Detailed information for compound 1730834

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.875 | Formula: C25H19ClFNO3
  • H donors: 1 H acceptors: 2 LogP: 5.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)c(=O)cc(o2)c1ccc(cc1Cl)NC(=O)Cc1cccc(c1)F
  • InChi: 1S/C25H19ClFNO3/c1-2-15-6-9-23-20(11-15)22(29)14-24(31-23)19-8-7-18(13-21(19)26)28-25(30)12-16-4-3-5-17(27)10-16/h3-11,13-14H,2,12H2,1H3,(H,28,30)
  • InChiKey: HISXUFRFADKKKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.003 0.0222 0.0514
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Onchocerca volvulus 0.0038 0.0299 0.0651
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0038 0.0299 0.0693
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.1062
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0896 0.2077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Schistosoma mansoni thyroid hormone receptor 0.001 0.002 0.002
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0038 0.0299 0.0693
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 1
Plasmodium falciparum potassium channel 0.0038 0.0299 0.1383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0044
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0044 0.036 0.5976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0044
Onchocerca volvulus Putative transporter 0.003 0.0222 0.0471
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0286 0.1726
Brugia malayi major facilitator superfamily protein 0.003 0.0222 0.0514
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0155 0.1196
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.036 0.1528
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0155 0.0369
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Trypanosoma brucei glucose transporter 1E 0.0066 0.0587 0.9898
Onchocerca volvulus 0.003 0.0222 0.0471
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.002 0.002
Giardia lamblia Hypothetical protein 0.0038 0.0299 0.4921
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0038 0.0299 0.0693
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0222 0.0222
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 0.2555
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0916
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0155 0.1196
Schistosoma mansoni hypothetical protein 0.004 0.0323 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0277 0.4533
Schistosoma mansoni hypothetical protein 0.002 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.002 0.0045
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0587 0.2529
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0277 0.0277
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0592 0.0592
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.036 0.5976
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Schistosoma mansoni bromodomain containing protein 0.0064 0.0563 0.0563
Brugia malayi Pre-SET motif family protein 0.0206 0.1991 0.4614
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0277 0.3649
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Mycobacterium tuberculosis Conserved protein 0.0036 0.0277 0.0943
Loa Loa (eye worm) sugar transporter 0.003 0.0222 0.0222
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0306 0.2989 0.2989
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0155
Onchocerca volvulus 0.0048 0.0398 0.0881
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0414 0.0414
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0076 0.1062
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0277 0.4533
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0916
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.0592 0.1373
Schistosoma mansoni lozenge 0.0055 0.0471 0.0471
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0222 0.1007
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.036 0.036
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0222 0.3585
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0233 0.0233
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0398 0.0922
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2276 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0286 0.0286
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0548 0.0548
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0222 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.002 0.0045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0592 0.0592
Loa Loa (eye worm) TWK-7 protein 0.0038 0.0299 0.0299
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Trypanosoma brucei ISWI complex protein 0.0015 0.0071 0.0976
Loa Loa (eye worm) hypothetical protein 0.0042 0.0339 0.0339
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0151 0.0605
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0222 0.0222
Brugia malayi MBD3 protein 0.0148 0.1405 0.3257
Schistosoma mansoni glucose transporter 0.003 0.0222 0.0222
Brugia malayi major facilitator superfamily protein 0.003 0.0222 0.0514
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) beta-lactamase 0.0036 0.0277 0.0277
Onchocerca volvulus 0.0023 0.0155 0.0314
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.002 0.002
Schistosoma mansoni protein phosphatase type 1 0.001 0.0015 0.0015
Echinococcus multilocularis Protein lozenge 0.0055 0.0471 0.0471
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Brugia malayi hypothetical protein 0.003 0.0222 0.0514
Schistosoma mansoni alkaline phosphatase 0.0161 0.1533 0.1533
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.001 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0548 0.0548
Trypanosoma cruzi ISWI complex protein 0.0015 0.0071 0.0976
Trichomonas vaginalis glucose transporter, putative 0.003 0.0222 0.0916
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0036 0.0084
Onchocerca volvulus 0.003 0.0222 0.0471
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.002 0.002
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Giardia lamblia Hexose transporter 0.003 0.0222 0.3585
Brugia malayi Protein kinase domain containing protein 0.0031 0.0233 0.054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0587 0.9898
Echinococcus multilocularis zinc finger protein 0.0021 0.013 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0299 0.4921
Onchocerca volvulus 0.003 0.0222 0.0471
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.002 0.002
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0067 0.0592 0.281
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0155 0.0222
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0592 0.0592
Echinococcus granulosus alkaline phosphatase 0.0161 0.1533 0.1533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.002 0.0045
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.1679 0.3892
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.036 0.036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0277 0.3649
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.002 0.0045
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0155 0.2421
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0038 0.0299 0.0693
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0548 0.0548
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Toxoplasma gondii ion channel protein 0.0038 0.0299 0.1383
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.4692
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus granulosus microtubule associated protein 2 0.0682 0.6767 0.6767
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0084 0.0758 0.0758
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0046 0.0384 0.0384
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.036 0.036
Schistosoma mansoni zinc finger protein 0.0015 0.0071 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.001 0.002 0.002
Echinococcus granulosus zinc finger protein 0.0021 0.013 0.013
Trypanosoma cruzi ion transport protein, putative 0.0038 0.0299 0.4921
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) MBD3 protein 0.0148 0.1405 0.1405
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0277 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0222 0.0222
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0222
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0277 0.4533
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0592 0.0592
Schistosoma mansoni patched 1 0.0042 0.0339 0.0339
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0161 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0038 0.03 0.03
Echinococcus multilocularis Ankyrin 0.0031 0.0234 0.0234
Onchocerca volvulus 0.0438 0.4315 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.002 0.002
Onchocerca volvulus 0.003 0.0222 0.0471
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0587 0.9898
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0155 0.2421
Brugia malayi Pre-SET motif family protein 0.003 0.0222 0.0514
Loa Loa (eye worm) hypothetical protein 0.1004 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0339 0.0339
Loa Loa (eye worm) sugar transporter 0.0214 0.2071 0.2071
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0128 0.0296
Brugia malayi nuclear hormone receptor 0.001 0.002 0.0045
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0038 0.0299 0.0693
Schistosoma mansoni alkaline phosphatase 0.0161 0.1533 0.1533
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0038 0.0299 0.0299
Schistosoma mansoni glucose transport protein 0.0214 0.2071 0.2071
Echinococcus granulosus methyl CpG binding domain protein 2 0.0192 0.1849 0.1849
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0038 0.0299 0.0693
Leishmania major hypothetical protein, conserved 0.0038 0.0299 0.4921
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi hypothetical protein 0.0038 0.0299 0.0693
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0038 0.0299 0.0299
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.4692
Echinococcus granulosus expressed conserved protein 0.0091 0.0837 0.0837
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0023 0.0152 0.0356
Trichomonas vaginalis esterase, putative 0.0036 0.0277 0.1158
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0233 0.0233
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0067 0.0592 0.281
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0222
Mycobacterium ulcerans sugar transporter 0.003 0.0222 0.2548
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0514
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0514
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0038 0.0299 0.4921
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0155
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.002 0.002
Toxoplasma gondii facilitative glucose transporter GT1 0.0214 0.2071 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0286 0.0286
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0277 0.0277
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0038 0.0299 0.4921
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.1062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0414 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.002 0.0045
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0587 0.9898
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0155 0.1196
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Brugia malayi CHE-14 protein 0.0042 0.0339 0.0785
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0151 0.0351
Echinococcus multilocularis protein patched 0.0042 0.0339 0.0339
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0592 0.281
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0222 0.0222
Brugia malayi hypothetical protein 0.003 0.0222 0.0514
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0155 0.1196
Echinococcus granulosus nuclear factor of activated T cells 5 0.0306 0.2989 0.2989
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0076 0.0298
Echinococcus granulosus twik family of potassium channels 0.0038 0.0299 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.002 0.002
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0095 0.0095
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0038 0.0299 0.0693
Leishmania major glucose transporter, lmgt3 0.0066 0.0587 0.9898
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0222 0.2548
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Leishmania major hypothetical protein, conserved 0.003 0.0222 0.3585
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0233 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0277 0.1158
Onchocerca volvulus 0.0038 0.0299 0.0651
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0286 0.1199
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.002 0.002
Giardia lamblia Sugar-proton symporter 0.003 0.0222 0.3585
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0038 0.0299 0.0299
Loa Loa (eye worm) inositol-1 0.0037 0.0286 0.0286
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0155 0.1196
Loa Loa (eye worm) hypothetical protein 0.0438 0.4315 0.4315
Loa Loa (eye worm) histone methyltransferase 0.001 0.0018 0.0018
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0233 0.0233
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0277 0.0943
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0222 0.0916
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0587 0.2529
Mycobacterium ulcerans hypothetical protein 0.0023 0.0155 0.1196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0076 0.0076
Brugia malayi Inositol-1 0.0037 0.0286 0.0662
Brugia malayi Bromodomain containing protein 0.0153 0.1451 0.3363
Schistosoma mansoni hypothetical protein 0.004 0.0323 0.0323
Brugia malayi beta-lactamase family protein 0.0036 0.0277 0.0641
Plasmodium vivax sugar transporter, putative 0.003 0.0222 0.1007
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0076 0.0176
Loa Loa (eye worm) hypothetical protein 0.0175 0.1679 0.1679
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0038 0.0299 0.0693
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0587 0.2529
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0587 0.2529
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.2071 0.9093
Leishmania major potassium channel subunit-like protein 0.0038 0.0299 0.4921
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0222 0.2548
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0916
Toxoplasma gondii sugar transporter ST1 0.003 0.0222 0.1007
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0161 0.1533 0.1533
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0514
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.002 0.0045
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2266 0.2266
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi Bromodomain containing protein 0.0038 0.0299 0.0694
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.002 0.002
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0222 0.1007
Brugia malayi Serine/threonine protein phosphatase F56C9.1 in chromosomeIII 0.001 0.0015 0.0034
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0587 0.9898
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus granulosus histone lysine methyltransferase setb 0.0124 0.1162 0.1162
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0076
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0276 0.0276
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0031 0.0234 0.0234
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0155 0.0222
Brugia malayi Uncoordinated protein 44 0.0031 0.0233 0.054
Loa Loa (eye worm) uncoordinated protein 58 0.0038 0.0299 0.0299
Echinococcus granulosus potassium channel subfamily K 0.0038 0.0299 0.0299
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0222 0.0222
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0046 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Schistosoma mansoni protein phosphatase type 1 0.001 0.0015 0.0015
Loa Loa (eye worm) RNA binding protein 0.0063 0.0548 0.0548
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0044 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0034 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Onchocerca volvulus 0.0038 0.0299 0.0651
Echinococcus multilocularis protein phosphatase 1 catalytic subunit 0.001 0.0015 0.0015
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0222
Mycobacterium ulcerans beta-lactamase 0.0036 0.0277 0.3649
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.002 0.0045
Brugia malayi Sugar transporter family protein 0.003 0.0222 0.0514
Echinococcus granulosus General substrate transporter 0.0184 0.1768 0.1768
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus multilocularis potassium channel subfamily K 8 0.0038 0.0299 0.0299
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Onchocerca volvulus 0.0038 0.0299 0.0651
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0222 0.0686
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0911 0.0911
Onchocerca volvulus 0.0038 0.0299 0.0651
Mycobacterium tuberculosis Conserved protein 0.0036 0.0277 0.0943
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0276 0.0276
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.002 0.002
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0067 0.0592 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.1257
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0592 0.5904
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 1
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0284 0.4662
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 0.2555
Echinococcus multilocularis General substrate transporter 0.0184 0.1768 0.1768
Schistosoma mansoni glucose transport protein 0.0214 0.2071 0.2071
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0038 0.0299 0.0693
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0018 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.002 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.1162 0.1162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.002 0.002
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0155 0.0358
Echinococcus granulosus tar DNA binding protein 0.0063 0.0548 0.0548
Brugia malayi Death domain containing protein 0.0031 0.0233 0.054
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0222 0.0222
Trypanosoma cruzi hexose transporter 0.0066 0.0587 0.9898
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0038 0.0299 0.0693
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0128 0.1958
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0233 0.0497
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0076 0.0076
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.001 0.0015 0.0015
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0592 1
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0067 0.0592 0.281
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.036 0.5976
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0067 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Schistosoma mansoni cpg binding protein 0.0032 0.0239 0.0239
Echinococcus granulosus serine:threonine protein phosphatase PP1 gamma 0.001 0.0015 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.4692
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0076 0.0176
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0277 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0277 0.0943
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0038 0.0299 0.1049
Echinococcus granulosus serine:threonine protein phosphatase PP1 beta 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0277 0.1274
Brugia malayi isocitrate dehydrogenase 0.0016 0.0076 0.0176
Leishmania major calcium/potassium channel (CAKC), putative 0.0038 0.0299 0.4921
Schistosoma mansoni cpg binding protein 0.0028 0.0204 0.0204
Echinococcus granulosus potassium channel subfamily K 8 0.0038 0.0299 0.0299
Echinococcus multilocularis cpg binding protein 0.0032 0.0239 0.0239
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0339 0.0339
Toxoplasma gondii ion channel protein 0.0038 0.0299 0.1383
Loa Loa (eye worm) runx1 0.0055 0.0471 0.0471
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Mycobacterium ulcerans transmembrane cation transporter 0.0038 0.0299 0.41
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0277 0.3649
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Onchocerca volvulus 0.0028 0.0204 0.043
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.036 0.1528
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0548 0.0548
Echinococcus multilocularis serine:threonine protein phosphatase PP1 beta 0.001 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.001 0.002 0.002
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Schistosoma mansoni thyroid hormone receptor 0.001 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0032 0.0239 0.0239
Plasmodium vivax hexose transporter 0.0214 0.2071 1
Brugia malayi Sugar transporter family protein 0.003 0.0222 0.0514
Leishmania major hypothetical protein, conserved 0.0038 0.0299 0.4921
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0085 0.0044
Schistosoma mansoni glucose transport protein 0.0214 0.2071 0.2071
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus multilocularis potassium channel subfamily K 0.0038 0.0299 0.0299
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0038 0.0299 0.1948
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.6767 0.6767
Loa Loa (eye worm) hypothetical protein 0.0044 0.0359 0.0359
Onchocerca volvulus 0.003 0.0222 0.0471
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.1257
Schistosoma mansoni coup transcription factor 0.001 0.002 0.002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0038 0.0299 0.0693
Schistosoma mansoni hypothetical protein 0.004 0.0323 0.0323
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0222 0.0916
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0592 0.5904
Schistosoma mansoni hypothetical protein 0.0015 0.0071 0.0071
Plasmodium vivax SET domain protein, putative 0.003 0.0222 0.1007
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0299 0.4921
Schistosoma mansoni protein phosphatase-1 0.001 0.0015 0.0015
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Mycobacterium tuberculosis Conserved protein 0.0036 0.0277 0.0943
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0587 0.2529
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0277 0.0943
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2266 0.2266
Onchocerca volvulus 0.003 0.0222 0.0471
Brugia malayi PHD-finger family protein 0.0026 0.0183 0.0424
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0038 0.0299 0.0299
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0592 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0038 0.0299 0.0693
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0128 0.1958
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1991 0.1991
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0286 0.1318
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0076 0.1062
Mycobacterium leprae Probable lipase LipE 0.0036 0.0277 1
Schistosoma mansoni hypothetical protein 0.0048 0.0398 0.0398
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) hypothetical protein 0.0124 0.1162 0.1162
Schistosoma mansoni hypothetical protein 0.1004 1 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Echinococcus multilocularis serine:threonine protein phosphatase PP1 gamma 0.001 0.0015 0.0015
Schistosoma mansoni calcium-activated potassium channel 0.0038 0.0299 0.0299
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0277 0.1158
Trypanosoma brucei glucose transporter 2A 0.0066 0.0587 0.9898
Schistosoma mansoni hypothetical protein 0.0214 0.2071 0.2071
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0592 0.0592
Echinococcus multilocularis twik family of potassium channels 0.0038 0.0299 0.0299
Onchocerca volvulus 0.003 0.0222 0.0471
Echinococcus multilocularis protein dispatched 1 0.0048 0.0398 0.0398
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Loa Loa (eye worm) hypothetical protein 0.004 0.0324 0.0324
Onchocerca volvulus 0.0038 0.0299 0.0651
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.1257
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.002 0.0045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0592 0.0592
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0548 0.127
Brugia malayi CXXC zinc finger family protein 0.0028 0.0204 0.0473
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.1162 0.1162
Loa Loa (eye worm) hypothetical protein 0.0097 0.0896 0.0896
Schistosoma mansoni calcium-activated potassium channel 0.0599 0.5927 0.5927
Loa Loa (eye worm) hypothetical protein 0.0389 0.3824 0.3824
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0592 0.0592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0076 0.0076
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0222 0.2548
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0339 0.0339
Brugia malayi ecdysteroid receptor 0.001 0.002 0.0045
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0038 0.0299 0.0299
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Echinococcus multilocularis alkaline phosphatase 0.0161 0.1533 0.1533
Leishmania major glucose transporter, lmgt1 0.0066 0.0587 0.9898
Trypanosoma cruzi ion transport protein, putative 0.0038 0.0299 0.4921
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1316 0.1316
Plasmodium falciparum hexose transporter 0.0214 0.2071 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0051 0.0433 0.0433
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0286 0.1199
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0299 0.0299
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0548 0.0548
Echinococcus granulosus protein phosphatase 1, catalytic subunit, beta isozyme 0.001 0.0015 0.0015
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0038 0.0299 0.4921
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0155 0.1196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Onchocerca volvulus 0.0036 0.0277 0.0598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0592 0.5904
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.002 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.002 0.002
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.3978 0.3978
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0222
Echinococcus granulosus calcium activated potassium channel variant 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0209 0.2022 0.2022
Loa Loa (eye worm) hypothetical protein 0.0368 0.3613 0.3613
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 0.2555
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Leishmania major hypothetical protein, conserved 0.0015 0.0071 0.0976
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0038 0.0299 0.4921
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0247 0.0806
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0404 0.3978 0.3978
Loa Loa (eye worm) hypothetical protein 0.0049 0.0414 0.0414
Schistosoma mansoni calcium-activated potassium channel 0.0038 0.0299 0.0299
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0286 0.3835
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0001 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0076 0.0298
Echinococcus granulosus GPCR family 2 0.0016 0.0076 0.0076
Brugia malayi beta-lactamase 0.0036 0.0277 0.0641
Onchocerca volvulus 0.003 0.0222 0.0471
Echinococcus granulosus cpg binding protein 0.0032 0.0239 0.0239
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0128 0.1958
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1316 0.1316
Echinococcus multilocularis small conductance calcium activated potassium 0.1004 1 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0192 0.1849 0.1849
Leishmania major hypothetical protein, conserved 0.0036 0.0277 0.4533
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi hypothetical protein 0.0038 0.0299 0.0693
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0155 0.0369
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0155 0.0358
Brugia malayi beta-lactamase family protein 0.0036 0.0277 0.0641
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0161 0.1533 0.1533
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0095 0.0391
Onchocerca volvulus 0.0036 0.0277 0.0598
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.002 0.0045
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0222 0.0686
Onchocerca volvulus 0.003 0.0222 0.0471
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0128 0.1958
Schistosoma mansoni hypothetical protein 0.004 0.0323 0.0323
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Brugia malayi Sugar transporter family protein 0.0214 0.2071 0.48
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0247 0.7662
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0592 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.0837 0.0837
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0896 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 0.2555
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0076 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.002 0.002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0286 0.1199
Echinococcus granulosus protein phosphatase 1 catalytic subunit 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0277
Echinococcus multilocularis potassium channel subfamily K 8 0.0038 0.0299 0.0299
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0038 0.0299 0.0693
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0277 0.0943
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0277 0.1158
Trypanosoma brucei sugar transporter, putative 0.003 0.0222 0.3585
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0204 0.0204
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.036 0.5976
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0038 0.0299 0.0693
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.1257
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.002 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.002 0.002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0076 0.0176
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Echinococcus multilocularis calcium activated potassium channel variant 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0233 0.0233
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Mycobacterium ulcerans ion transport protein 0.0038 0.0299 0.41
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0155 0.0358
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0286 0.177
Loa Loa (eye worm) hypothetical protein 0.0234 0.2266 0.2266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0535 0.0535
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0076 0.0076
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0038 0.0299 0.0693
Onchocerca volvulus 0.0235 0.2277 0.5257
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0067 0.0592 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0161 0.1537 0.1537
Toxoplasma gondii sugar transporter ST3 0.003 0.0222 0.1007
Leishmania major ion transport protein-like protein 0.0038 0.0299 0.4921
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0592 0.0592
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0286 0.4692
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0161 0.1533 0.1533
Onchocerca volvulus 0.003 0.0222 0.0471
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0277 0.0943
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0095 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0155 0.1196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.002 0.002
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0233 0.0233
Schistosoma mansoni inositol monophosphatase 0.0037 0.0286 0.0286
Plasmodium vivax potassium channel, putative 0.0038 0.0299 0.1383
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.0592 1
Echinococcus granulosus intestinal type alkaline phosphatase 0.0161 0.1533 0.1533
Loa Loa (eye worm) hypothetical protein 0.0034 0.0257 0.0257
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0076 0.0076
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) serine/threonine protein phosphatase PP1-beta catalytic subunit 0.001 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0031 0.0233 0.0233
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Echinococcus multilocularis GPCR, family 2 0.0016 0.0076 0.0076
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0222 0.3585
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0222 0.1007
Schistosoma mansoni calcium-activated potassium channel 0.1004 1 1
Echinococcus granulosus twik family of potassium channels 0.0038 0.0299 0.0299
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.6767 0.6767
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0592 0.2555
Schistosoma mansoni nuclear hormone receptor 0.001 0.002 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0277 0.0277
Brugia malayi TAR-binding protein 0.0063 0.0548 0.127
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0339 0.0339
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0896 0.0896
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0222
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0257 0.0597
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0155 0.2421
Trypanosoma brucei glucose transporter, putative 0.0066 0.0587 0.9898
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Onchocerca volvulus 0.003 0.0222 0.0471
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.036 0.5976
Echinococcus granulosus death domain containing protein 0.0031 0.0233 0.0233
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0222
Schistosoma mansoni protein phosphatase-1 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0277 0.1158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0192 0.1849 0.1849
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.002 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.002 0.0045
Brugia malayi nuclear receptor NHR-88 0.001 0.002 0.0045
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0214 0.2071 0.2071
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0277 0.0641
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0222
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0222 0.0222
Schistosoma mansoni zinc finger protein 0.0021 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0095 0.0095
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0587 0.9898
Echinococcus multilocularis twik family of potassium channels 0.0038 0.0299 0.0299
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0038 0.0299 0.0693
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0124 0.0124
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2202 1
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0147 0.1392 0.1392
Echinococcus granulosus dnaJ subfamily B 0.0404 0.3978 0.3978
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0339 0.1432
Trypanosoma cruzi hexose transporter, putative 0.003 0.0222 0.3585
Onchocerca volvulus 0.003 0.0222 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0076 0.0076
Echinococcus granulosus FTZ F1 alpha 0.001 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1104 0.1104
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0548 0.0548
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0128 0.1958
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0067 0.0592 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0159 0.0159
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0095 0.0391
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.002 0.002
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0038 0.0299 0.4921
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.002 0.002
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0592 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.002 0.002
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0299 0.1257
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0414 0.0959
Trypanosoma brucei calcium-activated potassium channel, putative 0.0038 0.0299 0.4921
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0587 0.9898
Schistosoma mansoni survival motor neuron protein 0.0048 0.0398 0.0398
Brugia malayi Serine/threonine protein phosphatase PP1-beta catalytic subunit 0.001 0.0015 0.0034
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Plasmodium falciparum potassium channel 0.0038 0.0299 0.1383
Echinococcus granulosus potassium channel subfamily K 8 0.0038 0.0299 0.0299
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0001 0.0001
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0592 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0494 0.2329
Echinococcus granulosus Ankyrin 0.0031 0.0234 0.0234
Leishmania major glucose transporter, lmgt2 0.0066 0.0587 0.9898
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0896 0.0896
Trypanosoma cruzi ISWI complex protein 0.0015 0.0071 0.0976
Echinococcus multilocularis serine:threonine protein phosphatase PP1 isozyme 0.001 0.0015 0.0015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2071 0.2071
Brugia malayi MH2 domain containing protein 0.0118 0.1104 0.2559
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.002 0.0045
Plasmodium vivax potassium channel, putative 0.0038 0.0299 0.1383
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.036 0.036
Onchocerca volvulus 0.0036 0.0277 0.0598
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0067 0.0592 1
Onchocerca volvulus 0.0038 0.0299 0.0651
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0137 0.1299 0.1299
Brugia malayi hypothetical protein 0.0234 0.2266 0.5252
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1104 0.1104
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0038 0.0299 0.0693
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0438 0.4315 0.4315
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0137 0.1299 0.1299
Brugia malayi Steroid receptor seven-up type 2 0.001 0.002 0.0045
Schistosoma mansoni inositol monophosphatase 0.0037 0.0286 0.0286
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0076 0.0298
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0277 0.0277
Mycobacterium ulcerans hypothetical protein 0.0036 0.0277 0.3649
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0548 0.0548
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0277 0.0943
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0222 0.0222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0587 0.9898
Trypanosoma cruzi sugar transporter, putative 0.003 0.0222 0.3585
Onchocerca volvulus 0.0038 0.0299 0.0651
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0161 0.1533 0.1533
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0587 0.2529
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.1631 0.7148
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Brugia malayi RNA binding protein 0.0063 0.0548 0.127
Toxoplasma gondii sugar transporter ST2 0.003 0.0222 0.1007
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0222 0.0222
Brugia malayi hypothetical protein 0.0438 0.4315 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0076 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0587 0.2529
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0916
Brugia malayi steroid hormone receptor 0.001 0.002 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.002 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0038 0.0299 0.0299
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.7966 0.7966
Schistosoma mansoni netrin receptor unc5 0.0031 0.0233 0.0233
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0124 0.1162 0.1162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.002 0.002
Trypanosoma cruzi glucose transporter, putative 0.003 0.0222 0.3585
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0222
Toxoplasma gondii ABC1 family protein 0.0036 0.0277 0.1274
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.002 0.0045
Loa Loa (eye worm) TWK-28 protein 0.0038 0.0299 0.0299
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0076 0.1062
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0234 0.0234
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0159 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0277 0.1158

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 19.8 uM Antiproliferative activity against human HepG2 cells assessed as growth inhibition measured after 48 hrs by MTT assay ChEMBL. 23260578
IC50 (functional) > 50 uM Antiproliferative activity against human HCT116 cells assessed as growth inhibition measured after 48 hrs by MTT assay ChEMBL. 23260578

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23260578

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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