Detailed information for compound 48918

Basic information

Technical information
  • TDR Targets ID: 48918
  • Name: 2-[4-(2-amino-2-oxoethyl)-3-oxo-1,4-benzothia zin-2-yl]-N-hydroxyacetamide
  • MW: 295.314 | Formula: C12H13N3O4S
  • H donors: 3 H acceptors: 4 LogP: -0.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CC1Sc2ccccc2N(C1=O)CC(=O)N
  • InChi: 1S/C12H13N3O4S/c13-10(16)6-15-7-3-1-2-4-8(7)20-9(12(15)18)5-11(17)14-19/h1-4,9,19H,5-6H2,(H2,13,16)(H,14,17)
  • InChiKey: AWDOSWMBHGGYOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-[2-(hydroxyamino)-2-oxo-ethyl]-3-oxo-1,4-benzothiazin-4-yl]acetamide
  • 2-[2-[2-(hydroxyamino)-2-oxoethyl]-3-oxo-1,4-benzothiazin-4-yl]acetamide
  • 2-[4-(2-azanyl-2-oxo-ethyl)-3-oxo-1,4-benzothiazin-2-yl]-N-hydroxy-ethanamide
  • 2-[2-[2-(hydroxyamino)-2-keto-ethyl]-3-keto-1,4-benzothiazin-4-yl]acetamide
  • 2-[4-(2-amino-2-oxo-ethyl)-3-oxo-1,4-benzothiazin-2-yl]-N-hydroxy-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus subsp. aureus Mu50 Peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi hypothetical protein Peptide deformylase   183 aa 155 aa 22.6 %
Trichomonas vaginalis abca6, putative Peptide deformylase   183 aa 162 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1395 0.405
Loa Loa (eye worm) beta-lactamase 0.0035 0.0318 0.0474
Brugia malayi calpain family protein 1 0.0108 0.1238 0.1847
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0073 0.0207
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0333 0.117
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0002 0.0002
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0111 0.0262
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1628 0.5737
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0012 0.0023 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0073 0.015
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0538 0.6704 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.001 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1395 0.2081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1395 0.3806
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0013 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0127 0.1484 0.2213
Echinococcus granulosus lamin 0.0027 0.0207 0.073
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0322 0.0938
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.13 0.194
Echinococcus granulosus caspase 2 0.0061 0.0642 0.2263
Onchocerca volvulus 0.0027 0.0207 0.0726
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0333 0.0904
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0401 0.1071
Plasmodium falciparum subtilisin-like protease 3 0.0017 0.0079 0.0225
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.051 0.1441
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Brugia malayi calpain 7 0.0041 0.0385 0.0574
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1679 0.1679
Echinococcus granulosus prolyl endopeptidase 0.0127 0.1484 0.5228
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0201 0.2427 0.8553
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0318 0.0842
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Mycobacterium ulcerans lipase LipD 0.0035 0.0318 0.0873
Leishmania major DNA polymerase eta, putative 0.0019 0.0111 0.0297
Toxoplasma gondii subtilisin SUB6 0.0017 0.0079 0.0225
Onchocerca volvulus 0.0029 0.0241 0.0845
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0035 0.0069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0318 0.0925
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0111 0.0319
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0925
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0318 0.0925
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2468 0.3682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0012 0.0023 0.0036
Echinococcus granulosus glycoprotein Antigen 5 0.0012 0.0022 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.04 0.1411
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0118
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0073 0.0249
Echinococcus granulosus bloom syndrome protein 0.0021 0.0134 0.0474
Schistosoma mansoni alpha glucosidase 0.0036 0.0322 0.048
Schistosoma mansoni survival motor neuron protein 0.0048 0.0474 0.0706
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1026
Toxoplasma gondii subtilisin SUB12 0.0017 0.0079 0.0225
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0013 0.0037 0.0056
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1366 0.4
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0459 0.1339
Toxoplasma gondii subtilisin SUB10 0.0017 0.0079 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0037 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Onchocerca volvulus 0.0012 0.0022 0.007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0333 0.117
Trypanosoma brucei glucosidase, putative 0.0036 0.0322 0.0854
Leishmania major calpain family cysteine protease-like protein 0.0012 0.0023 0.0058
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0318 0.0925
Brugia malayi Fli-1 protein 0.0218 0.2635 0.3931
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0111 0.0165
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0111 0.0165
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.122 0.3314
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1914 0.2855
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.159 0.2371
Loa Loa (eye worm) hypothetical protein 0.0027 0.0207 0.0309
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0002 0.0002
Echinococcus granulosus geminin 0.0167 0.1985 0.6995
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0318 0.0925
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1663 0.4527
Brugia malayi Trypsin family protein 0.0012 0.0022 0.0032
Echinococcus granulosus membrane bound transcription factor site 1 0.0017 0.0079 0.0278
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0779 0.0779
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0385 0.1026
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0241 0.0241
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0111 0.0111
Onchocerca volvulus 0.0012 0.0022 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Trypanosoma cruzi kinesin, putative 0.0028 0.0229 0.06
Echinococcus granulosus furin 0.0017 0.0079 0.0278
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2742 0.8035
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Entamoeba histolytica calpain large subunit domain III containing protein 0.0028 0.0229 0.6422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.159 0.2371
Echinococcus multilocularis calpain 0.0041 0.0385 0.0385
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0509 0.1366
Leishmania major kinesin, putative 0.0028 0.0229 0.0621
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1026
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0022 0.0022
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.051 0.137
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.051 0.137
Loa Loa (eye worm) glutathione reductase 0.0046 0.0459 0.0684
Loa Loa (eye worm) prolyl oligopeptidase 0.0013 0.0037 0.0056
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0186 0.2228 0.3324
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0013 0.0037 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3661 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0322 0.0854
Echinococcus multilocularis lamin dm0 0.0027 0.0207 0.0207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 0.3412 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0017 0.0079 0.0118
Toxoplasma gondii subtilisin SUB11 0.0017 0.0079 0.0225
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0037 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1395 0.405
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0322 0.1132
Brugia malayi Ets-domain containing protein 0.0072 0.0779 0.1163
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1046
Plasmodium falciparum glutathione reductase 0.0016 0.0073 0.0207
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1216 0.3559
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0002 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0111 0.0384
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.122 0.3329
Echinococcus granulosus Mastin 0.0012 0.0022 0.0077
Brugia malayi hypothetical protein 0.0033 0.0282 0.042
Plasmodium falciparum calpain 0.0012 0.0023 0.0062
Echinococcus granulosus calpain A 0.0041 0.0385 0.1356
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0013 0.0037 0.0056
Trypanosoma cruzi conserved protein 0.0012 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0474 0.0706
Treponema pallidum mcbG protein 0.0023 0.0157 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1026
Trichomonas vaginalis hypothetical protein 0.0012 0.0023 0.0075
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0017 0.0079 0.0169
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0055
Loa Loa (eye worm) hypothetical protein 0.0108 0.1238 0.1847
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0013 0.0037 0.0994
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0459 0.0684
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0509 0.1487
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0111 0.0319
Brugia malayi hypothetical protein 0.0061 0.0642 0.0958
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0113 0.13 0.4582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Echinococcus granulosus calpain A 0.0113 0.13 0.4582
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0002 0.0007
Trypanosoma brucei Peptide deformylase 2 0.0106 0.122 0.3314
Echinococcus multilocularis calpain A 0.0113 0.13 0.13
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Brugia malayi calpain D 0.0012 0.0023 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0318 0.0925
Onchocerca volvulus 0.0035 0.0318 0.1117
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0002 0.0007
Leishmania major DNA polymerase kappa, putative 0.0019 0.0111 0.0297
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0111 0.0275
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1395 0.4915
Echinococcus granulosus Furin 1 0.0017 0.0079 0.0278
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0013 0.0037 0.0124
Brugia malayi hypothetical protein 0.0234 0.2838 0.4233
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0318 0.0842
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0192
Loa Loa (eye worm) hypothetical protein 0.0079 0.0877 0.1308
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.0232
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0284 0.0827
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0013 0.0037 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Schistosoma mansoni lamin 0.0027 0.0207 0.0309
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0111 0.0275
Echinococcus multilocularis apoptotic protease activating factor 1 0.0061 0.0642 0.0642
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0385 0.1026
Echinococcus multilocularis 0.0017 0.0079 0.0079
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0207 0.0309
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0022
Trypanosoma brucei cysteine peptidase, putative 0.0012 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0312 0.3832 0.5716
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.051 0.137
Brugia malayi Subtilase family protein 0.0538 0.6704 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0113 0.13 0.194
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1026
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1914 0.1914
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.159 0.5602
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0073 0.0192
Loa Loa (eye worm) RecQ helicase 0.0021 0.0134 0.02
Loa Loa (eye worm) calpain D 0.0012 0.0023 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0035 0.0069
Brugia malayi prolyl oligopeptidase family protein 0.0013 0.0037 0.0056
Trypanosoma brucei unspecified product 0.0013 0.0035 0.0069
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0073 0.0171
Echinococcus granulosus inhibitor of apoptosis protein 0.0186 0.2228 0.7851
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0779 0.2746
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Loa Loa (eye worm) hypothetical protein 0.0061 0.0642 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Echinococcus multilocularis lamin 0.0027 0.0207 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0227 0.08
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0073 0.0108
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0318 0.0873
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0012 0.0023 0.0062
Trypanosoma cruzi oligopeptidase b 0.0051 0.051 0.137
Loa Loa (eye worm) hypothetical protein 0.0067 0.0721 0.1076
Toxoplasma gondii hypothetical protein 0.0012 0.0023 0.0062
Entamoeba histolytica recQ family helicase, putative 0.0011 0.001 0.023
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0022 0.0032
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0013 0.0037 0.0124
Brugia malayi glutathione reductase 0.0046 0.0459 0.0684
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.051 0.1389
Loa Loa (eye worm) hypothetical protein 0.0019 0.0111 0.0165
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0073 0.0256
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0333 0.0883
Schistosoma mansoni inhibitor of apoptosis protein 0.0186 0.2228 0.3324
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1366 0.4
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0333 0.0883
Loa Loa (eye worm) inositol-1 0.0037 0.0333 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0079 0.0272
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0518 0.139
Schistosoma mansoni multidrug resistance protein 0.0011 0.0002 0.0003
Mycobacterium ulcerans hypothetical protein 0.0035 0.0318 0.0873
Echinococcus multilocularis calpain 5 0.0041 0.0385 0.0385
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0134 0.0468
Trypanosoma brucei unspecified product 0.0019 0.0111 0.0275
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0012 0.0022 0.0077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0459 0.0459
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0038
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0322 0.0874
Chlamydia trachomatis peptide deformylase 0.0279 0.3412 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1216 0.341
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.051 0.1295
Brugia malayi Trypsin-like protease protein 5 0.0012 0.0022 0.0032
Schistosoma mansoni hypothetical protein 0.0061 0.0642 0.0958
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1216 0.3559
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0111 0.0165
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0127 0.1484 0.4049
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0157 0.0401
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Toxoplasma gondii subtilisin SUB8 0.0017 0.0079 0.0225
Trichomonas vaginalis esterase, putative 0.0035 0.0318 0.1117
Trypanosoma brucei Calpain-like protein 2 0.0012 0.0023 0.0036
Mycobacterium tuberculosis Conserved protein 0.0023 0.0157 0.0453
Toxoplasma gondii prolyl endopeptidase 0.0127 0.1484 0.4345
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.159 0.159
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0318 0.1117
Brugia malayi hypothetical protein 0.0012 0.0022 0.0032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0037 0.0984
Echinococcus multilocularis inhibitor of apoptosis protein 0.0186 0.2228 0.2228
Schistosoma mansoni inositol monophosphatase 0.0037 0.0333 0.0496
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Toxoplasma gondii ABC1 family protein 0.0035 0.0318 0.0925
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1371 0.2045
Echinococcus multilocularis geminin 0.0167 0.1985 0.1985
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0111 0.039
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0318 0.0925
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0073 0.0171
Onchocerca volvulus 0.0093 0.1051 0.3713
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Echinococcus granulosus intermediate filament protein 0.0027 0.0207 0.073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0073 0.1106
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0073 0.0207
Plasmodium vivax subtilisin-like serine protease, putative 0.0017 0.0079 0.0225
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0017 0.0079 0.0225
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0017 0.0079 0.0278
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0037 0.0123
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0111 0.0165
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0385 0.1026
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1663 0.4539
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Schistosoma mansoni calpain-2 (C02 family) 0.0012 0.0023 0.0035
Echinococcus multilocularis dna polymerase eta 0.0019 0.0111 0.0111
Plasmodium falciparum thioredoxin reductase 0.0046 0.0459 0.1339
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Schistosoma mansoni alpha-glucosidase 0.0139 0.1629 0.243
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2838 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0333 0.117
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0322 0.0322
Loa Loa (eye worm) calpain family protein 1 0.0079 0.0877 0.1308
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0013 0.0037 0.0994
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Plasmodium vivax subtilisin-like protease 2, putative 0.0017 0.0079 0.0225
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0001 0.0001
Brugia malayi Trypsin family protein 0.0012 0.0022 0.0032
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1366 0.4
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0022 0.0022
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0012 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0186 0.2228 0.3324
Brugia malayi Inositol-1 0.0037 0.0333 0.0496
Echinococcus multilocularis Furin 1 0.0017 0.0079 0.0079
Brugia malayi Cell death protein 3 precursor 0.0061 0.0642 0.0958
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0322 0.9036
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0017 0.0079 0.0118
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0779 0.1163
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0111 0.0384
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1216 0.3559
Brugia malayi prolyl oligopeptidase family protein 0.0013 0.0037 0.0056
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0318 0.0474
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0318 0.0474
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Echinococcus multilocularis calpain 7 (C02 family) 0.0041 0.0385 0.0385
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0385 0.0574
Mycobacterium ulcerans beta-lactamase 0.0035 0.0318 0.0873
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0013 0.0037 0.0074
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1395 0.4084
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Schistosoma mansoni gabp alpha 0.0072 0.0779 0.1163
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0134 0.0468
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0111 0.0275
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0642 0.0958
Trypanosoma brucei hypothetical protein 0.0012 0.0023 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0023 0.0075
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0017 0.0079 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0037 0.0103
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0012 0.0022 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.1117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0322 0.1132
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0073 0.0249
Trypanosoma brucei prolyl endopeptidase 0.0127 0.1484 0.4036
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0509 0.0759
Brugia malayi Thioredoxin reductase 0.0046 0.0459 0.0684
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1366 0.3861
Trichomonas vaginalis calpain, putative 0.0012 0.0023 0.0075
Mycobacterium tuberculosis Probable reductase 0.0106 0.1216 0.3559
Brugia malayi hypothetical protein 0.012 0.1389 0.2072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1395 0.2081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0017 0.0079 0.0188
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0322 0.1132
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.001 0.0022
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0318 0.0716
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0118
Echinococcus multilocularis hypothetical protein 0.0041 0.0385 0.0385
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0111 0.0262
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0333 0.097
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 0.3412 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1216 0.3559
Toxoplasma gondii thioredoxin reductase 0.0046 0.0459 0.1339
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0013 0.0037 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Echinococcus granulosus transmembrane protease serine 3 0.0012 0.0022 0.0077
Trypanosoma brucei oligopeptidase b 0.0051 0.051 0.137
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0113 0.13 0.13
Schistosoma mansoni inositol monophosphatase 0.0037 0.0333 0.0496
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0111 0.0111
Schistosoma mansoni site-1 peptidase (S08 family) 0.0017 0.0079 0.0118
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.3661 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0037 0.0123
Leishmania major calpain protease-like protein 0.0012 0.0023 0.0058
Echinococcus granulosus lamin dm0 0.0027 0.0207 0.073
Schistosoma mansoni site-1 peptidase (S08 family) 0.0017 0.0079 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Plasmodium falciparum subtilisin-like protease 2 0.0017 0.0079 0.0225
Onchocerca volvulus 0.0035 0.0318 0.1117
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Onchocerca volvulus 0.0067 0.0721 0.2546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0241 0.0359
Leishmania major hypothetical protein, unknown function 0.0012 0.0023 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0241 0.0848
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0134 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.159 0.2371
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.005 0.0074
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0073 0.0108
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0017 0.0079 0.0225
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.1117
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0017 0.0079 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Loa Loa (eye worm) prolyl oligopeptidase 0.0013 0.0037 0.0056
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.051 0.137
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0073 0.015
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0322 0.1132
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0322 0.048
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0037 0.0073
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0073 0.0171
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.3661 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0647 0.0965
Loa Loa (eye worm) hypothetical protein 0.0186 0.2228 0.3324
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0241 0.0359
Schistosoma mansoni smdr2 0.0011 0.0002 0.0003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.1484 0.2213
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0073 0.0207
Onchocerca volvulus 0.0233 0.2828 1
Toxoplasma gondii hypothetical protein 0.0279 0.3412 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Brugia malayi Pre-SET motif family protein 0.0029 0.0241 0.0359
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0017 0.0079 0.0169
Toxoplasma gondii subtilisin SUB9 0.0017 0.0079 0.0225
Echinococcus multilocularis Mastin 0.0012 0.0022 0.0022
Brugia malayi beta-lactamase family protein 0.0035 0.0318 0.0474
Toxoplasma gondii subtilisin SUB4 0.0017 0.0079 0.0225
Trypanosoma brucei calpain, putative 0.0012 0.0023 0.0036
Onchocerca volvulus Deterin homolog 0.0186 0.2228 0.7878
Loa Loa (eye worm) proprotein convertase 2 0.0017 0.0079 0.0118
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0037 0.0123
Echinococcus multilocularis membrane bound transcription factor site 1 0.0017 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 0.3412 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0073 0.0207
Trichomonas vaginalis calpain, putative 0.0012 0.0023 0.0075
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0002 0.0002
Loa Loa (eye worm) endoprotease bli-4 0.0017 0.0079 0.0118
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0056
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2838 0.2838
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0155 0.0155
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0037 0.0095
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.1314 0.3848
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0017 0.0079 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0509 0.1366
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0032
Trypanosoma brucei calpain, putative 0.0012 0.0023 0.0036
Brugia malayi beta-lactamase family protein 0.0035 0.0318 0.0474
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1663 0.4527
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1914 0.1914
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0017 0.0079 0.0118
Trypanosoma brucei Calpain-like protein CALP1.3 0.0012 0.0023 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0241 0.0359
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.0124
Onchocerca volvulus 0.0027 0.0207 0.0726
Trypanosoma cruzi oligopeptidase b 0.0051 0.051 0.137
Trypanosoma cruzi prolyl endopeptidase 0.0127 0.1484 0.4036
Loa Loa (eye worm) fli-1 protein 0.0218 0.2635 0.3931
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0322 0.1132
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0032
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0037 0.0055
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0201 0.2427 0.2427
Schistosoma mansoni hypothetical protein 0.0167 0.1985 0.2961
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0207 0.0309
Brugia malayi celfurPC protein 0.0017 0.0079 0.0118
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0155 0.0548
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1395 0.1395
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0356 0.1038
Trypanosoma brucei unspecified product 0.0013 0.0035 0.0069
Trypanosoma brucei subtilisin peptidase 0.0017 0.0079 0.0188
Toxoplasma gondii subtilisin SUB2 0.0017 0.0079 0.0225
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0284 0.0615
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Trichomonas vaginalis calpain, putative 0.0012 0.0023 0.0075
Plasmodium vivax glutathione reductase, putative 0.0046 0.0459 0.1339
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0017 0.0079 0.0188
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.122 0.3314
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0002 0.0002
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.051 0.1491
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.04 0.1168
Brugia malayi prolyl oligopeptidase family protein 0.0013 0.0037 0.0056
Giardia lamblia DINP protein human, muc B family 0.0019 0.0111 0.2304
Entamoeba histolytica calpain family cysteine protease, putative 0.0012 0.0023 0.0597
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0046 0.0129
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3661 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0032 0.0111
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.04 0.1168
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0333 0.9342
Plasmodium falciparum glutathione reductase 0.0046 0.0459 0.1339
Trypanosoma brucei Calpain-like protein 1.1 0.0012 0.0023 0.0036
Trypanosoma brucei antigen, putative 0.0041 0.0385 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0079 0.0272
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0018 0.0027
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0385 0.1026
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0157 0.0401
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0401 0.1071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0012 0.0023 0.0036
Onchocerca volvulus Prolyl endopeptidase homolog 0.0127 0.1484 0.5244
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0322 0.048
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0318 0.1119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0074
Leishmania major hypothetical protein, conserved 0.005 0.0509 0.1385
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1679 0.2504
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Echinococcus granulosus calpain 5 0.0041 0.0385 0.1356
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0925
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0056
Mycobacterium ulcerans hypothetical protein 0.0157 0.1866 0.544
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Plasmodium vivax peptide deformylase, putative 0.0279 0.3412 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.159 0.5602
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0002 0.0007
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0.0037 0.0994
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0509 0.1487
Loa Loa (eye worm) hypothetical protein 0.0234 0.2838 0.4233
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0037 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0322 0.0854
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.159 0.2371
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0186 0.2228 0.7851
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0074
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0037 0.0123
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0157 0.0453
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0018 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0073 0.0171
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0073 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.122 0.3314
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0.0037 0.0994
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0073 0.0207
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0078 0.0117
Plasmodium falciparum subtilisin-like protease 1 0.0017 0.0079 0.0225
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0108 0.1238 0.1847
Trypanosoma cruzi kinesin, putative 0.0028 0.0229 0.06
Mycobacterium tuberculosis Conserved protein 0.0035 0.0318 0.0925
Schistosoma mansoni DNA polymerase eta 0.0019 0.0111 0.0165
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0002 0.0002
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0013 0.0037 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1395 0.405
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0318 0.0318
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0017 0.0079 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.04 0.1168
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0017 0.0079 0.0225
Plasmodium falciparum peptide deformylase 0.0279 0.3412 1
Leishmania major hypothetical protein, conserved 0.0023 0.0157 0.0422
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0035 0.0069
Schistosoma mansoni calpain C (C02 family) 0.0041 0.0385 0.0574
Brugia malayi calpain 5 0.0028 0.0229 0.0342
Trypanosoma cruzi subtilisin peptidase 0.0017 0.0079 0.0188
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0318 0.0474
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1395 0.4084
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0013 0.0037 0.0096
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Toxoplasma gondii subtilisin SUB7 0.0017 0.0079 0.0225
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.04 0.141
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Brugia malayi ABC transporter family protein 0.0011 0.0002 0.0003
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Mycobacterium ulcerans peptide deformylase 0.0279 0.3412 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0401 0.1071
Onchocerca volvulus 0.0012 0.0022 0.007
Brugia malayi Pre-SET motif family protein 0.0205 0.2468 0.3682
Mycobacterium leprae Probable lipase LipE 0.0035 0.0318 0.0716
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0322 0.1132
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2828 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.159 0.159
Brugia malayi Trypsin family protein 0.0012 0.0022 0.0032
Brugia malayi calpain 5 0.0012 0.0023 0.0035
Brugia malayi Ets-domain containing protein 0.0072 0.0779 0.1163
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0041 0.0385 0.1026
Echinococcus granulosus Dipeptidyl peptidase 9 0.0013 0.0037 0.0131
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0318 0.0925
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0333 0.0917
Leishmania major subtilisin-like serine peptidase 0.0017 0.0079 0.021
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.04 0.141
Schistosoma mansoni alpha-glucosidase 0.0139 0.1629 0.243
Toxoplasma gondii hypothetical protein 0.0013 0.0037 0.0103
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0073 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.159 0.2371
Echinococcus multilocularis acylamino acid releasing enzyme 0.0013 0.0037 0.0037
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0333 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0079 0.0272
Plasmodium vivax SET domain protein, putative 0.0029 0.0241 0.07
Entamoeba histolytica protein kinase, putative 0.0028 0.0229 0.6422
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0.0037 0.0994
Brugia malayi intermediate filament protein 0.0027 0.0207 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0079 0.0272
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0385 0.0574
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0012 0.0022 0.0032
Onchocerca volvulus 0.0186 0.2228 0.7878
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Onchocerca volvulus 0.0048 0.0474 0.1669
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0318 0.0873
Leishmania major oligopeptidase b 0.0051 0.051 0.1389
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0459 0.1616
Entamoeba histolytica hypothetical protein, conserved 0.0013 0.0037 0.0994
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0013 0.0037 0.0074
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0509 0.1487
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0002 0.0002
Brugia malayi MH2 domain containing protein 0.0118 0.1371 0.2045
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0322 0.1132
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0017 0.0079 0.0188
Brugia malayi Trypsin family protein 0.0012 0.0022 0.0032
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0073 0.0207
Schistosoma mansoni multidrug resistance protein 0.0011 0.0002 0.0003
Onchocerca volvulus 0.0012 0.0022 0.007
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0001 0.0002
Loa Loa (eye worm) calpain 0.0041 0.0385 0.0574
Plasmodium vivax subtilisin-like protease 1 0.0017 0.0079 0.0225
Brugia malayi hypothetical protein 0.005 0.0509 0.0759
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0017 0.0079 0.0118
Loa Loa (eye worm) calpain 5 0.0028 0.0229 0.0342
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0035
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0012 0.0023 0.0036
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0002 0.0007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0241 0.0359
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Onchocerca volvulus 0.0017 0.0079 0.0272
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0002 0.0007
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0012 0.0023 0.0075
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0186 0.2228 0.3324
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0002 0.0003
Schistosoma mansoni Mername-AA248 (C02 family) 0.0041 0.0385 0.0574
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474
Loa Loa (eye worm) hypothetical protein 0.0017 0.008 0.012
Echinococcus granulosus neuroendocrine convertase 2 0.0017 0.0079 0.0278
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0013 0.003 0.0053
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0013 0.0037 0.0103
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0073 0.0073
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0322 0.9036
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0048 0.0135
Brugia malayi calpain family protein 1 0.0108 0.1238 0.1847
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0318 0.1117
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0241 0.07
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Brugia malayi endoprotease bli-4 precursor 0.0017 0.0079 0.0118
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0037 0.0073
Echinococcus multilocularis calpain family protein 1, d 0.0079 0.0877 0.0877
Toxoplasma gondii subtilisin SUB5 0.0017 0.0079 0.0225
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0017 0.0079 0.0272
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0333 0.1172
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0022 0.0032
Schistosoma mansoni multidrug resistance protein 0.0011 0.0002 0.0003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0192
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0111 0.3069
Echinococcus multilocularis neuroendocrine convertase 2 0.0017 0.0079 0.0079
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0322 0.1132
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0036
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.005 0.0074
Loa Loa (eye worm) subtilase 0.0538 0.6704 1
Schistosoma mansoni hypothetical protein 0.0048 0.0474 0.0706
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0111 0.0165
Toxoplasma gondii subtilisin SUB1 0.0017 0.0079 0.0225
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0322 0.1134
Echinococcus granulosus dna polymerase kappa 0.0019 0.0111 0.039
Plasmodium vivax calpain, putative 0.0041 0.0385 0.1122
Schistosoma mansoni hypothetical protein 0.0167 0.1985 0.2961
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0013 0.0037 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0385 0.1026
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0073 0.0207
Onchocerca volvulus 0.0035 0.0318 0.1117
Loa Loa (eye worm) hypothetical protein 0.0061 0.0642 0.0958
Mycobacterium tuberculosis Probable peptidase 0.0051 0.051 0.1491
Brugia malayi prolyl oligopeptidase family protein 0.0013 0.0037 0.0056
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.122 0.3314
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0318 0.1117
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0509 0.1487
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0022 0.0022
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0002 0.0007
Leishmania major hypothetical protein, conserved 0.0023 0.0157 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0241 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0079 0.0272
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0401 0.1071
Onchocerca volvulus 0.0012 0.0022 0.007
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0012 0.0023 0.0058
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0073 0.0171
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0207 0.0309
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1679 0.2504
Echinococcus multilocularis musashi 0.0027 0.0207 0.0207
Loa Loa (eye worm) calpain family protein 1 0.0108 0.1238 0.1847
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0356 1
Echinococcus multilocularis caspase 2 0.0061 0.0642 0.0642
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0111 0.0297
Schistosoma mansoni intermediate filament proteins 0.0027 0.0207 0.0309
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0013 0.0037 0.0074
Plasmodium falciparum thioredoxin reductase 0.0016 0.0073 0.0207
Schistosoma mansoni ets-related 0.0218 0.2635 0.3931
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0322 0.1132
Loa Loa (eye worm) trypsin family protein 0.0012 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0003
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0037 0.0123
Trypanosoma brucei kinesin, putative 0.0028 0.0229 0.06
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.122 0.3314
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1216 0.3559
Schistosoma mansoni lamin 0.0027 0.0207 0.0309
Leishmania major hypothetical protein, conserved 0.0012 0.0023 0.0058
Mycobacterium ulcerans hypothetical protein 0.0023 0.0157 0.0398
Brugia malayi beta-lactamase 0.0035 0.0318 0.0474
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0012 0.0023 0.0036
Onchocerca volvulus 0.0061 0.0642 0.2266
Brugia malayi multidrug resistance protein 3 0.0011 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0201 0.03
Toxoplasma gondii hypothetical protein 0.0048 0.048 0.14
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0013 0.0037 0.0074
Echinococcus granulosus calpain 0.0041 0.0385 0.1356
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0017 0.0079 0.0118
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0013 0.0037 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0459 0.1228
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0037 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0073 0.0171
Leishmania major trypanothione reductase 0.0046 0.0459 0.1248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Echinococcus granulosus calpain 7 C02 family 0.0041 0.0385 0.1356
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.1484 0.2213
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0509 0.1366
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0459 0.1339
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1371 0.2045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0102 0.0293
Trypanosoma brucei trypanothione reductase 0.0046 0.0459 0.1228
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1914 0.2855
Trypanosoma brucei Calpain-like protein 1.2 0.0012 0.0023 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0073 0.015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0022 0.0032
Schistosoma mansoni hypothetical protein 0.0186 0.2228 0.3324
Echinococcus multilocularis prolyl endopeptidase 0.0127 0.1484 0.1484
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0642 0.2266
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0017 0.0079 0.0118
Loa Loa (eye worm) acetyltransferase 0.0142 0.1679 0.2504
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0385 0.1026
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0037 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0073 0.0171
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0111 0.0275
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0356 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0111 0.0275
Echinococcus granulosus acylamino acid releasing enzyme 0.0013 0.0037 0.0131
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0318 0.0925
Plasmodium falciparum peptidase, putative 0.0013 0.0037 0.0103
Echinococcus granulosus apoptotic protease activating factor 1 0.0061 0.0642 0.2263
Echinococcus multilocularis enteropeptidase 0.0012 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0037 0.0124
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0002 0.0007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0318 0.0474
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0111 0.0275
Brugia malayi proprotein convertase 2 0.0017 0.0079 0.0118
Schistosoma mansoni hypothetical protein 0.0012 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0096 0.1083 0.1615
Echinococcus granulosus enteropeptidase 0.0012 0.0022 0.0077
Schistosoma mansoni furin-1 (S08 family) 0.0017 0.0079 0.0118
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0333 0.0779
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0241 0.0241
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1914 0.6745
Echinococcus granulosus dna polymerase eta 0.0019 0.0111 0.039
Leishmania major hypothetical protein, conserved 0.0035 0.0318 0.0862
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1866 0.5466
Schistosoma mansoni calpain (C02 family) 0.0041 0.0385 0.0574
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0186 0.2228 0.2228
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.1484 0.2213
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0186 0.2228 0.3324
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0038
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0333 0.0333
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0318 0.0842
Treponema pallidum polypeptide deformylase (def) 0.0279 0.3412 1
Onchocerca volvulus 0.0012 0.0022 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0318 0.0474

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 168 nM Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus ChEMBL. 15006385
IC50 (binding) = 168 nM Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus ChEMBL. 15006385

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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