Detailed information for compound 57635

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.395 | Formula: C18H23N3
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1nc2ccccc2c2c1CCCC2
  • InChi: 1S/C18H23N3/c1-20-10-12-21(13-11-20)18-16-8-3-2-6-14(16)15-7-4-5-9-17(15)19-18/h4-5,7,9H,2-3,6,8,10-13H2,1H3
  • InChiKey: WLVCZYGIAIOYFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic References
Rattus norvegicus Serotonin transporter Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic References
Rattus norvegicus Serotonin 2c (5-HT2c) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 2a (5-HT2a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Echinococcus multilocularis serotonin receptor Serotonin 1b (5-HT1b) receptor   386 aa 393 aa 32.3 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Brugia malayi GnHR receptor homolog Serotonin 1b (5-HT1b) receptor   386 aa 335 aa 21.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 354 aa 20.1 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Serotonin transporter   630 aa 520 aa 36.2 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Serotonin 2a (5-HT2a) receptor   471 aa 435 aa 23.0 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.0 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Plasmodium knowlesi transporter, putative Serotonin transporter   630 aa 514 aa 20.2 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 552 aa 41.5 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Plasmodium vivax hypothetical protein, conserved Serotonin transporter   630 aa 528 aa 21.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1b (5-HT1b) receptor   386 aa 310 aa 21.6 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Serotonin 1b (5-HT1b) receptor   386 aa 371 aa 26.1 %
Brugia malayi Cation transporter family protein 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 484 aa 469 aa 28.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Toxoplasma gondii Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 509 aa 28.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Brugia malayi Cation transporter family protein 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic 404 aa 445 aa 22.0 %
Onchocerca volvulus Transmembrane protein 120 homolog Serotonin transporter   630 aa 571 aa 31.2 %
Onchocerca volvulus Serotonin 1b (5-HT1b) receptor   386 aa 363 aa 34.4 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Schistosoma mansoni biogenic amine (5HT) receptor Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 33.4 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus multilocularis sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 332 aa 21.7 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 582 aa 35.2 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Serotonin transporter   630 aa 581 aa 40.1 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Brugia malayi sulfakinin receptor protein Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 23.3 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Serotonin transporter   630 aa 638 aa 25.1 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus granulosus neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Serotonin 1b (5-HT1b) receptor   386 aa 355 aa 24.2 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 30.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Onchocerca volvulus Phospholipase d-related homolog Serotonin 1b (5-HT1b) receptor   386 aa 350 aa 18.6 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Serotonin 1b (5-HT1b) receptor   386 aa 359 aa 22.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Onchocerca volvulus Forkhead box protein biniou homolog Serotonin 1b (5-HT1b) receptor   386 aa 333 aa 21.3 %
Echinococcus multilocularis neuropeptide receptor Serotonin 1b (5-HT1b) receptor   386 aa 331 aa 21.4 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Echinococcus granulosus dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Brugia malayi Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 30.9 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma mansoni dro/myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 334 aa 24.0 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Serotonin transporter   630 aa 576 aa 31.8 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Schistosoma mansoni sodium/chloride dependent transporter Serotonin transporter   630 aa 605 aa 37.7 %
Echinococcus granulosus sodium and chloride dependent glycine Serotonin transporter   630 aa 617 aa 39.4 %
Onchocerca volvulus Serotonin transporter   630 aa 611 aa 26.4 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Serotonin transporter   630 aa 585 aa 34.2 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Echinococcus multilocularis dro:myosuppressin receptor Serotonin 1b (5-HT1b) receptor   386 aa 349 aa 18.6 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Serotonin transporter   630 aa 629 aa 47.1 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.0645
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0296 0.2202
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0291 0.2897 0.4513
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0099 0.0137
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.0265 0.0265
Brugia malayi conserved hypotetical protein 0.0137 0.1195 0.1862
Echinococcus multilocularis ecdysone induced protein 78C 0.0291 0.2897 0.2897
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0035 0.0068 0.0068
Schistosoma mansoni jun-related protein 0.0139 0.1214 0.1683
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni nuclear receptor 0.0137 0.1195 0.1657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi nuclear hormone receptor 0.0291 0.2897 0.4513
Loa Loa (eye worm) hypothetical protein 0.0032 0.0034 0.0082
Echinococcus granulosus pyruvate kinase 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0315
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0255 0.2506 0.2506
Echinococcus granulosus RUN 0.0041 0.0133 0.0133
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Brugia malayi Death domain containing protein 0.0029 0.000000018783 0.00000002926
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.0265 0.0628
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0055 0.0131
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus Ankyrin 0.0029 0.0003 0.0003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus multilocularis neuropeptide receptor A26 0.0053 0.0265 0.0265
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi photoreceptor-specific nuclear receptor 0.0291 0.2897 0.4513
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Brugia malayi ecdysone receptor 0.0137 0.1195 0.1862
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi steroid hormone receptor 0.0291 0.2897 0.4513
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.041 0.4221 1
Loa Loa (eye worm) serotonin transporter b 0.033 0.3327 0.7882
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0645 0.0645
Echinococcus multilocularis jun protein 0.0171 0.1568 0.1568
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0056 0.0296 0.0296
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.0265 0.0367
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.039 0.0965
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Echinococcus multilocularis nAChR subunit 0.0053 0.026 0.026
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0051 0.0135
Plasmodium vivax amine transporter, putative 0.0056 0.0296 0.2202
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0291 0.2897 0.2897
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.0051 0.0051
Trichomonas vaginalis glutaminase, putative 0.0269 0.266 0.4396
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.0265 0.0413
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Giardia lamblia Hypothetical protein 0.0035 0.0068 0.0057
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0265 0.0628
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0087 0.0645 0.1004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0053 0.0265 0.0796
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0291 0.2897 0.2897
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.039 0.2995
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0068 0.0068
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0087 0.0645 0.0894
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0137 0.1195 0.1657
Schistosoma mansoni hypothetical protein 0.039 0.3993 0.5535
Brugia malayi bZIP transcription factor family protein 0.0171 0.1568 0.2443
Echinococcus multilocularis geminin 0.0331 0.3346 0.3346
Onchocerca volvulus Putative nachr subunit 0.0087 0.0645 0.1938
Echinococcus multilocularis serotonin receptor 0.02 0.1894 0.1894
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) acetylcholine receptor protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.0265 0.0628
Echinococcus granulosus allatostatin A receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0068 0.0068
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.0265 0.0628
Toxoplasma gondii hypothetical protein 0.0056 0.0296 0.0913
Echinococcus granulosus jun protein 0.0171 0.1568 0.1568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Schistosoma mansoni hypothetical protein 0.006 0.0345 0.0478
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0035 0.0068 0.0106
Schistosoma mansoni nuclear hormone receptor 0.0291 0.2897 0.4016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus multilocularis dihydrofolate reductase 0.0365 0.3717 0.3717
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0035 0.0068 0.0068
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0112 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis pyruvate kinase 0.0032 0.0034 0.0034
Schistosoma mansoni peroxidasin 0.0081 0.0576 0.0798
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0255 0.2506 0.2506
Echinococcus multilocularis serotonin receptor 0.02 0.1894 0.1894
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.1335 0.1335
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Echinococcus multilocularis somatostatin receptor 0.0053 0.0265 0.0265
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0291 0.2897 0.2897
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0154 0.1378 0.1378
Brugia malayi larval opioid receptor 0.0053 0.0265 0.0413
Schistosoma mansoni peroxidasin 0.0081 0.0576 0.0798
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0291 0.2897 0.2897
Loa Loa (eye worm) dihydrofolate reductase 0.0365 0.3717 0.8806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0265 0.0265
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0133 0.0829
Brugia malayi jmjC domain containing protein 0.0093 0.0702 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0212 0.0501
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0265 0.0265
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0061 0.0084
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.0265 0.0413
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni histamine h1 receptor 0.0053 0.0265 0.0367
Onchocerca volvulus 0.0035 0.0061 0.0182
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0053 0.026 0.036
Echinococcus granulosus serotonin transporter 0.033 0.3327 0.3327
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.041 0.4221 0.5852
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Brugia malayi Nuclear hormone receptor-like 1 0.0291 0.2897 0.4513
Onchocerca volvulus 0.0053 0.026 0.0782
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Onchocerca volvulus 0.0035 0.0061 0.0182
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Schistosoma mansoni hypothetical protein 0.0331 0.3346 0.4639
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Treponema pallidum fructose-bisphosphate aldolase 0.0571 0.6007 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.0265 0.0265
Brugia malayi Uncoordinated protein 44 0.0029 0.000000018783 0.00000002926
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0291 0.2897 0.4016
Schistosoma mansoni polycystin 1-related 0.0041 0.0133 0.0184
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Onchocerca volvulus 0.0087 0.0645 0.1938
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Brugia malayi G-protein coupled receptor 0.0053 0.0265 0.0413
Echinococcus multilocularis neuropeptide s receptor 0.0053 0.0265 0.0265
Brugia malayi Doublecortin family protein 0.0041 0.0133 0.0207
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0291 0.2897 0.4513
Brugia malayi ORL1-like opioid receptor 0.0053 0.0265 0.0413
Schistosoma mansoni lipoxygenase 0.0106 0.0849 0.1176
Loa Loa (eye worm) nuclear receptor NHR-67 0.0137 0.1195 0.2832
Schistosoma mansoni loxhd1 0.0041 0.0133 0.0184
Onchocerca volvulus 0.0053 0.0265 0.0796
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) solute carrier family 6 member 4 0.033 0.3327 0.7882
Brugia malayi nuclear receptor NHR-88 0.0137 0.1195 0.1862
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0055 0.0055
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.0265 0.0265
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Echinococcus granulosus somatostatin receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 0.4144
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.041 0.4221 1
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0265 0.0628
Brugia malayi nuclear hormone receptor family member nhr-6 0.0137 0.1195 0.1862
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0087 0.0645 0.0894
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.01
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.0265 0.0265
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) GABA receptor subunit 0.0053 0.026 0.0616
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0051 0.0135
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.039 0.3993 0.3993
Schistosoma mansoni hypothetical protein 0.0038 0.0099 0.0137
Onchocerca volvulus 0.0041 0.0133 0.0399
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0645 0.0645
Echinococcus multilocularis orexin receptor type 2 0.0053 0.0265 0.0265
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0255 0.2506 0.3904
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Schistosoma mansoni thyroid hormone receptor 0.068 0.7214 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Brugia malayi Serotonin/octopamine receptor family protein 7 0.041 0.4221 0.6576
Toxoplasma gondii hypothetical protein 0.0056 0.0296 0.0913
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0112 0.0112
Onchocerca volvulus 0.0087 0.0645 0.1938
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0099 0.0099
Onchocerca volvulus 0.0087 0.0645 0.1938
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0035 0.0068 0.0068
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0048 0.0213 0.0505
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0491 0.0681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0291 0.2897 0.4513
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0035 0.0068 0.0068
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.0265 0.0265
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Onchocerca volvulus Chorion peroxidase homolog 0.0081 0.0576 0.1731
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.0265 0.0265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0053 0.0265 0.0796
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0702 0.0702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0279 0.2769 0.7424
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0154 0.1378 0.191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.018 0.1671 0.1671
Echinococcus granulosus sex peptide receptor 0.0053 0.0265 0.0265
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0133 0.0133
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.0265 0.0628
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.0265 0.0367
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) norepinephrine transporter 0.033 0.3327 0.7882
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Loa Loa (eye worm) hypothetical protein 0.0166 0.1516 0.3592
Echinococcus multilocularis thyroid hormone receptor alpha 0.068 0.7214 0.7214
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.0265 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0291 0.2897 0.4513
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0265 0.0265
Echinococcus granulosus hypothetical protein 0.0053 0.0265 0.0265
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1195 0.3593
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0291 0.2897 0.2897
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0034 0.0082
Brugia malayi jmjC domain containing protein 0.0034 0.0055 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0291 0.2899 1
Brugia malayi putative neuropeptide receptor 0.0053 0.0265 0.0413
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.0265 0.0265
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0291 0.2897 0.2897
Brugia malayi ecdysteroid receptor 0.0291 0.2897 0.4513
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0365 0.3717 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Onchocerca volvulus Protein ultraspiracle homolog 0.0291 0.2897 0.8707
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Echinococcus multilocularis sex peptide receptor 0.0053 0.0265 0.0265
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Schistosoma mansoni zinc finger protein 0.0137 0.1195 0.1657
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni nAChR subunit 0.0035 0.0061 0.0084
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0291 0.2897 0.4513
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Brugia malayi hypothetical protein 0.0154 0.1378 0.2146
Echinococcus granulosus fmrfamide receptor 0.0053 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.0265 0.0628
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.039 0.3993 0.3993
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0285
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0035 0.0068 0.0285
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0035 0.0061 0.0061
Echinococcus granulosus neuropeptide receptor 0.0053 0.0265 0.0265
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0087 0.0645 0.1004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0345 0.0817
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Echinococcus multilocularis Ankyrin 0.0029 0.0003 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0212 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0087 0.0645 0.0645
Schistosoma mansoni myosin xvIII 0.0053 0.0265 0.0367
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.000000018783 0.000000018783
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni opsin-like receptor 0.0053 0.0265 0.0367
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis serotonin transporter 0.033 0.3327 0.3327
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Brugia malayi hypothetical protein 0.0041 0.0133 0.0207
Chlamydia trachomatis dihydrofolate reductase 0.0365 0.3717 1
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.0265 0.0265
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0139 0.1221 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Schistosoma mansoni hypothetical protein 0.0053 0.0265 0.0367
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.033 0.3327 0.4612
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.0265 0.0413
Plasmodium vivax phosphodiesterase gamma, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0291 0.2897 0.4513
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0087 0.0645 0.1527
Schistosoma mansoni rab6-interacting 0.0041 0.0133 0.0184
Schistosoma mansoni coup transcription factor 0.0291 0.2897 0.4016
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus 0.0041 0.0133 0.0399
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Schistosoma mansoni acetylcholine receptor subunit beta 0.0035 0.0061 0.0084
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) glutaminase 2 0.0269 0.266 0.6302
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0056 0.0296 0.0296
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Onchocerca volvulus 0.0087 0.0645 0.1938
Brugia malayi dihydrofolate reductase family protein 0.0365 0.3717 0.5791
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0087 0.0645 0.0645
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0291 0.2897 0.4513
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0042 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0035 0.0068 0.0068
Schistosoma mansoni sodium/chloride dependent transporter 0.033 0.3327 0.4612
Loa Loa (eye worm) LGC-31 protein 0.0087 0.0645 0.1527
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0576 0.1731
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus granulosus arachidonate 5 lipoxygenase 0.018 0.1671 0.1671
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.0265 0.0265
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0291 0.2897 0.2897
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0279 0.2769 0.7424
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0087 0.0645 0.0894
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) glutaminase 0.0269 0.266 0.6302
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0056 0.0296 0.0296
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0291 0.2897 0.2897
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0137 0.1195 0.1862
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.0051 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1195 0.1657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0035 0.0068 0.0106
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0087 0.0645 0.0894
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.026 0.0405
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0056 0.0296 0.041
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0095
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0154 0.1378 0.191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0701
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0365 0.3717 1
Brugia malayi Nuclear hormone receptor-like 1 0.0154 0.1378 0.2146
Brugia malayi nuclear hormone receptor 0.0137 0.1195 0.1862
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.039 0.039
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0087 0.0645 0.1527
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.0265 0.0265
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.02 0.1894 0.4487
Onchocerca volvulus 0.0134 0.1162 0.3492
Echinococcus granulosus nAChR subunit 0.0053 0.026 0.026
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0051 0.0135
Echinococcus granulosus dihydrofolate reductase 0.0365 0.3717 0.3717
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.000000018783 0.000000018783
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Echinococcus granulosus neuropeptide receptor A26 0.0053 0.0265 0.0265
Echinococcus granulosus nuclear receptor nhr 48 0.0137 0.1195 0.1195
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0058
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus granulosus nAChR subunit 0.0087 0.0645 0.0645
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0035 0.0061 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0055 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0087 0.0645 0.0645
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0053 0.0265 0.0628
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0291 0.2897 0.4016
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0645 0.0645
Schistosoma mansoni biogenic amine (5HT) receptor 0.02 0.1894 0.2626
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Onchocerca volvulus 0.0053 0.0265 0.0796
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0702 0.0702
Loa Loa (eye worm) hypothetical protein 0.0035 0.0068 0.0162
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.1527
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Brugia malayi Dopamine receptor protein 1 0.0053 0.0265 0.0413
Schistosoma mansoni lipoxygenase 0.018 0.1671 0.2316
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0291 0.2897 0.4513
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.033 0.3327 0.5183
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0645 0.0645
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi Blistered cuticle protein 3 0.0081 0.0576 0.0897
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0035 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0133 0.0315
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi neuropeptide F receptor 0.0053 0.0265 0.0413
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0056 0.0296 0.0461
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0035 0.0068 0.0106
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0035 0.0061 0.0095
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0133 0.0829
Schistosoma mansoni hypothetical protein 0.0331 0.3346 0.4639
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.026 0.0405
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Onchocerca volvulus 0.0056 0.0296 0.0889
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.6007 1
Onchocerca volvulus 0.0053 0.0265 0.0796
Onchocerca volvulus 0.0053 0.0265 0.0796
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0035 0.0061 0.0144
Onchocerca volvulus Peroxidase homolog 0.0081 0.0576 0.1731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0291 0.2897 0.6863
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Brugia malayi tailless protein 0.0137 0.1195 0.1862
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) steroid hormone receptor 0.0291 0.2897 0.6863
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0034 0.0104
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni nuclear receptor nhr-48 0.0137 0.1195 0.1657
Echinococcus multilocularis nAChR subunit 0.0087 0.0645 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0068 0.0057
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0133 0.0133
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Augmenter of liver regeneration 0.0034 0.0051 0.0079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0291 0.2897 0.8707
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0291 0.2897 0.4513
Onchocerca volvulus 0.0053 0.0265 0.0796
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni rab6-interacting 0.0041 0.0133 0.0184
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Loa Loa (eye worm) hypothetical protein 0.0056 0.0296 0.0701
Brugia malayi hypothetical protein 0.0053 0.0265 0.0413
Brugia malayi hypothetical protein 0.0038 0.0099 0.0154
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0087 0.0645 0.1004
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0034 0.0054
Brugia malayi Dihydrofolate reductase 0.0365 0.3717 0.5791
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Echinococcus multilocularis neuropeptide receptor 0.0053 0.0265 0.0265
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0255 0.2506 0.5937
Brugia malayi nuclear receptor RXR 0.0154 0.1378 0.2146
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0087 0.0645 0.0645
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0291 0.2897 0.2897
Brugia malayi G-protein coupled receptor 0.0053 0.0265 0.0413
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0365 0.3717 1
Echinococcus granulosus neuropeptide receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.0265 0.0367
Echinococcus multilocularis glycine receptor subunit beta 0.0087 0.0645 0.0645
Onchocerca volvulus 0.0081 0.0576 0.1731
Onchocerca volvulus Peroxidase homolog 0.0081 0.0576 0.1731
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1195 0.1862
Brugia malayi nuclear receptor RXR 0.0137 0.1195 0.1862
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.039 0.039
Schistosoma mansoni acetylcholine receptor-related 0.0035 0.0061 0.0084
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Brugia malayi nuclear receptor NHR-67 0.0137 0.1195 0.1862
Schistosoma mansoni RAR-like nuclear receptor 0.0291 0.2897 0.4016
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.0265 0.0265
Brugia malayi hypothetical protein 0.0137 0.1195 0.1862
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0137 0.1195 0.3593
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0035 0.0068 0.0106
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0053 0.026 0.036
Echinococcus multilocularis RUN 0.0041 0.0133 0.0133
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Brugia malayi hypothetical protein 0.0081 0.0576 0.0897
Echinococcus granulosus biogenic amine 5HT receptor 0.02 0.1894 0.1894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) ACC-1 protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) blistered cuticle protein 3 0.0081 0.0576 0.1364
Onchocerca volvulus Dual oxidase homolog 0.0081 0.0576 0.1731
Brugia malayi sulfakinin receptor protein 0.0053 0.0265 0.0413
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Brugia malayi excitatory GABA receptor EXP-1A 0.0087 0.0645 0.1004
Echinococcus granulosus orexin receptor type 2 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.0265 0.0265
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0645 0.0645
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0291 0.2897 0.4016
Echinococcus granulosus geminin 0.0331 0.3346 0.3346
Onchocerca volvulus 0.0053 0.0265 0.0796
Brugia malayi GnHR receptor homolog 0.0053 0.0265 0.0413
Onchocerca volvulus 0.0081 0.0576 0.1731
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0291 0.2897 0.4513
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.0265 0.0265
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0035 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Brugia malayi hypothetical protein 0.0056 0.0296 0.0461
Echinococcus granulosus sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0154 0.1378 0.3264
Brugia malayi hypothetical protein 0.0154 0.1378 0.2146
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Echinococcus granulosus g protein coupled receptor 0.0053 0.0265 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0068 0.0285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Schistosoma mansoni hypothetical protein 0.0041 0.0133 0.0184
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.0265 0.0413
Onchocerca volvulus 0.0137 0.1195 0.3593
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0003 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.0291 0.2897 0.2897
Brugia malayi orphan nuclear receptor NR2E1 0.0137 0.1195 0.1862
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0291 0.2897 0.4513
Onchocerca volvulus 0.0053 0.026 0.0782
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.0265 0.0265
Schistosoma mansoni nAChR subunit 0.0035 0.0061 0.0084
Onchocerca volvulus 0.0081 0.0576 0.1731
Brugia malayi nuclear receptor NHR-88 0.0291 0.2897 0.4513
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0056 0.0296 0.0296
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.039 0.1241
Onchocerca volvulus 0.0087 0.0645 0.1938
Brugia malayi Nuclear hormone receptor-like 1 0.0154 0.1378 0.2146
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0576 0.1364
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0087 0.0645 0.1004
Schistosoma mansoni neuropeptide receptor 0.0053 0.0265 0.0367
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.0265 0.0265
Echinococcus granulosus ecdysone induced protein 78C 0.0291 0.2897 0.2897
Brugia malayi Melatonin receptor type 1A 0.0053 0.0265 0.0413
Echinococcus multilocularis peroxidasin 0.0081 0.0576 0.0576
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Schistosoma mansoni steroid hormone receptor ad4bp 0.0291 0.2897 0.4016
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0053 0.026 0.0405
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0087 0.0645 0.1527
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0056 0.0296 0.041
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.0265 0.0367
Echinococcus granulosus glycine receptor subunit beta 0.0087 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0154 0.1378 0.3264
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Schistosoma mansoni adenoreceptor 0.0053 0.0265 0.0367
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0035 0.0061 0.0061
Brugia malayi glutaminase DH11.1 0.0269 0.266 0.4144
Schistosoma mansoni nuclear receptor 0.0137 0.1195 0.1657
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0265 0.0265
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0035 0.0068 0.0285
Echinococcus granulosus pyruvate kinase 0.0032 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0035 0.0061 0.0095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0035 0.0061 0.0095
Brugia malayi neuropeptide F receptor 0.0053 0.0265 0.0413
Schistosoma mansoni glutaminase 0.0269 0.266 0.3688
Brugia malayi DnaJ domain containing protein 0.006 0.0345 0.0537
Brugia malayi Dopamine receptor protein 2 0.0053 0.0265 0.0413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0035 0.0061 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0137 0.1195 0.1657
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0291 0.2897 0.4016
Loa Loa (eye worm) PDE1B protein 0.0035 0.0068 0.0162
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0056 0.0296 0.0296
Brugia malayi Serotonin receptor 0.0053 0.0265 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni biogenic amine receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0291 0.2899 0.4018
Schistosoma mansoni thyroid hormone receptor 0.068 0.7214 1
Brugia malayi Dopamine receptor 0.0053 0.0265 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0291 0.2897 0.4513
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus 0.0035 0.0061 0.0182
Plasmodium falciparum transporter, putative 0.0056 0.0296 0.2202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Brugia malayi G protein-coupled receptor 0.0053 0.0265 0.0413
Brugia malayi follicle stimulating hormone receptor 0.0053 0.0265 0.0413
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0461
Loa Loa (eye worm) hypothetical protein 0.0048 0.0212 0.0501
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni retinoic acid receptor RXR 0.0291 0.2897 0.4016
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Schistosoma mansoni amine GPCR 0.0053 0.0265 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0291 0.2897 0.6863
Echinococcus granulosus FTZ F1 alpha 0.0291 0.2897 0.2897
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0296 0.041
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.026 0.036
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0055 0.0055
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0345 0.052
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Loa Loa (eye worm) nuclear hormone receptor 0.0137 0.1195 0.2832
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0279 0.2769 0.7424
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.0051 0.0135
Brugia malayi AKH receptor 0.0053 0.0265 0.0413
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0171 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0035 0.0061 0.0061
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0576 0.1731
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0171 0.1568 0.1568
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.0265 0.0265
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0265 0.0265
Onchocerca volvulus 0.0056 0.0296 0.0889
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0265 0.0265
Brugia malayi Serotonin receptor 0.0609 0.6419 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0137 0.1195 0.1195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.0051 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Loa Loa (eye worm) hypothetical protein 0.0291 0.2899 0.6866
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus granulosus neuropeptide s receptor 0.0053 0.0265 0.0265
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0139 0.1221 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0087 0.0645 0.1004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0137 0.1195 0.1195
Echinococcus multilocularis allatostatin A receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0056 0.0296 0.071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Onchocerca volvulus 0.0137 0.1195 0.3593
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.0265 0.0413
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0162
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0056 0.0296 0.041
Brugia malayi Peroxidasin 0.0081 0.0576 0.0897
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0139 0.1214 0.1683
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0291 0.2897 0.6863
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0212 0.033
Brugia malayi Protein kinase domain containing protein 0.0029 0.000000018783 0.00000002926
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.0265 0.0628
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0061 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0068 0.0285
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0081 0.0576 0.1364
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0087 0.0645 0.1527
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Onchocerca volvulus 0.0056 0.0296 0.0889
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.0051 0.0135
Echinococcus multilocularis sodium and chloride dependent glycine 0.0056 0.0296 0.0296
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0055 0.0077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Plasmodium falciparum phosphodiesterase delta, putative 0.0035 0.0068 0.0285
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0315
Onchocerca volvulus Bile acid receptor homolog 0.0291 0.2897 0.8707
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis nuclear receptor nhr 48 0.0137 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.0265 0.0265
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.1335 0.1335
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0913
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0291 0.2897 0.4513
Echinococcus multilocularis pyruvate kinase 0.0032 0.0034 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0053 0.0265 0.0796
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0053 0.026 0.0405
Schistosoma mansoni sodium-dependent amino acid transporter 0.0056 0.0296 0.041
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0035 0.0068 0.0068
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0035 0.0068 0.0068
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0035 0.0068 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0291 0.2897 0.6863
Loa Loa (eye worm) hypothetical protein 0.033 0.3327 0.7882
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0034 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0291 0.2897 0.4513
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Brugia malayi RE15519p 0.0053 0.0265 0.0413
Leishmania major hypothetical protein, conserved 0.0035 0.0068 0.0285
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0137 0.1195 0.1657
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.0265 0.0413
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.0265 0.0367
Loa Loa (eye worm) DR-78 0.0137 0.1195 0.2832
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0291 0.2897 0.6863
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.039 0.054
Brugia malayi hypothetical protein 0.0134 0.1162 0.181
Loa Loa (eye worm) hypothetical protein 0.0291 0.2897 0.6863
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0291 0.2897 0.4016
Brugia malayi nuclear hormone receptor family member odr-7 0.0137 0.1195 0.1862
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0087 0.0645 0.0645
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0154 0.1378 0.1378
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.0265 0.0628
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Onchocerca volvulus 0.0053 0.0265 0.0796
Plasmodium falciparum amino acid transporter, putative 0.0056 0.0296 0.2202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0291 0.2897 0.4016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.0265 0.0367
Echinococcus granulosus Nuclear hormone receptor HR96 0.0137 0.1195 0.1195
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Loa Loa (eye worm) hypothetical protein 0.02 0.1894 0.4487
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0285
Brugia malayi hypothetical protein 0.0137 0.1195 0.1862
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.0265 0.0413
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.0265 0.0367
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0291 0.2897 0.2897
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus granulosus peroxidasin 0.0081 0.0576 0.0576
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.000000018783 0.000000026037
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.0616
Giardia lamblia Fructose-bisphosphate aldolase 0.0571 0.6007 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Brugia malayi Cation transporter family protein 0.0087 0.0645 0.1004
Echinococcus granulosus serotonin receptor 0.0053 0.0265 0.0265
Brugia malayi hypothetical protein 0.0035 0.0061 0.0095
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0137 0.1195 0.2832
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Schistosoma mansoni pyruvate kinase 0.0032 0.0034 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0087 0.0645 0.1527
Schistosoma mansoni pyruvate kinase 0.0032 0.0034 0.0048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0035 0.0068 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.0265 0.0367
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Onchocerca volvulus 0.0291 0.2897 0.8707
Onchocerca volvulus 0.0087 0.0645 0.1938
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.0051 0.012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.6007 1
Echinococcus multilocularis fmrfamide receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0035 0.0068 0.0057
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0087 0.0645 0.0645
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.039 0.054
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.0265 0.0367
Brugia malayi hypothetical protein 0.0041 0.0133 0.0207
Echinococcus multilocularis g protein coupled receptor 0.0053 0.0265 0.0265
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0087 0.0645 0.1527
Brugia malayi Nuclear hormone receptor E75 0.0137 0.1195 0.1862
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0291 0.2899 0.2899
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0035 0.0068 0.0285
Onchocerca volvulus 0.033 0.3327 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.039 0.0965
Loa Loa (eye worm) hypothetical protein 0.0053 0.0265 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.0265 0.0265
Plasmodium falciparum phosphodiesterase gamma, putative 0.0035 0.0068 0.0285
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.0265 0.0367
Echinococcus granulosus g-protein coupled receptor 0.0053 0.0265 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0087 0.0645 0.0645
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0576 0.0897
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0087 0.0645 0.0645
Leishmania major hypothetical protein, conserved 0.0034 0.0051 0.0135
Schistosoma mansoni dihydrofolate reductase 0.0365 0.3717 0.5153
Echinococcus granulosus glycine receptor subunit alpha 1 0.0087 0.0645 0.0645
Schistosoma mansoni nAChR subunit 0.0087 0.0645 0.0894
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0323 0.0765
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.0645 0.0645
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0056 0.0296 0.0701
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0087 0.0645 0.1004
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.0265 0.0265
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Entamoeba histolytica hypothetical protein 0.0053 0.026 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0061 0.0144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.0265 0.0265
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0291 0.2899 0.4796
Giardia lamblia hypothetical protein 0.0035 0.0068 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0932 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.0265 0.0265
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0035 0.0068 0.0285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0035 0.0068 0.0057
Mycobacterium ulcerans glutaminase 0.0269 0.266 0.7129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0137 0.1195 0.1195

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.25 nM Quantitative effect of the compound on the [14C]-guanidinium accumulation in NG 108-15 cells (mouse neuroblastoma and rat glioma hybrid cells) ChEMBL. 10229626
Intrinsic activity (binding) Intrinsic activity of the compound towards 5-hydroxytryptamine 3 receptor was determined by BenzoldJarisch reflex (peripheral assay); NA means data not available ChEMBL. 12217367
Intrinsic activity (functional) Intrinsic activity of the compound towards CNS 5-hydroxytryptamine 3 receptor was determined; PA : Partial agonist ChEMBL. 12217367
Intrinsic activity (functional) 0 Intrinsic activity of the compound towards CNS 5-hydroxytryptamine 3 receptor was determined; PA : Partial agonist ChEMBL. 12217367
Intrinsic activity (binding) 0 Intrinsic activity of the compound towards 5-hydroxytryptamine 3 receptor was determined by BenzoldJarisch reflex (peripheral assay); NA means data not available ChEMBL. 12217367
Intrinsic efficacy (functional) Intrinsic efficacy of the compound against 5-hydroxytryptamine 3 receptor; PA means partial agonist ChEMBL. 10229626
Intrinsic efficacy (functional) 0 Intrinsic efficacy of the compound against 5-hydroxytryptamine 3 receptor; PA means partial agonist ChEMBL. 10229626
Ki (functional) = -10.01 Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonist ChEMBL. 9622544
Ki (binding) = -9.64 Binding affinity at 5-hydroxytryptamine 3 receptor in rat cortical membrane by [3H]-graniestron displacement. ChEMBL. 9513601
Ki (binding) = 0.23 nM Ability to displace [3H]-granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane ChEMBL. 9513601
Ki (binding) = 0.23 nM Inhibition of [3H]-granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissue ChEMBL. 10229626
Ki (binding) = 0.23 nM Binding affinity towards 5-hydroxytryptamine 3 receptor ChEMBL. 12217367
Ki (binding) = 0.23 nM Displacement of [3H]-granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membrane ChEMBL. 15887964
Ki (binding) = 0.23 nM Ability to displace [3H]-granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane ChEMBL. 9513601
Ki (binding) = 0.23 nM Inhibition of [3H]-granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissue ChEMBL. 10229626
Ki (binding) = 0.23 nM Binding affinity towards 5-hydroxytryptamine 3 receptor ChEMBL. 12217367
Ki (binding) = 0.23 nM Displacement of [3H]-granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membrane ChEMBL. 15887964
Ki (binding) = 2800 nM Ability to displace [3H]- -OH-DPAT bound to 5-hydroxytryptamine 1A receptor in rat hippocampus ChEMBL. 9513601
Ki (binding) = 2800 nM Ability to displace [3H]- -OH-DPAT bound to 5-hydroxytryptamine 1A receptor in rat hippocampus ChEMBL. 9513601
Ki (binding) = 3000 nM Ability to displace [3H]-ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex ChEMBL. 9513601
Ki (binding) = 3000 nM Ability to displace [3H]-ketanserin bound to 5-hydroxytryptamine 2A receptor in rat pre-frontal cortex ChEMBL. 9513601
Ki (binding) > 4000 nM Ability to displace [3H]-5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum ChEMBL. 9513601
Ki (binding) > 4000 nM Ability to displace [3H]-5-HT bound to 5-hydroxytryptamine 1B receptor in rat striatum ChEMBL. 9513601
Ki (binding) = 4400 nM Ability to displace [3H]-Mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortex ChEMBL. 9513601
Ki (binding) = 4400 nM Ability to displace [3H]-Mesulergine bound to 5-hydroxytryptamine 2C receptor in rat cortex ChEMBL. 9513601
Ki (binding) = 12000 nM Ability to displace [3H]-paroxetine bound to Serotonin transporter receptor in rat forebrain ChEMBL. 9513601
Ki (binding) = 12000 nM Ability to displace [3H]-paroxetine bound to Serotonin transporter receptor in rat forebrain ChEMBL. 9513601
Log Ki (binding) = 9.64 Binding affinity at 5-hydroxytryptamine 3 receptor in rat cortical membrane by [3H]-graniestron displacement. ChEMBL. 9513601
Log Ki (functional) = 10.01 Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonist ChEMBL. 9622544
Selectivity (binding) = 12000 Selectivity is the ratio of binding affinity against 5-HT1A receptor to that of 5-HT3 receptor ChEMBL. 9513601
Selectivity (binding) = 13000 Selectivity is the ratio of binding affinity against 5-HT2A receptor to that of 5-HT3 receptor ChEMBL. 9513601
Selectivity (binding) > 17000 Selectivity is the ratio of binding affinity against 5-HT1B receptor to that of 5-HT3 receptor ChEMBL. 9513601
Selectivity (binding) = 19000 Selectivity is the ratio of binding affinity against 5-HT2C receptor to that of 5-HT3 receptor ChEMBL. 9513601
Selectivity (binding) = 52000 Selectivity is the ratio of binding affinity against 5-HT transporter to that of 5-HT3 receptor ChEMBL. 9513601

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.