Detailed information for compound 332128

Basic information

Technical information
  • TDR Targets ID: 332128
  • Name: 2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N,N -diethylimidazole-4-carboxamide
  • MW: 422.735 | Formula: C20H18Cl3N3O
  • H donors: 0 H acceptors: 2 LogP: 5.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)c1cn(c(n1)c1ccc(cc1)Cl)c1ccc(cc1Cl)Cl)CC
  • InChi: 1S/C20H18Cl3N3O/c1-3-25(4-2)20(27)17-12-26(18-10-9-15(22)11-16(18)23)19(24-17)13-5-7-14(21)8-6-13/h5-12H,3-4H2,1-2H3
  • InChiKey: WWDOVXBGLHLBKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N,N-diethyl-imidazole-4-carboxamide
  • 2-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N,N-diethyl-4-imidazolecarboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein gamma-aminobutyric acid (GABA) A receptor, alpha 2 451 aa 393 aa 25.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0008 0.0003 0.0036
Schistosoma mansoni coup transcription factor 0.0021 0.0032 0.0099
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0084 0.0227
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0718
Entamoeba histolytica histone deacetylase, putative 0.0269 0.0592 1
Brugia malayi phosphofructokinase 0.011 0.0234 0.3159
Schistosoma mansoni rotamase 0.0034 0.0063 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0042 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0107 0.0097
Schistosoma mansoni DNA helicase recq1 0.002 0.0031 0.0095
Brugia malayi MH2 domain containing protein 0.0008 0.0004 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0032 0.0419
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.003 0.0493
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0032 0.0084
Mycobacterium ulcerans hypothetical protein 0.0072 0.0148 0.0138
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0092
Giardia lamblia Histone deacetylase 0.0269 0.0592 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0077 0.0067
Onchocerca volvulus 0.0012 0.0012 0.0219
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0066 0.0176
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0019 0.0263
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.0019 0.0263
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0067
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0007 0.0086
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0006 0.0074
Onchocerca volvulus 0.0072 0.0148 0.2796
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.0393 0.5637
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0009 0.0006 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0178 0.2914
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0148 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.0444
Brugia malayi glutaminase DH11.1 0.0277 0.061 0.8267
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.002
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.0914 0.2482
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Treponema pallidum DNA ligase (lig) 0.002 0.003 0.0269
Trypanosoma cruzi histone deacetylase, putative 0.0133 0.0285 0.4083
Brugia malayi Carboxylesterase family protein 0.0065 0.0133 0.179
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.001 0.0128
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0211 0.3023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.0074
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0031 0.0402
Onchocerca volvulus 0.0008 0.0003 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.029
Loa Loa (eye worm) hypothetical protein 0.0084 0.0174 0.2495
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0033 0.0467
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0032 0.0099
Trypanosoma cruzi histone deacetylase 1, putative 0.0269 0.0592 0.8495
Loa Loa (eye worm) hypothetical protein 0.0103 0.0218 0.3119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0067
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0031 0.0095
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0009 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0086
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0033 0.0023
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0009
Mycobacterium ulcerans oxidoreductase 0.0041 0.0077 0.0067
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0236 0.0516 0.1047
Brugia malayi Myosin head containing protein 0.0012 0.0012 0.0157
Schistosoma mansoni acetylcholinesterase 0.0011 0.001 0.003
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0033 0.0023
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0052 0.0046
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0009 0.0006 0.0096
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0036 0.0516
Schistosoma mansoni hypothetical protein 0.0412 0.0914 0.2919
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0174 0.0555
Trypanosoma cruzi histone deacetylase, putative 0.0133 0.0285 0.4083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.01 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0426
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0009 0.0006 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0128
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0004 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0107
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0008 0.0003 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus granulosus importin subunit beta 1 0.0029 0.0051 0.0159
Loa Loa (eye worm) GABA receptor subunit 0.0008 0.0003 0.0038
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0165 0.0357 0.1138
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Echinococcus granulosus acetylcholinesterase 0.0065 0.0133 0.0422
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0021 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0123 0.176
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0009 0.0006 0.0041
Brugia malayi nuclear receptor NHR-88 0.0021 0.0032 0.0419
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.0019 0.0263
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0021 0.0295
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.01 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0033 0.0437
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0033 0.0088
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0316 0.1009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Onchocerca volvulus 0.0014 0.0017 0.0299
Entamoeba histolytica Ran family GTPase 0.0021 0.0033 0.0509
Onchocerca volvulus 0.0021 0.0033 0.0611
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0036 0.0513
Trichomonas vaginalis ran, putative 0.0021 0.0033 0.0548
Onchocerca volvulus 0.0012 0.0012 0.0219
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0036 0.0513
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.164 0.368 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0033 0.0503
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0627
Brugia malayi Patched related family protein 12 0.0012 0.0012 0.0157
Onchocerca volvulus 0.001 0.0007 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.003 0.0424
Onchocerca volvulus 0.0241 0.0528 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0061 0.0975
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0099
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0165 0.0357 0.1138
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0069 0.1134
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.0036 0.0513
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0033 0.0028
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0033 0.0023
Plasmodium falciparum flap endonuclease 1 0.0026 0.0044 0.0038
Echinococcus granulosus histone deacetylase 6 0.0322 0.071 0.2268
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0211 0.0201
Echinococcus multilocularis nAChR subunit 0.0008 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.1526
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.1526
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.0019 0.0058
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0986
Trichomonas vaginalis rotamase, putative 0.0034 0.0061 0.0998
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0174 0.0472
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0128
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0044 0.0657
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0326 0.4667
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0226
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0133 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0097 0.1387
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0419
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0084 0.0267
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0038 0.0628
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0008 0.0003 0.0036
Brugia malayi Protein kinase domain containing protein 0.0181 0.0393 0.5321
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0084 0.1204
Schistosoma mansoni jumonji domain containing protein 0.006 0.012 0.038
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0061 0.0055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0019 0.0058
Brugia malayi hypothetical protein 0.0122 0.0261 0.3528
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0077 0.1028
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.0019 0.0263
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0269 0.0592 0.8494
Loa Loa (eye worm) hypothetical protein 0.0153 0.0331 0.4739
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0009 0.0006 0.0096
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0025 0.0076
Onchocerca volvulus 0.0014 0.0017 0.0299
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0069 0.0186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0077 0.0071
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0083 0.0261
Brugia malayi ecdysone receptor 0.001 0.0007 0.0086
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0009 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0081 0.1155
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0442
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0127 0.0402
Echinococcus granulosus defective proboscis extension response 0.0016 0.002 0.0062
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0007 0.0021
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0605 0.1349 0.2695
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus dnaJ subfamily B 0.0412 0.0914 0.2919
Brugia malayi hypothetical protein 0.002 0.003 0.0396
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0021 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0173
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0042 0.06
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0033 0.0437
Plasmodium falciparum histone deacetylase 2 0.0316 0.0697 0.0691
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0181 0.0393 0.5635
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0031 0.0426
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0055 0.0049
Plasmodium falciparum protein kinase 5 0.0044 0.0084 0.0079
Echinococcus multilocularis dna polymerase kappa 0.01 0.0211 0.0571
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0274
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0006 0.0068
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0069 0.0218
Schistosoma mansoni Smad4 0.0008 0.0004 0.0009
Trypanosoma brucei histone deacetylase 4 0.0316 0.0697 1
Echinococcus multilocularis histone deacetylase 0.0316 0.0697 0.1891
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0063 0.1028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0099
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Onchocerca volvulus 0.001 0.0007 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0148 0.0138
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0019 0.0058
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0605 0.1349 0.134
Leishmania major histone deacetylase, putative 0.0316 0.0697 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0033 0.0023
Schistosoma mansoni patched 1 0.0085 0.0178 0.0565
Echinococcus multilocularis bloom syndrome protein 0.002 0.0031 0.0081
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.0434 0.1384
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0032 0.0099
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0073 0.015 0.0478
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus granulosus histone deacetylase 7 0.0316 0.0697 0.2224
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0127 0.0402
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0084
Brugia malayi hypothetical protein 0.0011 0.001 0.0126
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.001 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0393 0.1253
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0033 0.0027
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0084 0.1204
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.001 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0148 0.0138
Schistosoma mansoni terminal deoxycytidyl transferase 0.0073 0.015 0.0478
Leishmania major hypothetical protein, conserved 0.0025 0.0042 0.0602
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0628
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0032 0.0586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.037 0.0818 0.079
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Echinococcus granulosus smad 0.0008 0.0004 0.0009
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0123 0.0392
Chlamydia trachomatis dehyroquinate synthase 0.0236 0.0516 0.0487
Echinococcus granulosus tar DNA binding protein 0.0063 0.0127 0.0402
Schistosoma mansoni hypothetical protein 0.0245 0.0537 0.1714
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0107 0.0101
Mycobacterium ulcerans DNA polymerase IV 0.01 0.0211 0.0201
Schistosoma mansoni hypothetical protein 0.0048 0.0093 0.0294
Loa Loa (eye worm) hypothetical protein 0.018 0.039 0.559
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Schistosoma mansoni cpg binding protein 0.0031 0.0054 0.017
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0119 0.0114
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.001 0.002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0033 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0419
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0028 0.0381
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.0019 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0462 0.6632
Onchocerca volvulus 0.0029 0.005 0.094
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0075 0.1171
Brugia malayi polk-prov protein 0.005 0.0097 0.1308
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0093 0.0294
Schistosoma mansoni ran 0.0021 0.0033 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.0397
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.0019 0.0248
Entamoeba histolytica hypothetical protein 0.002 0.003 0.0452
Mycobacterium ulcerans glutaminase 0.0277 0.061 0.06
Loa Loa (eye worm) carboxylesterase 0.0011 0.001 0.0133
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0031 0.0081
Echinococcus granulosus histone deacetylase 8 0.0133 0.0285 0.0908
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0023 0.0306
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0069 0.1134
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.1526
Loa Loa (eye worm) hypothetical protein 0.0072 0.0148 0.2118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus multilocularis Immunoglobulin 0.0016 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.003 0.0424
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0017 0.0011
Brugia malayi TAR-binding protein 0.0063 0.0127 0.1708
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0199 0.0434 0.6223
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.001 0.0025
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0067
Echinococcus multilocularis expressed protein 0.0034 0.0063 0.0168
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0016 0.002 0.0062
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0174 0.0555
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.0019 0.0058
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0021 0.0065
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0219
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0598
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0234 0.0224
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0006 0.0074
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0984
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.0165 0.2368
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0009 0.0118
Echinococcus granulosus histone deacetylase 6 0.0316 0.0697 0.2224
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0234 0.383
Echinococcus granulosus GPCR family 2 0.0048 0.0093 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0493
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.01 0.0211 0.3461
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0629
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Plasmodium falciparum chorismate synthase 0.4445 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0009 0.0006 0.0077
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0042 0.0081 0.0075
Toxoplasma gondii histone deacetylase HDAC4 0.0133 0.0285 0.0279
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0021 0.0055
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0031 0.0025
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.001 0.003
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0084 0.0227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0093 0.025
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0015 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0122 0.0261 0.3736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0326 0.4407
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0073 0.015 0.0406
Onchocerca volvulus 0.0015 0.0019 0.0347
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0033 0.0067
Echinococcus multilocularis Smad4 0.0008 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Brugia malayi histone deacetylase 11 0.0133 0.0285 0.3854
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0009 0.0006 0.0096
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.002
Brugia malayi MH1 domain containing protein 0.0008 0.0004 0.004
Echinococcus granulosus Smad4 0.0008 0.0004 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0218 0.2945
Toxoplasma gondii histone deacetylase HDAC5 0.0133 0.0285 0.0279
Brugia malayi cell division control protein 2 homolog 0.0044 0.0084 0.1133
Trypanosoma cruzi histone deacetylase, putative 0.0316 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0007 0.0002
Onchocerca volvulus 0.002 0.003 0.0554
Loa Loa (eye worm) histone methyltransferase 0.001 0.0008 0.0101
Brugia malayi hypothetical protein 0.0011 0.001 0.0121
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0019 0.0058
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0023 0.0324
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0127 0.1708
Loa Loa (eye worm) hypothetical protein 0.0098 0.0207 0.2957
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0083 0.1355
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0066 0.0207
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0042 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0114 0.163
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0083 0.0077
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.0019 0.0263
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.0032
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0393
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0033 0.0467
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0307 0.0979
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0077 0.0095
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0084 0.1383
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0234 0.383
Echinococcus multilocularis nAChR subunit 0.0015 0.0019 0.005
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.003 0.0263
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.001 0.003
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Onchocerca volvulus 0.0021 0.0033 0.0611
Echinococcus granulosus nibrin 0.002 0.003 0.0093
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0021 0.0292
Brugia malayi Cation transporter family protein 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0019 0.0058
Entamoeba histolytica protein kinase, putative 0.0181 0.0393 0.6619
Loa Loa (eye worm) hypothetical protein 0.0048 0.0093 0.1323
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0084
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0245 0.0537 0.1714
Schistosoma mansoni nephrin 0.0016 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0133 0.0285 0.4081
Brugia malayi hypothetical protein 0.0025 0.0042 0.0565
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0219
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0033 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.0444
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0234 0.3912
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.01 0.0203
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0087
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0031 0.0402
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.0165 0.0335
Plasmodium vivax JmjC domain containing protein 0.0016 0.0021 0.0015
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0033 0.0103
Brugia malayi Cation transporter family protein 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0105 0.0221 0.3164
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.002
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0019 0.005
Brugia malayi Protein kinase domain containing protein 0.0044 0.0084 0.1133
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0031 0.05
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0066 0.0207
Loa Loa (eye worm) hypothetical protein 0.0189 0.0411 0.5894
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0055 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0148 0.0241
Schistosoma mansoni cell adhesion molecule 0.0016 0.002 0.0062
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0269 0.0592 0.9703
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0093 0.0294
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus multilocularis histone deacetylase 3 0.0269 0.0592 0.1606
Entamoeba histolytica deoxycytidyl transferase, putative 0.0073 0.015 0.2496
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0033 0.0467
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0051 0.016
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0122 0.026 0.0827
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0165 0.0357 0.0968
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0044 0.0038
Trypanosoma cruzi histone deacetylase, putative 0.0316 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0128
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0212 0.0676
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0019 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0007 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0033 0.0437
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0019 0.005
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0274
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0127 0.1809
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0033 0.0465
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.037 0.0818 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0126 0.04
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Brugia malayi hypothetical protein 0.0012 0.0012 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.0211 0.3023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0093 0.025
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Onchocerca volvulus 0.0011 0.001 0.0176
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0231 0.0506 0.1373
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0174 0.0555
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.0036 0.0513
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.0019 0.0058
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0107 0.0101
Loa Loa (eye worm) phosphofructokinase 0.011 0.0234 0.3346
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.2192 0.4924 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0031 0.042
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0031 0.0402
Mycobacterium ulcerans dehydrogenase 0.0041 0.0077 0.0067
Brugia malayi Patched related family protein 10 0.0012 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni gliotactin 0.0011 0.001 0.003
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.0462
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.0019 0.0248
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0033 0.0437
Entamoeba histolytica hypothetical protein 0.0036 0.0066 0.1055
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0033 0.0027
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0063 0.0889
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0069 0.1117
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0052 0.0046
Brugia malayi hypothetical protein 0.0012 0.0012 0.0157
Brugia malayi Patched protein homolog 1 0.0012 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0087
Brugia malayi 6-phosphofructokinase 0.011 0.0234 0.3161
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0007 0.012
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0334 0.0738 1
Brugia malayi DKFZp564C0469 protein 0.002 0.003 0.0396
Echinococcus granulosus replication factor c subunit 1 0.002 0.003 0.0093
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0148 0.2122
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.0397
Onchocerca volvulus 0.0015 0.0019 0.0347
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0468
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0077 0.0206
Brugia malayi jmjC domain containing protein 0.006 0.012 0.1612
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.005
Plasmodium falciparum histone deacetylase, putative 0.0316 0.0697 0.0691
Echinococcus granulosus histone deacetylase 0.0316 0.0697 0.2224
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0084 0.1375
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0133 0.0422
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0178 0.0565
Loa Loa (eye worm) hypothetical protein 0.0099 0.0209 0.2985
Brugia malayi ecdysteroid receptor 0.0021 0.0032 0.0419
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0121
Schistosoma mansoni hypothetical protein 0.0082 0.0171 0.0543
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0077 0.0071
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.0036 0.0031
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0178 0.0565
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0032 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0114 0.163
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0004 0.0008
Entamoeba histolytica hypothetical protein 0.0181 0.0393 0.6619
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0007 0.0086
Loa Loa (eye worm) hypothetical protein 0.0263 0.0578 0.8297
Toxoplasma gondii histone deacetylase HDAC3 0.0269 0.0592 0.0586
Echinococcus granulosus roundabout 2 0.0016 0.002 0.0062
Echinococcus granulosus histone deacetylase 1 0.0269 0.0592 0.1889
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0019 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0021 0.029
Loa Loa (eye worm) glutaminase 0.0277 0.061 0.8755
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0091 0.13
Onchocerca volvulus 0.0008 0.0003 0.005
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0009 0.0006 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.0011
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0032 0.0586
Trichomonas vaginalis rotamase, putative 0.0034 0.0063 0.1028
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0033 0.0467
Loa Loa (eye worm) hypothetical protein 0.0256 0.0561 0.8049
Echinococcus multilocularis nibrin 0.002 0.003 0.0079
Brugia malayi ImpB/MucB/SamB family protein 0.0099 0.0209 0.2819
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0032 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0036 0.0513
Giardia lamblia DINP protein human, muc B family 0.008 0.0165 0.2723
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0052 0.0858
Echinococcus granulosus acetylcholinesterase 0.0065 0.0133 0.0422
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0148 0.03
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0077 0.0242
Echinococcus multilocularis GPCR, family 2 0.0048 0.0093 0.025
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0165 0.0357 0.0968
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0077 0.0071
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0008 0.0003 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0148 0.246
Trypanosoma brucei histone deacetylase 1 0.0269 0.0592 0.8494
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0274
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.012 0.0323
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0061 0.0864
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Onchocerca volvulus 0.0012 0.0012 0.0219
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0002
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0012 0.0007
Brugia malayi Cation transporter family protein 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0463
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0044 0.0727
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0178 0.0481
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Leishmania major DNA polymerase kappa, putative 0.0023 0.0036 0.0516
Schistosoma mansoni DNA ligase IV 0.002 0.003 0.0093
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Echinococcus granulosus dna polymerase kappa 0.01 0.0211 0.0672
Echinococcus granulosus dual specificity 0.0181 0.0393 0.1253
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0077 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0084 0.0267
Loa Loa (eye worm) hypothetical protein 0.0183 0.0397 0.5694
Loa Loa (eye worm) hypothetical protein 0.005 0.0097 0.1385
Leishmania major DNA polymerase kappa, putative 0.008 0.0165 0.2368
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0236 0.0516 0.0506
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0091 0.1228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0091 0.0289
Brugia malayi steroid hormone receptor 0.0021 0.0032 0.0419
Brugia malayi hypothetical protein 0.0036 0.0066 0.0878
Trypanosoma brucei unspecified product 0.0094 0.0196 0.2806
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0077 0.0071
Onchocerca volvulus 0.0041 0.0077 0.1437
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0031 0.043
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0032 0.0099
Schistosoma mansoni hypothetical protein 0.0048 0.0093 0.0294
Schistosoma mansoni histone deacetylase 0.0269 0.0592 0.1889
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.003 0.0493
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.003 0.002
Echinococcus granulosus histone deacetylase 3 0.0269 0.0592 0.1889
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.0019 0.0263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0052 0.0858
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0234 0.3349
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.0419
Echinococcus granulosus nAChR subunit 0.0008 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0033 0.0067
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0576 0.1283 0.1274
Echinococcus granulosus muscleblind protein 0.0302 0.0666 0.2125
Loa Loa (eye worm) hypothetical protein 0.0122 0.0261 0.3736
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0289
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0069 0.0986
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0069 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0091 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Onchocerca volvulus 0.0012 0.0012 0.0219
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0055 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0289
Schistosoma mansoni histone deacetylase 4 5 0.0316 0.0697 0.2224
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0776
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.0434 0.7314
Schistosoma mansoni hypothetical protein 0.0082 0.0171 0.0543
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0014 0.0017 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0031 0.0025
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0007 0.0091
Brugia malayi MH2 domain containing protein 0.0008 0.0004 0.004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0061 0.0867
Brugia malayi Histone deacetylase family protein 0.0316 0.0697 0.9443
Brugia malayi Smad1 0.0008 0.0004 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0084 0.1383
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0007 0.0086
Echinococcus granulosus twitchin 0.0017 0.0023 0.0072
Onchocerca volvulus 0.0012 0.0012 0.0219
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0472
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0269 0.0592 0.9703
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0033 0.0023
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0033 0.0067
Echinococcus granulosus alkaline phosphatase 0.0165 0.0357 0.1138
Echinococcus multilocularis replication factor c subunit 1 0.002 0.003 0.0079
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0231 0.0506 0.1614
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.018 0.039 0.559
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0069 0.0186
Onchocerca volvulus 0.0011 0.001 0.0176
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0014 0.0017 0.0011
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0009 0.0006 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0211 0.3025
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0148 0.2122
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0019 0.0248
Brugia malayi jmjC domain containing protein 0.0016 0.0021 0.0274
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0095 0.1352
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0165 0.0357 0.0968
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0031 0.043
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0031 0.05
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0021 0.0065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0463
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0148 0.2
Trypanosoma cruzi histone deacetylase 1, putative 0.0269 0.0592 0.8495
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0021 0.0055
Trypanosoma cruzi DNA polymerase eta, putative 0.0099 0.0209 0.2988
Schistosoma mansoni vesicular amine transporter 0.0016 0.002 0.0062
Trypanosoma brucei unspecified product 0.0051 0.0099 0.1413
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0007
Brugia malayi nuclear hormone receptor 0.0021 0.0032 0.0419
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.003 0.0024
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0084 0.1375
Trypanosoma brucei unspecified product 0.0051 0.0099 0.1413
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0006 0.0072
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0009 0.0006 0.0016
Onchocerca volvulus 0.0031 0.0055 0.1024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0042 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Mycobacterium ulcerans hypothetical protein 0.0023 0.0036 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0097 0.1387
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0052 0.0046
Mycobacterium ulcerans chorismate synthase 0.4445 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0114 0.163
Onchocerca volvulus 0.0101 0.0212 0.401
Loa Loa (eye worm) histone deacetylase 0.0316 0.0697 1
Plasmodium vivax chorismate synthase 0.4445 1 1
Brugia malayi hypothetical protein 0.0153 0.0331 0.4475
Entamoeba histolytica protein kinase, putative 0.0181 0.0393 0.6619
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0007 0.0091
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0083 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni hypothetical protein 0.0103 0.0218 0.0694
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0419
Schistosoma mansoni smad 0.0008 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.001 0.002
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0033 0.0104
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0098 0.0207 0.2792
Brugia malayi Carboxylesterase family protein 0.0011 0.001 0.0126
Brugia malayi SWIRM domain containing protein 0.0041 0.0077 0.1028
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.001 0.003
Onchocerca volvulus 0.0098 0.0207 0.3902
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.0419
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0033 0.0542
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.001 0.0166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.0036 0.0031
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0017 0.0043
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0234 0.3347
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0021 0.0065
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0052 0.0046
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0033 0.0023
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.0393 0.5637
Schistosoma mansoni hypothetical protein 0.0082 0.0171 0.0543
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.0019 0.0248
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0008 0.0003 0.0008
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0157
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0099
Echinococcus multilocularis tumor protein p63 0.0688 0.1536 0.4173
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0021 0.0295
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0123 0.0392
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0234 0.383
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0084
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0019 0.0058
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0716
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.0084 0.1204
Loa Loa (eye worm) RNA binding protein 0.0063 0.0127 0.1809
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0052 0.0544
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0148 0.2
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0019 0.0058
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0256 0.0561 0.179
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.0019 0.0058
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0077 0.1093
Echinococcus granulosus conserved hypothetical protein 0.0014 0.0017 0.005
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0234 0.3912
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0077 0.0071
Brugia malayi Muscleblind-like protein 0.0302 0.0666 0.9025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Giardia lamblia DNA damage repair protein 0.0023 0.0036 0.0522
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0033 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0211 0.3025
Echinococcus multilocularis dna polymerase eta 0.0099 0.0209 0.0565
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Schistosoma mansoni histone deacetylase hda2 0.0322 0.071 0.2268
Brugia malayi nuclear receptor NHR-88 0.001 0.0007 0.0086
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0033 0.0067
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0032 0.0099
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0083 0.1355
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0077 0.0071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0472
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0234 0.0744
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0032 0.0099
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0576 0.1283 0.1274
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0009 0.0115
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0234 0.0744
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.0084 0.1202
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0493
Schistosoma mansoni hypothetical protein 0.031 0.0684 0.2184
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0077 0.0071
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0007
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0072 0.0148 0.2118
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0044 0.0695
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0009 0.0006 0.0014
Schistosoma mansoni amine oxidase 0.0041 0.0077 0.0242
Brugia malayi 6-phosphofructokinase 0.011 0.0234 0.3159
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0021 0.0065
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0033 0.0469
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.1526
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0148 0.0138
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0033 0.0028
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0007 0.002
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.0019 0.0248
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.0019 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0107
Schistosoma mansoni cpg binding protein 0.0031 0.0054 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0004 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Leishmania major importin beta-1 subunit, putative 0.0024 0.0038 0.0543
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0042 0.0602
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.005 0.0712
Brugia malayi Histone deacetylase family protein 0.0316 0.0697 0.9443
Loa Loa (eye worm) hypothetical protein 0.0302 0.0666 0.9558
Loa Loa (eye worm) glutaminase 2 0.0277 0.061 0.8755
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0033 0.0467
Echinococcus multilocularis microtubule associated protein 2 0.1396 0.3129 0.8504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0419
Echinococcus multilocularis histone deacetylase 6 0.0316 0.0697 0.1891
Leishmania major histone deacetylase, putative 0.0269 0.0592 0.8495
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0033 0.0006
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.2542
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0077 0.0155
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0032 0.0099
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.037 0.0818 1
Trypanosoma brucei histone deacetylase, putative 0.0316 0.0697 1
Echinococcus granulosus snurportin 1 0.031 0.0684 0.2184
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0036 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Brugia malayi RNA binding protein 0.0063 0.0127 0.1708
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.0019 0.0263
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0535 0.1192 0.242
Brugia malayi Importin beta-1 subunit 0.0029 0.0051 0.0676
Schistosoma mansoni importin beta-1 0.0029 0.0051 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.0419
Plasmodium vivax patched family protein, putative 0.0012 0.0012 0.0007
Schistosoma mansoni amine oxidase 0.0041 0.0077 0.0242
Loa Loa (eye worm) histone deacetylase 3 0.0269 0.0592 0.8494
Echinococcus granulosus microtubule associated protein 2 0.1396 0.3129 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0077 0.0242
Echinococcus granulosus phd:f box containing protein 0.0016 0.0021 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0982
Onchocerca volvulus 0.0021 0.0033 0.0611
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0052 0.0793
Plasmodium falciparum importin beta, putative 0.0029 0.0051 0.0045
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0084 0.0267
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0258 0.3697
Trypanosoma brucei DNA polymerase IV, putative 0.0094 0.0196 0.2806
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.002 0.0053
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0234 0.3349
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0258 0.3697
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0234 0.0416
Leishmania major hypothetical protein, conserved 0.0016 0.0021 0.0295
Brugia malayi hypothetical protein 0.0041 0.0077 0.1028
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0032 0.0099
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.001 0.0029
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0133 0.1896
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0493
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0007 0.002
Entamoeba histolytica recQ family DNA helicase 0.001 0.0008 0.0082
Schistosoma mansoni histone deacetylase 4 5 0.0316 0.0697 0.2224
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0077 0.0067
Toxoplasma gondii histone deacetylase HDAC2 0.0269 0.0592 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.0419
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0148 0.0241
Brugia malayi Patched related family protein 4 0.0012 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0127 0.0402
Onchocerca volvulus 0.0011 0.001 0.0176
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0052 0.0046
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0069 0.1081
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0052 0.0022
Trichomonas vaginalis glutaminase, putative 0.0277 0.061 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0033 0.0437
Echinococcus granulosus neuroglian 0.0016 0.002 0.0062
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Schistosoma mansoni microtubule-associated protein tau 0.1396 0.3129 1
Toxoplasma gondii ATPase, AAA family protein 0.002 0.003 0.0024
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0077 0.1093
Schistosoma mansoni DNA polymerase eta 0.0099 0.0209 0.0664
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0371
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0031 0.05
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0148 0.246
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0207
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0605 0.1349 0.1344
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0093 0.1323
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.0441 0.1406
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0051 0.0045
Brugia malayi Carboxylesterase family protein 0.0065 0.0133 0.179
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0033 0.0006
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0069 0.0927
Toxoplasma gondii exonuclease III APE 0.0019 0.0028 0.0022
Loa Loa (eye worm) Smad1 0.0008 0.0004 0.0042
Trypanosoma brucei histone deacetylase 3 0.0316 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0148 0.0138
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0025 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0004 0.0042
Brugia malayi Carboxylesterase family protein 0.0011 0.001 0.0126
Brugia malayi histone deacetylase 1 (HD1) 0.0269 0.0592 0.8021
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.003 0.0422
Brugia malayi Carboxylesterase family protein 0.0011 0.001 0.0126
Echinococcus multilocularis cpg binding protein 0.0031 0.0054 0.0145
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0174 0.0555
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0133 0.0359
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0021 0.0015
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0007 0.0017
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.2192 0.4924 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.001 0.003
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0077 0.0071
Brugia malayi MH1 domain containing protein 0.0008 0.0004 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0084 0.0267
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0166
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0008 0.0019
Loa Loa (eye worm) LGC-31 protein 0.0015 0.0019 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0042 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0121
Echinococcus granulosus intestinal type alkaline phosphatase 0.0165 0.0357 0.1138
Brugia malayi Histone deacetylase 1 0.0269 0.0592 0.8021
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Echinococcus granulosus histone deacetylase 6 0.0316 0.0697 0.2224
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0033 0.0027
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0028 0.024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0234 0.0474
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0084 0.134
Brugia malayi hypothetical protein 0.001 0.0007 0.0086
Onchocerca volvulus Histone deacetylase 10 homolog 0.0133 0.0285 0.5386
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.0019 0.005
Plasmodium falciparum histone deacetylase 1 0.0269 0.0592 0.0586
Toxoplasma gondii histone deacetylase HDAC1 0.0316 0.0697 0.0691
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0148 0.246
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0032 0.0419
Trypanosoma brucei DNA polymerase eta, putative 0.0099 0.0209 0.2986
Loa Loa (eye worm) oxidoreductase 0.0021 0.0033 0.0463
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0069 0.1134
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0075 0.1207
Loa Loa (eye worm) histone deacetylase 7A 0.0316 0.0697 1
Brugia malayi nuclear receptor RXR 0.001 0.0007 0.0086
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0093 0.1249
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0036 0.0031
Onchocerca volvulus 0.0011 0.001 0.0176
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.0019 0.0058
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0007 0.0091
Brugia malayi RE40412p 0.0014 0.0017 0.0214
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Loa Loa (eye worm) DR-78 0.001 0.0007 0.0091
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0033 0.0463
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0166
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Brugia malayi RNA, U transporter 1 0.0083 0.0171 0.2315
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.0434 0.5876
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0166
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.003 0.0093
Plasmodium vivax importin-beta 2, putative 0.0029 0.0051 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.0011
Echinococcus multilocularis histone deacetylase 7 0.0316 0.0697 0.1891
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0107 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.0036 0.0516
Brugia malayi conserved hypotetical protein 0.001 0.0007 0.0086
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0234 0.2783
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0033 0.0067
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0004 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0032 0.0419
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0316 0.0858
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.0019 0.005
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0148 0.2
Echinococcus multilocularis alkaline phosphatase 0.0165 0.0357 0.0968
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0008 0.0024
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0133 0.0359
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.001 0.003
Loa Loa (eye worm) hypothetical protein 0.0141 0.0304 0.4354
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.001 0.003
Brugia malayi hypothetical protein 0.0016 0.0022 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0211 0.3025
Echinococcus multilocularis histone deacetylase 8 0.0133 0.0285 0.0772
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0052 0.083
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.003 0.0024
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0067
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0044 0.0629
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0234 0.383
Schistosoma mansoni histone deacetylase hda2 0.0133 0.0285 0.0908
Loa Loa (eye worm) hypothetical protein 0.0054 0.0107 0.1526
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0128
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Echinococcus granulosus flap endonuclease 1 0.0026 0.0044 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.0419
Entamoeba histolytica protein kinase domain containing protein 0.0181 0.0393 0.6619
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0032 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0004 0.0009
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.0019 0.005
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.0019 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0148 0.2122
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0038 0.0543
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0069 0.0218
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0007 0.0086
Onchocerca volvulus 0.0015 0.0019 0.0347
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0033 0.0027
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0007 0.002
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0256 0.0561 0.1522
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0052 0.0022
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0008 0.0002
Schistosoma mansoni DNA helicase recq5 0.002 0.0031 0.0095
Brugia malayi CXXC zinc finger family protein 0.0029 0.005 0.0673
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0044 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0032 0.0586
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0077 0.0242
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Brugia malayi hypothetical protein 0.002 0.003 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Brugia malayi nuclear receptor RXR 0.0011 0.001 0.0121
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0174 0.2495
Schistosoma mansoni alkaline phosphatase 0.0165 0.0357 0.1138
Loa Loa (eye worm) hypothetical protein 0.0071 0.0144 0.2061
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0173
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0091 0.0289
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0178 0.2542
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.0084 0.1204
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0084 0.1383
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0166
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.003 0.0396
Onchocerca volvulus 0.0015 0.0019 0.0347
Schistosoma mansoni hypothetical protein 0.0086 0.0178 0.0567
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0055 0.0173
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0032 0.0099
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0007 0.0017
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0021 0.0065
Entamoeba histolytica hypothetical protein 0.0036 0.0066 0.1055
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.0019 0.005
Leishmania major hypothetical protein, unknown function 0.0014 0.0017 0.0231
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Giardia lamblia Replication factor C, subunit 1 0.002 0.003 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0036 0.0516
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0033 0.0028
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0033 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0032 0.0444
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0123 0.0392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.001
Brugia malayi nuclear receptor NHR-67 0.001 0.0007 0.0086
Echinococcus multilocularis muscleblind protein 1 0.0302 0.0666 0.1807
Brugia malayi Pre-SET motif family protein 0.0031 0.0055 0.0733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0091 0.0246
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0044 0.0118
Schistosoma mansoni ran 0.0021 0.0033 0.0104
Echinococcus multilocularis 0.0041 0.0077 0.0206
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.001 0.002
Trypanosoma cruzi histone deacetylase, putative 0.0316 0.0697 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0033 0.0542
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0075 0.0069
Onchocerca volvulus 0.0021 0.0032 0.0586
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0006 0.0068
Loa Loa (eye worm) hypothetical protein 0.0065 0.0133 0.1896
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0033 0.0465
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0099
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0127 0.0342
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.003 0.0493
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0083 0.0077
Schistosoma mansoni hypothetical protein 0.0082 0.0171 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0493
Plasmodium vivax SET domain protein, putative 0.0031 0.0055 0.0049
Brugia malayi hypothetical protein 0.0016 0.002 0.0263
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus multilocularis histone deacetylase 1 0.0269 0.0592 0.1606
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0084 0.12
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0256 0.0561 0.179
Loa Loa (eye worm) carboxylesterase 0.0011 0.001 0.0133
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0166
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0236 0.0516 0.0993
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0044 0.0625
Leishmania major DNA polymerase eta, putative 0.0049 0.0095 0.1352
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0069 0.0986
Schistosoma mansoni topbp1 0.002 0.003 0.0093
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0008 0.0003 0.0036
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0316 0.4284
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.002 0.0263
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0009 0.0006 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.003 0.0493
Schistosoma mansoni histone deacetylase 1 2 3 0.0133 0.0285 0.0908
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0033 0.0067
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.003 0.0452
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0029 0.0052 0.0046
Schistosoma mansoni flap endonuclease-1 0.0024 0.0039 0.0121
Brugia malayi nuclear hormone receptor 0.001 0.0007 0.0086
Loa Loa (eye worm) hypothetical protein 0.0065 0.0133 0.1896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.01 0.0203
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0017 0.0011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0084 0.0079
Echinococcus granulosus Immunoglobulin 0.0016 0.002 0.0062
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.012 0.0323
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0157
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.0592
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.001 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0234 0.3912
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0397
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.0462
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0554 0.1234 0.3941
Onchocerca volvulus 0.0021 0.0033 0.0611
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0004 0.0009
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0073 0.015 0.0478
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0048 0.0093 0.0294
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0021 0.0055
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.003 0.0493
Trypanosoma brucei histone deacetylase 2 0.0133 0.0285 0.4082
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0127 0.0402
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0127 0.1809
Echinococcus multilocularis muscleblind protein 0.0302 0.0666 0.1807
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0326 0.4407
Onchocerca volvulus 0.0015 0.0019 0.0347
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0063 0.0839
Brugia malayi hypothetical protein 0.0012 0.0012 0.0157
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0032 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.0444
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0236 0.0516 0.1047
Echinococcus multilocularis neuroglian 0.0016 0.002 0.0053
Loa Loa (eye worm) carboxylesterase 0.0065 0.0133 0.1896
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0093 0.1249
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.003 0.0024
Plasmodium vivax histone deacetylase 1, putative 0.0269 0.0592 0.0586
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0181 0.0393 0.5635
Echinococcus granulosus expressed protein 0.0034 0.0063 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0052 0.0046
Schistosoma mansoni hypothetical protein 0.0084 0.0174 0.0555
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0028 0.0018
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0605 0.1349 0.1323
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0077 0.0047
Entamoeba histolytica recQ family helicase, putative 0.001 0.0007 0.0067
Loa Loa (eye worm) hypothetical protein 0.0101 0.0212 0.3038
Plasmodium vivax histone deacetylase, putative 0.0133 0.0285 0.0279
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0174 0.0472
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0269 0.0592 0.9703
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0111
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0095 0.0089
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0021 0.0055
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.0019 0.0248
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0033 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.0444
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0084 0.134
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0084 0.0227
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0419
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Brugia malayi RE40412p 0.0014 0.0017 0.0214
Echinococcus granulosus neuroligin 0.0011 0.001 0.003
Onchocerca volvulus 0.0012 0.0012 0.0219
Echinococcus multilocularis expressed conserved protein 0.0187 0.0407 0.1103
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Schistosoma mansoni glutaminase 0.0277 0.061 0.1947
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0006 0.0072
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0021 0.0065
Echinococcus multilocularis snurportin 1 0.031 0.0684 0.1857
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0031 0.0428
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0133 0.0422
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.0019 0.0058
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.0019 0.005
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.037 0.0818 0.0809
Schistosoma mansoni zinc finger protein 0.001 0.0007 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0419
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0528 0.8656
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.0084 0.1204
Leishmania major UDP-galactopyranose mutase 0.0041 0.0077 0.1093
Brugia malayi MH2 domain containing protein 0.0121 0.0258 0.3491
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0069 0.0186
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0015 0.0019 0.0058
Schistosoma mansoni cpg binding protein 0.0029 0.005 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0084
Toxoplasma gondii chorismate synthase, putative 0.4445 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.0084 0.1204
Echinococcus multilocularis neuroligin 0.0011 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0302 0.0666 0.9558
Loa Loa (eye worm) hypothetical protein 0.0072 0.0148 0.2118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni histone deacetylase 0.0269 0.0592 0.1889
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0055 0.0173
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0009 0.0006 0.0077
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0084 0.0267
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0004 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.0211 0.3025
Echinococcus multilocularis Immunoglobulin 0.0016 0.002 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.0066 0.1055
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0127 0.0402
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0009 0.0118
Plasmodium vivax protein kinase Crk2 0.0044 0.0084 0.0079
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.0019 0.0248
Echinococcus multilocularis histone deacetylase 6 0.0316 0.0697 0.1891
Echinococcus multilocularis histone deacetylase 6 0.0322 0.071 0.1929
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.0019 0.0248
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.001 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0211 0.3023
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0234 0.3346
Leishmania major DNA polymerase eta, putative 0.0099 0.0209 0.2988
Brugia malayi tailless protein 0.001 0.0007 0.0086
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0009 0.0006 0.0072
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0234 0.0744
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0021 0.0065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0069 0.0218
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0033 0.0067
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0032 0.0444
Brugia malayi ImpB/MucB/SamB family protein 0.0073 0.015 0.2029
Entamoeba histolytica recQ family helicase, putative 0.002 0.0031 0.0459
Trichomonas vaginalis DNA polymerase eta, putative 0.01 0.0211 0.3461
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0073 0.015 0.2148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0033 0.0463
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0148 0.0138
Brugia malayi Flap endonuclease-1 0.0026 0.0044 0.059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.0419
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0009 0.0006 0.0096
Brugia malayi hypothetical protein 0.0012 0.0012 0.0157
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0181 0.0393 0.5637
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0016 0.002 0.0062
Schistosoma mansoni nAChR subunit 0.0015 0.0019 0.0058
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0234 0.0633
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0031 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Schistosoma mansoni hypothetical protein 0.0084 0.0174 0.0555
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0009 0.0006 0.0068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0148 0.0138
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0718
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Brugia malayi Pre-SET motif family protein 0.0212 0.0462 0.6263
Onchocerca volvulus 0.0011 0.001 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.002 0.003 0.0493
Brugia malayi histone deacetylase 3 (HD3) 0.0269 0.0592 0.8021
Brugia malayi Carboxylesterase family protein 0.0011 0.001 0.0126
Loa Loa (eye worm) acetyltransferase 0.0147 0.0316 0.4536
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0032 0.0099
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.0019 0.005
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0033 0.0103
Loa Loa (eye worm) ACC-1 protein 0.0015 0.0019 0.0263
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.0036 0.0114
Toxoplasma gondii hypothetical protein 0.0012 0.0012 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0009 0.0006 0.0016
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0234 0.3346
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.0684 0.9822
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0091 0.0289
Echinococcus multilocularis smad 0.0008 0.0004 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0007 0.002
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0017 0.0011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.012 0.038
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0069 0.0218
Entamoeba histolytica hypothetical protein 0.0036 0.0066 0.1055
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0052 0.0046
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0028 0.0057
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0004 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Schistosoma mansoni alkaline phosphatase 0.0165 0.0357 0.1138
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0077 0.0242
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0174 0.2356
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0031 0.0095
Brugia malayi CHE-14 protein 0.0085 0.0178 0.24
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0026 0.0053
Echinococcus granulosus bloom syndrome protein 0.002 0.0031 0.0095
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0091
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.003 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0084 0.12
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.029
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0033 0.0467
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.002 0.0263
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0628
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.0434 0.1177
Echinococcus multilocularis protein patched 0.0085 0.0178 0.0481
Echinococcus granulosus dna polymerase eta 0.0099 0.0209 0.0664
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0009 0.0003
Schistosoma mansoni 3-dehydroquinate synthase 0.0236 0.0516 0.1647
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.0019 0.005
Echinococcus multilocularis roundabout 2 0.0016 0.002 0.0053
Onchocerca volvulus 0.0015 0.0019 0.0347
Loa Loa (eye worm) histone deacetylase 11 0.0133 0.0285 0.4081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.0444
Brugia malayi hypothetical protein 0.001 0.0007 0.0086
Echinococcus granulosus tumor protein p63 0.0688 0.1536 0.4908
Schistosoma mansoni hypothetical protein 0.0084 0.0174 0.0555
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0033 0.0023
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.0084 0.1202
Onchocerca volvulus Putative nachr subunit 0.0015 0.0019 0.0347
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.002
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0033 0.0006
Schistosoma mansoni neurotransmitter gated ion channel 0.0008 0.0003 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.0011
Onchocerca volvulus 0.0012 0.0012 0.0219
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0009 0.0006 0.0096
Echinococcus multilocularis Niemann Pick C1 protein 0.0285 0.0626 0.17
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0165 0.2366
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0007 0.0002
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0084 0.0227
Leishmania major GTP-binding protein, putative 0.0021 0.0033 0.0472
Brugia malayi hypothetical protein 0.0011 0.001 0.0121
Leishmania major DNA damage repair protein, putative 0.0023 0.0036 0.0516
Leishmania major histone deacetylase, putative 0.0316 0.0697 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.015 0.0305
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0061 0.0867
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0084 0.12
Loa Loa (eye worm) RecQ helicase 0.002 0.0031 0.0426
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0009 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Leishmania major histone deacetylase, putative 0.0269 0.0592 0.8495
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0007 0.012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0028 0.042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0017
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0061 0.0867
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0004 0.0009
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Schistosoma mansoni hypothetical protein 0.0048 0.0093 0.0294
Echinococcus multilocularis dual specificity 0.0181 0.0393 0.1066
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0278
Brugia malayi jmjC domain containing protein 0.0061 0.0123 0.1662
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0107 0.0217
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0051 0.0135
Echinococcus granulosus cpg binding protein 0.0031 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus Niemann Pick C1 protein 0.0285 0.0626 0.1999
Echinococcus granulosus expressed conserved protein 0.0187 0.0407 0.1297
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0077 0.0206
Plasmodium vivax histone deacetylase 2, putative 0.0316 0.0697 0.0691
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0016 0.002 0.0062
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0007 0.002
Schistosoma mansoni topbp1 0.002 0.003 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0032 0.0419
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0032 0.0099
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.0087
Loa Loa (eye worm) histone deacetylase 1 0.0269 0.0592 0.8494
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.001 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.003 0.0424
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Echinococcus granulosus nAChR subunit 0.0015 0.0019 0.0058
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.003 0.0396
Trichomonas vaginalis histone deacetylase, putative 0.0269 0.0592 0.9703
Plasmodium vivax histone deacetylase, putative 0.0316 0.0697 0.0691
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.042
Echinococcus multilocularis protein dispatched 1 0.0098 0.0205 0.0555
Toxoplasma gondii zinc finger cdgsh type protein 0.0014 0.0017 0.0011
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.0019 0.0058
Onchocerca volvulus 0.0153 0.0331 0.6255
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0263
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.1089
Brugia malayi topoisomerase 0.002 0.003 0.0396
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0055 0.0173
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0084 0.0267
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0028 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.0444
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0084
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0148 0.03
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0444
Brugia malayi Patched family protein 0.0012 0.0012 0.0157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0166
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0008 0.0111
Loa Loa (eye worm) hypothetical protein 0.0151 0.0326 0.4667

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 4.4 uM Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
EC50 (binding) = 4.4 uM Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
Maximal efficacy (binding) = 32.4 % Maximal efficacy for GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
Maximal efficacy (binding) = 32.4 % Maximal efficacy for GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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