Detailed information for compound 339528

Basic information

Technical information
  • TDR Targets ID: 339528
  • Name: 6-[(2-amino-1H-imidazol-3-ium-3-yl)methyl]-5- chloro-1H-pyrimidine-2,4-dione
  • MW: 242.642 | Formula: C8H9ClN5O2+
  • H donors: 4 H acceptors: 4 LogP: 0.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(O)c(c(n1)C[n+]1cc[nH]c1N)Cl
  • InChi: 1S/C8H8ClN5O2/c9-5-4(12-8(16)13-6(5)15)3-14-2-1-11-7(14)10/h1-2H,3H2,(H4,10,11,12,13,15,16)/p+1
  • InChiKey: BUGFMISUFJLVFI-UHFFFAOYSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-[(2-azanyl-1H-imidazol-3-ium-3-yl)methyl]-5-chloro-1H-pyrimidine-2,4-dione
  • 6-[(2-amino-1H-imidazol-3-ium-3-yl)methyl]-5-chloro-uracil

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli thymidine phosphorylase Starlite/ChEMBL References
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Schistosoma mansoni lamin 0.0027 0.0088 0.0095
Loa Loa (eye worm) RGC/RGC protein kinase 0.0139 0.0709 0.0709
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0139 0.0709 0.4896
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0139 0.0151
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0046 0.005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0133 0.0144
Echinococcus granulosus flap endonuclease 1 0.0026 0.0084 0.0084
Brugia malayi Cytochrome P450 family protein 0.0022 0.0061 0.0076
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.011 0.0551 1
Onchocerca volvulus 0.0019 0.0046 0.0312
Echinococcus multilocularis tyrosine kinase 0.0139 0.0709 0.0709
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0096 0.0081
Schistosoma mansoni smad1 5 8 and 0.0014 0.0017 0.0019
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0021 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0046 0.0046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0164 0.0846 0.1004
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0183 0.0183
Trichomonas vaginalis esterase, putative 0.0036 0.0139 0.0769
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0173 0.0187
Onchocerca volvulus 0.0041 0.017 0.1168
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0046 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0139 0.0769
Schistosoma mansoni histamine h1 receptor 0.0019 0.0046 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0009 0.0009
Echinococcus multilocularis serotonin receptor 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0012 0.0009 0.0051
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.0058 0.0071
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0169 0.0876 0.0949
Schistosoma mansoni amine GPCR 0.0019 0.0046 0.005
Echinococcus multilocularis geminin 0.0169 0.0876 0.0876
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0021
Echinococcus granulosus death domain containing protein 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0021 0.0021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0046 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Mycobacterium ulcerans hypothetical protein 0.0028 0.0096 0.0112
Trypanosoma cruzi extracellular receptor, putative 0.0139 0.0709 0.5497
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0046 0.0046
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.005
Onchocerca volvulus 0.0036 0.0139 0.0954
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0061 0.0072
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0061 0.0072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0139 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0021 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.017 0.017
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0088 0.0088
Brugia malayi G-protein coupled receptor 0.0019 0.0046 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0242
Brugia malayi Serotonin receptor 0.0019 0.0046 0.0057
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0139 0.0709 0.0709
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.001 0.0167
Mycobacterium leprae Probable lipase LipE 0.0036 0.0139 0.0592
Schistosoma mansoni cpg binding protein 0.0027 0.0091 0.0098
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0021 0.0021
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0258 0.1366 0.1684
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0061 0.004
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0046 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0061 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0091 0.0091
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0125 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0242
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.1289 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0088 0.0088
Echinococcus granulosus neuropeptide receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus GPCR family 3 C terminal 0.024 0.1267 0.1267
Echinococcus granulosus neuropeptide s receptor 0.0533 0.2889 0.2889
Echinococcus granulosus lamin dm0 0.0027 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0269 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0019 0.0046 0.0312
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0139 0.0709 0.0709
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0046 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0046 0.0046
Schistosoma mansoni rab6-interacting 0.0041 0.017 0.0184
Onchocerca volvulus 0.0041 0.017 0.1168
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0009 0.0009
Schistosoma mansoni tyrosine kinase 0.0139 0.0709 0.0768
Onchocerca volvulus 0.0019 0.0046 0.0312
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0061 0.004
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0009 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0028 0.0028
Schistosoma mansoni smad1 5 8 and 0.0014 0.0017 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0061 0.004
Schistosoma mansoni hypothetical protein 0.0014 0.002 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0166 0.0166
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0009 0.0009
Echinococcus granulosus tumor protein p63 0.0334 0.1788 0.1788
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0009 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0164 0.0164
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0061 0.0061
Brugia malayi RE15519p 0.0019 0.0046 0.0057
Brugia malayi MH2 domain containing protein 0.0014 0.0017 0.0021
Brugia malayi bZIP transcription factor family protein 0.0084 0.0404 0.0498
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.003 0.016
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0021 0.0021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0359 0.2784
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0001 0.0009
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0096 0.0742
Echinococcus multilocularis lamin 0.0027 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Onchocerca volvulus 0.0019 0.0046 0.0312
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0139 0.0133
Schistosoma mansoni metabotropic glutamate receptor 0.1237 0.6785 0.735
Onchocerca volvulus 0.0066 0.0304 0.2098
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0054 0.0066
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0018 0.0039 0.0211
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0105 0.0524 0.0524
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0391
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0009 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0926 0.516
Brugia malayi putative neuropeptide receptor 0.0019 0.0046 0.0057
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0084 0.0084
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0009 0.0011
Brugia malayi MH1 domain containing protein 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi Cytochrome P450 family protein 0.0031 0.0109 0.0135
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Loa Loa (eye worm) Smad1 0.0014 0.0017 0.0017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0061 0.004
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0061 0.004
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0139 0.2343
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.0009
Brugia malayi hypothetical protein 0.0041 0.017 0.021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1263 0.1263
Onchocerca volvulus 0.0019 0.0046 0.0312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0139 0.0139
Schistosoma mansoni lipoxygenase 0.0173 0.0901 0.0976
Brugia malayi Receptor family ligand binding region containing protein 0.0139 0.0709 0.0874
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0223 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0061 0.004
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0001 0.00000095829
Brugia malayi MH2 domain containing protein 0.0014 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.0546 0.0546
Schistosoma mansoni protein kinase 0.0139 0.0709 0.0768
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0217 0.1686
Schistosoma mansoni lipoxygenase 0.0248 0.1314 0.1423
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0028 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0359 0.2784
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1678 0.9232 1
Echinococcus granulosus thymidine phosphorylase 0.1531 0.8415 0.8415
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trichomonas vaginalis set domain proteins, putative 0.0272 0.1446 0.8059
Schistosoma mansoni neuropeptide receptor 0.0019 0.0046 0.005
Echinococcus multilocularis receptor type guanylyl cyclase 0.0139 0.0709 0.0709
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0061 0.0072
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.005
Onchocerca volvulus 0.0019 0.0046 0.0312
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0046 0.0046
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0046 0.0046
Brugia malayi Pre-SET motif family protein 0.0239 0.1263 0.1557
Echinococcus granulosus cpg binding protein 0.0029 0.0099 0.0099
Brugia malayi Serotonin receptor 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0009 0.0009
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0125 0.0125
Schistosoma mansoni opsin-like receptor 0.0019 0.0046 0.005
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0135
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0096 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0524 0.0524
Onchocerca volvulus 0.0019 0.0046 0.0312
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0359 0.0359
Onchocerca volvulus 0.0139 0.0709 0.4896
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0009 0.0009
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0269 0.0269
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0028 0.0214
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0046 0.0046
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0085
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0359 0.0442
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0061 0.0072
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.017 0.017
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0061 0.0259
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.017 0.017
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0001 0.0001
Brugia malayi hypothetical protein 0.0139 0.0709 0.0874
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0017 0.0017
Onchocerca volvulus 0.0272 0.1446 1
Schistosoma mansoni rab6-interacting 0.0041 0.017 0.0184
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Schistosoma mansoni neuropeptide receptor 0.0019 0.0046 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0223 0.0223
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0046 0.0046
Schistosoma mansoni netrin receptor unc5 0.0014 0.002 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0319 0.1773
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0021 0.0025
Toxoplasma gondii ABC1 family protein 0.0036 0.0139 0.2526
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0013 0.001 0.0167
Loa Loa (eye worm) GABA receptor subunit 0.0054 0.0237 0.0237
Schistosoma mansoni cpg binding protein 0.0029 0.0099 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus Smad4 0.0014 0.0017 0.0017
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0359 0.0359
Echinococcus granulosus g protein coupled receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0064 0.0292 0.0292
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.005
Mycobacterium tuberculosis Conserved protein 0.0028 0.0096 0.0081
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0139 0.0709 0.0709
Schistosoma mansoni Smad4 0.0014 0.0017 0.0019
Echinococcus multilocularis importin subunit beta 1 0.0022 0.0062 0.0062
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0139 0.0709 0.0709
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0028 0.0214
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0061 0.004
Echinococcus granulosus glutamate receptor 2 0.0139 0.0709 0.0709
Brugia malayi intermediate filament protein 0.0027 0.0088 0.0108
Brugia malayi jmjC domain containing protein 0.0109 0.0546 0.0673
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0139 0.0709 0.0709
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0139 0.0769
Onchocerca volvulus 0.0019 0.0046 0.0312
Echinococcus granulosus nmda type glutamate receptor 0.0139 0.0709 0.0709
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0009 0.0009
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0096 0.0112
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0096 0.0527
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0164 0.0846 0.3622
Brugia malayi isocitrate dehydrogenase 0.0016 0.0028 0.0034
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0009 0.0009
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0139 0.0769
Schistosoma mansoni amine GPCR 0.0019 0.0046 0.005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0011
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0139 0.0709 0.0709
Echinococcus granulosus neuropeptide receptor A26 0.0533 0.2889 0.2889
Mycobacterium ulcerans beta-lactamase 0.0036 0.0139 0.0164
Loa Loa (eye worm) hypothetical protein 0.0054 0.0237 0.0237
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0046 0.0046
Echinococcus granulosus smad 0.0014 0.0017 0.0017
Brugia malayi G-protein coupled receptor 0.0019 0.0046 0.0057
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0021 0.0021
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0084 0.1527
Brugia malayi Flap endonuclease-1 0.0026 0.0084 0.0104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0129 0.014
Echinococcus granulosus fmrfamide receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis importin beta-1, putative 0.0018 0.0039 0.0211
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0109 0.0129
Schistosoma mansoni intermediate filament proteins 0.0027 0.0088 0.0095
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0217 0.1686
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0001 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0125 0.2274
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0021 0.0021
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2332 0.2748
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0135
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0359 0.0389
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0125 0.2109
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0346 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0223 0.0223
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi topoisomerase 0.0011 0.0001 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0021 0.0021
Leishmania major hypothetical protein, conserved 0.005 0.0217 0.1686
Onchocerca volvulus Poor gastrulation protein homolog 0.024 0.1267 0.8757
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0135
Schistosoma mansoni adenoreceptor 0.0019 0.0046 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0269 0.0291
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0046 0.005
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0383 0.0415
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0061 0.0072
Brugia malayi MH1 domain containing protein 0.0014 0.0017 0.0021
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0061 0.0072
Brugia malayi metabotropic glutamate receptor type 2 0.0719 0.3923 0.4836
Schistosoma mansoni topbp1 0.0011 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0033 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0036 0.0139 0.0133
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0017 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0223 0.0275
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Echinococcus multilocularis thymidine phosphorylase 0.1531 0.8415 0.8415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0211 0.0211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0139 0.0709 0.0709
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0139 0.1079
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0046 0.0046
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0046 0.0057
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0096 0.0742
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Schistosoma mansoni hypothetical protein 0.0034 0.0129 0.014
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) RGC/RGC protein kinase 0.0139 0.0709 0.0709
Leishmania major importin beta-1 subunit, putative 0.0018 0.0039 0.0302
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0017 0.0017
Brugia malayi Smad1 0.0014 0.0017 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0378 0.2035 0.2035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0217 0.3662
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0061 0.004
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0046 0.0046
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0096 0.0742
Onchocerca volvulus 0.0012 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0058 0.0063
Brugia malayi Dopamine receptor protein 2 0.0019 0.0046 0.0057
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0046 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0001 0.0009
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Leishmania major extracellular receptor, putative 0.0139 0.0709 0.5497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Brugia malayi beta-lactamase 0.0036 0.0139 0.0171
Schistosoma mansoni jun-related protein 0.0068 0.0317 0.0343
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0217 0.3662
Brugia malayi Cation transporter family protein 0.0012 0.0009 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0046 0.0046
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0062 0.048
Brugia malayi beta-lactamase family protein 0.0036 0.0139 0.0171
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.0058 0.0058
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.0269 0.0269
Echinococcus granulosus tyrosine kinase 0.0139 0.0709 0.0709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0039 0.0211
Brugia malayi Importin beta-1 subunit 0.0022 0.0062 0.0076
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0019 0.0019
Onchocerca volvulus 0.0027 0.0088 0.06
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0378 0.2035 0.2035
Schistosoma mansoni flap endonuclease-1 0.0023 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.017 0.017
Schistosoma mansoni polycystin 1-related 0.0041 0.017 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0035 0.0133 0.0912
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0028 0.0028
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0133 0.0133
Brugia malayi metabotropic GABA-B receptor subtype 2 0.024 0.1267 0.1561
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0009 0.0009
Schistosoma mansoni DNA ligase IV 0.0011 0.0001 0.0001
Echinococcus granulosus GPCR family 2 0.0033 0.0125 0.0125
Echinococcus granulosus snurportin 1 0.0235 0.1239 0.1239
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Echinococcus multilocularis nmda type glutamate receptor 0.0139 0.0709 0.0709
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0061 0.0072
Brugia malayi hypothetical protein 0.005 0.0217 0.0268
Onchocerca volvulus 0.0019 0.0046 0.0312
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0001 0.0009
Brugia malayi hypothetical protein 0.0041 0.017 0.021
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0046 0.0046
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0139 0.0133
Echinococcus granulosus receptor type guanylyl cyclase 0.0139 0.0709 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.024 0.1267 0.1267
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.003 0.0503
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.121 0.141
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.003 0.0231
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0009 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0046 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Plasmodium falciparum flap endonuclease 1 0.0026 0.0084 0.1417
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1817 1 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0001 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0524 0.0645
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0001 0.0021
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0139 0.0709 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0125
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0269 0.0269
Brugia malayi neuropeptide F receptor 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0125
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0053 0.0232 0.0232
Brugia malayi Cytochrome P450 family protein 0.0041 0.0166 0.0204
Schistosoma mansoni importin beta-1 0.0022 0.0062 0.0067
Onchocerca volvulus Putative nachr subunit 0.0012 0.0009 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0217 0.3662
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.1794 1
Onchocerca volvulus 0.0012 0.0009 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0139 0.0139
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.0204 0.107 0.107
Brugia malayi follicle stimulating hormone receptor 0.0246 0.1304 0.1608
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0084 0.1417
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0359 0.2784
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0062
Schistosoma mansoni lamin 0.0027 0.0088 0.0095
Brugia malayi Bromodomain containing protein 0.0033 0.0125 0.0154
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0139 0.0139
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0084 0.0463
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0046 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0046 0.0046
Brugia malayi neuropeptide F receptor 0.0019 0.0046 0.0057
Brugia malayi Guanylyl cyclase protein 23 0.0139 0.0709 0.0874
Brugia malayi Cation transporter family protein 0.0059 0.0269 0.0331
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Plasmodium falciparum importin beta, putative 0.0022 0.0062 0.1044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0017 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0046 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0244 0.1289 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0217 0.3948
Echinococcus granulosus geminin 0.0169 0.0876 0.0876
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0404 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0061 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0046 0.0046
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0004 0.0005
Echinococcus multilocularis lamin dm0 0.0027 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.017 0.2864
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0084 0.0463
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.002
Brugia malayi Dopamine receptor 0.0019 0.0046 0.0057
Echinococcus granulosus serotonin receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0139 0.0769
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0046 0.0046
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0084 0.0652
Onchocerca volvulus 0.0036 0.0139 0.0954
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0028 0.0214
Echinococcus granulosus somatostatin receptor 0.0019 0.0046 0.0046
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0118 0.0594 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0096 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0139 0.0769
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0248 0.1314 0.1314
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0125 0.0154
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.017
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0061 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis glutamate receptor 2 0.0139 0.0709 0.0709
Onchocerca volvulus 0.0019 0.0046 0.0312
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0019 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0133 0.2414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Brugia malayi Doublecortin family protein 0.0041 0.017 0.021
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0046 0.0312
Mycobacterium ulcerans hypothetical protein 0.0036 0.0139 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni metabotropic glutamate receptor 0.0719 0.3923 0.425
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0001 0.00000095829
Loa Loa (eye worm) MH2 domain-containing protein 0.0204 0.107 0.107
Echinococcus multilocularis tumor protein p63 0.0334 0.1788 0.1788
Loa Loa (eye worm) hypothetical protein 0.005 0.0217 0.0217
Entamoeba histolytica hypothetical protein 0.0034 0.0129 0.0713
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0061 0.0072
Schistosoma mansoni cpg binding protein 0.0029 0.0099 0.0108
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0046 0.0046
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0347 0.0347
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0028 0.0214
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0383 0.0415
Schistosoma mansoni neuropeptide receptor 0.0019 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.0036 0.0139 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0125 0.0125
Brugia malayi Melatonin receptor type 1A 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0057 0.0257 0.0257
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0021 0.0108
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0421 0.0456
Mycobacterium ulcerans hypothetical protein 0.0028 0.0096 0.0112
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0173 0.0173
Echinococcus multilocularis peregrin 0.0033 0.0125 0.0125
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.1304 0.1304
Onchocerca volvulus Alhambra homolog 0.0033 0.0125 0.0858
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0139 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0139 0.0709 0.0709
Echinococcus granulosus peregrin 0.0033 0.0125 0.0125
Schistosoma mansoni biogenic amine receptor 0.0019 0.0046 0.005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0125 0.0136
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0021 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0046 0.0046
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0028 0.0464
Schistosoma mansoni myosin xvIII 0.0019 0.0046 0.005
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0378 0.2035 0.2035
Brugia malayi beta-lactamase family protein 0.0036 0.0139 0.0171
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.003 0.0503
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.0546 0.0546
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.003 0.003
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0109 0.0849
Mycobacterium tuberculosis Conserved protein 0.0036 0.0139 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Brugia malayi hypothetical protein 0.0066 0.0304 0.0375
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0009 0.0009
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0001 0.0021
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.0058 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Schistosoma mansoni amine GPCR 0.0019 0.0046 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0319 0.1773
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0053 0.0232 0.0232
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0109 0.0849
Echinococcus multilocularis Smad4 0.0014 0.0017 0.0017
Brugia malayi MH2 domain containing protein 0.0204 0.107 0.1319
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.002 0.0021
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0001 0.0006
Brugia malayi RNA, U transporter 1 0.0062 0.0286 0.0353
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0046 0.005
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.002 0.0024
Onchocerca volvulus 0.0049 0.0211 0.1451
Echinococcus multilocularis serotonin receptor 0.0019 0.0046 0.0046
Echinococcus granulosus hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis Ankyrin 0.0014 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0009 0.0009
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0347 0.0347
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0096 0.0112
Loa Loa (eye worm) cytochrome P450 0.0022 0.0061 0.0061
Echinococcus multilocularis 0.0022 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0173 0.0187
Brugia malayi Uncoordinated protein 44 0.0014 0.002 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0139 0.0151
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0028 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0223 0.0242
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0046 0.0046
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0046 0.005
Schistosoma mansoni topbp1 0.0011 0.0001 0.0001
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0046 0.0046
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0021 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0046 0.005
Echinococcus granulosus glutamate receptor 2 0.0139 0.0709 0.0709
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0046 0.005
Echinococcus granulosus nAChR subunit 0.0012 0.0009 0.0009
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0139 0.0133
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0021 0.0108
Brugia malayi DKFZp564C0469 protein 0.0011 0.0001 0.0001
Echinococcus multilocularis glutamate receptor 2 0.0139 0.0709 0.0709
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0061 0.004
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0125 0.0154
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0001 0.0009
Chlamydia trachomatis DNA ligase 0.0011 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0061 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0088 0.0108
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0046 0.0057
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Brugia malayi Dopamine receptor protein 1 0.0019 0.0046 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0046 0.0046
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0026
Loa Loa (eye worm) doublecortin family protein 0.0041 0.017 0.017
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0061 0.004
Onchocerca volvulus 0.0027 0.0091 0.0621
Schistosoma mansoni hypothetical protein 0.0068 0.0317 0.0343
Onchocerca volvulus 0.0019 0.0046 0.0312
Loa Loa (eye worm) hypothetical protein 0.1817 1 1
Schistosoma mansoni biogenic amine receptor 0.0019 0.0046 0.005
Leishmania major cytochrome p450-like protein 0.0022 0.0061 0.0477
Echinococcus granulosus lamin 0.0027 0.0088 0.0088
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.017 0.017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0133 0.0144
Echinococcus granulosus jun protein 0.0084 0.0404 0.0404
Brugia malayi jmjC domain containing protein 0.0042 0.0173 0.0213
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0046 0.005
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0053 0.0232 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Echinococcus granulosus Ankyrin 0.0014 0.002 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0139 0.1079
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0096 0.0096
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0046 0.005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0046 0.005
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0088
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0046 0.0057
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.024 0.1267 0.8757
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0046 0.0057
Echinococcus granulosus sex peptide receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0125 0.0125
Brugia malayi Cation transporter family protein 0.0012 0.0009 0.0011
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0001 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0123 0.0123
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0061 0.0477
Schistosoma mansoni hypothetical protein 0.0041 0.017 0.0184
Plasmodium falciparum phd finger protein, putative 0.0033 0.0125 0.2109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Onchocerca volvulus 0.0019 0.0046 0.0312
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0084 0.0652
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0322 0.0322
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0223 0.0223
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0028 0.0214
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.003 0.0037
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0139 0.0709 0.0874
Loa Loa (eye worm) hypothetical protein 0.0072 0.0339 0.0339
Echinococcus granulosus allatostatin A receptor 0.0019 0.0046 0.0046
Echinococcus granulosus g protein coupled receptor 0.0019 0.0046 0.0046
Echinococcus granulosus netrin receptor unc 5 0.0014 0.002 0.002
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0061 0.0072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0267 0.0289
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0001 0.0001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0359 0.0359
Loa Loa (eye worm) beta-lactamase 0.0036 0.0139 0.0139
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0009 0.0011
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0021 0.0022
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.003 0.0542
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0046 0.0046
Brugia malayi GnHR receptor homolog 0.0019 0.0046 0.0057
Schistosoma mansoni nAChR subunit 0.0012 0.0009 0.0009
Onchocerca volvulus 0.0012 0.0009 0.0051
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0061 0.004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0139 0.0171
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0136
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0233 0.4224
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0061 0.004
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0346 0.0346
Plasmodium vivax importin-beta 2, putative 0.0022 0.0062 0.1044
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0001 0.00000095829
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0034 0.0129 0.0713
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0019 0.0046 0.0312
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0028 0.0034
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0061 0.0072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.003 0.0231
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0046 0.0046
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0061 0.0072
Echinococcus granulosus atrial natriuretic peptide receptor 0.0139 0.0709 0.0709
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Brugia malayi cytochrome P450 0.0022 0.0061 0.0076
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0001 0.002
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0001 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0139 0.0164
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0164 0.0846 0.0975
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0061 0.0072
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0046 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Onchocerca volvulus 0.0027 0.0088 0.06
Plasmodium vivax SET domain protein, putative 0.0035 0.0133 0.2239
Schistosoma mansoni hypothetical protein 0.0033 0.0125 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Leishmania major GTP-binding protein, putative 0.0016 0.003 0.0231
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0021 0.0021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.0039 0.0211
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0232 0.0286
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0009 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0125 0.0125
Brugia malayi Cytochrome P450 family protein 0.0031 0.0109 0.0135
Schistosoma mansoni smad1 5 8 and 0.0014 0.0017 0.0019
Echinococcus granulosus nibrin 0.0011 0.0001 0.0001
Echinococcus granulosus metabotropic glutamate receptor 2 0.1237 0.6785 0.6785
Brugia malayi sulfakinin receptor protein 0.0019 0.0046 0.0057
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0269 0.0269
Schistosoma mansoni amine GPCR 0.0019 0.0046 0.005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0046 0.0046
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0876 0.6052
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0139 0.0592
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0061 0.004
Echinococcus multilocularis somatostatin receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis nAChR subunit 0.0012 0.0009 0.0009
Schistosoma mansoni ran 0.0016 0.003 0.0032
Loa Loa (eye worm) glutamate receptor 0.0581 0.3155 0.3155
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0046 0.0046
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.0269 0.0269
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0021 0.0021
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Echinococcus multilocularis musashi 0.0027 0.0088 0.0088
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.002 0.0022
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0067
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0046 0.0046
Leishmania major cytochrome p450-like protein 0.0022 0.0061 0.0477
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0235 0.1239 0.1342
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Onchocerca volvulus 0.0019 0.0046 0.0312
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0432 0.2332 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.017 0.017
Treponema pallidum fructose-bisphosphate aldolase 0.0335 0.1794 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0133 0.0144
Schistosoma mansoni loxhd1 0.0041 0.017 0.0184
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0046 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0133 0.0144
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0009 0.0009
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0198 0.0198
Onchocerca volvulus 0.0019 0.0046 0.0312
Onchocerca volvulus 0.0139 0.0709 0.4896
Schistosoma mansoni hypothetical protein 0.024 0.1267 0.1372
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0046 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0054 0.0237 0.0293
Schistosoma mansoni hypothetical protein 0.0022 0.0065 0.007
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0046 0.0312
Leishmania major cytochrome p450-like protein 0.0031 0.0109 0.0849
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0211 0.0228
Onchocerca volvulus 0.0036 0.0139 0.0954
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0061 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0223 0.0223
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0046 0.0046
Schistosoma mansoni smad 0.0014 0.0017 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0009 0.0009
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0036 0.0139 0.1079
Schistosoma mansoni hypothetical protein 0.0169 0.0876 0.0949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0046 0.0046
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Echinococcus granulosus importin subunit beta 1 0.0022 0.0062 0.0062
Schistosoma mansoni opsin-like receptor 0.0019 0.0046 0.005
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0012 0.0009 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0139 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0028 0.0028
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0009 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0217 0.1686
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0061 0.0477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.0072 0.0339 0.0367
Leishmania major hypothetical protein, conserved 0.0244 0.1289 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0046 0.0046
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0248 0.1314 0.1314
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0046 0.0046
Echinococcus multilocularis nibrin 0.0011 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.003 0.0231
Echinococcus multilocularis snurportin 1 0.0235 0.1239 0.1239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.1337 0.7343 0.9053
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0017 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0109 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.024 0.1267 0.1267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0139 0.0133
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0046 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0533 0.2889 0.2889
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0339 0.0418
Brugia malayi AKH receptor 0.0019 0.0046 0.0057
Echinococcus granulosus neuropeptide receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) RGC/RGC protein kinase 0.0139 0.0709 0.0709
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0046 0.005
Onchocerca volvulus 0.0019 0.0046 0.0312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0046 0.005
Onchocerca volvulus 0.0012 0.0009 0.0051
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.0058 0.0058
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0046 0.005
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0046 0.0046
Schistosoma mansoni ran 0.0016 0.003 0.0032
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0028 0.05
Schistosoma mansoni cytochrome P450 0.0022 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) glutamate receptor 0.1476 0.8112 0.8112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0046 0.0046
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0346 0.0426
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0028 0.0464
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0139 0.0709 0.0768
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0009 0.0009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0065 0.0065
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0046 0.005
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0109 0.0109
Echinococcus multilocularis neuropeptide s receptor 0.0533 0.2889 0.2889
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0046 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0125 0.0125
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0009 0.0009
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0129 0.0129
Onchocerca volvulus 0.0019 0.0046 0.0312
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0258 0.1366 0.1366
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0061 0.0072
Brugia malayi hypothetical protein 0.0034 0.0129 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.1289 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis RUN 0.0041 0.017 0.017
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0046 0.0046
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0061 0.0072
Brugia malayi Receptor family ligand binding region containing protein 0.0378 0.2035 0.2509
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0926 0.516
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0404 0.0404
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0173 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0109 0.0849
Brugia malayi hypothetical protein 0.0032 0.0119 0.0147
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0061 0.0072
Brugia malayi AF-10 protein 0.0011 0.0001 0.0001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0335 0.1794 1
Trichomonas vaginalis glucosylceramidase, putative 0.0258 0.1366 0.7614
Schistosoma mansoni opsin-like receptor 0.0019 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0129 0.0129
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0021 0.0021
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.0039 0.0302
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0046 0.0046
Echinococcus granulosus voltage gated potassium channel 0.0021 0.0058 0.0058
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0061 0.1117
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0046 0.0046
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Echinococcus multilocularis jun protein 0.0084 0.0404 0.0404
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0009 0.0011
Echinococcus multilocularis smad 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Trichomonas vaginalis ran, putative 0.0016 0.003 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0046 0.0046
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Entamoeba histolytica hypothetical protein 0.0139 0.0709 0.3947
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0059 0.0269 0.0269
Echinococcus granulosus RUN 0.0041 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0084 0.0463
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0046 0.0046
Schistosoma mansoni biogenic amine receptor 0.0019 0.0046 0.005
Echinococcus granulosus orexin receptor type 2 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1531 0.8415 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0046 0.005
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0001 0.002
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0359 0.2784
Schistosoma mansoni glutamate receptor NMDA 0.0139 0.0709 0.0768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.495 0.495
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.0269 0.0291
Loa Loa (eye worm) hypothetical protein 0.0139 0.0709 0.0709
Schistosoma mansoni neuropeptide receptor 0.0019 0.0046 0.005
Brugia malayi CXXC zinc finger family protein 0.0027 0.0091 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0001 0.00000095829
Toxoplasma gondii HEAT repeat-containing protein 0.0022 0.0062 0.1125
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.002 0.002
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0139 0.0133
Plasmodium falciparum MO15-related protein kinase 0.0118 0.0594 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0084 0.0652
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0046 0.0046
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0046 0.0057
Giardia lamblia PHD finger protein 15 0.0033 0.0125 0.0692
Brugia malayi ORL1-like opioid receptor 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0084 0.0084
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.017 0.2864
Brugia malayi Metabotropic glutamate receptor precursor. 0.1476 0.8112 1
Mycobacterium leprae putative cytochrome p450 0.0022 0.0061 0.0259
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0046 0.0046
Brugia malayi Death domain containing protein 0.0014 0.002 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0045 0.0049
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0058 0.0063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0235 0.1239 0.1239
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0046 0.005
Entamoeba histolytica hypothetical protein 0.0034 0.0129 0.0713
Echinococcus multilocularis cpg binding protein 0.0029 0.0099 0.0099
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0125 0.2274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0359 0.1996
Schistosoma mansoni amine GPCR 0.0019 0.0046 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0139 0.1079
Brugia malayi larval opioid receptor 0.0019 0.0046 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0061 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0139 0.0164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0524 0.0645
Entamoeba histolytica hypothetical protein 0.0034 0.0129 0.0713
Giardia lamblia Fructose-bisphosphate aldolase 0.0335 0.1794 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0009 0.0011
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0061 0.0477
Mycobacterium ulcerans thymidine phosphorylase 0.1531 0.8415 1
Schistosoma mansoni 60S ribosomal protein L21 0.0012 0.0004 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0028 0.0028
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0036 0.0139 0.0133
Brugia malayi G protein-coupled receptor 0.0019 0.0046 0.0057
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0432 0.2332 0.2771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0046 0.005
Echinococcus multilocularis metabotropic glutamate receptor 2 0.1237 0.6785 0.6785
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0876 0.4879
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0009 0.0009
Entamoeba histolytica Ran family GTPase 0.0016 0.003 0.016
Brugia malayi Pre-SET motif family protein 0.0035 0.0133 0.0164
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi PHD-finger family protein 0.0033 0.0125 0.0154
Brugia malayi PHD-finger family protein 0.0012 0.0009 0.0012
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0061 0.0477
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0061 0.0477
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0062 0.048
Echinococcus multilocularis sex peptide receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0335 0.1794 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0133 0.0133
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0061 0.004
Onchocerca volvulus Netrin receptor homolog 0.0014 0.002 0.0128
Brugia malayi hypothetical protein 0.0019 0.0046 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0009 0.0011

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) <= 0.0206 uM Inhibitory concentration against thymidine phosphorylase of Escherichia coli ChEMBL. 15658853
IC50 (binding) <= 0.0206 uM Inhibitory concentration against thymidine phosphorylase of Escherichia coli ChEMBL. 15658853
IC50 (binding) = 0.049 uM Inhibitory concentration against human thymidine phosphorylase ChEMBL. 15658853
IC50 (binding) = 0.049 uM Inhibitory concentration against human thymidine phosphorylase ChEMBL. 15658853

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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