Detailed information for compound 413697

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 517.49 | Formula: C27H34Cl2N4O2
  • H donors: 2 H acceptors: 2 LogP: 5.37 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCCN(CC1)C(=O)Nc1ccc(cc1)C
  • InChi: 1S/C27H34Cl2N4O2/c1-21-6-10-23(11-7-21)31-27(35)33-17-5-16-32(18-19-33)15-4-2-3-14-30-26(34)13-9-22-8-12-24(28)25(29)20-22/h6-13,20H,2-5,14-19H2,1H3,(H,30,34)(H,31,35)/b13-9+
  • InChiKey: VOVWYRPVUVLZTL-UKTHLTGXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0119 0.0502 0.0806
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0166 0.1017 0.4303
Schistosoma mansoni tyrosine kinase 0.0364 0.3144 0.537
Echinococcus multilocularis casein kinase I gamma 0.0226 0.1664 0.1864
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.1102 0.1843
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Onchocerca volvulus 0.0136 0.069 0.2033
Plasmodium falciparum protein kinase, putative 0.011 0.0414 0.3857
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0518 0.0834
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Giardia lamblia Kinase, CMGC CK2 0.0106 0.037 0.147
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.013 0.0623 0.2579
Onchocerca volvulus 0.0119 0.0502 0.1448
Echinococcus granulosus rho-associated protein kinase 1 0.0345 0.2944 0.5054
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0077 0.0058 0.0099
Echinococcus granulosus c src tyrosine kinase 0.018 0.116 0.1992
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0458 0.4161 0.4659
Echinococcus granulosus dual specificity 0.0148 0.0815 0.1399
Trichomonas vaginalis STE family protein kinase 0.0145 0.0782 0.2681
Loa Loa (eye worm) TK/FAK protein kinase 0.0619 0.5894 0.5879
Echinococcus multilocularis Glutaredoxin protein 5 0.0131 0.0638 0.0715
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0374 0.3258 0.3235
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0273 0.2163 0.2136
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Echinococcus multilocularis epidermal growth factor receptor 0.0392 0.3444 0.3857
Echinococcus multilocularis rho associated protein kinase 0.0345 0.2944 0.3297
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.1767 0.2991
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0089 0.0183 0.0531
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0281 0.2253 0.2523
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0374 0.3258 0.5593
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0671 0.228
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0088 0.0176 0.0505
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0236 0.1767 0.1738
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Loa Loa (eye worm) hypothetical protein 0.0192 0.1289 0.1259
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0075 0.0035 0.006
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.038 0.3324 0.3722
Entamoeba histolytica cell division protein kinase 2, putative 0.0126 0.0584 0.1553
Plasmodium falciparum protein kinase 5 0.0126 0.0584 0.5594
Echinococcus multilocularis tyrosine protein kinase Srms 0.0229 0.1696 0.19
Echinococcus multilocularis nervana 2 0.0131 0.0638 0.0715
Loa Loa (eye worm) hypothetical protein 0.049 0.4502 0.4482
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0215 0.1543 0.1728
Loa Loa (eye worm) TK protein kinase 0.0083 0.0119 0.0085
Echinococcus granulosus N chimaerin 0.0105 0.0357 0.0613
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.012 0.0518 0.1799
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0119 0.0502 0.2046
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0273 0.2166 0.2426
Plasmodium vivax serine/threonine kinase-1, putative 0.0163 0.0983 0.9652
Echinococcus multilocularis cyclin dependent kinase 0.0126 0.0584 0.0654
Trichomonas vaginalis CMGC family protein kinase 0.0126 0.0584 0.197
Entamoeba histolytica protein kinase, putative 0.0076 0.0038 0.001
Brugia malayi Protein kinase domain containing protein 0.033 0.2778 0.2752
Echinococcus granulosus natriuretic peptide receptor 1 0.0075 0.0035 0.006
Echinococcus multilocularis tyrosine protein kinase csk 0.0075 0.0035 0.0039
Echinococcus granulosus cGMP dependent protein kinase 1 0.0143 0.0765 0.1313
Echinococcus granulosus cGMP dependent protein kinase 1 0.0143 0.0765 0.1313
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0157 0.0211
Onchocerca volvulus Serine\/threonine kinase homolog 0.0174 0.1102 0.3311
Brugia malayi casein kinase 1, delta 0.0115 0.0468 0.0435
Loa Loa (eye worm) hypothetical protein 0.0147 0.0811 0.0779
Schistosoma mansoni serine/threonine protein kinase 0.025 0.1913 0.3244
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0085 0.0139 0.0156
Brugia malayi Serine/threonine-protein kinase SULU 0.0236 0.1767 0.1738
Echinococcus granulosus NCK adaptor protein 0.0104 0.0349 0.0599
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0353 0.3034 0.3009
Echinococcus granulosus kinase suppressor of Ras 1 0.0075 0.0035 0.006
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0273 0.2166 0.3719
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0119 0.0502 0.0562
Entamoeba histolytica cell division protein kinase 2, putative 0.0126 0.0584 0.1553
Echinococcus multilocularis tyrosine kinase 0.0075 0.0035 0.0039
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0236 0.1767 0.3033
Trichomonas vaginalis AGC family protein kinase 0.0193 0.1307 0.456
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0379 0.0594
Echinococcus multilocularis heat shock protein 70 0.0075 0.0035 0.0039
Echinococcus granulosus fibroblast growth factor receptor 4 0.0075 0.0035 0.006
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.012 0.0518 0.2117
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0389 0.342 0.3831
Brugia malayi Protein kinase domain containing protein 0.0237 0.1774 0.1746
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.009 0.0194 0.0695
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0461 0.4189 0.7191
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0273 0.2166 0.2426
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0169 0.1045 0.4428
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0075 0.0035 0.006
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0137 0.0697 0.2902
Brugia malayi Protein kinase domain containing protein 0.0213 0.1522 0.1492
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.062 0.1656
Echinococcus granulosus protein kinase 0.0075 0.0035 0.006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0083 0.0119 0.0085
Echinococcus granulosus casein kinase I alpha 0.0115 0.0468 0.0804
Echinococcus multilocularis tyrosine protein kinase Blk 0.0229 0.1696 0.19
Schistosoma mansoni serine/threonine protein kinase 0.0331 0.279 0.4758
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.023 0.1707 0.5997
Brugia malayi Variant SH3 domain containing protein 0.0105 0.0357 0.0323
Leishmania major protein kinase, putative 0.0155 0.0889 0.3744
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Entamoeba histolytica protein kinase, putative 0.0075 0.0036 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0075 0.0035 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0107 0.0379 0.3501
Echinococcus multilocularis protein kinase c epsilon type 0.0239 0.1799 0.2015
Loa Loa (eye worm) hypothetical protein 0.0152 0.0857 0.0825
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.018 0.116 0.1943
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0273 0.2166 0.2426
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0075 0.0035 0.006
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0163 0.0983 0.4153
Brugia malayi Protein kinase domain containing protein 0.0136 0.069 0.0658
Echinococcus multilocularis protein KINase family member (kin 25) 0.0075 0.0035 0.0039
Echinococcus multilocularis tyrosine kinase 0.0136 0.069 0.0773
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0283 0.2269 0.2242
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0889 0.3064
Brugia malayi Protein kinase domain containing protein 0.0136 0.069 0.0658
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0091 0.0209 0.0359
Entamoeba histolytica casein kinase, putative 0.0115 0.0468 0.1225
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0075 0.0035 0.0039
Echinococcus multilocularis serine:threonine protein kinase 3 0.0273 0.2163 0.2422
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0252 0.0778
Giardia lamblia Kinase, CDC7 0.0095 0.0252 0.0951
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0183 0.0649
Onchocerca volvulus 0.0345 0.2944 0.9026
Echinococcus granulosus tyrosine protein kinase ABL1 0.0356 0.3063 0.5258
Loa Loa (eye worm) hypothetical protein 0.0121 0.0531 0.0497
Echinococcus granulosus serine:threonine kinase SAD 1 0.0095 0.0248 0.0425
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0089 0.0183 0.0649
Echinococcus multilocularis aurora kinase A 0.0155 0.0889 0.0996
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0091 0.0209 0.0234
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0382 0.3337 0.3313
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.2944 0.5025
Echinococcus granulosus mitogen activated protein kinase 11 0.0169 0.1045 0.1795
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0237 0.1774 0.1746
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Brugia malayi Protein kinase domain containing protein 0.0088 0.0176 0.0141
Brugia malayi Protein kinase domain containing protein 0.0087 0.0157 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0513 0.0826
Entamoeba histolytica protein kinase, putative 0.0075 0.0036 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0889 0.3064
Entamoeba histolytica protein kinase, putative 0.0078 0.0063 0.008
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0075 0.0035 0.0039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0273 0.2166 0.2426
Echinococcus granulosus protein tyrosine kinase 0.0612 0.5825 0.9999
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0353 0.3034 0.3009
Plasmodium vivax unspecified product 0.0106 0.037 0.3416
Echinococcus multilocularis tyrosine protein kinase csk 0.0075 0.0035 0.0039
Plasmodium falciparum serine/threonine protein kinase KIN 0.0095 0.0248 0.2168
Schistosoma mansoni tyrosine kinase 0.0316 0.2632 0.4486
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Echinococcus multilocularis expressed protein 0.0088 0.0176 0.0197
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0095 0.0248 0.0933
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.012 0.0518 0.1733
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0889 0.3064
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0107 0.0379 0.128
Echinococcus granulosus casein kinase I alpha 0.0115 0.0468 0.0804
Loa Loa (eye worm) hypothetical protein 0.0341 0.2894 0.2869
Trichomonas vaginalis STE family protein kinase 0.0091 0.0209 0.0625
Entamoeba histolytica protein kinase domain containing protein 0.0148 0.0815 0.2206
Echinococcus multilocularis serine threonine protein kinase 0.0237 0.1775 0.1987
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Plasmodium falciparum calcium-dependent protein kinase 2 0.0107 0.0379 0.3501
Plasmodium vivax protein kinase Crk2 0.0126 0.0584 0.5594
Leishmania major protein kinase, putative 0.0107 0.0379 0.1507
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0148 0.0815 0.0783
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0155 0.0889 0.1527
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0148 0.0815 0.2797
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0174 0.1102 0.1892
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0154 0.088 0.0986
Entamoeba histolytica protein kinase, putative 0.0091 0.0209 0.0492
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0115 0.0468 0.0435
Onchocerca volvulus 0.008 0.0089 0.0169
Leishmania major protein kinase, putative 0.0163 0.0983 0.4153
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.013 0.0623 0.2111
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0148 0.0815 0.3418
Echinococcus granulosus serine:threonine protein kinase N2 0.0331 0.279 0.4789
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.013 0.0623 0.2579
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0213 0.1522 0.1492
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Brugia malayi protein kinase C II. 0.0239 0.1799 0.1771
Echinococcus granulosus dual specificity 0.013 0.0623 0.107
Echinococcus multilocularis activated cdc42 kinase 1 0.0075 0.0035 0.0039
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0087 0.0157 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus granulosus retinal guanylyl cyclase 2 0.0075 0.0035 0.006
Plasmodium falciparum serine/threonine protein kinase, putative 0.0155 0.0889 0.8702
Echinococcus multilocularis tyrosine protein kinase 0.033 0.2778 0.3111
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Loa Loa (eye worm) TK/INSR protein kinase 0.0364 0.3144 0.312
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0239 0.1799 0.1771
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Loa Loa (eye worm) TK protein kinase 0.0397 0.3505 0.3483
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0166 0.1017 1
Echinococcus granulosus protein kinase c epsilon type 0.0239 0.1799 0.3089
Plasmodium vivax protein kinase, putative 0.0091 0.0207 0.1757
Loa Loa (eye worm) hypothetical protein 0.0104 0.0349 0.0315
Entamoeba histolytica protein kinase, putative 0.0078 0.0063 0.008
Brugia malayi STE20-like kinase MST 0.0273 0.2163 0.2136
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0252 0.0778
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0157 0.0438
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0137 0.0697 0.1143
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0075 0.0035 0.006
Schistosoma mansoni protein kinase 0.0461 0.4189 0.7174
Plasmodium falciparum calcium-dependent protein kinase 3 0.0107 0.0379 0.3501
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Loa Loa (eye worm) protein kinase domain-containing protein 0.0226 0.1664 0.1635
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0815 0.1347
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0075 0.0035 0.006
Entamoeba histolytica protein kinase, putative 0.0334 0.2823 0.7886
Giardia lamblia Kinase, STE STE20 0.009 0.0194 0.0695
Echinococcus granulosus growth factor receptor bound protein 2 0.0107 0.0372 0.0638
Echinococcus granulosus insulin receptor 0.0364 0.3144 0.5398
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0095 0.0248 0.0933
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0461 0.4189 0.4691
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0096 0.0257 0.0629
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0143 0.0765 0.0856
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0148 0.0815 0.2904
Brugia malayi hypothetical protein 0.0119 0.0502 0.0468
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.0889
Echinococcus multilocularis NCK adaptor protein 0.0107 0.0372 0.0416
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0389 0.342 0.3397
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0119 0.0502 0.0806
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1522 0.2568
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.0518 0.0485
Onchocerca volvulus 0.0137 0.0697 0.2054
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0085 0.0139 0.0239
Brugia malayi intracellular kinase 0.0137 0.0697 0.0664
Schistosoma mansoni protein kinase 0.0205 0.1431 0.2411
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Echinococcus granulosus retinal guanylyl cyclase 2 0.0075 0.0035 0.006
Echinococcus multilocularis mitogen activated protein kinase 14 0.0169 0.1045 0.1171
Brugia malayi Protein kinase domain 0.0091 0.0209 0.0175
Echinococcus multilocularis mitogen activated protein kinase 14 0.0169 0.1045 0.1171
Loa Loa (eye worm) TK/EGFR protein kinase 0.0612 0.5825 0.5811
Schistosoma mansoni growth factor receptor-bound protein 0.0104 0.0349 0.0542
Schistosoma mansoni tyrosine kinase 0.0302 0.2477 0.4218
Schistosoma mansoni protein kinase C mu 0.0231 0.1714 0.2901
Trypanosoma cruzi casein kinase, delta isoform, putative 0.008 0.0089 0.0239
Echinococcus granulosus ephrin type A receptor 4 A 0.0143 0.0767 0.1317
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0476 0.4356 0.4336
Brugia malayi Protein kinase domain containing protein 0.0205 0.1431 0.1401
Brugia malayi Egg laying defective protein 4 0.0143 0.0765 0.0732
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0104 0.0349 0.0315
Entamoeba histolytica protein kinase, putative 0.013 0.0623 0.1664
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0281 0.2248 0.2518
Entamoeba histolytica p21-activated kinase 0.0101 0.0311 0.0782
Entamoeba histolytica protein kinase, putative 0.0137 0.0697 0.1872
Schistosoma mansoni serine/threonine kinase 0.0193 0.1307 0.2196
Giardia lamblia Kinase, CMGC CDK 0.0126 0.0584 0.2407
Brugia malayi map kinase activated protein kinase protein 2 0.0419 0.3734 0.3712
Echinococcus multilocularis serine:threonine protein kinase N2 0.0138 0.0707 0.0791
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0273 0.2166 0.2426
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.0889 0.2416
Giardia lamblia Kinase, STE STE20 0.0091 0.0209 0.0763
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0229 0.1696 0.19
Echinococcus granulosus retinal guanylyl cyclase 2 0.0075 0.0035 0.006
Echinococcus multilocularis mitogen activated protein kinase 3 0.0089 0.0183 0.0205
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0131 0.0638 0.1095
Echinococcus granulosus serine/threonine protein kinase 0.0176 0.1119 0.1921
Echinococcus multilocularis kinase suppressor of Ras 1 0.0075 0.0035 0.0039
Echinococcus granulosus aurora kinase A 0.0155 0.0889 0.1527
Loa Loa (eye worm) hypothetical protein 0.0205 0.1438 0.1408
Echinococcus granulosus tyrosine protein kinase Src64B 0.0273 0.2166 0.3719
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Trypanosoma brucei protein kinase, putative 0.0137 0.0697 0.2374
Trypanosoma cruzi cdc2-related kinase 1 0.0126 0.0584 0.2407
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0088 0.0176 0.0141
Schistosoma mansoni tyrosine kinase 0.0421 0.3764 0.6441
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0379 0.0424
Echinococcus multilocularis nervana 2 0.0131 0.0638 0.0715
Brugia malayi Protein kinase domain containing protein 0.0226 0.1664 0.1635
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0089 0.0183 0.0149
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0137 0.0697 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Entamoeba histolytica protein kinase, putative 0.0325 0.2721 0.7597
Loa Loa (eye worm) TK/ROR protein kinase 0.0083 0.0119 0.0085
Brugia malayi hypothetical protein 0.0136 0.069 0.0658
Echinococcus multilocularis c src tyrosine kinase 0.018 0.116 0.1299
Brugia malayi Protein kinase domain containing protein 0.0126 0.0584 0.0551
Echinococcus granulosus Protein kinase C brain isozyme 0.0281 0.2253 0.3868
Brugia malayi Protein kinase domain containing protein 0.0619 0.5894 0.5879
Echinococcus granulosus dual specificity 0.0148 0.0815 0.1399
Trypanosoma cruzi casein kinase, putative 0.0115 0.0468 0.1898
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Toxoplasma gondii AGC kinase 0.012 0.0518 0.1799
Brugia malayi SRC-1 0.0273 0.2166 0.2139
Echinococcus granulosus casein kinase I gamma 0.0226 0.1664 0.2857
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0163 0.0983 0.3528
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0229 0.1696 0.2912
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0163 0.0983 0.3399
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0183 0.0531
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0468 0.0748
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Giardia lamblia Kinase, CMGC DYRK 0.0148 0.0815 0.3418
Echinococcus granulosus cyclin dependent kinase 0.0126 0.0584 0.1003
Schistosoma mansoni vam6/vps39 related 0.0119 0.0502 0.0806
Schistosoma mansoni protein kinase 0.0461 0.4189 0.7174
Trichomonas vaginalis CMGC family protein kinase 0.0126 0.0584 0.197
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0765 0.1261
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.058
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0518 0.0834
Loa Loa (eye worm) TK/ABL protein kinase 0.0356 0.3063 0.3038
Loa Loa (eye worm) hypothetical protein 0.0159 0.0942 0.091
Trypanosoma cruzi Protein kinase B 0.0176 0.1119 0.4751
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0374 0.3258 0.3649
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Brugia malayi Cam kinase protein 1 0.0107 0.0379 0.0345
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0374 0.3258 0.3235
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0468 0.0524
Schistosoma mansoni tyrosine kinase 0.0392 0.3444 0.5887
Echinococcus multilocularis insulin receptor 0.0364 0.3144 0.3521
Schistosoma mansoni atypical protein kinase C 0.0332 0.2803 0.478
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.135 0.2272
Trichomonas vaginalis STE family protein kinase 0.0091 0.0209 0.0625
Mycobacterium ulcerans hypothetical protein 0.0108 0.0386 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0075 0.0035 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Entamoeba histolytica protein kinase, putative 0.0193 0.1307 0.3596
Brugia malayi RhoGAP domain containing protein 0.0105 0.0357 0.0323
Trypanosoma cruzi cdc2-related kinase 1 0.0126 0.0584 0.2407
Brugia malayi Protein kinase domain containing protein 0.0193 0.1307 0.1276
Loa Loa (eye worm) TK/EPH protein kinase 0.0162 0.0968 0.0936
Brugia malayi Protein kinase domain containing protein 0.0174 0.1102 0.1071
Schistosoma mansoni tyrosine kinase 0.0364 0.3144 0.537
Trichomonas vaginalis CMGC family protein kinase 0.0163 0.0983 0.3399
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Loa Loa (eye worm) hypothetical protein 0.0126 0.0584 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0864 0.1431
Brugia malayi Protein kinase domain containing protein 0.0095 0.0252 0.0218
Echinococcus granulosus epidermal growth factor receptor 0.0612 0.5825 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0458 0.4161 0.7142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0137 0.0697 0.0664
Loa Loa (eye worm) hypothetical protein 0.0095 0.0248 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0048 0.0047
Loa Loa (eye worm) TK protein kinase 0.033 0.2778 0.2752
Echinococcus multilocularis dual specificity testis specific protein kinase 0.011 0.0414 0.0463
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0197 0.135 0.1512
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0079 0.007 0.0035
Echinococcus granulosus activin receptor type 0.011 0.0414 0.071
Giardia lamblia Kinase, PLK 0.0287 0.2317 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0287 0.2317 1
Schistosoma mansoni serine/threonine kinase 0.023 0.1707 0.2888
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0229 0.1696 0.2911
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Schistosoma mansoni tyrosine kinase 0.0273 0.2166 0.3681
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Onchocerca volvulus 0.0205 0.1438 0.4353
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0107 0.0379 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Onchocerca volvulus 0.0152 0.0857 0.2552
Entamoeba histolytica protein kinase domain containing protein 0.0215 0.1543 0.4265
Leishmania major casein kinase, putative 0.0115 0.0468 0.1898
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.011 0.0414 0.166
Trypanosoma brucei protein kinase, putative 0.0089 0.0183 0.0531
Echinococcus multilocularis mitogen activated protein kinase 0.0089 0.0183 0.0205
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1 1 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0087 0.0157 0.0123
Entamoeba histolytica protein kinase, putative 0.0088 0.0176 0.0398
Brugia malayi protein-tyrosine kinase 0.0229 0.1696 0.1667
Leishmania major protein kinase, putative 0.0163 0.0983 0.4153
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.012 0.0518 0.4921
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0248 0.0368
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0086 0.0152 0.1191
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1696 0.2869
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0087 0.0157 0.0123
Schistosoma mansoni protein kinase 0.0461 0.4189 0.7174
Schistosoma mansoni protein kinase 0.011 0.0414 0.0654
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.0518 0.2117
Onchocerca volvulus 0.0136 0.069 0.2033
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0283 0.2269 0.3895
Trypanosoma cruzi casein kinase, putative 0.0115 0.0468 0.1898
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0107 0.0379 0.0345
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0095 0.0248 0.0214
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0137 0.0697 0.1197
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0379 0.0424
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Entamoeba histolytica serine/threonine protein kinase, putative 0.0287 0.2317 0.6453
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0137 0.0697 0.2902
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2253 0.3831
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.009 0.0194 0.0569
Echinococcus multilocularis 0.0128 0.0604 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0048 0.0047
Echinococcus granulosus serine:threonine protein kinase 3 0.0273 0.2163 0.3713
Brugia malayi Protein kinase domain containing protein 0.0136 0.069 0.0658
Echinococcus granulosus dual specificity 0.0148 0.0815 0.1399
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0155 0.0889 0.2416
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.1799 0.3047
Loa Loa (eye worm) hypothetical protein 0.0196 0.1336 0.1305
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0145 0.0782 0.7614
Trypanosoma cruzi aurora B kinase, putative 0.0155 0.0889 0.3744
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0163 0.0983 0.4153
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0091 0.0209 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.0815 0.2797
Brugia malayi Immunoglobulin I-set domain containing protein 0.0084 0.0124 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0215 0.1543 0.1513
Trypanosoma cruzi polo-like protein kinase, putative 0.0287 0.2317 1
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0765 0.1261
Entamoeba histolytica protein kinase, putative 0.0334 0.2823 0.7886
Brugia malayi p70 ribosomal S6 kinase beta 0.0325 0.2721 0.2696
Entamoeba histolytica hypothetical protein 0.0403 0.3571 1
Loa Loa (eye worm) thyroid receptor interactor 0.0124 0.0562 0.0529
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Schistosoma mansoni protein kinase 0.0163 0.0977 0.1627
Trypanosoma brucei SNF1-related protein kinases, putative 0.0095 0.0248 0.0764
Entamoeba histolytica PH domain containing protein kinase, putative 0.013 0.062 0.1656
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.0518 0.4921
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0088 0.0176 0.0617
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0281 0.2248 0.2221
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0248 0.0368
Brugia malayi MAP kinase sur-1 0.0089 0.0183 0.0149
Echinococcus granulosus nervana 2 0.0131 0.0638 0.1095
Onchocerca volvulus 0.0136 0.069 0.2033
Schistosoma mansoni ephrin receptor 0.0143 0.0767 0.1265
Echinococcus multilocularis tyrosine protein kinase csk 0.0075 0.0035 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Echinococcus multilocularis hypothetical protein 0.0108 0.0389 0.0436
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0202 0.1396 0.488
Brugia malayi P38 map kinase family protein 2 0.0169 0.1045 0.1014
Onchocerca volvulus 0.0196 0.1336 0.4036
Entamoeba histolytica casein kinase 1, putative 0.0115 0.0468 0.1225
Echinococcus multilocularis receptor type guanylyl cyclase 0.0075 0.0035 0.0039
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0079 0.007 0.0126
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0143 0.0765 0.0856
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0155 0.0889 0.8702
Giardia lamblia Kinase, CMGC MAPK 0.0089 0.0183 0.0649
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.009 0.0194 0.0695
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0095 0.0248 0.0764
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0107 0.0379 0.128
Trypanosoma cruzi casein kinase, putative 0.0115 0.0468 0.1898
Entamoeba histolytica protein kinase, putative 0.0087 0.0157 0.0346
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Loa Loa (eye worm) AGC/AKT protein kinase 0.0334 0.2823 0.2798
Brugia malayi serine/threonine-protein kinase 6 0.0155 0.0889 0.0857
Trichomonas vaginalis CMGC family protein kinase 0.0126 0.0584 0.197
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0768 0.1265
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0105 0.0357 0.0323
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0089 0.0183 0.0649
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0697 0.2374
Onchocerca volvulus 0.0147 0.0811 0.2408
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0983 0.1637
Echinococcus granulosus mitogen activated protein kinase 14 0.0169 0.1045 0.1795
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0089 0.0183 0.0649
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.011 0.0414 0.1358
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus multilocularis protein kinase shaggy 0.0137 0.0697 0.0781
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0163 0.0983 0.3399
Trichomonas vaginalis CAMK family protein kinase 0.0121 0.0531 0.1777
Brugia malayi Protein kinase c protein 2 0.0123 0.0549 0.0516
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0087 0.0157 0.027
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0105 0.0357 0.0613
Trichomonas vaginalis CMGC family protein kinase 0.0137 0.0697 0.2374
Echinococcus granulosus hypothetical protein 0.0128 0.0604 0.1037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0273 0.2166 0.2426
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0229 0.1696 0.1899
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0089 0.0183 0.0551
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0163 0.0983 0.0951
Echinococcus multilocularis casein kinase I delta 0.0115 0.0468 0.0524
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0091 0.0209 0.0359
Echinococcus granulosus tyrosine protein kinase Srms 0.0569 0.5354 0.9191
Trypanosoma cruzi cdc2-related kinase 3 0.0126 0.0584 0.2407
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.0518 0.2117
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0126 0.0584 0.1003
Loa Loa (eye worm) hypothetical protein 0.0246 0.1877 0.1848
Echinococcus granulosus Vam6:Vps39 protein 0.0119 0.0502 0.0861
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0121 0.0531 0.0497
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0075 0.0036 0.0061
Loa Loa (eye worm) hypothetical protein 0.0095 0.0245 0.0211
Brugia malayi Protein kinase domain containing protein 0.0637 0.6089 0.6075
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus granulosus CDC7 cell division cycle 7 0.0095 0.0252 0.0433
Echinococcus multilocularis N chimaerin 0.0105 0.0357 0.04
Echinococcus multilocularis dual specificity 0.0148 0.0815 0.0913
Entamoeba histolytica protein kinase, putative 0.0107 0.0379 0.0972
Echinococcus multilocularis CDC7 cell division cycle 7 0.0095 0.0252 0.0282
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0174 0.1099 0.1067
Echinococcus granulosus tyrosine kinase 0.0075 0.0035 0.006
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0075 0.0035 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus granulosus tyrosine protein kinase 0.033 0.2778 0.4768
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0154 0.088 0.1511
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0183 0.0531
Giardia lamblia Kinase, CAMK CAMKL 0.0095 0.0248 0.0933
Echinococcus granulosus casein kinase i 0.0115 0.0468 0.0804
Brugia malayi Temporarily assigned gene name protein 59 0.0119 0.0502 0.0468
Echinococcus granulosus activated cdc42 kinase 1 0.0075 0.0035 0.006
Echinococcus granulosus calcium activated potassium channel 0.0143 0.0768 0.1318
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0246 0.1877 0.3221
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.2269 0.3858
Loa Loa (eye worm) hypothetical protein 0.012 0.0518 0.0485
Echinococcus granulosus tyrosine protein kinase Blk 0.0229 0.1696 0.2912
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0115 0.0468 0.0435
Brugia malayi Protein kinase domain containing protein 0.0136 0.069 0.0658
Loa Loa (eye worm) hypothetical protein 0.0136 0.069 0.0658
Echinococcus multilocularis serine:threonine protein kinase 0.0121 0.0531 0.0594
Leishmania major protein kinase A catalytic subunit isoform 1 0.012 0.0518 0.2117
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0107 0.0379 0.3501
Echinococcus granulosus tyrosine protein kinase Fyn 0.0273 0.2166 0.3719
Trichomonas vaginalis TKL family protein kinase 0.0077 0.0048 0.0047
Echinococcus multilocularis dual specificity 0.013 0.0623 0.0698
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0392 0.3444 0.5912
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Entamoeba histolytica protein kinase 2, putative 0.0166 0.1017 0.2777
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0137 0.0697 0.0781
Brugia malayi Variant SH3 domain containing protein 0.0104 0.0349 0.0315
Brugia malayi Variant SH3 domain containing protein 0.0104 0.0349 0.0315
Loa Loa (eye worm) hypothetical protein 0.0254 0.1966 0.1938
Echinococcus granulosus c-Jun N-terminal kinases 0.0281 0.2248 0.3859
Echinococcus granulosus casein kinase I alpha 0.0115 0.0468 0.0804
Schistosoma mansoni kinase 0.0307 0.2528 0.4305
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0075 0.0035 0.0039
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0229 0.1696 0.2911
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0115 0.0468 0.0435
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0105 0.0357 0.0556
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0091 0.0209 0.0234
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0107 0.0379 0.128
Schistosoma mansoni hypothetical protein 0.0108 0.0389 0.0611
Echinococcus multilocularis ephrin type A receptor 4 A 0.0143 0.0767 0.0859
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0154 0.0882 0.1514
Echinococcus granulosus tyrosine protein kinase shark 0.0363 0.3132 0.5377
Loa Loa (eye worm) hypothetical protein 0.0095 0.0245 0.0211
Brugia malayi Protein kinase domain containing protein 0.0389 0.342 0.3397
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0095 0.0248 0.2168
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Schistosoma mansoni tyrosine kinase 0.0612 0.5825 1
Brugia malayi C1-like domain containing protein 0.0231 0.1714 0.1685
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0197 0.135 0.132
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0782 0.2681
Echinococcus multilocularis serine:threonine protein kinase N2 0.0331 0.279 0.3124
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0091 0.0209 0.0359
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0104 0.0349 0.0315
Echinococcus granulosus nervana 2 0.0131 0.0638 0.1095
Entamoeba histolytica protein kinase, putative 0.0155 0.0889 0.2416
Brugia malayi serine/threonine-protein kinase plk-2 0.0287 0.2317 0.229
Echinococcus multilocularis protein tyrosine kinase 0.0612 0.5825 0.6523
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0106 0.037 0.0337
Brugia malayi Hr1 repeat family protein 0.0331 0.279 0.2764
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0169 0.1045 0.4428
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.009 0.0194 0.0449
Trichomonas vaginalis STE family protein kinase 0.0091 0.0209 0.0625
Trichomonas vaginalis STE family protein kinase 0.0091 0.0209 0.0625
Entamoeba histolytica protein kinase , putative 0.0155 0.0889 0.2416
Entamoeba histolytica hypothetical protein 0.013 0.0623 0.1664
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0215 0.1543 0.1513
Brugia malayi Furin-like cysteine rich region family protein 0.0612 0.5825 0.5811
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0107 0.0379 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0518 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2248 0.3822
Brugia malayi Protein kinase domain containing protein 0.0374 0.3258 0.3235
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0107 0.0379 0.0345
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0623 0.1016
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0131 0.0638 0.0715
Toxoplasma gondii casein kinase I 0.0115 0.0468 0.1613
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0231 0.1714 0.1685
Giardia lamblia Kinase, AGC AKT 0.0124 0.0564 0.232
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0166 0.1017 0.1746
Loa Loa (eye worm) hypothetical protein 0.0383 0.3349 0.3326
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0137 0.0697 0.2465
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0287 0.2317 0.2595
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0379 0.1233
Loa Loa (eye worm) TK protein kinase 0.0229 0.1696 0.1667
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0105 0.0357 0.04
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0086 0.0152 0.0435
Echinococcus multilocularis epidermal growth factor receptor 0.0612 0.5825 0.6523
Schistosoma mansoni tyrosine kinase 0.0363 0.3132 0.535
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0126 0.0584 0.2407
Schistosoma mansoni growth factor receptor-bound protein 0.0107 0.0372 0.0581
Echinococcus multilocularis tyrosine protein kinase shark 0.0363 0.3132 0.3508
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0076 0.0038 0.001
Trypanosoma brucei protein kinase, putative 0.011 0.0414 0.1358
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0084 0.0124 0.0089
Echinococcus multilocularis activin receptor type 0.011 0.0414 0.0463
Trichomonas vaginalis TKL family protein kinase 0.0077 0.0048 0.0047
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0126 0.0584 0.2407
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0419 0.3734 0.3712
Trypanosoma cruzi casein kinase II, putative 0.0106 0.037 0.147
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0356 0.3063 0.343
Loa Loa (eye worm) camk/dcamkl protein kinase 0.016 0.095 0.0919
Schistosoma mansoni ste20-related kinase 0.0218 0.1572 0.2654
Echinococcus multilocularis dual specificity 0.0148 0.0815 0.0913
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0176 0.1119 0.4751
Echinococcus granulosus tyrosine protein kinase Lyn 0.0308 0.2545 0.4369
Echinococcus multilocularis cyclin dependent kinase 1 0.0126 0.0584 0.0654
Plasmodium falciparum serine/threonine protein kinase 0.0088 0.0176 0.1435
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0248 0.0602
Onchocerca volvulus 0.0136 0.069 0.2033
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0122 0.0542 0.093
Leishmania major protein kinase, putative 0.011 0.0414 0.166
Loa Loa (eye worm) hypothetical protein 0.0383 0.3349 0.3326
Brugia malayi Protein kinase domain containing protein 0.0364 0.3144 0.312
Plasmodium vivax glycogen synthase kinase 3, putative 0.0137 0.0697 0.6743
Toxoplasma gondii AGC kinase 0.0325 0.2721 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0075 0.0035 0.0039
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0419 0.3734 0.4182
Brugia malayi Protein kinase domain containing protein 0.013 0.0623 0.0591
Onchocerca volvulus 0.0136 0.069 0.2033
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0183 0.0531
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.012 0.0518 0.1733
Brugia malayi Temporarily assigned gene name protein 59 0.0137 0.0699 0.0667
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0075 0.0035 0.006
Echinococcus granulosus tyrosine protein kinase Src42A 0.0156 0.0908 0.1558
Giardia lamblia Kinase, CAMK CAMKL 0.0095 0.0248 0.0933
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0079 0.007 0.0126
Echinococcus granulosus tyrosine protein kinase Fyn 0.0273 0.2166 0.3719
Plasmodium falciparum calcium-dependent protein kinase 5 0.0107 0.0379 0.3501
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0248 0.0368
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0088 0.0172 0.0493
Trichomonas vaginalis CMGC family protein kinase 0.0095 0.0252 0.0778
Loa Loa (eye worm) AGC/PKG protein kinase 0.0143 0.0765 0.0732
Loa Loa (eye worm) casein kinase 0.0191 0.1286 0.1255
Echinococcus granulosus tyrosine protein kinase csk 0.0075 0.0035 0.006
Echinococcus multilocularis cyclin dependent kinase 5 0.0126 0.0584 0.0654
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0287 0.2317 0.3977
Leishmania major casein kinase II, putative 0.0106 0.037 0.147
Schistosoma mansoni nck2/grb4 0.0104 0.0349 0.0542
Echinococcus granulosus tyrosine protein kinase Src42A 0.0273 0.2166 0.3719
Echinococcus multilocularis serine:threonine protein kinase N2 0.0193 0.1307 0.1463
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0697 0.1872
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.012 0.0518 0.1733
Giardia lamblia Kinase, AGC PKA 0.012 0.0518 0.2117
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0119 0.0502 0.2046
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0145 0.0782 0.2783
Entamoeba histolytica protein kinase domain containing protein 0.013 0.0623 0.1664
Trypanosoma brucei cdc2-related kinase 3 0.0126 0.0584 0.197
Plasmodium vivax serine/threonine protein kinase, putative 0.0088 0.0176 0.1435
Loa Loa (eye worm) AUR protein kinase 0.0155 0.0889 0.0857
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Echinococcus granulosus protein kinase shaggy 0.0137 0.0697 0.1197
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0246 0.188 0.1852
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0283 0.2269 0.2541
Echinococcus granulosus cyclin dependent kinase 5 0.0126 0.0584 0.1003
Loa Loa (eye worm) hypothetical protein 0.0147 0.0811 0.0779
Echinococcus granulosus tyrosine kinase 0.0136 0.069 0.1185
Giardia lamblia Kinase, NEK 0.0145 0.0782 0.3276
Brugia malayi Casein kinase II, alpha chain 0.0106 0.037 0.0337
Giardia lamblia Kinase, CMGC CLK 0.0163 0.0983 0.4153
Schistosoma mansoni tyrosine kinase 0.0083 0.0119 0.0146
Onchocerca volvulus 0.0079 0.0072 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus granulosus casein kinase ii subunit alpha 0.0106 0.037 0.0636
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0325 0.2721 0.2696
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0187 0.1236 0.1205
Echinococcus granulosus tyrosine protein kinase csk 0.0075 0.0035 0.006
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0115 0.0468 0.1898
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.037 0.0949
Brugia malayi Protein kinase domain containing protein 0.0136 0.069 0.0658
Schistosoma mansoni serine/threonine protein kinase 0.025 0.1913 0.3244
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0075 0.0035 0.0039
Schistosoma mansoni protein kinase 0.0281 0.2255 0.3835
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0157 0.0438
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0463 0.4212 0.723
Echinococcus granulosus integrin linked protein kinase 0.0075 0.0035 0.006
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0389 0.342 0.5872
Echinococcus multilocularis transfer RNA-Thr 0.0075 0.0035 0.0039
Echinococcus granulosus receptor type guanylyl cyclase 0.0075 0.0035 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0542 0.1817
Brugia malayi serine/threonine protein kinase 6 0.0155 0.0889 0.0857
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0768 0.1265
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2253 0.3831
Brugia malayi Doublecortin family protein 0.016 0.095 0.0919
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0197 0.135 0.132
Entamoeba histolytica casein kinase, putative 0.0106 0.037 0.0949
Trypanosoma brucei aurora B kinase 0.0155 0.0889 0.3064
Trypanosoma cruzi casein kinase, putative 0.0115 0.0468 0.1898
Brugia malayi Protein kinase domain containing protein 0.0637 0.6089 0.6075
Schistosoma mansoni rap gtpase-activating protein 0.0119 0.0502 0.0806
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0075 0.0035 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Echinococcus multilocularis mitogen activated protein kinase 11 0.0169 0.1045 0.1171
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.013 0.0623 0.2579
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0106 0.037 0.3416
Loa Loa (eye worm) hypothetical protein 0.0091 0.0205 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0155 0.0889 0.3064
Echinococcus granulosus expressed protein 0.0088 0.0176 0.0302
Echinococcus multilocularis tyrosine protein kinase csk 0.0075 0.0035 0.0039
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.0176 0.0617
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.058
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0174 0.1102 0.1234
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0095 0.0248 0.0933
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0075 0.0035 0.0039
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0468 0.1553
Trypanosoma cruzi casein kinase, putative 0.0115 0.0468 0.1898
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0174 0.1102 0.1071
Loa Loa (eye worm) CDC7 protein kinase 0.0095 0.0252 0.0218
Brugia malayi cell division control protein 2 homolog 0.0126 0.0584 0.0551
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0193 0.1307 0.1463
Entamoeba histolytica protein kinase domain containing protein 0.0137 0.0697 0.1872
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.2317 0.3941
Trichomonas vaginalis AGC family protein kinase 0.0237 0.1774 0.6238
Echinococcus multilocularis myosin iiia 0.009 0.0194 0.0217
Entamoeba histolytica hypothetical protein 0.0076 0.0038 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Brugia malayi Kinase associated domain 1 family protein 0.0108 0.0389 0.0355
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0183 0.0531
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0154 0.0882 0.0988
Trichomonas vaginalis AGC family protein kinase 0.0237 0.1774 0.6238
Trypanosoma brucei polo-like protein kinase 0.0287 0.2317 0.8183
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0075 0.0035 0.0039
Loa Loa (eye worm) AUR protein kinase 0.0155 0.0889 0.0857
Brugia malayi SH2 domain containing protein 0.0458 0.4161 0.414
Echinococcus granulosus mitogen activated protein kinase 0.0089 0.0183 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0176 0.0243
Brugia malayi casein kinase I 0.0115 0.0468 0.0435
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0087 0.0157 0.0176
Giardia lamblia Kinase, NEK 0.0145 0.0782 0.3276
Entamoeba histolytica hypothetical protein 0.0076 0.0038 0.001
Schistosoma mansoni protein kinase 0.011 0.0414 0.0654
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.009 0.0194 0.0449
Echinococcus granulosus insulin growth factor 1 receptor beta 0.038 0.3324 0.5706
Echinococcus multilocularis rac serine:threonine kinase 0.0176 0.1119 0.1253
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Echinococcus granulosus tyrosine protein kinase csk 0.0075 0.0035 0.006
Schistosoma mansoni protein kinase 0.011 0.0414 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0246 0.1877 0.6605
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.023 0.1707 0.1678
Onchocerca volvulus 0.031 0.2566 0.7851
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Echinococcus multilocularis protein kinase 0.0075 0.0035 0.0039
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0155 0.0889 0.2416
Echinococcus granulosus dual specificity protein kinase clk2 0.0163 0.0983 0.1687
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0075 0.0036 0.004
Toxoplasma gondii aurora kinase 0.0155 0.0889 0.3181
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0148 0.0815 0.0783
Loa Loa (eye worm) hypothetical protein 0.0637 0.6089 0.6075
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0126 0.0584 0.0551
Trypanosoma brucei cdc2-related kinase 1 0.0126 0.0584 0.197
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.011 0.0414 0.166
Loa Loa (eye worm) hypothetical protein 0.0108 0.0389 0.0355
Onchocerca volvulus 0.0095 0.0252 0.0673
Brugia malayi Tyrosine-protein kinase abl-1 0.0264 0.2067 0.204
Schistosoma mansoni tyrosine kinase 0.0316 0.2632 0.4486
Schistosoma mansoni vav2 0.0115 0.0459 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.3734 0.6389
Echinococcus granulosus NDR protein kinase 0.0193 0.1307 0.2243
Echinococcus multilocularis calcium activated potassium channel 0.0143 0.0768 0.086
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0525 0.488 0.5465
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0089 0.0183 0.0649
Brugia malayi hypothetical protein 0.0236 0.1767 0.1738
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0468 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0119 0.0502 0.1674
Entamoeba histolytica protein kinase, putative 0.0088 0.0176 0.0398
Trypanosoma brucei rac serine-threonine kinase, putative 0.0334 0.2823 1
Brugia malayi Protein kinase domain containing protein 0.0096 0.0259 0.0225
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0273 0.2166 0.3719
Giardia lamblia Kinase, NEK 0.0145 0.0782 0.3276
Echinococcus granulosus tyrosine protein kinase HCK 0.0169 0.1041 0.1787
Echinococcus multilocularis casein kinase ii subunit alpha 0.0106 0.037 0.0415
Echinococcus multilocularis tyrosine protein kinase Abl 0.0264 0.2067 0.2315
Schistosoma mansoni serine/threonine protein kinase 0.0374 0.3258 0.5567
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0468 0.1553
Brugia malayi Protein kinase domain containing protein 0.0334 0.2823 0.2798
Trypanosoma brucei casein kinase I, isoform 2 0.0115 0.0468 0.1553
Loa Loa (eye worm) TK protein kinase 0.0169 0.1041 0.101
Onchocerca volvulus 0.0095 0.0252 0.0673
Echinococcus multilocularis mitogen activated protein kinase 11 0.0169 0.1045 0.1171
Echinococcus granulosus protein kinase c iota type 0.0326 0.2733 0.4692
Loa Loa (eye worm) hypothetical protein 0.0086 0.0155 0.0121
Schistosoma mansoni protein kinase 0.0091 0.0209 0.0301
Echinococcus multilocularis serine:threonine protein kinase 38 0.0193 0.1307 0.1463
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Brugia malayi Protein kinase domain containing protein 0.0326 0.2741 0.2716
Plasmodium falciparum cGMP-dependent protein kinase 0.0143 0.0765 0.7433
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0236 0.1767 0.1979
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0273 0.2166 0.2426
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Schistosoma mansoni ephrin receptor 0.0092 0.0214 0.0309
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Schistosoma mansoni tyrosine kinase 0.018 0.116 0.1943
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.4681 0.8024
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0193 0.1307 0.2243
Schistosoma mansoni serine/threonine protein kinase 0.0163 0.0983 0.1637
Plasmodium vivax tyrosine kinase-like protein, putative 0.0086 0.0152 0.1191
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0126 0.0584 0.0551
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0105 0.0357 0.0556
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0075 0.0035 0.0039
Schistosoma mansoni hypothetical protein 0.0108 0.0389 0.0611
Echinococcus multilocularis casein kinase i 0.0115 0.0468 0.0524
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0213 0.1521 0.1704
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0136 0.069 0.1853
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Loa Loa (eye worm) hypothetical protein 0.0128 0.0604 0.0571
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0107 0.0379 0.0345
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0088 0.0172 0.0493
Echinococcus multilocularis serine:threonine protein kinase 0.0121 0.0531 0.0594
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0169 0.1045 0.3624
Echinococcus multilocularis 0.0166 0.1013 0.1135
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Trichomonas vaginalis AGC family protein kinase 0.012 0.0518 0.1733
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0166 0.1017 0.1139
Echinococcus granulosus tyrosine protein kinase Fyn 0.0273 0.2166 0.3719
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.025 0.1913 0.3285
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0273 0.2166 0.2426
Brugia malayi ephrin receptor 1 precursor 0.0107 0.038 0.0346
Entamoeba histolytica PH domain containing protein kinase, putative 0.0176 0.1119 0.3066
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Schistosoma mansoni tyrosine kinase 0.0316 0.2632 0.4486
Loa Loa (eye worm) hypothetical protein 0.0119 0.0502 0.0468
Echinococcus granulosus raf serine:threonine protein kinase 0.012 0.0513 0.0881
Onchocerca volvulus Serine\/threonine kinase homolog 0.0287 0.2317 0.7079
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0374 0.3258 0.3235
Giardia lamblia Aurora kinase 0.0155 0.0889 0.3744
Toxoplasma gondii histone kinase SNF1, putative 0.0095 0.0248 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.0287 0.2317 0.8183
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0637 0.6089 0.6075
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0229 0.1696 0.1899
Plasmodium falciparum casein kinase 2, alpha subunit 0.0106 0.037 0.3416
Brugia malayi Stress-activated protein kinase jnk-1 0.0281 0.2248 0.2221
Giardia lamblia Kinase, AGC PKA 0.0166 0.1017 0.4303
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0155 0.0889 0.0996
Loa Loa (eye worm) hypothetical protein 0.0119 0.0502 0.0468
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.0889
Brugia malayi protein kinase C3,putative 0.0168 0.1029 0.0997
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0637 0.6089 0.6075
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0889 0.1476
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.1664 0.2814
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0205 0.1431 0.1401
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.0889
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.001
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0075 0.0035 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0252 0.0375
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0107 0.0379 0.1233
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0215 0.1543 0.2649
Loa Loa (eye worm) hypothetical protein 0.0152 0.0857 0.0825
Entamoeba histolytica protein kinase, putative 0.0155 0.0889 0.2416
Echinococcus multilocularis expressed conserved protein 0.0143 0.0765 0.0856
Schistosoma mansoni protein kinase 0.0389 0.342 0.5847
Onchocerca volvulus Tyrosine kinase homolog 0.0083 0.0119 0.0261
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0183 0.0649
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.011 0.0414 0.141
Loa Loa (eye worm) AGC/PKN protein kinase 0.0331 0.279 0.2764
Echinococcus multilocularis raf serine:threonine protein kinase 0.012 0.0513 0.0575
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0107 0.0379 0.065
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0419 0.3734 0.6411
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.025 0.1913 0.2143
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0248 0.0368
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0079 0.007 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0584 0.0949
Brugia malayi Protein kinase domain containing protein 0.023 0.1707 0.1678
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0134 0.0667 0.2768
Echinococcus multilocularis FL cytokine receptor 0.0075 0.0035 0.0039
Giardia lamblia Kinase, CMGC GSK 0.0137 0.0697 0.2902
Schistosoma mansoni tyrosine kinase 0.0295 0.2407 0.4097
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.012 0.0518 0.2117
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0768 0.1265
Echinococcus granulosus Glutaredoxin protein 5 0.0131 0.0638 0.1095
Schistosoma mansoni protein kinase 0.0155 0.0889 0.1476
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0075 0.0035 0.0061
Entamoeba histolytica hypothetical protein 0.0076 0.0038 0.001
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0468 0.1553
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1696 0.2869
Echinococcus granulosus casein kinase I delta 0.0115 0.0468 0.0804
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.1307 0.2196
Brugia malayi Fes/CIP4 homology domain containing protein 0.0124 0.0562 0.0529
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Leishmania major protein kinase, putative 0.009 0.0194 0.0695
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0163 0.0983 0.4153
Brugia malayi SH2 domain containing protein 0.0136 0.069 0.0658
Schistosoma mansoni protein kinase 0.0115 0.0468 0.0748
Brugia malayi probable protein kinase 0.0281 0.2255 0.2228
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0183 0.0256
Loa Loa (eye worm) hypothetical protein 0.0221 0.1605 0.1575
Echinococcus granulosus cyclin dependent kinase 1 0.0126 0.0584 0.1003
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0273 0.2166 0.2426
Loa Loa (eye worm) hypothetical protein 0.0147 0.0811 0.0779
Giardia lamblia Kinase, CK1 Casein kinase 0.0115 0.0468 0.1898
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.0518 0.0485
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0075 0.0035 0.004
Echinococcus multilocularis death associated protein kinase 1 0.0901 0.893 1
Schistosoma mansoni serine/threonine-protein kinase 0.0176 0.1119 0.1872
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.0671 0.228
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0087 0.0157 0.0438
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0095 0.0248 0.0278
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0163 0.0983 0.4153
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.0689 0.0656
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0077 0.0058 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0287 0.2317 1
Echinococcus granulosus casein kinase I delta 0.0115 0.0468 0.0804
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0542 0.1817
Echinococcus multilocularis casein kinase I delta 0.0115 0.0468 0.0524
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0525 0.488 0.8378
Plasmodium falciparum glycogen synthase kinase 3 0.0137 0.0697 0.6743
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0169 0.1045 0.1014
Plasmodium falciparum calcium-dependent protein kinase 1 0.0107 0.0379 0.3501
Echinococcus granulosus tyrosine kinase 0.0229 0.1696 0.2912
Echinococcus multilocularis tyrosine protein kinase HCK 0.0169 0.1041 0.1166
Loa Loa (eye worm) SRC-1 0.0273 0.2166 0.2139
Entamoeba histolytica protein kinase, putative 0.013 0.0623 0.1664
Echinococcus granulosus mitogen activated protein kinase 3 0.0089 0.0183 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.2142 0.3639
Toxoplasma gondii CMGC kinase, CK2 family 0.0106 0.037 0.1249
Loa Loa (eye worm) AUR protein kinase 0.0155 0.0889 0.0857
Plasmodium vivax calcium-dependent protein kinase, putative 0.0107 0.0379 0.3501
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.013 0.0623 0.0591
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0155 0.0889 0.2416
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0287 0.2317 0.229
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0075 0.0035 0.0039
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0156 0.0908 0.1017
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0126 0.0584 0.2045
Echinococcus granulosus serine:threonine protein kinase 0.0121 0.0531 0.0911
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0374 0.3258 1
Onchocerca volvulus 0.0115 0.0468 0.1344
Echinococcus multilocularis cyclin dependent kinase 1 0.0126 0.0584 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.1307 0.2196
Trichomonas vaginalis AGC family protein kinase 0.0088 0.0172 0.0493
Schistosoma mansoni tyrosine kinase 0.0612 0.5825 0.9999
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.058
Schistosoma mansoni protein kinase 0.0091 0.0209 0.0301
Loa Loa (eye worm) hypothetical protein 0.0107 0.0379 0.0345
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0083 0.0119 0.0205
Brugia malayi Protein kinase domain containing protein 0.0476 0.4356 0.4336
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0166 0.1017 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0231 0.1714 0.1685
Giardia lamblia Kinase, CMGC SRPK 0.0088 0.0176 0.0617
Echinococcus granulosus protein kinase 0.0163 0.0977 0.1677
Echinococcus multilocularis dual specificity 0.0148 0.0815 0.0913
Plasmodium falciparum protein serine/threonine kinase-1 0.0163 0.0983 0.9652
Plasmodium falciparum NIMA related kinase 1 0.0145 0.0782 0.7614
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0119 0.0502 0.0806
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0126 0.0584 0.0551
Brugia malayi Protein kinase domain containing protein 0.0163 0.0983 0.0951
Leishmania major protein kinase A catalytic subunit isoform 2 0.012 0.0518 0.2117
Loa Loa (eye worm) TK/FER protein kinase 0.0458 0.4161 0.414
Entamoeba histolytica protein kinase, putative 0.0096 0.0257 0.0629
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.0518 0.0485
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0107 0.0379 0.065
Schistosoma mansoni protein kinase 0.0106 0.037 0.0579
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0468 0.0524
Echinococcus multilocularis growth factor receptor bound protein 2 0.0104 0.0349 0.0391
Echinococcus granulosus protein kinase C gamma type 0.0237 0.1775 0.3046
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0107 0.0379 0.3501
Entamoeba histolytica protein kinase, putative 0.0148 0.0815 0.2206
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0213 0.1521 0.2611
Loa Loa (eye worm) hypothetical protein 0.0119 0.0502 0.0468
Trichomonas vaginalis STE family protein kinase 0.009 0.0194 0.0569
Entamoeba histolytica protein kinase, putative 0.0109 0.0393 0.1013
Echinococcus multilocularis protein kinase c iota type 0.0326 0.2733 0.3061
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0095 0.0248 0.0933
Giardia lamblia Kinase, CMGC CDK 0.0126 0.0584 0.2407
Echinococcus granulosus activated cdc42 kinase 1 0.0075 0.0035 0.006
Brugia malayi Sex muscle abnormal protein 5 0.0104 0.0349 0.0315
Loa Loa (eye worm) AGC/NDR protein kinase 0.0193 0.1307 0.1276
Echinococcus granulosus epidermal growth factor receptor 0.0392 0.3444 0.5912
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0148 0.0815 0.3418
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0036 0.0001
Schistosoma mansoni serine/threonine-protein kinase 0.0176 0.1119 0.1872
Brugia malayi Protein kinase domain containing protein 0.0206 0.1441 0.1411
Giardia lamblia Kinase, CMGC GSK 0.0137 0.0697 0.2902
Echinococcus granulosus serine:threonine protein kinase N2 0.0138 0.0707 0.1213
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0119 0.0502 0.0861
Echinococcus granulosus tyrosine protein kinase pr2 0.0075 0.0035 0.006
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0169 0.1045 0.4428
Loa Loa (eye worm) TK/FER protein kinase 0.0136 0.069 0.0658
Brugia malayi serine/threonine kinase 12 0.0155 0.0889 0.0857
Echinococcus granulosus serine:threonine protein kinase 0.0121 0.0531 0.0911
Leishmania major protein kinase A catalytic subunit 0.012 0.0518 0.2117
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.1543 0.2604
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0104 0.0349 0.0542
Trichomonas vaginalis AGC family protein kinase 0.0079 0.007 0.0126
Brugia malayi Protein kinase domain containing protein 0.0151 0.0856 0.0824
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0122 0.0542 0.0607
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0163 0.0977 0.0945
Schistosoma mansoni tyrosine kinase 0.018 0.116 0.1943
Brugia malayi Protein kinase domain containing protein 0.0121 0.0531 0.0497
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0197 0.135 0.2318
Echinococcus granulosus serine threonine protein kinase nrc 0.0166 0.1017 0.1746
Echinococcus multilocularis protein kinase 0.0075 0.0035 0.0039
Trypanosoma brucei Casein kinase II 0.0106 0.037 0.1203
Entamoeba histolytica protein kinase domain containing protein 0.011 0.0414 0.1071
Echinococcus granulosus dual specificity testis-specific protein kinase 0.011 0.0414 0.071
Plasmodium falciparum calcium-dependent protein kinase 4 0.0107 0.0379 0.3501
Echinococcus multilocularis integrin linked protein kinase 0.0075 0.0035 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0584 0.0949
Plasmodium falciparum casein kinase 1 0.0115 0.0468 0.4412
Toxoplasma gondii AGC kinase 0.012 0.0518 0.1799
Entamoeba histolytica protein kinase, putative 0.0169 0.1041 0.2845
Schistosoma mansoni tyrosine kinase 0.0273 0.2166 0.3681
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0083 0.0119 0.0133
Brugia malayi serine/threonine-protein kinase PAK 7 0.0246 0.188 0.1852
Brugia malayi putative serine/threonine kinase SADA gamma 0.0095 0.0248 0.0214
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0143 0.0765 0.2717
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0124 0.0564 0.0531
Trichomonas vaginalis AGC family protein kinase 0.0334 0.2823 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0463 0.4212 0.4717
Schistosoma mansoni tyrosine kinase 0.0392 0.3444 0.5887
Trichomonas vaginalis TK family protein kinase 0.0077 0.0048 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0248 0.0764
Plasmodium vivax casein kinase 1, putative 0.0115 0.0468 0.4412
Echinococcus multilocularis 0.0163 0.0977 0.1094
Schistosoma mansoni adapter molecule crk 0.0104 0.0349 0.0542
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0193 0.1307 0.1463
Trypanosoma cruzi cdc2-related kinase 3 0.0126 0.0584 0.2407
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.0518 0.058
Loa Loa (eye worm) TK/ALK protein kinase 0.0326 0.274 0.2715
Schistosoma mansoni tyrosine kinase 0.0109 0.0394 0.062
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0088 0.0176 0.0524
Echinococcus granulosus cGMP dependent protein kinase 0.0143 0.0765 0.1313
Entamoeba histolytica PH domain containing protein kinase, putative 0.0176 0.1119 0.3066
Echinococcus multilocularis dual specificity protein kinase clk2 0.0163 0.0983 0.11
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.037 0.1203
Onchocerca volvulus 0.0136 0.069 0.2033
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0193 0.1307 0.2243

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 100 uM Inhibition of human liver GPa in presence of glucose ChEMBL. 16942879
IC50 (binding) = 100 uM Inhibition of human liver GPa in presence of glucose ChEMBL. 16942879
Inhibition (functional) = -10.1 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -1.97 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = -0.68 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 12 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 99 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.68 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -6 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 2 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 12 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 99 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.12 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.75825 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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