Detailed information for compound 1561288

Basic information

Technical information
  • TDR Targets ID: 1561288
  • Name: N-cyclohexyl-2-[[2-(4-fluorophenyl)-4-(4-meth ylphenyl)sulfonyl-1,3-oxazol-5-yl]sulfanyl]ac etamide
  • MW: 488.595 | Formula: C24H25FN2O4S2
  • H donors: 1 H acceptors: 4 LogP: 5.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCCC1)CSc1oc(nc1S(=O)(=O)c1ccc(cc1)C)c1ccc(cc1)F
  • InChi: 1S/C24H25FN2O4S2/c1-16-7-13-20(14-8-16)33(29,30)23-24(31-22(27-23)17-9-11-18(25)12-10-17)32-15-21(28)26-19-5-3-2-4-6-19/h7-14,19H,2-6,15H2,1H3,(H,26,28)
  • InChiKey: OFPRZQMMZNVISN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-2-[2-(4-fluorophenyl)-4-(4-methylphenyl)sulfonyl-oxazol-5-yl]sulfanyl-acetamide
  • N-cyclohexyl-2-[[2-(4-fluorophenyl)-4-(4-methylphenyl)sulfonyl-5-oxazolyl]thio]acetamide
  • N-cyclohexyl-2-[[2-(4-fluorophenyl)-4-(4-methylphenyl)sulfonyl-oxazol-5-yl]thio]acetamide
  • N-cyclohexyl-2-[[2-(4-fluorophenyl)-4-(4-methylphenyl)sulfonyl-1,3-oxazol-5-yl]sulfanyl]ethanamide
  • C176-0181
  • NCGC00104512-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0009 0.002 0.006
Onchocerca volvulus 0.0008 0.0006 0.0019
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0006 0.0022
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0009 0.002 0.0069
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0399 0.504
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0134 0.0449
Toxoplasma gondii facilitative glucose transporter GT1 0.0009 0.002 0.0204
Schistosoma mansoni hypothetical protein 0.0011 0.0031 0.0031
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0546 0.0546
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0754 0.2525
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0019 0.0012
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0271 0.0265
Schistosoma mansoni zinc finger protein 0.0025 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0201 0.0462
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0167 0.2347
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0102 0.0096
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0754 0.1556
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0118 0.055
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0035 0.0067
Leishmania major basic transcription factor 3a, putative 0.0034 0.0201 0.2491
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0399 0.1941
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0131 0.1663
Onchocerca volvulus 0.0008 0.0006 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0201 0.0462
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0132
Brugia malayi hypothetical protein 0.0016 0.0067 0.0224
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus granulosus solute carrier family 22 0.0009 0.002 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0131 0.6401
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0495 0.0489
Echinococcus multilocularis lamin 0.0026 0.0144 0.0137
Echinococcus granulosus solute carrier family 22 0.0009 0.002 0.0014
Trypanosoma brucei THT1 - hexose transporter, putative 0.0009 0.002 0.0187
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0015 0.013
Brugia malayi intermediate filament protein 0.0026 0.0144 0.0481
Onchocerca volvulus 0.0026 0.0144 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Leishmania major glucose transporter/membrane transporter D2, putative 0.0009 0.002 0.018
Trypanosoma cruzi hexose transporter, putative 0.0009 0.002 0.0187
Brugia malayi hypothetical protein 0.0008 0.0006 0.0022
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0281 0.2029 1
Echinococcus granulosus solute carrier family 22 0.0009 0.002 0.0014
Echinococcus multilocularis lamin dm0 0.0026 0.0144 0.0137
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Trypanosoma cruzi ISWI complex protein 0.0018 0.0087 0.1075
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0144
Echinococcus multilocularis cpg binding protein 0.0033 0.0192 0.0185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0019 0.0019
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.0692 0.917
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0144 0.0479
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0167 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0281 0.2029 1
Trypanosoma cruzi hexose transporter, putative 0.0009 0.002 0.0187
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Loa Loa (eye worm) POT family protein 0.0079 0.0535 0.1792
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0048 0.0161
Onchocerca volvulus 0.0009 0.002 0.006
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0118 0.1623
Loa Loa (eye worm) hypothetical protein 0.0017 0.0076 0.0253
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0389 0.0389
Echinococcus multilocularis zinc finger protein 0.0025 0.0137 0.0131
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0754 0.1779
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0754 0.9592
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0009 0.002 0.1258
Echinococcus granulosus transcription factor btf3 0.0034 0.0201 0.0194
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0006 0.0019
Plasmodium vivax hexose transporter 0.0009 0.002 0.0365
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0399 0.573
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0201 0.0462
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0006 0.002
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Brugia malayi MAP kinase sur-1 0.01 0.0692 0.2319
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0167 0.2347
Onchocerca volvulus 0.0008 0.0006 0.0019
Brugia malayi hypothetical protein 0.0009 0.002 0.0069
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.0692 0.8796
Brugia malayi hypothetical protein 0.0024 0.0131 0.0438
Schistosoma mansoni intermediate filament proteins 0.0026 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) major facilitator superfamily transporter 0.0009 0.002 0.0067
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0576 0.4207 1
Onchocerca volvulus 0.0009 0.002 0.006
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0542 0.0542
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0089 0.4243
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Brugia malayi major facilitator superfamily protein 0.0009 0.002 0.0069
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0167 0.4202
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0692 0.917
Onchocerca volvulus 0.0009 0.002 0.006
Schistosoma mansoni sugar transporter 0.0009 0.002 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Trypanosoma cruzi hexose transporter, putative 0.0009 0.002 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0131 0.1663
Schistosoma mansoni bromodomain containing protein 0.0078 0.0527 0.0527
Onchocerca volvulus 0.0009 0.002 0.006
Trichomonas vaginalis glucose transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus Sugar transporter ERD6 protein 0.0009 0.002 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trypanosoma brucei glucose transporter 2A 0.0009 0.002 0.0187
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Brugia malayi POT family protein 0.0079 0.0535 0.1793
Schistosoma mansoni hypothetical protein 0.0009 0.002 0.002
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) sugar transporter 0.0009 0.002 0.0067
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0009 0.002 0.0069
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.008 0.0542 0.1814
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0754 1
Brugia malayi 6-phosphofructokinase 0.0109 0.0754 0.2526
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0035 0.0375
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0102 0.0102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0786 0.3852
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0131 0.1813
Echinococcus granulosus Solute carrier family 22 5 0.1004 0.7372 0.737
Brugia malayi Major Facilitator Superfamily protein 0.0009 0.002 0.0069
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.0692 0.0686
Brugia malayi Pre-SET motif family protein 0.041 0.2984 1
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0041 0.0464
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0201 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0118 0.2905
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0399 0.1941
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0118 0.1427
Brugia malayi hypothetical protein 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0041 0.0136
Onchocerca volvulus 0.0009 0.002 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Echinococcus granulosus intermediate filament protein 0.0026 0.0144 0.0137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0015 0.013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Onchocerca volvulus 0.0009 0.002 0.006
Brugia malayi phosphofructokinase 0.0109 0.0754 0.2526
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0576 0.4207 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0009 0.002 0.0187
Plasmodium falciparum hexose transporter 0.0009 0.002 0.0721
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0201 0.0462
Trichomonas vaginalis myo-inositol transporter, putative 0.0009 0.002 0.0033
Schistosoma mansoni glucose transport protein 0.0009 0.002 0.002
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trichomonas vaginalis glucose transporter, putative 0.0009 0.002 0.0033
Leishmania major hypothetical protein, conserved 0.0009 0.0017 0.014
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0009 0.002 0.0721
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0108 0.036
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0754 0.0748
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0167 0.0383
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0035 0.0375
Schistosoma mansoni cpg binding protein 0.0033 0.0192 0.0192
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0754 0.1779
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0015 0.0009
Trichomonas vaginalis sugar transport protein, putative 0.0009 0.002 0.0033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0031 0.0025
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0035 0.036
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0118 0.055
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0692 0.1632
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0017 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0167 0.4202
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.0692 0.917
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0041 0.0136
Echinococcus granulosus geminin 0.0164 0.1165 0.1159
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0015 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0044 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Brugia malayi beta-NAC-like protein 0.0034 0.0201 0.0672
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.0692 0.917
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0009 0.002 0.006
Trypanosoma cruzi glucose transporter, putative 0.0009 0.002 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0032 0.0105
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0006 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Onchocerca volvulus 0.0009 0.002 0.006
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0041 0.0464
Schistosoma mansoni glucose transporter 0.0009 0.002 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0144 0.0481
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0015 0.0021
Plasmodium vivax sugar transporter, putative 0.0009 0.002 0.0365
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0056 0.0717
Brugia malayi CXXC zinc finger family protein 0.0029 0.0163 0.0545
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0131 0.6401
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0754 0.1779
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0754 0.3695
Trypanosoma brucei glucose transporter 1E 0.0009 0.002 0.0187
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0271 0.0265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0049
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0692 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0389 0.0389
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0108 0.0242
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0754 0.3695
Schistosoma mansoni bromodomain containing protein 0.0007 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0399 0.0399
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0201 0.2597
Schistosoma mansoni zinc finger protein 0.0018 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0008 0.0006 0.0019
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Onchocerca volvulus 0.0081 0.0546 0.1604
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Schistosoma mansoni sugar transporter 0.0009 0.002 0.002
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0754 0.0754
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0044 0.0037
Leishmania major myo-inositol/proton symporter (MIT) 0.0009 0.002 0.018
Schistosoma mansoni DNA helicase recq5 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus solute carrier family 22 0.0009 0.002 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0417 0.0417
Schistosoma mansoni sugar transporter 0.0009 0.002 0.002
Trypanosoma brucei THT1 - hexose transporter, putative 0.0009 0.002 0.0187
Schistosoma mansoni glucose transport protein 0.0009 0.002 0.002
Echinococcus multilocularis transcription factor btf3 0.0034 0.0201 0.0194
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0131 0.0436
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0495 0.0489
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 0.0786 0.0786
Brugia malayi Sugar transporter family protein 0.0009 0.002 0.0069
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0167 0.8287
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0167 0.0121
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0164 0.0157
Onchocerca volvulus 0.0008 0.0006 0.0019
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0786 0.2633
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0369 0.0362
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0035 0.0067
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni lamin 0.0026 0.0144 0.0144
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0019 0.0012
Echinococcus granulosus zinc finger protein 0.0025 0.0137 0.0131
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0057 0.1317
Giardia lamblia Sugar-proton symporter 0.0009 0.002 0.0033
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0118 0.055
Onchocerca volvulus 0.0009 0.002 0.006
Toxoplasma gondii transporter, major facilitator family protein 0.0009 0.002 0.0204
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0118 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0201 0.2832
Schistosoma mansoni sugar transporter 0.0009 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0025 0.0134 0.0134
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0054 0.0179
Brugia malayi hypothetical protein 0.0009 0.002 0.0069
Brugia malayi oxidoreductase 0.0008 0.0006 0.0022
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0032 0.0025
Loa Loa (eye worm) RecQ helicase 0.0021 0.0108 0.036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0006 0.0022
Loa Loa (eye worm) major facilitator superfamily transporter 0.0009 0.002 0.0067
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.0786 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0144 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0692 0.1632
Onchocerca volvulus 0.0008 0.0006 0.0019
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0006 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.1359 1 1
Trichomonas vaginalis glucose transporter, putative 0.0009 0.002 0.0033
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0015 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0754 0.1779
Onchocerca volvulus 0.0008 0.0006 0.0019
Echinococcus multilocularis geminin 0.0164 0.1165 0.1159
Brugia malayi Sugar transporter family protein 0.0009 0.002 0.0069
Brugia malayi Pre-SET motif family protein 0.0059 0.0389 0.1305
Brugia malayi Cytochrome P450 family protein 0.0012 0.0041 0.0138
Toxoplasma gondii sugar transporter ST3 0.0009 0.002 0.0204
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0009 0.002 0.0014
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0102 0.0096
Leishmania major glucose transporter, lmgt3 0.0009 0.002 0.018
Brugia malayi PHD-finger family protein 0.0032 0.0185 0.0619
Giardia lamblia Fructose-bisphosphate aldolase 0.0576 0.4207 1
Onchocerca volvulus 0.0467 0.3403 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0546 0.0539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.008 0.0542 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0167 0.8287
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0468
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0006 0.0006
Brugia malayi 6-phosphofructokinase 0.0109 0.0754 0.2526
Loa Loa (eye worm) sugar transporter 0.0009 0.002 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0118 0.055
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0075 0.0075
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0006 0.0022
Brugia malayi Bromodomain containing protein 0.0046 0.0292 0.0979
Onchocerca volvulus 0.0009 0.002 0.006
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0201 0.507
Echinococcus multilocularis synaptic vesicle 2 protein 0.0009 0.002 0.0014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0399 0.1941
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0754 0.2525
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Trypanosoma cruzi sugar transporter, putative 0.0009 0.002 0.0187
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0054 0.018
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0167 0.0383
Loa Loa (eye worm) dehydrogenase 0.0008 0.0006 0.002
Echinococcus granulosus lamin dm0 0.0026 0.0144 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.039 0.559
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.0692 0.917
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0754 0.2525
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0041 0.0172
Entamoeba histolytica hypothetical protein 0.0023 0.0118 0.0265
Trypanosoma brucei protein kinase, putative 0.01 0.0692 0.917
Toxoplasma gondii sugar transporter ST2 0.0009 0.002 0.0204
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0164 0.0164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0399 0.1941
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.2984 1
Onchocerca volvulus 0.0008 0.0006 0.0019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0032 0.0025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0041 0.0136
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0754 0.1779
Loa Loa (eye worm) hypothetical protein 0.0046 0.0293 0.098
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0399 0.0393
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Brugia malayi Major Facilitator Superfamily protein 0.0009 0.002 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0017 0.0146
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0009 0.002 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0041 0.0464
Brugia malayi hypothetical protein 0.0009 0.002 0.0069
Giardia lamblia Hexose transporter 0.0009 0.002 0.0033
Onchocerca volvulus Sepiapterin reductase homolog 0.0008 0.0006 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0692 0.1632
Echinococcus multilocularis microtubule associated protein 2 0.1359 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0754 0.1779
Trypanosoma cruzi hexose transporter 0.0009 0.002 0.0187
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Brugia malayi Major Facilitator Superfamily protein 0.0009 0.002 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Schistosoma mansoni hypothetical protein 0.0018 0.0087 0.0087
Onchocerca volvulus 0.0009 0.002 0.006
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0108 0.0362
Onchocerca volvulus 0.0026 0.0144 0.0422
Echinococcus granulosus histone lysine methyltransferase setb 0.008 0.0542 0.0535
Onchocerca volvulus 0.0059 0.0389 0.1144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.008 0.0542 0.0535
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0201 0.2597
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0118 0.1623
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi major facilitator superfamily protein 0.0009 0.002 0.0069
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0754 0.0754
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0786 0.078
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0009 0.002 0.002
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Trypanosoma cruzi hexose transporter, putative 0.0009 0.002 0.0187
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.0692 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0006 0.0006
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0131 0.3245
Mycobacterium ulcerans integral membrane transport protein 0.0009 0.002 0.0069
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0006 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0108 0.0242
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Leishmania major glucose transporter, lmgt2 0.0009 0.002 0.018
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0015 0.0009
Trypanosoma brucei THT1 - hexose transporter, putative 0.0009 0.002 0.0187
Onchocerca volvulus 0.0009 0.002 0.006
Leishmania major glucose transporter, lmgt1 0.0009 0.002 0.018
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0015 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0015 0.005
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0399 0.0399
Onchocerca volvulus 0.0008 0.0006 0.0019
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.0729 0.2443
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0015 0.0009
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Echinococcus multilocularis musashi 0.0026 0.0144 0.0137
Schistosoma mansoni hypothetical protein 0.0164 0.1165 0.1165
Mycobacterium ulcerans sugar transporter 0.0009 0.002 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0389 0.5586
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0281 0.2029 1
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.0692 0.2317
Onchocerca volvulus 0.0009 0.002 0.006
Echinococcus multilocularis solute carrier family 22 0.0009 0.002 0.0014
Toxoplasma gondii sugar transporter ST1 0.0009 0.002 0.0204
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0012
Entamoeba histolytica hypothetical protein 0.0034 0.0201 0.0462
Onchocerca volvulus 0.0008 0.0006 0.0019
Echinococcus granulosus bloom syndrome protein 0.0021 0.0108 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Brugia malayi Sugar transporter family protein 0.0009 0.002 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Loa Loa (eye worm) dehydrogenase 0.0008 0.0006 0.002
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Onchocerca volvulus 0.0008 0.0006 0.0019
Schistosoma mansoni glucose transport protein 0.0009 0.002 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0786 0.3852
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Plasmodium vivax SET domain protein, putative 0.0059 0.0389 1
Onchocerca volvulus 0.0009 0.002 0.006
Echinococcus multilocularis solute carrier family 22 0.0009 0.002 0.0014
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0754 0.0748
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0009 0.002 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0754 0.1779
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0786 0.3852
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Leishmania major cytochrome p450-like protein 0.0012 0.0041 0.0445
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0006 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Onchocerca volvulus 0.0008 0.0006 0.0019
Echinococcus granulosus cpg binding protein 0.0033 0.0192 0.0185
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0108 0.0102
Leishmania major hypothetical protein, conserved 0.0024 0.0131 0.1595
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Onchocerca volvulus Putative transporter 0.0009 0.002 0.006
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0118 0.5729
Schistosoma mansoni cpg binding protein 0.0029 0.0163 0.0163
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0546 0.0539
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0467 0.3403 0.8085
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Schistosoma mansoni carbonyl reductase 0.0008 0.0006 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0118 0.1488
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0009 0.002 0.0069
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0786 0.078
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.0692 0.0686
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0163 0.0543
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0006 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus lamin 0.0026 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0144 0.0479
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0164 0.0157
Trypanosoma brucei ISWI complex protein 0.0018 0.0087 0.1075
Leishmania major hypothetical protein, conserved 0.0018 0.0087 0.1031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Schistosoma mansoni transcription factor btf3 0.0034 0.0201 0.0201
Trypanosoma brucei sugar transporter, putative 0.0009 0.002 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0389 0.0383
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Brugia malayi Bromodomain containing protein 0.0092 0.0632 0.2118
Onchocerca volvulus 0.0029 0.0163 0.0478
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0399 0.0393
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0031 0.0025
Onchocerca volvulus 0.0009 0.002 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.005
Giardia lamblia Kinase, CMGC MAPK 0.01 0.0692 0.1632
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0015 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus granulosus mitogen activated protein kinase 0.01 0.0692 0.0686
Loa Loa (eye worm) hypothetical protein 0.0085 0.0582 0.1948
Schistosoma mansoni hypothetical protein 0.0164 0.1165 0.1165
Loa Loa (eye worm) hypothetical protein 0.0081 0.0546 0.1827
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0754 0.3695
Echinococcus multilocularis solute carrier family 22 0.0009 0.002 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0131 0.1663
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Loa Loa (eye worm) hypothetical protein 0.0049 0.0314 0.105
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0053 0.0343 0.1148
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Schistosoma mansoni lamin 0.0026 0.0144 0.0144
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0546 0.1828
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0167 0.2347
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.002 0.0033
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0167 0.0383
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.0692 0.0686
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0754 1
Schistosoma mansoni cpg binding protein 0.0033 0.0192 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0167 0.0383
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Loa Loa (eye worm) hypothetical protein 0.0009 0.002 0.0067
Schistosoma mansoni DNA helicase recq1 0.0009 0.0015 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0012
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Leishmania major hypothetical protein, conserved 0.0009 0.002 0.018
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.002
Trypanosoma brucei glucose transporter, putative 0.0009 0.002 0.0187
Trypanosoma cruzi ISWI complex protein 0.0018 0.0087 0.1075
Trichomonas vaginalis sugar transporter, putative 0.0009 0.002 0.0033
Echinococcus multilocularis solute carrier family 22 0.0009 0.002 0.0014
Brugia malayi Cytochrome P450 family protein 0.0012 0.0041 0.0138
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.0692 0.8796
Echinococcus granulosus synaptic vesicle 2 protein 0.0009 0.002 0.0014
Treponema pallidum fructose-bisphosphate aldolase 0.0576 0.4207 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0009 0.002 0.0014
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0006 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0006 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0022
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0576 0.4207 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0201 0.2597

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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