Detailed information for compound 318795

Basic information

Technical information
  • TDR Targets ID: 318795
  • Name: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-meth ylindol-2-yl]-2,2-dimethylpropanoic acid
  • MW: 373.848 | Formula: C21H21ClFNO2
  • H donors: 1 H acceptors: 2 LogP: 5.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cn1c(CC(C(=O)O)(C)C)c(c2c1ccc(c2)F)C
  • InChi: 1S/C21H21ClFNO2/c1-13-17-10-16(23)8-9-18(17)24(12-14-4-6-15(22)7-5-14)19(13)11-21(2,3)20(25)26/h4-10H,11-12H2,1-3H3,(H,25,26)
  • InChiKey: JLPYLHLUHJOPNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methyl-indol-2-yl]-2,2-dimethyl-propanoic acid
  • 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methyl-2-indolyl]-2,2-dimethylpropanoic acid
  • 3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]-2,2-dimethyl-propionic acid
  • L 655240
  • 103253-15-2
  • Tocris-1698
  • Lopac0_000670
  • EU-0100670
  • 3-(1-(4-Chlorobenzyl)-5-fluoro-3-methylindol-2-yl)-2,2-dimethylpropanoic acid
  • NCGC00025263-01
  • 3-[1-(4-Chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]-2,2-dimethyl propanoic acid
  • L-655,240
  • L9539_SIGMA
  • Lopac-L-9539
  • NCGC00015618-01
  • 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-5-fluoro-alpha,alpha,3-trimethyl-
  • L-655240

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens prostaglandin E synthase 2 Starlite/ChEMBL References
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_130341 All targets in OG5_130341
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Trypanosoma congolense glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma brucei Prostaglandin E synthase Get druggable targets OG5_130341 All targets in OG5_130341
Leishmania donovani glutathione-S-transferase/glutaredoxin,putative Get druggable targets OG5_130341 All targets in OG5_130341
Neospora caninum hypothetical protein Get druggable targets OG5_130341 All targets in OG5_130341
Toxoplasma gondii prostaglandin-E synthase Get druggable targets OG5_130341 All targets in OG5_130341
Leishmania braziliensis glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130341 All targets in OG5_130341
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Onchocerca volvulus Get druggable targets OG5_130341 All targets in OG5_130341
Leishmania infantum glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Leishmania mexicana glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Trypanosoma brucei gambiense glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma cruzi glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Trypanosoma cruzi glutathione-S-transferase/glutaredoxin, putative Get druggable targets OG5_130341 All targets in OG5_130341
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0013 0.0014 0.0013
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0014 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0004
Brugia malayi follicle stimulating hormone receptor 0.028 0.0775 0.0773
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0633 0.0633
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0111 0.0109
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0055 0.0053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1739 0.4936 0.4935
Onchocerca volvulus 0.003 0.0062 0.0896
Brugia malayi CXXC zinc finger family protein 0.0028 0.0057 0.0055
Schistosoma mansoni carbonic anhydrase 0.217 0.6165 0.6165
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0013 0.0014 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0013 0.0014 0.0021
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0067 0.0094
Mycobacterium ulcerans hypothetical protein 0.0035 0.0077 0.0108
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.142 0.4025 1
Onchocerca volvulus 0.0163 0.0441 0.6904
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0005 0.0005
Plasmodium falciparum glutathione reductase 0.0037 0.0083 0.0165
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0354 0.0354
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0021 0.0021
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0013 0.0014 0.0013
Echinococcus granulosus glutamate synthase 0.001 0.0005 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0292 0.0714
Brugia malayi glutathione reductase 0.0107 0.0283 0.0282
Wolbachia endosymbiont of Brugia malayi carbonic anhydrase 0.0039 0.0089 0.5017
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0145 0.0145
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0292 0.0714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0101 0.0101
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0005 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0005
Schistosoma mansoni sulfide quinone reductase 0.001 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0089 0.0084
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0067 0.0133
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0021 0.0015
Plasmodium vivax SET domain protein, putative 0.003 0.0062 0.2029
Loa Loa (eye worm) glutathione reductase 0.0107 0.0283 0.0282
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0061
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0036 0.0047
Leishmania major protein kinase, putative 0.0015 0.0021 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0005 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0005 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0039 0.0089 0.0084
Leishmania major hypothetical protein, conserved 0.0035 0.0077 0.0072
Echinococcus multilocularis thioredoxin glutathione reductase 0.0107 0.0283 0.0283
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0636 0.0953
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0615 0.1517
Brugia malayi beta-lactamase family protein 0.0035 0.0077 0.0075
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0021 0.0015
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1739 0.4936 0.4935
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0078
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0354 0.0354
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0004
Trypanosoma brucei Prostaglandin E synthase 0.0163 0.0441 0.0436
Echinococcus multilocularis carbonic anhydrase 0.1739 0.4936 0.4936
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0077 0.0178
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0067 0.0133
Onchocerca volvulus 0.0028 0.0057 0.0819
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0029 0.0056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0078
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0083 0.0118
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0083 0.0078
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0061
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0036 0.0036
Echinococcus granulosus single minded 2 0.0043 0.0101 0.0101
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0009 0.0003
Loa Loa (eye worm) cytochrome P450 0.0013 0.0014 0.0012
Plasmodium falciparum glutathione reductase 0.0107 0.0283 0.0571
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0083 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0009 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0083 0.0118
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0077 0.0108
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0005 0.0004
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0062 0.0062
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0083 0.0194
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0004
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0013 0.0014 0.0021
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0077 0.0178
Onchocerca volvulus 0.0199 0.0544 0.8537
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0013 0.0014 0.0021
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0229 0.0632 0.1558
Echinococcus granulosus dynactin 5 p25 0.0068 0.0172 0.0172
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0077 0.0108
Brugia malayi Cytochrome P450 family protein 0.0013 0.0014 0.0012
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0066 0.0165 0.0241
Loa Loa (eye worm) hypothetical protein 0.0197 0.0539 0.0538
Entamoeba histolytica carbonic anhydrase, putative 0.217 0.6165 1
Schistosoma mansoni hypothetical protein 0.0047 0.0111 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0013 0.0014 0.0021
Schistosoma mansoni carbonic anhydrase 0.1739 0.4936 0.4936
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0023
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0021 0.0023
Schistosoma mansoni survival motor neuron protein 0.0047 0.0111 0.0111
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.001 0.0005 0.0004
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1112 0.1112
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0083
Brugia malayi Cytochrome P450 family protein 0.0059 0.0145 0.0144
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0013 0.0014 0.0013
Plasmodium falciparum thioredoxin reductase 0.0037 0.0083 0.0165
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.001 0.0005 0.0004
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0014 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0077 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0013 0.0014 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0005 0.0004
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1739 0.4936 0.4935
Brugia malayi Pre-SET motif family protein 0.003 0.0062 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Treponema pallidum NADH oxidase 0.0037 0.0083 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.037 0.0908
Plasmodium falciparum ferrodoxin reductase-like protein 0.001 0.0005 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0036 0.0035
Echinococcus multilocularis geminin 0.0165 0.0447 0.0447
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0013 0.0014 0.0013
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.3515 1 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0067 0.0062
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0013 0.0014 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Plasmodium vivax thioredoxin reductase, putative 0.0107 0.0283 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0021 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0775 0.0773
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0005 0.0005
Brugia malayi glutamate synthase 0.001 0.0005 0.0004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0005 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.037 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0057 0.0055
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0005 0.0004
Mycobacterium leprae Possible regulatory protein 0.0015 0.0021 0.0025
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0024 0.0024
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0021 0.0023
Loa Loa (eye worm) carbonic anhydrase 3 0.3515 1 1
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0068 0.0172 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0077 0.0072
Schistosoma mansoni single-minded 0.0059 0.0145 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Onchocerca volvulus 0.0047 0.0111 0.1677
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0013 0.0014 0.0013
Mycobacterium ulcerans transferase 0.0066 0.0165 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0014 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0062 0.0062
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0021 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0077 0.0108
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0083 0.0078
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0005 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0017 0.0427
Chlamydia trachomatis sulfate transporter 0.0032 0.0067 0.7971
Echinococcus granulosus FTZ F1 alpha 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0013 0.0014 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0083 0.2803
Schistosoma mansoni cpg binding protein 0.0028 0.0057 0.0057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0062 0.0062
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0005
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1739 0.4936 0.4935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0062 0.0062
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1141 0.323 0.8021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.000000000022553
Trypanosoma brucei trypanothione reductase 0.0107 0.0283 0.0278
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0083 0.4667
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0089 0.0084
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0021 0.0023
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0014 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0077 0.0077
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0083 0.0165
Mycobacterium tuberculosis Conserved protein 0.0035 0.0077 0.0178
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Toxoplasma gondii hypothetical protein 0.1739 0.4936 1
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.1259 0.3567 0.8859
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0101 0.01
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0083
Schistosoma mansoni DNA helicase recq5 0.0009 0.0002 0.0002
Mycobacterium ulcerans beta-lactamase 0.0035 0.0077 0.0108
Schistosoma mansoni hypothetical protein 0.0165 0.0447 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0004
Schistosoma mansoni cytochrome P450 0.0013 0.0014 0.0014
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0037 0.0083 0.4667
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0013 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0107 0.0283 0.0691
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0021 0.0015
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0083 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0077 0.0072
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0005 0.0005
Giardia lamblia Glutamate synthase 0.001 0.0005 0.0455
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0077 0.0077
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0005 0.0005
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.001 0.0005 0.0455
Echinococcus granulosus geminin 0.0165 0.0447 0.0447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0083 0.0078
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0013 0.0014 0.0021
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.3515 1 1
Plasmodium vivax glutathione reductase, putative 0.0107 0.0283 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.023 0.0633 0.0632
Echinococcus multilocularis cpg binding protein 0.003 0.0061 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0013 0.0014 0.0021
Giardia lamblia Thioredoxin reductase 0.001 0.0005 0.0455
Leishmania major cytochrome p450-like protein 0.0013 0.0014 0.0008
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.3515 1 1
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0014 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0062 0.0062
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.217 0.6165 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0013 0.0014 0.0021
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0101 0.0145
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0067 0.0062
Mycobacterium ulcerans hypothetical protein 0.0039 0.0089 0.0127
Onchocerca volvulus 0.0035 0.0077 0.1139
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0014 0.0012
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0013 0.0014 0.0021
Brugia malayi hypothetical protein 0.0197 0.0539 0.0538
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0013 0.0014 0.0013
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.001 0.0005 0.0008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0077 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0077 0.0178
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0021 0.0015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Leishmania major carbonic anhydrase family protein, putative 0.217 0.6165 0.6163
Schistosoma mansoni glutamate synthase 0.001 0.0005 0.0005
Plasmodium falciparum thioredoxin reductase 0.0107 0.0283 0.0571
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0005 0.0004
Loa Loa (eye worm) histone methyltransferase 0.001 0.0005 0.0003
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1739 0.4936 0.4935
Trypanosoma cruzi glutathione-S-transferase/glutaredoxin, putative 0.0163 0.0441 0.0436
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.001 0.0005 0.0008
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0292 0.0714
Echinococcus multilocularis carbonic anhydrase 0.1739 0.4936 0.4936
Leishmania major protein kinase, putative 0.0015 0.0021 0.0015
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0013 0.0014 0.0013
Loa Loa (eye worm) RecQ helicase 0.0021 0.0036 0.0035
Onchocerca volvulus 0.0035 0.0077 0.1139
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0013 0.0014 0.0021
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0083
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0077 0.0178
Loa Loa (eye worm) hypothetical protein 0.3465 0.9859 0.9859
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0005 0.0004
Entamoeba histolytica ankyrin, putative 0.0068 0.0172 0.0271
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0292 0.0714
Mycobacterium leprae PROBABLE TRANSFERASE 0.0066 0.0165 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0089 0.0084
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0005 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0107 0.0283 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0107 0.0283 0.0282
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0021 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0077 0.0108
Entamoeba histolytica acetyltransferase, putative 0.0068 0.0172 0.0271
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0037 0.0083 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0021 0.0015
Onchocerca volvulus 0.0035 0.0077 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0004
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0013 0.0014 0.0013
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0292 0.0714
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0002 0.0002
Mycobacterium leprae Conserved hypothetical protein 0.0013 0.0014 0.0014
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.001 0.0005 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0014 0.0012
Echinococcus granulosus carbonic anhydrase 0.1739 0.4936 0.4936
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0496 0.0494
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0005 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0004
Brugia malayi PAS domain containing protein 0.0059 0.0145 0.0143
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0083 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0023
Schistosoma mansoni carbonic anhydrase-related 0.1739 0.4936 0.4936
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0014 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0145 0.0144
Onchocerca volvulus 0.0066 0.0165 0.253
Brugia malayi hypothetical protein 0.023 0.0633 0.0632
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0005
Mycobacterium ulcerans carbonic anhydrase 0.2331 0.6624 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0002 0.0002
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.3515 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0077 0.0108
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0021 0.1975
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0013 0.0014 0.0021
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0067 0.0094
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.3515 1 1
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0039 0.0089 0.0208
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0021 0.0023
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0326 0.0326
Brugia malayi hypothetical protein 0.0163 0.0441 0.0439
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0083 0.0078
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0013 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0165 0.0447 0.0447
Mycobacterium leprae putative cytochrome p450 0.0013 0.0014 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0077 0.0116
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0014 0.0008
Schistosoma mansoni sulfide quinone reductase 0.001 0.0005 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0083 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0077 0.0077
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1739 0.4936 0.4935
Mycobacterium leprae Probable lipase LipE 0.0035 0.0077 0.0116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0005
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0013 0.0014 0.0013
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0083 0.0082
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0077 0.0075
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0556 0.0555
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0013 0.0014 0.0021
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0005 0.0005
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0067 0.0062
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0009 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0077 0.2581
Toxoplasma gondii ABC1 family protein 0.0035 0.0077 0.0153
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0014 0.0008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.037 0.0593
Schistosoma mansoni carbonic anhydrase-related 0.1739 0.4936 0.4936
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0021 0.0023
Brugia malayi Cytochrome P450 family protein 0.0013 0.0014 0.0012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0077 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0075
Schistosoma mansoni hypothetical protein 0.0398 0.1112 0.1112
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0083 0.0165
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0013 0.0014 0.0013
Onchocerca volvulus Putative sulfate transporter 0.0199 0.0544 0.8537
Loa Loa (eye worm) beta-lactamase 0.0035 0.0077 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0165 0.0241
Onchocerca volvulus 0.0231 0.0636 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0163 0.0441 0.0439
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0002 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0077 0.0108
Brugia malayi beta-lactamase family protein 0.0035 0.0077 0.0075
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0057 0.0057
Trichomonas vaginalis esterase, putative 0.0035 0.0077 0.0108
Onchocerca volvulus 0.0043 0.0101 0.1521
Loa Loa (eye worm) programmed cell death 8 0.001 0.0005 0.0004
Trypanosoma brucei carbonic anhydrase-like protein 0.3515 1 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0009 0.0003
Schistosoma mansoni hypothetical protein 0.0122 0.0326 0.0326
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0009 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0005
Schistosoma mansoni glutamate synthase 0.001 0.0005 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.1739 0.4936 0.4935
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1112 0.1112
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0021 0.0023
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0077 0.0178
Schistosoma mansoni glutamate synthase 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0004
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0068 0.0172 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0013 0.0014 0.0013
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0036 0.0047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0062 0.0122
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0013 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.1739 0.4936 0.4935
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.001 0.0005 0.0008
Brugia malayi cytochrome P450 0.0013 0.0014 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0013 0.0014 0.0021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0005
Brugia malayi Pre-SET motif family protein 0.0203 0.0556 0.0555
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0013 0.0014 0.0013
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0633 0.0633
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0005 0.0005
Echinococcus granulosus carbonic anhydrase 0.1739 0.4936 0.4936
Echinococcus granulosus thioredoxin glutathione reductase 0.0107 0.0283 0.0283
Echinococcus granulosus bloom syndrome protein 0.0021 0.0036 0.0036
Schistosoma mansoni DNA helicase recq1 0.0009 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0021 0.0021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0083 0.0078
Mycobacterium ulcerans lipase LipD 0.0035 0.0077 0.0108
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.037 0.0908
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0017 0.0031
Brugia malayi beta-lactamase 0.0035 0.0077 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Schistosoma mansoni carbonic anhydrase-related 0.1739 0.4936 0.4936
Echinococcus multilocularis carbonic anhydrase II 0.3515 1 1
Brugia malayi Thioredoxin reductase 0.0107 0.0283 0.0282
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0077 0.0178
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0083 0.0165
Mycobacterium ulcerans carbonic anhydrase 0.217 0.6165 0.9307
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.001 0.0005 0.0004
Onchocerca volvulus 0.001 0.0005 0.0002
Leishmania major cytochrome p450-like protein 0.0013 0.0014 0.0008
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0014 0.0008
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0067 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0013 0.0014 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0005
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0005 0.0005
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0005 0.0005
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0021 0.0015
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0013 0.0014 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.1739 0.4936 0.4936
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0005 0.0005
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0021 0.0019
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0013 0.0014 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0005
Brugia malayi Putative carbonic anhydrase 5 precursor 0.3515 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0077 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0083 0.0078
Schistosoma mansoni hypothetical protein 0.0013 0.0014 0.0014
Plasmodium falciparum carbonic anhydrase 0.1739 0.4936 1
Onchocerca volvulus 0.0015 0.0021 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0013 0.0014 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.006
Plasmodium vivax sulfate transporter, putative 0.0032 0.0067 0.2235
Echinococcus granulosus carbonic anhydrase 0.1739 0.4936 0.4936
Trypanosoma cruzi glutathione-S-transferase/glutaredoxin, putative 0.0163 0.0441 0.0436
Mycobacterium leprae Probable transmembrane transport protein 0.0229 0.0632 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.2331 0.6624 1
Echinococcus multilocularis carbonic anhydrase 0.1739 0.4936 0.4936
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0013 0.0014 0.0013
Toxoplasma gondii selenide, water dikinase 0.001 0.0005 0.0008
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0005 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0083 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0354 0.0354
Toxoplasma gondii prostaglandin-E synthase 0.0163 0.0441 0.089
Leishmania major glutathione-S-transferase/glutaredoxin, putative 0.0163 0.0441 0.0436
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0014 0.0008
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0005 0.0005
Echinococcus granulosus carbonic anhydrase II 0.3515 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0004
Leishmania major cytochrome p450-like protein 0.0013 0.0014 0.0008
Mycobacterium tuberculosis Probable reductase 0.0111 0.0292 0.0714
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0326 0.0326
Toxoplasma gondii thioredoxin reductase 0.0107 0.0283 0.0571
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0083 0.0165
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0083 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0021 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0013 0.0014 0.0021
Echinococcus multilocularis 0.0013 0.0014 0.0014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0055 0.0053
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0083 0.0078
Leishmania major trypanothione reductase 0.0107 0.0283 0.0278
Echinococcus granulosus cpg binding protein 0.003 0.0061 0.0061
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0292 0.0466
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.001 0.0005 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.2331 0.6624 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0131 0.0263
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0077 0.0108
Brugia malayi ecdysteroid receptor 0.001 0.0005 0.0004
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0013 0.0014 0.0013
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0068 0.0172 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0013 0.0014 0.0021
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0013 0.0014 0.0013
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0039 0.0089 0.0136
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0005 0.0005
Leishmania major carbonic anhydrase-like protein 0.3515 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.001 0.0005 0.0005
Echinococcus multilocularis glutamate synthase 0.001 0.0005 0.0005
Brugia malayi hypoxia-induced factor 1 0.0182 0.0496 0.0494

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (binding) = 2.6 uM Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) ChEMBL. 15953724
IC50 (binding) = 2.6 uM Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1) ChEMBL. 15953724
Potency (ADMET) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.