Detailed information for compound 1752918

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 698.772 | Formula: C37H45F3N4O6
  • H donors: 3 H acceptors: 4 LogP: 5.7 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H](N1C[C@@H](C)[C@H](OCCCC[C@H](Oc2c(C1=O)cc(cc2)NC(=O)Nc1ccc(cc1)C(F)(F)F)C)CN(C(=O)c1ccccc1)C)C
  • InChi: 1S/C37H45F3N4O6/c1-24-21-44(25(2)23-45)35(47)31-20-30(42-36(48)41-29-15-13-28(14-16-29)37(38,39)40)17-18-32(31)50-26(3)10-8-9-19-49-33(24)22-43(4)34(46)27-11-6-5-7-12-27/h5-7,11-18,20,24-26,33,45H,8-10,19,21-23H2,1-4H3,(H2,41,42,48)/t24-,25+,26-,33-/m1/s1
  • InChiKey: APBVAIRGVGPFOM-WTRZPYMOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0292 0.0262 0.1738
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.026 0.019 0.019
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0433 0.0573 0.0573
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0267 0.0205 0.0411
Schistosoma mansoni tyrosine kinase 0.2186 0.4461 0.9964
Echinococcus multilocularis tyrosine protein kinase csk 0.0882 0.157 0.157
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0229 0.0122 0.0687
Brugia malayi RE15519p 0.0402 0.0504 0.1131
Brugia malayi GnHR receptor homolog 0.0402 0.0504 0.1131
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0821 0.1435 1
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Echinococcus multilocularis kinase suppressor of Ras 1 0.0882 0.157 0.157
Schistosoma mansoni similar to Protein C20orf152 homolog 0.026 0.019 0.0393
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0882 0.157 0.157
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0402 0.0504 0.1131
Schistosoma mansoni apoptosis regulator bax 0.0693 0.115 0.2543
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus raf serine:threonine protein kinase 0.0882 0.157 0.157
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0402 0.0504 0.1097
Schistosoma mansoni amine GPCR 0.0402 0.0504 0.1097
Echinococcus multilocularis protein tyrosine kinase 0.0882 0.157 0.157
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0229 0.0122 0.0687
Brugia malayi SRC-1 0.2186 0.4461 1
Brugia malayi putative neuropeptide receptor NPR1 0.0402 0.0504 0.1131
Echinococcus multilocularis tyrosine protein kinase csk 0.0882 0.157 0.157
Trypanosoma cruzi cAMP response protein 1, putative 0.026 0.019 0.0647
Brugia malayi Tachykinin-like peptides receptor 99D 0.0402 0.0504 0.1131
Loa Loa (eye worm) TK protein kinase 0.2186 0.4461 0.8161
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Echinococcus multilocularis tyrosine kinase 0.2186 0.4461 0.4461
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0229 0.0122 0.0222
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2081 0.4228 0.7734
Echinococcus granulosus neuropeptide FF receptor 2 0.0402 0.0504 0.0504
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Onchocerca volvulus 0.0402 0.0504 0.0735
Trypanosoma cruzi cytochrome P450, putative 0.0333 0.0353 0.1286
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0882 0.157 0.3486
Trypanosoma brucei cAMP binding protein, putative 0.026 0.019 0.0378
Loa Loa (eye worm) protein kinase domain-containing protein 0.0882 0.157 0.2873
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Trypanosoma cruzi cytochrome P450, putative 0.0333 0.0353 0.1286
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0402 0.0504 0.0923
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0402 0.0504 0.0735
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0433 0.0573 0.1048
Loa Loa (eye worm) neuropeptide F receptor 0.0402 0.0504 0.0923
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0882 0.157 0.157
Onchocerca volvulus 0.0882 0.157 0.3232
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.156 0.3074 1
Loa Loa (eye worm) hypothetical protein 0.026 0.019 0.0348
Brugia malayi Tensin 0.1304 0.2504 0.5614
Trypanosoma brucei phospholipase A1, putative 0.0746 0.1269 0.2845
Trypanosoma brucei protein kinase A regulatory subunit 0.026 0.019 0.0378
Schistosoma mansoni neuropeptide f receptor 76f 0.0402 0.0504 0.1097
Schistosoma mansoni aspartate carbamoyltransferase 0.0186 0.0025 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0402 0.0504 0.0504
Mycobacterium ulcerans pyruvate carboxylase 0.0821 0.1435 1
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica tyrosin kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0229 0.0122 0.0687
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0292 0.0262 0.1062
Echinococcus granulosus kinase suppressor of Ras 1 0.0882 0.157 0.157
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.026 0.019 0.0647
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2186 0.4461 0.4461
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0882 0.157 0.3486
Trypanosoma cruzi protein kinase A regulatory subunit 0.026 0.019 0.0647
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0205 0.0426
Echinococcus granulosus epidermal growth factor receptor 0.129 0.2474 0.2474
Loa Loa (eye worm) TK/Met protein kinase 0.0882 0.157 0.2873
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0402 0.0504 0.0504
Echinococcus granulosus biogenic amine 5HT receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0402 0.0504 0.0504
Brugia malayi Tyrosine-protein kinase abl-1 0.2186 0.4461 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0402 0.0504 0.0923
Echinococcus granulosus orexin receptor type 2 0.0402 0.0504 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis somatostatin receptor 0.0402 0.0504 0.0504
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi protein-tyrosine kinase 0.2186 0.4461 1
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Echinococcus granulosus neuropeptides capa receptor 0.0402 0.0504 0.0504
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0889 0.1585 0.612
Schistosoma mansoni acetyl-CoA carboxylase 0.2156 0.4395 0.9817
Onchocerca volvulus 0.0882 0.157 0.3232
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0402 0.0504 0.0504
Onchocerca volvulus 0.0746 0.1269 0.2525
Echinococcus multilocularis integrin linked protein kinase 0.0882 0.157 0.157
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Echinococcus multilocularis g-protein coupled receptor 0.0402 0.0504 0.0504
Echinococcus granulosus tyrosine protein kinase ABL1 0.2186 0.4461 0.4461
Echinococcus granulosus cytochrome P450 2K1 0.0229 0.0122 0.0122
Schistosoma mansoni serine/threonine RGC 0.0882 0.157 0.3486
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0882 0.157 0.3486
Mycobacterium ulcerans hypothetical protein 0.026 0.019 0.117
Brugia malayi Tyrosine-protein kinase PR2 0.0882 0.157 0.352
Echinococcus granulosus protein kinase 0.0882 0.157 0.157
Toxoplasma gondii pyruvate carboxylase 0.0821 0.1435 0.3226
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0882 0.157 0.2873
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.026 0.019 0.0393
Brugia malayi Guanylyl cyclase protein 23 0.0882 0.157 0.352
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0292 0.0262 0.1676
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0433 0.0573 0.1518
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.026 0.019 0.019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0402 0.0504 0.1097
Echinococcus granulosus suppressor of cytokine signaling 6 0.1304 0.2504 0.2504
Echinococcus granulosus neuropeptide s receptor 0.0402 0.0504 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2186 0.4461 0.4461
Schistosoma mansoni hypothetical protein 0.026 0.019 0.0393
Echinococcus granulosus peptide allatostatin:somatostatin 0.0402 0.0504 0.0504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Brugia malayi Cyclic-nucleotide gated cation channel 0.0433 0.0573 0.1285
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus granulosus epidermal growth factor receptor 0.129 0.2474 0.2474
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0267 0.0205 0.0205
Brugia malayi Protein kinase domain containing protein 0.138 0.2673 0.5993
Schistosoma mansoni suppressor of cytokine signaling 0.1304 0.2504 0.5579
Loa Loa (eye worm) SH2 domain-containing protein 0.1304 0.2504 0.4581
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis neuropeptides capa receptor 0.0402 0.0504 0.0504
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0821 0.1435 1
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0402 0.0504 0.0504
Giardia lamblia Protein 21.1 0.0882 0.157 0.9974
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2156 0.4395 0.4395
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0229 0.0122 0.0222
Schistosoma mansoni signal transduction protein lnk-related 0.1304 0.2504 0.5579
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Plasmodium vivax tyrosine kinase-like protein, putative 0.0882 0.157 0.5068
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.026 0.019 0.0427
Leishmania major acetyl-CoA carboxylase, putative 0.2156 0.4395 1
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0889 0.1585 0.1585
Schistosoma mansoni tyrosine kinase 0.0408 0.0518 0.1127
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1304 0.2504 0.2504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi neuropeptide F receptor 0.0402 0.0504 0.1131
Loa Loa (eye worm) cytochrome P450 family protein 0.0333 0.0353 0.0646
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0882 0.157 0.157
Echinococcus granulosus serotonin receptor 0.0402 0.0504 0.0504
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2186 0.4461 0.9964
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.2012 0.4076 0.9136
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0882 0.157 0.157
Echinococcus granulosus neuropeptide receptor A26 0.0402 0.0504 0.0504
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1304 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.184 0.3693 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.026 0.019 0.0393
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus SH2 motif 0.1304 0.2504 0.2504
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.026 0.019 0.0378
Schistosoma mansoni nck2/grb4 0.1304 0.2504 0.5579
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Leishmania major hypothetical protein, conserved 0.026 0.019 0.0378
Schistosoma mansoni tyrosine kinase 0.2188 0.4465 0.9972
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus multilocularis hyperpolarization activated cyclic 0.0433 0.0573 0.0573
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.026 0.019 0.0393
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2156 0.4395 1
Loa Loa (eye worm) cytochrome P450 0.0229 0.0122 0.0224
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0229 0.0122 0.0687
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus serine:threonine protein kinase 3 0.0677 0.1114 0.1114
Echinococcus multilocularis growth factor receptor bound protein 2 0.1304 0.2504 0.2504
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Brugia malayi Immunoglobulin I-set domain containing protein 0.0882 0.157 0.352
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.1919 0.3869 0.8674
Echinococcus granulosus g-protein coupled receptor 0.0402 0.0504 0.0504
Schistosoma mansoni 60S ribosomal protein L21 0.0353 0.0398 0.0858
Echinococcus multilocularis tyrosine protein kinase Srms 0.2186 0.4461 0.4461
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis dro:myosuppressin receptor 0.0402 0.0504 0.0504
Echinococcus granulosus 7tm_1 domain containing protein 0.0402 0.0504 0.0504
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0882 0.157 0.4229
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0292 0.0262 0.0541
Brugia malayi G-protein coupled receptor 0.0402 0.0504 0.1131
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.026 0.019 0.0427
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0292 0.0262 0.0927
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.026 0.019 0.0393
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0882 0.157 0.157
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Loa Loa (eye worm) TK/CSK protein kinase 0.0882 0.157 0.2873
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0229 0.0122 0.038
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.026 0.019 0.0393
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Plasmodium falciparum cGMP-dependent protein kinase 0.0267 0.0205 0.0589
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni hypothetical protein 0.0882 0.157 0.3486
Leishmania major cyclic nucleotide-binding protein-like protein 0.026 0.019 0.0378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0402 0.0504 0.1097
Loa Loa (eye worm) hypothetical protein 0.1919 0.3869 0.7079
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0882 0.157 0.3232
Toxoplasma gondii STE kinase 0.0882 0.157 0.3536
Loa Loa (eye worm) hypothetical protein 0.2639 0.5466 1
Entamoeba histolytica tyrosin kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0433 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.2012 0.4076 0.4076
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Echinococcus granulosus integrin linked protein kinase 0.0882 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus granulosus tyrosine protein kinase 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus multilocularis calcium activated potassium channel 0.0179 0.0011 0.0011
Brugia malayi Dopamine receptor protein 1 0.0402 0.0504 0.1131
Onchocerca volvulus 0.2186 0.4461 1
Entamoeba histolytica hypothetical protein 0.0883 0.1572 0.3047
Trypanosoma brucei acetyl-CoA carboxylase 0.2156 0.4395 1
Echinococcus granulosus G protein coupled receptor 139 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0402 0.0504 0.1097
Schistosoma mansoni hypothetical protein 0.0402 0.0504 0.1097
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Onchocerca volvulus 0.0746 0.1269 0.2525
Onchocerca volvulus 0.0402 0.0504 0.0735
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0882 0.157 0.2873
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni pyruvate carboxylase 0.0821 0.1435 0.3183
Schistosoma mansoni voltage-gated potassium channel 0.0433 0.0573 0.1251
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0402 0.0504 0.0504
Loa Loa (eye worm) TK/ROR protein kinase 0.0882 0.157 0.2873
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.026 0.019 0.019
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0517 0.076 0.076
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0229 0.0122 0.0687
Loa Loa (eye worm) cyclin domain-containing protein 0.0517 0.076 0.139
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.026 0.019 0.0378
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0433 0.0573 0.0573
Echinococcus multilocularis tyrosine protein kinase HCK 0.0882 0.157 0.157
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni tyrosine kinase 0.2186 0.4461 0.9964
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Trypanosoma cruzi acetyl-CoA carboxylase 0.1335 0.2574 1
Echinococcus multilocularis epidermal growth factor receptor 0.129 0.2474 0.2474
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Mycobacterium tuberculosis Conserved hypothetical protein 0.026 0.019 0.0519
Brugia malayi STE20-like kinase MST 0.0677 0.1114 0.2498
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Schistosoma mansoni tyrosine kinase 0.129 0.2474 0.5512
Brugia malayi putative neuropeptide receptor 0.0402 0.0504 0.1131
Loa Loa (eye worm) TK/EPH protein kinase 0.0882 0.157 0.2873
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2186 0.4461 0.4461
Toxoplasma gondii cytochrome p450 superfamily protein 0.0229 0.0122 0.0222
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Entamoeba histolytica ankyrin repeat protein 0.0882 0.157 0.3044
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0433 0.0573 0.1251
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.026 0.019 0.0647
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis neuropeptide receptor 0.1777 0.3554 0.3554
Leishmania major regulatory subunit of protein kinase a-like protein 0.026 0.019 0.0378
Echinococcus granulosus growth factor receptor bound protein 2 0.1304 0.2504 0.2504
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0693 0.115 0.115
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.156 0.3074 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0882 0.157 0.157
Schistosoma mansoni protein kinase 0.0889 0.1585 0.3519
Echinococcus granulosus tm gpcr rhodopsin 0.0402 0.0504 0.0504
Echinococcus multilocularis SH2 domain containing protein 7 0.1304 0.2504 0.2504
Entamoeba histolytica hypothetical protein 0.0885 0.1577 0.306
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0229 0.0122 0.0687
Schistosoma mansoni voltage-gated potassium channel 0.0614 0.0974 0.215
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi Immunoglobulin I-set domain containing protein 0.0882 0.157 0.352
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0229 0.0122 0.038
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0882 0.157 0.157
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Onchocerca volvulus 0.0402 0.0504 0.0735
Brugia malayi cytokine inducible SH2-containing protein 5 0.1304 0.2504 0.5614
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1787 0.3577 0.3577
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) CYP4Cod1 0.0333 0.0353 0.0646
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni hypothetical protein 0.0402 0.0504 0.1097
Schistosoma mansoni tyrosine kinase 0.0408 0.0518 0.1127
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.026 0.019 0.0477
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0882 0.157 0.3536
Onchocerca volvulus 0.1304 0.2504 0.5418
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Schistosoma mansoni biogenic amine receptor 0.0402 0.0504 0.1097
Echinococcus granulosus voltage gated potassium channel 0.0614 0.0974 0.0974
Schistosoma mansoni tyrosine kinase 0.129 0.2474 0.5512
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0292 0.0262 0.1676
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus granulosus tyrosine kinase 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi sulfakinin receptor protein 0.0402 0.0504 0.1131
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Schistosoma mansoni growth hormone secretagogue receptor 0.0402 0.0504 0.1097
Brugia malayi N-terminal motif family protein 0.026 0.019 0.0427
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2186 0.4461 0.4461
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1304 0.2504 0.2504
Trichomonas vaginalis conserved hypothetical protein 0.026 0.019 0.0477
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.0258 0.0472
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus granulosus hypothetical protein 0.0402 0.0504 0.0504
Trichomonas vaginalis STE family protein kinase 0.0312 0.0305 0.079
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis neuropeptide receptor A26 0.0402 0.0504 0.0504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Onchocerca volvulus 0.0402 0.0504 0.0735
Schistosoma mansoni neuropeptide receptor 0.0402 0.0504 0.1097
Schistosoma mansoni adenoreceptor 0.0402 0.0504 0.1097
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0882 0.157 0.3044
Echinococcus multilocularis g protein coupled receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni tyrosine kinase 0.1787 0.3577 0.7984
Brugia malayi Cytochrome P450 family protein 0.0333 0.0353 0.0792
Schistosoma mansoni SH2A 0.1304 0.2504 0.5579
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0402 0.0504 0.0923
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Entamoeba histolytica SH2 domain containing protein 0.1304 0.2504 0.5291
Trichomonas vaginalis STE family protein kinase 0.0312 0.0305 0.079
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Brugia malayi integrin-linked kinase 0.0882 0.157 0.352
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1304 0.2504 0.5579
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.026 0.019 0.0393
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus tyrosine protein kinase shark 0.2188 0.4465 0.4465
Echinococcus multilocularis neuropeptide s receptor 0.0402 0.0504 0.0504
Schistosoma mansoni neuropeptide F-like receptor 0.0402 0.0504 0.1097
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Entamoeba histolytica protein kinase, putative 0.0883 0.1572 0.3047
Echinococcus multilocularis g protein coupled receptor 0.0402 0.0504 0.0504
Schistosoma mansoni biogenic amine (5HT) receptor 0.0402 0.0504 0.1097
Treponema pallidum cyclic nucleotide binding protein 0.026 0.019 0.5
Brugia malayi cytochrome P450 0.0229 0.0122 0.0274
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis tensin 0.1304 0.2504 0.2504
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Onchocerca volvulus 0.2186 0.4461 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0882 0.157 0.2873
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.026 0.019 0.0519
Loa Loa (eye worm) TK/ABL protein kinase 0.2186 0.4461 0.8161
Schistosoma mansoni serine/threonine protein kinase 0.0882 0.157 0.3486
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0229 0.0122 0.038
Plasmodium falciparum protein kinase, putative 0.0882 0.157 0.5068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Echinococcus multilocularis tyrosine protein kinase 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0292 0.0262 0.1738
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0402 0.0504 0.1131
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0186 0.0025 0.0024
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0821 0.1435 0.1435
Echinococcus multilocularis activin receptor type 0.0889 0.1585 0.1585
Schistosoma mansoni alpha-1 adrenergic receptor 0.0402 0.0504 0.1097
Echinococcus granulosus tyrosine protein kinase csk 0.0882 0.157 0.157
Echinococcus multilocularis signal transduction protein lnk realted 0.1304 0.2504 0.2504
Brugia malayi Protein kinase domain containing protein 0.0367 0.0427 0.0958
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0882 0.157 0.352
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni voltage-gated potassium channel 0.2193 0.4477 1
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Echinococcus granulosus tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Loa Loa (eye worm) hypothetical protein 0.0433 0.0573 0.1048
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus multilocularis patatin phospholipase domain containing protein 0.026 0.019 0.019
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1304 0.2504 0.2504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus tachykinin peptides receptor 99D 0.0402 0.0504 0.0504
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.026 0.019 0.0477
Echinococcus multilocularis FL cytokine receptor 0.0882 0.157 0.157
Echinococcus multilocularis tyrosine protein kinase csk 0.0882 0.157 0.157
Schistosoma mansoni hypothetical protein 0.1304 0.2504 0.5579
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0882 0.157 0.3486
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Schistosoma mansoni tyrosine kinase 0.2186 0.4461 0.9964
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni neuropeptide receptor 0.0402 0.0504 0.1097
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0433 0.0573 0.1251
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0433 0.0573 0.1251
Onchocerca volvulus 0.1304 0.2504 0.5418
Mycobacterium ulcerans hypothetical protein 0.026 0.019 0.117
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Onchocerca volvulus 0.1304 0.2504 0.5418
Schistosoma mansoni hypothetical protein 0.0229 0.0122 0.0241
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0186 0.0025 0.0024
Schistosoma mansoni protein kinase 0.0884 0.1574 0.3494
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0746 0.1269 0.2321
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus granulosus alpha 1A adrenergic receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0402 0.0504 0.0504
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.026 0.019 0.0519
Onchocerca volvulus 0.0402 0.0504 0.0735
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0229 0.0122 0.0687
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0292 0.0262 0.0662
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0402 0.0504 0.1097
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0433 0.0573 0.0573
Schistosoma mansoni amine GPCR 0.0402 0.0504 0.1097
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0402 0.0504 0.1097
Onchocerca volvulus 0.1304 0.2504 0.5418
Echinococcus granulosus g protein coupled receptor 0.0402 0.0504 0.0504
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus receptor type guanylyl cyclase 0.0882 0.157 0.157
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.026 0.019 0.019
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0821 0.1435 0.3226
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Echinococcus multilocularis serotonin receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Entamoeba histolytica hypothetical protein 0.0883 0.1572 0.3047
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1304 0.2504 0.2504
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.026 0.019 0.0378
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus biogenic amine 5HT receptor 0.0402 0.0504 0.0504
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0882 0.157 0.157
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0402 0.0504 0.0923
Onchocerca volvulus 0.0402 0.0504 0.0735
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0614 0.0974 0.2184
Echinococcus multilocularis SH2 motif 0.1304 0.2504 0.2504
Brugia malayi larval opioid receptor 0.0402 0.0504 0.1131
Schistosoma mansoni tyrosine kinase 0.129 0.2474 0.5512
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Echinococcus granulosus 7TM GPCR rhodopsin 0.0402 0.0504 0.0504
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0402 0.0504 0.0923
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.026 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni biogenic amine (5HT) receptor 0.0402 0.0504 0.1097
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) SRC-1 0.2186 0.4461 0.8161
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.026 0.019 0.0477
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0402 0.0504 0.1097
Leishmania major hypothetical protein, conserved 0.026 0.019 0.0378
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0882 0.157 0.157
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.026 0.019 0.0519
Echinococcus granulosus tm gpcr rhodopsin 0.0402 0.0504 0.0504
Schistosoma mansoni growth factor receptor-bound protein 0.1304 0.2504 0.5579
Echinococcus granulosus c src tyrosine kinase 0.2186 0.4461 0.4461
Schistosoma mansoni g1/s-specific cyclin C 0.1041 0.1923 0.4276
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Echinococcus multilocularis tyrosine protein kinase pr2 0.0882 0.157 0.157
Echinococcus granulosus protein tyrosine kinase 0.0882 0.157 0.157
Echinococcus multilocularis receptor type guanylyl cyclase 0.0882 0.157 0.157
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni tensin 0.1304 0.2504 0.5579
Echinococcus granulosus hypothetical protein 0.1304 0.2504 0.2504
Leishmania major cytochrome p450-like protein 0.0229 0.0122 0.0222
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0402 0.0504 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis neuropeptide FF receptor 2 0.0402 0.0504 0.0504
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0402 0.0504 0.0923
Echinococcus multilocularis raf serine:threonine protein kinase 0.0882 0.157 0.157
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Schistosoma mansoni hypothetical protein 0.0693 0.115 0.2543
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni ephrin receptor 0.0882 0.157 0.3486
Schistosoma mansoni voltage-gated potassium channel 0.2193 0.4477 1
Leishmania major protein kinase, putative 0.0267 0.0205 0.0411
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0821 0.1435 0.3183
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.026 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis sex peptide receptor 0.0402 0.0504 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.026 0.019 0.0647
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0333 0.0353 0.2326
Schistosoma mansoni serine/threonine protein kinase 0.0817 0.1426 0.3164
Echinococcus granulosus cGMP dependent protein kinase 1 0.0267 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Mycobacterium ulcerans transmembrane transport protein 0.026 0.019 0.117
Onchocerca volvulus 0.0882 0.157 0.3232
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus granulosus NCK adaptor protein 0.1304 0.2504 0.2504
Echinococcus granulosus suppressor of cytokine signaling 7 0.1304 0.2504 0.2504
Loa Loa (eye worm) STAT protein 0.1304 0.2504 0.4581
Brugia malayi Variant SH3 domain containing protein 0.1304 0.2504 0.5614
Brugia malayi C-terminal src kinase protein 1 0.0882 0.157 0.352
Onchocerca volvulus 0.0402 0.0504 0.0735
Schistosoma mansoni serine/threonine protein kinase 0.0882 0.157 0.3486
Onchocerca volvulus 0.2186 0.4461 1
Plasmodium vivax protein kinase, putative 0.0882 0.157 0.5068
Echinococcus granulosus tyrosine protein kinase Blk 0.2186 0.4461 0.4461
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Echinococcus granulosus fmrfamide receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0433 0.0573 0.1048
Onchocerca volvulus 0.0402 0.0504 0.0735
Schistosoma mansoni tensin-related 0.1304 0.2504 0.5579
Echinococcus multilocularis serine threonine protein kinase 0.0312 0.0305 0.0305
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.026 0.019 0.0427
Trypanosoma cruzi protein kinase, putative 0.0882 0.157 0.6062
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0229 0.0122 0.0687
Schistosoma mansoni ste20-related kinase 0.0522 0.0771 0.1695
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0181 0.0015 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.2012 0.4076 0.4076
Echinococcus multilocularis G protein coupled receptor 139 0.1777 0.3554 0.3554
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Brugia malayi Dopamine receptor protein 2 0.0402 0.0504 0.1131
Schistosoma mansoni tensin 0.1304 0.2504 0.5579
Leishmania major protein kinase A regulatory subunit, putative 0.026 0.019 0.0378
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0292 0.0262 0.0553
Brugia malayi Cytochrome P450 family protein 0.0229 0.0122 0.0274
Echinococcus granulosus neuropeptide receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) RGC/RGC protein kinase 0.0882 0.157 0.2873
Echinococcus multilocularis allatostatin A receptor 0.0402 0.0504 0.0504
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0882 0.157 0.3232
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0517 0.076 0.076
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0889 0.1585 0.3569
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0882 0.157 0.4229
Schistosoma mansoni opsin-like receptor 0.0402 0.0504 0.1097
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.026 0.019 0.0541
Brugia malayi hypothetical protein 0.1304 0.2504 0.5614
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Echinococcus multilocularis insulin receptor 0.1787 0.3577 0.3577
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0342 0.0373 0.1363
Echinococcus multilocularis SH2 motif 0.1304 0.2504 0.2504
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0746 0.1269 0.2844
Schistosoma mansoni opsin-like receptor 0.0402 0.0504 0.1097
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0292 0.0262 0.1676
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus tyrosine protein kinase csk 0.0882 0.157 0.157
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Entamoeba histolytica receptor protein kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0614 0.0974 0.0974
Echinococcus multilocularis serotonin receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0882 0.157 0.157
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0882 0.157 0.352
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.026 0.019 0.0393
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1304 0.2504 0.2504
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0292 0.0262 0.0541
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0229 0.0122 0.0687
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0433 0.0573 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0205 0.0426
Leishmania major protein kinase, putative 0.0889 0.1585 0.3569
Loa Loa (eye worm) TYRA-2 protein 0.0402 0.0504 0.0923
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0229 0.0122 0.0687
Brugia malayi Cyclin, N-terminal domain containing protein 0.0517 0.076 0.1704
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1304 0.2504 0.4581
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0402 0.0504 0.0504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Brugia malayi Raf kinase 0.0882 0.157 0.352
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2186 0.4461 0.4461
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.026 0.019 0.0393
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0402 0.0504 0.1131
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) G-protein coupled receptor 0.0402 0.0504 0.0923
Onchocerca volvulus 0.0882 0.157 0.3232
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Brugia malayi Receptor family ligand binding region containing protein 0.0882 0.157 0.352
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0882 0.157 0.157
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1304 0.2504 0.2504
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0292 0.0262 0.1676
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0402 0.0504 0.0504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus granulosus cyclin dependent kinase 19 0.0817 0.1426 0.1426
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0614 0.0974 0.0974
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Onchocerca volvulus 0.2186 0.4461 1
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0292 0.0262 0.0541
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Treponema pallidum catabolite gene activator 0.026 0.019 0.5
Brugia malayi AKH receptor 0.0402 0.0504 0.1131
Loa Loa (eye worm) hypothetical protein 0.2639 0.5466 1
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Brugia malayi Protein kinase domain containing protein 0.0817 0.1426 0.3198
Loa Loa (eye worm) TK/DDR protein kinase 0.0882 0.157 0.2873
Trypanosoma cruzi cAMP binding protein, putative 0.026 0.019 0.0647
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus signal transduction protein lnk realted 0.1304 0.2504 0.2504
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Onchocerca volvulus 0.2186 0.4461 1
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis expressed conserved protein 0.0267 0.0205 0.0205
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.2156 0.4395 0.4395
Brugia malayi Cytochrome P450 family protein 0.0723 0.1218 0.273
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Plasmodium falciparum tyrosine kinase-like protein 0.0882 0.157 0.5068
Echinococcus granulosus g protein coupled receptor 0.0402 0.0504 0.0504
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0402 0.0504 0.0504
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1304 0.2504 0.2504
Echinococcus granulosus sex peptide receptor 0.0402 0.0504 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Echinococcus multilocularis SHC transforming protein 3 0.1304 0.2504 0.2504
Echinococcus granulosus insulin receptor 0.1787 0.3577 0.3577
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) TK/ACK protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0882 0.157 0.3536
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0292 0.0262 0.0927
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0882 0.157 0.157
Loa Loa (eye worm) SH2 domain-containing protein 0.1304 0.2504 0.4581
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Brugia malayi Protein kinase domain containing protein 0.2186 0.4461 1
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0433 0.0573 0.1251
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0882 0.157 0.157
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis hyperpolarization activated cyclic 0.0433 0.0573 0.0573
Echinococcus granulosus cyclin 0.0517 0.076 0.076
Brugia malayi G protein-coupled receptor 0.0402 0.0504 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Schistosoma mansoni tensin-related 0.1304 0.2504 0.5579
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1787 0.3577 0.3577
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0402 0.0504 0.0504
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0368 0.0429 0.1726
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Brugia malayi neuropeptide F receptor 0.0402 0.0504 0.1131
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0882 0.157 0.157
Echinococcus granulosus N chimaerin 0.1304 0.2504 0.2504
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Trypanosoma cruzi phospholipase A1, putative 0.0746 0.1269 0.4879
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2186 0.4461 0.4461
Echinococcus granulosus retinal guanylyl cyclase 2 0.0882 0.157 0.157
Schistosoma mansoni tensin 0.1304 0.2504 0.5579
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Loa Loa (eye worm) gastrulation defective protein 1 0.0811 0.1412 0.2583
Echinococcus multilocularis fmrfamide receptor 0.0402 0.0504 0.0504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0402 0.0504 0.1097
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0229 0.0122 0.0687
Loa Loa (eye worm) SH2 domain-containing protein 0.1304 0.2504 0.4581
Brugia malayi SH2 domain containing protein 0.2186 0.4461 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0267 0.0205 0.0205
Leishmania major cytochrome p450-like protein 0.0333 0.0353 0.075
Entamoeba histolytica protein kinase domain containing protein 0.0889 0.1585 0.3079
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Leishmania major carboxylase, putative 0.0821 0.1435 0.3226
Loa Loa (eye worm) cyclin C 0.1041 0.1923 0.3518
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Echinococcus granulosus activated cdc42 kinase 1 0.0882 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0693 0.115 0.2543
Schistosoma mansoni serine/threonine protein kinase 0.0882 0.157 0.3486
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0402 0.0504 0.1131
Onchocerca volvulus 0.1304 0.2504 0.5418
Schistosoma mansoni neuropeptide receptor 0.0402 0.0504 0.1097
Brugia malayi Cytochrome P450 family protein 0.0333 0.0353 0.0792
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.026 0.019 0.0378
Loa Loa (eye worm) hypothetical protein 0.0497 0.0717 0.1311
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Toxoplasma gondii protein kinase domain-containing protein 0.0882 0.157 0.3536
Entamoeba histolytica SH2-protein kinase domain containing protein 0.131 0.2519 0.5327
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0433 0.0573 0.0573
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0312 0.0305 0.0559
Loa Loa (eye worm) hypothetical protein 0.026 0.019 0.0348
Loa Loa (eye worm) cytochrome P450 family protein 0.0333 0.0353 0.0646
Echinococcus granulosus tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Echinococcus multilocularis 0.1304 0.2504 0.2504
Trichomonas vaginalis protein tyrosine kinase, putative 0.0882 0.157 0.4229
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Trichomonas vaginalis AGC family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis SH2 motif 0.1304 0.2504 0.2504
Echinococcus multilocularis activated cdc42 kinase 1 0.0882 0.157 0.157
Schistosoma mansoni amine GPCR 0.0402 0.0504 0.1097
Schistosoma mansoni hypothetical protein 0.0693 0.115 0.2543
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0367 0.0427 0.0782
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2186 0.4461 0.4461
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1304 0.2504 0.4581
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0229 0.0122 0.0687
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1304 0.2504 0.2504
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0882 0.157 0.4229
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0402 0.0504 0.1097
Schistosoma mansoni myosin xvIII 0.0402 0.0504 0.1097
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0882 0.157 0.2873
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0367 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Entamoeba histolytica protein kinase, putative 0.131 0.2519 0.5327
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.026 0.019 0.0393
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.026 0.019 0.0519
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.026 0.019 0.0378
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Onchocerca volvulus 0.0882 0.157 0.3232
Onchocerca volvulus 0.0882 0.157 0.3232
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0883 0.1572 0.3047
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.026 0.019 0.0378
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) TK/ALK protein kinase 0.0882 0.157 0.2873
Brugia malayi STAT protein, DNA binding domain containing protein 0.1304 0.2504 0.5614
Schistosoma mansoni voltage-gated potassium channel 0.0353 0.0398 0.0858
Brugia malayi SH2 domain containing protein 0.2186 0.4461 1
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trypanosoma cruzi protein kinase, putative 0.0882 0.157 0.6062
Loa Loa (eye worm) hypothetical protein 0.2186 0.4461 0.8161
Leishmania major cytochrome p450-like protein 0.0229 0.0122 0.0222
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1304 0.2504 0.4581
Echinococcus granulosus cyclic nucleotide gated cation channel 0.026 0.019 0.019
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0229 0.0122 0.0687
Onchocerca volvulus 0.0402 0.0504 0.0735
Loa Loa (eye worm) RGC/RGC protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Giardia lamblia Kinase, NEK 0.0884 0.1574 1
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.026 0.019 0.0348
Schistosoma mansoni vav2 0.1304 0.2504 0.5579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Loa Loa (eye worm) TK/RYK protein kinase 0.0882 0.157 0.2873
Trypanosoma brucei cAMP response protein 1, putative 0.026 0.019 0.0378
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0882 0.157 0.352
Trypanosoma brucei Pseudokinase, putative 0.0882 0.157 0.3536
Treponema pallidum cyclic nucleotide binding protein 0.026 0.019 0.5
Onchocerca volvulus 0.2186 0.4461 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0882 0.157 0.157
Echinococcus multilocularis ephrin type A receptor 4 A 0.0882 0.157 0.157
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.026 0.019 0.0477
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0342 0.0373 0.1363
Schistosoma mansoni protein kinase 0.0889 0.1585 0.3519
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) neuropeptide F receptor 0.0402 0.0504 0.0923
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Trypanosoma brucei Flagellar Member 6 0.026 0.019 0.0378
Loa Loa (eye worm) AGC/PKG protein kinase 0.0267 0.0205 0.0375
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0882 0.157 0.2873
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Onchocerca volvulus 0.0402 0.0504 0.0735
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1304 0.2504 0.5418
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Brugia malayi Carboxyl transferase domain containing protein 0.2081 0.4228 0.9477
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1304 0.2504 0.2504
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0433 0.0573 0.1251
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Brugia malayi ORL1-like opioid receptor 0.0402 0.0504 0.1131
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2186 0.4461 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2186 0.4461 0.4461
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0889 0.1585 0.1585
Leishmania major protein kinase, putative 0.0267 0.0205 0.0411
Echinococcus granulosus allatostatin A receptor 0.0402 0.0504 0.0504
Schistosoma mansoni protein kinase 0.0889 0.1585 0.3519
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0402 0.0504 0.1097
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2156 0.4395 1
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0677 0.1114 0.2039
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus granulosus tyrosine protein kinase Src42A 0.1304 0.2504 0.2504
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1304 0.2504 0.2504
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0229 0.0122 0.0687
Entamoeba histolytica hypothetical protein, conserved 0.0882 0.157 0.3044
Onchocerca volvulus Neuropeptide F receptor homolog 0.0402 0.0504 0.0735
Brugia malayi hypothetical protein 0.0882 0.157 0.352
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1304 0.2504 0.2504
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.026 0.019 0.0393
Schistosoma mansoni biogenic amine receptor 0.0402 0.0504 0.1097
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2186 0.4461 0.4461
Brugia malayi tRNA modification GTPase TrmE family protein 0.1304 0.2504 0.5614
Onchocerca volvulus 0.0882 0.157 0.3232
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Echinococcus multilocularis NCK adaptor protein 0.1304 0.2504 0.2504
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus granulosus SHC transforming protein 3 0.1304 0.2504 0.2504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Echinococcus granulosus g protein coupled receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) apoptosis regulator protein 0.1919 0.3869 0.7079
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Brugia malayi G-protein coupled receptor 0.0402 0.0504 0.1131
Echinococcus granulosus tyrosine protein kinase Lyn 0.2192 0.4476 0.4476
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2186 0.4461 0.4461
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Echinococcus multilocularis cyclin dependent kinase 19 0.0817 0.1426 0.1426
Brugia malayi Protein kinase domain containing protein 0.2186 0.4461 1
Brugia malayi Dopamine receptor 0.0402 0.0504 0.1131
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Brugia malayi Protein kinase domain containing protein 0.2186 0.4461 1
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.1423 0.1423
Schistosoma mansoni shc transforming protein 0.1304 0.2504 0.5579
Echinococcus multilocularis tyrosine protein kinase Abl 0.2186 0.4461 0.4461
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0882 0.157 0.3044
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0267 0.0205 0.0205
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1304 0.2504 0.5579
Loa Loa (eye worm) TK/EGFR protein kinase 0.129 0.2474 0.4527
Brugia malayi bone morphogenetic protein type 1 receptor 0.0882 0.157 0.352
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0402 0.0504 0.0504
Trypanosoma brucei unspecified product 0.054 0.0811 0.1798
Loa Loa (eye worm) G-protein coupled receptor 0.0402 0.0504 0.0923
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus activated cdc42 kinase 1 0.0882 0.157 0.157
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.129 0.2474 0.2474
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.4684 1 1
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0821 0.1435 1
Schistosoma mansoni suppressor of cytokine signaling 0.1304 0.2504 0.5579
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0821 0.1435 1
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Schistosoma mansoni protein tyrosine kinase 0.0882 0.157 0.3486
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni histamine h1 receptor 0.0402 0.0504 0.1097
Loa Loa (eye worm) RGC/RGC protein kinase 0.0882 0.157 0.2873
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0229 0.0122 0.0687
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Brugia malayi Variant SH3 domain containing protein 0.1304 0.2504 0.5614
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Schistosoma mansoni neuropeptide receptor 0.1777 0.3554 0.7932
Echinococcus granulosus tyrosine protein kinase csk 0.0882 0.157 0.157
Echinococcus multilocularis tyrosine protein kinase Blk 0.2186 0.4461 0.4461
Echinococcus multilocularis protein kinase 0.0882 0.157 0.157
Brugia malayi Variant SH3 domain containing protein 0.1304 0.2504 0.5614
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0229 0.0122 0.0687
Echinococcus multilocularis fmrfamide receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0402 0.0504 0.0504
Entamoeba histolytica tyrosin kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2186 0.4461 0.4461
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0292 0.0262 0.1062
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0882 0.157 0.157
Entamoeba histolytica receptor protein kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus granulosus tyrosine protein kinase Srms 0.2186 0.4461 0.4461
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1304 0.2504 0.2504
Trypanosoma cruzi Flagellar Member 6 0.026 0.019 0.0647
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0402 0.0504 0.1097
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0882 0.157 0.157
Brugia malayi ephrin receptor 1 precursor 0.0882 0.157 0.352
Echinococcus granulosus tyrosine kinase 0.2186 0.4461 0.4461
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0292 0.0262 0.1676
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0292 0.0262 0.0541
Echinococcus multilocularis transfer RNA-Thr 0.0882 0.157 0.157
Brugia malayi hypothetical protein 0.2186 0.4461 1
Mycobacterium ulcerans hypothetical protein 0.026 0.019 0.117
Entamoeba histolytica cysteine surface protein, putative 0.0882 0.157 0.3044
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1304 0.2504 0.2504
Entamoeba histolytica hypothetical protein 0.0883 0.1572 0.3047
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1304 0.2504 0.5579
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0889 0.1585 0.3569
Schistosoma mansoni tyrosine kinase 0.2186 0.4461 0.9964
Entamoeba histolytica tyrosin kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus fibroblast growth factor receptor 4 0.0882 0.157 0.157
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0229 0.0122 0.0687
Echinococcus multilocularis orexin receptor type 2 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0614 0.0974 0.1782
Echinococcus granulosus cGMP dependent protein kinase 0.0267 0.0205 0.0205
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.026 0.019 0.019
Schistosoma mansoni biogenic amine receptor 0.0402 0.0504 0.1097
Trichomonas vaginalis TK family protein kinase 0.0882 0.157 0.4229
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.026 0.019 0.0378
Echinococcus multilocularis protein KINase family member (kin 25) 0.0882 0.157 0.157
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1304 0.2504 0.5579
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0229 0.0122 0.0687
Treponema pallidum catabolite gene activator (Crp) 0.026 0.019 0.5
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0369 0.0433 0.0433
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0402 0.0504 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0205 0.0426
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Entamoeba histolytica ankyrin repeat protein 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Brugia malayi G protein-coupled receptor F59B2.13 0.0402 0.0504 0.1131
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni amine GPCR 0.0402 0.0504 0.1097
Echinococcus multilocularis tyrosine kinase 0.0882 0.157 0.157
Echinococcus granulosus neuropeptide Y receptor 0.0402 0.0504 0.0504
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) RGC/RGC protein kinase 0.0882 0.157 0.2873
Schistosoma mansoni ephrin receptor 0.0882 0.157 0.3486
Plasmodium falciparum protein kinase, putative 0.0889 0.1585 0.5116
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0187 0.0029 0.0009
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0882 0.157 0.2873
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus granulosus hyperpolarization activated cyclic 0.0433 0.0573 0.0573
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1304 0.2504 0.5579
Schistosoma mansoni tyrosine kinase 0.0408 0.0518 0.1127
Entamoeba histolytica cyclin C, putative 0.0524 0.0777 0.1134
Echinococcus granulosus hyperpolarization activated cyclic 0.0433 0.0573 0.0573
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni growth factor receptor-bound protein 0.1304 0.2504 0.5579
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0882 0.157 0.3536
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.2012 0.4076 0.7456
Schistosoma mansoni protein kinase 0.0882 0.157 0.3486
Echinococcus multilocularis tyrosine protein kinase csk 0.0882 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0312 0.0305 0.0919
Schistosoma mansoni protein kinase 0.0884 0.1574 0.3494
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1304 0.2504 0.5418
Trypanosoma brucei cytochrome P450, putative 0.0333 0.0353 0.075
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.026 0.019 0.0647
Echinococcus multilocularis epidermal growth factor receptor 0.129 0.2474 0.2474
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Echinococcus multilocularis neuropeptide Y receptor 0.0402 0.0504 0.0504
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.184 0.3693 1
Echinococcus multilocularis neuropeptides capa receptor 0.0402 0.0504 0.0504
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0693 0.115 0.115
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0821 0.1435 0.3226
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.026 0.019 0.019
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0821 0.1435 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Mycobacterium ulcerans regulatory protein 0.026 0.019 0.117
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trypanosoma brucei Flagellum attachment zone protein 20 0.0882 0.157 0.3536
Echinococcus granulosus neuropeptides capa receptor 0.0402 0.0504 0.0504
Mycobacterium ulcerans transcriptional regulatory protein 0.026 0.019 0.117
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0292 0.0262 0.1738
Mycobacterium tuberculosis Conserved protein 0.026 0.019 0.0519
Trypanosoma cruzi cAMP response protein 1 0.026 0.019 0.0647
Schistosoma mansoni amine GPCR 0.0402 0.0504 0.1097
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis c src tyrosine kinase 0.2186 0.4461 0.4461
Giardia lamblia Kinase, NEK 0.0882 0.157 0.9974
Schistosoma mansoni GTPase activating protein 0.1304 0.2504 0.5579
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1304 0.2504 0.4581
Echinococcus granulosus tyrosine protein kinase Src64B 0.2186 0.4461 0.4461
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0292 0.0262 0.0262
Loa Loa (eye worm) TK/FAK protein kinase 0.0882 0.157 0.2873
Brugia malayi Serotonin receptor 0.0402 0.0504 0.1131
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0229 0.0122 0.0687
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1304 0.2504 0.4581
Echinococcus granulosus neuropeptide Y receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Loa Loa (eye worm) hypothetical protein 0.1304 0.2504 0.4581
Trichomonas vaginalis TKL family protein kinase 0.0885 0.1577 0.4247
Echinococcus granulosus SH2 motif 0.1304 0.2504 0.2504
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0292 0.0262 0.1676
Loa Loa (eye worm) TK/INSR protein kinase 0.1787 0.3577 0.6544
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.0305 0.0651
Echinococcus multilocularis G-protein coupled receptor, putative 0.0402 0.0504 0.0504
Brugia malayi Pax transcription factor protein 2 0.0291 0.0258 0.0579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Brugia malayi follicle stimulating hormone receptor 0.0402 0.0504 0.1131
Brugia malayi RhoGAP domain containing protein 0.1304 0.2504 0.5614
Loa Loa (eye worm) hypothetical protein 0.1752 0.3499 0.6401
Echinococcus granulosus dro:myosuppressin receptor 0.0402 0.0504 0.0504
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Echinococcus granulosus calcium activated potassium channel 0.0179 0.0011 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi Serotonin receptor 0.0402 0.0504 0.1131
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis protein kinase atn1, putative 0.0882 0.157 0.4229
Schistosoma mansoni adapter molecule crk 0.1304 0.2504 0.5579
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Echinococcus multilocularis neuropeptide receptor 0.0402 0.0504 0.0504
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0821 0.1435 0.5531
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0821 0.1435 0.3226
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0882 0.157 0.352
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Mycobacterium ulcerans hypothetical protein 0.026 0.019 0.117
Brugia malayi Variant SH3 domain containing protein 0.1304 0.2504 0.5614
Echinococcus multilocularis natriuretic peptide receptor 1 0.0882 0.157 0.157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0402 0.0504 0.1097
Schistosoma mansoni serine/threonine protein kinase 0.0882 0.157 0.3486
Onchocerca volvulus 0.1304 0.2504 0.5418
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0882 0.157 0.157
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Schistosoma mansoni neuropeptide F-like receptor 0.0402 0.0504 0.1097
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0882 0.157 0.3486
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0821 0.1435 0.3183
Onchocerca volvulus 0.0402 0.0504 0.0735
Brugia malayi Protein kinase domain containing protein 0.1787 0.3577 0.8019
Brugia malayi Protein kinase domain containing protein 0.0882 0.157 0.352
Echinococcus multilocularis tyrosine protein kinase shark 0.2188 0.4465 0.4465
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0292 0.0262 0.0927
Onchocerca volvulus 0.0882 0.157 0.3232
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0292 0.0262 0.1676
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Onchocerca volvulus 0.0291 0.0258 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0723 0.1218 0.2228
Brugia malayi Cyclin C 0.1041 0.1923 0.431
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0821 0.1435 0.5531
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni hypothetical protein 0.0402 0.0504 0.1097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0402 0.0504 0.1097
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trypanosoma cruzi phospholipase A1, putative 0.0746 0.1269 0.4879
Loa Loa (eye worm) TK/FER protein kinase 0.2186 0.4461 0.8161
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0882 0.157 0.157
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis conserved hypothetical protein 0.0882 0.157 0.4229
Echinococcus granulosus SH2 domain containing protein 7 0.1304 0.2504 0.2504
Trichomonas vaginalis STE family protein kinase 0.0882 0.157 0.4229
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0882 0.157 0.157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0402 0.0504 0.1131
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0882 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Schistosoma mansoni opsin-like receptor 0.0402 0.0504 0.1097
Schistosoma mansoni hypothetical protein 0.1304 0.2504 0.5579
Echinococcus multilocularis g protein coupled receptor 0.0402 0.0504 0.0504
Plasmodium vivax tyrosine kinase-like protein, putative 0.0882 0.157 0.5068
Echinococcus granulosus retinal guanylyl cyclase 2 0.0882 0.157 0.157
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Schistosoma mansoni tyrosine kinase 0.2186 0.4461 0.9964
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Echinococcus multilocularis voltage gated potassium channel 0.0614 0.0974 0.0974
Trypanosoma brucei protein kinase, putative 0.0889 0.1585 0.3569
Toxoplasma gondii protein kinase 0.0882 0.157 0.3536
Schistosoma mansoni tyrosine kinase 0.1787 0.3577 0.7984
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2186 0.4461 0.4461
Mycobacterium tuberculosis Conserved hypothetical protein 0.026 0.019 0.0519
Schistosoma mansoni tyrosine protein kinase 0.0882 0.157 0.3486
Echinococcus granulosus patatin phospholipase domain containing protein 0.026 0.019 0.019
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0821 0.1435 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.1304 0.2504 0.2504
Mycobacterium leprae Conserved hypothetical protein 0.0229 0.0122 0.0756
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0889 0.1585 0.612
Brugia malayi Melatonin receptor type 1A 0.0402 0.0504 0.1131
Echinococcus granulosus expressed conserved protein 0.1304 0.2504 0.2504
Entamoeba histolytica tyrosine kinase, putative 0.0882 0.157 0.3044
Leishmania major phospholipase A1, putative 0.0746 0.1269 0.2845
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Loa Loa (eye worm) hypothetical protein 0.0882 0.157 0.2873
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0882 0.157 0.2873
Leishmania major hypothetical protein, unknown function 0.026 0.019 0.0378
Echinococcus multilocularis neuropeptide Y receptor 0.0402 0.0504 0.0504
Onchocerca volvulus Tyrosine kinase homolog 0.0882 0.157 0.3232
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Leishmania major protein kinase, putative 0.0882 0.157 0.3536
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0821 0.1435 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0882 0.157 0.157
Echinococcus granulosus tyrosine protein kinase Src42A 0.2186 0.4461 0.4461
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.026 0.019 0.0393
Loa Loa (eye worm) TK/FER protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0882 0.157 0.2873
Giardia lamblia Kinase 0.0882 0.157 0.9974
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Echinococcus multilocularis 0.0229 0.0122 0.0122
Echinococcus granulosus tensin 0.1304 0.2504 0.2504
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Schistosoma mansoni tyrosine kinase 0.0882 0.157 0.3486
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.026 0.019 0.0541
Echinococcus granulosus somatostatin receptor 0.0402 0.0504 0.0504
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1304 0.2504 0.5614
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0229 0.0122 0.0687
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0882 0.157 0.4229
Echinococcus multilocularis heat shock protein 70 0.0882 0.157 0.157
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0882 0.157 0.3486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0402 0.0504 0.0504
Echinococcus granulosus tyrosine protein kinase Fyn 0.2186 0.4461 0.4461
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Mycobacterium leprae putative cytochrome p450 0.0229 0.0122 0.0756
Schistosoma mansoni voltage-gated potassium channel 0.0614 0.0974 0.215
Schistosoma mansoni cytochrome P450 0.0229 0.0122 0.0241
Plasmodium falciparum tyrosine kinase-like protein 0.0882 0.157 0.5068
Plasmodium falciparum protein kinase, putative 0.0882 0.157 0.5068
Echinococcus granulosus neuropeptide receptor 0.1777 0.3554 0.3554
Mycobacterium leprae Conserved hypothetical protein 0.026 0.019 0.1236
Brugia malayi Furin-like cysteine rich region family protein 0.129 0.2474 0.5547
Echinococcus granulosus tyrosine kinase 0.2186 0.4461 0.4461
Brugia malayi Sex muscle abnormal protein 5 0.1304 0.2504 0.5614
Schistosoma mansoni hypothetical protein 0.0693 0.115 0.2543
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus granulosus single minded 2 0.0181 0.0015 0.0015
Echinococcus granulosus activin receptor type 0.0889 0.1585 0.1585
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0368 0.0429 0.0298
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) TK protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis serine:threonine protein kinase 3 0.0677 0.1114 0.1114
Plasmodium falciparum protein kinase, putative 0.0312 0.0305 0.0919
Echinococcus multilocularis N chimaerin 0.1304 0.2504 0.2504
Onchocerca volvulus 0.0402 0.0504 0.0735
Echinococcus granulosus retinal guanylyl cyclase 2 0.0882 0.157 0.157
Brugia malayi hypothetical protein 0.0882 0.157 0.352
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Trichomonas vaginalis CAMK family protein kinase 0.0882 0.157 0.4229
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1304 0.2504 0.4581
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0817 0.1426 0.261
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0882 0.157 0.157
Brugia malayi Egg laying defective protein 4 0.0267 0.0205 0.0459
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.026 0.019 0.0541
Echinococcus multilocularis tensin 0.1304 0.2504 0.2504
Echinococcus granulosus rhodopsin orphan GPCR 0.0402 0.0504 0.0504
Echinococcus multilocularis cyclin 0.0517 0.076 0.076
Entamoeba histolytica protein kinase, putative 0.0882 0.157 0.3044
Echinococcus granulosus serine threonine protein kinase 0.0312 0.0305 0.0305
Brugia malayi Protein kinase domain containing protein 0.2186 0.4461 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0433 0.0573 0.1518
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0402 0.0504 0.1097
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0882 0.157 0.3044
Leishmania major hypothetical protein, conserved 0.0882 0.157 0.3536
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0433 0.0573 0.0573
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0882 0.157 0.2873
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923
Echinococcus multilocularis protein kinase 0.0882 0.157 0.157
Brugia malayi Protein kinase domain containing protein 0.2186 0.4461 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0882 0.157 0.157
Brugia malayi SH2 domain containing protein 0.1304 0.2504 0.5614
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0292 0.0262 0.0262
Chlamydia trachomatis biotin carboxylase 0.0746 0.1268 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0821 0.1435 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2186 0.4461 0.4461
Schistosoma mansoni hypothetical protein 0.0402 0.0504 0.1097
Onchocerca volvulus 0.0882 0.157 0.3232
Trichomonas vaginalis TKL family protein kinase 0.0882 0.157 0.4229
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0882 0.157 0.352
Entamoeba histolytica hypothetical protein 0.0882 0.157 0.3044
Brugia malayi hypothetical protein 0.0402 0.0504 0.1131
Onchocerca volvulus 0.0746 0.1269 0.2525
Leishmania major hypothetical protein, conserved 0.026 0.019 0.0378
Entamoeba histolytica protein kinase domain containing protein 0.0882 0.157 0.3044
Entamoeba histolytica serine/threonine kinase, putative 0.0882 0.157 0.3044
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0882 0.157 0.352
Loa Loa (eye worm) hypothetical protein 0.0402 0.0504 0.0923

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 6.57 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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