Detailed information for compound 165326

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.467 | Formula: C25H23N3O5
  • H donors: 3 H acceptors: 4 LogP: 2.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@H]1C(=O)N2[C@@H]1CC(=C2C(=O)O)c1cc(C2=NCCCN2)c2c(c1)c1ccccc1o2)O
  • InChi: 1S/C25H23N3O5/c1-12(29)20-18-11-15(21(25(31)32)28(18)24(20)30)13-9-16-14-5-2-3-6-19(14)33-22(16)17(10-13)23-26-7-4-8-27-23/h2-3,5-6,9-10,12,18,20,29H,4,7-8,11H2,1H3,(H,26,27)(H,31,32)/t12-,18-,20-/m1/s1
  • InChiKey: NRQIUWGXTMAXAB-ZQBYOIRZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis endonuclease IV 0.0074 0.0796 1
Echinococcus granulosus neuropeptide s receptor 0.0453 0.5682 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0041 0.004
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Schistosoma mansoni flap endonuclease-1 0.0023 0.0131 0.0287
Schistosoma mansoni thyroid hormone receptor 0.0216 0.263 0.6375
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0195 0.0441
Onchocerca volvulus 0.0035 0.0287 0.0458
Brugia malayi hypothetical protein 0.0044 0.0409 0.0925
Trypanosoma brucei trypanothione reductase 0.0046 0.0428 0.1146
Loa Loa (eye worm) tubulin alpha chain 0.0241 0.2949 0.6667
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0476 0.1271
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0478 0.1081
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1198 0.3162
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1198 0.2887
Echinococcus multilocularis Tubulin beta 2C chain 0.0294 0.3635 0.3635
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0094 0.1052 0.1051
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0204 0.0453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Brugia malayi cytochrome P450 0.0014 0.0013 0.0029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0041 0.0077
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0235 0.0612
Onchocerca volvulus 0.0026 0.0173 0.0197
Echinococcus multilocularis peroxisome assembly protein 26 0.0241 0.2949 0.2949
Trypanosoma brucei epsilon tubulin 0.0177 0.2123 0.5824
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0071 0.0385
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0294 0.3635 0.3635
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0071 0.0262
Echinococcus granulosus transcription factor eb 0.0105 0.1188 0.2091
Echinococcus granulosus tubulin subunit beta 0.0294 0.3635 0.6398
Mycobacterium ulcerans beta-lactamase 0.0035 0.0287 0.2311
Echinococcus granulosus Tubulin beta 2C chain 0.0294 0.3635 0.6398
Trichomonas vaginalis tubulin epsilon chain, putative 0.0294 0.3635 1
Leishmania major beta tubulin 0.0294 0.3635 1
Schistosoma mansoni retinoic acid receptor RXR 0.019 0.2287 0.5541
Echinococcus granulosus cpg binding protein 0.0029 0.0216 0.0379
Trichomonas vaginalis tubulin alpha chain, putative 0.0294 0.3635 1
Leishmania major epsilon tubulin, putative 0.0177 0.2123 0.5824
Loa Loa (eye worm) steroid hormone receptor 0.0094 0.1052 0.2377
Trypanosoma brucei epsilon tubulin 0.0177 0.2123 0.5824
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0491 0.111
Echinococcus granulosus tubulin beta 1 chain 0.0294 0.3635 0.6398
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0041 0.0068
Loa Loa (eye worm) glutathione reductase 0.0046 0.0428 0.0967
Echinococcus granulosus tubulin alpha 0.0177 0.2123 0.3735
Onchocerca volvulus 0.0044 0.0409 0.0741
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0287 0.0648
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.0161
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0287 0.0286
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0123 0.0276
Echinococcus multilocularis tubulin alpha chain 0.0241 0.2949 0.2949
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0287 0.0286
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0235 0.0539
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0235 0.053
Brugia malayi tailless protein 0.0044 0.0409 0.0925
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1413 0.2487
Echinococcus granulosus single minded 2 0.0035 0.0287 0.0504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0409 0.0719
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0235 0.0612
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.1198 0.3272
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.1052 0.2378
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.0382
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1413 0.1413
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0828 0.2252
Schistosoma mansoni hypothetical protein 0.0066 0.0691 0.1652
Echinococcus multilocularis tubulin alpha 1C chain 0.0241 0.2949 0.2949
Loa Loa (eye worm) hypothetical protein 0.0158 0.1881 0.4253
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0162 0.0337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Entamoeba histolytica tubulin family protein 0.0294 0.3635 1
Trypanosoma brucei alpha tubulin 0.0241 0.2949 0.8105
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0362 0.0956
Onchocerca volvulus 0.0035 0.0287 0.0458
Brugia malayi nuclear receptor NHR-88 0.0044 0.0409 0.0925
Plasmodium vivax tubulin alpha chain, putative 0.0241 0.2949 0.8091
Leishmania major beta tubulin 0.0294 0.3635 1
Brugia malayi Tubulin alpha chain 0.0241 0.2949 0.6668
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0709 0.1914
Trypanosoma brucei beta tubulin 0.0177 0.2123 0.5824
Trypanosoma brucei zeta tubulin 0.0077 0.0828 0.2252
Loa Loa (eye worm) hypothetical protein 0.0048 0.0455 0.1029
Loa Loa (eye worm) tubulin alpha 2 0.0064 0.0662 0.1495
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2798 0.6327
Toxoplasma gondii ABC1 family protein 0.0035 0.0287 0.0756
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1187 0.4341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Giardia lamblia Delta tubulin 0.0077 0.0828 0.2191
Brugia malayi thymidylate synthase 0.0104 0.1182 0.2673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0094 0.1052 0.2377
Entamoeba histolytica hypothetical protein 0.007 0.0745 0.189
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.1732 0.4704
Echinococcus multilocularis beta tubulin 0.0294 0.3635 0.3635
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.0308
Brugia malayi Pax transcription factor protein 2 0.0234 0.2852 0.6449
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0478 0.084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0613 0.1461
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1708 0.1707
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0287 0.1012
Echinococcus multilocularis hypothetical protein 0.0241 0.2949 0.2949
Loa Loa (eye worm) tubulin beta-1 chain 0.0294 0.3635 0.8219
Schistosoma mansoni alpha tubulin 0.0241 0.2949 0.7152
Plasmodium vivax tubulin gamma chain, putative 0.0177 0.2123 0.5792
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1674 0.4048
Trichomonas vaginalis tubulin beta chain, putative 0.01 0.113 0.3076
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0071 0.0071
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Echinococcus multilocularis tubulin alpha 0.0177 0.2123 0.2122
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1187 0.4341
Schistosoma mansoni smad1 5 8 and 0.0016 0.0041 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0409 0.0965
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1338 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.108
Trichomonas vaginalis tubulin epsilon chain, putative 0.0241 0.2949 0.8104
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.0748
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Onchocerca volvulus 0.0234 0.2852 0.6377
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1674 0.1674
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0041 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.0161
Brugia malayi Cell division protein ftsZ 0.0077 0.0828 0.1873
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0094 0.1052 0.2377
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.0409 0.0924
Trichomonas vaginalis tubulin alpha chain, putative 0.0177 0.2123 0.582
Trichomonas vaginalis tubulin epsilon chain, putative 0.0294 0.3635 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0217 0.0498
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0385 0.1374
Trypanosoma brucei alpha tubulin 0.0241 0.2949 0.8105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0094 0.1052 0.253
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.1198 0.8941
Leishmania major beta tubulin 0.0294 0.3635 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0235 0.0612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2452 0.5544
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.2123 0.5824
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.0648
Echinococcus multilocularis transcription factor eb 0.0105 0.1188 0.1188
Leishmania major beta tubulin 0.0294 0.3635 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0041 0.0236
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0104 0.1182 0.2671
Echinococcus multilocularis chromobox protein 1 0.0068 0.0709 0.0708
Mycobacterium leprae cell division protein FtsZ 0.0077 0.0828 0.6153
Trypanosoma cruzi beta tubulin, putative 0.0294 0.3635 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0041 0.0077
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0162 0.0365
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.0409 0.0925
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0287 0.2311
Onchocerca volvulus Protein ultraspiracle homolog 0.0094 0.1052 0.2223
Brugia malayi ecdysteroid receptor 0.0094 0.1052 0.2378
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1187 0.8862
Trichomonas vaginalis tubulin, putative 0.01 0.113 0.3076
Echinococcus granulosus lamin 0.0026 0.0173 0.0304
Brugia malayi hypothetical protein 0.0044 0.0409 0.0925
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0455 0.1078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0094 0.1052 0.2377
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0017 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0409 0.0924
Brugia malayi TAZ zinc finger family protein 0.0102 0.115 0.2601
Loa Loa (eye worm) p25-alpha family protein 0.0355 0.4423 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0287 0.2311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.1052 0.2378
Schistosoma mansoni tubulin subunit delta 0.0077 0.0828 0.1987
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1198 0.3162
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0162 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.0748
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.113 0.3076
Brugia malayi nuclear receptor RXR 0.005 0.0478 0.1081
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.0409 0.0965
Echinococcus multilocularis tubulin subunit beta 0.0294 0.3635 0.3635
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.1956 0.4422
Brugia malayi MH1 domain containing protein 0.0016 0.0041 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0123 0.0276
Leishmania major beta tubulin 0.0294 0.3635 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Loa Loa (eye worm) hypothetical protein 0.0046 0.0432 0.0976
Plasmodium vivax tubulin alpha chain, putative 0.0241 0.2949 0.8091
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0204 0.0518
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0094 0.1052 0.1051
Entamoeba histolytica hypothetical protein 0.007 0.0745 0.189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0409 0.0408
Loa Loa (eye worm) phosphofructokinase 0.0105 0.1198 0.2708
Leishmania major beta tubulin 0.0294 0.3635 1
Trypanosoma brucei epsilon tubulin 0.0177 0.2123 0.5824
Brugia malayi Tubulin alpha-2 chain 0.0241 0.2949 0.6668
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0123 0.0303
Echinococcus multilocularis tubulin alpha 1C chain 0.0241 0.2949 0.2949
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0287 0.1012
Brugia malayi hypothetical protein 0.005 0.0476 0.1077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.1052 0.1051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.019 0.2287 0.4025
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0287 0.0684
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1187 0.4341
Brugia malayi beta-tubulin, identical 0.0294 0.3635 0.8219
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0385 0.0869
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0452 0.1069
Echinococcus multilocularis tubulin epsilon chain 0.0177 0.2123 0.2122
Echinococcus multilocularis jun protein 0.0081 0.0888 0.0888
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.2853 0.645
Echinococcus granulosus thymidylate synthase 0.0104 0.1182 0.208
Mycobacterium leprae Probable lipase LipE 0.0035 0.0287 0.2066
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0287 0.0648
Giardia lamblia Beta tubulin 0.0294 0.3635 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0195 0.0442
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0409 0.0719
Schistosoma mansoni smad1 5 8 and 0.0016 0.0041 0.0069
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Onchocerca volvulus 0.01 0.113 0.2403
Echinococcus granulosus Smad4 0.0016 0.0041 0.0071
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.0152
Onchocerca volvulus 0.0048 0.0455 0.0847
Treponema pallidum cell division protein FtsZ 0.0077 0.0828 0.6807
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0094 0.1052 0.185
Trichomonas vaginalis tubulin epsilon chain, putative 0.0241 0.2949 0.8104
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 0.0756
Brugia malayi Dihydrofolate reductase 0.0043 0.0385 0.087
Echinococcus granulosus tubulin alpha chain 0.0241 0.2949 0.519
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0409 0.0925
Echinococcus granulosus Tubulin alpha 1 chain 0.0241 0.2949 0.519
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0745 0.1783
Mycobacterium ulcerans epimerase 0.002 0.0088 0.0635
Trichomonas vaginalis tubulin, putative 0.01 0.113 0.3076
Brugia malayi steroid hormone receptor 0.0094 0.1052 0.2378
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Echinococcus multilocularis Tubulin beta 2C chain 0.0294 0.3635 0.3635
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0077 0.0828 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0041 0.0068
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0102 0.115 0.2771
Brugia malayi bZIP transcription factor family protein 0.0081 0.0888 0.2008
Leishmania major beta tubulin 0.0294 0.3635 1
Loa Loa (eye worm) cytochrome P450 0.0014 0.0013 0.0028
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1198 0.3265
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0428 0.1146
Loa Loa (eye worm) hypothetical protein 0.0024 0.0151 0.0341
Trichomonas vaginalis tubulin, putative 0.0077 0.0828 0.2245
Trypanosoma brucei tubulin gamma chain 0.0177 0.2123 0.5824
Onchocerca volvulus 0.0104 0.1182 0.2524
Leishmania major beta tubulin 0.0294 0.3635 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0041 0.0077
Schistosoma mansoni lamin 0.0026 0.0173 0.0391
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0476 0.1712
Entamoeba histolytica tubulin alpha-1 chain 0.0241 0.2949 0.8074
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1338 0.4898
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0287 0.0756
Loa Loa (eye worm) hypothetical protein 0.0079 0.0859 0.1942
Echinococcus granulosus peroxisome assembly protein 26 0.0241 0.2949 0.519
Toxoplasma gondii beta-1 tubulin, putative 0.0294 0.3635 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.006 0.0121
Trichomonas vaginalis tubulin, putative 0.0294 0.3635 1
Schistosoma mansoni alpha tubulin 0.0241 0.2949 0.7152
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0088 0.0635
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0796 0.591
Brugia malayi 6-phosphofructokinase 0.0105 0.1198 0.2709
Schistosoma mansoni hypothetical protein 0.007 0.0745 0.1783
Loa Loa (eye worm) hypothetical protein 0.0145 0.1708 0.3861
Schistosoma mansoni hypothetical protein 0.0122 0.1413 0.3412
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0235 0.0612
Schistosoma mansoni coup transcription factor 0.0094 0.1052 0.253
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Echinococcus multilocularis tubulin delta chain 0.0077 0.0828 0.0828
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0094 0.1052 0.2378
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0287 0.1012
Loa Loa (eye worm) tubulin alpha 2 0.0164 0.1956 0.4422
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0217 0.0217
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0123 0.0303
Loa Loa (eye worm) tubulin beta chain 0.0294 0.3635 0.8219
Echinococcus multilocularis tubulin beta 1 chain 0.0294 0.3635 0.3635
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.1012
Giardia lamblia Beta tubulin 0.0294 0.3635 1
Giardia lamblia Alpha-tubulin 0.0241 0.2949 0.8091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0287 0.1012
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.113 0.3076
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.1732 0.4745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0094 0.1052 0.2377
Entamoeba histolytica hypothetical protein 0.007 0.0745 0.189
Echinococcus multilocularis muscleblind protein 0.0145 0.1708 0.1707
Plasmodium falciparum thioredoxin reductase 0.0046 0.0428 0.1078
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0235 0.082
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.1198 0.1198
Giardia lamblia Epsilon tubulin 0.0077 0.0828 0.2191
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0217 0.0382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0409 0.0965
Brugia malayi Tubulin alpha-2 chain 0.0241 0.2949 0.6668
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0182 0.0458
Loa Loa (eye worm) DR-78 0.0044 0.0409 0.0924
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0709 0.1914
Plasmodium vivax tubulin epsilon chain, putative 0.0177 0.2123 0.5792
Trichomonas vaginalis tubulin gamma chain, putative 0.0077 0.0828 0.2245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.0734
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0204 0.0453
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.5682 0.5681
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0828 0.2245
Schistosoma mansoni lamin 0.0026 0.0173 0.0391
Loa Loa (eye worm) tubulin beta-2A chain 0.0294 0.3635 0.8219
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0142
Mycobacterium ulcerans hypothetical protein 0.002 0.0088 0.0635
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0013 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1198 0.2708
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2719 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0287 0.0756
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.2123 0.582
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Schistosoma mansoni hypothetical protein 0.0332 0.4118 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0204 0.0453
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.108
Entamoeba histolytica tubulin family protein 0.0294 0.3635 1
Schistosoma mansoni single-minded 0.0047 0.0445 0.1053
Echinococcus granulosus CREB binding protein 0.0102 0.115 0.2024
Echinococcus granulosus Tubulin alpha 1 chain 0.0241 0.2949 0.519
Brugia malayi beta-lactamase 0.0035 0.0287 0.0648
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0198
Loa Loa (eye worm) Smad1 0.0016 0.0041 0.0092
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0235 0.0234
Onchocerca volvulus 0.0026 0.0173 0.0197
Leishmania major beta tubulin 0.0294 0.3635 1
Trypanosoma brucei tubulin delta chain 0.0077 0.0828 0.2252
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0385 0.0676
Brugia malayi Thioredoxin reductase 0.0046 0.0428 0.0968
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0385 0.0906
Brugia malayi alpha-tubulin 0.0241 0.2949 0.6668
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0287 0.2311
Schistosoma mansoni cpg binding protein 0.0028 0.0195 0.0445
Onchocerca volvulus Bile acid receptor homolog 0.0094 0.1052 0.2223
Schistosoma mansoni zinc finger protein 0.0044 0.0409 0.0965
Loa Loa (eye worm) beta-tubulin 0.0294 0.3635 0.8219
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.0409 0.0965
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0392 0.0689
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0667
Echinococcus granulosus intermediate filament protein 0.0026 0.0173 0.0304
Loa Loa (eye worm) alpha-tubulin 0.0241 0.2949 0.6667
Loa Loa (eye worm) hypothetical protein 0.0145 0.1708 0.3861
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0235 0.0531
Echinococcus multilocularis lamin dm0 0.0026 0.0173 0.0173
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0162 0.0337
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0094 0.1052 0.1051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 0.0748
Brugia malayi Cytochrome P450 family protein 0.0051 0.0491 0.1111
Echinococcus granulosus jun protein 0.0081 0.0888 0.1562
Echinococcus multilocularis Tubulin alpha 1 chain 0.0241 0.2949 0.2949
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0287 0.1012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.0409 0.0925
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0094 0.1052 0.185
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0105 0.1188 0.2687
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Loa Loa (eye worm) hypothetical protein 0.0241 0.2949 0.6667
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0385 0.0384
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0041 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Echinococcus granulosus tubulin alpha 3 chain 0.0241 0.2949 0.519
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0287 0.2311
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0392 0.1047
Echinococcus multilocularis beta tubulin 0.0294 0.3635 0.3635
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0204 0.0526
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0325 0.0791
Loa Loa (eye worm) tubulin alpha-3 chain 0.0141 0.1655 0.3741
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0325 0.0713
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0041 0.0077
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0409 0.0409
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0204 0.0526
Brugia malayi Cytochrome P450 family protein 0.0022 0.0123 0.0277
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0325 0.0791
Leishmania major beta tubulin 0.0294 0.3635 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0294 0.3635 0.8219
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0071 0.0161
Schistosoma mansoni tubulin subunit epsilon 0.0177 0.2123 0.5139
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.0409 0.0719
Trypanosoma brucei alpha tubulin 0.0241 0.2949 0.8105
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0204 0.1406
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0094 0.1052 0.253
Brugia malayi hypoxia-induced factor 1 0.0146 0.1723 0.3895
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0204 0.0453
Onchocerca volvulus 0.0064 0.0662 0.1324
Schistosoma mansoni CREB-binding protein 2 0.0102 0.115 0.2771
Leishmania major beta tubulin 0.0294 0.3635 1
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0409 0.0408
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0476 0.1279
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0071 0.016
Loa Loa (eye worm) alpha-tubulin 0.0241 0.2949 0.6667
Leishmania major beta tubulin 0.0294 0.3635 1
Echinococcus granulosus alpha tubulin 0.0241 0.2949 0.519
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1601 0.2818
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0391
Trypanosoma cruzi tubulin delta chain 0.0077 0.0828 0.2252
Mycobacterium ulcerans thymidylate synthase 0.0104 0.1182 0.9868
Plasmodium vivax tubulin beta chain, putative 0.0294 0.3635 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.1012
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.108
Echinococcus granulosus muscleblind protein 0.0145 0.1708 0.3005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Echinococcus granulosus tubulin subunit TubB 0.0241 0.2949 0.519
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.014 0.1645 0.1644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0409 0.0965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0071 0.0161
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0235 0.0412
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0041 0.0092
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0071 0.0084
Brugia malayi nuclear receptor NHR-88 0.0094 0.1052 0.2378
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0041 0.0236
Echinococcus multilocularis CREB binding protein 0.0016 0.0044 0.0043
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.1198 0.2108
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0287 0.0504
Loa Loa (eye worm) hypothetical protein 0.0026 0.0167 0.0377
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0409 0.0719
Trichomonas vaginalis tubulin alpha chain, putative 0.01 0.113 0.3076
Mycobacterium tuberculosis Probable reductase 0.0105 0.1187 0.4341
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Brugia malayi phosphofructokinase 0.0105 0.1198 0.2709
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0071 0.0492
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0428 0.1535
Echinococcus multilocularis smad 0.0016 0.0041 0.0041
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0173 0.0392
Echinococcus granulosus smad 0.0016 0.0041 0.0071
Schistosoma mansoni tubulin subunit alpha 0.0077 0.0828 0.1987
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0041 0.0092
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0177 0.2123 0.5824
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0745 0.0744
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.1732 0.4745
Echinococcus granulosus chromobox protein 1 0.0068 0.0709 0.1247
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.1198 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0392 0.1038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0428 0.1078
Brugia malayi hypothetical protein 0.0024 0.0151 0.0342
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1198 0.3272
Schistosoma mansoni smad1 5 8 and 0.0016 0.0041 0.0069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.0084
Loa Loa (eye worm) BEN-1 protein 0.0294 0.3635 0.8219
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0094 0.1052 0.253
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0362 0.0956
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0478 0.1133
Trichomonas vaginalis esterase, putative 0.0035 0.0287 0.0748
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0204 0.0371
Giardia lamblia Alpha-tubulin 0.0241 0.2949 0.8091
Brugia malayi 6-phosphofructokinase 0.0105 0.1198 0.2709
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0796 0.2102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0235 0.0234
Trypanosoma cruzi tubulin delta chain 0.0077 0.0828 0.2252
Echinococcus granulosus CREB binding protein 0.0016 0.0044 0.0076
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0041 0.0071
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0151 0.0382
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0409 0.0719
Echinococcus granulosus beta tubulin 0.0294 0.3635 0.6398
Echinococcus multilocularis tubulin gamma 1 chain 0.0177 0.2123 0.2122
Loa Loa (eye worm) thymidylate synthase 0.0104 0.1182 0.2672
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0041 0.0236
Loa Loa (eye worm) beta-lactamase 0.0035 0.0287 0.0647
Leishmania major trypanothione reductase 0.0046 0.0428 0.1146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0094 0.1052 0.2377
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.2853 0.645
Entamoeba histolytica hypothetical protein 0.007 0.0745 0.189
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1187 0.4341
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0796 0.18
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.0409 0.0924
Brugia malayi Muscleblind-like protein 0.0145 0.1708 0.3862
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0409 0.0719
Toxoplasma gondii thioredoxin reductase 0.0046 0.0428 0.1146
Brugia malayi hypothetical protein 0.005 0.0478 0.1081
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0409 0.0741
Echinococcus granulosus tumor protein p63 0.0328 0.4071 0.7165
Brugia malayi ecdysone receptor 0.0044 0.0409 0.0925
Schistosoma mansoni alpha tubulin 0.0241 0.2949 0.7152
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.036 0.0847
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0409 0.0923
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0041 0.0071
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0409 0.0741
Schistosoma mansoni tubulin subunit alpha 0.0241 0.2949 0.7152
Loa Loa (eye worm) hypothetical protein 0.003 0.0219 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0094 0.1052 0.2378
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.1198 0.2887
Echinococcus granulosus tubulin alpha 1C chain 0.0241 0.2949 0.519
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.0152
Plasmodium falciparum tubulin gamma chain 0.0177 0.2123 0.5792
Echinococcus granulosus Tubulin alpha 1 chain 0.0241 0.2949 0.519
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0164 0.1956 0.536
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0151 0.0382
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.113 0.3076
Brugia malayi hypothetical protein 0.0016 0.0039 0.0089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1187 0.4341
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0151 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0217 0.0498
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0041 0.0077
Schistosoma mansoni smad 0.0016 0.0041 0.0069
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0088 0.0278
Echinococcus granulosus Tubulin beta 2C chain 0.0294 0.3635 0.6398
Loa Loa (eye worm) hypothetical protein 0.005 0.0478 0.108
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0071 0.0215
Leishmania major hypothetical protein, conserved 0.0024 0.0151 0.0382
Loa Loa (eye worm) CBP-B 0.0072 0.0762 0.1723
Brugia malayi beta-lactamase family protein 0.0035 0.0287 0.0648
Loa Loa (eye worm) acetyltransferase 0.0142 0.1674 0.3786
Brugia malayi conserved hypotetical protein 0.0044 0.0409 0.0925
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0409 0.0409
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0598 0.1615
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Loa Loa (eye worm) tubulin alpha chain 0.0241 0.2949 0.6667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.1052 0.185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Trichomonas vaginalis tubulin gamma chain, putative 0.0294 0.3635 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0709 0.0708
Echinococcus granulosus Tubulin beta 2C chain 0.0294 0.3635 0.6398
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0071 0.0161
Schistosoma mansoni chromobox protein 0.0068 0.0709 0.1695
Loa Loa (eye worm) hypothetical protein 0.0141 0.1655 0.3741
Mycobacterium ulcerans endonuclease IV 0.0074 0.0796 0.661
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0094 0.1052 0.2378
Echinococcus multilocularis CREB binding protein 0.0071 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0796 0.2102
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0287 0.0667
Brugia malayi isocitrate dehydrogenase 0.0031 0.0235 0.0531
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0123 0.0303
Brugia malayi MH2 domain containing protein 0.0016 0.0041 0.0093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0094 0.1052 0.253
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0478 0.1133
Echinococcus multilocularis thyroid hormone receptor alpha 0.0216 0.263 0.2629
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0204 0.2154
Trichomonas vaginalis tubulin epsilon chain, putative 0.0077 0.0828 0.2245
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0094 0.1052 0.253
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.0084
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.1182 0.2849
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0325 0.0546
Plasmodium falciparum glutathione reductase 0.0046 0.0428 0.1078
Schistosoma mansoni intermediate filament proteins 0.0026 0.0173 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0123 0.0276
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.0409 0.0719
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0094 0.1052 0.185
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0162 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Plasmodium vivax glutathione reductase, putative 0.0046 0.0428 0.1078
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0017 0.0037
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0385 0.4552
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0094 0.1052 0.185
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0241 0.2949 0.8104
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0409 0.0409
Leishmania major beta tubulin 0.0294 0.3635 1
Echinococcus granulosus geminin 0.0332 0.4118 0.7248
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Leishmania major zeta tubulin, putative 0.0077 0.0828 0.2252
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0182 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0094 0.1052 0.2378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0094 0.1052 0.1051
Echinococcus multilocularis lamin 0.0026 0.0173 0.0173
Brugia malayi Tubulin alpha chain 0.0077 0.0828 0.1873
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0235 0.0612
Leishmania major beta tubulin 0.0294 0.3635 1
Trypanosoma brucei alpha tubulin 0.0241 0.2949 0.8105
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Echinococcus multilocularis tubulin subunit TubB 0.0241 0.2949 0.2949
Echinococcus multilocularis tumor protein p63 0.0328 0.4071 0.4071
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1338 0.4898
Giardia lamblia Gamma tubulin 0.0177 0.2123 0.5792
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.0409 0.0965
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.1198 0.438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.1052 0.2378
Brugia malayi tubulin alpha-2 chain 0.0241 0.2949 0.6668
Echinococcus multilocularis ecdysone induced protein 78C 0.0094 0.1052 0.1051
Onchocerca volvulus 0.003 0.0219 0.0302
Onchocerca volvulus TPPP family protein homolog 0.0355 0.4423 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0287 0.2066
Schistosoma mansoni nuclear receptor 0.0044 0.0409 0.0965
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0173 0.0391
Echinococcus multilocularis Smad4 0.0016 0.0041 0.0041
Loa Loa (eye worm) tubulin beta chain 0.0077 0.0828 0.1872
Echinococcus granulosus tubulin gamma 1 chain 0.0177 0.2123 0.3735
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Plasmodium falciparum tubulin delta chain, putative 0.0077 0.0828 0.2191
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0094 0.1052 0.2378
Echinococcus multilocularis tubulin alpha chain 0.0241 0.2949 0.2949
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0142
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0041 0.0069
Brugia malayi hypothetical protein 0.007 0.0745 0.1684
Toxoplasma gondii beta tubulin 0.0294 0.3635 1
Leishmania major cytochrome p450-like protein 0.0022 0.0123 0.0303
Echinococcus multilocularis Tubulin alpha 1 chain 0.0241 0.2949 0.2949
Leishmania major delta tubulin, putative 0.0077 0.0828 0.2252
Onchocerca volvulus 0.0035 0.0293 0.0473
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.1182 0.8823
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0204 0.0453
Brugia malayi glutathione reductase 0.0046 0.0428 0.0968
Schistosoma mansoni hypothetical protein 0.0332 0.4118 1
Trypanosoma brucei beta tubulin 0.0294 0.3635 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0745 0.131
Brugia malayi MH2 domain containing protein 0.0234 0.2853 0.645
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.5682 0.5681
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0088 0.0199
Trypanosoma brucei beta tubulin 0.0294 0.3635 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0151 0.0308
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Entamoeba histolytica tubulin alpha chain, putative 0.0241 0.2949 0.8074
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0077 0.0828 0.2245
Schistosoma mansoni cpg binding protein 0.0029 0.0216 0.0495
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0235 0.0234
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.1182 0.4322
Schistosoma mansoni tubulin subunit beta 0.0077 0.0828 0.1987
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0094 0.1052 0.2378
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0041 0.0068
Brugia malayi PAS domain containing protein 0.0047 0.0445 0.1007
Onchocerca volvulus 0.023 0.2813 0.6285
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0828 0.2252
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Brugia malayi p25-alpha family protein 0.0355 0.4423 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.006 0.0121
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0287 0.1012
Echinococcus multilocularis tubulin alpha chain 0.0241 0.2949 0.2949
Echinococcus granulosus lamin dm0 0.0026 0.0173 0.0304
Brugia malayi Flap endonuclease-1 0.0025 0.0162 0.0366
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0287 0.0748
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0235 0.0234
Schistosoma mansoni tubulin subunit gamma 0.0177 0.2123 0.5139
Plasmodium falciparum alpha tubulin 1 0.0241 0.2949 0.8091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0094 0.1052 0.185
Echinococcus multilocularis tubulin alpha chain 0.0241 0.2949 0.2949
Schistosoma mansoni cpg binding protein 0.0029 0.0216 0.0495
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0141 0.1655 0.4528
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0409 0.0965
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0204 0.0518
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.1732 0.4745
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0041 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0094 0.1052 0.2378
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0162 0.0411
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0162 0.0403
Trichomonas vaginalis tubulin beta chain, putative 0.0294 0.3635 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1723 0.3895
Trypanosoma cruzi alpha tubulin, putative 0.0241 0.2949 0.8105
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.0409 0.0409
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0235 0.0539
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0071 0.0124
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0428 0.0967
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Schistosoma mansoni Smad4 0.0016 0.0041 0.0069
Onchocerca volvulus 0.0041 0.036 0.0628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0217 0.0498
Schistosoma mansoni tubulin subunit alpha 0.0241 0.2949 0.7152
Echinococcus granulosus beta tubulin 0.0294 0.3635 0.6398
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Brugia malayi MH2 domain containing protein 0.0016 0.0041 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.1198 0.3162
Trypanosoma brucei zeta tubulin, putative 0.0077 0.0828 0.2252
Brugia malayi Steroid receptor seven-up type 2 0.0094 0.1052 0.2378
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0204 0.2154
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.5682 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0828 0.2245
Echinococcus granulosus chromobox protein 1 0.0068 0.0709 0.1247
Schistosoma mansoni jun-related protein 0.0066 0.0691 0.1652
Trichomonas vaginalis tubulin gamma chain, putative 0.0177 0.2123 0.582
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0287 0.1012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0041 0.0077
Brugia malayi Tubulin gamma chain 0.0177 0.2123 0.4799
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0478 0.0477
Echinococcus multilocularis tubulin alpha 3 chain 0.0241 0.2949 0.2949
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0709 0.1602
Leishmania major beta tubulin 0.0294 0.3635 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0216 0.0215
Leishmania major beta tubulin 0.0294 0.3635 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0294 0.3635 0.3635
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Echinococcus granulosus tubulin alpha chain 0.0241 0.2949 0.519
Echinococcus granulosus ecdysone induced protein 78C 0.0094 0.1052 0.185
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0162 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0094 0.1052 0.2377
Loa Loa (eye worm) hypothetical protein 0.0035 0.0287 0.0647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0094 0.1052 0.2377
Onchocerca volvulus 0.0035 0.0287 0.0458
Echinococcus multilocularis geminin 0.0332 0.4118 0.4118
Plasmodium falciparum tubulin epsilon chain, putative 0.0177 0.2123 0.5792
Toxoplasma gondii endonuclease IV APN 0.0074 0.0796 0.2163
Brugia malayi chromobox protein homolog 3 0.0038 0.0325 0.0735
Onchocerca volvulus 0.0094 0.1052 0.2223
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.0409 0.0924
Loa Loa (eye worm) BEN-1 protein 0.0294 0.3635 0.8219
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0409 0.0965
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0287 0.0647
Trypanosoma brucei alpha tubulin, putative 0.01 0.113 0.3083
Echinococcus granulosus tubulin delta chain 0.0077 0.0828 0.1457
Brugia malayi Cytochrome P450 family protein 0.0022 0.0123 0.0277
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0162 0.0411
Trypanosoma cruzi tubulin gamma chain 0.0177 0.2123 0.5824
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0041 0.0077
Echinococcus multilocularis 0.0014 0.0013 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0235 0.054
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0041 0.0103
Echinococcus granulosus tubulin epsilon chain 0.0177 0.2123 0.3735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.005 0.0478 0.108
Schistosoma mansoni nuclear hormone receptor 0.0094 0.1052 0.253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0362 0.0632
Leishmania major gamma-tubulin 0.0177 0.2123 0.5824
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0491
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0016
Brugia malayi nuclear receptor NHR-67 0.0044 0.0409 0.0925
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0204 0.0526
Echinococcus granulosus tubulin beta 4A class IVa 0.0294 0.3635 0.6398
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.1732 0.4704
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.1198 0.3272
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0392 0.1038
Loa Loa (eye worm) hypothetical protein 0.0164 0.1956 0.4422
Brugia malayi Pre-SET motif family protein 0.0203 0.2452 0.5544
Echinococcus granulosus Tubulin beta 2C chain 0.0294 0.3635 0.6398
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0041 0.0092
Onchocerca volvulus 0.0044 0.0409 0.0741
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0041 0.0071
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.1198 1
Trypanosoma cruzi zeta tubulin, putative 0.0077 0.0828 0.2252
Toxoplasma gondii alpha-tubulin I, putative 0.0241 0.2949 0.8105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0094 0.1052 0.2378
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0123 0.0927
Loa Loa (eye worm) tubulin gamma chain 0.0177 0.2123 0.4799
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1198 0.3265
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0385 0.3137
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0392 0.0977
Brugia malayi photoreceptor-specific nuclear receptor 0.0094 0.1052 0.2378
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0041 0.0077
Brugia malayi hypothetical protein 0.005 0.0478 0.1081
Plasmodium falciparum flap endonuclease 1 0.0025 0.0162 0.0337
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0041 0.0077
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Schistosoma mansoni chromobox protein 0.0068 0.0709 0.1695
Leishmania major hypothetical protein, conserved 0.0035 0.0287 0.0756
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.1732 0.4745
Brugia malayi hypothetical protein 0.0158 0.1881 0.4254
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1198 0.3265
Brugia malayi Tubulin beta-1 chain 0.0294 0.3635 0.8219
Echinococcus granulosus tubulin alpha chain 0.0241 0.2949 0.519
Brugia malayi Smad1 0.0016 0.0041 0.0093
Mycobacterium tuberculosis Conserved protein 0.0035 0.0287 0.1012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0217 0.0565
Trypanosoma brucei beta tubulin 0.0294 0.3635 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0041 0.0077
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0796 0.2895
Brugia malayi tubulin alpha chain - mouse 0.0241 0.2949 0.6668
Schistosoma mansoni RAR-like nuclear receptor 0.0094 0.1052 0.253
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0173 0.0391
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Echinococcus granulosus flap endonuclease 1 0.0025 0.0162 0.0284
Onchocerca volvulus 0.0028 0.0195 0.0248
Echinococcus multilocularis CREB binding protein 0.0016 0.0044 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0151 0.0382
Loa Loa (eye worm) pax transcription factor protein 2 0.0234 0.2852 0.6449
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Echinococcus multilocularis Tubulin beta 2C chain 0.0294 0.3635 0.3635
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Giardia lamblia Beta tubulin 0.0294 0.3635 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0196 0.0344
Echinococcus granulosus CREB binding protein 0.0064 0.0664 0.1167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0094 0.1052 0.2378
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0235 0.0612
Trypanosoma cruzi epsilon tubulin, putative 0.0177 0.2123 0.5824
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.1198 0.3265
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0392 0.1047
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.1198 0.2708
Echinococcus multilocularis CREB binding protein 0.0016 0.0044 0.0043
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.0409 0.0925
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.006 0.0121
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0235 0.0234
Echinococcus multilocularis tubulin alpha 3 chain 0.0241 0.2949 0.2949
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2798 0.6327
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0094 0.1052 0.253
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0428 0.0428
Trichomonas vaginalis set domain proteins, putative 0.023 0.2813 0.7727
Entamoeba histolytica tubulin gamma chain 0.0177 0.2123 0.5756
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1674 0.3786
Brugia malayi Cytochrome P450 family protein 0.0014 0.0013 0.0029
Echinococcus granulosus CREB binding protein 0.0016 0.0044 0.0076
Mycobacterium ulcerans cell division protein FtsZ 0.0077 0.0828 0.6882
Leishmania major beta tubulin 0.0294 0.3635 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Brugia malayi Heterochromatin protein 1 0.0068 0.0709 0.1603
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0217 0.0217
Echinococcus granulosus FTZ F1 alpha 0.0094 0.1052 0.185
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.0409 0.0409
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Echinococcus granulosus tubulin alpha 1C chain 0.0241 0.2949 0.519
Mycobacterium leprae conserved hypothetical protein 0.002 0.0088 0.0568
Leishmania major beta tubulin 0.0294 0.3635 1
Echinococcus multilocularis FTZ F1 alpha 0.0094 0.1052 0.1051
Toxoplasma gondii beta-tubulin, putative 0.0294 0.3635 1
Toxoplasma gondii alpha tubulin TUBA1 0.0241 0.2949 0.8105
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.0409 0.0719
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0478 0.1081
Brugia malayi nuclear hormone receptor 0.0094 0.1052 0.2378
Schistosoma mansoni nuclear receptor 0.0044 0.0409 0.0965
Schistosoma mansoni steroid hormone receptor ad4bp 0.0094 0.1052 0.253
Schistosoma mansoni thyroid hormone receptor 0.0216 0.263 0.6375
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0325 0.0853
Plasmodium vivax SET domain protein, putative 0.003 0.0217 0.0491
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Toxoplasma gondii exonuclease III APE 0.0018 0.0071 0.0161
Brugia malayi Nuclear hormone receptor-like 1 0.0094 0.1052 0.2378
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0287 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0325 0.0853
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0235 0.0612
Brugia malayi Pre-SET motif family protein 0.003 0.0217 0.0492
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0385 0.087
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Schistosoma mansoni hypothetical protein 0.005 0.0484 0.1147
Brugia malayi Tubulin beta chain 0.01 0.113 0.2554
Echinococcus granulosus tubulin alpha chain 0.0241 0.2949 0.519
Schistosoma mansoni tubulin subunit alpha 0.0241 0.2949 0.7152
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0428 0.0753
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0888 0.1562
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0409 0.0925
Leishmania major alpha tubulin 0.0241 0.2949 0.8105
Echinococcus multilocularis Tubulin beta 2C chain 0.0294 0.3635 0.3635
Echinococcus multilocularis musashi 0.0026 0.0173 0.0173
Echinococcus granulosus tubulin alpha 3 chain 0.0241 0.2949 0.519
Plasmodium falciparum tubulin beta chain 0.0294 0.3635 1
Brugia malayi nuclear hormone receptor 0.0044 0.0409 0.0925
Brugia malayi MH1 domain containing protein 0.0016 0.0041 0.0093
Echinococcus multilocularis thymidylate synthase 0.0104 0.1182 0.1182
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0077 0.0828 0.2252
Brugia malayi hypothetical protein 0.0064 0.0662 0.1497
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1338 0.4898
Brugia malayi intermediate filament protein 0.0026 0.0173 0.0392
Trypanosoma brucei beta tubulin 0.0294 0.3635 1
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.0409 0.0925
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0385 0.2805
Loa Loa (eye worm) hypothetical protein 0.0094 0.1052 0.2377
Echinococcus multilocularis Tubulin alpha 1 chain 0.0241 0.2949 0.2949
Echinococcus granulosus Tubulin beta 2C chain 0.0294 0.3635 0.6398
Loa Loa (eye worm) hypothetical protein 0.0074 0.0796 0.1799
Echinococcus multilocularis tubulin alpha chain 0.0241 0.2949 0.2949
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0094 0.1052 0.1051
Loa Loa (eye worm) hypothetical protein 0.0044 0.0409 0.0924
Brugia malayi nuclear receptor RXR 0.0044 0.0409 0.0925
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0888 0.0888
Plasmodium vivax delta tubulin, putative 0.0077 0.0828 0.2191
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0094 0.1052 0.2378
Plasmodium falciparum alpha tubulin 2 0.0241 0.2949 0.8091
Mycobacterium tuberculosis Cell division protein FtsZ 0.0077 0.0828 0.3014
Mycobacterium ulcerans lipase LipD 0.0035 0.0287 0.2311
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.2949 0.8104
Schistosoma mansoni tubulin subunit beta 0.0294 0.3635 0.8824
Loa Loa (eye worm) tubulin alpha-2 chain 0.0241 0.2949 0.6667
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0094 0.1052 0.2223
Echinococcus granulosus tubulin alpha chain 0.0241 0.2949 0.519
Loa Loa (eye worm) hypothetical protein 0.0104 0.1182 0.2671
Brugia malayi Tubulin beta chain 0.0077 0.0828 0.1873
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0164 0.1956 0.4422
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0162 0.0411

Activities

Activity type Activity value Assay description Source Reference
MIC50 (functional) = 1 ug ml-1 Compound was tested in vitro for its activity against methicillin-Resistant Staphylococcus Aureus(MRSA 12) ChEMBL. 10571158
MIC50 (functional) = 2 ug ml-1 Compound was tested in vitro for its activity against Methicillin-Resistant Coagulase Negative Staphylococci(MRCNS 9) ChEMBL. 10571158
MIC90 (functional) = 2 ug ml-1 Compound was tested in vitro for its activity against methicillin-Resistant Staphylococcus Aureus(MRSA 12) ChEMBL. 10571158
MIC90 (functional) = 4 ug ml-1 Compound was tested in vitro for its activity against Methicillin-Resistant Coagulase Negative Staphylococci(MRCNS 9) ChEMBL. 10571158

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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