Detailed information for compound 599023

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.77 | Formula: C16H15ClN4
  • H donors: 2 H acceptors: 0 LogP: 3.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NN=Cc1cc2ccccc2c2c1cccc2.Cl
  • InChi: 1S/C16H14N4.ClH/c17-16(18)20-19-10-12-9-11-5-1-2-6-13(11)15-8-4-3-7-14(12)15;/h1-10H,(H4,17,18,20);1H
  • InChiKey: RPBHLYONUNLEHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0018 0.0016 0.0027
Schistosoma mansoni glutaminase 0.0552 0.3121 0.5247
Schistosoma mansoni netrin receptor unc5 0.0064 0.028 0.0471
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0093 0.0086
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0768 0.0762
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.002 0.0017
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0093 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0093 0.0157
Toxoplasma gondii PAN domain-containing protein 0.0041 0.0151 0.0371
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0329 0.1921
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0498 0.0492
Onchocerca volvulus 0.009 0.0435 0.4386
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Mycobacterium ulcerans hypothetical protein 0.0072 0.0327 0.1041
Loa Loa (eye worm) hypothetical protein 0.0047 0.0181 0.0227
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0042 0.0153 0.4155
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.002 0.0341
Schistosoma mansoni hypothetical protein 0.1038 0.5947 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0073 0.0425
Onchocerca volvulus Netrin receptor homolog 0.0064 0.028 0.2744
Leishmania major cathepsin L-like protease 0.0019 0.002 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Mycobacterium ulcerans glutaminase 0.0552 0.3121 1
Toxoplasma gondii PAN domain-containing protein 0.0041 0.0151 0.0371
Onchocerca volvulus 0.003 0.0087 0.071
Leishmania major cathepsin L-like protease 0.0072 0.0329 0.1921
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0093 0.0086
Brugia malayi Bromodomain containing protein 0.0042 0.0156 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0764 0.4457
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0042 0.0153 0.0481
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0054 0.0315
Leishmania major cathepsin L-like protease 0.0072 0.0329 0.1921
Schistosoma mansoni hypothetical protein 0.0074 0.034 0.0572
Toxoplasma gondii PAN domain-containing protein 0.0643 0.3647 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0138 0.2521
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Schistosoma mansoni egf-like domain protein 0.0029 0.0079 0.0133
Loa Loa (eye worm) hypothetical protein 0.003 0.0087 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0164 0.0956
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.0162 0.0623
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0093 0.0111
Brugia malayi beta-lactamase family protein 0.0072 0.0327 0.0421
Onchocerca volvulus 0.0041 0.0151 0.1379
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0276 0.0349
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0093 0.0114
Onchocerca volvulus 0.0041 0.0151 0.1379
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0172 0.0213
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0276 0.0349
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.002 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0093 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.002 0.0025
Mycobacterium ulcerans polyketide synthase 0.0052 0.0212 0.067
Toxoplasma gondii ABC1 family protein 0.0072 0.0327 0.0858
Loa Loa (eye worm) hypothetical protein 0.135 0.7763 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.005 0.0203 0.0783
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0327 0.1909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0327 0.0416
Echinococcus granulosus importin subunit beta 1 0.0028 0.0073 0.0085
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.1222 0.1569
Echinococcus granulosus cathepsin l1 0.0019 0.002 0.0017
Echinococcus multilocularis protein dispatched 1 0.005 0.0198 0.0192
Echinococcus granulosus GPCR family 2 0.0113 0.0565 0.0719
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0093 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.1159 0.6761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Onchocerca volvulus 0.0072 0.0327 0.3246
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0327 0.1268
Loa Loa (eye worm) intermediate filament protein 0.003 0.0087 0.0106
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0013 0.001
Toxoplasma gondii hypothetical protein 0.005 0.0201 0.051
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0327 0.1046
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0032
Toxoplasma gondii cathepsin CPL 0.0019 0.002 0.0011
Onchocerca volvulus 0.0041 0.0151 0.1379
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0093 0.0119
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0281 0.0275
Echinococcus multilocularis musashi 0.003 0.0087 0.0081
Schistosoma mansoni hypothetical protein 0.0113 0.0565 0.095
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0016 0.0005 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0093 0.0111
Onchocerca volvulus 0.0041 0.0151 0.1379
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0003 0.0002
Leishmania major importin beta-1 subunit, putative 0.0023 0.0042 0.0246
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0022
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0768 0.0988
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Schistosoma mansoni patched 1 0.0043 0.0163 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0093 0.0114
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Brugia malayi MH2 domain containing protein 0.0018 0.0013 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0093 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.002 0.0061
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.1146
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0093 0.0119
Entamoeba histolytica hypothetical protein 0.0074 0.034 0.6714
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Echinococcus granulosus Smad4 0.0018 0.0013 0.0008
Echinococcus granulosus muscleblind protein 0.135 0.7763 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0329 0.1921
Schistosoma mansoni ap endonuclease 0.0018 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0016 0.0014
Entamoeba histolytica hypothetical protein 0.0074 0.034 0.6714
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0093 0.0772
Toxoplasma gondii microneme protein MIC17B 0.0041 0.0151 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0093 0.0114
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0022
Schistosoma mansoni coup transcription factor 0.0031 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0093 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0113 0.0565 0.0719
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Loa Loa (eye worm) hypothetical protein 0.0045 0.017 0.0213
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0064 0.028 0.0354
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0093 0.0119
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1551 0.1546
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0042 0.0132
Leishmania major hypothetical protein, conserved 0.0215 0.1159 0.6761
Toxoplasma gondii type I fatty acid synthase, putative 0.0037 0.0125 0.03
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0172 0.043
Onchocerca volvulus 0.0041 0.0151 0.1379
Brugia malayi nuclear receptor RXR 0.0017 0.0007 0.0008
Entamoeba histolytica hypothetical protein 0.0023 0.0042 0.0542
Brugia malayi Smad1 0.0018 0.0013 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0093 0.0119
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.073 0.0933
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0016 0.0058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0016 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0279 0.0351
Brugia malayi PHD-finger family protein 0.0029 0.0077 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Onchocerca volvulus 0.0041 0.0151 0.1379
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.001 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0073 0.0157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0276 0.0464
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.002 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0052 0.0212 0.581
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0093 0.0114
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0751 0.0959
Brugia malayi MH1 domain containing protein 0.0018 0.0013 0.0015
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0508 0.0853
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0164 0.0956
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0054 0.0047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0113 0.0565 0.0726
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0293 0.1709
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1551 0.2609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1551 0.2609
Brugia malayi Calcitonin receptor-like protein seb-1 0.0356 0.1979 0.2549
Echinococcus multilocularis smad 0.0018 0.0013 0.0006
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0029 0.0079 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0279 0.0885
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0327 0.1268
Brugia malayi nuclear receptor NHR-88 0.0031 0.0093 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0219 0.128
Schistosoma mansoni hypothetical protein 0.0113 0.0565 0.095
Brugia malayi RNA, U transporter 1 0.008 0.0373 0.0479
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0064 0.028 0.0352
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.1715 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.1715 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0327 0.1909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0093 0.0086
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0013 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.002 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0093 0.0119
Echinococcus multilocularis geminin 0.1038 0.5947 0.5945
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0764 0.4457
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0043 0.0036
Schistosoma mansoni ran 0.0021 0.003 0.005
Brugia malayi N-terminal motif family protein 0.0182 0.0967 0.1244
Mycobacterium tuberculosis Polyketide synthase Pks2 0.005 0.0203 0.0783
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0163 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0923 0.2955
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0327 0.1268
Echinococcus multilocularis GPCR, family 2 0.0113 0.0565 0.0558
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0054 0.0164
Echinococcus granulosus tar DNA binding protein 0.0063 0.0276 0.0347
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0007 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0215 0.1159 0.6761
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0026 0.0063 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Brugia malayi RNA binding protein 0.0063 0.0276 0.0354
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0327 0.1268
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.0231 0.0591
Echinococcus multilocularis Tolloid protein 1 0.0029 0.0079 0.0073
Schistosoma mansoni hypothetical protein 0.0042 0.0154 0.0258
Schistosoma mansoni bromodomain containing protein 0.0067 0.0302 0.0509
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0034 0.011 0.2941
Echinococcus multilocularis laminin 0.0029 0.0079 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0327 0.0421
Onchocerca volvulus Arrow homolog 0.0029 0.0079 0.0625
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0327 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.2576 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0327 0.1046
Echinococcus granulosus lamin dm0 0.003 0.0087 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0019
Mycobacterium tuberculosis Conserved protein 0.0072 0.0327 0.1268
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.0231 0.0891
Leishmania major mitochondrial DNA polymerase beta 0.031 0.1715 1
Schistosoma mansoni ran 0.0021 0.003 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Echinococcus granulosus smad 0.0018 0.0013 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0093 0.0157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.002 0.0013
Trichomonas vaginalis ran, putative 0.0021 0.003 0.0093
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0327 0.1909
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0175
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0203
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0016 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.002 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0016 0.0094
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.024 0.1397
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0093 0.0119
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0498 0.0641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0093 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.002 0.0118
Onchocerca volvulus 0.0041 0.0151 0.1379
Leishmania major cathepsin L-like protease 0.0019 0.002 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0751 0.0744
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0082 0.0313
Leishmania major hypothetical protein, conserved 0.0072 0.0327 0.1909
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0093 0.0119
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0163 0.0203
Brugia malayi hypothetical protein 0.05 0.2816 0.3627
Mycobacterium tuberculosis Conserved protein 0.0072 0.0327 0.1268
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Schistosoma mansoni hypothetical protein 0.0042 0.0154 0.0258
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0768 0.1291
Brugia malayi hypothetical protein 0.0074 0.034 0.0437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Onchocerca volvulus 0.0041 0.0151 0.1379
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0016 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0279 0.0724
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Echinococcus granulosus expressed conserved protein 0.0095 0.0463 0.0588
Brugia malayi Protein kinase domain containing protein 0.0064 0.0284 0.0364
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0098 0.0482 0.062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0327 0.1268
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0861 0.3338
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0212 0.067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1551 0.1992
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.003 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0327 0.1046
Mycobacterium ulcerans polyketide synthase Pks13 0.0078 0.0361 0.1149
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0327 0.1268
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.034 0.0572
Onchocerca volvulus 0.0041 0.0151 0.1379
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.142 0.1823
Brugia malayi TAR-binding protein 0.0063 0.0276 0.0354
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0007 0.0012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0093 0.0119
Leishmania major cysteine peptidase A (CPA) 0.0019 0.002 0.0118
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0212 0.067
Leishmania major cathepsin L-like protease 0.0019 0.002 0.0118
Toxoplasma gondii microneme protein MIC17C 0.0041 0.0151 0.0371
Echinococcus multilocularis muscleblind protein 0.135 0.7763 0.7761
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0121 0.0147
Brugia malayi ecdysteroid receptor 0.0031 0.0093 0.0119
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0276 0.0269
Echinococcus multilocularis lamin dm0 0.003 0.0087 0.0081
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0013 0.0008
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1375 0.177
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.002 0.0019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0052 0.0212 0.0819
Echinococcus multilocularis snurportin 1 0.0299 0.1648 0.1642
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0052 0.0212 0.0819
Plasmodium falciparum importin beta, putative 0.0028 0.0073 0.468
Schistosoma mansoni hypothetical protein 0.0243 0.1325 0.2227
Onchocerca volvulus 0.003 0.0087 0.071
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0054 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Echinococcus multilocularis expressed conserved protein 0.0095 0.0463 0.0456
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.0132
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1375 0.1766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Entamoeba histolytica cysteine protease, putative 0.0019 0.002 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0016 0.0048
Echinococcus granulosus survival motor neuron protein 1 0.05 0.2816 0.3622
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.002 0.0341
Brugia malayi Importin beta-1 subunit 0.0028 0.0073 0.0093
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0029 0.0079 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0215 0.1159 0.6761
Toxoplasma gondii microneme protein MIC4 0.0041 0.0151 0.0371
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0042 0.0246
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0064 0.028 0.0273
Mycobacterium leprae Polyketide synthase Pks13 0.0078 0.0361 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0093 0.0157
Loa Loa (eye worm) ctsf protein 0.0019 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0093 0.0114
Brugia malayi Bromodomain containing protein 0.0079 0.0371 0.0477
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0093 0.0772
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0212 0.067
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0327 0.0413
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0054 0.0206
Loa Loa (eye worm) glutaminase 0.0552 0.3121 0.4016
Schistosoma mansoni smad1 5 8 and 0.0018 0.0013 0.0022
Toxoplasma gondii subtilisin SUB12 0.0041 0.0151 0.0371
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.002 0.0017
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0052 0.0212 0.581
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0329 0.1921
Loa Loa (eye worm) hypothetical protein 0.0053 0.0219 0.0276
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0016 0.0003 0.0007
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0064 0.028 0.0471
Brugia malayi beta-lactamase family protein 0.0072 0.0327 0.0421
Onchocerca volvulus 0.0148 0.0768 0.7901
Loa Loa (eye worm) acetyltransferase 0.0147 0.0768 0.0983
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.001 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0327 0.0551
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0055 0.0231 0.0891
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.0231 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Echinococcus multilocularis Smad4 0.0018 0.0013 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0093 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0356 0.1979 0.2549
Mycobacterium tuberculosis Conserved protein 0.0025 0.0054 0.0206
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0016 0.0009
Schistosoma mansoni lamin 0.003 0.0087 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0093 0.0119
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.0231 0.073
Schistosoma mansoni importin beta-1 0.0028 0.0073 0.0123
Echinococcus multilocularis microtubule associated protein 2 0.0721 0.4101 0.4097
Schistosoma mansoni intermediate filament proteins 0.003 0.0087 0.0147
Toxoplasma gondii hypothetical protein 0.0041 0.0151 0.0371
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.028 0.0359
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0093 0.0157
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0093 0.0111
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0054 0.017
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.0162 0.4398
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0279 0.0885
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0042 0.0153 0.0481
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0029 0.0079 0.0133
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0093 0.0157
Brugia malayi intermediate filament protein 0.003 0.0087 0.0111
Mycobacterium ulcerans hypothetical protein 0.0025 0.0054 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0016 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Loa Loa (eye worm) PAN domain-containing protein 0.0041 0.0151 0.0188
Schistosoma mansoni hypothetical protein 0.0113 0.0565 0.095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.034 0.0429
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.142 0.1823
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.001 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0087 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.1551 0.1993
Echinococcus granulosus snurportin 1 0.0299 0.1648 0.2116
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0032 0.0121
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Onchocerca volvulus 0.0041 0.0151 0.1379
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0121 0.0114
Loa Loa (eye worm) PAN domain-containing protein 0.0041 0.0151 0.0188
Leishmania major hypothetical protein, conserved 0.0016 0.0001 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0093 0.0111
Echinococcus multilocularis fibrillin 1 0.0029 0.0079 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Schistosoma mansoni hypothetical protein 0.0113 0.0565 0.095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.034 0.0333
Schistosoma mansoni microtubule-associated protein tau 0.0721 0.4101 0.6896
Brugia malayi follicle stimulating hormone receptor 0.0226 0.1222 0.1573
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0093 0.0086
Entamoeba histolytica hypothetical protein 0.0074 0.034 0.6714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.001 0.0017
Echinococcus granulosus intermediate filament protein 0.003 0.0087 0.0104
Brugia malayi MH2 domain containing protein 0.026 0.142 0.1828
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0055 0.0231 0.6337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0048 0.0192 0.0742
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0087 0.0106
Echinococcus granulosus geminin 0.1038 0.5947 0.7659
Toxoplasma gondii microneme protein MIC17A 0.0041 0.0151 0.0371
Loa Loa (eye worm) PAN domain-containing protein 0.0041 0.0151 0.0188
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0093 0.0157
Leishmania major GTP-binding protein, putative 0.0021 0.003 0.0175
Mycobacterium ulcerans thioesterase 0.0043 0.0162 0.0509
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0093 0.0157
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0087
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0013 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0016 0.0094
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0029 0.0079 0.0096
Echinococcus granulosus Ankyrin 0.0064 0.028 0.0352
Onchocerca volvulus 0.0041 0.0151 0.1379
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.002 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0093 0.0157
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0172 0.043
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.0014 0.005
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0329 0.1921
Echinococcus granulosus netrin receptor unc 5 0.0064 0.028 0.0352
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0013 0.0006
Brugia malayi beta-lactamase 0.0072 0.0327 0.0421
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0327 0.9056
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0127 0.0489
Brugia malayi glutaminase DH11.1 0.0552 0.3121 0.4019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.001 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Brugia malayi Latrophilin receptor protein 2 0.0113 0.0565 0.0726
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0356 0.1979 0.2545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1551 0.1992
Loa Loa (eye worm) beta-lactamase 0.0072 0.0327 0.0416
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0054 0.0315
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0157 0.0605
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0016 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Onchocerca volvulus 0.0102 0.0503 0.51
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0043 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0093 0.0157
Entamoeba histolytica hypothetical protein 0.0074 0.034 0.6714
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0029 0.0079 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.002 0.0061
Toxoplasma gondii microneme protein, putative 0.0041 0.0151 0.0371
Loa Loa (eye worm) hypothetical protein 0.0064 0.028 0.0354
Loa Loa (eye worm) glutaminase 2 0.0552 0.3121 0.4016
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0073 0.0425
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0164 0.0956
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0093 0.0119
Loa Loa (eye worm) PAN domain-containing protein 0.0041 0.0151 0.0188
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0007 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0172 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0871 0.279
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.0192 0.0241
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.002 0.0019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0113 0.0565 0.0558
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0967 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0279 0.0885
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0073 0.0066
Loa Loa (eye worm) hypothetical protein 0.0101 0.0498 0.0636
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0281 0.0354
Loa Loa (eye worm) fatty acid synthase 0.0051 0.0208 0.0261
Schistosoma mansoni lamin 0.003 0.0087 0.0147
Mycobacterium tuberculosis Conserved protein 0.0072 0.0327 0.1268
Onchocerca volvulus 0.0048 0.0192 0.1816
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0164 0.0956
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0034 0.0106 0.0247
Echinococcus multilocularis cysteine protease 0.0019 0.002 0.0013
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0871 0.8993
Brugia malayi Muscleblind-like protein 0.135 0.7763 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0138 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.002 0.0034
Mycobacterium ulcerans hypothetical protein 0.0163 0.0861 0.2751
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.003 0.2117
Loa Loa (eye worm) hypothetical protein 0.0243 0.1325 0.1701
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0279 0.1627
Mycobacterium leprae Probable lipase LipE 0.0072 0.0327 0.9056
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0005 0.0005
Onchocerca volvulus Fatty acid synthase homolog 0.0094 0.0454 0.4584
Loa Loa (eye worm) hypothetical protein 0.0064 0.028 0.0354
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0052 0.0212 0.0272
Toxoplasma gondii calcium binding egf domain-containing protein 0.0029 0.0079 0.0174
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0276 0.0464
Loa Loa (eye worm) RNA binding protein 0.0063 0.0276 0.0349
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0007 0.0012
Echinococcus granulosus laminin 0.0029 0.0079 0.0093
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0016 0.1097
Loa Loa (eye worm) hypothetical protein 0.0182 0.0967 0.1239
Schistosoma mansoni hypothetical protein 0.0042 0.0154 0.0258
Onchocerca volvulus 0.0031 0.0093 0.0772
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0054 0.0164
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0113 0.0565 0.0558
Schistosoma mansoni hypothetical protein 0.0299 0.1648 0.2771
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0034 0.011 0.0342
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1551 0.1546
Brugia malayi Uncoordinated protein 44 0.0064 0.028 0.0359
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.003 0.0447
Schistosoma mansoni hypothetical protein 0.0021 0.0031 0.0053
Mycobacterium ulcerans hypothetical protein 0.0025 0.0054 0.0164
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0078 0.0361 0.1398
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0279 0.0469
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0102 0.0503 0.0647
Loa Loa (eye worm) hypothetical protein 0.0113 0.0565 0.0722
Loa Loa (eye worm) hypothetical protein 0.0148 0.0768 0.0983
Mycobacterium ulcerans fatty acid synthase Fas 0.0016 0.0005 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0643 0.3647 1
Echinococcus multilocularis protein patched 0.0043 0.0163 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0276 0.0464
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0327 0.1041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0102
Onchocerca volvulus 0.0072 0.0327 0.3246
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0279 0.0469
Brugia malayi nuclear hormone receptor 0.0031 0.0093 0.0119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0764 0.4457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Toxoplasma gondii PAN domain-containing protein 0.0041 0.0151 0.0371
Brugia malayi hypothetical protein 0.0017 0.0007 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0031 0.0034
Mycobacterium ulcerans polyketide synthase Pks9 0.0034 0.011 0.0342
Plasmodium vivax importin-beta 2, putative 0.0028 0.0073 0.1828
Brugia malayi Fibulin-1 precursor 0.0029 0.0079 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0093 0.0119
Mycobacterium ulcerans lipase LipD 0.0072 0.0327 0.1041
Toxoplasma gondii PAN/Apple domain-containing protein 0.0041 0.0151 0.0371
Schistosoma mansoni hypothetical protein 0.0064 0.028 0.0471
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.002 0.0086
Echinococcus multilocularis zinc finger protein 0.0023 0.0046 0.0039
Loa Loa (eye worm) PAN domain-containing protein 0.0041 0.0151 0.0188
Toxoplasma gondii PAN domain-containing protein 0.0041 0.0151 0.0371
Onchocerca volvulus 0.0072 0.0327 0.3246
Echinococcus granulosus lamin 0.003 0.0087 0.0104
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0016 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0007 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.001 0.0004
Echinococcus granulosus microtubule associated protein 2 0.0721 0.4101 0.5279
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0093 0.0111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0113 0.0565 0.0719
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0279 0.1079
Schistosoma mansoni survival motor neuron protein 0.0102 0.0503 0.0845
Schistosoma mansoni Smad4 0.0018 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0042 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0327 0.0321
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0172 0.0549
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.003 0.003
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.1715 1
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0049 0.0056
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0172 0.5015
Leishmania major cathepsin L-like protease 0.0019 0.002 0.0118
Schistosoma mansoni ankyrin 23/unc44 0.0064 0.028 0.0471
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0212 0.0819
Brugia malayi Calcium binding EGF domain containing protein 0.0029 0.0079 0.0101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0093 0.0772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.002 0.0061
Toxoplasma gondii hypothetical protein 0.0041 0.0151 0.0371
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0276 0.0354
Loa Loa (eye worm) cysteine protease 0.0019 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0327 0.0551
Echinococcus multilocularis cysteine protease 0.0019 0.002 0.0013
Echinococcus multilocularis netrin receptor unc 5 0.0064 0.028 0.0273
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Schistosoma mansoni smad 0.0018 0.0013 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0093 0.0119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0016 0.0094
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0923 0.2955
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1551 0.2609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.1551 0.1998
Mycobacterium ulcerans beta-lactamase 0.0072 0.0327 0.1041
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0163 0.0201
Echinococcus granulosus death domain containing protein 0.0064 0.028 0.0352
Schistosoma mansoni hypothetical protein 0.0042 0.0154 0.0258
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1375 0.4404
Brugia malayi hypothetical protein 0.0148 0.0768 0.0988
Loa Loa (eye worm) hypothetical protein 0.0356 0.1979 0.2545
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0113 0.0565 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0093 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0093 0.0114
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0093 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0192 0.0246
Brugia malayi latrophilin 2 splice variant baaae 0.0243 0.1325 0.1705
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0043 0.0046
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0078 0.0361 0.1398
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0327 0.1268
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0035 0.0038
Echinococcus multilocularis muscleblind protein 1 0.135 0.7763 0.7761
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0093 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0093 0.0114
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0054 0.0315
Loa Loa (eye worm) hypothetical protein 0.05 0.2816 0.3623
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0327 0.1046
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0498 0.0634
Mycobacterium leprae Probable polyketide synthase Pks1 0.0055 0.0231 0.6337
Brugia malayi PAN domain containing protein 0.0041 0.0151 0.0193
Echinococcus multilocularis lamin 0.003 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0016 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.001 0.0004
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.002 0.0034
Brugia malayi steroid hormone receptor 0.0031 0.0093 0.0119
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0055 0.0231 0.6337
Brugia malayi Cathepsin L-like precursor 0.0019 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0114
Toxoplasma gondii calcium binding egf domain-containing protein 0.0029 0.0079 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0093 0.0119
Loa Loa (eye worm) hypothetical protein 0.0087 0.0417 0.0531
Schistosoma mansoni methyltransferase-related 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.1038 0.5947 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0093 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Brugia malayi CHE-14 protein 0.0043 0.0163 0.0208
Loa Loa (eye worm) fibroinase 0.0019 0.002 0.0019
Echinococcus multilocularis Ankyrin 0.0064 0.028 0.0273
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.003 0.0038
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0279 0.0272
Loa Loa (eye worm) hypothetical protein 0.0072 0.0327 0.0416
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0096
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0327 0.1041
Loa Loa (eye worm) Smad1 0.0018 0.0013 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0327 0.1046
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0093 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0276 0.0464
Mycobacterium ulcerans polyketide synthase 0.0055 0.0231 0.073
Plasmodium vivax vivapain-2 0.0019 0.002 0.0133
Schistosoma mansoni zinc finger protein 0.0023 0.0046 0.0077
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0212 0.067
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0093 0.0157
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0013 0.0006
Trichomonas vaginalis esterase, putative 0.0072 0.0327 0.1046
Brugia malayi hypothetical protein 0.0017 0.0007 0.0008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1648 0.2118
Brugia malayi MH2 domain containing protein 0.0018 0.0013 0.0015
Entamoeba histolytica Ran family GTPase 0.0021 0.003 0.0289
Trichomonas vaginalis glutaminase, putative 0.0552 0.3121 1
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0041 0.0151 0.0371
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0093 0.0111
Echinococcus granulosus Tolloid protein 1 0.0029 0.0079 0.0093
Plasmodium vivax vivapain-2 0.0019 0.002 0.0133
Brugia malayi MH1 domain containing protein 0.0018 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0135 0.0168
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0163 0.0201
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0498 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0325 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0163 0.0518
Loa Loa (eye worm) hypothetical protein 0.135 0.7763 1
Echinococcus granulosus zinc finger protein 0.0023 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0276 0.0464
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0093 0.0086
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0055 0.0231 0.0891
Loa Loa (eye worm) hypothetical protein 0.0041 0.0151 0.0188
Brugia malayi Death domain containing protein 0.0064 0.028 0.0359
Mycobacterium ulcerans thioesterase TesA 0.0043 0.0162 0.0509
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0093 0.0111
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0054 0.0061
Leishmania major cathepsin L-like protease 0.0019 0.002 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.002 0.0061
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.003 0.0175
Schistosoma mansoni hypothetical protein 0.0102 0.0503 0.0845
Leishmania major cathepsin L-like protease 0.0072 0.0329 0.1921
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0329 0.1921
Echinococcus multilocularis survival motor neuron protein 1 0.05 0.2816 0.2811

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 4 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 4.16 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8.49 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 9.7 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 25 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 63 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 100 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 4.29 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 25 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 63 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 100 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.74 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.1799 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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