 0.002 0.0146 0.048
Loa Loa (eye worm) hypothetical protein 0.0145 0.1846 0.6047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0452 0.0495
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0391 0.0391
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.017 0.2184 0.2184
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0439 0.0481
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0436 0.0436
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.015 0.0236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0452 0.1432
Leishmania major cathepsin L-like protease 0.0018 0.012 0.0324
Entamoeba histolytica prolyl oligopeptidase family protein 0.0015 0.008 0.0095
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0452 0.0495
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0439 0.0522
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0048 0.0529 0.1739
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Plasmodium vivax hypothetical protein, conserved 0.0015 0.008 0.2041
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0179 0.0587
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0015 0.008 0.0433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0179 0.0529
Brugia malayi nuclear receptor NHR-67 0.002 0.0146 0.048
Echinococcus multilocularis cysteine protease 0.0018 0.012 0.0131
Schistosoma mansoni rab6-interacting 0.0022 0.017 0.0187
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0146 0.016
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0048 0.0529 0.058
Brugia malayi hypothetical protein 0.0048 0.0529 0.1739
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0179 0.0179
Brugia malayi hypothetical protein 0.0022 0.017 0.0559
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.058
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.017 0.4346
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.011 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0015 0.008 0.0095
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0038 0.0045
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.3041 0.3041
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0191 0.0446
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0038 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0452 0.0452
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.012 0.0142
Echinococcus multilocularis geminin 0.0184 0.237 0.2599
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0048 0.0529 0.058
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0146 0.0416
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.0529
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.012 0.6513
Echinococcus granulosus lamin 0.0029 0.027 0.027
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0023 0.0191 0.0568
Onchocerca volvulus 0.0048 0.0529 0.1893
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0015 0.008 0.0333
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.263 0.3124
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0191 0.0626
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0146 0.016
Onchocerca volvulus 0.0048 0.0529 0.1893
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Mycobacterium tuberculosis Probable peptidase 0.0058 0.0658 0.1869
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0038 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0127
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0529 0.058
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0077 0.0077
Schistosoma mansoni patched 1 0.0042 0.0439 0.0481
Loa Loa (eye worm) protein tyrosine phosphatase 0.0048 0.0529 0.1687
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0439 0.139
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0391 0.0465
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.012 0.0142
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Echinococcus granulosus expressed conserved protein 0.0091 0.1112 0.1112
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0203 0.0609
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0077 0.0415
Schistosoma mansoni microtubule-associated protein tau 0.068 0.9118 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0146 0.048
Loa Loa (eye worm) beta-lactamase 0.0038 0.0391 0.1232
Loa Loa (eye worm) cytochrome P450 0.0015 0.0077 0.0191
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.042
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0146 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0452 0.1485
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0145 0.1846 0.2025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0151
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0191 0.0721
Echinococcus granulosus protein tyrosine phosphatase n9 0.0048 0.0529 0.0529
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Echinococcus granulosus muscleblind protein 0.0147 0.1874 0.1874
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.0529 0.1739
Onchocerca volvulus 0.0048 0.0529 0.1893
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.0529 0.1687
Onchocerca volvulus Cathepsin F homolog 0.0018 0.012 0.0315
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.015 0.0813
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0058 0.0658 0.3562
Loa Loa (eye worm) hypothetical protein 0.0043 0.0452 0.1432
Loa Loa (eye worm) hypothetical protein 0.0042 0.0439 0.139
Loa Loa (eye worm) hypothetical protein 0.0048 0.0529 0.1687
Loa Loa (eye worm) hypothetical protein 0.0147 0.1874 0.6139
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0723 0.3914
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0846 0.0846
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0203 0.263 0.8639
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.3041 0.3335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0813 0.4404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.012 0.0142
Onchocerca volvulus 0.0029 0.027 0.0896
Schistosoma mansoni survival motor neuron protein 0.0048 0.0519 0.0569
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0146 0.042
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0846 0.1005
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1192 0.1192
Echinococcus granulosus cathepsin l1 0.0012 0.0038 0.0038
Echinococcus multilocularis muscleblind protein 0.0147 0.1874 0.2055
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0112 0.2865
Echinococcus multilocularis 0.0048 0.0529 0.058
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0048 0.0529 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.008 0.0095
Echinococcus multilocularis acylamino acid releasing enzyme 0.0015 0.008 0.0088
Schistosoma mansoni microsomal glutathione s-transferase 0.0124 0.156 0.171
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0048 0.0529 0.058
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0452 0.0452
Echinococcus multilocularis lamin 0.0029 0.027 0.0296
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0452 0.0495
Onchocerca volvulus 0.0048 0.0529 0.1893
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0048 0.0529 0.0628
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0048 0.0529 0.0628
Brugia malayi hypothetical protein 0.0022 0.017 0.0559
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0058 0.0658 0.2276

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.394 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit HePTP - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1059, AID1077, AID1784, AID2085, AID521] ChEMBL. No reference
IC50 (functional) = 0.953 uM PUBCHEM_BIOASSAY: SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135] ChEMBL. No reference
IC50 (functional) = 3.06 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID2686] ChEMBL. No reference
IC50 (functional) = 3.49 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID2682] ChEMBL. No reference
IC50 (functional) = 3.68 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using pCAP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2135, AID449727] ChEMBL. No reference
IC50 (functional) = 4.04 uM PUBCHEM_BIOASSAY: SAR LYP1 Fluorescent Assay using OMFP substrate for In Vitro dose response studies - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1779, AID1784, AID2140, AID449726, AID488869] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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