TDR Targets

Basic information

Technical information

TDR Targets ID: 178317
Name: 2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2- yl]heptanoic acid
MW: 358.537 | Formula: C22H30O2S
H donors: 1 H acceptors: 2 LogP: 6.88 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(CCCCCc1sccc1CCCc1ccccc1)(C)C
InChi: 1S/C22H30O2S/c1-22(2,21(23)24)16-8-4-7-14-20-19(15-17-25-20)13-9-12-18-10-5-3-6-11-18/h3,5-6,10-11,15,17H,4,7-9,12-14,16H2,1-2H3,(H,23,24)
InChiKey: QMXLXSYXJOJQSN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,2-dimethyl-7-[3-(3-phenylpropyl)-2-thienyl]heptanoic acid
2,2-dimethyl-7-[3-(3-phenylpropyl)-2-thienyl]enanthic acid
RP 66153
142422-79-5
2,2-Dimethyl-7-(3-(3-phenylpropyl)-2-thienyl)heptanoic acid
2-Thiopheneheptanoic acid, alpha,alpha-dimethyl-3-(3-phenylpropyl)
RP-66153

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leukotriene B4 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	metastasis associated protein 1 (mta1)	0.0031	0.0006	0.0005
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0512	0.0776	0.0775
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0512	0.0776	0.0775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4993	0.7945	0.7944
Schistosoma mansoni	hypothetical protein	0.0079	0.0083	0.0082
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0081	0.0085	0.0085
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Echinococcus multilocularis	conserved hypothetical protein	0.0709	0.1091	0.109
Schistosoma mansoni	metastasis-associated protein 1 (mta1)	0.0031	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0006	0.0006
Giardia lamblia	Hypothetical protein	0.0405	0.0604	0.06
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0119	0.0146	0.0145
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0242	0.0343	0.0342
Echinococcus multilocularis	mesoderm induction early response protein 1	0.0031	0.0006	0.0005
Onchocerca volvulus		0.0405	0.0604	0.3543
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0405	0.0604	0.0602
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.003	0.0004	0.0002
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.0446	0.0446
Schistosoma mansoni	hypothetical protein	0.0514	0.0778	0.0778
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0061	0.0053	0.0049
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0061	0.0053	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0389	0.0389
Echinococcus multilocularis	Zinc finger, PHD finger	0.0405	0.0604	0.0603
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0017	0.0001
Brugia malayi	nuclear hormone receptor	0.0242	0.0343	0.0342
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.6277	1	1
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0405	0.0604	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0477	0.0719	0.0718
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0405	0.0604	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0042	0.0042
Echinococcus multilocularis	fk506 binding protein	0.0061	0.0053	0.0052
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.0042	0.1795
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3751	0.5958	0.5956
Onchocerca volvulus		0.0155	0.0203	0.119
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0034	0.0011	0.001
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0072	0.0072	0.0242
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.6277	1	1
Trichomonas vaginalis	glutaminase, putative	0.028	0.0405	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0061	0.0053	0.0052
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0017	0.0015
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0512	0.0776	0.0775
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0016	0.0012
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0079	0.0083	0.0082
Schistosoma mansoni	zinc finger protein	0.0031	0.0006	0.0005
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0405	0.0604	0.06
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0405	0.0604	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0113
Mycobacterium leprae	conserved hypothetical protein	0.0405	0.0604	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	thyroid hormone receptor	0.0512	0.0776	0.0775
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0242	0.0343	0.0342
Treponema pallidum	sodium- and chloride- dependent transporter	0.0477	0.0719	1
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0061	0.0053	0.0174
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0405	0.0604	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0072	0.0072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0512	0.0776	0.0776
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0081	0.0085	0.0085
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0405	0.0604	0.06
Echinococcus multilocularis	sterol O acyltransferase 1	0.0213	0.0297	0.0296
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0072	0.1127
Echinococcus granulosus	RUN	0.0041	0.0022	0.0021
Toxoplasma gondii	histone lysine-specific demethylase	0.0164	0.0218	0.0291
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0324	0.0474	0.0474
Brugia malayi	steroid hormone receptor	0.0512	0.0776	0.0775
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0239	0.0339	0.1295
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.6277	1	1
Echinococcus multilocularis	nibrin	0.003	0.0004	0.0003
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0038	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0072	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0405	0.0604	0.0603
Mycobacterium tuberculosis	Possible oxidoreductase	0.0164	0.0218	0.0818
Toxoplasma gondii	ATPase, AAA family protein	0.003	0.0004	0.0003
Plasmodium falciparum	protoporphyrinogen oxidase	0.0164	0.0218	0.3585
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0061	0.0053	0.0049
Loa Loa (eye worm)	glutaminase	0.028	0.0405	0.0405
Mycobacterium ulcerans	monoamine oxidase	0.0164	0.0218	0.0762
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0017	0.0013
Schistosoma mansoni	immunophilin	0.0061	0.0053	0.0052
Trichomonas vaginalis	replication factor C large subunit, putative	0.003	0.0004	0.00000022677
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0072	0.0056
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.0011	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0512	0.0776	0.0776
Brugia malayi	hypothetical protein	0.0127	0.016	0.0159
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0242	0.0343	0.0343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4993	0.7945	0.7944
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0016	0.0012
Echinococcus granulosus	geminin	0.0514	0.0778	0.0778
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0405	0.0604	0.0603
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0512	0.0776	0.0775
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Brugia malayi	nuclear receptor RXR	0.0242	0.0343	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6277	1	1
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0002	0.0001
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2105	0.3324	0.3324
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0512	0.0776	0.0775
Onchocerca volvulus	Mesoderm induction early response 1 related homolog	0.0031	0.0006	0.0028
Schistosoma mansoni	nuclear hormone receptor	0.0242	0.0343	0.0342
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0251	0.0358	0.0358
Echinococcus granulosus	sterol O acyltransferase 1	0.0213	0.0297	0.0296
Loa Loa (eye worm)	inositol-1	0.0038	0.0017	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Schistosoma mansoni	rab6-interacting	0.0041	0.0022	0.0021
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0918	0.1425	0.1424
Echinococcus multilocularis	GPCR, family 2	0.0079	0.0083	0.0082
Loa Loa (eye worm)	phosphatidylinositol 3	0.0405	0.0604	0.0604
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2105	0.3324	0.3324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.1856	0.1852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3384	0.5371	0.5369
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0016	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3389	0.5379	0.5378
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0512	0.0776	0.0775
Echinococcus multilocularis	Glutaredoxin protein 5	0.0041	0.0021	0.002
Entamoeba histolytica	hypothetical protein	0.0405	0.0604	0.06
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0405	0.0604	0.0603
Loa Loa (eye worm)	GATA zinc finger family protein	0.0031	0.0006	0.0006
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0271	0.0389	0.0388
Echinococcus granulosus	voltage gated potassium channel	0.0034	0.0011	0.001
Brugia malayi	hypothetical protein	0.0242	0.0343	0.0342
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0016	0.0232
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0066	0.0061	0.0059
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.1619	0.2547	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0061	0.0053	0.0049
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0512	0.0776	0.0775
Schistosoma mansoni	rab6-interacting	0.0041	0.0022	0.0021
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0164	0.0218	0.3585
Entamoeba histolytica	acyl-coA synthetase, putative	0.0072	0.0072	0.0068
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0016	0.0015
Onchocerca volvulus		0.0041	0.0022	0.0122
Plasmodium falciparum	amino acid transporter, putative	0.0081	0.0085	0.1389
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0016	0.0015
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0405	0.0604	0.0603
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0072	0.0068
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0405	0.0604	0.0603
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0164	0.0218	0.0291
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0405	0.0604	0.06
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0072	0.0241
Loa Loa (eye worm)	phosphatidylinositol 3	0.0405	0.0604	0.0604
Echinococcus granulosus	nibrin	0.003	0.0004	0.0003
Echinococcus multilocularis	snurportin 1	0.0306	0.0446	0.0445
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0072	0.0056
Schistosoma mansoni	lipoxygenase	0.0181	0.0246	0.0245
Trypanosoma brucei	RNA helicase, putative	0.0115	0.014	0.0138
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0016	0.0198
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0405	0.0604	0.0603
Schistosoma mansoni	hypothetical protein	0.0115	0.014	0.0139
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0512	0.0776	0.0775
Brugia malayi	Niemann-Pick C1 protein precursor	0.03	0.0436	0.0435
Schistosoma mansoni	amine oxidase	0.0164	0.0218	0.0217
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0918	0.1425	0.1421
Loa Loa (eye worm)	DR-78	0.0242	0.0343	0.0343
Trichomonas vaginalis	conserved hypothetical protein	0.0782	0.1208	0.1204
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0028	0.0024
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0061	0.0053	0.0052
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0016	0.0042
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0405	0.0604	0.0603
Brugia malayi	hypothetical protein	0.0041	0.0022	0.0021
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0271	0.0389	0.0389
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.005	0.0049
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.6277	1	1
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0061	0.0053	0.0052
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0181	0.0246	0.0245
Brugia malayi	Serotonin receptor	0.049	0.0739	0.0739
Schistosoma mansoni	hypothetical protein	0.0041	0.0022	0.0021
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	glutaminase 2	0.028	0.0405	0.0405
Plasmodium vivax	multidomain scavenger receptor, putative	0.0041	0.0022	0.0328
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0002	0.0001
Brugia malayi	Nuclear hormone receptor-like 1	0.0271	0.0389	0.0388
Brugia malayi	follicle stimulating hormone receptor	0.026	0.0372	0.0371
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Schistosoma mansoni	metastasis-associated protein 1 (mta1)	0.0031	0.0006	0.0005
Brugia malayi	amine oxidase, flavin-containing family protein	0.0181	0.0245	0.0244
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0477	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0208	0.0208
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0129	0.0162	0.0162
Entamoeba histolytica	hypothetical protein	0.1187	0.1856	0.1852
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0072	0.0072	0.0241
Loa Loa (eye worm)	MH2 domain-containing protein	0.0243	0.0345	0.0345
Onchocerca volvulus		0.0037	0.0016	0.0088
Trichomonas vaginalis	fk506-binding protein, putative	0.0061	0.0053	0.0049
Echinococcus granulosus	expressed conserved protein	0.0282	0.0407	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0006	0.0006
Onchocerca volvulus	Bile acid receptor homolog	0.0512	0.0776	0.4552
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.005	0.0036	0.0036
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0405	0.0604	0.0603
Schistosoma mansoni	nuclear receptor	0.0242	0.0343	0.0342
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.0042	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.1856	0.1852
Schistosoma mansoni	topbp1	0.003	0.0004	0.0003
Schistosoma mansoni	DNA ligase IV	0.003	0.0004	0.0003
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0918	0.1425	0.1424
Mycobacterium ulcerans	lipase LipD	0.0037	0.0016	0.0042
Echinococcus granulosus	Niemann Pick C1 protein	0.03	0.0436	0.0435
Loa Loa (eye worm)	phosphatidylinositol 3	0.6277	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0477	0.0719	0.0718
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0405	0.0604	0.06
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0405	0.0604	0.0603
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0119	0.0146	0.0145
Schistosoma mansoni	loxhd1	0.0041	0.0022	0.0021
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0512	0.0776	0.0775
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0512	0.0776	0.4552
Entamoeba histolytica	hypothetical protein	0.0405	0.0604	0.06
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3713	0.5898	0.5896
Schistosoma mansoni	sodium/chloride dependent transporter	0.0081	0.0085	0.0085
Brugia malayi	hypothetical protein	0.0081	0.0085	0.0085
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0405	0.0604	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0548	0.0833	0.0833
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0016	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0389	0.0389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3751	0.5958	0.5956
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0016	0.0022
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1187	0.1856	0.1852
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.03	0.0436	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0389	0.0389
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0405	0.0604	0.0603
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0405	0.0604	0.06
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0164	0.0218	0.0217
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.0042	0.0672
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0405	0.0604	0.06
Schistosoma mansoni	immunophilin	0.0052	0.004	0.0039
Schistosoma mansoni	rest corepressor (corest) protein	0.0031	0.0006	0.0005
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.003	0.0004	0.00000022677
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0512	0.0776	0.0775
Echinococcus multilocularis	ecdysone induced protein 78C	0.0512	0.0776	0.0775
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0358	0.0358
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0405	0.0604	0.0603
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0119	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0203	0.0203
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0061	0.0053	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1684	0.2651	0.2648
Brugia malayi	hypothetical protein	0.0242	0.0343	0.0342
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0405	0.0604	0.06
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0017	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2105	0.3324	0.3322
Schistosoma mansoni	sodium/chloride dependent transporter	0.0081	0.0086	0.0085
Schistosoma mansoni	hypothetical protein	0.0079	0.0083	0.0082
Brugia malayi	beta-lactamase	0.0037	0.0016	0.0015
Brugia malayi	hypothetical protein	0.0271	0.0389	0.0388
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.6277	1	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0081	0.0085	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.1323	0.2073	0.207
Echinococcus granulosus	metastasis associated protein MTA1	0.0031	0.0006	0.0005
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2105	0.3324	0.3323
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1187	0.1856	0.1852
Entamoeba histolytica	hypothetical protein	0.0036	0.0014	0.001
Entamoeba histolytica	hypothetical protein	0.0036	0.0014	0.001
Brugia malayi	nuclear hormone receptor	0.0512	0.0776	0.0775
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0405	0.0604	0.0603
Echinococcus granulosus	mesoderm induction early response protein 1	0.0031	0.0006	0.0005
Onchocerca volvulus		0.0037	0.0016	0.0088
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0251	0.0358	0.0357
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0405	0.0604	0.06
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0016	0.0014
Leishmania major	hypothetical protein, conserved	0.0405	0.0604	0.0589
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.0218	0.0818
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0405	0.0604	0.06
Schistosoma mansoni	hypothetical protein	0.0918	0.1425	0.1424
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.1642	0.2584	0.2583
Echinococcus granulosus	sterol regulatory element binding protein	0.0129	0.0162	0.0161
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0405	0.0604	0.06
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0072	0.0242
Brugia malayi	hypothetical protein	0.0548	0.0833	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0502	0.0502
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.005	0.0049
Brugia malayi	MH2 domain containing protein	0.0243	0.0345	0.0344
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0041	0.0021	0.002
Schistosoma mansoni	microtubule-associated protein tau	0.1395	0.2188	0.2187
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0405	0.0604	0.06
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0271	0.0389	0.0388
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0405	0.0604	0.2341
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0242	0.0343	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Brugia malayi	hypothetical protein	0.0164	0.0218	0.0217
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0111	0.0133	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5359	0.8531	0.8531
Schistosoma mansoni	patched 1	0.0129	0.0162	0.0161
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0072	0.0072	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.0022	0.0021
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Echinococcus multilocularis	expressed conserved protein	0.0282	0.0407	0.0406
Onchocerca volvulus	Huntingtin homolog	0.0127	0.016	0.0934
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0017	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0512	0.0776	0.0775
Plasmodium vivax	hypothetical protein	0.0031	0.0006	0.0061
Echinococcus granulosus	hypothetical protein	0.0726	0.1118	0.1117
Brugia malayi	Doublecortin family protein	0.0041	0.0022	0.0021
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0512	0.0776	0.0775
Leishmania major	fk506-binding protein 1-like protein	0.0061	0.0053	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0002	0.0002
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.0022	0.0021
Echinococcus granulosus	microtubule associated protein 2	0.1395	0.2188	0.2187
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.005	0.0165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3713	0.5898	0.5896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Loa Loa (eye worm)	hypothetical protein	0.1061	0.1654	0.1654
Onchocerca volvulus		0.0037	0.0016	0.0088
Schistosoma mansoni	chromosome transmission fidelity factor	0.003	0.0004	0.0003
Onchocerca volvulus		0.0477	0.0719	0.4219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4993	0.7945	0.7944
Brugia malayi	Nuclear hormone receptor-like 1	0.0512	0.0776	0.0775
Brugia malayi	nuclear receptor RXR	0.0271	0.0389	0.0388
Echinococcus granulosus	nuclear receptor nhr 48	0.0242	0.0343	0.0342
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0405	0.0604	0.06
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0016	0.0022
Entamoeba histolytica	protein kinase, putative	0.0066	0.0061	0.0057
Treponema pallidum	fructose-bisphosphate aldolase	0.0291	0.0421	0.5839
Loa Loa (eye worm)	hypothetical protein	0.0477	0.0719	0.0719
Echinococcus multilocularis	tumor protein p63	0.0342	0.0503	0.0502
Entamoeba histolytica	hypothetical protein	0.0405	0.0604	0.06
Entamoeba histolytica	protein kinase, putative	0.0066	0.0061	0.0057
Schistosoma mansoni	amine oxidase	0.0164	0.0218	0.0217
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.0022	0.0021
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0017	0.0013
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0113
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0242	0.0343	0.0342
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0405	0.0604	0.0603
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0017	0.0013
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0061	0.0053	0.0052
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0242	0.0343	0.2008
Echinococcus multilocularis	sterol regulatory element binding protein	0.0129	0.0162	0.0161
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.0022	0.0021
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0016	0.0022
Brugia malayi	latrophilin 2 splice variant baaae	0.0172	0.0231	0.023
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.6277	1	1
Onchocerca volvulus		0.0512	0.0776	0.4552
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0405	0.0604	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0085
Brugia malayi	glutaminase DH11.1	0.028	0.0405	0.0404
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0305	0.0443	0.0443
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2968	0.4706	0.4705
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0016	0.0042
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0405	0.0604	0.0602
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0512	0.0776	0.0776
Echinococcus multilocularis	rac serine:threonine kinase	0.0045	0.0028	0.0027
Brugia malayi	nuclear hormone receptor family member odr-7	0.0242	0.0343	0.0342
Brugia malayi	hypothetical protein	0.003	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0218	0.0218
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.005	0.0165
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0016	0.0015
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0001	0.0001
Brugia malayi	Pax transcription activation domain interacting protein	0.003	0.0004	0.0003
Onchocerca volvulus	CoRest homolog	0.1092	0.1703	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6277	1	1
Echinococcus granulosus	GPCR family 2	0.0079	0.0083	0.0082
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2105	0.3324	0.3324
Schistosoma mansoni	coup transcription factor	0.0512	0.0776	0.0775
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0271	0.0389	0.0388
Echinococcus granulosus	snurportin 1	0.0306	0.0446	0.0445
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0072	0.1127
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0052	0.004	0.004
Plasmodium vivax	hypothetical protein, conserved	0.0164	0.0218	0.3585
Toxoplasma gondii	hypothetical protein	0.0081	0.0085	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4075	0.6476	0.6475
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.005	0.0049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3384	0.5371	0.5369
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0324	0.0474	0.0474
Plasmodium vivax	amine transporter, putative	0.0081	0.0085	0.1389
Brugia malayi	ELM2 domain containing protein	0.0031	0.0006	0.0005
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0038	0.0108
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0164	0.0218	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0016	0.0012
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2607	0.4128	0.4127
Loa Loa (eye worm)	steroid hormone receptor	0.0512	0.0776	0.0776
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.0042	0.0672
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Loa Loa (eye worm)	hypothetical protein	0.1323	0.2073	0.2073
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0119	0.0146	0.0145
Loa Loa (eye worm)	hypothetical protein	0.1092	0.1703	0.1703
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0164	0.0218	0.3585
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0016	0.0016
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0016	0.0022
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.003	0.0004	0.00000022677
Plasmodium vivax	replication factor C subunit 1, putative	0.003	0.0004	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0405	0.0604	0.0603
Schistosoma mansoni	nuclear hormone receptor	0.0242	0.0343	0.0342
Brugia malayi	hypothetical protein	0.0155	0.0203	0.0203
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0389	0.0389
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0405	0.0604	0.06
Onchocerca volvulus		0.0041	0.0022	0.0122
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0017	0.0013
Schistosoma mansoni	hypothetical protein	0.0405	0.0604	0.0603
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0251	0.0358	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0127	0.016	0.016
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0405	0.0604	0.0603
Schistosoma mansoni	hypothetical protein	0.0172	0.0231	0.023
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0181	0.0246	0.0245
Trichomonas vaginalis	esterase, putative	0.0037	0.0016	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0218	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0129	0.0162	0.0158
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.6277	1	1
Echinococcus multilocularis	rest corepressor (corest) protein	0.0031	0.0006	0.0005
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0061	0.0053	0.0051
Schistosoma mansoni	nuclear receptor	0.0242	0.0343	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Onchocerca volvulus	Huntingtin homolog	0.0127	0.016	0.0934
Brugia malayi	Protein kinase domain containing protein	0.0066	0.0061	0.0061
Brugia malayi	DKFZp564C0469 protein	0.003	0.0004	0.0003
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.003	0.0004	0.0003
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.0042	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0405	0.0604	0.0811
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Loa Loa (eye worm)	hypothetical protein	0.1187	0.1856	0.1856
Echinococcus multilocularis	serine protein kinase ATM	0.1187	0.1856	0.1855
Echinococcus multilocularis		0.0405	0.0604	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0042	0.0042
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0081	0.0085	0.0085
Echinococcus multilocularis	serotonin transporter	0.0477	0.0719	0.0718
Schistosoma mansoni	retinoic acid receptor RXR	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0011	0.0011
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.004	0.0039
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0405	0.0604	0.06
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0085
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.0589
Echinococcus multilocularis	neuropeptide receptor A26	0.0489	0.0738	0.0737
Schistosoma mansoni	thyroid hormone receptor	0.0512	0.0776	0.0775
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.0011	0.001
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4998	0.7953	0.795
Schistosoma mansoni	hypothetical protein	0.0124	0.0155	0.0154
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0061	0.0053	0.0847
Echinococcus granulosus	nervana 2	0.0041	0.0021	0.002
Schistosoma mansoni	serine/threonine-protein kinase	0.0045	0.0028	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Loa Loa (eye worm)	phosphatidylinositol 3	0.0405	0.0604	0.0604
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0405	0.0604	0.0603
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0079	0.0083	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2105	0.3324	0.3322
Schistosoma mansoni	lipoxygenase	0.0107	0.0128	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0014	0.0013
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0512	0.0776	0.0775
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0242	0.0343	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0042	0.0042
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0263	0.0263
Echinococcus multilocularis	protein dispatched 1	0.0147	0.0191	0.019
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2105	0.3324	0.3314
Echinococcus multilocularis	Polycystic kidney disease protein	0.0041	0.0022	0.0021
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0081	0.0085	0.0085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4993	0.7945	0.7944
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0061	0.0053	0.0053
Echinococcus granulosus	Protein patched homolog 1	0.0129	0.0162	0.0161
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0081	0.0085	0.0085
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0111	0.0133	0.0129
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2105	0.3324	0.3324
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2105	0.3324	0.3322
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0072	0.0056
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0017	0.0045
Mycobacterium ulcerans	oxidoreductase	0.0164	0.0218	0.0762
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0016	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0127	0.016	0.016
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.4132	0.6568	0.6568
Echinococcus granulosus	metastasis associated protein 1 mta1	0.0031	0.0006	0.0005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0512	0.0776	0.0775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2105	0.3324	0.3322
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0162	0.0162
Leishmania major	peptidylprolyl isomerase-like protein	0.0061	0.0053	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2105	0.3324	0.3322
Leishmania major	UDP-galactopyranose mutase	0.0164	0.0218	0.0202
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0017	0.0016
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0604	0.0604
Entamoeba histolytica	hypothetical protein	0.0036	0.0014	0.001
Schistosoma mansoni	hypothetical protein	0.0079	0.0083	0.0082
Echinococcus granulosus	Glutaredoxin protein 5	0.0041	0.0021	0.002
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Giardia lamblia	GTOR	0.6277	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0014	0.0013
Giardia lamblia	Kinase, AGC PKA	0.0041	0.0022	0.0018
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0079	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0389	0.0389
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0016	0.0022
Echinococcus multilocularis	replication factor c subunit 1	0.003	0.0004	0.0003
Brugia malayi	ecdysone receptor	0.0242	0.0343	0.0342
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0072	0.0071
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3384	0.5371	0.5369
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0016	0.0022
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0061	0.0053	0.0051
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0405	0.0604	0.0603
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0016	0.0198
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1323	0.2073	0.2789
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0512	0.0776	0.0775
Schistosoma mansoni	topbp1	0.003	0.0004	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0512	0.0776	0.0775
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0512	0.0776	0.0775
Brugia malayi	Steroid receptor seven-up type 2	0.0512	0.0776	0.0775
Loa Loa (eye worm)	phosphatidylinositol 3	0.0405	0.0604	0.0604
Echinococcus granulosus	neuropeptide receptor A26	0.0489	0.0738	0.0737
Echinococcus granulosus	serine protein kinase ATM	0.1187	0.1856	0.1855
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0017	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3389	0.5379	0.5378
Loa Loa (eye worm)	hypothetical protein	0.1279	0.2003	0.2003
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0405	0.0604	0.0603
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0512	0.0776	0.0775
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0405	0.0604	0.0604
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0079	0.0083	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1187	0.1856	0.1855
Loa Loa (eye worm)	hypothetical protein	0.03	0.0436	0.0436
Onchocerca volvulus		0.0341	0.0502	0.2943
Entamoeba histolytica	protein kinase, putative	0.0062	0.0055	0.0051
Echinococcus granulosus	nervana 2	0.0041	0.0021	0.002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0512	0.0776	0.0776
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0016	0.0016
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0405	0.0604	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0022	0.0022
Onchocerca volvulus		0.0405	0.0604	0.3543
Brugia malayi	photoreceptor-specific nuclear receptor	0.0512	0.0776	0.0775
Brugia malayi	nuclear receptor NHR-67	0.0242	0.0343	0.0342
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0164	0.0218	0.3585
Echinococcus granulosus	FTZ F1 alpha	0.0512	0.0776	0.0775
Schistosoma mansoni	hypothetical protein	0.0079	0.0083	0.0082
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0044	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4993	0.7945	0.7944
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0016	0.0022
Echinococcus granulosus	thyroid hormone receptor alpha	0.0242	0.0343	0.0342
Trypanosoma cruzi	Protein kinase B	0.0045	0.0028	0.0024
Echinococcus multilocularis	geminin	0.0514	0.0778	0.0778
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0242	0.0343	0.0342
Brugia malayi	Importin beta-1 subunit	0.0029	0.0002	0.0001
Entamoeba histolytica	protein kinase rad3, putative	0.1187	0.1856	0.1852
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0271	0.0389	0.0388
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0242	0.0343	0.2008
Plasmodium falciparum	replication factor C subunit 1, putative	0.003	0.0004	0.0034
Echinococcus multilocularis	voltage gated potassium channel	0.0034	0.0011	0.001
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0083	0.0083
Schistosoma mansoni	hypothetical protein	0.0306	0.0446	0.0445
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0072	0.0241
Onchocerca volvulus		0.0081	0.0085	0.0497
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0405	0.0604	1
Toxoplasma gondii	hypothetical protein	0.0081	0.0085	0.0113
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.06
Echinococcus multilocularis	nervana 2	0.0041	0.0021	0.002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0113
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0041	0.0021	0.002
Brugia malayi	ecdysteroid receptor	0.0512	0.0776	0.0775
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0061	0.0053	0.0049
Brugia malayi	Nuclear hormone receptor E75	0.0242	0.0343	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0085
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0164	0.0218	0.3585
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0022	0.0022
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0041	0.0022	0.0021
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Loa Loa (eye worm)	serotonin transporter b	0.0477	0.0719	0.0719
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0512	0.0776	0.0775
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0081	0.0085	0.0085
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0001	0.0001
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0164	0.0218	0.3562
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0142	0.0183	0.299
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0512	0.0776	0.0775
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0512	0.0776	0.0775
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.026	0.0372	0.0372
Echinococcus multilocularis		0.0164	0.0218	0.0217
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0072	0.0072	0.0241
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Echinococcus granulosus	ecdysone induced protein 78C	0.0512	0.0776	0.0775
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0164	0.0218	0.0214
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.0602
Loa Loa (eye worm)	norepinephrine transporter	0.0477	0.0719	0.0719
Brugia malayi	ELM2 domain containing protein	0.0031	0.0006	0.0005
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0405	0.0604	0.06
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0405	0.0604	0.06
Echinococcus granulosus	serotonin transporter	0.0477	0.0719	0.0718
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0242	0.0343	0.0342
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0042	0.0042
Schistosoma mansoni	serine/threonine-protein kinase	0.0045	0.0028	0.0027
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0038	0.0108
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0405	0.0604	0.06
Onchocerca volvulus		0.0242	0.0343	0.2008
Entamoeba histolytica	hypothetical protein	0.0036	0.0014	0.001
Brugia malayi	Latrophilin receptor protein 2	0.0079	0.0083	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1783	0.2809	1
Echinococcus multilocularis	protein patched	0.0129	0.0162	0.0161
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0016	0.0022
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0405	0.0604	0.06
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0405	0.0604	0.0603
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1783	0.2809	1
Toxoplasma gondii	FATC domain-containing protein	0.1187	0.1856	0.2497
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0081	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0782	0.1208	0.1208
Schistosoma mansoni	hypothetical protein	0.0124	0.0155	0.0154
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0036	0.0035
Echinococcus multilocularis	microtubule associated protein 2	0.1395	0.2188	0.2187
Echinococcus granulosus	sodium and chloride dependent glycine	0.0081	0.0085	0.0085
Schistosoma mansoni	sterol O-acyltransferase 1	0.0213	0.0297	0.0296
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0061	0.0053	0.0049
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.6277	1	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0041	0.0022	0.0021
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0242	0.0343	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0036	0.0014	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.421	0.6693	0.6692
Schistosoma mansoni	sodium/chloride dependent transporter	0.0477	0.0719	0.0718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4669	0.7426	0.7425
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0405	0.0604	0.0603
Schistosoma mansoni	immunophilin	0.0061	0.0053	0.0052
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0164	0.0218	0.0217
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0782	0.1208	0.1204
Schistosoma mansoni	RAR-like nuclear receptor	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0477	0.0719	0.0719
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0405	0.0604	0.06
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0405	0.0604	0.0811
Brugia malayi	nuclear receptor NHR-88	0.0242	0.0343	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Brugia malayi	hypothetical protein	0.0041	0.0022	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3389	0.5379	0.5378
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4669	0.7426	1
Schistosoma mansoni	hypothetical protein	0.0124	0.0155	0.0154
Echinococcus granulosus	Niemann Pick C1 protein	0.0429	0.0642	0.0641
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3389	0.5379	0.5378
Brugia malayi	FAT domain containing protein	0.0918	0.1425	0.1424
Onchocerca volvulus		0.003	0.0004	0.0018
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1187	0.1856	0.1855
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0041	0.0022	0.0329
Loa Loa (eye worm)	transcription factor SMAD2	0.0243	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0031	0.0006	0.0005
Plasmodium vivax	hypothetical protein, conserved	0.0405	0.0604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0782	0.1208	0.1204
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0017	0.0013
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0061	0.0053	0.0052
Onchocerca volvulus		0.0081	0.0085	0.0497
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0405	0.0604	0.0811
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0072	0.0072	0.0241
Schistosoma mansoni	glutaminase	0.028	0.0405	0.0404
Brugia malayi	beta-lactamase family protein	0.0037	0.0016	0.0015
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0016	0.0022
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2105	0.3324	0.3323
Echinococcus granulosus	serine/threonine protein kinase	0.0045	0.0028	0.0027
Brugia malayi	Inositol-1	0.0038	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1187	0.1856	0.1855
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0405	0.0604	0.06
Echinococcus granulosus	replication factor c subunit 1	0.003	0.0004	0.0003
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0164	0.0218	0.0214
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0016	0.0015
Loa Loa (eye worm)	FKBP5 protein	0.0061	0.0053	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0405	0.0604	0.06
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0512	0.0776	0.0775
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0061	0.0053	0.0049
Schistosoma mansoni	voltage-gated potassium channel	0.013	0.0163	0.0162
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0079	0.0083	0.0082
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0028	0.0024
Echinococcus granulosus	tumor protein p63	0.0342	0.0503	0.0502
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.003	0.0004	0.00000022677
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.005	0.0049
Brugia malayi	RNA, U transporter 1	0.0082	0.0087	0.0086
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1187	0.1856	0.1855
Brugia malayi	beta-lactamase family protein	0.0037	0.0016	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0242	0.0343	0.0342
Toxoplasma gondii	AGC kinase	0.0062	0.0055	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0085	0.0085
Brugia malayi	Nuclear hormone receptor-like 1	0.0271	0.0389	0.0388
Loa Loa (eye worm)	phosphatidylinositol 3	0.2105	0.3324	0.3324
Leishmania major	phosphatidylinositol kinase, putative	0.0405	0.0604	0.0589
Schistosoma mansoni	zinc finger protein	0.0242	0.0343	0.0342
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.005	0.0157
Onchocerca volvulus		0.0081	0.0085	0.0497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3751	0.5958	0.5956
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0324	0.0474	0.0474
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0016	0.0022
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.001	0.0104
Echinococcus multilocularis	zinc finger protein 541	0.0031	0.0006	0.0005
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1187	0.1856	0.1855
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.06
Echinococcus multilocularis	Niemann Pick C1 protein	0.0429	0.0642	0.0641
Trichomonas vaginalis	immunophilin, putative	0.0061	0.0053	0.0049
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0242	0.0343	0.0343
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0034	0.0011	0.001
Loa Loa (eye worm)	hypothetical protein	0.0213	0.0297	0.0297
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0142	0.0183	0.0683
Mycobacterium ulcerans	glutaminase	0.028	0.0405	0.1428
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0041	0.0022	0.0329
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0016	0.0012
Schistosoma mansoni	nuclear hormone receptor	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Onchocerca volvulus		0.0242	0.0343	0.2008
Echinococcus multilocularis	metastasis associated protein MTA1	0.0031	0.0006	0.0005
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.6277	1	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0061	0.0053	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0512	0.0776	0.0776
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2105	0.3324	0.3322
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0062	0.0055	0.0055
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0061	0.0053	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0512	0.0776	0.0775
Brugia malayi	nuclear receptor NHR-88	0.0512	0.0776	0.0775
Loa Loa (eye worm)	doublecortin family protein	0.0041	0.0022	0.0022
Onchocerca volvulus		0.005	0.0036	0.0207
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0017	0.0016
Schistosoma mansoni	nuclear receptor nhr-48	0.0242	0.0343	0.0342
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0081	0.0085	0.0085
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0041	0.0022	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0072	0.0072
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0014	0.0013
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0405	0.0604	0.0589
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0061	0.0053	0.0049
Echinococcus multilocularis	nuclear receptor nhr 48	0.0242	0.0343	0.0342
Echinococcus granulosus	SANT DNA binding	0.0031	0.0006	0.0005
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0072	0.0068
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0061	0.0053	0.0049
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0038	0.0108
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Plasmodium vivax	hypothetical protein, conserved	0.0081	0.0085	0.1389
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1187	0.1856	0.1855
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0242	0.0343	0.0342
Toxoplasma gondii	ABC1 family protein	0.0037	0.0016	0.0019
Echinococcus granulosus	serine threonine protein kinase nrc	0.0041	0.0022	0.0021
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0016	0.0042
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0052	0.004	0.0039
Loa Loa (eye worm)	nuclear hormone receptor	0.0242	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0405	0.0604	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0918	0.1425	0.1425
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0164	0.0218	0.0217
Echinococcus multilocularis	SANT, DNA binding	0.0031	0.0006	0.0005
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0061	0.0053	0.0049
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	hypothetical protein	0.0512	0.0776	0.0776
Echinococcus granulosus	zinc finger protein 541	0.0031	0.0006	0.0005
Mycobacterium ulcerans	dehydrogenase	0.0164	0.0218	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0324	0.0474	0.0474
Schistosoma mansoni	rest corepressor (corest) protein	0.0031	0.0006	0.0005
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0081	0.0085	0.3814
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0072	0.0241
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2105	0.3324	0.3314
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0512	0.0776	0.0775
Brugia malayi	Nuclear hormone receptor E75	0.0242	0.0343	0.0342
Echinococcus granulosus	neuropeptide s receptor	0.0489	0.0738	0.0737
Echinococcus multilocularis	nervana 2	0.0041	0.0021	0.002
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1187	0.1856	0.1854
Echinococcus multilocularis	neuropeptide s receptor	0.0489	0.0738	0.0737
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0079	0.0083	0.0082
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0081	0.0085	0.0085
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0405	0.0604	0.0589
Brugia malayi	Myb-like DNA-binding domain containing protein	0.1061	0.1654	0.1653
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.003	0.0004	0.0003
Entamoeba histolytica	protein kinase 2, putative	0.0041	0.0022	0.0018
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0072	0.0071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0512	0.0776	0.0776
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0512	0.0776	0.0775
Brugia malayi	CHE-14 protein	0.0129	0.0162	0.0161
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0016	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2105	0.3324	0.3322
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0242	0.0343	0.0342
Echinococcus granulosus	sodium and chloride dependent glycine	0.0081	0.0085	0.0085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6277	1	1
Leishmania major	hypothetical protein, unknown function	0.0405	0.0604	0.0589
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.0602
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0061	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0512	0.0776	0.0775
Brugia malayi	tailless protein	0.0242	0.0343	0.0342
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0324	0.0474	0.0474
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0045	0.0028	0.0024
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0405	0.0604	0.06
Loa Loa (eye worm)	phosphatidylinositol 3	0.0405	0.0604	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0405	0.0604	1
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0164	0.0218	0.0762
Plasmodium vivax	hypothetical protein	0.0405	0.0604	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0405	0.0604	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Brugia malayi	SWIRM domain containing protein	0.0341	0.0502	0.0501
Echinococcus multilocularis	FTZ F1 alpha	0.0512	0.0776	0.0775
Schistosoma mansoni	polycystin 1-related	0.0041	0.0022	0.0021
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0142	0.0183	0.064
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0512	0.0776	0.0775
Brugia malayi	hypothetical protein	0.0271	0.0389	0.0388
Plasmodium falciparum	LCCL domain-containing protein	0.0041	0.0022	0.0328
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	0.06
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0405	0.0604	1
Schistosoma mansoni	hypothetical protein	0.0124	0.0155	0.0154
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0512	0.0776	0.0775
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0512	0.0776	0.0775
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.6277	1	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0081	0.0085	0.0085
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1187	0.1856	0.1852
Onchocerca volvulus	Protein ultraspiracle homolog	0.0512	0.0776	0.4552
Plasmodium vivax	hypothetical protein, conserved	0.0164	0.0218	0.3585
Giardia lamblia	Fructose-bisphosphate aldolase	0.0291	0.0421	0.0418
Brugia malayi	orphan nuclear receptor NR2E1	0.0242	0.0343	0.0342
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.005	0.0034
Onchocerca volvulus		0.0072	0.0072	0.0415
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0081	0.0085	0.0085
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0405	0.0604	0.06
Echinococcus granulosus	REST corepressor 3	0.0031	0.0006	0.0005
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4998	0.7953	0.7953
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.6277	1	1
Brugia malayi	hypothetical protein	0.0036	0.0014	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0072	0.0241
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0081	0.0085	0.0085
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0016	0.0015
Schistosoma mansoni	voltage-gated potassium channel	0.013	0.0163	0.0162
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0041	0.0022	0.0018
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0512	0.0776	0.0775
Brugia malayi	hypothetical protein	0.003	0.0004	0.0003
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0291	0.0421	0.0418
Schistosoma mansoni	hypothetical protein	0.0514	0.0778	0.0778
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0512	0.0776	0.0776
Echinococcus multilocularis	RUN	0.0041	0.0022	0.0021
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0512	0.0776	0.0775
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0405	0.0604	0.0603
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0242	0.0343	0.0342
Brugia malayi	topoisomerase	0.003	0.0004	0.0003
Mycobacterium ulcerans	hydrolase/amidase	0.0287	0.0415	0.1466
Loa Loa (eye worm)	hypothetical protein	0.0477	0.0719	0.0719
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0017	0.0013
Schistosoma mansoni	importin beta-1	0.0029	0.0002	0.0001
Trypanosoma cruzi	target of rapamycin kinase 3	0.4998	0.7953	0.7952
Entamoeba histolytica	hypothetical protein	0.0405	0.0604	0.06
Brugia malayi	p70 ribosomal S6 kinase beta	0.0062	0.0055	0.0054
Brugia malayi	conserved hypotetical protein	0.0242	0.0343	0.0342
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1187	0.1856	0.1852
Echinococcus multilocularis	Niemann Pick C1 protein	0.03	0.0436	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0343	0.0343
Plasmodium falciparum	transporter, putative	0.0081	0.0085	0.1389
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0034	0.0011	0.001

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.06 uM	Capability to inhibit the binding of [3H]-LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL.	1324316
IC50 (binding)	= 0.06 uM	Capability to inhibit the binding of [3H]-LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M	ChEMBL.	1324316

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

Search by CAS
PubChem: 132425

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 178317