Detailed information for compound 1704468

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 405.902 | Formula: C18H20ClN5O2S
  • H donors: 1 H acceptors: 3 LogP: 3.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(nc(c1)C)NC(=S)N1CCN(CC1)c1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C18H20ClN5O2S/c1-12-9-13(2)20-17(10-12)21-18(27)23-7-5-22(6-8-23)16-4-3-14(24(25)26)11-15(16)19/h3-4,9-11H,5-8H2,1-2H3,(H,20,21,27)
  • InChiKey: QZPLLFLASMBPIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 4 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129142 All targets in OG5_129142
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129142 All targets in OG5_129142
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. Get druggable targets OG5_129142 All targets in OG5_129142
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129142 All targets in OG5_129142
Candida albicans similar to C.tropicalis HDE1 (P22414) peroxisomal trifunctional hydratase-dehydrogenase-epimerase important in fatty acid beta-o Get druggable targets OG5_129142 All targets in OG5_129142
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans dehydratase Get druggable targets OG5_129142 All targets in OG5_129142
Neospora caninum peroxisomal multifunctional enzyme type 2, putative Get druggable targets OG5_129142 All targets in OG5_129142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Get druggable targets OG5_129142 All targets in OG5_129142
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable 3-hydroxyacyl-thioester dehydratase HtdY Get druggable targets OG5_129142 All targets in OG5_129142
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 Get druggable targets OG5_129142 All targets in OG5_129142
Neospora caninum peroxisomal multifunctional enzyme, putative Get druggable targets OG5_129142 All targets in OG5_129142
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase Get druggable targets OG5_129142 All targets in OG5_129142
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_129142 All targets in OG5_129142
Brugia malayi maoC like domain containing protein Get druggable targets OG5_129142 All targets in OG5_129142
Toxoplasma gondii MaoC family domain-containing protein Get druggable targets OG5_129142 All targets in OG5_129142
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129142 All targets in OG5_129142
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0043 0.017 0.0523
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0024 0.0028
Mycobacterium tuberculosis Probable 3-hydroxyacyl-thioester dehydratase HtdY 0.0048 0.0227 0.0457
Brugia malayi Inositol-1 0.0036 0.0094 0.0134
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi putative neuropeptide receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.017 0.0277
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0081 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.017 0.0258
Schistosoma mansoni amine GPCR 0.0043 0.017 0.0258
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Onchocerca volvulus Huntingtin homolog 0.0119 0.1038 0.341
Echinococcus multilocularis serotonin transporter 0.0169 0.1609 0.1598
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0013 0.0001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.017 0.0258
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0488 0.0787
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.017 0.0258
Schistosoma mansoni neuropeptide receptor 0.0043 0.017 0.0258
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0199
Entamoeba histolytica hypothetical protein 0.0035 0.0084 0.8783
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0029 0.0013 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0753 0.0742
Loa Loa (eye worm) hypothetical protein 0.0119 0.1038 0.1696
Loa Loa (eye worm) hypothetical protein 0.0049 0.0245 0.04
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0488 0.0654
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0827 0.1333
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1212 1
Echinococcus multilocularis lamin 0.0059 0.0361 0.035
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0288 0.0309
Schistosoma mansoni biogenic amine receptor 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.002
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0024 0.0035
Brugia malayi bZIP transcription factor family protein 0.026 0.2635 0.4294
Toxoplasma gondii ABC1 family protein 0.0071 0.0488 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.017 0.0176
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0013 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.017 0.0258
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.017 0.0176
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.017 0.0158
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0136 0.0222
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Echinococcus multilocularis sodium and chloride dependent glycine 0.0029 0.0013 0.0001
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.017 0.0158
Schistosoma mansoni sodium-dependent amino acid transporter 0.0029 0.0013 0.0001
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0827 0.1333
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0534 0.0854
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.017 0.0258
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0136 0.021
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0488 0.0798
Giardia lamblia PHD finger protein 15 0.0029 0.0012 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Brugia malayi beta-lactamase family protein 0.0071 0.0488 0.0779
Echinococcus granulosus jun protein 0.026 0.2635 0.2935
Onchocerca volvulus 0.0071 0.0488 0.1582
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.017 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Echinococcus multilocularis fmrfamide receptor 0.0043 0.017 0.0158
Echinococcus multilocularis serotonin receptor 0.0043 0.017 0.0158
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.017 0.0277
Loa Loa (eye worm) hypothetical protein 0.0413 0.437 0.7141
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0029 0.0013 0.0001
Schistosoma mansoni opsin-like receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Plasmodium falciparum amino acid transporter, putative 0.0029 0.0013 0.0203
Schistosoma mansoni amine GPCR 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1059 0.219
Schistosoma mansoni neuropeptide receptor 0.0043 0.017 0.0258
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0024 0.0035
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0512 0.0693
Echinococcus granulosus peregrin 0.0029 0.0012 0.0000024532
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Echinococcus granulosus neuropeptide s receptor 0.0043 0.017 0.0176
Onchocerca volvulus 0.0071 0.0488 0.1582
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0488 0.1002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.017 0.0258
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.017 0.0258
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus sex peptide receptor 0.0043 0.017 0.0176
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0001
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.017 0.0158
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus serotonin transporter 0.0169 0.1609 0.1787
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1059 0.219
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0024 0.0039
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0024 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Echinococcus multilocularis allatostatin A receptor 0.0043 0.017 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.017 0.0176
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0048 0.0079
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0413 0.437 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0024 0.0028
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.017 0.0176
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0051 0.0092
Schistosoma mansoni amine GPCR 0.0043 0.017 0.0258
Echinococcus granulosus allatostatin A receptor 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0118
Echinococcus multilocularis somatostatin receptor 0.0043 0.017 0.0158
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0161
Brugia malayi GnHR receptor homolog 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0169 0.1609 0.2629
Brugia malayi Dopamine receptor 0.0043 0.017 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0001
Echinococcus multilocularis orexin receptor type 2 0.0043 0.017 0.0158
Brugia malayi hypothetical protein 0.0294 0.302 0.4925
Schistosoma mansoni biogenic amine receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0169 0.1609 0.2629
Entamoeba histolytica hypothetical protein 0.0035 0.0084 0.8783
Brugia malayi Protein kinase domain containing protein 0.0251 0.254 0.4139
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0024 0.0035
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.057 0.0913
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0024 0.0028
Onchocerca volvulus 0.0294 0.302 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0013 0.0001
Mycobacterium tuberculosis Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. 0.0048 0.0227 0.0457
Brugia malayi beta-lactamase 0.0071 0.0488 0.0779
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0024 0.0028
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0488 0.0533
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0488 0.0779
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0364 0.7423
Loa Loa (eye worm) hypothetical protein 0.01 0.0827 0.1351
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1059 0.219
Echinococcus granulosus orexin receptor type 2 0.0043 0.017 0.0176
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0827 0.0911
Onchocerca volvulus 0.01 0.0822 0.2691
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0024 0.0035
Trypanosoma brucei C-8 sterol isomerase, putative 0.0413 0.437 1
Mycobacterium leprae Probable lipase LipE 0.0071 0.0488 0.3993
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Onchocerca volvulus 0.0043 0.017 0.0523
Entamoeba histolytica hypothetical protein 0.0035 0.0084 0.8783
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Toxoplasma gondii hypothetical protein 0.0029 0.0013 0.0118
Onchocerca volvulus 0.0029 0.0013 0.0002
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0288 0.5839
Mycobacterium tuberculosis Conserved protein 0.0071 0.0488 0.1002
Loa Loa (eye worm) beta-lactamase 0.0071 0.0488 0.0798
Onchocerca volvulus 0.0043 0.017 0.0523
Echinococcus multilocularis serotonin receptor 0.0043 0.017 0.0158
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0094 0.0082
Echinococcus granulosus neuropeptide receptor 0.0043 0.017 0.0176
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.017 0.0258
Brugia malayi neuropeptide F receptor 0.0043 0.017 0.0258
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0136 0.0256
Mycobacterium ulcerans hypothetical protein 0.0048 0.0227 0.0359
Trypanosoma brucei trypanothione reductase 0.0053 0.0288 0.0644
Brugia malayi jmjC domain containing protein 0.0035 0.0081 0.0112
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.017 0.0176
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0013 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0094 0.0142
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.017 0.0176
Leishmania major hypothetical protein, conserved 0.0071 0.0488 0.1102
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.017 0.0277
Loa Loa (eye worm) hypothetical protein 0.0058 0.0349 0.057
Schistosoma mansoni adenoreceptor 0.0043 0.017 0.0258
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.017 0.0523
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Echinococcus multilocularis musashi 0.0059 0.0361 0.035
Loa Loa (eye worm) hypothetical protein 0.049 0.5252 0.8581
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0024 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.017 0.0158
Echinococcus granulosus geminin 0.0334 0.348 0.3882
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0012 0.0106
Loa Loa (eye worm) CYP4Cod1 0.004 0.0136 0.0222
Schistosoma mansoni jun-related protein 0.0211 0.2083 0.339
Mycobacterium tuberculosis Conserved protein 0.0071 0.0488 0.1002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Onchocerca volvulus 0.0043 0.017 0.0523
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0488 0.1002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0488 0.0779
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Brugia malayi G-protein coupled receptor 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0024 0.0035
Brugia malayi Serotonin receptor 0.0043 0.017 0.0258
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0364 0.0576
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Schistosoma mansoni hypothetical protein 0.0334 0.348 0.5678
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0413 0.437 0.7135
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Loa Loa (eye worm) hypothetical protein 0.0068 0.0453 0.0741
Onchocerca volvulus 0.01 0.0827 0.2707
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0169 0.1609 0.2614
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0012 0.0000021944
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0081 0.0132
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0024 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.049 0.5252 0.5246
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Echinococcus multilocularis jun protein 0.026 0.2635 0.2626
Loa Loa (eye worm) hypothetical protein 0.0059 0.0361 0.0591
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Schistosoma mansoni lamin 0.0059 0.0361 0.0572
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.05 0.0488
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.017 0.0258
Echinococcus granulosus serotonin receptor 0.0043 0.017 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0043 0.017 0.0158
Brugia malayi maoC like domain containing protein 0.0048 0.0227 0.0351
Echinococcus granulosus sodium and chloride dependent glycine 0.0029 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.017 0.0277
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0094 0.1806
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Brugia malayi Dopamine receptor protein 2 0.0043 0.017 0.0258
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0359 0.0587
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0136 0.0222
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0012 0.0000024532
Mycobacterium tuberculosis Conserved protein 0.0071 0.0488 0.1002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1212 0.2509
Brugia malayi neuropeptide F receptor 0.0043 0.017 0.0258
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0364 0.0394
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.017 0.0258
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.017 0.0158
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.017 0.0158
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.017 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0488 0.1068
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0013 0.0118
Loa Loa (eye worm) fli-1 protein 0.0217 0.2156 0.3522
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.017 0.0258
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0024 0.0013
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0051 0.0367
Echinococcus multilocularis g protein coupled receptor 0.0043 0.017 0.0158
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0512 0.0693
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Onchocerca volvulus Huntingtin homolog 0.0119 0.1038 0.341
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.017 0.0176
Brugia malayi Cytochrome P450 family protein 0.004 0.0136 0.0202
Schistosoma mansoni hypothetical protein 0.0035 0.0084 0.0117
Echinococcus multilocularis neuropeptide receptor 0.0043 0.017 0.0158
Echinococcus granulosus g protein coupled receptor 0.0043 0.017 0.0176
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.017 0.0258
Echinococcus multilocularis neuropeptide receptor 0.0043 0.017 0.0158
Loa Loa (eye worm) norepinephrine transporter 0.0169 0.1609 0.2629
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus intermediate filament protein 0.0059 0.0361 0.0391
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1212 0.2509
Echinococcus multilocularis conserved hypothetical protein 0.0773 0.8463 0.8461
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.017 0.0258
Mycobacterium ulcerans hypothetical protein 0.0071 0.0488 0.0787
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0024 0.0028
Brugia malayi Cytochrome P450 family protein 0.004 0.0136 0.0202
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0361 0.0591
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0526 0.5662 0.9252
Brugia malayi cytochrome P450 0.003 0.0024 0.0019
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0024 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.017 0.0158
Schistosoma mansoni hypothetical protein 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0253 0.2554 0.4173
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0211 0.208 0.3399
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0364 0.0584
Brugia malayi hypothetical protein 0.0119 0.1038 0.1679
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.017 0.0176
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0024 0.0028
Trypanosoma brucei cytochrome P450, putative 0.004 0.0136 0.0294
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.017 0.0258
Echinococcus granulosus survival motor neuron protein 1 0.049 0.5252 0.5864
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0024 0.0028
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0048 0.0059
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.017 0.0176
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0029 0.0013 0.0001
Echinococcus multilocularis protein tyrosine kinase 0.0248 0.2507 0.2498
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0024 0.0035
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0024 0.0035
Brugia malayi Ets-domain containing protein 0.0072 0.05 0.0798
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0753 0.0829
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0488 0.1102
Brugia malayi Thioredoxin reductase 0.0053 0.0288 0.0451
Echinococcus granulosus hypothetical protein 0.0816 0.8946 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.017 0.0158
Echinococcus granulosus g protein coupled receptor 0.0043 0.017 0.0176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0488 0.1002
Mycobacterium ulcerans beta-lactamase 0.0071 0.0488 0.0787
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0488 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0024 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0288 0.0276
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0024 0.0028
Schistosoma mansoni amine GPCR 0.0043 0.017 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Onchocerca volvulus 0.0071 0.0488 0.1582
Leishmania major C-8 sterol isomerase-like protein 0.0413 0.437 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Mycobacterium ulcerans lipase LipD 0.0071 0.0488 0.0787
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.017 0.0277
Brugia malayi Cytochrome P450 family protein 0.007 0.048 0.0765
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0024 0.0035
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0084 0.0071
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0199
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0488 0.3993
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.017 0.0158
Echinococcus multilocularis sex peptide receptor 0.0043 0.017 0.0158
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0029 0.0013 0.0001
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0024 0.0028
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0488 0.0476
Brugia malayi follicle stimulating hormone receptor 0.0526 0.5662 0.9251
Schistosoma mansoni neuropeptide receptor 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable reductase 0.0121 0.1059 0.219
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.017 0.0158
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0488 0.0654
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0024 0.0141
Brugia malayi glutaminase DH11.1 0.0567 0.612 1
Leishmania major cytochrome p450-like protein 0.003 0.0024 0.0039
Plasmodium vivax amine transporter, putative 0.0029 0.0013 0.0118
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Schistosoma mansoni opsin-like receptor 0.0043 0.017 0.0258
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.017 0.0176
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.05 0.0817
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.017 0.0523
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.017 0.0258
Onchocerca volvulus 0.0043 0.017 0.0523
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0822 0.1325
Schistosoma mansoni ets-related 0.0217 0.2156 0.3509
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0029 0.0013 1
Brugia malayi sulfakinin receptor protein 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0081 0.0077
Brugia malayi Ets-domain containing protein 0.0072 0.05 0.0798
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Onchocerca volvulus 0.0043 0.017 0.0523
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1059 0.219
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0827 0.0815
Loa Loa (eye worm) solute carrier family 6 member 4 0.0169 0.1609 0.2629
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0081 0.0112
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Onchocerca volvulus 0.0043 0.017 0.0523
Plasmodium falciparum transporter, putative 0.0029 0.0013 0.0203
Schistosoma mansoni biogenic amine receptor 0.0043 0.017 0.0258
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0024 0.0028
Plasmodium falciparum glutathione reductase 0.0053 0.0288 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0488 0.0787
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.017 0.0176
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.1059 0.8729
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.017 0.0158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.0169 0.1609 0.2629
Schistosoma mansoni hypothetical protein 0.01 0.0822 0.1325
Brugia malayi hypothetical protein 0.0204 0.2002 0.3257
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Schistosoma mansoni hypothetical protein 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0001
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0024 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0488 0.1002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0488 0.0654
Echinococcus granulosus jumonji domain containing protein 0.004 0.014 0.0143
Schistosoma mansoni hypothetical protein 0.0334 0.348 0.5678
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.017 0.0158
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.017 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Echinococcus multilocularis geminin 0.0334 0.348 0.3472
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.017 0.0258
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0488 0.1002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.017 0.0277
Schistosoma mansoni sodium/chloride dependent transporter 0.0169 0.1609 0.2614
Schistosoma mansoni hypothetical protein 0.0043 0.017 0.0258
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.017 0.0277
Echinococcus multilocularis jumonji domain containing protein 0.004 0.014 0.0128
Treponema pallidum sodium- and chloride- dependent transporter 0.0169 0.1609 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.4807 1
Schistosoma mansoni glutaminase 0.0567 0.612 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.017 0.0258
Echinococcus granulosus g protein coupled receptor 0.0043 0.017 0.0176
Plasmodium falciparum thioredoxin reductase 0.0053 0.0288 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0024 0.0353
Brugia malayi Melatonin receptor type 1A 0.0043 0.017 0.0258
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1059 0.219
Loa Loa (eye worm) hypothetical protein 0.0071 0.0488 0.0798
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0024 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.026 0.2635 0.2935
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.017 0.0158
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0488 0.0779
Mycobacterium ulcerans glutaminase 0.0567 0.612 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0012 0.0106
Schistosoma mansoni neuropeptide receptor 0.0043 0.017 0.0258
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0012 0.0106
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.017 0.0176
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.017 0.0258
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0024 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0084 0.008
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi G-protein coupled receptor 0.0043 0.017 0.0258
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0094 0.0161
Loa Loa (eye worm) serotonin transporter b 0.0169 0.1609 0.2629
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0024 0.0028
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.017 0.0158
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.017 0.0258
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0361 0.0591
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Entamoeba histolytica hypothetical protein 0.0035 0.0084 0.8783
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0651 0.1046
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Leishmania major cytochrome p450-like protein 0.004 0.0136 0.0294
Brugia malayi hypothetical protein 0.0035 0.0084 0.0117
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.017 0.0176
Schistosoma mansoni histamine h1 receptor 0.0043 0.017 0.0258
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.0651 0.1046
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus fmrfamide receptor 0.0043 0.017 0.0176
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0118
Loa Loa (eye worm) hypothetical protein 0.0048 0.0227 0.037
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0043 0.0171 0.341
Onchocerca volvulus 0.0059 0.0361 0.1161
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0094 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.017 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0488 0.1002
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0024 0.0035
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.026 0.2635 0.2626
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.017 0.0158
Leishmania major trypanothione reductase 0.0053 0.0288 0.0644
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Loa Loa (eye worm) glutaminase 0.0567 0.612 1
Toxoplasma gondii hypothetical protein 0.0029 0.0013 0.0118
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.017 0.0158
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.017 0.0158
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.017 0.0176
Schistosoma mansoni gabp alpha 0.0072 0.05 0.0798
Onchocerca volvulus 0.0059 0.0361 0.1161
Schistosoma mansoni survival motor neuron protein 0.01 0.0822 0.1325
Toxoplasma gondii thioredoxin reductase 0.0053 0.0288 0.5839
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.017 0.0258
Trichomonas vaginalis glutaminase, putative 0.0567 0.612 1
Schistosoma mansoni lamin 0.0059 0.0361 0.0572
Schistosoma mansoni lipoxygenase 0.0116 0.1003 0.1622
Echinococcus granulosus g-protein coupled receptor 0.0043 0.017 0.0176
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0084 0.0117
Brugia malayi AKH receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0061 0.0382 0.0624
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi ORL1-like opioid receptor 0.0043 0.017 0.0258
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0024 0.0028
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1003 0.1109
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.017 0.0176
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.048 0.0784
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0029 0.0013 0.0001
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0288 0.0607
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis g protein coupled receptor 0.0043 0.017 0.0158
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0094 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0024 0.0028
Schistosoma mansoni amine GPCR 0.0043 0.017 0.0258
Echinococcus multilocularis peregrin 0.0029 0.0012 0.0000021944
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.017 0.0176
Schistosoma mansoni intermediate filament proteins 0.0059 0.0361 0.0572
Brugia malayi glutathione reductase 0.0053 0.0288 0.0451
Echinococcus multilocularis lamin dm0 0.0059 0.0361 0.035
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.017 0.0277
Loa Loa (eye worm) glutaminase 2 0.0567 0.612 1
Onchocerca volvulus 0.0043 0.017 0.0523
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0288 0.0585
Loa Loa (eye worm) glutathione reductase 0.0053 0.0288 0.0471
Echinococcus granulosus lamin dm0 0.0059 0.0361 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.017 0.0158
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.057 0.0624
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Loa Loa (eye worm) TK/FAK protein kinase 0.0251 0.254 0.4151
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0288 0.0471
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.05 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0024 0.0035
Mycobacterium leprae putative cytochrome p450 0.003 0.0024 0.0141
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0021
Onchocerca volvulus 0.0204 0.2002 0.6614
Brugia malayi hypothetical protein 0.0029 0.0013 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0024 0.0035
Schistosoma mansoni opsin-like receptor 0.0043 0.017 0.0258
Onchocerca volvulus 0.0043 0.017 0.0523
Trichomonas vaginalis esterase, putative 0.0071 0.0488 0.0654
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.017 0.0158
Schistosoma mansoni hypothetical protein 0.003 0.0024 0.0019
Schistosoma mansoni lipoxygenase 0.0081 0.0607 0.0973
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.057 0.0932
Echinococcus granulosus protein tyrosine kinase 0.0248 0.2507 0.2792
Leishmania major cytochrome p450-like protein 0.003 0.0024 0.0039
Brugia malayi hypothetical protein 0.049 0.5252 0.8578
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0364 0.0818
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0024 0.0028
Plasmodium falciparum phd finger protein, putative 0.0029 0.0012 0.0181
Brugia malayi intermediate filament protein 0.0059 0.0361 0.0572
Onchocerca volvulus 0.0029 0.0013 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0169 0.1609 0.2614
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0364 0.0352
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.017 0.0176
Onchocerca volvulus 0.0043 0.017 0.0523
Toxoplasma gondii MaoC family domain-containing protein 0.0029 0.0014 0.0147
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0364 0.0584
Schistosoma mansoni inositol monophosphatase 0.0036 0.0094 0.0134
Schistosoma mansoni myosin xvIII 0.0043 0.017 0.0258
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.017 0.0158
Echinococcus granulosus neuropeptide receptor 0.0043 0.017 0.0176
Brugia malayi larval opioid receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) inositol-1 0.0036 0.0094 0.0154
Echinococcus multilocularis fmrfamide receptor 0.0043 0.017 0.0158
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0029 0.0013 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Onchocerca volvulus 0.0043 0.017 0.0523
Loa Loa (eye worm) hypothetical protein 0.0294 0.302 0.4935
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.017 0.0176
Schistosoma mansoni hypothetical protein 0.0043 0.017 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0024 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1212 0.2509
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0136 0.0256
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0094 0.0092
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0029 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Plasmodium vivax glutathione reductase, putative 0.0053 0.0288 0.5839
Brugia malayi Serotonin receptor 0.0558 0.6021 0.9838
Loa Loa (eye worm) cytochrome P450 0.003 0.0024 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0488 0.1002
Schistosoma mansoni sodium/chloride dependent transporter 0.0029 0.0013 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.017 0.0158
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus granulosus somatostatin receptor 0.0043 0.017 0.0176
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0364 0.0744
Brugia malayi Fli-1 protein 0.0217 0.2156 0.3509
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0364 0.0584
Schistosoma mansoni tyrosine kinase 0.0248 0.2507 0.4084
Brugia malayi jmjC domain containing protein 0.0094 0.0753 0.1213
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0024 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0024 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0361 0.0572
Mycobacterium ulcerans dehydratase 0.0048 0.0227 0.0359
Onchocerca volvulus 0.0169 0.1609 0.5307
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Echinococcus multilocularis 0.003 0.0024 0.0012
Onchocerca volvulus 0.0029 0.0013 0.0002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.017 0.0158
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.017 0.0158
Brugia malayi G protein-coupled receptor 0.0043 0.017 0.0258
Brugia malayi Dopamine receptor protein 1 0.0043 0.017 0.0258
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.017 0.0277
Schistosoma mansoni cytochrome P450 0.003 0.0024 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0119 0.1038 0.1696
Brugia malayi RE15519p 0.0043 0.017 0.0258
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0024 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi Cytochrome P450 family protein 0.003 0.0024 0.0019
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0364 0.0576
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.017 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0488 0.0654
Brugia malayi hypothetical protein 0.0043 0.017 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0277
Brugia malayi beta-lactamase family protein 0.0071 0.0488 0.0779
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0488 0.1068
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0012 0.002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1003 0.0992
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.017 0.0158
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.057 0.0558
Schistosoma mansoni hypothetical protein 0.0211 0.2083 0.339
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.017 0.0258
Echinococcus granulosus lamin 0.0059 0.0361 0.0391
Schistosoma mansoni inositol monophosphatase 0.0036 0.0094 0.0134
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0029 0.0013 0.0001
Onchocerca volvulus 0.0043 0.017 0.0523

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.1821 uM PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Counterscreen Against HSD17b4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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