Detailed information for compound 1796159

Basic information

Technical information
  • TDR Targets ID: 1796159
  • Name: 2-(bromomethyl)-1,3-dimethoxyanthracene-9,10- dione
  • MW: 361.187 | Formula: C17H13BrO4
  • H donors: 0 H acceptors: 2 LogP: 3.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCc1c(OC)cc2c(c1OC)C(=O)c1c(C2=O)cccc1
  • InChi: 1S/C17H13BrO4/c1-21-13-7-11-14(17(22-2)12(13)8-18)16(20)10-6-4-3-5-9(10)15(11)19/h3-7H,8H2,1-2H3
  • InChiKey: PXNKUQYPPWDMFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(bromomethyl)-1,3-dimethoxy-anthracene-9,10-dione
  • 2-(bromomethyl)-1,3-dimethoxy-9,10-anthraquinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.3844
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0152 0.2843 0.282
Schistosoma mansoni cell adhesion molecule 0.0066 0.0867 0.1052
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Brugia malayi Immunoglobulin I-set domain containing protein 0.0188 0.3666 0.3646
Loa Loa (eye worm) TK/EGFR protein kinase 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0036 0.0189 0.0157
Schistosoma mansoni titin 0.0123 0.2165 0.2688
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.6085 1
Echinococcus multilocularis FL cytokine receptor 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0159 0.2996 0.2973
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.2661 0.2637
Schistosoma mansoni titin 0.0029 0.0037 0.0006
Echinococcus multilocularis roundabout 2 0.03 0.6213 0.62
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1525 0.9643
Mycobacterium tuberculosis Conserved protein 0.0071 0.0994 0.1018
Echinococcus granulosus insulin growth factor binding 0.0029 0.0037 0.0005
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Loa Loa (eye worm) hypothetical protein 0.0031 0.0066 0.0034
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0036 0.0196 0.0165
Echinococcus granulosus tyrosine protein kinase Src64B 0.0036 0.0189 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0029 0.0037 0.0005
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0189 0.0157
Plasmodium vivax glutathione reductase, putative 0.0046 0.0421 0.3767
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0994 0.0821
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0123 0.2165 0.214
Brugia malayi hypothetical protein 0.0036 0.0189 0.0157
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0112 0.1913 0.237
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus survival motor neuron protein 1 0.0466 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.9765 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0036 0.0189 0.0157
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) hypothetical protein 0.005 0.0508 0.0477
Schistosoma mansoni protein kinase 0.0036 0.0196 0.0207
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0421 0.3767
Loa Loa (eye worm) hypothetical protein 0.0234 0.4712 0.4695
Brugia malayi SRC-1 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) glutathione reductase 0.0046 0.0421 0.039
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0036 0.0189 0.1203
Echinococcus multilocularis roundabout 2 0.0188 0.3666 0.3646
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2546 0.4184
Mycobacterium leprae Probable lipase LipE 0.0071 0.0994 0.3146
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus granulosus protein tyrosine kinase 0.0036 0.0189 0.0157
Echinococcus granulosus kinase suppressor of Ras 1 0.0036 0.0189 0.0157
Echinococcus multilocularis roundabout 2 0.0188 0.3666 0.3646
Echinococcus granulosus lachesin 0.0066 0.0867 0.0837
Mycobacterium ulcerans branched-chain amino acid aminotransferase 0.0097 0.1574 0.5418
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0029 0.0037 0.0005
Echinococcus multilocularis kinase suppressor of Ras 1 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0234 0.4712 0.4695
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Leishmania major protein kinase, putative 0.0036 0.0196 0.0323
Loa Loa (eye worm) TK/Met protein kinase 0.0036 0.0189 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0421 0.0691
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0036 0.0189 0.0157
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Schistosoma mansoni basigin related 0.0036 0.0196 0.0207
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0112 0.1913 0.237
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus tyrosine kinase 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0123 0.2165 0.2141
Loa Loa (eye worm) TK/FAK protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0066 0.0867 0.0837
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0036 0.0196 0.0165
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0514 0.0526
Echinococcus multilocularis titin 0.0152 0.2843 0.282
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0189 0.0157
Giardia lamblia Protein 21.1 0.0036 0.0189 0.1203
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Plasmodium falciparum tyrosine kinase-like protein 0.0036 0.0189 0.1695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0377 0.7967 1
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Brugia malayi Protein-tyrosine phosphatase 0.0123 0.2165 0.214
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0036 0.0196 0.1247
Giardia lamblia Kinase, PLK 0.0095 0.1525 0.9686
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0159 0.2989 0.2966
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.6085 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Plasmodium vivax tyrosine kinase-like protein, putative 0.0036 0.0189 0.1695
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0036 0.0189 0.0157
Echinococcus granulosus fibroblast growth factor receptor 4 0.0036 0.0189 0.0157
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0706 0.0675
Echinococcus multilocularis protein KINase family member (kin 25) 0.0036 0.0189 0.0157
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0173 0.0177
Echinococcus multilocularis heat shock protein 70 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus granulosus Netrin receptor DCC 0.0123 0.2165 0.214
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Onchocerca volvulus Putative titin 0.0029 0.0037 0.0005
Echinococcus multilocularis Immunoglobulin 0.0112 0.1913 0.1886
Schistosoma mansoni vesicular amine transporter 0.0112 0.1913 0.237
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis titin 0.0029 0.0037 0.0005
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis neuroglian 0.0141 0.2583 0.2559
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0994 0.0821
Trypanosoma brucei Flagellum attachment zone protein 20 0.0036 0.0189 0.0311
Echinococcus multilocularis anosmin 1 0.0123 0.2165 0.214
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0189 0.000000057217
Plasmodium vivax protein kinase, putative 0.0036 0.0189 0.1695
Toxoplasma gondii ABC1 family protein 0.0071 0.0994 0.6314
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0196 0.0323
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0036 0.0196 0.0165
Echinococcus granulosus tyrosine protein kinase pr2 0.0036 0.0189 0.0157
Schistosoma mansoni cell adhesion molecule 0.0152 0.2836 0.3534
Echinococcus granulosus EG95 0.0123 0.2165 0.214
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Schistosoma mansoni titin 0.0152 0.2843 0.3543
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0189 0.0157
Brugia malayi jmjC domain containing protein 0.0096 0.1548 0.1521
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0036 0.0189 0.1203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0377 0.7967 0.796
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0994 0.0965
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1525 0.1497
Schistosoma mansoni septate junction protein 0.0036 0.0196 0.0207
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0994 0.3421
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Echinococcus granulosus tyrosine protein kinase shark 0.0036 0.0189 0.0157
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2905 0.2975
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.1117 0.1088
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Echinococcus granulosus roundabout 2 0.03 0.6213 0.62
Brugia malayi SH2 domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis transfer RNA-Phe 0.0152 0.2836 0.2813
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0188 0.3666 0.3646
Brugia malayi Tyrosine-protein kinase abl-1 0.0036 0.0189 0.0157
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.2207 0.2182
Loa Loa (eye worm) UNCoordinated family member 0.0123 0.2165 0.214
Echinococcus granulosus peroxidasin 0.0066 0.0867 0.0837
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Echinococcus multilocularis titin 0.0029 0.0037 0.0005
Schistosoma mansoni hypothetical protein 0.0124 0.2207 0.2741
Trichomonas vaginalis branched-chain amino acid aminotransferase, putative 0.0097 0.1574 0.1412
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0189 0.0157
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1117 0.7096
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0196 0.0165
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0123 0.2165 0.214
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0421 0.0431
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Onchocerca volvulus 0.0029 0.0037 0.0005
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0036 0.0196 0.0165
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Loa Loa (eye worm) TK/ALK protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.3566 0.3545
Schistosoma mansoni tyrosine protein kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0188 0.3666 0.3646
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0123 0.2165 0.214
Echinococcus granulosus netrin receptor unc 5 0.0036 0.0196 0.0165
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0994 0.3421
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis lachesin 0.0066 0.0867 0.0837
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0706 0.4483
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Schistosoma mansoni nephrin related 0.0029 0.0037 0.0006
Echinococcus multilocularis protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis hemicentin 1 0.0066 0.0867 0.0837
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0123 0.2165 0.214
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0036 0.0189 0.0157
Onchocerca volvulus Tyrosine kinase homolog 0.0065 0.086 0.0831
Schistosoma mansoni septate junction protein 0.0036 0.0196 0.0207
Loa Loa (eye worm) hypothetical protein 0.0112 0.1913 0.1886
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0189 0.0198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Echinococcus multilocularis activated cdc42 kinase 1 0.0036 0.0189 0.0157
Trypanosoma brucei trypanothione reductase 0.0046 0.0421 0.0691
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0421 0.039
Loa Loa (eye worm) hypothetical protein 0.0466 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1579 0.1551
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0036 0.0189 0.0157
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0196 0.0323
Brugia malayi Raf kinase 0.0036 0.0189 0.0157
Echinococcus granulosus raf serine:threonine protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0173 0.0177
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis protein tyrosine kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Brugia malayi integrin-linked kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Echinococcus multilocularis tyrosine protein kinase shark 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Brugia malayi Prion-like- 0.0029 0.0037 0.0005
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0189 0.0198
Echinococcus granulosus anosmin 1 0.0123 0.2165 0.214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0377 0.7967 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0123 0.2165 0.3559
Echinococcus multilocularis GPCR, family 2 0.0031 0.0066 0.0034
Schistosoma mansoni netrin receptor unc5 0.0036 0.0196 0.0207
Loa Loa (eye worm) TK/CSK protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus cell adhesion molecule 0.0123 0.2165 0.214
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/DDR protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0123 0.2165 0.3559
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Brugia malayi Immunoglobulin domain containing protein 0.0036 0.0196 0.0165
Mycobacterium tuberculosis Probable reductase 0.0105 0.1772 0.1814
Brugia malayi Disorganized muscle protein 1 0.0029 0.0037 0.0005
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1525 0.1497
Loa Loa (eye worm) serine/threonine protein kinase 0.0036 0.0189 0.0157
Brugia malayi hypothetical protein 0.0036 0.0196 0.0165
Brugia malayi Pre-SET motif family protein 0.0409 0.8705 0.8701
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.204 0.2089
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0189 0.0157
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Schistosoma mansoni cell adhesion molecule 0.0271 0.5542 0.6944
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0189 0.0198
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Onchocerca volvulus 0.0071 0.0994 0.0965
Loa Loa (eye worm) LAD-2 short isoform 0.0036 0.0196 0.0165
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2843 0.282
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0706 0.0849
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK protein kinase 0.0065 0.086 0.083
Echinococcus multilocularis tyrosine kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis survival motor neuron protein 1 0.0466 1 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Schistosoma mansoni septate junction protein 0.0066 0.0867 0.1052
Schistosoma mansoni cell adhesion molecule 0.0188 0.3666 0.458
Schistosoma mansoni cell adhesion molecule 0.0029 0.0037 0.0006
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.6085 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1525 0.1498
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) animal heme peroxidase 0.0029 0.0037 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0144 0.2661 0.3313
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0097 0.1574 0.2587
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0189 0.000000057217
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0994 0.1633
Brugia malayi Prion-like- 0.0066 0.0867 0.0837
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0123 0.2165 0.2688
Schistosoma mansoni roundabout 0.0066 0.0867 0.1052
Brugia malayi Receptor family ligand binding region containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0112 0.1913 0.1886
Echinococcus granulosus titin 0.0152 0.2843 0.282
Echinococcus multilocularis down syndrome cell adhesion 0.0029 0.0037 0.0005
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0036 0.0189 0.0198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0377 0.7967 0.796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0377 0.7967 1
Brugia malayi jmjC domain containing protein 0.0035 0.0173 0.0141
Schistosoma mansoni hemicentin 0.0152 0.2836 0.3534
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0043
Loa Loa (eye worm) myotactin form A 0.0123 0.2165 0.214
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0152 0.2836 0.2813
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus GPCR family 2 0.0031 0.0066 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1772 0.1814
Onchocerca volvulus 0.0123 0.2165 0.2141
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0188 0.3666 0.3646
Schistosoma mansoni eyes absent homolog 0.0086 0.1334 0.1641
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Onchocerca volvulus 0.0036 0.0189 0.0157
Giardia lamblia Kinase, NEK 0.0036 0.0189 0.1203
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0123 0.2165 0.2688
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0994 0.0965
Schistosoma mansoni hypothetical protein 0.0152 0.2836 0.3534
Brugia malayi MH2 domain containing protein 0.0233 0.4695 0.4678
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0123 0.2165 0.2688
Echinococcus multilocularis peroxidasin 0.0066 0.0867 0.0837
Loa Loa (eye worm) one IG domain family member 0.0029 0.0037 0.0005
Echinococcus multilocularis tyrosine protein kinase otk 0.0066 0.0867 0.0837
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni factor for adipocyte differentiation 0.0123 0.2165 0.2688
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1772 0.1814
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0034
Echinococcus granulosus neuroglian 0.0141 0.2583 0.2559
Echinococcus multilocularis usherin 0.0123 0.2165 0.214
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0159 0.2996 0.2973
Echinococcus granulosus neuroglian 0.0188 0.3666 0.3646
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.3566 0.3545
Echinococcus granulosus protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus Immunoglobulin 0.0036 0.0196 0.0165
Leishmania major branched-chain amino acid aminotransferase, putative 0.0097 0.1574 0.2587
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0123 0.2165 0.214
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.5
Schistosoma mansoni hypothetical protein 0.0123 0.2165 0.2688
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0148 0.2743 0.2719
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Echinococcus granulosus geminin 0.0347 0.7292 0.7284
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1525 0.1881
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0377 0.7967 0.796
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0036 0.0189 0.0157
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Branched-chain amino acid transaminase IlvE 0.0097 0.1574 0.1612
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0188 0.3666 0.3646
Echinococcus granulosus titin 0.0029 0.0037 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.2207 0.2182
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0189 0.0157
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Schistosoma mansoni myosin-binding protein-related 0.0152 0.2836 0.3534
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Loa Loa (eye worm) hypothetical protein 0.0077 0.1117 0.1088
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0189 0.0198
Brugia malayi basement membrane proteoglycan precursor 0.0036 0.0196 0.0165
Onchocerca volvulus 0.0071 0.0994 0.0965
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1579 0.1551
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1525 0.2506
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0037 0.0005
Mycobacterium ulcerans hypothetical protein 0.0155 0.2905 1
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Schistosoma mansoni kinase 0.0048 0.0463 0.0543
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0188 0.3666 0.458
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus tyrosine protein kinase otk 0.0066 0.0867 0.0837
Trichomonas vaginalis set domain proteins, putative 0.0466 0.9995 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0036 0.0189 0.0157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0656 0.0626
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0189 0.0198
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0514 0.0483
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0036 0.0189 0.0157
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.1117 0.1088
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.204 0.2089
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0994 0.1018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0377 0.7967 0.796
Echinococcus multilocularis Immunoglobulin 0.0112 0.1913 0.1886
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Echinococcus granulosus tyrosine kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) CAMK protein kinase 0.0152 0.2843 0.282
Schistosoma mansoni thyroid hormone receptor 0.0144 0.2661 0.3313
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Onchocerca volvulus 0.0029 0.0037 0.0005
Brugia malayi Lethal protein 805 0.0123 0.2165 0.214
Toxoplasma gondii STE kinase 0.0036 0.0189 0.1203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0234 0.4712 0.4695
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0514 0.0526
Brugia malayi beta-lactamase family protein 0.0071 0.0994 0.0965
Echinococcus granulosus roundabout 2 0.0188 0.3666 0.3646
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0037 0.0005
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0036 0.0189 0.0157
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0066 0.0867 0.1052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Toxoplasma gondii protein kinase domain-containing protein 0.0036 0.0189 0.1203
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0029 0.0037 0.0005
Trypanosoma brucei Pseudokinase, putative 0.0036 0.0189 0.0311
Echinococcus granulosus hemicentin 1 0.0066 0.0867 0.0837
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0189 0.0198
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Giardia lamblia PHD finger protein 15 0.0029 0.0032 0.0206
Echinococcus multilocularis Immunoglobulin 0.0036 0.0196 0.0165
Schistosoma mansoni slit 0.0029 0.0037 0.0006
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0177 0.3414 0.3392
Schistosoma mansoni septate junction protein 0.0066 0.0867 0.1052
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) protein kinase domain-containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0036 0.0196 0.0165
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis insulin growth factor binding 0.0029 0.0037 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0165
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0043
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Brugia malayi hypothetical protein 0.0123 0.2165 0.214
Echinococcus multilocularis transfer RNA-Thr 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.204 0.2089
Echinococcus multilocularis natriuretic peptide receptor 1 0.0036 0.0189 0.0157
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0036 0.0189 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0173 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Echinococcus granulosus titin 0.0029 0.0037 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0036 0.0189 0.0157
Echinococcus multilocularis 0.0029 0.0037 0.0005
Echinococcus multilocularis hemicentin 1 0.0066 0.0867 0.0837
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0189 0.0157
Mycobacterium ulcerans hypothetical protein 0.0071 0.0994 0.3421
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0994 0.0821
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1525 0.2506
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1525 0.2506
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Plasmodium falciparum tyrosine kinase-like protein 0.0036 0.0189 0.1695
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Schistosoma mansoni hypothetical protein 0.0347 0.7292 0.915
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus down syndrome cell adhesion 0.0029 0.0037 0.0005
Brugia malayi Branched-chain amino acid aminotransferase, cytosolic, putative 0.0097 0.1574 0.1547
Brugia malayi Prion-like- 0.0029 0.0037 0.0005
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0123 0.2165 0.2141
Schistosoma mansoni hypothetical protein 0.0036 0.0189 0.0198
Echinococcus multilocularis titin 0.0123 0.2165 0.214
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0148 0.2743 0.2719
Onchocerca volvulus 0.0029 0.0037 0.0005
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Onchocerca volvulus 0.0123 0.2165 0.2141
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0189 0.0198
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0994 0.1018
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0066 0.0867 0.0838
Echinococcus granulosus anosmin 1 0.0123 0.2165 0.214
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Schistosoma mansoni factor for adipocyte differentiation 0.0123 0.2165 0.2688
Loa Loa (eye worm) hypothetical protein 0.0097 0.1579 0.1551
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0994 0.1018
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Trypanosoma cruzi protein kinase, putative 0.0036 0.0189 0.0311
Schistosoma mansoni jumonji domain containing protein 0.0076 0.11 0.1345
Loa Loa (eye worm) TK/EPH protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0189 0.3673 0.3653
Entamoeba histolytica ankyrin repeat protein 0.0036 0.0189 0.00000040515
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0994 0.1018
Entamoeba histolytica protein kinase, putative 0.0036 0.0189 0.00000040515
Brugia malayi glutathione reductase 0.0046 0.0421 0.039
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin domain containing protein 0.0036 0.0196 0.0165
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0377 0.7967 0.796
Brugia malayi beta-lactamase family protein 0.0071 0.0994 0.0965
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0994 0.1633
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0123 0.2165 0.214
Onchocerca volvulus 0.0059 0.0706 0.0676
Loa Loa (eye worm) SRC-1 0.0036 0.0189 0.0157
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0043
Onchocerca volvulus 0.0036 0.0189 0.0157
Leishmania major trypanothione reductase 0.0046 0.0421 0.0691
Entamoeba histolytica protein kinase domain containing protein 0.0036 0.0196 0.0051
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0036 0.0189 0.0157
Trypanosoma brucei protein kinase, putative 0.0036 0.0196 0.0323
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1117 0.7096
Echinococcus granulosus defective proboscis extension response 0.0112 0.1913 0.1886
Mycobacterium ulcerans beta-lactamase 0.0071 0.0994 0.3421
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0066 0.0867 0.0837
Schistosoma mansoni titin 0.0029 0.0037 0.0006
Schistosoma mansoni titin 0.0029 0.0037 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0032 0.0206
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0036 0.0189 0.000000057217
Schistosoma mansoni survival motor neuron protein 0.0095 0.1535 0.1894
Schistosoma mansoni protein tyrosine phosphatase 0.0123 0.2165 0.2688
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0196 0.0207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0196 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0044 0.0015
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0189 0.0157
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Trypanosoma brucei polo-like protein kinase 0.0095 0.1525 0.2506
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Schistosoma mansoni neuroglian 0.0188 0.3666 0.458
Schistosoma mansoni titin 0.0029 0.0037 0.0006
Echinococcus multilocularis activin receptor type 0.0036 0.0196 0.0164
Brugia malayi Immunoglobulin I-set domain containing protein 0.0188 0.3666 0.3646
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0994 0.8899
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Echinococcus granulosus fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0043
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.086 0.083
Echinococcus granulosus leucine rich repeat containing protein 4 0.0029 0.0037 0.0005
Brugia malayi Leucine Rich Repeat family protein 0.0029 0.0037 0.0005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1548 0.1521
Echinococcus multilocularis titin 0.0029 0.0037 0.0005
Brugia malayi hypothetical protein 0.0036 0.0189 0.0157
Brugia malayi myotactin form B 0.0123 0.2165 0.214
Schistosoma mansoni ephrin receptor 0.0159 0.2989 0.3726
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) hypothetical protein 0.0066 0.0879 0.0849
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0029 0.0037 0.0005
Schistosoma mansoni basigin related 0.0036 0.0196 0.0207
Schistosoma mansoni hypothetical protein 0.0095 0.1535 0.1894
Plasmodium falciparum phd finger protein, putative 0.0029 0.0032 0.029
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0036 0.0196 0.0164
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0311 0.0511
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0123 0.2165 0.214
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.0189 0.0157
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0036 0.0196 0.0165
Loa Loa (eye worm) hypothetical protein 0.0152 0.2836 0.2813
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis cell adhesion molecule 0.0123 0.2165 0.214
Onchocerca volvulus 0.0036 0.0189 0.0157
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0097 0.1574 0.2587
Schistosoma mansoni titin 0.0029 0.0037 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.6085 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0189 0.0157
Giardia lamblia Kinase 0.0036 0.0189 0.1203
Brugia malayi C-terminal src kinase protein 1 0.0036 0.0189 0.0157
Mycobacterium leprae PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE 0.0097 0.1574 0.6947
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Echinococcus granulosus insulin receptor 0.0036 0.0189 0.0157
Echinococcus multilocularis anosmin 1 0.0123 0.2165 0.214
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0311 0.0511
Echinococcus multilocularis tyrosine protein kinase pr2 0.0036 0.0189 0.0157
Echinococcus multilocularis Immunoglobulin 0.0036 0.0196 0.0165
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0159 0.2989 0.2966
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0173 0.0141
Onchocerca volvulus 0.0029 0.0037 0.0005
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Abl 0.0036 0.0189 0.0157
Schistosoma mansoni protein kinase 0.0036 0.0196 0.0207
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.3844
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0029 0.0037 0.0005
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0029 0.0037 0.0005
Echinococcus multilocularis receptor type guanylyl cyclase 0.0036 0.0189 0.0157
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1548 0.1521
Brugia malayi Prion-like- 0.0029 0.0037 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0518 0.0851
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0097 0.1574 0.2587
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0994 0.0965
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0293 0.0262
Plasmodium falciparum thioredoxin reductase 0.0046 0.0421 0.3767
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0165
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/ROR protein kinase 0.0065 0.086 0.083
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0189 0.0157
Brugia malayi beta-lactamase 0.0071 0.0994 0.0965
Trichomonas vaginalis subgroup IIIi aminotransferase, putative 0.0097 0.1574 0.1412
Brugia malayi Thioredoxin reductase 0.0046 0.0421 0.039
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0029 0.0037 0.0005
Onchocerca volvulus 0.0123 0.2165 0.2141
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0189 0.0157
Echinococcus granulosus receptor type guanylyl cyclase 0.0036 0.0189 0.0157
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Echinococcus granulosus roundabout 2 0.0188 0.3666 0.3646
Brugia malayi Fibronectin type III domain containing protein 0.0234 0.4712 0.4695
Loa Loa (eye worm) lethal protein 805 0.0123 0.2165 0.214
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0065 0.086 0.083
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) projectin 0.0152 0.2836 0.2813
Brugia malayi Immunoglobulin domain containing protein 0.0036 0.0196 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.4695 0.4678
Echinococcus multilocularis integrin linked protein kinase 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0152 0.2836 0.2814
Loa Loa (eye worm) hypothetical protein 0.0112 0.1913 0.1886
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2546 0.4184
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0189 0.000000057217
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.2836 0.2813
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.1117 0.1367
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1772 0.1814
Brugia malayi Probable ClpP-like protease 0.0077 0.1117 0.1088
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0742 0.0712
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Conserved protein 0.0071 0.0994 0.1018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0188 0.3666 0.3646
Giardia lamblia Branched-chain amino acid aminotransferase lateral transfer candidate 0.0097 0.1574 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0034
Echinococcus multilocularis raf serine:threonine protein kinase 0.0036 0.0189 0.0157
Brugia malayi Tyrosine-protein kinase PR2 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0994 0.1018
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0066 0.0867 0.0837
Plasmodium falciparum protein kinase, putative 0.0036 0.0189 0.1695
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Entamoeba histolytica protein kinase, putative 0.0036 0.0189 0.00000040515
Schistosoma mansoni hypothetical protein 0.0066 0.0879 0.1067
Echinococcus granulosus low density lipoprotein receptor ldl 0.0036 0.0196 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0189 0.0198
Schistosoma mansoni titin 0.0152 0.2836 0.3534
Brugia malayi Guanylyl cyclase protein 23 0.0036 0.0189 0.0157
Echinococcus multilocularis twitchin 0.003 0.0044 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Toxoplasma gondii hypothetical protein 0.0047 0.045 0.2858
Plasmodium vivax tyrosine kinase-like protein, putative 0.0036 0.0189 0.1695
Echinococcus granulosus Fibronectin type III 0.0123 0.2165 0.214
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0036 0.0196 0.0207
Echinococcus granulosus tyrosine kinase 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Plasmodium vivax SET domain protein, putative 0.0059 0.0706 0.6319
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0994 0.1018
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0421 0.039
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0032 0.029
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0152 0.2836 0.2813
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0123 0.2165 0.214
Echinococcus granulosus activin receptor type 0.0036 0.0196 0.0164
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0036 0.0196 0.0165
Echinococcus granulosus tyrosine protein kinase Lyn 0.0036 0.0196 0.0164
Schistosoma mansoni nephrin 0.0264 0.5383 0.6743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Plasmodium falciparum protein kinase, putative 0.0036 0.0196 0.1758
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0311 0.0511
Loa Loa (eye worm) hypothetical protein 0.0086 0.1334 0.1306
Schistosoma mansoni tripartite motif protein trim9 0.0123 0.2165 0.2688
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0189 0.0157
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0036 0.0196 0.0323
Brugia malayi Furin-like cysteine rich region family protein 0.0036 0.0189 0.0157
Echinococcus granulosus Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Echinococcus granulosus basement membrane specific heparan sulfate 0.0036 0.0196 0.0165
Echinococcus multilocularis Fibronectin, type III 0.0123 0.2165 0.214
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Brugia malayi hypothetical protein 0.0234 0.4712 0.4695
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0435 0.025
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0189 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0994 0.0821
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0189 0.0157
Brugia malayi Pre-SET motif family protein 0.0059 0.0706 0.0675
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.2546 0.4184
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Echinococcus multilocularis ephrin type A receptor 4 A 0.0036 0.0189 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0994 0.0821
Schistosoma mansoni hypothetical protein 0.0123 0.2165 0.2688
Onchocerca volvulus 0.0123 0.2165 0.2141
Schistosoma mansoni tyrosine kinase 0.0102 0.169 0.2089
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0994 0.3146
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Onchocerca volvulus 0.0123 0.2165 0.2141
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0514 0.0483
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0037 0.0005
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Brugia malayi Myb-like DNA-binding domain containing protein 0.0029 0.0037 0.0005
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0036 0.0196 0.0164
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.1117 1
Onchocerca volvulus 0.0036 0.0189 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0994 0.1212
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0036 0.0196 0.0207
Onchocerca volvulus 0.0036 0.0189 0.0157
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0189 0.000000057217
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Brugia malayi protein unc-22 0.0152 0.2843 0.282
Onchocerca volvulus 0.0029 0.0037 0.0005
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1525 0.1497
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0029 0.0037 0.0006
Schistosoma mansoni basigin related 0.0036 0.0196 0.0207
Onchocerca volvulus 0.0123 0.2165 0.2141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0994 0.1212
Schistosoma mansoni protein kinase 0.0036 0.0196 0.0207
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0311 0.0511
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Schistosoma mansoni peroxidasin 0.0036 0.0196 0.0207
Onchocerca volvulus 0.0095 0.1535 0.1508
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0188 0.3666 0.3646
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0196 0.0207
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0994 0.1018
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Echinococcus granulosus nephrin 0.0152 0.2836 0.2813
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Onchocerca volvulus 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1117 0.5
Onchocerca volvulus 0.0029 0.0037 0.0005
Echinococcus granulosus titin 0.0029 0.0037 0.0005
Onchocerca volvulus Peroxidasin homolog 0.0029 0.0037 0.0005
Onchocerca volvulus 0.0123 0.2165 0.2141
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0065 0.086 0.083
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0123 0.2165 0.214
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Echinococcus multilocularis neuroglian 0.0188 0.3666 0.3646
Brugia malayi SPRY domain containing protein 0.0123 0.2165 0.214
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0123 0.2165 0.2688
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0036 0.0196 0.0165
Echinococcus multilocularis Netrin receptor DCC 0.0123 0.2165 0.214
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0036 0.0189 0.0157
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0189 0.0157
Plasmodium falciparum protein kinase, putative 0.0036 0.0189 0.1695
Toxoplasma gondii protein kinase 0.0036 0.0189 0.1203
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0037 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0706 0.0849
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0152 0.2836 0.2813
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0036 0.0189 0.0157
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Toxoplasma gondii Branched-chain-amino-acid aminotransferase 0.0097 0.1574 1
Echinococcus granulosus tyrosine protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni protein tyrosine kinase 0.0036 0.0189 0.0198
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0123 0.2165 0.214
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1772 0.8241
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Brugia malayi myotactin form A 0.0123 0.2165 0.214
Brugia malayi bone morphogenetic protein type 1 receptor 0.0036 0.0189 0.0157
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0036 0.0196 0.0207
Loa Loa (eye worm) branched-chain amino acid aminotransferase 0.0097 0.1574 0.1547
Giardia lamblia Kinase, NEK 0.0036 0.0189 0.1203
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0189 0.0157
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0293 0.0262
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0036 0.0189 0.0157
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0123 0.2165 0.3559
Loa Loa (eye worm) hypothetical protein 0.0152 0.2836 0.2813
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Loa Loa (eye worm) TK/ABL protein kinase 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Schistosoma mansoni ephrin receptor 0.0036 0.0189 0.0198
Schistosoma mansoni titin 0.0066 0.0867 0.1052
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) disorganized muscle protein 1 0.0029 0.0037 0.0005
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0173 0.0141
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0994 0.1633
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0123 0.2165 0.214
Onchocerca volvulus 0.0123 0.2165 0.2141
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0706 0.0675
Schistosoma mansoni hypothetical protein 0.0347 0.7292 0.915
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0165
Echinococcus granulosus Immunoglobulin subtype 0.0036 0.0196 0.0165
Echinococcus multilocularis insulin receptor 0.0036 0.0189 0.0157
Brugia malayi Peroxidasin 0.0066 0.0867 0.0837
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0165
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Schistosoma mansoni hypothetical protein 0.0029 0.0037 0.0006
Echinococcus granulosus G1Y162 protein 0.0123 0.2165 0.214
Echinococcus multilocularis netrin receptor unc 5 0.0036 0.0196 0.0165
Echinococcus granulosus natriuretic peptide receptor 1 0.0036 0.0189 0.0157
Echinococcus granulosus integrin linked protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0059 0.0706 0.0675
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0196 0.0165
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1772 0.1814
Onchocerca volvulus 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0066 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0037 0.0005
Onchocerca volvulus 0.0029 0.0037 0.0005
Echinococcus multilocularis Immunoglobulin subtype 0.0036 0.0196 0.0165
Brugia malayi kettin 0.0029 0.0037 0.0005
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0189 0.0157
Entamoeba histolytica branched-chain amino acid aminotransferase, putative 0.0097 0.1574 1
Echinococcus granulosus usherin 0.0123 0.2165 0.214
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0159 0.2996 0.2973
Echinococcus multilocularis geminin 0.0347 0.7292 0.7284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0066 0.0867 0.0837
Echinococcus granulosus anosmin 1 0.0123 0.2165 0.214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Schistosoma mansoni cell adhesion molecule 0.0036 0.0196 0.0207
Plasmodium falciparum glutathione reductase 0.0046 0.0421 0.3767
Echinococcus multilocularis anosmin 1 0.0123 0.2165 0.214
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0196 0.0165
Trichomonas vaginalis esterase, putative 0.0071 0.0994 0.0821
Schistosoma mansoni protein kinase 0.0036 0.0189 0.0198
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1772 0.1814
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1579 0.1551
Brugia malayi Fibronectin type III domain containing protein 0.0123 0.2165 0.214
Schistosoma mansoni cell adhesion molecule 0.0152 0.2836 0.3534
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus granulosus twitchin 0.0141 0.259 0.2566
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Trypanosoma cruzi protein kinase, putative 0.0036 0.0189 0.0311
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198
Loa Loa (eye worm) hypothetical protein 0.0066 0.0867 0.0837
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0123 0.2165 0.2141
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0188 0.3666 0.3646
Brugia malayi protein-tyrosine kinase 0.0036 0.0189 0.0157
Schistosoma mansoni nephrin 0.0188 0.3666 0.458
Onchocerca volvulus 0.0036 0.0189 0.0157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0034
Loa Loa (eye worm) beta-lactamase 0.0071 0.0994 0.0965
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Echinococcus multilocularis Netrin receptor DCC 0.0123 0.2165 0.214
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0152 0.2836 0.2813
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0036 0.0189 0.0311
Toxoplasma gondii thioredoxin reductase 0.0046 0.0421 0.2673
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0189 0.0157
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0123 0.2165 0.214
Brugia malayi hypothetical protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0188 0.3666 0.3646
Schistosoma mansoni nephrin related 0.0036 0.0196 0.0207
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK/RYK protein kinase 0.0036 0.0189 0.0157
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0189 0.0157
Brugia malayi hypothetical protein 0.0086 0.1334 0.1306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0165
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0159 0.2996 0.2973
Brugia malayi Lethal protein 805 0.0123 0.2165 0.214
Leishmania major hypothetical protein, conserved 0.0123 0.2165 0.3559
Brugia malayi SH2 domain containing protein 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0066 0.0034
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0032 0.0206
Brugia malayi basement membrane proteoglycan 0.0036 0.0196 0.0165
Loa Loa (eye worm) hypothetical protein 0.0071 0.0994 0.0965
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0409 0.8705 0.8701
Leishmania major hypothetical protein, conserved 0.0071 0.0994 0.1633
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0036 0.0189 0.0157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0066 0.0034
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0152 0.2836 0.2814
Echinococcus granulosus Immunoglobulin 0.0112 0.1913 0.1886
Echinococcus granulosus Immunoglobulin 0.0036 0.0196 0.0165
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0706 0.0675
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0036 0.0189 0.0157
Schistosoma mansoni factor for adipocyte differentiation 0.0123 0.2165 0.2688
Loa Loa (eye worm) hypothetical protein 0.0086 0.1334 0.1306
Leishmania major protein kinase, putative 0.0036 0.0189 0.0311
Schistosoma mansoni serine/threonine RGC 0.0036 0.0189 0.0198
Schistosoma mansoni cell adhesion molecule 0.0036 0.0196 0.0207
Echinococcus granulosus Netrin receptor DCC 0.0123 0.2165 0.214
Onchocerca volvulus 0.0036 0.0189 0.0157
Brugia malayi Protein kinase domain containing protein 0.0036 0.0189 0.0157
Schistosoma mansoni netrin receptor unc5 0.0036 0.0196 0.0207
Echinococcus multilocularis tyrosine protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0177 0.3414 0.3392
Echinococcus granulosus tyrosine protein kinase ABL1 0.0036 0.0189 0.0157
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0377 0.7967 0.796
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0435 0.025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0994 0.0965
Loa Loa (eye worm) TK/ACK protein kinase 0.0036 0.0189 0.0157
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0879 0.0849
Onchocerca volvulus 0.0029 0.0037 0.0005
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0123 0.2165 0.3559
Onchocerca volvulus 0.0152 0.2843 0.2821
Leishmania major hypothetical protein, conserved 0.0036 0.0189 0.0311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0036 0.0189 0.0157
Onchocerca volvulus 0.0071 0.0994 0.0965
Loa Loa (eye worm) TK/INSR protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine kinase 0.0036 0.0189 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0706 0.0849
Echinococcus granulosus titin 0.0152 0.2843 0.282
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0029 0.0037 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0421 0.039
Loa Loa (eye worm) TK protein kinase 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0189 0.0157
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0189 0.0157
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0157
Mycobacterium tuberculosis Conserved protein 0.0071 0.0994 0.1018
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.204 1
Mycobacterium ulcerans lipase LipD 0.0071 0.0994 0.3421
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0189 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0706 0.0849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0034
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0189 0.0198
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.2843 0.3543
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1525 0.1362
Schistosoma mansoni cell adhesion molecule 0.0188 0.3666 0.458
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0005
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1525 0.1497
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.4695 0.4678
Loa Loa (eye worm) hypothetical protein 0.0112 0.1913 0.1886
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.1117 0.3952
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.1535 0.1508
Brugia malayi ephrin receptor 1 precursor 0.0036 0.0189 0.0157
Brugia malayi Heparan sulfate 0.0036 0.0196 0.0165
Brugia malayi Immunoglobulin I-set domain containing protein 0.0234 0.4712 0.4695
Loa Loa (eye worm) hypothetical protein 0.0123 0.2165 0.214
Onchocerca volvulus 0.0466 0.9995 1
Echinococcus granulosus contactin 0.0188 0.3666 0.3646
Schistosoma mansoni tyrosine kinase 0.0036 0.0189 0.0198

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4 uM Cytotoxicity against Homo sapiens (human) DU145 cells assessed as inhibition of cell survival after 96 hr by MTT assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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