Detailed information for compound 208420

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.364 | Formula: C16H24N5O8P
  • H donors: 1 H acceptors: 4 LogP: 0.64 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(CC(=O)OCC)OCC1OC(CC1N=[N+]=[N-])n1cc(C)c(=O)[nH]c1=O
  • InChi: 1S/C16H24N5O8P/c1-4-26-14(22)9-30(25,27-5-2)28-8-12-11(19-20-17)6-13(29-12)21-7-10(3)15(23)18-16(21)24/h7,11-13H,4-6,8-9H2,1-3H3,(H,18,23,24)
  • InChiKey: BAJBRZZNLLYYCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Echinococcus granulosus serotonin transporter 0.2576 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0072 0.0436
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0437 0.1652 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0078 0.0424
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0044 0.026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0285 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0015 0.0107
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0087 0.0086
Brugia malayi putative neuropeptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0005
Trichomonas vaginalis esterase, putative 0.0036 0.0084 0.0476
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0437 0.1652 0.1651
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1114 0.4294 0.4293
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0191 0.0189
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0078 0.0424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0123 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.034 0.0339
Schistosoma mansoni vesicular acetylcholine transporter 0.0877 0.3369 0.3368
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.0191 0.0189
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0047 0.0128 0.0127
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.004 0.0102 0.0101
Schistosoma mansoni hypothetical protein 0.0032 0.007 0.0069
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0285 0.0284
Onchocerca volvulus 0.002 0.0022 0.0021
Echinococcus granulosus glutamate receptor NMDA 0.0079 0.0253 0.0252
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0021
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis sex peptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus fmrfamide receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0397 0.0396
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0015 0.0107
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0192 0.0191
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0285 0.0284
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0191 0.0189
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0191 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0229
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.0634
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0084 0.0503
Onchocerca volvulus 0.0063 0.0191 0.0189
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0203 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0285 0.0284
Schistosoma mansoni hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0437 0.1652 0.1651
Echinococcus multilocularis 0.0018 0.0015 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.037 0.3012
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.0145 0.0328
Echinococcus multilocularis NMDA receptor 0.0054 0.0158 0.0157
Onchocerca volvulus 0.0063 0.0191 0.0189
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0072 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.007 0.0069
Schistosoma mansoni hypothetical protein 0.0032 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Echinococcus multilocularis nmda type glutamate receptor 0.0133 0.0466 0.0464
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0047 0.0128 0.0127
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0005 0.0003
Echinococcus multilocularis serotonin receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) doublecortin family protein 0.002 0.0022 0.0021
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.037 0.0368
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0166 0.0592 0.0591
Echinococcus granulosus g protein coupled receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis G protein coupled receptor 139 0.0063 0.0191 0.0189
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Brugia malayi 6-phosphofructokinase 0.0109 0.037 0.0368
Brugia malayi hypothetical protein 0.0437 0.1652 0.1651
Brugia malayi TAR-binding protein 0.0063 0.0192 0.0191
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.0566 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0084 0.0182
Schistosoma mansoni Lamin B receptor (ERG24) 0.0099 0.033 0.0329
Loa Loa (eye worm) inositol-1 0.0036 0.0087 0.0086
Brugia malayi Abnormal catecholamine distribution protein 1 0.112 0.4319 0.4318
Giardia lamblia PHD finger protein 15 0.0032 0.0072 0.0105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0022 0.013
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0285 0.0284
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0021
Onchocerca volvulus 0.0047 0.0128 0.0127
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0087 0.1314
Brugia malayi Cytochrome P450 family protein 0.0027 0.0049 0.0048
Schistosoma mansoni acetylcholine receptor subunit beta 0.004 0.0102 0.0101
Schistosoma mansoni hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0005
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.0145 0.0328
Echinococcus granulosus lamin 0.0027 0.005 0.0049
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0099 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.007 0.0069
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0015 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0015 0.0107
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Brugia malayi Glutamate receptor 1 precursor 0.0147 0.052 0.0518
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.0285 0.0284
Schistosoma mansoni vesicular amine transporter 0.112 0.4319 0.4318
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0015 0.0005 0.0003
Echinococcus granulosus metabotropic glutamate receptor 2 0.0015 0.0005 0.0003
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.0191 0.0189
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0072 0.0071
Echinococcus granulosus lamin b receptor 0.0099 0.033 0.0329
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.1114 0.4294 0.4293
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0092 0.1044
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0049 0.0103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0092 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0437 0.1652 0.1651
Onchocerca volvulus 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0084 0.0944
Leishmania major C-14 sterol reductase, putative 0.0099 0.033 0.0759
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni lamin 0.0027 0.005 0.0049
Schistosoma mansoni amine GPCR 0.0063 0.0191 0.0189
Echinococcus granulosus sex peptide receptor 0.0063 0.0191 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.037 0.2879
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0015 0.0107
Onchocerca volvulus 0.0063 0.0191 0.0189
Loa Loa (eye worm) acetylcholine receptor protein 0.004 0.0102 0.0101
Onchocerca volvulus 0.2576 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0001 0.0000000032544
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.0191 0.0189
Schistosoma mansoni hypothetical protein 0.0672 0.2567 0.2566
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0437 0.1652 0.1651
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0579 0.0578
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.0191 0.0189
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Toxoplasma gondii exonuclease III APE 0.0038 0.0092 0.0557
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0047 0.0128 0.0127
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.0191 0.0189
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0006 0.0032
Echinococcus granulosus sodium and chloride dependent glycine 0.0437 0.1652 0.1651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0005 0.0003
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0102 0.0101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0084 0.1253
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0285 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0084 0.0944
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.0003
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0027 0.0026
Onchocerca volvulus 0.0063 0.0191 0.0189
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.0191 0.0189
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.0191 0.0189
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0015 0.0023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.037 0.0368
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.0191 0.0189
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0437 0.1652 0.1651
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0084 0.1253
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0229
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.037 0.0848
Onchocerca volvulus 0.0159 0.0566 0.0565
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.0191 0.0189
Brugia malayi hypoxia-induced factor 1 0.0153 0.0542 0.0541
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0191 0.0189
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis nmda type glutamate receptor 0.0094 0.0313 0.0311
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0087 0.0086
Echinococcus granulosus g-protein coupled receptor 0.0063 0.0191 0.0189
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.037 0.0368
Loa Loa (eye worm) cytochrome P450 0.0018 0.0015 0.0013
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0437 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.0566 0.0565
Onchocerca volvulus Putative nachr subunit 0.0087 0.0285 0.0284
Leishmania major protein kinase, putative 0.0018 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Schistosoma mansoni amine GPCR 0.0063 0.0191 0.0189
Brugia malayi hypothetical protein 0.0025 0.0044 0.0042
Brugia malayi hypothetical protein 0.002 0.0022 0.0021
Brugia malayi hypothetical protein 0.0015 0.0005 0.0003
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.006 0.0358
Echinococcus granulosus intermediate filament protein 0.0027 0.005 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0123 0.0121
Toxoplasma gondii hypothetical protein 0.0437 0.1652 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Brugia malayi beta-lactamase family protein 0.0036 0.0084 0.0082
Echinococcus granulosus tm gpcr rhodopsin 0.0565 0.215 0.2149
Echinococcus granulosus lamin dm0 0.0027 0.005 0.0049
Schistosoma mansoni glutamate receptor AMPA 0.0147 0.052 0.0518
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0001 0.0000000032544
Brugia malayi G-protein coupled receptor 0.0063 0.0191 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.006 0.0362
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) intermediate filament protein 0.0027 0.005 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0084 0.0944
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0063 0.0191 0.0189
Brugia malayi cytochrome P450 0.0018 0.0015 0.0013
Echinococcus multilocularis glutamate receptor 2 0.0108 0.0367 0.0365
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0006 0.0036
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0087 0.0285 0.0284
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0203 0.0462
Schistosoma mansoni loxhd1 0.002 0.0022 0.0021
Onchocerca volvulus 0.0087 0.0285 0.0284
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0128 0.0127
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Treponema pallidum sodium- and chloride- dependent transporter 0.2576 1 1
Schistosoma mansoni neuropeptide receptor 0.0063 0.0191 0.0189
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0437 0.1652 0.1651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0092 0.0204
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.0191 0.0189
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni hypothetical protein 0.0035 0.0081 0.008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0437 0.1652 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0044 0.0264
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Brugia malayi Dopamine receptor protein 2 0.0063 0.0191 0.0189
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0087 0.0285 0.0284
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.0191 0.0189
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0088 0.1329
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0054 0.0158 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0084 0.0476
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.0191 0.0189
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0159 0.0566 0.0565
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0191 0.0189
Schistosoma mansoni sodium-dependent amino acid transporter 0.0437 0.1652 0.1651
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0087 0.0285 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0293 0.1089 0.1087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.0566 0.6791
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Mycobacterium ulcerans lipase LipD 0.0036 0.0084 0.1253
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0123 0.0121
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.0191 0.0189
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) RNA binding protein 0.0063 0.0192 0.0191
Loa Loa (eye worm) hypothetical protein 0.0056 0.0163 0.0161
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0087 0.0504
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0084 0.0476
Brugia malayi GnHR receptor homolog 0.0063 0.0191 0.0189
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0072 0.0071
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.037 0.0368
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1114 0.4294 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0087 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Echinococcus multilocularis tyrosine kinase 0.0015 0.0005 0.0003
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0437 0.1652 0.1651
Plasmodium vivax amine transporter, putative 0.0437 0.1652 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.006 0.0358
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0191 0.0189
Trypanosoma cruzi C-14 sterol reductase, putative 0.0099 0.033 0.0759
Echinococcus granulosus glutamate NMDA receptor subunit 0.0313 0.1166 0.1165
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0406 0.0404
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0406 0.0404
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.0191 0.0189
Brugia malayi hypothetical protein 0.004 0.0102 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0072 0.0432
Mycobacterium ulcerans hypothetical protein 0.0036 0.0084 0.1253
Schistosoma mansoni tyrosine kinase 0.0015 0.0005 0.0003
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.2554 0.9916 0.9916
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0087 0.0504
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0015 0.0023
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0397 0.0396
Onchocerca volvulus 0.0036 0.0084 0.0082
Leishmania major sterol C-24 reductase, putative 0.0051 0.0145 0.0328
Brugia malayi intermediate filament protein 0.0027 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus g protein coupled receptor 0.0063 0.0191 0.0189
Echinococcus granulosus orexin receptor type 2 0.0063 0.0191 0.0189
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0087 0.0285 0.0284
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0015 0.0005 0.0003
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.0191 0.0189
Echinococcus granulosus GPCR family 2 0.0032 0.007 0.0069
Leishmania major cytochrome p450-like protein 0.0018 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0054 0.0158 0.0157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0084 0.0082
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.006 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0021
Echinococcus granulosus neuropeptide receptor 0.0063 0.0191 0.0189
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0092 0.0201
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni amine GPCR 0.0063 0.0191 0.0189
Brugia malayi Serotonin receptor 0.0063 0.0191 0.0189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0102 0.0101
Echinococcus multilocularis serotonin receptor 0.0063 0.0191 0.0189
Echinococcus granulosus neuropeptide receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni lipoxygenase 0.0118 0.0406 0.0404
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.037 0.3012
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0015 0.0107
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Onchocerca volvulus 0.0437 0.1652 0.1651
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0285 0.0284
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0005 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Brugia malayi G-protein coupled receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) LGC-31 protein 0.0087 0.0285 0.0284
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.0191 0.0189
Schistosoma mansoni lamin 0.0027 0.005 0.0049
Echinococcus multilocularis RUN 0.002 0.0022 0.0021
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.037 0.2879
Loa Loa (eye worm) glutamate receptor 2 0.0147 0.052 0.0518
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis allatostatin A receptor 0.0063 0.0191 0.0189
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.0191 0.0189
Echinococcus granulosus serotonin receptor 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0015 0.0107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni cytochrome P450 0.0018 0.0015 0.0013
Onchocerca volvulus 0.0063 0.0191 0.0189
Brugia malayi Death domain containing protein 0.0014 0.0001 0.0000000032544
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0162 0.0579 0.0578
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0054 0.0158 0.0157
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0191 0.0189
Onchocerca volvulus 0.004 0.0102 0.0101
Loa Loa (eye worm) phosphofructokinase 0.0109 0.037 0.0368
Echinococcus multilocularis glutamate receptor 2 0.0162 0.0579 0.0578
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0087 0.0504
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0006 0.0005
Echinococcus granulosus g protein coupled receptor 0.0063 0.0191 0.0189
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0087 0.0192
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0049 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0207 0.0206
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0191 0.0189
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0579 0.0578
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Schistosoma mansoni histamine h1 receptor 0.0063 0.0191 0.0189
Brugia malayi ORL1-like opioid receptor 0.0063 0.0191 0.0189
Brugia malayi Metabotropic glutamate receptor precursor. 0.0015 0.0005 0.0003
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0944
Entamoeba histolytica hypothetical protein 0.0047 0.0128 0.1021
Brugia malayi Latrophilin receptor protein 2 0.0032 0.007 0.0069
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0084 0.0944
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0087 0.0086
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.007 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0192 0.0191
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0285 0.0284
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0087 0.0285 0.0284
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.0191 0.0189
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0128 0.0127
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.2598 0.2597
Schistosoma mansoni intermediate filament proteins 0.0027 0.005 0.0049
Echinococcus granulosus synaptic vesicular amine transporter 0.112 0.4319 0.4318
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0049
Brugia malayi metabotropic glutamate receptor type 2 0.0015 0.0005 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.0191 0.0189
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0191 0.0189
Echinococcus granulosus glutamate receptor 2 0.0162 0.0579 0.0578
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0119 0.0409 0.0408
Echinococcus multilocularis lamin 0.0027 0.005 0.0049
Schistosoma mansoni biogenic amine receptor 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0037 0.0088 0.0087
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0021
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0437 0.1652 0.1651
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0191 0.0189
Schistosoma mansoni acetylcholine receptor-related 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0092 0.0553
Leishmania major hypothetical protein, conserved 0.0036 0.0084 0.0185
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0191 0.0189
Schistosoma mansoni single-minded 0.0049 0.0138 0.0137
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0084 0.1253
Schistosoma mansoni inositol monophosphatase 0.0036 0.0087 0.0086
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0191
Brugia malayi excitatory GABA receptor EXP-1A 0.0087 0.0285 0.0284
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0579 0.0578
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0087 0.0285 0.0284
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0092 0.0091
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0087 0.0285 0.0284
Brugia malayi phosphofructokinase 0.0109 0.037 0.0368
Schistosoma mansoni tyrosine kinase 0.0015 0.0005 0.0003
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0437 0.1652 0.1651
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Brugia malayi jmjC domain containing protein 0.0106 0.036 0.0359
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.004 0.0102 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0084 0.0185
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Brugia malayi sulfakinin receptor protein 0.0063 0.0191 0.0189
Brugia malayi PHD-finger family protein 0.0032 0.0072 0.0071
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0015 0.0107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.005 0.0049
Schistosoma mansoni nAChR subunit 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0102 0.0101
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0087 0.0285 0.0284
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0087 0.0189
Echinococcus multilocularis GPCR, family 2 0.0032 0.007 0.0069
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0049 0.01
Loa Loa (eye worm) beta-lactamase 0.0036 0.0084 0.0082
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0102 0.0101
Schistosoma mansoni amine GPCR 0.0063 0.0191 0.0189
Schistosoma mansoni biogenic amine receptor 0.0063 0.0191 0.0189
Echinococcus granulosus nAChR subunit 0.0087 0.0285 0.0284
Schistosoma mansoni nAChR subunit 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0015 0.002
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0092 0.0032
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.0191 0.0189
Echinococcus granulosus nAChR subunit 0.0047 0.0128 0.0127
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0285 0.0284
Brugia malayi hypothetical protein 0.004 0.0102 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0015 0.0107
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0233 0.0231
Loa Loa (eye worm) RecQ helicase 0.0021 0.0027 0.0026
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0233 0.0231
Schistosoma mansoni hypothetical protein 0.0069 0.0215 0.0214
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Schistosoma mansoni hypothetical protein 0.0032 0.007 0.0069
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0285 0.0284
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0099 0.0097
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0072 0.0805
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Schistosoma mansoni lipoxygenase 0.0082 0.0267 0.0266
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni glutamate receptor NMDA 0.0313 0.1166 0.1165
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0087 0.0192
Loa Loa (eye worm) serotonin transporter b 0.2576 1 1
Onchocerca volvulus 0.0063 0.0191 0.0189
Brugia malayi Cytochrome P450 family protein 0.0018 0.0015 0.0013
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0054 0.0158 0.0157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0191 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Loa Loa (eye worm) GABA receptor subunit 0.0047 0.0128 0.0127
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0203 0.0462
Leishmania major cytochrome p450-like protein 0.0027 0.0049 0.0103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0049 0.0048
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0203 0.0459
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Echinococcus granulosus allatostatin A receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0071
Giardia lamblia Fructose-bisphosphate aldolase 0.0326 0.1216 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0285 0.0284
Brugia malayi Melatonin receptor type 1A 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0569 0.2168 0.2167
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0087 0.0285 0.0284
Schistosoma mansoni hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.0191 0.0189
Trypanosoma brucei C-8 sterol isomerase, putative 0.1114 0.4294 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0203 0.1636
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0022 0.0021
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0203 0.0202
Loa Loa (eye worm) glutamate receptor 1 0.0147 0.052 0.0518
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0437 0.1652 0.1651
Schistosoma mansoni rab6-interacting 0.002 0.0022 0.0021
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0944
Echinococcus multilocularis vesicular acetylcholine transporter 0.0877 0.3369 0.3368
Brugia malayi hypothetical protein 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0032 0.007 0.0069
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0285 0.0284
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.036 0.0359
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0072 0.1044
Schistosoma mansoni polycystin 1-related 0.002 0.0022 0.0021
Onchocerca volvulus 0.0047 0.0128 0.0127
Brugia malayi AKH receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.004 0.0102 0.0101
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0094 0.0093
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Brugia malayi hypothetical protein 0.004 0.0102 0.0101
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0022 0.0099
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.037 0.2879
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0203 0.0202
Trypanosoma brucei C-14 sterol reductase, putative 0.0099 0.033 0.0756
Brugia malayi Protein kinase domain containing protein 0.0014 0.0001 0.0000000032544
Schistosoma mansoni glutamate receptor NMDA 0.0241 0.0887 0.0886
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni hypothetical protein 0.0032 0.0072 0.0071
Echinococcus granulosus metabotropic glutamate receptor 5 0.0015 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.0063 0.0191 0.0189
Brugia malayi neuropeptide F receptor 0.0063 0.0191 0.0189
Echinococcus granulosus hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.0191 0.0189
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0437 0.1652 0.1651
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.006 0.0274
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0203 0.0462
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0054 0.0158 0.0157
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.01 0.0099
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.0191 0.0189
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.037 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Loa Loa (eye worm) norepinephrine transporter 0.2576 1 1
Onchocerca volvulus 0.0063 0.0191 0.0189
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Brugia malayi hypothetical protein 0.0035 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0191 0.0189
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0015 0.0013
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0542 0.0541
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0005 0.0003
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0159 0.0566 0.0565
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0015 0.0107
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.0191 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0191
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0084 0.0082
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0191 0.0189
Brugia malayi Dopamine receptor protein 1 0.0063 0.0191 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0006 0.0003
Onchocerca volvulus 0.0036 0.0084 0.0082
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.0634
Echinococcus multilocularis glutamate receptor NMDA 0.0079 0.0253 0.0252
Schistosoma mansoni voltage-gated potassium channel 0.004 0.01 0.0099
Brugia malayi hypothetical protein 0.0166 0.0592 0.0591
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0084 0.0185
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0437 0.1652 1
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.0191 0.0189
Brugia malayi MH2 domain containing protein 0.0116 0.0397 0.0396
Brugia malayi vesicular acetylcholine transporter unc-17 0.0877 0.3369 0.3368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0579 0.0578
Echinococcus granulosus peregrin 0.0032 0.0072 0.0071
Onchocerca volvulus 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0191 0.0189
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Plasmodium falciparum phd finger protein, putative 0.0032 0.0072 0.0401
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.007 0.0069
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0313 0.1166 0.1165
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Toxoplasma gondii ABC1 family protein 0.0036 0.0084 0.0507
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Echinococcus multilocularis lamin dm0 0.0027 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni myosin xvIII 0.0063 0.0191 0.0189
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0437 0.1652 0.1651
Mycobacterium leprae Probable lipase LipE 0.0036 0.0084 0.1253
Schistosoma mansoni amine GPCR 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0015 0.0107
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0437 0.1652 0.1651
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0162 0.0579 0.0578
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Brugia malayi Cytochrome P450 family protein 0.0018 0.0015 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.037 0.2879
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0015 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0015 0.0107
Schistosoma mansoni glutamate receptor kainate 0.0147 0.052 0.0518
Onchocerca volvulus 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Brugia malayi Uncoordinated protein 44 0.0014 0.0001 0.0000000032544
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0162 0.0579 0.0578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0123 0.0121
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0006 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.034 0.0339
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Brugia malayi PAS domain containing protein 0.0049 0.0138 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0092 0.0545
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0005 0.0003
Schistosoma mansoni sodium/chloride dependent transporter 0.0437 0.1652 0.1651
Brugia malayi Cation transporter family protein 0.0087 0.0285 0.0284
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0191 0.0189
Schistosoma mansoni protein kinase 0.0015 0.0005 0.0003
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0162 0.0579 0.0578
Onchocerca volvulus 0.0063 0.0191 0.0189
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0081 0.008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0191
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.037 0.4408
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0944
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.0191 0.0189
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.0191 0.0189
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.0191 0.0189
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0565 0.215 0.2149
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.2554 0.9916 0.9916
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0054 0.0158 0.0157
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.0566 1
Onchocerca volvulus Alhambra homolog 0.0032 0.0072 0.0071
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.037 0.6435
Plasmodium falciparum amino acid transporter, putative 0.0437 0.1652 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0015 0.0107
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0102 0.0101
Brugia malayi larval opioid receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0015 0.0107
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0006 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0087 0.0528
Schistosoma mansoni neuropeptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0005 0.0003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0087 0.0192
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.0191 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0084 0.0476
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus granulosus single minded 2 0.004 0.0101 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0084 0.0476
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0081 0.008
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0087 0.0086
Schistosoma mansoni opsin-like receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0877 0.3369 0.3368
Loa Loa (eye worm) hypothetical protein 0.0069 0.0215 0.0214
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.037 0.3012
Onchocerca volvulus 0.0063 0.0191 0.0189
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.006 0.0274
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0084 0.0944
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.2598 0.2597
Onchocerca volvulus 0.0159 0.0566 0.0565
Plasmodium falciparum transporter, putative 0.0437 0.1652 1
Schistosoma mansoni hypothetical protein 0.0018 0.0015 0.0013
Onchocerca volvulus 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Treponema pallidum fructose-bisphosphate aldolase 0.0326 0.1216 0.1163
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0285 0.0284
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0015 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0215 0.0214
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0285 0.0284
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.0191 0.0189
Echinococcus multilocularis orexin receptor type 2 0.0063 0.0191 0.0189
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0015 0.0005 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0437 0.1652 1
Trypanosoma cruzi C-14 sterol reductase, putative 0.0099 0.033 0.0759
Schistosoma mansoni opsin-like receptor 0.0063 0.0191 0.0189
Brugia malayi Dopamine receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0044 0.0088
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.0128 0.0127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0092 0.0204
Echinococcus granulosus nmda type glutamate receptor 0.0133 0.0466 0.0464
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0101 0.034 0.0339
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0087 0.0285 0.0284
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0087 0.0285 0.0284
Echinococcus multilocularis sodium and chloride dependent glycine 0.0437 0.1652 0.1651
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.037 0.0851
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.005 0.0049
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0099 0.0097
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0192 0.0191
Schistosoma mansoni neuropeptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.0191 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0001 0.0000000032544
Loa Loa (eye worm) hypothetical protein 0.0047 0.0128 0.0127
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0094 0.0093
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0006 0.0005
Mycobacterium ulcerans beta-lactamase 0.0036 0.0084 0.1253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus granulosus nmda type glutamate receptor 0.0094 0.0313 0.0311
Brugia malayi beta-lactamase 0.0036 0.0084 0.0082
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.006 0.0362
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.112 0.4319 0.4318
Echinococcus multilocularis synaptic vesicular amine transporter 0.112 0.4319 0.4318
Schistosoma mansoni ATP-binding cassette transporter 0.0147 0.052 0.0518
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0015 0.0023
Brugia malayi neuropeptide F receptor 0.0063 0.0191 0.0189
Brugia malayi Cytochrome P450 family protein 0.0027 0.0049 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0009
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.004 0.0102 0.0101
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0005 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0099 0.0097
Brugia malayi follicle stimulating hormone receptor 0.0293 0.1089 0.1087
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.0191 0.0189
Brugia malayi Doublecortin family protein 0.002 0.0022 0.0021
Schistosoma mansoni sodium/chloride dependent transporter 0.2576 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Brugia malayi isocitrate dehydrogenase 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Onchocerca volvulus 0.004 0.0102 0.0101
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0088 0.0087
Echinococcus granulosus tyrosine kinase 0.0015 0.0005 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0099 0.0097
Loa Loa (eye worm) glutamate receptor 0.0015 0.0005 0.0003
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0005 0.0003
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.037 0.0368
Onchocerca volvulus 0.0015 0.0005 0.0003
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0437 0.1652 0.1651
Schistosoma mansoni hypothetical protein 0.0672 0.2567 0.2566
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.0191 0.0189
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0047 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Echinococcus multilocularis glutamate receptor 2 0.0147 0.052 0.0518
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Onchocerca volvulus 0.0437 0.1652 0.1651
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus glutamate receptor subunit protein glur 0.0054 0.0158 0.0157
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.037 0.0851
Echinococcus granulosus microtubule associated protein 2 0.0679 0.2598 0.2597
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Brugia malayi beta-lactamase family protein 0.0036 0.0084 0.0082
Onchocerca volvulus 0.004 0.0102 0.0101
Schistosoma mansoni glutamate receptor kainate 0.0147 0.052 0.0518
Brugia malayi RE15519p 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0015 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0122 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0022 0.0021
Brugia malayi jmjC domain containing protein 0.0039 0.0099 0.0097
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0437 0.1652 0.1651
Brugia malayi Cation transporter family protein 0.0087 0.0285 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0123 0.0121
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0092 0.0545
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.007 0.0069
Schistosoma mansoni glutamate receptor AMPA 0.0147 0.052 0.0518
Loa Loa (eye worm) solute carrier family 6 member 4 0.2576 1 1
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0437 0.1652 0.1651
Schistosoma mansoni opsin-like receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0191 0.0189
Schistosoma mansoni hypothetical protein 0.0054 0.0158 0.0157
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0877 0.3369 0.3368
Echinococcus multilocularis somatostatin receptor 0.0063 0.0191 0.0189
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0092 0.0278
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0087 0.0285 0.0284
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.037 0.0368
Loa Loa (eye worm) hypothetical protein 0.0159 0.0566 0.0565
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.2576 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0005
Schistosoma mansoni neuropeptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0027 0.005 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0072 0.0436
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0015 0.0023
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis geminin 0.0672 0.2567 0.2566
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0191 0.0189
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0084 0.0082
Brugia malayi G protein-coupled receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis musashi 0.0027 0.005 0.0049
Schistosoma mansoni sodium/chloride dependent transporter 0.0437 0.1652 0.1651
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0091
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0049 0.0103
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.0191 0.0189
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0122 0.012
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0092 0.1402
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0191 0.0189
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.006 0.0456
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0087 0.0681
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0831 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0082
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0087 0.0285 0.0284
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Brugia malayi Serotonin receptor 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0084 0.0944
Onchocerca volvulus 0.0159 0.0566 0.0565
Brugia malayi RNA binding protein 0.0063 0.0192 0.0191
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0285 0.0284
Schistosoma mansoni ap endonuclease 0.0038 0.0092 0.0091
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.0191 0.0189
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.036 0.0359
Brugia malayi hypothetical protein 0.0016 0.0009 0.0007
Echinococcus granulosus RUN 0.002 0.0022 0.0021
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0049 0.062
Schistosoma mansoni glutamate receptor kainate 0.0147 0.052 0.0518
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0005 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0092 0.0523
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Leishmania major cytochrome p450-like protein 0.0018 0.0015 0.0023
Onchocerca volvulus 0.002 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis peregrin 0.0032 0.0072 0.0071
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0027 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0123 0.0121
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0022 0.0021
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.0091
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0054 0.0158 0.0157
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0191 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0191 0.0189
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.0634
Onchocerca volvulus 0.0087 0.0285 0.0284
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0015 0.0005 0.0003
Onchocerca volvulus 0.0036 0.0084 0.0082
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.0634
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0138 0.0137
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0017 0.0069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0092 0.0091
Brugia malayi Glutamate receptor 2 precursor 0.0147 0.052 0.0518
Echinococcus granulosus glutamate receptor 2 0.0108 0.0367 0.0365
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0275 0.0274
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0437 0.1652 0.1651
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.006 0.0327
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.0191 0.0189
Schistosoma mansoni hypothetical protein 0.0032 0.007 0.0069
Echinococcus multilocularis lamin b receptor 0.0099 0.033 0.0329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.034 0.0339
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0191 0.0189
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0003
Echinococcus multilocularis nAChR subunit 0.0087 0.0285 0.0284
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0102 0.0101
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0092 0.0721
Brugia malayi hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Brugia malayi hypothetical protein 0.004 0.0102 0.0101
Onchocerca volvulus 0.0063 0.0191 0.0189
Echinococcus granulosus neuropeptide s receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0191 0.0189
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0092 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0123 0.0121
Loa Loa (eye worm) hypothetical protein 0.2576 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0084 0.0476
Echinococcus granulosus sodium and chloride dependent glycine 0.0437 0.1652 0.1651
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0087 0.0285 0.0284
Brugia malayi hypothetical protein 0.002 0.0022 0.0021
Schistosoma mansoni nAChR subunit 0.0087 0.0285 0.0284
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.0191 0.0189
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0285 0.0284
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0022 0.0021
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0005 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0123 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0084 0.0944
Schistosoma mansoni biogenic amine receptor 0.0063 0.0191 0.0189
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0006 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0285 0.0284
Echinococcus granulosus bloom syndrome protein 0.0021 0.0027 0.0026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0285 0.0284
Brugia malayi Cation transporter family protein 0.0159 0.0566 0.0565
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0005
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.037 0.6435
Schistosoma mansoni ap endonuclease 0.0038 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0191 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0015 0.0107
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0285 0.0284
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0285 0.0284
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2576 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.0087 0.0285 0.0284
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0191 0.0189
Loa Loa (eye worm) hypothetical protein 0.2576 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.0191 0.0189
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0285 0.0284
Onchocerca volvulus Neuropeptide F receptor homolog 0.0063 0.0191 0.0189
Onchocerca volvulus 0.0063 0.0191 0.0189
Echinococcus granulosus vesicular acetylcholine transporter 0.0877 0.3369 0.3368
Onchocerca volvulus 0.0027 0.005 0.0049
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.0191 0.0189
Echinococcus granulosus tar DNA binding protein 0.0063 0.0192 0.0191
Brugia malayi Inositol-1 0.0036 0.0087 0.0086
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0285 0.0284
Schistosoma mansoni adenoreceptor 0.0063 0.0191 0.0189
Brugia malayi 6-phosphofructokinase 0.0109 0.037 0.0368
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0189
Echinococcus multilocularis serotonin transporter 0.2576 1 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0192 0.0191
Toxoplasma gondii hypothetical protein 0.0437 0.1652 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0015 0.0107
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.0191 0.0189
Echinococcus granulosus geminin 0.0672 0.2567 0.2566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0326 0.1216 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis nAChR subunit 0.0047 0.0128 0.0127
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0088 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0192 0.0191
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0101
Brugia malayi Bromodomain containing protein 0.0032 0.0072 0.0071
Leishmania major C-8 sterol isomerase-like protein 0.1114 0.4294 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.0191 0.0189
Echinococcus granulosus somatostatin receptor 0.0063 0.0191 0.0189
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0087 0.0285 0.0284
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.006 0.0327
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0015 0.0107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0084 0.0082
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0015 0.0107
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0081 0.008

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) > 224 uM 50% inhibition of MT-4 cell proliferation. ChEMBL. 15214788
CD50 (functional) > 224 uM 50% inhibition of MT-4 cell proliferation. ChEMBL. 15214788
ID50 (functional) = 0.23 uM 50% inhibition of HIV replication in MT-4 cells ChEMBL. 15214788
ID50 (functional) = 0.23 uM 50% inhibition of HIV replication in MT-4 cells ChEMBL. 15214788
IS (functional) > 974 Ratio of CD50 to ID50 of the compound was determined ChEMBL. 15214788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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