Detailed information for compound 371776

Basic information

Technical information
  • TDR Targets ID: 371776
  • Name: 9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-2,9-d ihydro-1H-fluoren-3-one
  • MW: 382.451 | Formula: C26H22O3
  • H donors: 2 H acceptors: 3 LogP: 4.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)CC1(C2=C(C(=O)CC1)c1ccc(cc1)O)Cc1ccccc1
  • InChi: 1S/C26H22O3/c27-20-8-6-18(7-9-20)24-23(29)12-13-26(15-17-4-2-1-3-5-17)16-19-14-21(28)10-11-22(19)25(24)26/h1-11,14,27-28H,12-13,15-16H2
  • InChiKey: PLRCLQGHUZGZQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-hydroxy-4-(4-hydroxyphenyl)-9a-(phenylmethyl)-2,9-dihydro-1H-fluoren-3-one
  • 9a-(benzyl)-7-hydroxy-4-(4-hydroxyphenyl)-2,9-dihydro-1H-fluoren-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 2 (ER beta) Starlite/ChEMBL References
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0269 0.0319 0.1355
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0242 0.0238 0.0993
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0271 0.0327 0.0847
Echinococcus granulosus fibroblast growth factor receptor 4 0.081 0.199 0.1984
Echinococcus multilocularis titin 0.0204 0.0119 0.0145
Plasmodium vivax tyrosine kinase-like protein, putative 0.0208 0.0133 0.0414
Brugia malayi phosphoinositide-dependent protein kinase I 0.0261 0.0294 0.0312
Brugia malayi Protein kinase domain containing protein 0.0696 0.164 0.1774
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0278 0.0347 0.0422
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Onchocerca volvulus 0.0269 0.0319 0.0394
Schistosoma mansoni tyrosine kinase 0.0427 0.0809 0.1397
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Trypanosoma brucei SNF1-related protein kinases, putative 0.0251 0.0266 0.0334
Loa Loa (eye worm) hypothetical protein 0.03 0.0414 0.0443
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Brugia malayi Protein kinase domain containing protein 0.136 0.3688 0.4
Brugia malayi Pleckstrin Homology Domain 0.0183 0.0055 0.0052
Echinococcus granulosus tyrosine protein kinase 0.0696 0.164 0.1634
Trypanosoma brucei cdc2-related kinase 1 0.0386 0.0681 0.1506
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Brugia malayi intracellular kinase 0.0419 0.0783 0.0843
Echinococcus multilocularis activin receptor type 0.0242 0.0238 0.0289
Plasmodium falciparum casein kinase 1 0.0312 0.0452 0.1886
Schistosoma mansoni serine/threonine protein kinase 0.0661 0.1531 0.2645
Echinococcus granulosus serine:threonine kinase SAD 1 0.0251 0.0266 0.0259
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0261 0.0294 0.0357
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus twitchin 0.0437 0.0839 0.0833
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0168 0.0007 0.0008
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Giardia lamblia Kinase, STE STE20 0.0276 0.0341 0.092
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0308 0.0439 0.1152
Echinococcus granulosus rho-associated protein kinase 1 0.1078 0.2818 0.2813
Echinococcus multilocularis N chimaerin 0.0295 0.0401 0.0487
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0265 0.0309 0.0328
Loa Loa (eye worm) CAMK protein kinase 0.0204 0.0119 0.0122
Loa Loa (eye worm) TK/ABL protein kinase 0.1004 0.2588 0.2805
Trichomonas vaginalis CAMK family protein kinase 0.0411 0.0759 0.2024
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0419 0.0783 0.3433
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Trichomonas vaginalis STE family protein kinase 0.0271 0.0327 0.0847
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0714 0.1234
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus multilocularis tyrosine protein kinase Blk 0.0572 0.1255 0.1523
Echinococcus granulosus tyrosine protein kinase Srms 0.1246 0.3336 0.3331
Brugia malayi Protein kinase domain 0.0276 0.0341 0.0363
Echinococcus multilocularis mitogen activated protein kinase 0.0268 0.0317 0.0385
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0692 0.1625 0.1972
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0894 0.225 0.3886
Brugia malayi Temporarily assigned gene name protein 59 0.0269 0.0319 0.0339
Schistosoma mansoni tyrosine kinase 0.1309 0.3532 0.6101
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0757 0.1827 0.1822
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.0375 0.0977
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0332 0.0513 0.0623
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0475 0.0957 0.1162
Echinococcus multilocularis calcium activated potassium channel 0.0397 0.0714 0.0867
Echinococcus granulosus CDC7 cell division cycle 7 0.0229 0.0195 0.0188
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0171 0.0016 0.001
Brugia malayi Casein kinase II, alpha chain 0.0323 0.0487 0.0522
Echinococcus granulosus cyclin dependent kinase 0.0386 0.0681 0.0674
Onchocerca volvulus 0.0466 0.0927 0.1598
Schistosoma mansoni protein kinase 0.0475 0.0957 0.1653
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0659 0.1525 0.1851
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0171 0.0016 0.0009
Plasmodium falciparum protein serine/threonine kinase-1 0.0376 0.0649 0.3045
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0269 0.0319 0.0387
Loa Loa (eye worm) hypothetical protein 0.0269 0.0319 0.0339
Onchocerca volvulus 0.0308 0.0439 0.0633
Echinococcus granulosus mitogen activated protein kinase 14 0.0521 0.1098 0.1092
Brugia malayi Protein kinase domain containing protein 0.0308 0.0439 0.047
Loa Loa (eye worm) TK/KIN16 protein kinase 0.2108 0.5996 0.651
Brugia malayi Protein kinase c protein 2 0.0367 0.0624 0.0671
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0371 0.0633 0.3246
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.065 0.1495 0.2582
Schistosoma mansoni protein kinase 0.0877 0.2198 0.3797
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0419 0.0783 0.0843
Echinococcus multilocularis insulin receptor 0.1495 0.4105 0.4983
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0714 0.1234
Echinococcus granulosus mitogen activated protein kinase 11 0.0521 0.1098 0.1092
Brugia malayi Protein kinase domain containing protein 0.0629 0.1432 0.1549
Schistosoma mansoni tyrosine kinase 0.1342 0.3633 0.6275
Echinococcus granulosus casein kinase i 0.0312 0.0452 0.0446
Trypanosoma cruzi polo-like protein kinase, putative 0.0894 0.225 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0766 0.1854 0.2008
Giardia lamblia Kinase, PLK 0.0894 0.225 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0692 0.1625 0.1619
Loa Loa (eye worm) hypothetical protein 0.0278 0.0347 0.037
Entamoeba histolytica protein kinase, putative 0.0261 0.0294 0.0758
Brugia malayi Protein kinase domain containing protein 0.1495 0.4105 0.4454
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1403 0.382 0.4144
Loa Loa (eye worm) hypothetical protein 0.0399 0.0722 0.0777
Brugia malayi Immunoglobulin I-set domain containing protein 0.031 0.0447 0.0479
Brugia malayi Tyrosine-protein kinase abl-1 0.0693 0.163 0.1764
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0225 0.0184 0.0177
Loa Loa (eye worm) hypothetical protein 0.0401 0.0727 0.0782
Echinococcus multilocularis 0.0278 0.0347 0.0421
Schistosoma mansoni serine/threonine kinase 0.065 0.1495 0.2582
Echinococcus granulosus raf serine:threonine protein kinase 0.0277 0.0345 0.0338
Loa Loa (eye worm) TK/FER protein kinase 0.1006 0.2595 0.2813
Giardia lamblia Kinase, CAMK CAMKL 0.0251 0.0266 0.0562
Entamoeba histolytica casein kinase, putative 0.0323 0.0487 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus serine:threonine protein kinase 0.037 0.0632 0.0626
Loa Loa (eye worm) AGC/AKT protein kinase 0.136 0.3688 0.4
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0645 0.148 0.1601
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0278 0.0347 0.0631
Trypanosoma cruzi cdc2-related kinase 3 0.0386 0.0681 0.2975
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0521 0.1098 0.2686
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.0345 0.0595
Echinococcus granulosus tyrosine protein kinase HCK 0.0409 0.0752 0.0746
Schistosoma mansoni tyrosine kinase 0.081 0.199 0.3437
Entamoeba histolytica PH domain containing protein kinase, putative 0.0808 0.1984 0.536
Leishmania major protein kinase A catalytic subunit isoform 2 0.0371 0.0633 0.231
Entamoeba histolytica protein kinase, putative 0.0397 0.0716 0.1907
Schistosoma mansoni tyrosine kinase 0.1197 0.3186 0.5504
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0766 0.1854 0.2008
Loa Loa (eye worm) hypothetical protein 0.0269 0.0319 0.0339
Echinococcus multilocularis mitogen activated protein kinase 14 0.0521 0.1098 0.1333
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0312 0.0452 0.1953
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0521 0.1098 0.4845
Echinococcus multilocularis cyclin dependent kinase 1 0.0386 0.0681 0.0826
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1006 0.2595 0.3149
Echinococcus multilocularis casein kinase I delta 0.0312 0.0452 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0786 0.1916 0.331
Schistosoma mansoni adapter molecule crk 0.0283 0.0362 0.0626
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.0681 0.181
Loa Loa (eye worm) hypothetical protein 0.0411 0.0758 0.0816
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0212 0.0145 0.0176
Loa Loa (eye worm) TK/EPH protein kinase 0.0418 0.0781 0.0841
Trichomonas vaginalis STE family protein kinase 0.0444 0.086 0.23
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0769
Schistosoma mansoni protein kinase 0.1044 0.2714 0.4688
Loa Loa (eye worm) hypothetical protein 0.0283 0.0362 0.0386
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0894 0.225 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0278 0.0347 0.1266
Echinococcus multilocularis Immunoglobulin 0.0272 0.0328 0.0399
Loa Loa (eye worm) TK/ROR protein kinase 0.0212 0.0145 0.015
Loa Loa (eye worm) CDC7 protein kinase 0.0229 0.0195 0.0204
Echinococcus granulosus aurora kinase A 0.0475 0.0957 0.0951
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1534 0.4224 0.422
Schistosoma mansoni protein kinase 0.0276 0.0341 0.0589
Brugia malayi serine/threonine-protein kinase plk-2 0.0894 0.225 0.2438
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0171 0.0016 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0586 0.1298 0.1403
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0283 0.0362 0.0386
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0764 0.1849 0.1843
Echinococcus granulosus cyclin dependent kinase 5 0.0386 0.0681 0.0674
Entamoeba histolytica protein kinase, putative 0.0282 0.036 0.0938
Onchocerca volvulus 0.0215 0.0153 0.0066
Toxoplasma gondii casein kinase I 0.0312 0.0452 0.0941
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0213 0.0148 0.0589
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0242 0.0238 0.0309
Trichomonas vaginalis CK1 family protein kinase 0.0312 0.0452 0.1188
Echinococcus multilocularis serine:threonine protein kinase N2 0.0298 0.0411 0.0498
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Giardia lamblia Kinase, NEK 0.0444 0.086 0.339
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0849 0.2111 0.2286
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0276 0.0341 0.0334
Brugia malayi ephrin receptor 1 precursor 0.0246 0.0249 0.0263
Loa Loa (eye worm) hypothetical protein 0.0371 0.0633 0.0681
Loa Loa (eye worm) hypothetical protein 0.0288 0.0379 0.0404
Echinococcus multilocularis tyrosine protein kinase 0.0696 0.164 0.199
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0419 0.0783 0.0777
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1006 0.2595 0.259
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0268 0.0317 0.1349
Schistosoma mansoni serine/threonine protein kinase 0.0342 0.0545 0.0941
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus multilocularis roundabout 2 0.0168 0.0007 0.0008
Toxoplasma gondii AGC kinase 0.1309 0.3531 1
Schistosoma mansoni protein kinase 0.0466 0.0927 0.1601
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0419 0.0783 0.3022
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Brugia malayi Kinase associated domain 1 family protein 0.0299 0.0412 0.0441
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1403 0.382 0.4144
Trichomonas vaginalis AGC family protein kinase 0.065 0.1495 0.4028
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0475 0.0957 0.2563
Echinococcus multilocularis casein kinase i 0.0312 0.0452 0.0549
Echinococcus multilocularis serine:threonine protein kinase 3 0.0849 0.2111 0.2562
Brugia malayi Protein kinase domain containing protein 0.04 0.0723 0.0778
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0268 0.0317 0.1349
Loa Loa (eye worm) AUR protein kinase 0.0475 0.0957 0.1033
Loa Loa (eye worm) hypothetical protein 0.0547 0.1178 0.1273
Brugia malayi Tyrosine-protein kinase abl-1 0.043 0.0817 0.088
Entamoeba histolytica PH domain containing protein kinase, putative 0.0421 0.079 0.2109
Schistosoma mansoni protein kinase 0.0374 0.0645 0.1115
Leishmania major protein kinase, putative 0.0278 0.0347 0.095
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Entamoeba histolytica protein kinase, putative 0.0225 0.0184 0.0457
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0488 0.0997 0.1076
Brugia malayi Immunoglobulin I-set domain containing protein 0.2108 0.5996 0.651
Trypanosoma cruzi casein kinase, putative 0.0312 0.0452 0.1953
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0957 0.2563
Echinococcus multilocularis growth factor receptor bound protein 2 0.0283 0.0362 0.044
Brugia malayi Hr1 repeat family protein 0.0948 0.2416 0.2618
Plasmodium falciparum glycogen synthase kinase 3 0.0419 0.0783 0.3837
Echinococcus multilocularis nervana 2 0.0659 0.1525 0.1851
Echinococcus granulosus NCK adaptor protein 0.0283 0.0362 0.0356
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0374 0.0645 0.0694
Echinococcus multilocularis 0.0374 0.0645 0.0783
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0521 0.1098 0.1186
Brugia malayi Protein kinase domain containing protein 0.0213 0.0148 0.0153
Echinococcus granulosus mitogen activated protein kinase 0.0268 0.0317 0.0311
Giardia lamblia Kinase, NEK 0.0444 0.086 0.339
Echinococcus granulosus activin receptor type 0.0242 0.0238 0.0231
Echinococcus granulosus casein kinase ii subunit alpha 0.0323 0.0487 0.0481
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0251 0.0266 0.1167
Entamoeba histolytica serine/threonine protein kinase, putative 0.0251 0.0266 0.068
Echinococcus multilocularis neuroglian 0.0168 0.0007 0.0008
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0371 0.0633 0.1372
Giardia lamblia Kinase, AGC PKA 0.0757 0.1827 0.7989
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Brugia malayi hypothetical protein 0.0269 0.0319 0.0339
Schistosoma mansoni nephrin 0.0378 0.0656 0.1133
Schistosoma mansoni serine/threonine protein kinase 0.0513 0.1072 0.1852
Brugia malayi Protein kinase domain containing protein 0.1323 0.3575 0.3878
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0877 0.2198 0.2193
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.0452 0.0781
Brugia malayi Protein kinase domain containing protein 0.0697 0.164 0.1775
Echinococcus multilocularis casein kinase I alpha 0.0312 0.0452 0.0549
Entamoeba histolytica protein kinase, putative 0.0419 0.0783 0.2089
Echinococcus multilocularis rho associated protein kinase 0.1078 0.2818 0.3421
Trichomonas vaginalis CMGC family protein kinase 0.0419 0.0783 0.2089
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0276 0.0341 0.0334
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0932 0.2366 0.2361
Schistosoma mansoni neuroglian 0.0168 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0545 0.1173 0.1267
Giardia lamblia Kinase, NEK 0.0444 0.086 0.339
Trypanosoma cruzi cdc2-related kinase 3 0.0386 0.0681 0.2975
Loa Loa (eye worm) hypothetical protein 0.0598 0.1335 0.1444
Trichomonas vaginalis AGC family protein kinase 0.0747 0.1797 0.4851
Giardia lamblia Kinase, AGC PKA 0.0371 0.0633 0.231
Schistosoma mansoni hypothetical protein 0.0269 0.0319 0.055
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0545 0.1173 0.1167
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Schistosoma mansoni cell adhesion molecule 0.0168 0.0007 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0225 0.0184 0.0223
Echinococcus granulosus N chimaerin 0.0295 0.0401 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0609 0.1369 0.2365
Schistosoma mansoni tyrosine kinase 0.0692 0.1625 0.2806
Trichomonas vaginalis CMGC family protein kinase 0.0229 0.0195 0.0487
Trichomonas vaginalis STE family protein kinase 0.0203 0.0116 0.0273
Brugia malayi hypothetical protein 0.0308 0.0439 0.047
Echinococcus granulosus protein kinase c iota type 0.106 0.2762 0.2757
Brugia malayi Protein kinase domain containing protein 0.1002 0.2582 0.2799
Schistosoma mansoni growth factor receptor-bound protein 0.0283 0.0362 0.0626
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0213 0.0148 0.0153
Trichomonas vaginalis AGC family protein kinase 0.0697 0.164 0.4423
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0633 0.1094
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1342 0.3633 0.3629
Echinococcus granulosus titin 0.0204 0.0119 0.0112
Echinococcus granulosus protein tyrosine kinase 0.1309 0.3532 0.3528
Echinococcus multilocularis neuroglian 0.0339 0.0537 0.0652
Entamoeba histolytica casein kinase, putative 0.0312 0.0452 0.1188
Trichomonas vaginalis CMGC family protein kinase 0.0229 0.0195 0.0487
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0371 0.0633 0.1372
Echinococcus multilocularis Glutaredoxin protein 5 0.0659 0.1525 0.1851
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0397 0.0716 0.0771
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0533 0.1136 0.1962
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0214 0.015 0.0602
Echinococcus multilocularis protein kinase c epsilon type 0.0786 0.1916 0.2326
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.0317 0.0821
Schistosoma mansoni ephrin receptor 0.0359 0.0599 0.1035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0894 0.225 0.2245
Giardia lamblia Kinase, STE STE20 0.0271 0.0327 0.0853
Brugia malayi protein-tyrosine kinase 0.0572 0.1255 0.1356
Echinococcus multilocularis protein kinase shaggy 0.0419 0.0783 0.095
Loa Loa (eye worm) SRC-1 0.0692 0.1625 0.1758
Plasmodium vivax calcium-dependent protein kinase, putative 0.0278 0.0347 0.1628
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0957 0.2563
Echinococcus granulosus expressed protein 0.0213 0.0148 0.0141
Entamoeba histolytica protein kinase, putative 0.0475 0.0957 0.2563
Schistosoma mansoni kinase 0.0956 0.2441 0.4216
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0661 0.1529 0.1524
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.1054 0.2744 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0669 0.1555 0.2686
Trypanosoma brucei cdc2-related kinase 3 0.0386 0.0681 0.1506
Loa Loa (eye worm) hypothetical protein 0.1115 0.2932 0.318
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Entamoeba histolytica protein kinase, putative 0.1309 0.3531 0.9572
Brugia malayi Protein kinase domain containing protein 0.0308 0.0439 0.047
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0342 0.0545 0.0584
Leishmania major protein kinase, putative 0.0376 0.0649 0.2384
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0225 0.0184 0.0223
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0272 0.0328 0.0567
Schistosoma mansoni cell adhesion molecule 0.0168 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0178 0.0039 0.0035
Brugia malayi putative serine/threonine kinase SADA gamma 0.0251 0.0266 0.0282
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0767 0.1856 0.201
Leishmania major protein kinase, putative 0.0376 0.0649 0.2384
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0251 0.0266 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0575 0.1264 0.2184
Schistosoma mansoni cell adhesion molecule 0.0372 0.0637 0.11
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0427 0.0809 0.1397
Trichomonas vaginalis AGC family protein kinase 0.0697 0.164 0.4423
Brugia malayi Variant SH3 domain containing protein 0.0295 0.0401 0.0428
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0919 0.2327 0.2825
Echinococcus granulosus epidermal growth factor receptor 0.1342 0.3633 0.3629
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0168 0.0007 0.0008
Echinococcus multilocularis calcium dependent protein kinase 0.018 0.0045 0.0055
Echinococcus multilocularis dual specificity 0.0397 0.0716 0.0869
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0342 0.0545 0.0584
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.0681 0.181
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Loa Loa (eye worm) hypothetical protein 0.0482 0.0977 0.1054
Onchocerca volvulus 0.0308 0.0439 0.0633
Onchocerca volvulus 0.0224 0.0182 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.0148 0.0255
Entamoeba histolytica PH domain containing protein kinase, putative 0.0808 0.1984 0.536
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0272 0.0328 0.0567
Plasmodium falciparum serine/threonine protein kinase, putative 0.0475 0.0957 0.4865
Brugia malayi Protein kinase domain containing protein 0.0397 0.0716 0.0771
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0272 0.0328 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0376 0.0649 0.1416
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0276 0.0341 0.0414
Loa Loa (eye worm) hypothetical protein 0.0598 0.1336 0.1444
Schistosoma mansoni serine/threonine-protein kinase 0.0808 0.1984 0.3427
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0386 0.0681 0.0674
Trichomonas vaginalis CAMK family protein kinase 0.0278 0.0347 0.0902
Trichomonas vaginalis AGC family protein kinase 0.0444 0.086 0.23
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0874 0.2188 0.2655
Schistosoma mansoni nck2/grb4 0.0283 0.0362 0.0626
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0894 0.225 0.2438
Giardia lamblia Kinase, CMGC GSK 0.0419 0.0783 0.3022
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0366 0.0621 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.0039 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0586 0.1298 0.3491
Trichomonas vaginalis AGC family protein kinase 0.0261 0.0294 0.0757
Schistosoma mansoni vesicular amine transporter 0.0272 0.0328 0.0567
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0269 0.0319 0.1355
Trypanosoma cruzi cdc2-related kinase 1 0.0386 0.0681 0.2975
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0786 0.1916 0.2075
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0312 0.0452 0.0484
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0268 0.0317 0.1349
Entamoeba histolytica protein kinase domain containing protein 0.0323 0.0487 0.1283
Giardia lamblia Kinase, CMGC MAPK 0.0268 0.0317 0.0807
Echinococcus granulosus tyrosine protein kinase Src42A 0.0432 0.0822 0.0816
Plasmodium falciparum casein kinase 2, alpha subunit 0.0323 0.0487 0.2091
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0273 0.0331 0.0402
Trichomonas vaginalis AGC family protein kinase 0.0261 0.0294 0.0757
Echinococcus multilocularis protein kinase c iota type 0.106 0.2762 0.3353
Giardia lamblia Kinase, CMGC DYRK 0.0342 0.0545 0.1888
Brugia malayi SH2 domain containing protein 0.1006 0.2595 0.2813
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Echinococcus multilocularis roundabout 2 0.0439 0.0846 0.1026
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0266 0.0459
Schistosoma mansoni protein kinase 0.1044 0.2714 0.4688
Leishmania major protein kinase A catalytic subunit isoform 1 0.0371 0.0633 0.231
Toxoplasma gondii AGC kinase 0.0371 0.0633 0.1473
Echinococcus multilocularis protein tyrosine kinase 0.1309 0.3532 0.4287
Onchocerca volvulus 0.0415 0.077 0.1287
Loa Loa (eye worm) TK protein kinase 0.0696 0.164 0.1774
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0521 0.1098 0.4523
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0266 0.0459
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0386 0.0681 0.2536
Trichomonas vaginalis CMGC family protein kinase 0.0419 0.0783 0.2089
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0171 0.0016 0.001
Echinococcus granulosus cGMP dependent protein kinase 1 0.0332 0.0513 0.0507
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0242 0.0238 0.0255
Loa Loa (eye worm) hypothetical protein 0.0861 0.2148 0.2327
Echinococcus granulosus serine threonine protein kinase nrc 0.0757 0.1827 0.1822
Loa Loa (eye worm) hypothetical protein 0.0552 0.1193 0.1289
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0278 0.0347 0.1628
Echinococcus multilocularis casein kinase I delta 0.0312 0.0452 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0661 0.1531 0.2645
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0692 0.1625 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.1078 0.2818 0.4868
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0171 0.0016 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Brugia malayi Protein kinase domain containing protein 0.0513 0.1072 0.1158
Plasmodium falciparum calcium-dependent protein kinase 1 0.0278 0.0347 0.1266
Loa Loa (eye worm) AGC/PKG protein kinase 0.0332 0.0513 0.0551
Schistosoma mansoni vam6/vps39 related 0.0269 0.0319 0.055
Loa Loa (eye worm) hypothetical protein 0.1062 0.2768 0.3001
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0431 0.082 0.3197
Brugia malayi Protein kinase domain containing protein 0.0308 0.0439 0.047
Echinococcus multilocularis tyrosine kinase 0.0308 0.0439 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0716 0.1237
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.0317 0.0821
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0376 0.0649 0.2833
Echinococcus granulosus serine:threonine protein kinase N2 0.0298 0.0411 0.0404
Loa Loa (eye worm) TK protein kinase 0.0878 0.2199 0.2382
Trichomonas vaginalis STE family protein kinase 0.0276 0.0341 0.0885
Echinococcus granulosus protein kinase 0.0374 0.0645 0.0639
Plasmodium falciparum calcium-dependent protein kinase 4 0.0278 0.0347 0.1266
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.131 0.3534 0.4289
Echinococcus granulosus tyrosine protein kinase Src42A 0.0692 0.1625 0.1619
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1044 0.2714 0.2709
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1004 0.2588 0.3141
Trypanosoma cruzi casein kinase, putative 0.0312 0.0452 0.1953
Onchocerca volvulus 0.163 0.4521 0.8705
Giardia lamblia Kinase, CMGC CLK 0.0376 0.0649 0.2384
Loa Loa (eye worm) TK/EGFR protein kinase 0.2041 0.5789 0.6285
Loa Loa (eye worm) TK protein kinase 0.0409 0.0752 0.081
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0419 0.0783 0.1352
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0575 0.1264 0.1258
Brugia malayi protein unc-22 0.0204 0.0119 0.0122
Brugia malayi SRC-1 0.0692 0.1625 0.1758
Echinococcus multilocularis cyclin dependent kinase 5 0.0386 0.0681 0.0826
Echinococcus granulosus serine:threonine protein kinase N2 0.0948 0.2416 0.2411
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1044 0.2714 0.3294
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.131 0.3534 0.3833
Entamoeba histolytica protein kinase, putative 0.0409 0.0752 0.2004
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1002 0.2582 0.2577
Schistosoma mansoni tyrosine kinase 0.0799 0.1956 0.3379
Echinococcus multilocularis serine:threonine protein kinase N2 0.065 0.1495 0.1814
Schistosoma mansoni tyrosine kinase 0.1197 0.3186 0.5504
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.0649 0.1121
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0278 0.0347 0.0422
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0838 0.2076 0.2249
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0268 0.0317 0.0807
Brugia malayi Protein kinase domain containing protein 0.0261 0.0294 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Schistosoma mansoni tyrosine kinase 0.0692 0.1625 0.2806
Toxoplasma gondii histone kinase SNF1, putative 0.0251 0.0266 0.0392
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0278 0.0347 0.0631
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0376 0.0649 0.1519
Schistosoma mansoni tyrosine kinase 0.1495 0.4105 0.7091
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1182 0.3138 0.3133
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0444 0.086 0.2141
Echinococcus multilocularis myotubularin protein 13 0.0183 0.0055 0.0067
Schistosoma mansoni serine/threonine kinase 0.0586 0.1298 0.2242
Echinococcus multilocularis mitogen activated protein kinase 3 0.0268 0.0317 0.0385
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0533 0.1136 0.1227
Onchocerca volvulus 0.098 0.2516 0.474
Brugia malayi Protein kinase domain containing protein 0.0877 0.2198 0.2382
Brugia malayi ribosomal protein S6 kinase alpha 3 0.038 0.0663 0.0713
Echinococcus multilocularis epidermal growth factor receptor 0.2041 0.5789 0.7027
Toxoplasma gondii AGC kinase 0.0371 0.0633 0.1473
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0661 0.1531 0.1859
Loa Loa (eye worm) hypothetical protein 0.0466 0.0927 0.1
Leishmania major protein kinase A catalytic subunit 0.0371 0.0633 0.231
Echinococcus granulosus serine:threonine protein kinase 0.037 0.0632 0.0626
Brugia malayi MAP kinase sur-1 0.0268 0.0317 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0268 0.0317 0.0548
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1245 0.3333 0.3615
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0659 0.1525 0.1519
Echinococcus granulosus cGMP dependent protein kinase 0.0332 0.0513 0.0507
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0376 0.0649 0.0698
Brugia malayi Protein kinase domain containing protein 0.1403 0.382 0.4144
Schistosoma mansoni ste20-related kinase 0.0676 0.1575 0.272
Echinococcus multilocularis NCK adaptor protein 0.0287 0.0376 0.0457
Echinococcus granulosus protein kinase C gamma type 0.0787 0.1919 0.1913
Giardia lamblia Kinase, CMGC CK2 0.0323 0.0487 0.1615
Trichomonas vaginalis CMGC family protein kinase 0.0376 0.0649 0.1723
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.0375 0.0977
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0371 0.0633 0.2954
Echinococcus multilocularis expressed protein 0.0213 0.0148 0.0179
Brugia malayi Egg laying defective protein 4 0.0332 0.0513 0.0551
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0278 0.0347 0.1628
Onchocerca volvulus 0.0229 0.0195 0.015
Schistosoma mansoni tyrosine kinase 0.1197 0.3186 0.5504
Echinococcus granulosus serine:threonine protein kinase 3 0.0849 0.2111 0.2105
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0692 0.1625 0.1619
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0366 0.0621 0.0614
Loa Loa (eye worm) hypothetical protein 0.037 0.0632 0.068
Brugia malayi serine/threonine kinase 12 0.0475 0.0957 0.1033
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1002 0.2582 0.2799
Brugia malayi Variant SH3 domain containing protein 0.0218 0.0163 0.0169
Echinococcus granulosus casein kinase I alpha 0.0312 0.0452 0.0446
Plasmodium falciparum protein kinase 5 0.0386 0.0681 0.3234
Trypanosoma brucei protein kinase, putative 0.0242 0.0238 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0016 0.0028
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0397 0.0716 0.3135
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0397 0.0716 0.1606
Loa Loa (eye worm) AGC/PKN protein kinase 0.0948 0.2416 0.2618
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.1309 0.3531 0.383
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0342 0.0545 0.1121
Echinococcus granulosus casein kinase I gamma 0.0513 0.1072 0.1066
Entamoeba histolytica protein kinase, putative 0.0203 0.0116 0.0273
Echinococcus multilocularis tyrosine protein kinase Abl 0.0693 0.163 0.1979
Schistosoma mansoni tyrosine kinase 0.1495 0.4105 0.7091
Mycobacterium ulcerans hypothetical protein 0.0234 0.0212 0.5
Giardia lamblia Kinase, CDC7 0.0229 0.0195 0.0225
Schistosoma mansoni protein kinase 0.0764 0.1849 0.3193
Onchocerca volvulus 0.0419 0.0783 0.1312
Echinococcus granulosus hypothetical protein 0.0278 0.0347 0.034
Brugia malayi Protein kinase domain containing protein 0.0689 0.1617 0.175
Brugia malayi Stress-activated protein kinase jnk-1 0.0874 0.2188 0.237
Schistosoma mansoni growth factor receptor-bound protein 0.0287 0.0376 0.065
Brugia malayi hypothetical protein 0.0533 0.1136 0.1227
Schistosoma mansoni protein kinase 0.0312 0.0452 0.0781
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0295 0.0401 0.0395
Trypanosoma cruzi casein kinase, putative 0.0312 0.0452 0.1953
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0633 0.1094
Schistosoma mansoni serine/threonine protein kinase 0.037 0.0631 0.1089
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0196 0.0094 0.0211
Schistosoma mansoni serine/threonine-protein kinase 0.0808 0.1984 0.3427
Schistosoma mansoni protein kinase 0.1044 0.2714 0.4688
Schistosoma mansoni tyrosine kinase 0.1067 0.2783 0.4807
Loa Loa (eye worm) hypothetical protein 0.0278 0.0347 0.037
Echinococcus multilocularis serine:threonine protein kinase 0.037 0.0632 0.0767
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1002 0.2582 0.3134
Loa Loa (eye worm) AUR protein kinase 0.0475 0.0957 0.1033
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0278 0.0347 0.037
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0323 0.0487 0.0522
Echinococcus granulosus dual specificity 0.0397 0.0716 0.071
Toxoplasma gondii aurora kinase 0.0475 0.0957 0.2426
Loa Loa (eye worm) hypothetical protein 0.0415 0.077 0.0829
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0261 0.0294 0.0758
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0386 0.0681 0.1613
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0278 0.0347 0.0341
Echinococcus multilocularis cyclin dependent kinase 0.0386 0.0681 0.0826
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0533 0.1136 0.113
Onchocerca volvulus Serine\/threonine kinase homolog 0.04 0.0723 0.1194
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.0681 0.1176
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0386 0.0681 0.0732
Brugia malayi Protein kinase domain containing protein 0.0308 0.0439 0.047
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0261 0.0294 0.0287
Echinococcus multilocularis dual specificity 0.0342 0.0545 0.0661
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0529 0.1122 0.1212
Entamoeba histolytica protein kinase domain containing protein 0.0342 0.0545 0.144
Loa Loa (eye worm) AUR protein kinase 0.0475 0.0957 0.1033
Echinococcus multilocularis 0.0583 0.1289 0.1564
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0342 0.0545 0.2366
Entamoeba histolytica protein kinase , putative 0.0475 0.0957 0.2563
Entamoeba histolytica PH domain containing protein kinase, putative 0.0421 0.079 0.2109
Echinococcus granulosus dual specificity 0.0342 0.0545 0.0538
Entamoeba histolytica protein kinase, putative 0.0225 0.0184 0.0457
Entamoeba histolytica protein kinase, putative 0.0342 0.0545 0.144
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0278 0.0347 0.037
Entamoeba histolytica protein kinase domain containing protein 0.0488 0.0997 0.2671
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0661 0.1529 0.1856
Brugia malayi Protein kinase domain containing protein 0.0386 0.0681 0.0732
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0371 0.0633 0.2763
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0513 0.1072 0.1157
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.0347 0.06
Leishmania major protein kinase, putative 0.0242 0.0238 0.0429
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.065 0.1495 0.1814
Echinococcus granulosus dual specificity 0.0342 0.0545 0.0538
Loa Loa (eye worm) AGC/PKA protein kinase 0.0371 0.0633 0.0681
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0268 0.0317 0.0807
Onchocerca volvulus 0.0308 0.0439 0.0633
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0261 0.0294 0.0312
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0475 0.0957 0.2563
Brugia malayi hypothetical protein 0.031 0.0447 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.0669 0.1555 0.2686
Echinococcus granulosus tyrosine protein kinase Lyn 0.0789 0.1926 0.1921
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Brugia malayi Sex muscle abnormal protein 5 0.0283 0.0362 0.0386
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Echinococcus multilocularis roundabout 2 0.0168 0.0007 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0521 0.1098 0.4845
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0627
Echinococcus granulosus insulin receptor 0.1495 0.4105 0.4101
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0332 0.0513 0.112
Echinococcus granulosus casein kinase I delta 0.0312 0.0452 0.0446
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Entamoeba histolytica protein kinase 2, putative 0.0757 0.1827 0.4933
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Trichomonas vaginalis STE family protein kinase 0.0276 0.0341 0.0885
Echinococcus multilocularis casein kinase ii subunit alpha 0.0323 0.0487 0.0591
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0757 0.1827 0.8108
Brugia malayi Protein kinase domain containing protein 0.037 0.0632 0.068
Echinococcus granulosus neuroglian 0.0339 0.0537 0.0531
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0184 0.0318
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.081 0.199 0.2415
Echinococcus granulosus Vam6:Vps39 protein 0.0269 0.0319 0.0312
Loa Loa (eye worm) thyroid receptor interactor 0.0294 0.0398 0.0425
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0419 0.0783 0.095
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0278 0.0347 0.0341
Loa Loa (eye worm) hypothetical protein 0.0273 0.0331 0.0353
Loa Loa (eye worm) hypothetical protein 0.0401 0.0727 0.0782
Echinococcus multilocularis myosin iiia 0.0271 0.0327 0.0397
Echinococcus multilocularis death associated protein kinase 1 0.2834 0.8239 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0269 0.0319 0.055
Echinococcus multilocularis serine:threonine protein kinase N2 0.0948 0.2416 0.2933
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0432 0.0822 0.0998
Echinococcus granulosus casein kinase I alpha 0.0312 0.0452 0.0446
Loa Loa (eye worm) hypothetical protein 0.0272 0.0328 0.0349
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus granulosus Immunoglobulin 0.0272 0.0328 0.0322
Schistosoma mansoni titin 0.0204 0.0119 0.0206
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1002 0.2582 0.2799
Trypanosoma brucei rac serine-threonine kinase, putative 0.136 0.3688 1
Echinococcus granulosus calcium dependent protein kinase 0.018 0.0045 0.0039
Brugia malayi map kinase activated protein kinase protein 2 0.131 0.3534 0.3833
Onchocerca volvulus 0.0547 0.1178 0.2095
Echinococcus multilocularis ephrin type A receptor 4 A 0.0359 0.0599 0.0727
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0278 0.0347 0.037
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0397 0.0716 0.2705
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Entamoeba histolytica protein kinase domain containing protein 0.0475 0.0957 0.2563
Schistosoma mansoni ephrin receptor 0.0183 0.0055 0.0095
Giardia lamblia Kinase, CK1 Casein kinase 0.0312 0.0452 0.145
Echinococcus granulosus defective proboscis extension response 0.0272 0.0328 0.0322
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0251 0.0266 0.0334
Toxoplasma gondii CMGC kinase, CK2 family 0.0323 0.0487 0.1043
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0627
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0692 0.1625 0.1972
Trypanosoma cruzi casein kinase II, putative 0.0323 0.0487 0.2109
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0757 0.1827 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0874 0.2188 0.2182
Brugia malayi Protein kinase domain containing protein 0.0586 0.1298 0.1403
Loa Loa (eye worm) TK protein kinase 0.0572 0.1255 0.1356
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0266 0.0459
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0397 0.0716 0.3135
Echinococcus multilocularis cyclin dependent kinase 1 0.0386 0.0681 0.0826
Entamoeba histolytica cell division protein kinase 2, putative 0.0386 0.0681 0.181
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Echinococcus multilocularis casein kinase I alpha 0.0312 0.0452 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0919 0.2327 0.402
Brugia malayi Immunoglobulin I-set domain containing protein 0.0204 0.0119 0.0122
Entamoeba histolytica protein kinase, putative 0.0475 0.0957 0.2563
Plasmodium falciparum calcium-dependent protein kinase 3 0.0278 0.0347 0.1266
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0808 0.1984 0.8811
Echinococcus multilocularis dual specificity 0.0342 0.0545 0.0661
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0295 0.0401 0.0693
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Schistosoma mansoni protein kinase 0.0764 0.1849 0.3193
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0278 0.0347 0.0341
Entamoeba histolytica protein kinase, putative 0.0278 0.0347 0.0902
Echinococcus granulosus cyclin dependent kinase 1 0.0386 0.0681 0.0674
Loa Loa (eye worm) protein kinase domain-containing protein 0.0513 0.1072 0.1158
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1002 0.2582 0.2799
Schistosoma mansoni tyrosine kinase 0.0636 0.1453 0.251
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0376 0.0649 0.1416
Schistosoma mansoni serine/threonine protein kinase 0.131 0.3534 0.6104
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0371 0.0633 0.2763
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0386 0.0681 0.0732
Entamoeba histolytica serine/threonine protein kinase, putative 0.0894 0.225 0.6084
Entamoeba histolytica casein kinase 1, putative 0.0312 0.0452 0.1188
Brugia malayi Protein kinase domain containing protein 0.0838 0.2076 0.2249
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0386 0.0681 0.2536
Brugia malayi P38 map kinase family protein 2 0.0521 0.1098 0.1186
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0269 0.0319 0.055
Schistosoma mansoni hypothetical protein 0.0299 0.0412 0.0712
Entamoeba histolytica protein kinase domain containing protein 0.0397 0.0716 0.1907
Entamoeba histolytica hypothetical protein 0.0397 0.0716 0.1907
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0692 0.1625 0.1972
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0894 0.225 0.2731
Onchocerca volvulus 0.0308 0.0439 0.0633
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0877 0.2198 0.2382
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0287 0.0375 0.0455
Trypanosoma cruzi Protein kinase B 0.0808 0.1984 0.8811
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0119 0.0206
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0371 0.0633 0.1473
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.0317 0.0821
Echinococcus granulosus tyrosine protein kinase shark 0.0799 0.1956 0.1951
Loa Loa (eye worm) TK protein kinase 0.0843 0.2092 0.2266
Echinococcus multilocularis mitogen activated protein kinase 14 0.0521 0.1098 0.1333
Trichomonas vaginalis CAMK family protein kinase 0.0411 0.0759 0.2024
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0218 0.0163 0.0169
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.065 0.1495 0.1814
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0757 0.1827 0.2218
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0466 0.0927 0.1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0419 0.0783 0.4092
Trichomonas vaginalis CMGC family protein kinase 0.0386 0.0681 0.181
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0283 0.0362 0.0626
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0767 0.1856 0.201
Entamoeba histolytica protein kinase, putative 0.0254 0.0273 0.0701
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0371 0.0633 0.1372
Entamoeba histolytica hypothetical protein 0.0875 0.219 0.5921
Plasmodium falciparum NIMA related kinase 1 0.0444 0.086 0.4294
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0371 0.0633 0.2763
Brugia malayi RhoGAP domain containing protein 0.0295 0.0401 0.0428
Echinococcus granulosus roundabout 2 0.0439 0.0846 0.0839
Echinococcus granulosus ephrin type A receptor 4 A 0.0359 0.0599 0.0593
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0271 0.0327 0.0506
Loa Loa (eye worm) hypothetical protein 0.031 0.0447 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.112 0.2946 0.5089
Loa Loa (eye worm) AGC/PKA protein kinase 0.0371 0.0633 0.0681
Echinococcus granulosus dual specificity 0.0342 0.0545 0.0538
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0957 0.2563
Trichomonas vaginalis CMGC family protein kinase 0.0229 0.0195 0.0487
Entamoeba histolytica protein kinase domain containing protein 0.0419 0.0783 0.2089
Echinococcus granulosus mitogen activated protein kinase 3 0.0268 0.0317 0.0311
Schistosoma mansoni nephrin 0.0168 0.0007 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0957 0.2563
Loa Loa (eye worm) hypothetical protein 0.0479 0.0969 0.1045
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0323 0.0487 0.2418
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0342 0.0545 0.1888
Echinococcus multilocularis epidermal growth factor receptor 0.1342 0.3633 0.441
Trypanosoma brucei protein kinase, putative 0.0268 0.0317 0.0479
Echinococcus granulosus growth factor receptor bound protein 2 0.0287 0.0376 0.037
Echinococcus granulosus Protein kinase C brain isozyme 0.0919 0.2327 0.2322
Echinococcus granulosus tyrosine protein kinase ABL1 0.1004 0.2588 0.2583
Onchocerca volvulus Tyrosine kinase homolog 0.1842 0.5177 1
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.04 0.0723 0.0878
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Brugia malayi probable protein kinase 0.0643 0.1474 0.1595
Echinococcus granulosus nervana 2 0.0659 0.1525 0.1519
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0692 0.1625 0.1619
Loa Loa (eye worm) hypothetical protein 0.1403 0.382 0.4144
Echinococcus multilocularis mitogen activated protein kinase 11 0.0521 0.1098 0.1333
Echinococcus multilocularis CDC7 cell division cycle 7 0.0229 0.0195 0.0237
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0276 0.0341 0.0334
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0475 0.0957 0.5078
Leishmania major protein kinase, putative 0.0271 0.0327 0.0853
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0419 0.0783 0.0843
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0957 0.1653
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0513 0.0887
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0371 0.0633 0.2763
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Trichomonas vaginalis AGC family protein kinase 0.0261 0.0294 0.0757
Trypanosoma cruzi aurora B kinase, putative 0.0475 0.0957 0.4213
Echinococcus multilocularis serine:threonine protein kinase 0.037 0.0632 0.0767
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0276 0.0341 0.0414
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0838 0.2076 0.3586
Loa Loa (eye worm) casein kinase 0.0415 0.077 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0266 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0488 0.0997 0.1722
Leishmania major casein kinase II, putative 0.0323 0.0487 0.1615
Echinococcus multilocularis raf serine:threonine protein kinase 0.0277 0.0345 0.0418
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0168 0.0007 0.0012
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Echinococcus granulosus phosphorylase kinase gamma subunit 0.04 0.0723 0.0717
Echinococcus multilocularis dual specificity 0.0342 0.0545 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.0649 0.1121
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0376 0.0649 0.2833
Onchocerca volvulus 0.0308 0.0439 0.0633
Loa Loa (eye worm) hypothetical protein 0.0251 0.0266 0.0282
Brugia malayi Fes/CIP4 homology domain containing protein 0.0294 0.0398 0.0425
Brugia malayi C1-like domain containing protein 0.0645 0.148 0.1601
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0533 0.1136 0.1379
Onchocerca volvulus 0.0312 0.0452 0.0659
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0283 0.0362 0.0386
Entamoeba histolytica protein kinase, putative 0.065 0.1495 0.4028
Echinococcus multilocularis nervana 2 0.0659 0.1525 0.1851
Echinococcus multilocularis aurora kinase A 0.0475 0.0957 0.1162
Echinococcus granulosus calcium activated potassium channel 0.0397 0.0714 0.0708
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0168 0.0007 0.0008
Entamoeba histolytica protein kinase, putative 0.0213 0.0148 0.0358
Echinococcus granulosus protein kinase shaggy 0.0419 0.0783 0.0777
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0295 0.0401 0.0693
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0312 0.0452 0.0484
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0697 0.164 0.1775
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0278 0.0347 0.0422
Echinococcus multilocularis hypothetical protein 0.0299 0.0412 0.05
Schistosoma mansoni protein kinase 0.0276 0.0341 0.0589
Trichomonas vaginalis CAMK family protein kinase 0.037 0.0632 0.1678
Entamoeba histolytica protein kinase, putative 0.0276 0.0341 0.0885
Loa Loa (eye worm) hypothetical protein 0.0215 0.0153 0.0159
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0268 0.0317 0.0338
Schistosoma mansoni serine/threonine protein kinase 0.0919 0.2327 0.402
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0213 0.0148 0.0044
Entamoeba histolytica protein kinase, putative 0.0254 0.0273 0.0701
Leishmania major casein kinase, putative 0.0312 0.0452 0.145
Loa Loa (eye worm) hypothetical protein 0.0265 0.0309 0.0328
Brugia malayi cell division control protein 2 homolog 0.0386 0.0681 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.065 0.1495 0.2582
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0242 0.0238 0.0993
Trypanosoma brucei protein kinase, putative 0.0419 0.0783 0.1795
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Echinococcus granulosus tyrosine kinase 0.0572 0.1255 0.1249
Plasmodium falciparum calcium-dependent protein kinase 2 0.0278 0.0347 0.1266
Echinococcus granulosus myotubularin protein 13 0.0183 0.0055 0.0048
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0599 0.1338 0.3601
Echinococcus granulosus MAP kinase activated protein kinase 2 0.131 0.3534 0.3529
Plasmodium vivax casein kinase 1, putative 0.0312 0.0452 0.2222
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0295 0.0401 0.0487
Brugia malayi Fibronectin type III domain containing protein 0.031 0.0447 0.0479
Onchocerca volvulus 0.1078 0.2818 0.5337
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1002 0.2582 0.487
Plasmodium vivax unspecified product 0.0323 0.0487 0.2418
Loa Loa (eye worm) TK/FAK protein kinase 0.1323 0.3575 0.3878
Echinococcus granulosus STE20 serine:threonine protein kinase 0.116 0.307 0.3065
Schistosoma mansoni serine/threonine protein kinase 0.0948 0.2416 0.4173
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0276 0.0341 0.0414
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0171 0.0016 0.001
Onchocerca volvulus 0.0308 0.0439 0.0633
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0268 0.0317 0.0543
Loa Loa (eye worm) AGC/NDR protein kinase 0.065 0.1495 0.1617
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0757 0.1827 1
Schistosoma mansoni tyrosine kinase 0.1342 0.3633 0.6275
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0475 0.0957 0.0951
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0376 0.0649 0.2833
Schistosoma mansoni atypical protein kinase C 0.1081 0.2825 0.488
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0572 0.1255 0.1523
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0645 0.148 0.1601
Echinococcus granulosus tyrosine protein kinase Fyn 0.0692 0.1625 0.1619
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0627
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0475 0.0957 0.2563
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0769
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0278 0.0347 0.0631
Brugia malayi Protein kinase domain containing protein 0.0626 0.1423 0.1539
Loa Loa (eye worm) hypothetical protein 0.0214 0.0149 0.0155
Entamoeba histolytica protein kinase, putative 0.0213 0.0148 0.0358
Schistosoma mansoni tyrosine kinase 0.0427 0.0809 0.1397
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Trichomonas vaginalis STE family protein kinase 0.0276 0.0341 0.0885
Echinococcus multilocularis Immunoglobulin 0.0272 0.0328 0.0399
Brugia malayi Doublecortin family protein 0.0369 0.0629 0.0676
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Trypanosoma cruzi cdc2-related kinase 1 0.0386 0.0681 0.2975
Plasmodium vivax serine/threonine kinase-1, putative 0.0376 0.0649 0.3334
Schistosoma mansoni serine/threonine protein kinase 0.0932 0.2366 0.4087
Loa Loa (eye worm) CAMK/PHK protein kinase 0.04 0.0723 0.0778
Loa Loa (eye worm) hypothetical protein 0.0333 0.0518 0.0555
Schistosoma mansoni rap gtpase-activating protein 0.0269 0.0319 0.055
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus titin 0.0204 0.0119 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.0681 0.1176
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1534 0.4224 0.5128
Echinococcus granulosus tyrosine protein kinase Fyn 0.0692 0.1625 0.1619
Echinococcus multilocularis casein kinase I alpha 0.0312 0.0452 0.0549
Giardia lamblia Kinase, CMGC GSK 0.0419 0.0783 0.3022
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Schistosoma mansoni protein kinase 0.0203 0.0116 0.0201
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Onchocerca volvulus Serine\/threonine kinase homolog 0.0894 0.225 0.4213
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0196 0.0094 0.0211
Echinococcus multilocularis serine:threonine protein kinase 38 0.065 0.1495 0.1814
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0212 0.0145 0.0138
Loa Loa (eye worm) hypothetical protein 0.0308 0.0439 0.047
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0473 0.095 0.0944
Schistosoma mansoni vav2 0.0346 0.0558 0.0964
Schistosoma mansoni protein kinase C mu 0.0645 0.148 0.2557
Onchocerca volvulus 0.0214 0.015 0.0062
Trichomonas vaginalis CK1 family protein kinase 0.0312 0.0452 0.1188
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0692 0.1625 0.1972
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0692 0.1625 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.1002 0.2582 0.446
Echinococcus multilocularis fibroblast growth factor receptor 4 0.081 0.199 0.2415
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0295 0.0401 0.0428
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0877 0.2198 0.2668
Echinococcus granulosus NDR protein kinase 0.065 0.1495 0.1489
Trypanosoma brucei aurora B kinase 0.0475 0.0957 0.2287
Trichomonas vaginalis CMGC family protein kinase 0.0268 0.0317 0.0821
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0261 0.0294 0.0312
Echinococcus granulosus nervana 2 0.0659 0.1525 0.1519
Loa Loa (eye worm) hypothetical protein 0.0861 0.2148 0.2327
Echinococcus granulosus casein kinase I alpha 0.0312 0.0452 0.0446
Giardia lamblia Kinase, CMGC CDK 0.0386 0.0681 0.2536
Echinococcus multilocularis c src tyrosine kinase 0.0427 0.0809 0.0982
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0312 0.0452 0.0484
Loa Loa (eye worm) hypothetical protein 0.0415 0.077 0.0829
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0251 0.0266 0.1118
Echinococcus multilocularis tyrosine protein kinase shark 0.0799 0.1956 0.2374
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0294 0.0508
Brugia malayi SH2 domain containing protein 0.0308 0.0439 0.047
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0769
Trypanosoma cruzi casein kinase, putative 0.0312 0.0452 0.1953
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0661 0.1531 0.1525
Brugia malayi Protein kinase domain containing protein 0.0376 0.0649 0.0698
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0572 0.1255 0.1249
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0488 0.0997 0.121
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.3148 0.9208 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0692 0.1625 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0016 0.0028
Plasmodium falciparum cGMP-dependent protein kinase 0.0332 0.0513 0.2247
Giardia lamblia Kinase, CAMK CAMKL 0.0251 0.0266 0.0562
Plasmodium falciparum protein kinase, putative 0.0242 0.0238 0.0621
Brugia malayi Protein kinase domain containing protein 0.3148 0.9208 1
Entamoeba histolytica protein kinase domain containing protein 0.0242 0.0238 0.0604
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0692 0.1625 0.1972
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0235 0.0215 0.0227
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0271 0.0327 0.1392
Schistosoma mansoni tyrosine kinase 0.0274 0.0334 0.0577
Giardia lamblia Kinase, CMGC CDK 0.0386 0.0681 0.2536
Leishmania major protein kinase, putative 0.0475 0.0957 0.385
Entamoeba histolytica protein kinase, putative 0.136 0.3688 1
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0269 0.0319 0.0312
Schistosoma mansoni protein kinase 0.0242 0.0238 0.0411
Trichomonas vaginalis CK1 family protein kinase 0.0312 0.0452 0.1188
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0376 0.0649 0.2833
Trichomonas vaginalis CAMK family protein kinase 0.0894 0.225 0.6084
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0333 0.0518 0.0511
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0204 0.0119 0.0122
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0271 0.0327 0.0847
Echinococcus granulosus tyrosine kinase 0.0308 0.0439 0.0433
Loa Loa (eye worm) TK/INSR protein kinase 0.1495 0.4105 0.4454
Loa Loa (eye worm) hypothetical protein 0.031 0.0447 0.0479
Brugia malayi casein kinase I 0.0312 0.0452 0.0484
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0874 0.2188 0.237
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0342 0.0545 0.1212
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0268 0.0317 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.0195 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0094 0.0211
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0268 0.0317 0.1349
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0669 0.1555 0.1549
Loa Loa (eye worm) hypothetical protein 0.0466 0.0927 0.1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0932 0.2366 0.2872
Echinococcus multilocularis serine threonine protein kinase 0.0787 0.1919 0.2329
Brugia malayi Protein kinase domain containing protein 0.0466 0.0927 0.1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0168 0.0007 0.0008
Echinococcus granulosus tyrosine protein kinase Blk 0.0572 0.1255 0.1249
Echinococcus granulosus dual specificity protein kinase clk2 0.0376 0.0649 0.0642
Echinococcus multilocularis tyrosine protein kinase HCK 0.0409 0.0752 0.0913
Echinococcus granulosus tyrosine protein kinase Fyn 0.0692 0.1625 0.1619
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0932 0.2366 0.2564
Plasmodium vivax serine/threonine protein kinase, putative 0.0213 0.0148 0.0498
Onchocerca volvulus 0.0598 0.1335 0.2405
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0251 0.0266 0.1118
Brugia malayi Cam kinase protein 1 0.0278 0.0347 0.037
Brugia malayi protein kinase C II. 0.0786 0.1916 0.2075
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.065 0.1495 0.1489
Schistosoma mansoni tyrosine kinase 0.025 0.0261 0.0451
Brugia malayi Protein kinase domain containing protein 0.1403 0.382 0.4144
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.0633 0.1094
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0575 0.1264 0.1367
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0251 0.0266 0.0282
Entamoeba histolytica protein kinase, putative 0.0397 0.0716 0.1907
Loa Loa (eye worm) hypothetical protein 0.0269 0.0319 0.0339
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0251 0.0266 0.0323
Echinococcus granulosus serine/threonine protein kinase 0.0808 0.1984 0.1979
Echinococcus multilocularis dual specificity protein kinase clk2 0.0376 0.0649 0.0788
Schistosoma mansoni protein kinase 0.0643 0.1474 0.2547
Brugia malayi Variant SH3 domain containing protein 0.0283 0.0362 0.0386
Trichomonas vaginalis AGC family protein kinase 0.136 0.3688 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0271 0.0327 0.1392
Plasmodium vivax protein kinase Crk2 0.0386 0.0681 0.3514
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0251 0.0266 0.0562
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0278 0.0347 0.1628
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0369 0.0629 0.0676
Brugia malayi serine/threonine-protein kinase 6 0.0475 0.0957 0.1033
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0669 0.1555 0.1549
Brugia malayi Protein kinase domain containing protein 0.0229 0.0195 0.0204
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0575 0.1264 0.1367
Brugia malayi Protein kinase domain containing protein 0.065 0.1495 0.1617
Onchocerca volvulus 0.0229 0.0195 0.015
Entamoeba histolytica cell division protein kinase 2, putative 0.0386 0.0681 0.181
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.0439 0.047
Loa Loa (eye worm) hypothetical protein 0.031 0.0447 0.0479
Trypanosoma brucei polo-like protein kinase 0.0894 0.225 0.5939
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0386 0.0681 0.0732
Schistosoma mansoni tyrosine kinase 0.0841 0.2085 0.3601
Trichomonas vaginalis AGC family protein kinase 0.0371 0.0633 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.081 0.199 0.1984
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0513 0.0887
Plasmodium falciparum serine/threonine protein kinase 0.0213 0.0148 0.0088
Brugia malayi protein kinase C3,putative 0.0508 0.1059 0.1143
Brugia malayi Serine/threonine-protein kinase SULU 0.0533 0.1136 0.1227
Trichomonas vaginalis CMGC family protein kinase 0.0342 0.0545 0.144
Brugia malayi casein kinase 1, delta 0.0312 0.0452 0.0484
Trichomonas vaginalis CAMK family protein kinase 0.0251 0.0266 0.068
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0287 0.0375 0.0368
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0371 0.0633 0.0681
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0278 0.0347 0.0564
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0419 0.0783 0.1913
Echinococcus granulosus epidermal growth factor receptor 0.2041 0.5789 0.5787
Loa Loa (eye worm) hypothetical protein 0.0299 0.0412 0.0441
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0692 0.1625 0.1972
Echinococcus granulosus protein kinase c epsilon type 0.0786 0.1916 0.1911
Echinococcus multilocularis rac serine:threonine kinase 0.0808 0.1984 0.2408
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0488 0.0997 0.1076
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0764 0.1849 0.2244
Brugia malayi serine/threonine protein kinase 6 0.0475 0.0957 0.1033
Trypanosoma brucei Casein kinase II 0.0323 0.0487 0.0959
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0669 0.1555 0.1887
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0444 0.086 0.453
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1182 0.3138 0.3809
Schistosoma mansoni serine/threonine protein kinase 0.0874 0.2188 0.3779
Loa Loa (eye worm) hypothetical protein 0.0272 0.0328 0.0349
Echinococcus granulosus casein kinase I delta 0.0312 0.0452 0.0446
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0332 0.0513 0.0623
Plasmodium falciparum serine/threonine protein kinase KIN 0.0251 0.0266 0.0785
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0488 0.0997 0.0991
Trypanosoma brucei casein kinase I, isoform 2 0.0312 0.0452 0.0861
Trypanosoma cruzi polo-like protein kinase, putative 0.0894 0.225 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0572 0.1255 0.1523
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0269 0.0319 0.0483
Schistosoma mansoni tyrosine kinase 0.2041 0.5789 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0689 0.1616 0.1749
Brugia malayi Immunoglobulin I-set domain containing protein 0.0878 0.2199 0.2382
Trichomonas vaginalis STE family protein kinase 0.0276 0.0341 0.0885
Schistosoma mansoni protein kinase 0.0323 0.0487 0.0841
Schistosoma mansoni serine/threonine protein kinase 0.04 0.0723 0.1249
Echinococcus multilocularis casein kinase I gamma 0.0513 0.1072 0.1301
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.037 0.0632 0.068
Entamoeba histolytica protein kinase, putative 0.136 0.3688 1
Brugia malayi STE20-like kinase MST 0.0849 0.2111 0.2286
Trichomonas vaginalis CMGC family protein kinase 0.0323 0.0487 0.1283
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0371 0.0633 0.0769
Entamoeba histolytica protein kinase domain containing protein 0.0419 0.0783 0.2089
Brugia malayi Variant SH3 domain containing protein 0.0283 0.0362 0.0386
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0575 0.1264 0.1535
Brugia malayi Furin-like cysteine rich region family protein 0.2041 0.5789 0.6285
Giardia lamblia Aurora kinase 0.0475 0.0957 0.385
Trypanosoma cruzi casein kinase, putative 0.0312 0.0452 0.1953
Echinococcus multilocularis mitogen activated protein kinase 11 0.0521 0.1098 0.1333
Echinococcus multilocularis expressed conserved protein 0.0332 0.0513 0.0623
Brugia malayi Protein kinase domain containing protein 0.1054 0.2744 0.2975
Brugia malayi Temporarily assigned gene name protein 59 0.0433 0.0826 0.089
Echinococcus granulosus cGMP dependent protein kinase 1 0.0332 0.0513 0.0507
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0273 0.0331 0.0325
Loa Loa (eye worm) hypothetical protein 0.0183 0.0055 0.0052
Echinococcus multilocularis PAK box P21 Rho binding 0.0203 0.0116 0.0141
Entamoeba histolytica p21-activated kinase 0.0327 0.0498 0.1312
Giardia lamblia Kinase, AGC AKT 0.038 0.0663 0.245
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.065 0.1495 0.1489
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0473 0.095 0.1153
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0669 0.1555 0.1887
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.116 0.307 0.3726
Brugia malayi Protein kinase domain containing protein 0.0308 0.0439 0.047
Entamoeba histolytica protein kinase, putative 0.0261 0.0294 0.0757
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0225 0.0184 0.0177
Brugia malayi p70 ribosomal S6 kinase beta 0.1309 0.3531 0.383
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.0714 0.1234
Loa Loa (eye worm) hypothetical protein 0.0466 0.0927 0.1
Schistosoma mansoni hypothetical protein 0.0299 0.0412 0.0712
Echinococcus granulosus c src tyrosine kinase 0.0427 0.0809 0.0802
Echinococcus granulosus Glutaredoxin protein 5 0.0659 0.1525 0.1519
Loa Loa (eye worm) hypothetical protein 0.03 0.0414 0.0443

Activities

Activity type Activity value Assay description Source Reference
beta t1/2 (ADMET) = 1.5 hr Terminal half life in rat at 3 mg/kg, iv ChEMBL. 16942012
CL (ADMET) = 39 ml/min.kg Clearance in rat at 3 mg/kg, iv ChEMBL. 16942012
EC50 (functional) = 11 nM Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter gene ChEMBL. 16942012
EC50 (functional) = 11 nM Activity at ERalpha L384M/M421G/G521R mutant in HeLa cells assessed as activation of SEAP reporter gene ChEMBL. 16942012
IC50 (binding) = 29 nM Binding affinity to ERalpha L384M/M421G mutant ChEMBL. 16942012
IC50 (binding) = 29 nM Binding affinity to ERalpha L384M/M421G mutant ChEMBL. 16942012
IC50 (binding) = 100 nM Binding affinity to human ER beta ChEMBL. 16942012
IC50 (binding) = 100 nM Binding affinity to human ER beta ChEMBL. 16942012
IC50 (binding) = 220 nM Binding affinity to human ER alpha ChEMBL. 16942012
IC50 (binding) = 220 nM Binding affinity to human ER alpha ChEMBL. 16942012

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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