Detailed information for compound 1541549

Basic information

Technical information
  • TDR Targets ID: 1541549
  • Name: [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyri midin-1-yl)oxolan-2-yl]methoxy-N-[(2S)-1-meth oxy-1-oxo-3-phenylpropan-2-yl]phosphonamidic acid
  • MW: 508.422 | Formula: C20H25N6O8P
  • H donors: 3 H acceptors: 5 LogP: 1.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)[C@@H](NP(=O)(OC[C@H]1O[C@H](C[C@@H]1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O)O)Cc1ccccc1
  • InChi: 1S/C20H25N6O8P/c1-12-10-26(20(29)22-18(12)27)17-9-14(23-25-21)16(34-17)11-33-35(30,31)24-15(19(28)32-2)8-13-6-4-3-5-7-13/h3-7,10,14-17H,8-9,11H2,1-2H3,(H,22,27,29)(H2,24,30,31)/t14-,15-,16+,17+/m0/s1
  • InChiKey: LLKRILRSWBGHEO-MWDXBVQZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-N-[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]phosphonamidic acid
  • [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2-tetrahydrofuranyl]methoxy-N-[(1S)-2-methoxy-2-oxo-1-(phenylmethyl)ethyl]phosphonamidic acid
  • [(2S,3S,5R)-3-azido-5-(2,4-diketo-5-methyl-pyrimidin-1-yl)tetrahydrofuran-2-yl]methoxy-N-[(1S)-1-(benzyl)-2-keto-2-methoxy-ethyl]phosphonamidic acid
  • [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy-N-[(2S)-1-methoxy-1-oxo-3-phenyl-propan-2-yl]phosphonamidic acid
  • AIDS-059287
  • AIDS059287
  • Methyl (2S)-2-[({[3-(azadiazomvinyl)-5-(5-methyl-2,4-dioxo(1,3-dihydropyrimidinyl))oxolan-2-yl]methoxy}(hydroxyphosphoryl))amino]-3-phenylpropanoate
  • Phosphoramidate diester of AZT
  • (S)-2-{[3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydrofuran-2-ylmethoxy]-hydroxyphosphorylamino}-3-phenylpropionic acid methyl ester
  • AIDS-228393
  • AIDS228393

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Brugia malayi Cathepsin L-like precursor 0.015 0.0074 0.0369
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0353 0.0201 0.098
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1233 0.0749 0.1878
Brugia malayi Pre-SET motif family protein 0.0428 0.0247 0.1234
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1233 0.0749 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0045 0.0008 0.0016
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1194 0.0725 0.1997
Loa Loa (eye worm) hypothetical protein 0.0525 0.0308 0.1536
Trichomonas vaginalis heat shock protein, putative 0.0063 0.002 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.077 0.046 0.2279
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.011 0.0049 0.0574
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trypanosoma cruzi heat shock protein 90, putative 0.0103 0.0045 0.0128
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0008 0.0041
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0045 0.0008 0.0037
Onchocerca volvulus 0.024 0.013 0.4556
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.0725 0.3607
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.006 0.0018 0.0051
Schistosoma mansoni glutaminase 0.3243 0.2002 0.5022
Giardia lamblia Kinase, PLK 0.008 0.003 0.03
Brugia malayi MH1 domain containing protein 0.0102 0.0044 0.0217
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0148 0.0072 0.4246
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.037 0.0211 0.7421
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Loa Loa (eye worm) hypothetical protein 0.0449 0.026 0.1299
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0243 0.0132 0.0131
Plasmodium vivax vivapain-3 0.0117 0.0053 0.2995
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Giardia lamblia Phosphatidylinositol 4-kinase 0.024 0.013 0.1669
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi cathepsin F-like cysteine proteinase 0.0045 0.0008 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0053 0.0241
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 0.0044 0.0218
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0161 0.2138
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.002 0.0178
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.0109 0.0108
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0008 0.0271
Giardia lamblia Heat shock protein HSP 90-alpha 0.0103 0.0045 0.0501
Schistosoma mansoni kinase 0.0041 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0525 0.0308 0.077
Trypanosoma brucei poly(adp-ribose) polymerase 0.006 0.0018 0.0226
Plasmodium falciparum phosphatidylinositol 4-kinase 0.024 0.013 0.3007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.0247 0.1234
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1233 0.0749 0.2152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0012 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0685 0.0407 0.2014
Echinococcus granulosus carbonic anhydrase II 0.129 0.0785 0.0784
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0092 0.0037 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Plasmodium falciparum cysteine proteinase falcipain 1 0.0117 0.0053 0.1131
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0688 0.0409 0.1026
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.006 0.0018 0.0051
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0674 0.04 0.04
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0019 0.0164
Echinococcus multilocularis heat shock protein 90 0.0103 0.0045 0.0044
Trypanosoma cruzi cysteine protease, putative 0.0117 0.0053 0.0152
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Trypanosoma brucei heat shock protein 90, putative 0.0103 0.0045 0.0569
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0102 0.0044 0.0043
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Loa Loa (eye worm) cathepsin B 0.0092 0.0037 0.0187
Echinococcus granulosus cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Toxoplasma gondii preprocathepsin c precursor, putative 0.0045 0.0008 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0749 0.0447 0.6098
Onchocerca volvulus Alhambra homolog 0.0063 0.002 0.0664
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0042 0.0007 0.0006
Onchocerca volvulus 0.0222 0.0119 0.4164
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0082 0.0032 0.167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0243 0.0132 0.0131
Echinococcus multilocularis heat shock protein 0.0103 0.0045 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Echinococcus multilocularis endoplasmin 0.0082 0.0032 0.0031
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Plasmodium vivax hypothetical protein, conserved 0.024 0.013 0.7961
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.129 0.0785 0.1967
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.051 0.0298 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0001 0.0003
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0025 0.0125
Echinococcus multilocularis mothers against decapentaplegic 5 0.0102 0.0044 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0 0.0001
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Brugia malayi MH1 domain containing protein 0.0056 0.0015 0.0076
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.0332 0.4456
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.024 0.013 0.1686
Schistosoma mansoni Smad4 0.0102 0.0044 0.0108
Schistosoma mansoni hypothetical protein 0.0255 0.014 0.0348
Loa Loa (eye worm) hypothetical protein 0.074 0.0441 0.2205
Schistosoma mansoni phosphatidylinositol 4-kinase 0.029 0.0161 0.0403
Brugia malayi hypothetical protein 0.074 0.0441 0.2204
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.006 0.0018 0.0017
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0699 0.0416 0.2078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0081 0.0031 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0699 0.0416 0.2077
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0674 0.04 0.04
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0042 0.0007 0.0006
Entamoeba histolytica heat shock protein 90, putative 0.0103 0.0045 0.0521
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0688 0.0409 0.1176
Plasmodium falciparum serine repeat antigen 4 0.0045 0.0008 0.0037
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1213 0.0736 0.0736
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.045 0.0261 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Plasmodium falciparum serine repeat antigen 5 0.0045 0.0008 0.0037
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.024 0.013 0.0324
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0092 0.0037 0.0092
Brugia malayi Cathepsin L-like precursor 0.015 0.0074 0.0369
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.024 0.013 0.7961
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0006 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0254 0.0139 0.0398
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0001 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1213 0.0736 0.9386
Brugia malayi mbt repeat family protein 0.0045 0.0008 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0001 0.0004
Echinococcus granulosus Smad4 0.0102 0.0044 0.0043
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Leishmania major hypothetical protein, unknown function 0.024 0.013 0.0357
Echinococcus multilocularis geminin 0.0255 0.014 0.0139
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Plasmodium falciparum serine repeat antigen 2 0.0045 0.0008 0.0037
Entamoeba histolytica cysteine protease, putative 0.0222 0.0119 0.1534
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0045 0.0008 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0001 0.0004
Leishmania major hypothetical protein, conserved 0.0181 0.0093 0.0257
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0051 0.0012 0.0061
Schistosoma mansoni smad 0.0102 0.0044 0.0108
Echinococcus granulosus histone acetyltransferase MYST2 0.0051 0.0012 0.0012
Echinococcus multilocularis cysteine protease 0.0222 0.0119 0.0118
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0008 0.0021
Leishmania major hypothetical protein, conserved 0.5854 0.3629 1
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0053 0.0264
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0008 0.0019
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0008 0.0098
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1213 0.0736 0.2029
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0009 0.0043
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0674 0.04 0.1151
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.129 0.0785 0.3919
Toxoplasma gondii heat shock protein 90, putative 0.0103 0.0045 0.0526
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.003 0.032
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Entamoeba histolytica cysteine proteinase 1, putative 0.0117 0.0053 0.0634
Plasmodium vivax unspecified product 0.0117 0.0053 0.2995
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi MH1 domain containing protein 0.0056 0.0015 0.0076
Trypanosoma cruzi target of rapamycin kinase 3 0.1204 0.0731 0.21
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1204 0.0731 0.2014
Echinococcus granulosus survival motor neuron protein 1 0.074 0.0441 0.0441
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0181 0.0093 0.0467
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.024 0.013 0.0129
Brugia malayi PHD-finger family protein 0.0063 0.002 0.0097
Echinococcus granulosus poly adp ribose polymerase 2 0.006 0.0018 0.0017
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Echinococcus granulosus cathepsin b 0.0196 0.0103 0.0102
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0148 0.0072 0.0072
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0025 0.0125
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0699 0.0416 0.1042
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0222 0.0119 0.2736
Brugia malayi MH2 domain containing protein 0.0102 0.0044 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Brugia malayi Endoplasmin precursor 0.0103 0.0045 0.0223
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0353 0.0201 0.098
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0467 0.0272 0.3616
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.024 0.013 0.7961
Trypanosoma brucei carbonic anhydrase-like protein 0.129 0.0785 1
Echinococcus granulosus poly ADP ribose polymerase 1 0.011 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Plasmodium falciparum cysteine proteinase falcipain 3 0.0222 0.0119 0.2736
Loa Loa (eye worm) hypothetical protein 0.0045 0.0009 0.0043
Plasmodium falciparum carbonic anhydrase 0.0699 0.0416 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1168 0.0708 0.1776
Leishmania major phosphatidylinositol 3-kinase, putative 0.1184 0.0718 0.1979
Loa Loa (eye worm) hypothetical protein 0.0063 0.002 0.0098
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.029 0.0161 0.0806
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0045 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Loa Loa (eye worm) endoplasmin 0.0103 0.0045 0.0224
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0449 0.026 0.0747
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0001 0.0003
Plasmodium falciparum serine repeat antigen 1 0.0045 0.0008 0.0037
Schistosoma mansoni heat shock protein 0.0042 0.0007 0.0015
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0222 0.0119 0.0593
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0387 0.0222 0.2944
Trypanosoma cruzi heat shock protein, putative 0.0042 0.0007 0.0019
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0196 0.0103 0.0294
Echinococcus granulosus cathepsin l1 0.015 0.0074 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Plasmodium vivax unspecified product 0.0045 0.0008 0.0098
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.0119 0.0296
Schistosoma mansoni endoplasmin 0.0103 0.0045 0.011
Trypanosoma brucei PAB1-binding protein , putative 0.0181 0.0093 0.1189
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.003 0.0029
Brugia malayi Putative carbonic anhydrase 5 precursor 0.129 0.0785 0.3919
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.029 0.0161 0.2118
Loa Loa (eye worm) hypothetical protein 0.0061 0.0019 0.0093
Brugia malayi fibroinase precursor 0.0045 0.0008 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0053 0.0674
Schistosoma mansoni endoplasmin 0.0103 0.0045 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) glutaminase 2 0.3243 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0082 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.024 0.013 0.0648
Brugia malayi Hsp90 protein 0.0042 0.0007 0.0033
Echinococcus multilocularis survival motor neuron protein 1 0.074 0.0441 0.0441
Echinococcus granulosus cathepsin l1 0.0222 0.0119 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0019 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0419 0.2073
Echinococcus multilocularis serine protein kinase ATM 0.0688 0.0409 0.0409
Schistosoma mansoni cathepsin C 0.0045 0.0008 0.0019
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0627 0.0371 0.1834
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0028 0.0139
Onchocerca volvulus 0.0151 0.0074 0.26
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0627 0.0371 0.1834
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0061 0.006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.129 0.0785 0.2255
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.029 0.0161 0.0783
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Echinococcus multilocularis smad 0.0102 0.0044 0.0043
Loa Loa (eye worm) heat shock protein 90 0.0103 0.0045 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.001 0.0023
Entamoeba histolytica protein kinase rad3, putative 0.0674 0.04 0.5396
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Echinococcus granulosus heat shock protein 0.0103 0.0045 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Schistosoma mansoni microtubule-associated protein tau 0.149 0.0909 0.228
Trypanosoma cruzi major cysteine proteinase, putative 0.0655 0.0389 0.1117
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0114 0.0051 0.0616
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0019 0.0045
Echinococcus granulosus geminin 0.0255 0.014 0.0139
Mycobacterium tuberculosis Conserved hypothetical protein 0.024 0.013 1
Plasmodium falciparum endoplasmin, putative 0.0063 0.002 0.0321
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0093 0.2119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni survival motor neuron protein 0.0151 0.0074 0.0185
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Loa Loa (eye worm) hypothetical protein 0.0674 0.04 0.2001
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0463
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0061 0.0306
Echinococcus multilocularis 0.024 0.013 0.0129
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0009 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.013 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0694 0.0413 0.2044
Toxoplasma gondii target of rapamycin (TOR), putative 0.1202 0.0729 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0053 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.0371 0.1854
Trypanosoma cruzi heat shock protein 90, putative 0.0082 0.0032 0.0091
Giardia lamblia Heat shock protein HSP 90-alpha 0.0082 0.0032 0.0321
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0688 0.0409 0.5218
Schistosoma mansoni hypothetical protein 0.024 0.013 0.0324
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.6425 0.3985 1
Trypanosoma cruzi cysteine peptidase, putative 0.0222 0.0119 0.0341
Plasmodium vivax endoplasmin, putative 0.0103 0.0045 0.2461
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0001 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0487 0.0284 0.1397
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Loa Loa (eye worm) hypothetical protein 0.006 0.0018 0.0089
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.045 0.0261 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.015 0.0074 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Brugia malayi latrophilin 2 splice variant baaae 0.0525 0.0308 0.1536
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0008 0.0007
Loa Loa (eye worm) MBCTL1 0.0051 0.0012 0.0062
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Toxoplasma gondii heat shock protein HSP90 0.0103 0.0045 0.0526
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0045 0.0008 0.0016
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0797 0.0477 0.0477
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0353 0.0201 0.0502
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0148 0.0072 0.5127
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0081 0.0201
Brugia malayi Bromodomain containing protein 0.0063 0.002 0.0097
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0045 0.0008 0.0098
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Onchocerca volvulus Cathepsin L homolog 0.0222 0.0119 0.4164
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.001 0.0023
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0092 0.0037 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.013 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.003 0.0086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0029 0.0302
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0008 0.0019
Toxoplasma gondii cathepsin B 0.0092 0.0037 0.0425
Entamoeba histolytica cysteine proteinase, putative 0.015 0.0074 0.092
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0008 0.0007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.0103 0.0255
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0083 0.0032 0.0161
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0045 0.0008 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi nuclear hormone receptor 0.0033 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus granulosus peregrin 0.0063 0.002 0.0019
Onchocerca volvulus 0.0222 0.0119 0.4164
Trypanosoma brucei Heat shock protein 83, putative 0.0103 0.0045 0.0569
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.003 0.0083
Echinococcus granulosus serine protein kinase ATM 0.0688 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0056 0.0015 0.0077
Loa Loa (eye worm) hypothetical protein 0.051 0.0298 0.1489
Trypanosoma brucei polo-like protein kinase 0.008 0.003 0.0382
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Echinococcus granulosus cathepsin b 0.0196 0.0103 0.0102
Schistosoma mansoni carbonic anhydrase-related 0.0699 0.0416 0.1042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.003 0.0029
Brugia malayi glutaminase DH11.1 0.3243 0.2002 1
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Giardia lamblia PHD finger protein 15 0.0063 0.002 0.0156
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.0181 0.0093 0.2119
Echinococcus granulosus cysteine protease 0.0117 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0045 0.0008 0.0016
Echinococcus multilocularis isocitrate dehydrogenase 0.0148 0.0072 0.0072
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0086 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Toxoplasma gondii hypothetical protein 0.0699 0.0416 0.5662
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Schistosoma mansoni jumonji domain containing protein 0.0164 0.0082 0.0205
Toxoplasma gondii cathepsin CPC2 0.0045 0.0008 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni myelin transcription factor 1 myt1 0.0051 0.0012 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Brugia malayi MH2 domain containing protein 0.0045 0.0009 0.0043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0222 0.0119 0.0593
Echinococcus granulosus cathepsin L 0.0045 0.0008 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0181 0.0093 0.5611
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0028 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.024 0.013 0.0324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2657
Echinococcus multilocularis heat shock protein 90 0.0082 0.0032 0.0031
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Echinococcus granulosus mothers against decapentaplegic 5 0.0102 0.0044 0.0043
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.002 0.0178
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.0119 0.0118
Brugia malayi Probable ClpP-like protease 0.0077 0.0029 0.0142
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.051 0.0298 0.0297
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.0053 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.008 0.003 0.0074
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0045 0.0008 0.0041
Leishmania major phosphatidylinositol 3-kinase, putative 0.029 0.0161 0.0444
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0001 0.0003
Echinococcus multilocularis cathepsin L 0.0117 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0081 0.0031 0.0076
Loa Loa (eye worm) ctsf protein 0.0222 0.0119 0.0593
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Trypanosoma cruzi heat shock protein 85, putative 0.0082 0.0032 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0025 0.0072
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Brugia malayi mbt repeat family protein 0.0045 0.0008 0.0041
Onchocerca volvulus 0.0045 0.0008 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0001 0.0004
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.024 0.013 0.7961
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0035 0.0034
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Brugia malayi Latrophilin receptor protein 2 0.0243 0.0132 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0009 0.0043
Schistosoma mansoni heat shock protein 0.0103 0.0045 0.011
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1213 0.0736 0.0736
Plasmodium falciparum phd finger protein, putative 0.0063 0.002 0.0314
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Leishmania major cathepsin L-like protease 0.0832 0.0499 0.1375
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0353 0.0201 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.011 0.0049 0.0048
Brugia malayi steroid hormone receptor 0.0033 0.0001 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0142
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0009 0.0278
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0768 0.0459 0.2293
Onchocerca volvulus 0.024 0.013 0.4556
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Plasmodium vivax vivapain-2 0.0222 0.0119 0.7244
Brugia malayi WGR domain containing protein 0.006 0.0018 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0688 0.0409 0.2045
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0045 0.0008 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0832 0.0499 0.1434
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.029 0.0161 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0434 0.0251 0.1232
Onchocerca volvulus 0.015 0.0074 0.2583
Plasmodium vivax hypothetical protein 0.024 0.013 0.7961
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0797 0.0477 0.0477
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0029 0.1411
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1233 0.0749 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.1213 0.0736 0.3664
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0045 0.0008 0.0098
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0148 0.0072 0.018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.045 0.0261 0.1303
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0043 0.0007 0.0036
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Onchocerca volvulus 0.0222 0.0119 0.4164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0029 0.1414
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Echinococcus multilocularis cathepsin L cysteine protease 0.0222 0.0119 0.0118
Giardia lamblia Grp94/Hsp90 0.0082 0.0032 0.0321
Trypanosoma cruzi cruzipain precursor, putative 0.0832 0.0499 0.1434
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0371 0.1067
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0025 0.0125
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0051 0.0012 0.0012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0208
Onchocerca volvulus 0.0487 0.0284 1
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Loa Loa (eye worm) heat shock protein 75 0.0042 0.0007 0.0034
Onchocerca volvulus 0.0222 0.0119 0.4164
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0008 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0001 0.0004
Plasmodium falciparum phosphatidylinositol 3-kinase 0.029 0.0161 0.3777
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0052 0.0013 0.003
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.029 0.0161 0.0783
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0008 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0063 0.002 0.0831
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0768 0.0459 0.2292
Loa Loa (eye worm) hypothetical protein 0.015 0.0074 0.0369
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0797 0.0477 0.1196
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0001 0.0003
Onchocerca volvulus Cathepsin F homolog 0.0222 0.0119 0.4164
Brugia malayi jmjC domain containing protein 0.0076 0.0028 0.0138
Brugia malayi MH2 domain containing protein 0.1491 0.091 0.4545
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0019 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1233 0.0749 0.2152
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0008 0.0098
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0117 0.0053 0.0152
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.051 0.0298 0.0297
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.024 0.013 0.0625
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Leishmania major phosphatidylinositol kinase related protein, putative 0.0254 0.0139 0.0382
Echinococcus multilocularis Smad4 0.0102 0.0044 0.0043
Echinococcus granulosus endoplasmin 0.0082 0.0032 0.0031
Toxoplasma gondii isocitrate dehydrogenase 0.0148 0.0072 0.0908
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0161 0.2138
Loa Loa (eye worm) MH1 domain-containing protein 0.0102 0.0044 0.0218
Leishmania major phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0357
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.024 0.013 0.3007
Brugia malayi hypothetical protein 0.0117 0.0053 0.0266
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.003 0.1035
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0093 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.1194 0.0725 0.3605
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0081 0.0031 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0008 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0001 0.0003
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0045 0.0008 0.0021
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.029 0.0161 0.2118
Echinococcus granulosus cathepsin L cysteine proteinase 0.0222 0.0119 0.0118
Trypanosoma cruzi heat shock protein 90, putative 0.0061 0.0018 0.0052
Schistosoma mansoni heat shock protein 0.0103 0.0045 0.011
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0045 0.0008 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0045 0.0008 0.0098
Trypanosoma brucei cysteine peptidase C (CPC) 0.0092 0.0037 0.0475
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0685 0.0407 0.5486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0001 0.0003
Loa Loa (eye worm) nuclear factor I 0.0056 0.0015 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Onchocerca volvulus 0.0222 0.0119 0.4164
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Brugia malayi FAT domain containing protein 0.051 0.0298 0.1488
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.024 0.013 0.1652
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1213 0.0736 0.2116
Brugia malayi Pre-SET motif family protein 0.0061 0.0019 0.0092
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0303 0.0169 0.2209
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0008 0.0008
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1213 0.0736 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) isocitrate dehydrogenase 0.0148 0.0072 0.0361
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0151 0.0074 0.0371
Echinococcus granulosus smad 0.0102 0.0044 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1233 0.0749 0.3742
Echinococcus multilocularis histone acetyltransferase MYST2 0.0051 0.0012 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0008 0.0264
Mycobacterium ulcerans glutaminase 0.3243 0.2002 1
Trypanosoma brucei heat shock protein 84, putative 0.0042 0.0007 0.0084
Schistosoma mansoni hypothetical protein 0.0151 0.0074 0.0185
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0627 0.0371 0.1834
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus multilocularis carbonic anhydrase 0.0699 0.0416 0.0415
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.024 0.013 0.1652
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1204 0.0731 0.9314
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0009 0.0008
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0029 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0008 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0001 0.0004
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0082 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0001 0.0003
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0045 0.0008 0.0098
Brugia malayi Isocitrate dehydrogenase 0.0148 0.0072 0.0361
Plasmodium vivax vivapain-1 0.0117 0.0053 0.2995
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.003 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0749 0.0447 0.2216
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0008 0.0008
Echinococcus granulosus GPCR family 2 0.0243 0.0132 0.0131
Trypanosoma cruzi PAB1-binding protein , putative 0.0181 0.0093 0.0268
Entamoeba histolytica cysteine proteinase 2 0.0117 0.0053 0.0634
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.129 0.0785 0.1967
Schistosoma mansoni carbonic anhydrase 0.0699 0.0416 0.1042
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0007 0.0009
Trichomonas vaginalis endoplasmin, putative 0.0063 0.002 0.0075
Trichomonas vaginalis glutaminase, putative 0.3243 0.2002 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0921
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0008 0.0016
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus multilocularis GPCR, family 2 0.0243 0.0132 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0181 0.0093 0.12
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Echinococcus multilocularis cathepsin b 0.0196 0.0103 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.0251 0.1232
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.003 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0001 0.0003
Echinococcus multilocularis cysteine protease 0.0222 0.0119 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Echinococcus granulosus cathepsin L cysteine protease 0.0117 0.0053 0.0052
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0051 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0148 0.0072 0.0072
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0035 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0092 0.0037 0.0163
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.024 0.013 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.0409 0.2026
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0258 0.0141 0.1796
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0353 0.0201 0.0576
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0045 0.0008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0077 0.0029 0.0143
Plasmodium falciparum serine repeat antigen 6 0.0045 0.0008 0.0037
Toxoplasma gondii FATC domain-containing protein 0.0688 0.0409 0.5573
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Trichomonas vaginalis heat shock protein, putative 0.0103 0.0045 0.0199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0008 0.0007
Brugia malayi ecdysteroid receptor 0.0033 0.0001 0.0003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0094 0.0093
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0463
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0008 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0243 0.0132 0.0131
Schistosoma mansoni smad1 5 8 and 0.0102 0.0044 0.0108
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.6075 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.024 0.013 0.0625
Brugia malayi N-terminal motif family protein 0.037 0.0211 0.1053
Plasmodium falciparum heat shock protein 90 0.0103 0.0045 0.0929
Echinococcus multilocularis Zinc finger, PHD finger 0.029 0.0161 0.0161
Schistosoma mansoni cathepsin s 0.0072 0.0025 0.0061
Schistosoma mansoni cathepsin F (C01 family) 0.015 0.0074 0.0184
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Brugia malayi cathepsin Z-like cysteine proteinase 0.0045 0.0008 0.0041
Schistosoma mansoni phosphatidylinositol 4-kinase 0.024 0.013 0.0324
Onchocerca volvulus Cathepsin L homolog 0.0222 0.0119 0.4164
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.0534
Loa Loa (eye worm) hypothetical protein 0.0749 0.0447 0.2235
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus multilocularis microtubule associated protein 2 0.149 0.0909 0.0908
Toxoplasma gondii cathepsin CPL 0.0222 0.0119 0.1549
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0081 0.0201
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0045 0.0008 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0102 0.0044 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0025 0.0072
Loa Loa (eye worm) phosphatidylinositol 3 0.1213 0.0736 0.3679
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.024 0.013 0.1702
Schistosoma mansoni poly [ADP-ribose] polymerase 0.011 0.0049 0.012
Brugia malayi cathepsin L-like precursor 0.015 0.0074 0.0369
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0045 0.0008 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0353 0.0201 0.1002
Schistosoma mansoni Smad4 0.0045 0.0009 0.002
Plasmodium falciparum serine repeat antigen 8 0.0045 0.0008 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.0119 0.1534
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0243 0.0132 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.053 0.0311 0.1532
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.129 0.0785 0.2255
Entamoeba histolytica hypothetical protein 0.0564 0.0332 0.4456
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Trypanosoma brucei heat shock protein 90, putative 0.0103 0.0045 0.0569
Loa Loa (eye worm) CYP4Cod1 0.0032 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0768 0.0459 0.2293
Trypanosoma brucei heat shock protein, putative 0.0103 0.0045 0.0569
Brugia malayi Smad1 0.0102 0.0044 0.0217
Schistosoma mansoni Smad4 0.0045 0.0009 0.002
Mycobacterium ulcerans heat shock protein 90 0.0082 0.0032 0.0157
Echinococcus granulosus WGR domain containing protein 0.0034 0.0002 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.008 0.003 0.0126
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.129 0.0785 0.392
Loa Loa (eye worm) hypothetical protein 0.0177 0.0091 0.0453
Loa Loa (eye worm) phosphatidylinositol 3 0.0114 0.0051 0.0256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0243 0.0132 0.0658
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Echinococcus granulosus heat shock protein 90 0.0103 0.0045 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0008 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0022 0.011
Schistosoma mansoni hypothetical protein 0.051 0.0298 0.0746
Loa Loa (eye worm) cysteine protease 0.0222 0.0119 0.0593
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0148 0.0072 0.1604
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0051 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0001 0.0004
Giardia lamblia Hypothetical protein 0.024 0.013 0.1669
Plasmodium falciparum serine repeat antigen 7 0.0045 0.0008 0.0037
Plasmodium vivax SET domain protein, putative 0.0061 0.0019 0.0767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Plasmodium vivax vivapain-2 0.0222 0.0119 0.7244
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.029 0.0161 0.0403
Loa Loa (eye worm) transcription factor SMAD2 0.1491 0.091 0.4545
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.0053 0.0634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0008 0.0016
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0148 0.0072 0.0921
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0009 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0148 0.0072 0.0908
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0148 0.0072 0.0208
Loa Loa (eye worm) hypothetical protein 0.0243 0.0132 0.0658
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0045 0.0008 0.0098
Brugia malayi cathepsin L-like cysteine proteinase 0.0045 0.0008 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0008 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.0053 0.0152
Treponema pallidum heat shock protein 90 0.0082 0.0032 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Loa Loa (eye worm) hypothetical protein 0.0108 0.0048 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Brugia malayi cathepsin B-like cysteine proteinase 0.0196 0.0103 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0255 0.014 0.0348
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0042 0.0007 0.0211
Plasmodium vivax heat shock protein 86, putative 0.0103 0.0045 0.2461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni cathepsin B (C01 family) 0.0045 0.0008 0.0019
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1213 0.0736 0.1846
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1213 0.0736 1
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Brugia malayi Cathepsin L-like precursor 0.0072 0.0025 0.0125
Plasmodium vivax unspecified product 0.0072 0.0025 0.1189
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0699 0.0416 0.2077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1213 0.0736 0.3679
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0061 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0008 0.0041
Entamoeba histolytica cysteine protease, putative 0.0045 0.0008 0.0021
Echinococcus multilocularis peregrin 0.0063 0.002 0.0019
Echinococcus granulosus carbonic anhydrase 0.0699 0.0416 0.0415
Echinococcus granulosus poly (ADP ribose) polymerase 0.0034 0.0002 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.1491 0.091 0.4545
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Loa Loa (eye worm) Smad1 0.0102 0.0044 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0006 0.0007
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0008 0.0039
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.002 0.0098
Brugia malayi hypothetical protein 0.0181 0.0093 0.0466
Echinococcus granulosus cathepsin L 0.0117 0.0053 0.0052
Giardia lamblia Cathepsin B precursor 0.0092 0.0037 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0009 0.0008
Giardia lamblia GTOR 0.1213 0.0736 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0028 0.0027
Plasmodium falciparum serine repeat antigen 3 0.0045 0.0008 0.0037
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.0053 0.0264
Schistosoma mansoni hypothetical protein 0.0063 0.002 0.0047
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0008 0.0039
Brugia malayi Cathepsin L-like cysteine proteinase 0.015 0.0074 0.0369
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Loa Loa (eye worm) hypothetical protein 0.0196 0.0103 0.0512
Schistosoma mansoni poly [ADP-ribose] polymerase 0.006 0.0018 0.0043
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0029 0.5
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0045 0.0008 0.0098
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Leishmania major cysteine peptidase A (CPA) 0.0222 0.0119 0.0327
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0196 0.0103 0.0255
Trypanosoma cruzi Heat shock protein 83, putative 0.0103 0.0045 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0674 0.04 0.2
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.024 0.013 0.0373
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0008 0.0023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0148 0.0072 0.0199
Loa Loa (eye worm) glutaminase 0.3243 0.2002 1
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0032 0.0134
Loa Loa (eye worm) hypothetical protein 0.045 0.0261 0.1304
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.029 0.0161 0.0161
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0082 0.0032 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0045 0.0008 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0001 0.0003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0373
Brugia malayi jmjC domain containing protein 0.0206 0.0109 0.0543
Entamoeba histolytica heat shock protein 90, putative 0.0103 0.0045 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.015 0.0074 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0001 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0017 0.0016
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0045 0.0008 0.0098
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Echinococcus granulosus heat shock protein 90 0.0082 0.0032 0.0031
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2657
Brugia malayi Papain family cysteine protease containing protein 0.0222 0.0119 0.0592
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Loa Loa (eye worm) carbonic anhydrase 3 0.129 0.0785 0.392
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1213 0.0736 0.9386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1194 0.0725 0.9236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0028 0.0068
Leishmania major heat shock protein, putative 0.0042 0.0007 0.0018
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0387 0.0222 0.2947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0692 0.0412 0.2037
Entamoeba histolytica cysteine proteinase, putative 0.0222 0.0119 0.1534
Echinococcus multilocularis carbonic anhydrase II 0.129 0.0785 0.0784
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0001 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0008 0.0007
Echinococcus multilocularis cathepsin L 0.0045 0.0008 0.0007
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0082 0.0032 0.167
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Leishmania major cathepsin L-like protease 0.0222 0.0119 0.0327
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0019 0.0045
Leishmania major carbonic anhydrase-like protein 0.129 0.0785 0.2162
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Loa Loa (eye worm) hypothetical protein 0.0699 0.0416 0.2078
Echinococcus multilocularis cathepsin b 0.0196 0.0103 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.0053 0.0241
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0222 0.0119 0.2736
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0029 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.04 0.1981
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0019 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0768 0.0459 0.2292
Entamoeba histolytica hypothetical protein 0.0688 0.0409 0.5519
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Plasmodium vivax serine-repeat antigen (SERA) 0.0045 0.0008 0.0098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0117 0.0053 0.0131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.024 0.013 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Onchocerca volvulus 0.0061 0.0019 0.063
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.024 0.013 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0028 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Leishmania major phosphatidylinositol kinase, putative 0.024 0.013 0.0357
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0222 0.0119 0.0118
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.029 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0129 0.0061 0.015
Loa Loa (eye worm) phosphatidylinositol kinase 0.024 0.013 0.0648
Toxoplasma gondii cathepsin CPC1 0.0045 0.0008 0.0021
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0758 0.0453 0.5773
Brugia malayi MH1 domain containing protein 0.0102 0.0044 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Loa Loa (eye worm) phosphatidylinositol 3 0.1194 0.0725 0.362
Trypanosoma cruzi cysteine proteinase, putative 0.0117 0.0053 0.0152
Schistosoma mansoni hypothetical protein 0.0243 0.0132 0.0329
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1184 0.0718 0.9152
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.0731 0.3635
Schistosoma mansoni smad 0.0045 0.0009 0.002
Brugia malayi MH2 domain containing protein 0.0102 0.0044 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.1193 0.0724 0.36
Trypanosoma cruzi hypothetical protein, conserved 0.5614 0.3479 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0045 0.0008 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0102 0.0044 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0222 0.0119 0.057
Loa Loa (eye worm) phosphatidylinositol 3 0.024 0.013 0.0648
Brugia malayi cathepsin L precursor 0.0045 0.0008 0.0041
Onchocerca volvulus 0.0222 0.0119 0.4164
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0627 0.0371 0.4995
Mycobacterium leprae conserved hypothetical protein 0.024 0.013 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0 0.0001
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.0725 0.3607
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.003 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0222 0.0119 0.057
Brugia malayi Cathepsin L-like precursor 0.0222 0.0119 0.0592
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0045 0.0008 0.0042
Schistosoma mansoni fkbp-rapamycin associated protein 0.0674 0.04 0.1003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0008 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0734 0.0438 0.2188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0001 0.0003
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0353 0.0201 0.2555
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.024 0.013 0.0129
Entamoeba histolytica cysteine protease, putative 0.0117 0.0053 0.0634
Loa Loa (eye worm) hypothetical protein 0.0072 0.0025 0.0125
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.029 0.0161 0.2054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0135 0.0653
Brugia malayi nuclear receptor NHR-88 0.0033 0.0001 0.0003
Brugia malayi heat shock protein 90 0.0103 0.0045 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.1202 0.0729 0.3628
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0008 0.0042
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.029 0.0161 0.0161
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0094 0.0093
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.029 0.0161 0.0783
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0761 0.0454 0.1306
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0627 0.0371 0.1067
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.029 0.0161 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1213 0.0736 0.2116
Trypanosoma cruzi heat shock protein 85, putative 0.0103 0.0045 0.0128
Leishmania major heat shock protein 83-1 0.0103 0.0045 0.0123
Brugia malayi WGR domain containing protein 0.011 0.0049 0.0242
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0012 0.0011
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0699 0.0416 0.2077
Loa Loa (eye worm) hypothetical protein 0.0222 0.0119 0.0593
Onchocerca volvulus 0.0222 0.0119 0.4164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1213 0.0736 0.2029
Onchocerca volvulus 0.0045 0.0008 0.0271
Loa Loa (eye worm) fibroinase 0.0222 0.0119 0.0593
Plasmodium falciparum serine repeat antigen 9 0.0045 0.0008 0.0037
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.002 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0243 0.0132 0.0658
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.0081 0.008
Brugia malayi isocitrate dehydrogenase 0.0148 0.0072 0.0361
Loa Loa (eye worm) hypothetical protein 0.0033 0.0001 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.053 0.0311 0.1532
Echinococcus granulosus microtubule associated protein 2 0.149 0.0909 0.0908
Entamoeba histolytica hypothetical protein 0.024 0.013 0.1686
Loa Loa (eye worm) hypothetical protein 0.037 0.0211 0.1053
Schistosoma mansoni hypothetical protein 0.0278 0.0154 0.0384
Schistosoma mansoni cathepsin F (C01 family) 0.0222 0.0119 0.0296
Schistosoma mansoni cathepsin S (C01 family) 0.0045 0.0008 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0832 0.0499 0.6362
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0008 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.1184 0.0718 0.3572
Brugia malayi Cytochrome P450 family protein 0.0067 0.0022 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0008 0.0018

Activities

Activity type Activity value Assay description Source Reference
Amount (functional) = 7.8 pM (10e6*cells)-1 Tested for intracellular levels of phosphoramidate against CEM cell lines. ChEMBL. 10841805
Amount (functional) = 120.7 pM (10e6*cells)-1 Tested for intracellular levels of AZT phosphate against CEM cell lines. ChEMBL. 10841805
Amount (functional) = 221 pM (10e6*cells)-1 Tested for intracellular levels of AZT phosphate against MCF-7 cell lines. ChEMBL. 10841805
Amount (functional) = 295 pM (10e6*cells)-1 Tested for intracellular levels of phosphoramidate against MCF-7 cell lines. ChEMBL. 10841805
CC50 (functional) = 0.4 uM In vitro cytotoxic concentration required to reduce MCF-7 cell growth by 50% ChEMBL. 10841805
Concentration (functional) = 0 pM (10e6*cells)-1 Intracellular of AZT-TP concentrations in LAI/HIV-1 infected PMBCs was determined at a conc of 10 microM) ChEMBL. 11170632
Concentration (functional) = 0.01 pM (10e6*cells)-1 Intracellular of AZT-TP concentrations in LAI/HIV-1 infected PMBCs was determined at a conc of 10 microM) ChEMBL. 11170632
Cytotoxicity (functional) = 0.4 uM Cytotoxic activity against MCF-7 cell lines. ChEMBL. 10841805
Cytotoxicity (functional) > 100 uM Cytotoxic activity against CEM cell lines. ChEMBL. 10841805
EC50 (functional) < 0.001 uM Effective concentration of required to inhibit the replication of HIV-1 BY 50% in CEM cells ChEMBL. 11170632
EC50 (functional) = 1 uM Effective concentration required to inhibit the replication of HIV-1 with 2 hr pretreatment of activated PBMCs ChEMBL. 11170632
EC50 (functional) = 15 uM Effective concentration of required to inhibit the replication of HIV-1 BY 50% in PMBCs from donor 2 ChEMBL. 11170632
EC50 (functional) = 15 uM Effective concentration required to inhibit the replication of HIV-1 with no pretreatment of activated PBMCs ChEMBL. 11170632
EC50 (functional) = 15 uM Effective concentration required to inhibit the replication of HIV-1 by 50% in PMBCs in the absence of thymidine ChEMBL. 11170632
EC50 (functional) = 25 uM Antiviral activity was determined in chronically infected U1 cell line with HIV-1 ChEMBL. 11170632
EC50 (functional) = 30 uM Effective concentration of required to inhibit the replication of HIV-1 BY 50% in PMBCs from donor 1 ChEMBL. 11170632
EC50 (functional) > 100 uM Effective concentration required to inhibit the replication of HIV-1 in activated PBMCs ChEMBL. 11170632
EC50 (functional) > 100 uM Effective concentration required to inhibit the replication of HIV-1 by 50% in PMBCs in the presence of thymidine ChEMBL. 11170632
IC100 (functional) > 100 uM Concentration required to kill 100% of unactivated PBMCs ChEMBL. 11170632
IC50 (functional) > 100 uM Concentration required to kill 50% of PBMCs ChEMBL. 11170632
IC50 (functional) > 100 uM Concentration required to kill 50% of CEM cells ChEMBL. 11170632

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11170632

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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