Detailed information for compound 38861

Basic information

Technical information
  • TDR Targets ID: 38861
  • Name: 4-amino-N-[(8R)-1-azabicyclo[2.2.2]octan-8-yl ]-5-chloro-2-methoxybenzamide
  • MW: 309.791 | Formula: C15H20ClN3O2
  • H donors: 2 H acceptors: 1 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(N)c(cc1C(=O)N[C@H]1CN2CCC1CC2)Cl
  • InChi: 1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
  • InChiKey: FEROPKNOYKURCJ-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-5-chloro-2-methoxy-N-[(3R)-quinuclidin-3-yl]benzamide
  • 4-amino-5-chloro-2-methoxy-N-[(3R)-3-quinuclidinyl]benzamide
  • N-[(8R)-1-azabicyclo[2.2.2]octan-8-yl]-4-azanyl-5-chloro-2-methoxy-benzamide
  • zacopride
  • 4-amino-N-[(8R)-1-azabicyclo[2.2.2]octan-8-yl]-5-chloro-2-methoxy-benzamide
  • PDSP2_001683
  • PDSP1_001700

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus 5-hydroxytryptamine (serotonin) receptor 3A References
Rattus norvegicus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor beta Starlite/ChEMBL References
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Mus musculus 5-hydroxytryptamine (serotonin) receptor 3B Starlite/ChEMBL References
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 2 (5-HT2) receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References
Rattus norvegicus Serotonin 1 (5-HT1) receptor Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Starlite/ChEMBL No references
Cavia porcellus Serotonin 4 (5-HT4) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Get druggable targets OG5_133042 All targets in OG5_133042
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 410 aa 24.1 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 5-hydroxytryptamine (serotonin) receptor 3B 437 aa 414 aa 23.7 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   406 aa 407 aa 25.1 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 346 aa 23.1 %
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Serotonin 1 (5-HT1) receptor   366 aa 325 aa 32.9 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 336 aa 24.1 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Loa Loa (eye worm) neuropeptide F receptor Serotonin 1 (5-HT1) receptor   366 aa 337 aa 22.8 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Echinococcus multilocularis serotonin receptor Serotonin 1 (5-HT1) receptor   366 aa 413 aa 24.5 %
Brugia malayi sulfakinin receptor protein Serotonin 1 (5-HT1) receptor   366 aa 342 aa 19.9 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Echinococcus multilocularis neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.0 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 4 (5-HT4) receptor   406 aa 389 aa 19.3 %
Echinococcus granulosus orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Serotonin 1 (5-HT1) receptor   366 aa 324 aa 21.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Serotonin 1 (5-HT1) receptor   366 aa 355 aa 30.1 %
Brugia malayi GnHR receptor homolog Serotonin 4 (5-HT4) receptor   388 aa 358 aa 20.7 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 358 aa 22.3 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 360 aa 21.4 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 325 aa 22.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 4 (5-HT4) receptor   406 aa 445 aa 22.2 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 4 (5-HT4) receptor   388 aa 374 aa 18.7 %
Brugia malayi follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 319 aa 24.5 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Serotonin 4 (5-HT4) receptor   406 aa 390 aa 27.9 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 352 aa 21.3 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1 (5-HT1) receptor   366 aa 371 aa 20.2 %
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 365 aa 36.7 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   406 aa 387 aa 30.5 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1 (5-HT1) receptor   366 aa 398 aa 21.9 %
Echinococcus multilocularis rhodopsin orphan GPCR Serotonin 1 (5-HT1) receptor   366 aa 335 aa 20.3 %
Onchocerca volvulus Serotonin 4 (5-HT4) receptor   388 aa 315 aa 19.7 %
Echinococcus granulosus allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 345 aa 25.2 %
Echinococcus multilocularis allatostatin A receptor Serotonin 4 (5-HT4) receptor   406 aa 331 aa 26.0 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 356 aa 30.9 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Brugia malayi Cation transporter family protein 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 484 aa 469 aa 28.6 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Loa Loa (eye worm) hypothetical protein Serotonin 1 (5-HT1) receptor   366 aa 331 aa 22.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 398 aa 29.1 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 4 (5-HT4) receptor   388 aa 352 aa 28.4 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 4 (5-HT4) receptor   406 aa 348 aa 30.7 %
Schistosoma mansoni peptide (allatostatin)-like receptor Serotonin 4 (5-HT4) receptor   388 aa 332 aa 23.5 %
Brugia malayi Cation transporter family protein 5-hydroxytryptamine (serotonin) receptor 3A 483 aa 501 aa 28.7 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 4 (5-HT4) receptor   406 aa 351 aa 22.2 %
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Serotonin 1 (5-HT1) receptor   366 aa 331 aa 26.0 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Onchocerca volvulus Serotonin 1 (5-HT1) receptor   366 aa 344 aa 18.3 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Loa Loa (eye worm) hypothetical protein Serotonin 1 (5-HT1) receptor   366 aa 350 aa 35.7 %
Schistosoma japonicum Rhodopsin, putative Serotonin 1 (5-HT1) receptor   366 aa 364 aa 20.1 %
Loa Loa (eye worm) follicle stimulating hormone receptor Serotonin 4 (5-HT4) receptor   388 aa 345 aa 23.5 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Echinococcus multilocularis somatostatin receptor Serotonin 1 (5-HT1) receptor   366 aa 299 aa 19.1 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Echinococcus granulosus neuropeptide receptor Serotonin 4 (5-HT4) receptor   388 aa 325 aa 24.3 %
Schistosoma mansoni adenoreceptor Serotonin 1 (5-HT1) receptor   366 aa 341 aa 29.9 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Echinococcus granulosus rhodopsin orphan GPCR Serotonin 1 (5-HT1) receptor   366 aa 335 aa 20.6 %
Echinococcus granulosus dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1 (5-HT1) receptor   366 aa 333 aa 20.1 %
Echinococcus granulosus somatostatin receptor Serotonin 4 (5-HT4) receptor   388 aa 375 aa 21.6 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 4 (5-HT4) receptor   388 aa 360 aa 21.7 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1 (5-HT1) receptor   366 aa 405 aa 26.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ecdysone induced protein 78C 0.0192 0.1062 0.1937
Brugia malayi G-protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0779 0.142
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0213 0.0388
Echinococcus granulosus sex peptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni brg-1 associated factor 0.0877 0.5482 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0041 0.009 0.0165
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.013 0.0237
Onchocerca volvulus 0.0233 0.133 0.2395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0192 0.1062 0.1937
Brugia malayi tailless protein 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0596 0.0491
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.009 0.0409 0.0719
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0213 0.0388
Trypanosoma brucei histone deacetylase 1 0.0195 0.1086 0.5596
Echinococcus granulosus neuropeptide s receptor 0.006 0.0213 0.0388
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0096 0.0134
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Entamoeba histolytica histone deacetylase, putative 0.0195 0.1086 1
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Schistosoma mansoni tyrosine kinase 0.0041 0.009 0.0136
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.009 0.0409 0.0708
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.0101 0.0479 0.0874
Schistosoma mansoni adenoreceptor 0.006 0.0213 0.036
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.009 0.0409 0.0746
Onchocerca volvulus Putative nachr subunit 0.0148 0.0779 0.1385
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Brugia malayi RE15519p 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Echinococcus multilocularis serotonin receptor 0.006 0.0213 0.0388
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.1376
Loa Loa (eye worm) TK/EGFR protein kinase 0.0128 0.0652 0.119
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0148 0.0779 0.142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0192 0.1062 0.1937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0192 0.1062 0.1937
Mycobacterium ulcerans thymidylate synthase 0.0108 0.0521 0.0416
Echinococcus multilocularis fmrfamide receptor 0.006 0.0213 0.0388
Leishmania major histone deacetylase, putative 0.0195 0.1086 0.5596
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus multilocularis Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0596 0.0491
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Mycobacterium leprae Isocitrate lyase 0.0739 0.4595 0.4535
Brugia malayi larval opioid receptor 0.006 0.0213 0.0388
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0192 0.1062 0.1937
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0213 0.0388
Echinococcus multilocularis thyroid hormone receptor alpha 0.0192 0.1062 0.1937
Echinococcus multilocularis chromobox protein 1 0.0069 0.0273 0.0499
Echinococcus granulosus g-protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) histone deacetylase 11 0.0078 0.0329 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0192 0.1062 0.1937
Echinococcus multilocularis FTZ F1 alpha 0.0192 0.1062 0.1937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0148 0.0779 0.142
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0213 0.0388
Schistosoma mansoni chromobox protein 0.0069 0.0273 0.0471
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0085 0.0375 0.0658
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0213 0.0388
Loa Loa (eye worm) thymidylate synthase 0.0108 0.0521 0.0951
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Brugia malayi nuclear receptor NHR-67 0.009 0.0409 0.0746
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0213 0.036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus granulosus zinc finger protein Ran binding 0.0312 0.1838 0.3353
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Loa Loa (eye worm) hypothetical protein 0.0073 0.0294 0.0537
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi conserved hypotetical protein 0.009 0.0409 0.0746
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Echinococcus granulosus nAChR subunit 0.0148 0.0779 0.142
Plasmodium vivax histone deacetylase 2, putative 0.0151 0.0797 0.1362
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0312 0.1838 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Plasmodium falciparum histone deacetylase 1 0.0195 0.1086 0.1786
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0157 0.028
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Loa Loa (eye worm) histone deacetylase 1 0.0195 0.1086 0.198
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Schistosoma mansoni hypothetical protein 0.0312 0.1838 0.3333
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0213 0.0388
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036
Toxoplasma gondii ran binding protein 0.0312 0.1838 0.3281
Brugia malayi Serotonin receptor 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor E75 0.009 0.0409 0.0746
Echinococcus multilocularis histone deacetylase 1 0.0195 0.1086 0.198
Loa Loa (eye worm) hypothetical protein 0.0316 0.1863 0.3398
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0312 0.1838 0.3353
Brugia malayi Heterochromatin protein 1 0.0069 0.0273 0.0499
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0148 0.0779 0.142
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi neuropeptide F receptor 0.006 0.0213 0.0388
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0041 0.009 0.0165
Schistosoma mansoni retinoic acid receptor RXR 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0077 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Trypanosoma brucei hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0213 0.0388
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0101 0.0479 0.0874
Schistosoma mansoni histone deacetylase 4 5 0.0151 0.0797 0.143
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0148 0.0779 0.142
Schistosoma mansoni nuclear hormone receptor 0.009 0.0409 0.0719
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0213 0.0388
Plasmodium vivax histone deacetylase, putative 0.0078 0.0329 0.0499
Onchocerca volvulus 0.006 0.0213 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0078 0.0329 0.0601
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Schistosoma mansoni RNA binding protein 0.0312 0.1838 0.3333
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0192 0.1062 0.1914
Brugia malayi Cation transporter family protein 0.0148 0.0779 0.142
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0213 0.0388
Onchocerca volvulus 0.0312 0.1838 0.3325
Brugia malayi histone deacetylase 11 0.0078 0.0329 0.0601
Brugia malayi G-protein coupled receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.0085 0.0375 0.0646
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.005 0.0091
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0779 0.142
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0779 0.142
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Schistosoma mansoni myosin xvIII 0.006 0.0213 0.036
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Onchocerca volvulus Protein ultraspiracle homolog 0.0192 0.1062 0.1904
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0213 0.0388
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0213 0.036
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0213 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.013 0.0131
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Brugia malayi thymidylate synthase 0.0108 0.0521 0.0951
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.013 0.0131
Onchocerca volvulus 0.0148 0.0779 0.1385
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Onchocerca volvulus 0.0108 0.0521 0.0914
Loa Loa (eye worm) ACC-1 protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Schistosoma mansoni thyroid hormone receptor 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.0409 0.0746
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0213 0.036
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0213 0.0388
Brugia malayi histone deacetylase 1 (HD1) 0.0195 0.1086 0.198
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus granulosus FTZ F1 alpha 0.0192 0.1062 0.1937
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.1262
Trypanosoma brucei histone deacetylase 2 0.0078 0.0329 0.1168
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Echinococcus multilocularis neuropeptide s receptor 0.006 0.0213 0.0388
Brugia malayi brahma associated protein 60 kDa 0.0877 0.5482 1
Echinococcus granulosus histone deacetylase 8 0.0078 0.0329 0.0601
Brugia malayi Dopamine receptor protein 2 0.006 0.0213 0.0388
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0779 0.142
Schistosoma mansoni RAR-like nuclear receptor 0.0192 0.1062 0.1914
Echinococcus granulosus orexin receptor type 2 0.006 0.0213 0.0388
Brugia malayi glutathione reductase 0.0047 0.013 0.0237
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Loa Loa (eye worm) histone deacetylase 7A 0.0151 0.0797 0.1455
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0779 0.142
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0518 0.0413
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit 0.0062 0.0229 0.039
Onchocerca volvulus 0.0085 0.0375 0.0646
Loa Loa (eye worm) nuclear hormone receptor 0.009 0.0409 0.0746
Echinococcus multilocularis neuropeptide receptor 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0192 0.1062 0.1937
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0596 0.0491
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0518 0.0413
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Plasmodium vivax hypothetical protein, conserved 0.0877 0.5482 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0213 0.0388
Brugia malayi Protein kinase domain containing protein 0.0041 0.009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Trypanosoma cruzi histone deacetylase, putative 0.0078 0.0329 0.1168
Schistosoma mansoni chromobox protein 0.0069 0.0273 0.0471
Schistosoma mansoni nuclear receptor 0.009 0.0409 0.0719
Schistosoma mansoni tyrosine kinase 0.0128 0.0652 0.1165
Echinococcus multilocularis chromobox protein 1 0.0069 0.0273 0.0499
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi AKH receptor 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0233 0.133 0.2404
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.027 0.0493
Echinococcus granulosus epidermal growth factor receptor 0.0128 0.0652 0.119
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Onchocerca volvulus 0.0877 0.5482 1
Onchocerca volvulus 0.0047 0.0132 0.02
Onchocerca volvulus 0.0312 0.1838 0.3325
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0213 0.036
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0213 0.0388
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0229 0.039
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0062 0.0229 0.0418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0192 0.1062 0.1914
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0059 0.0107
Onchocerca volvulus 0.0312 0.1838 0.3325
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0152 0.0805 0.1376
Mycobacterium ulcerans isocitrate lyase Icl 0.1577 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0406 0.2446 0.4462
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0148 0.0779 0.142
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Echinococcus multilocularis ring and YY1 binding protein 0.0312 0.1838 0.3353
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0148 0.0779 0.142
Onchocerca volvulus 0.0233 0.133 0.2395
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0213 0.0388
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Trypanosoma brucei histone deacetylase, putative 0.0151 0.0797 0.3909
Mycobacterium tuberculosis Probable reductase 0.0107 0.0518 0.0413
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0213 0.0388
Echinococcus granulosus chromobox protein 1 0.0069 0.0273 0.0499
Onchocerca volvulus 0.006 0.0213 0.0348
Onchocerca volvulus 0.0062 0.0229 0.0379
Brugia malayi Dihydrofolate reductase 0.0044 0.011 0.02
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.027 0.0493
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0233 0.133 0.2426
Schistosoma mansoni histamine h1 receptor 0.006 0.0213 0.036
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0213 0.036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0059 0.0107
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0312 0.1838 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0213 0.0388
Brugia malayi ecdysteroid receptor 0.0192 0.1062 0.1937
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0062 0.0229 0.0418
Echinococcus multilocularis nAChR subunit 0.0085 0.0375 0.0685
Brugia malayi Melatonin receptor type 1A 0.006 0.0213 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0192 0.1062 0.1937
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.011 0.02
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0312 0.1838 0.3353
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0192 0.1062 0.1937
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Echinococcus granulosus neuropeptide receptor 0.006 0.0213 0.0388
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0213 0.0388
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0213 0.036
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0148 0.0779 0.142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi ecdysone receptor 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0233 0.133 0.2426
Brugia malayi Histone deacetylase family protein 0.0151 0.0797 0.1455
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0213 0.0388
Echinococcus multilocularis somatostatin receptor 0.006 0.0213 0.0388
Brugia malayi Cation transporter family protein 0.0148 0.0779 0.142
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0877 0.5482 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0518 0.0413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis allatostatin A receptor 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0192 0.1062 0.1937
Loa Loa (eye worm) steroid hormone receptor 0.0192 0.1062 0.1937
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0312 0.1838 0.3325
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0148 0.0779 0.142
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0062 0.0229 0.0418
Schistosoma mansoni tyrosine kinase 0.0041 0.009 0.0136
Echinococcus multilocularis nuclear receptor nhr 48 0.009 0.0409 0.0746
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.0409 0.0746
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Schistosoma mansoni histone deacetylase 1 2 3 0.0078 0.0329 0.0573
Onchocerca volvulus 0.0062 0.0229 0.0379
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0409 0.0708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0192 0.1062 0.1937
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0213 0.0388
Echinococcus granulosus g protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi nuclear hormone receptor family member odr-7 0.009 0.0409 0.0746
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0213 0.0388
Brugia malayi nuclear receptor RXR 0.009 0.0409 0.0746
Onchocerca volvulus 0.006 0.0213 0.0348
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus allatostatin A receptor 0.006 0.0213 0.0388
Schistosoma mansoni hypothetical protein 0.0051 0.0158 0.026
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Cation transporter family protein 0.0233 0.133 0.2426
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Trypanosoma brucei histone deacetylase 4 0.0151 0.0797 0.3909
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0779 0.142
Plasmodium falciparum histone deacetylase 2 0.0151 0.0797 0.1248
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0596 0.0491
Echinococcus multilocularis ecdysone induced protein 78C 0.0192 0.1062 0.1937
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0192 0.1062 0.1937
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0273 0.0492
Loa Loa (eye worm) hypothetical protein 0.0039 0.0077 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0877 0.5482 1
Schistosoma mansoni tyrosine kinase 0.0069 0.027 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Trypanosoma brucei hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus multilocularis nAChR subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus chromobox protein 1 0.0069 0.0273 0.0499
Brugia malayi Histone deacetylase family protein 0.0151 0.0797 0.1455
Loa Loa (eye worm) acetylcholine receptor protein 0.0062 0.0229 0.0418
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0273 0.0492
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0213 0.0388
Schistosoma mansoni zinc finger protein 0.009 0.0409 0.0719
Schistosoma mansoni opsin-like receptor 0.006 0.0213 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Brugia malayi photoreceptor-specific nuclear receptor 0.0192 0.1062 0.1937
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0096 0.0168
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0192 0.1062 0.1937
Onchocerca volvulus 0.0062 0.0229 0.0379
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1671 0.3044
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0108 0.0521 0.0416
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis 0.004 0.0082 0.0149
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0041
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Echinococcus granulosus nAChR subunit 0.0085 0.0375 0.0685
Echinococcus granulosus fmrfamide receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Brugia malayi Dopamine receptor 0.006 0.0213 0.0388
Brugia malayi excitatory GABA receptor EXP-1A 0.0148 0.0779 0.142
Schistosoma mansoni histone deacetylase 0.0195 0.1086 0.1957
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.0157 0.016
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Onchocerca volvulus 0.006 0.0213 0.0348
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0229 0.039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0518 0.0413
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0192 0.1062 0.1937
Brugia malayi sulfakinin receptor protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0213 0.0388
Trypanosoma brucei histone deacetylase 3 0.0151 0.0797 0.3909
Loa Loa (eye worm) hypothetical protein 0.0171 0.0927 0.1691
Echinococcus multilocularis neuropeptide receptor 0.006 0.0213 0.0388
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0213 0.0388
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Schistosoma mansoni coup transcription factor 0.0192 0.1062 0.1914
Schistosoma mansoni acetylcholine receptor subunit beta 0.0062 0.0229 0.039
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0213 0.0388
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0192 0.1062 0.1937
Plasmodium falciparum histone deacetylase, putative 0.0151 0.0797 0.1248
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0213 0.0388
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0192 0.1062 0.1937
Trypanosoma cruzi histone deacetylase 1, putative 0.0195 0.1086 0.5596
Echinococcus granulosus nuclear receptor nhr 48 0.009 0.0409 0.0746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0192 0.1062 0.1937
Brugia malayi steroid hormone receptor 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Brugia malayi hypothetical protein 0.009 0.0409 0.0746
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0134
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0101 0.0479 0.0874
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0062 0.0229 0.0418
Onchocerca volvulus 0.0148 0.0779 0.1385
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0192 0.1062 0.1904
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0192 0.1062 0.1937
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0312 0.1838 1
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Onchocerca volvulus 0.006 0.0213 0.0348
Schistosoma mansoni nuclear hormone receptor 0.0192 0.1062 0.1914
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0213 0.0388
Echinococcus multilocularis histone deacetylase 8 0.0078 0.0329 0.0601
Echinococcus granulosus SWI:SNF matrix associated 0.0877 0.5482 1
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0192 0.1062 0.1937
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.013 0.002
Schistosoma mansoni acetylcholine receptor-related 0.0062 0.0229 0.039
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis g protein coupled receptor 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.011 0.02
Schistosoma mansoni amine GPCR 0.006 0.0213 0.036
Brugia malayi G protein-coupled receptor 0.006 0.0213 0.0388
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0213 0.036
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0062 0.0229 0.0418
Schistosoma mansoni tyrosine kinase 0.0069 0.027 0.0465
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.1577 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0312 0.1838 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) GABA receptor subunit 0.0085 0.0375 0.0685
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus thyroid hormone receptor alpha 0.009 0.0409 0.0746
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Brugia malayi nuclear receptor NHR-88 0.009 0.0409 0.0746
Leishmania major histone deacetylase, putative 0.0151 0.0797 0.3909
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0148 0.0779 0.142
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0213 0.0388
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0213 0.0388
Toxoplasma gondii histone deacetylase HDAC3 0.0195 0.1086 0.1894
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0192 0.1062 0.1937
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0312 0.1838 0.3353
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0148 0.0779 0.142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 1 0.0195 0.1086 0.198
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.013 0.0237
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0213 0.036
Plasmodium vivax histone deacetylase, putative 0.0151 0.0797 0.1362
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Brugia malayi nuclear receptor NHR-88 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Onchocerca volvulus 0.0192 0.1062 0.1904
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0192 0.1062 0.1937
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0213 0.0348
Schistosoma mansoni neurotransmitter gated ion channel 0.0085 0.0375 0.0658
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Brugia malayi Steroid receptor seven-up type 2 0.0192 0.1062 0.1937
Trypanosoma cruzi WLM domain containing protein, putative 0.0312 0.1838 1
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Loa Loa (eye worm) LGC-31 protein 0.0148 0.0779 0.142
Onchocerca volvulus 0.0148 0.0779 0.1385
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0213 0.036
Leishmania major histone deacetylase, putative 0.0195 0.1086 0.5596
Schistosoma mansoni nAChR subunit 0.0148 0.0779 0.1395
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0195 0.1086 0.198
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0312 0.1838 0.3192
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0213 0.0388
Chlamydia trachomatis DNA topoisomerase I 0.0877 0.5482 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0312 0.1838 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0059 0.0107
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0148 0.0779 0.142
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0312 0.1838 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0312 0.1838 0.3281
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0518 0.0413
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Echinococcus granulosus thymidylate synthase 0.0108 0.0521 0.0951
Brugia malayi Pre-SET motif family protein 0.0251 0.1447 0.264
Loa Loa (eye worm) hypothetical protein 0.0073 0.0294 0.0537
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Brugia malayi Furin-like cysteine rich region family protein 0.0128 0.0652 0.119
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Schistosoma mansoni dihydrofolate reductase 0.0044 0.011 0.0171
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0059 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0192 0.1062 0.1914
Echinococcus multilocularis histone deacetylase 6 0.0151 0.0797 0.1455
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis serotonin receptor 0.006 0.0213 0.0388
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Brugia malayi GnHR receptor homolog 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.027 0.0493
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0213 0.0388
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0213 0.0388
Loa Loa (eye worm) brahma associated protein 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi nuclear hormone receptor 0.009 0.0409 0.0746
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi YY1-associated factor 2 0.0312 0.1838 0.3353
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0213 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Onchocerca volvulus Bile acid receptor homolog 0.0192 0.1062 0.1904
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0059 0.0078
Schistosoma mansoni fusion 0.0312 0.1838 0.3333
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0148 0.0779 0.142
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0213 0.0388
Schistosoma mansoni histone deacetylase 4 5 0.0151 0.0797 0.143
Schistosoma mansoni nAChR subunit 0.0062 0.0229 0.039
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi brahma associated protein 60 kDa 0.0877 0.5482 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0213 0.0388
Echinococcus granulosus somatostatin receptor 0.006 0.0213 0.0388
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.0157 0.0048
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0085 0.0375 0.0685
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0101 0.0479 0.0847
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0108 0.0521 0.0925
Schistosoma mansoni histone deacetylase 0.0195 0.1086 0.1957
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Chlamydia trachomatis SWIB complex protein 0.0877 0.5482 1
Onchocerca volvulus 0.0312 0.1838 0.3325
Toxoplasma gondii histone deacetylase HDAC4 0.0078 0.0329 0.0499
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0192 0.1062 0.1937
Echinococcus multilocularis fmrfamide receptor 0.006 0.0213 0.0388
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0213 0.036
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.009 0.0409 0.0746
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0148 0.0779 0.142
Brugia malayi Histone deacetylase 1 0.0195 0.1086 0.198
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Toxoplasma gondii histone deacetylase HDAC2 0.0195 0.1086 0.1894
Echinococcus multilocularis epidermal growth factor receptor 0.0128 0.0652 0.119
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0085 0.0375 0.0685
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0085 0.0375 0.0658
Brugia malayi Serotonin receptor 0.0331 0.1959 0.3574
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036
Schistosoma mansoni nuclear receptor 0.009 0.0409 0.0719
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0213 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0134
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Toxoplasma gondii histone deacetylase HDAC5 0.0078 0.0329 0.0499
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.1577 1 1
Brugia malayi follicle stimulating hormone receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) histone deacetylase 3 0.0195 0.1086 0.198
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0096 0.0168
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.0213 0.0388
Toxoplasma gondii thioredoxin reductase 0.0047 0.013 0.0131
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni hypothetical protein 0.006 0.0213 0.036
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0213 0.0388
Brugia malayi orphan nuclear receptor NR2E1 0.009 0.0409 0.0746
Onchocerca volvulus 0.006 0.0213 0.0348
Echinococcus multilocularis zinc finger protein Ran binding 0.0312 0.1838 0.3353
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0148 0.0779 0.1395
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.009 0.0409 0.0719
Echinococcus granulosus hypothetical protein 0.0466 0.2833 0.5168
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0213 0.036
Echinococcus granulosus histone deacetylase 0.0151 0.0797 0.1455
Brugia malayi histone deacetylase 3 (HD3) 0.0195 0.1086 0.198
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0233 0.133 0.2404
Giardia lamblia Histone deacetylase 0.0195 0.1086 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1447 0.264
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Onchocerca volvulus 0.009 0.0409 0.0708
Echinococcus granulosus glycine receptor subunit beta 0.0148 0.0779 0.142
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0148 0.0779 0.142
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0108 0.0521 0.0416
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Schistosoma mansoni biogenic amine receptor 0.006 0.0213 0.036
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0101 0.0479 0.0874
Echinococcus multilocularis insulin receptor 0.0041 0.009 0.0165
Schistosoma mansoni nuclear receptor nhr-48 0.009 0.0409 0.0719
Echinococcus multilocularis sex peptide receptor 0.006 0.0213 0.0388
Schistosoma mansoni nuclear hormone receptor 0.009 0.0409 0.0719
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Echinococcus granulosus insulin receptor 0.0041 0.009 0.0165
Echinococcus granulosus histone deacetylase 7 0.0151 0.0797 0.1455
Brugia malayi hypothetical protein 0.0062 0.0229 0.0418
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0213 0.0348
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0213 0.0388
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0152 0.0805 0.3953
Onchocerca volvulus 0.006 0.0213 0.0348
Onchocerca volvulus 0.006 0.0213 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0062 0.0229 0.0418
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0213 0.0388
Brugia malayi hypothetical protein 0.0101 0.0479 0.0874
Echinococcus multilocularis thymidylate synthase 0.0108 0.0521 0.0951
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Echinococcus multilocularis orexin receptor type 2 0.006 0.0213 0.0388
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Onchocerca volvulus 0.006 0.0213 0.0348
Trypanosoma cruzi histone deacetylase 1, putative 0.0195 0.1086 0.5596
Echinococcus granulosus Zinc finger RanBP2 type 0.0312 0.1838 0.3353
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0213 0.036
Schistosoma mansoni histone deacetylase hda2 0.0078 0.0329 0.0573
Brugia malayi SWIB/MDM2 domain containing protein 0.0877 0.5482 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0062 0.0229 0.0418
Brugia malayi Cytochrome P450 family protein 0.0066 0.0255 0.0465
Echinococcus multilocularis glycine receptor subunit beta 0.0148 0.0779 0.142
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Plasmodium vivax histone deacetylase 1, putative 0.0195 0.1086 0.1894
Echinococcus granulosus dihydrofolate reductase 0.0044 0.011 0.02
Leishmania major histone deacetylase, putative 0.0151 0.0797 0.3909
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0877 0.5482 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0518 0.0413
Loa Loa (eye worm) hypothetical protein 0.0192 0.1062 0.1937
Echinococcus multilocularis histone deacetylase 0.0151 0.0797 0.1455
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Onchocerca volvulus 0.006 0.0213 0.0348
Loa Loa (eye worm) DR-78 0.009 0.0409 0.0746
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0213 0.036
Echinococcus granulosus neuropeptide receptor 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.009 0.0409 0.0746
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0213 0.036
Loa Loa (eye worm) TK/INSR protein kinase 0.0041 0.009 0.0165
Mycobacterium ulcerans isocitrate lyase AceAb 0.1577 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0101 0.0479 0.0847
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0213 0.0388
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.009 0.0409 0.0708
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0255 0.0465
Echinococcus granulosus serotonin receptor 0.006 0.0213 0.0388
Schistosoma mansoni TRABID protein (C64 family) 0.0312 0.1838 0.3333
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi nuclear hormone receptor family member nhr-6 0.009 0.0409 0.0746
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0192 0.1062 0.1914
Schistosoma mansoni zinc finger protein 0.0312 0.1838 0.3333
Echinococcus granulosus histone deacetylase 3 0.0195 0.1086 0.198
Brugia malayi hypothetical protein 0.0121 0.0607 0.1108
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0213 0.0388
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0213 0.0388
Echinococcus multilocularis histone deacetylase 3 0.0195 0.1086 0.198
Brugia malayi hypothetical protein 0.0051 0.0157 0.0286
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0148 0.0779 0.142
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0062 0.0229 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0192 0.1062 0.1937
Echinococcus granulosus ring and YY1 binding protein 0.0312 0.1838 0.3353
Echinococcus multilocularis histone deacetylase 7 0.0151 0.0797 0.1455
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0148 0.0779 0.142
Toxoplasma gondii histone deacetylase HDAC1 0.0151 0.0797 0.1362
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0312 0.1838 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Trypanosoma cruzi histone deacetylase, putative 0.0078 0.0329 0.1168
Onchocerca volvulus 0.0286 0.1671 0.302
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0877 0.5482 1
Schistosoma mansoni hypothetical protein 0.0877 0.5482 1
Echinococcus granulosus neuropeptide receptor A26 0.006 0.0213 0.0388
Onchocerca volvulus 0.0233 0.133 0.2395
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0192 0.1062 0.1914
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Brugia malayi Dopamine receptor protein 1 0.006 0.0213 0.0388
Echinococcus granulosus histone deacetylase 6 0.0151 0.0797 0.1455
Echinococcus granulosus glycine receptor subunit alpha 1 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Leishmania major hypothetical protein, conserved 0.0312 0.1838 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0312 0.1838 0.3353
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0312 0.1838 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.013 0.0237
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0062 0.0229 0.0418
Brugia malayi nuclear hormone receptor 0.0192 0.1062 0.1937
Trichomonas vaginalis histone deacetylase, putative 0.0195 0.1086 0.1975
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0148 0.0779 0.142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0192 0.1062 0.1914
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0273 0.0499
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.0874
Loa Loa (eye worm) glutathione reductase 0.0047 0.013 0.0237
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0148 0.0779 0.142
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0877 0.5482 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0213 0.0388
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0062 0.0229 0.0418
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi dihydrofolate reductase family protein 0.0044 0.011 0.02
Loa Loa (eye worm) histone deacetylase 0.0151 0.0797 0.1455
Echinococcus multilocularis SWI:SNF matrix associated 0.0877 0.5482 1
Brugia malayi neuropeptide F receptor 0.006 0.0213 0.0388
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0213 0.036
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0148 0.0779 0.142
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0192 0.1062 0.1937
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0213 0.036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0192 0.1062 0.1937
Onchocerca volvulus Histone deacetylase 10 homolog 0.0078 0.0329 0.0562
Brugia malayi chromobox protein homolog 3 0.0039 0.0077 0.014
Schistosoma mansoni histone deacetylase hda2 0.0151 0.0797 0.143
Brugia malayi putative neuropeptide receptor 0.006 0.0213 0.0388
Trypanosoma cruzi histone deacetylase, putative 0.0151 0.0797 0.3909
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0213 0.036
Loa Loa (eye worm) nuclear receptor NHR-67 0.009 0.0409 0.0746
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0192 0.1062 0.1937
Brugia malayi Nuclear hormone receptor E75 0.009 0.0409 0.0746
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0148 0.0779 0.1395
Brugia malayi Thioredoxin reductase 0.0047 0.013 0.0237
Loa Loa (eye worm) hypothetical protein 0.0148 0.0779 0.142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0132 0.0212
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0195 0.1086 0.1975
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0148 0.0779 0.142
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0877 0.5482 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0229 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0213 0.0388
Brugia malayi nuclear receptor RXR 0.0101 0.0479 0.0874
Loa Loa (eye worm) hypothetical protein 0.0312 0.1838 0.3353
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0213 0.0388
Loa Loa (eye worm) hypothetical protein 0.006 0.0213 0.0388
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.1577 1 1
Brugia malayi ORL1-like opioid receptor 0.006 0.0213 0.0388
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.009 0.0409 0.0746
Brugia malayi hypothetical protein 0.006 0.0213 0.0388
Schistosoma mansoni neuropeptide receptor 0.006 0.0213 0.036
Loa Loa (eye worm) nuclear receptor nhr-7B 0.009 0.0409 0.0746
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0192 0.1062 0.1937
Schistosoma mansoni tyrosine kinase 0.0068 0.0265 0.0456
Trypanosoma cruzi hypothetical protein, conserved 0.0312 0.1838 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0213 0.036

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.9 lntrinsic activity of the compound was determined relative to 5-HT receptor ChEMBL. No reference
Activity (functional) = 0.9 lntrinsic activity of the compound was determined relative to 5-HT receptor ChEMBL. No reference
Activity (functional) = 84 % 5-hydroxytryptamine 4 receptor agonist activity is expressed as percent of the maximum 5-HT response ChEMBL. 9046352
Activity (functional) = 84 % 5-hydroxytryptamine 4 receptor agonist activity is expressed as percent of the maximum 5-HT response ChEMBL. 9046352
EC50 (functional) = -6.3 5-hydroxytryptamine 4 receptor agonist activity of the compound was determined in the rat esophageal muscularis mucosae ChEMBL. No reference
EC50 (functional) = 166 nM 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum ChEMBL. 9046352
EC50 (functional) = 166 nM 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum ChEMBL. 9046352
ED50 (binding) = 505 nM Relaxation of carbachol induced contractions of rat tunica muscularis mucosae ChEMBL. 1573641
IC50 (functional) 0 nM 5-hydroxytryptamine 4 receptor antagonist activity as inhibition of 5-HT-induced contractions in guinea pig ileum; Not capable of evaluation. ChEMBL. 9046352
ID50 (functional) = 1 ug kg-1 Antagonism of the bradycardia induced by iv injection of 5-HT(10-30 microg/kg) was evaluated by the compound administration in rat; 0.3-3.4 ChEMBL. No reference
Inhibition (functional) ug kg-1 In vivo 5-hydroxytryptamine 3 receptor antagonist activity of the compound was determined by antagonism of the von Bezold-Jarisch (B-J) reflex in anesthetized rats, (i.v.); Not tested ChEMBL. No reference
Inhibition (functional) 0 ug kg-1 In vivo 5-hydroxytryptamine 3 receptor antagonist activity of the compound was determined by antagonism of the von Bezold-Jarisch (B-J) reflex in anesthetized rats, (i.v.); Not tested ChEMBL. No reference
Intrinsic activity (functional) = 1.9 Compound was evaluated for the relative potency with respect to serotonin against 5-hydroxytryptamine 4 receptor ChEMBL. 7608898
Intrinsic activity (functional) = 1.9 Compound was evaluated for the relative potency with respect to serotonin against 5-hydroxytryptamine 4 receptor ChEMBL. 7608898
Ki (binding) = -8.5 Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]-quipazine ChEMBL. 8410977
Ki (binding) = -8.5 Binding affinity of the compound to 5-hydroxytryptamine 3 receptor was determined in rat cerebro cortical membranes using [3H]-quipazine. ChEMBL. No reference
Ki (binding) = -8.43 Binding affinity of the compound for 5-hydroxytryptamine 3 receptor by displacement of racemic [3H]-zacopride from rat cortex ChEMBL. No reference
Ki (binding) = -8.3 Binding affinity of the compound for 5-hydroxytryptamine 3 receptor by displacement of [3H]-(R)-zacopride from ondansetron-treated NG-108-15 cell membranes ChEMBL. No reference
Ki (binding) = -5.55 Binding affinity of the compound for 5-hydroxytryptamine 4 receptor by displacement of [3H]-GR 113808 from guinea pig brain striatum. ChEMBL. No reference
Ki (binding) = 2.6 nM Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement. ChEMBL. No reference
Ki (binding) = 2.6 nM Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement. ChEMBL. No reference
Ki (binding) = 2.6 nM Binding affinity of the compound to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand ChEMBL. No reference
Ki (binding) = 2.6 nM Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement. ChEMBL. No reference
Ki (binding) = 2.6 nM Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement. ChEMBL. No reference
Ki (binding) = 8 nM Inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor ChEMBL. 1573641
Ki (binding) = 9.5 nM Compound was evaluated for the binding affinity at 5- HT3 receptor ChEMBL. 7608898
Ki (binding) = 9.5 nM Compound was evaluated for the binding affinity at 5- HT3 receptor ChEMBL. 7608898
Ki (binding) = 415 nM The ability of the compound to inhibit [3H]-ketanserin binding to 5-hydroxytryptamine 2 receptor in rat whole brain ChEMBL. 1573641
Ki (binding) = 1510 nM Binding affinity of the compound towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]-GR-113,808 as radioligand ChEMBL. 9046352
Ki (binding) = 1510 nM Binding affinity of the compound towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]-GR-113,808 as radioligand ChEMBL. 9046352
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-5-HT binding to 5-hydroxytryptamine 1 receptor in rat cortex ChEMBL. 1573641
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata ChEMBL. 1573641
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-domperidone binding to dopamine receptor D2 in rat striata ChEMBL. 1573641
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-prazosin binding to Alpha-1 adrenergic receptor in rat whole brain ChEMBL. 1573641
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-rauwolscine binding to alpha-2 adrenergic receptor in rat cortex ChEMBL. 1573641
Ki (binding) > 10000 nM The ability of the compound to inhibit [3H]-dihydroalprenolol prenolol binding to Beta adrenergic receptor in rat whole brain ChEMBL. 1573641
Log EC50 (functional) = 6.3 5-hydroxytryptamine 4 receptor agonist activity of the compound was determined in the rat esophageal muscularis mucosae ChEMBL. No reference
Log Ki (binding) = 5.55 Binding affinity of the compound for 5-hydroxytryptamine 4 receptor by displacement of [3H]-GR 113808 from guinea pig brain striatum. ChEMBL. No reference
Log Ki (binding) = 8.3 Binding affinity of the compound for 5-hydroxytryptamine 3 receptor by displacement of [3H]-(R)-zacopride from ondansetron-treated NG-108-15 cell membranes ChEMBL. No reference
Log Ki (binding) = 8.43 Binding affinity of the compound for 5-hydroxytryptamine 3 receptor by displacement of racemic [3H]-zacopride from rat cortex ChEMBL. No reference
Log Ki (binding) = 8.5 Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]-quipazine ChEMBL. 8410977
Log Ki (binding) = 8.5 Binding affinity of the compound to 5-hydroxytryptamine 3 receptor was determined in rat cerebro cortical membranes using [3H]-quipazine. ChEMBL. No reference
pD2 (functional) = 6.8 5-hydroxytryptamine 4 receptor agonist activity of the compound in the guinea pig ileum assay ChEMBL. 7608898
pD2 (functional) = 6.8 5-hydroxytryptamine 4 receptor agonist activity of the compound in the guinea pig ileum assay ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Alpha-1 adrenergic receptor in calf cortex by displacing prazosin ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Dopamine receptor D1 agonism in the calf striatum by displacing SCH 23390 ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by 5-hydroxytryptamine 2A receptor agonism in the rat cortex by displacing ketanserin ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Dopamine receptor D2 agonism in the calf striatum by displacing spiperone ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by 5-hydroxytryptamine 1A receptor agonism in the pig cortex by displacing 8-OH-DPAT ChEMBL. 7608898
pKD (binding) = 9.5 Binding affinity was evaluated by 5-hydroxytryptamine 3 receptor agonism in the mouse NIE-115 by displacing tropisetron ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by 5-hydroxytryptamine 1A receptor agonism in the pig cortex by displacing 8-OH-DPAT ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by 5-hydroxytryptamine 2A receptor agonism in the rat cortex by displacing ketanserin ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Dopamine receptor D1 agonism in the calf striatum by displacing SCH 23390 ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Dopamine receptor D2 agonism in the calf striatum by displacing spiperone ChEMBL. 7608898
pKD (binding) < 5 Binding affinity was evaluated by Alpha-1 adrenergic receptor in calf cortex by displacing prazosin ChEMBL. 7608898
pKD (binding) = 9.5 Binding affinity was evaluated by 5-hydroxytryptamine 3 receptor agonism in the mouse NIE-115 by displacing tropisetron ChEMBL. 7608898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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