Detailed information for compound 570228

Basic information

Technical information
  • TDR Targets ID: 570228
  • Name: 2-[4-(3-hydroxyiminocyclohexyl)phenyl]propano ic acid
  • MW: 261.316 | Formula: C15H19NO3
  • H donors: 2 H acceptors: 3 LogP: 2.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON=C1CCCC(C1)c1ccc(cc1)C(C(=O)O)C
  • InChi: 1S/C15H19NO3/c1-10(15(17)18)11-5-7-12(8-6-11)13-3-2-4-14(9-13)16-19/h5-8,10,13,19H,2-4,9H2,1H3,(H,17,18)
  • InChiKey: IQPPOXSMSDPZKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-(3-hydroximinocyclohexyl)phenyl]propionic acid
  • ximoprofen

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0269 0.3191
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.077 0.1106
Brugia malayi MBOAT family protein 0.0042 0.0823 0.1186
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0071 0.0037
Echinococcus multilocularis Mastin 0.0039 0.077 0.077
Echinococcus granulosus enteropeptidase 0.0039 0.077 0.077
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0269 0.0236
Onchocerca volvulus 0.0033 0.0613 0.4797
Toxoplasma gondii hypothetical protein 0.0034 0.0648 0.0794
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0121 0.2722 0.4043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0071 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Trichomonas vaginalis porcupine, putative 0.0042 0.0823 1
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.9616 0.9616
Echinococcus granulosus transmembrane protease serine 3 0.0039 0.077 0.077
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0071 0.0012
Onchocerca volvulus 0.0034 0.0648 0.5091
Leishmania major hypothetical protein, conserved 0.0042 0.0823 0.5937
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Brugia malayi Bromodomain containing protein 0.008 0.1748 0.2577
Brugia malayi Cytochrome P450 family protein 0.0018 0.0269 0.0353
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0269 0.3191
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0071 0.0056
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0823 0.6429
Plasmodium falciparum cysteine repeat modular protein 1 0.0059 0.124 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0937 0.0906
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0269 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0823 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0071 0.0309
Loa Loa (eye worm) hypothetical protein 0.004 0.0791 0.0759
Brugia malayi hypothetical protein 0.0019 0.0278 0.0368
Onchocerca volvulus 0.0034 0.0648 0.5091
Leishmania major glycerol uptake protein, putative 0.0042 0.0823 0.5937
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0823 0.0823
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0042 0.0823 0.0823
Echinococcus granulosus zinc finger protein 0.0022 0.0359 0.0359
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0269 0.3191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0245
Onchocerca volvulus 0.0033 0.0613 0.4797
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0059 0.124 1
Brugia malayi MBOAT family protein 0.0042 0.0823 0.1186
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0269 0.169
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0269 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0071 0.0037
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0269 0.0269
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0257 0.0257
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0278 0.0368
Treponema pallidum alginate O-acetylation protein (algI) 0.0042 0.0823 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0071 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0071 0.0037
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0269 0.3191
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0042 0.0823 0.0823
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0303 0.0303
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0823 0.0823
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0042 0.0823 0.6457
Schistosoma mansoni thyroid hormone receptor 0.001 0.0071 0.0071
Onchocerca volvulus 0.0033 0.0613 0.4797
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0823 0.0823
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0269 0.169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0071 0.0071
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0303 0.0405
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0269 0.0236
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0303 0.0884
Schistosoma mansoni zinc finger protein 0.0022 0.0359 0.0359
Schistosoma mansoni cpg binding protein 0.0029 0.0516 0.0516
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0269 0.169
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0071 0.0071
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0042 0.0823 0.0823
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.013
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0648 0.0794
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0245
Leishmania major glycerol uptake protein, putative 0.0042 0.0823 0.5937
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0269 0.3191
Toxoplasma gondii PAN/Apple domain-containing protein 0.0034 0.0648 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0823 1
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0042 0.0823 0.0823
Schistosoma mansoni cpg binding protein 0.0032 0.0603 0.0603
Trypanosoma cruzi ISWI complex protein 0.0016 0.0213 0.1211
Schistosoma mansoni hypothetical protein 0.0409 0.9616 0.9616
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0121 0.2722 0.2722
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0516 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.124 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0269 1
Onchocerca volvulus 0.0034 0.0648 0.5091
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0269 0.3191
Loa Loa (eye worm) hhat protein 0.0042 0.0823 0.0792
Loa Loa (eye worm) hypothetical protein 0.0043 0.085 0.0819
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0823 0.6429
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Echinococcus multilocularis cpg binding protein 0.0032 0.0603 0.0603
Brugia malayi ecdysteroid receptor 0.001 0.0071 0.0056
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0303 0.0303
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0303 0.3418
Loa Loa (eye worm) hypothetical protein 0.0042 0.0823 0.0792
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Brugia malayi nuclear hormone receptor 0.001 0.0071 0.0056
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0071 0.0071
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0648 0.0794
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0823 0.0792
Schistosoma mansoni hypothetical protein 0.0016 0.0213 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0269 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0269 1
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0071 0.0071
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0823 0.3002
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Onchocerca volvulus 0.0059 0.124 1
Onchocerca volvulus 0.0042 0.0823 0.6539
Brugia malayi hypothetical protein 0.0014 0.0164 0.0195
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0033 0.0613 0.0581
Loa Loa (eye worm) hypothetical protein 0.0042 0.0823 0.0792
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0042 0.0823 0.0792
Onchocerca volvulus 0.0034 0.0648 0.5091
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0042 0.0823 0.0823
Toxoplasma gondii hypothetical protein 0.0034 0.0648 0.0794
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.119 0.1528
Onchocerca volvulus 0.0033 0.0613 0.4797
Onchocerca volvulus 0.0039 0.077 0.6098
Loa Loa (eye worm) hypothetical protein 0.0121 0.2731 0.2706
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0278 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0071 0.0037
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0269 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Entamoeba histolytica recQ family DNA helicase 0.001 0.0071 0.0121
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Schistosoma mansoni DNA helicase recq5 0.002 0.0303 0.0303
Toxoplasma gondii microneme protein, putative 0.0034 0.0648 0.0794
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0087 0.008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0071 0.0071
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0269 0.0276
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0269 1
Toxoplasma gondii PAN domain-containing protein 0.0319 0.745 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0269 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0272 0.0238
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0648 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0071 0.0056
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0823 0.6429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0071 0.0037
Loa Loa (eye worm) RecQ helicase 0.002 0.0303 0.0271
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0303 0.0303
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0269 0.3191
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0121 0.2722 0.2697
Loa Loa (eye worm) hypothetical protein 0.0033 0.0613 0.0581
Loa Loa (eye worm) cytochrome P450 0.0018 0.0269 0.0236
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Echinococcus granulosus tissue type plasminogen activator 0.0059 0.124 0.124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0071 0.0037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0071 0.0071
Schistosoma mansoni zinc finger protein 0.0042 0.0823 0.0823
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0042 0.0823 0.0792
Leishmania major cytochrome p450-like protein 0.0018 0.0269 0.0545
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0042 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Brugia malayi Trypsin-like protease protein 5 0.0039 0.077 0.1106
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0121 0.2722 0.2722
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0269 0.3191
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0269 0.3191
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0823 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0213 0.1211
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0059 0.124 1
Brugia malayi hypothetical protein 0.0039 0.077 0.1106
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0101 0.2245 0.2245
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0433 0.0433
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0613 0.087
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0269 0.3191
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0071 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0269 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0042 0.0823 0.0823
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0042 0.0823 0.0823
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0269 0.3191
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0303 0.0447
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Loa Loa (eye worm) hypothetical protein 0.0425 1 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.0278 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0071 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0071 0.0056
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.002 0.0303 0.0271
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Brugia malayi MBOAT family protein 0.0042 0.0823 0.1186
Toxoplasma gondii hypothetical protein 0.0042 0.0823 0.103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.073 0.073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0071 0.0071
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0071 0.0056
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0269 0.3191
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Echinococcus granulosus cpg binding protein 0.0032 0.0603 0.0603
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0042
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0269 0.0545
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0164 0.1644
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0269 0.3191
Brugia malayi Cytochrome P450 family protein 0.0018 0.0269 0.0353
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0121 0.2722 0.2722
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0433 0.0433
Brugia malayi Hhat protein 0.0042 0.0823 0.1186
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0269 0.169
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0042 0.0823 0.0823
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0269 0.3191
Schistosoma mansoni coup transcription factor 0.001 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0071 0.0056
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0269 0.3191
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0042
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0269 0.3191
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0245
Schistosoma mansoni hypothetical protein 0.0039 0.077 0.077
Toxoplasma gondii microneme protein MIC17B 0.0034 0.0648 0.0794
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0272 0.0272
Brugia malayi MBOAT family protein 0.0042 0.0823 0.1186
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0648 0.0616
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0613 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0071 0.0071
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0269 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0071 0.0071
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0257 0.0257
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0269 1
Brugia malayi hypothetical protein 0.0019 0.0278 0.0368
Leishmania major glycerol uptake protein, putative 0.0042 0.0823 0.5937
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0071 0.0309
Brugia malayi Trypsin family protein 0.0039 0.077 0.1106
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.0278 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0071 0.0056
Toxoplasma gondii PAN domain-containing protein 0.0319 0.745 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0071 0.0078
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0648 0.0616
Leishmania major glycerol uptake protein, putative 0.0042 0.0823 0.5937
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0071 0.0056
Leishmania major cytochrome p450-like protein 0.0018 0.0269 0.0545
Schistosoma mansoni hypothetical protein 0.0042 0.0823 0.0823
Toxoplasma gondii microneme protein MIC17C 0.0034 0.0648 0.0794
Onchocerca volvulus 0.0039 0.077 0.6098
Echinococcus granulosus bloom syndrome protein 0.002 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0022 0.0346 0.0346
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0062 0.0062
Schistosoma mansoni bromodomain containing protein 0.0068 0.1454 0.1454
Echinococcus multilocularis transmembrane protease serine 3 0.0039 0.077 0.077
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0042 0.0823 0.103
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Schistosoma mansoni DNA helicase recq1 0.002 0.0303 0.0303
Brugia malayi Cytochrome P450 family protein 0.0018 0.0269 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0071 0.0056
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0823 1
Onchocerca volvulus 0.0039 0.077 0.6098
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0278 0.0368
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0042 0.0823 0.5543
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0303 0.0327
Brugia malayi MBOAT family protein 0.0042 0.0823 0.1186
Echinococcus granulosus dnaJ subfamily B 0.0409 0.9616 0.9616
Onchocerca volvulus 0.0039 0.077 0.6098
Brugia malayi Trypsin family protein 0.0039 0.077 0.1106
Echinococcus granulosus Mastin 0.0039 0.077 0.077
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0269 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0071 0.0056
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0042 0.0823 0.0823
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.073 0.073
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0269 0.3191
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0303 0.0271
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0823 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0059 0.124 0.124
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0269 0.3191
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0648 0.0794
Brugia malayi Trypsin family protein 0.0039 0.077 0.1106
Brugia malayi PHD-finger family protein 0.0028 0.0493 0.069
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.077 0.077
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0039 0.077 0.077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0071 0.0071
Onchocerca volvulus 0.0014 0.0164 0.1075
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0071 0.0309
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0071 0.0071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0303 0.0327
Schistosoma mansoni cytochrome P450 0.0018 0.0269 0.0269
Schistosoma mansoni sterol O-acyltransferase 1 0.0425 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0071 0.0071
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0384 0.9007 0.9003
Brugia malayi steroid hormone receptor 0.001 0.0071 0.0056
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0346 0.0313
Trichomonas vaginalis transmembrane protein nessy, putative 0.0042 0.0823 1
Echinococcus multilocularis enteropeptidase 0.0039 0.077 0.077
Onchocerca volvulus 0.0039 0.077 0.6098
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0121 0.2722 0.2722
Brugia malayi nuclear receptor NHR-88 0.001 0.0071 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0071 0.0056
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0257 0.0257
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0071 0.0056
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0269 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0823 1
Toxoplasma gondii kringle domain-containing protein 0.0059 0.124 0.1595
Onchocerca volvulus 0.0034 0.0648 0.5091
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0269 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0425 1 1
Onchocerca volvulus 0.0034 0.0648 0.5091
Onchocerca volvulus 0.0029 0.0516 0.4
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Entamoeba histolytica recQ family helicase, putative 0.002 0.0303 0.3176
Schistosoma mansoni zinc finger protein 0.0016 0.0213 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0269 1
Onchocerca volvulus 0.0039 0.077 0.6098
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0823 0.0823
Onchocerca volvulus 0.0019 0.0278 0.2026
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0071 0.0071
Brugia malayi CXXC zinc finger family protein 0.0029 0.0516 0.0726
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0042 0.0823 0.0823
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0303 0.1988
Echinococcus granulosus glycoprotein Antigen 5 0.0039 0.077 0.077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.1364 0.1364
Loa Loa (eye worm) trypsin family protein 0.0039 0.077 0.0738
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0042 0.0823 0.0823
Onchocerca volvulus 0.0033 0.0613 0.4797
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0042 0.0823 0.0792
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0039 0.077 0.077
Onchocerca volvulus 0.0034 0.0648 0.5091
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0303 0.0405
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0648 0.0616
Loa Loa (eye worm) hypothetical protein 0.0074 0.1601 0.1573
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0042 0.0823 0.0823
Onchocerca volvulus 0.0034 0.0648 0.5091
Trypanosoma cruzi GUP1, putative 0.0042 0.0823 0.6429
Trypanosoma brucei RNA helicase, putative 0.0101 0.2245 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0269 1
Schistosoma mansoni hypothetical protein 0.0018 0.0269 0.0269
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0303 0.0405
Mycobacterium ulcerans hypothetical protein 0.0039 0.077 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0269 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0272 0.0239
Brugia malayi Cytochrome P450 family protein 0.0018 0.0269 0.0353
Brugia malayi hypothetical protein 0.0287 0.6683 1
Mycobacterium leprae putative cytochrome p450 0.0018 0.0269 0.5
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0033 0.0613 0.087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0269 0.3191
Entamoeba histolytica vacuolar protein sorting 26 0.0042 0.0823 1
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0648 0.0616
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0823 0.0792
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0823 0.0823
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0071 0.0071
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0042 0.0823 0.0823
Onchocerca volvulus 0.0019 0.0278 0.2026
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0269 0.0276
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0269 0.028
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Echinococcus multilocularis tissue type plasminogen activator 0.0059 0.124 0.124
Toxoplasma gondii microneme protein MIC17A 0.0034 0.0648 0.0794
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.124 0.121
Echinococcus granulosus FTZ F1 alpha 0.001 0.0071 0.0071
Leishmania major glycerol uptake protein, putative 0.0042 0.0823 0.5937
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0071 0.0056
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0648 0.0616
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Brugia malayi LBP/BPI 0.0014 0.0164 0.0195
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1287 0.1287
Schistosoma mansoni hypothetical protein 0.0039 0.077 0.077
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0071 0.0037
Loa Loa (eye worm) hypothetical protein 0.0014 0.0164 0.013
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0269 1
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0269 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.077 0.077
Brugia malayi Protein kinase domain containing protein 0.0059 0.124 0.1814
Onchocerca volvulus 0.0034 0.0648 0.5091
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0034 0.0648 0.0794
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0303 0.3418
Brugia malayi Kringle domain containing protein 0.0059 0.124 0.1814
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0042 0.0823 0.103
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0269 0.0236
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0121 0.2722 0.2722
Onchocerca volvulus 0.0033 0.0613 0.4797
Schistosoma mansoni thyroid hormone receptor 0.001 0.0071 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0071 0.0071
Schistosoma mansoni cpg binding protein 0.0032 0.0603 0.0603
Onchocerca volvulus 0.0034 0.0648 0.5091
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0823 0.0792
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Loa Loa (eye worm) hhat protein 0.0042 0.0823 0.0792
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Echinococcus multilocularis bloom syndrome protein 0.002 0.0303 0.0303
Echinococcus multilocularis 0.0018 0.0269 0.0269
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0303 0.3418
Leishmania major cytochrome p450-like protein 0.0018 0.0269 0.0545
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.077 0.077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0272 0.0272
Onchocerca volvulus 0.001 0.0071 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0272 0.0272
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0823 0.0823
Schistosoma mansoni nuclear hormone receptor 0.001 0.0071 0.0071
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0823 0.0823
Brugia malayi Bromodomain containing protein 0.004 0.0789 0.1135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0071 0.0071
Onchocerca volvulus 0.0033 0.0613 0.4797
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0272 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0071 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0269 0.3191
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0269 1
Onchocerca volvulus 0.0033 0.0613 0.4797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0278 0.0245
Brugia malayi Trypsin family protein 0.0039 0.077 0.1106
Echinococcus multilocularis zinc finger protein 0.0022 0.0359 0.0359
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0039 0.077 0.077
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0269 0.3191
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0269 1
Brugia malayi diacylglycerol acyltransferase 0.0042 0.0823 0.1186
Loa Loa (eye worm) hypothetical protein 0.0059 0.124 0.121
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0823 0.0823
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0071 0.0071
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0433 0.0433
Echinococcus multilocularis glycoprotein Antigen 5 0.0039 0.077 0.077
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0071 0.0071
Toxoplasma gondii subtilisin SUB12 0.0034 0.0648 0.0794
Loa Loa (eye worm) hypothetical protein 0.0039 0.077 0.0738
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0823 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0071 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0648 0.0616
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.1364 0.1364
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0269 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0823 1
Toxoplasma gondii microneme protein MIC4 0.0034 0.0648 0.0794
Brugia malayi PAN domain containing protein 0.0034 0.0648 0.0924
Brugia malayi cytochrome P450 0.0018 0.0269 0.0353
Entamoeba histolytica hypothetical protein 0.0042 0.0823 1
Onchocerca volvulus 0.0034 0.0648 0.5091
Loa Loa (eye worm) hypothetical protein 0.001 0.0071 0.0037
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0823 0.3002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0257 0.0257
Trypanosoma cruzi GUP1, putative 0.0042 0.0823 0.6429
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0269 0.169

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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