Detailed information for compound 61142

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.381 | Formula: C21H18F3N3O3
  • H donors: 2 H acceptors: 3 LogP: 1.38 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H]1C[C@H](N(C1)c1cc2n(cc(c(=O)c2cc1F)C(=O)O)c1ccc(cc1F)F)C
  • InChi: 1S/C21H18F3N3O3/c1-10-4-12(25)8-26(10)19-7-18-13(6-16(19)24)20(28)14(21(29)30)9-27(18)17-3-2-11(22)5-15(17)23/h2-3,5-7,9-10,12H,4,8,25H2,1H3,(H,29,30)/t10-,12+/m1/s1
  • InChiKey: CQSCBORSOIETFL-PWSUYJOCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi notch-like transmembrane receptor 0.0089 0.0314 0.0314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0067 0.0069
Toxoplasma gondii cathepsin CPC2 0.0127 0.0521 0.0591
Trypanosoma cruzi cysteine peptidase, putative 0.0559 0.292 0.3571
Onchocerca volvulus 0.022 0.104 0.1262
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0314 0.0314
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0183 0.0832 0.2824
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Brugia malayi Cell death protein 3 precursor 0.0167 0.0745 0.0745
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.104 0.1262
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0273 0.1331 0.1628
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0144 0.0614 0.0751
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0085 0.029 0.0964
Trypanosoma cruzi metacaspase, putative 0.0105 0.04 0.0489
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Schistosoma mansoni cathepsin S (C01 family) 0.0127 0.0521 0.0626
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0521 0.0626
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Plasmodium falciparum centrin-1 0.007 0.0208 0.0582
Loa Loa (eye worm) hypothetical protein 0.0136 0.0571 0.0571
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Brugia malayi cathepsin L-like precursor 0.0384 0.1947 0.1947
Onchocerca volvulus 0.0089 0.0314 0.0372
Trypanosoma brucei Metacaspase-4 0.0105 0.04 0.0489
Loa Loa (eye worm) histone deacetylase 3 0.0085 0.029 0.029
Echinococcus granulosus transmembrane protease serine 3 0.022 0.104 0.1262
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1337 0.7234 0.8848
Plasmodium falciparum serine repeat antigen 4 0.0127 0.0521 0.167
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0127 0.0521 0.0521
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Schistosoma mansoni rab 0.007 0.0208 0.0242
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0127 0.0521 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.0521 0.1756
Schistosoma mansoni calpain-7 (C02 family) 0.0478 0.2468 0.301
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Echinococcus multilocularis neural cadherin 0.0089 0.0314 0.0372
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.1507 0.8175 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0183 0.0832 0.2753
Plasmodium vivax histone deacetylase 2, putative 0.0096 0.0349 0.1072
Echinococcus multilocularis neurogenic locus notch protein 0.0089 0.0314 0.0372
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Toxoplasma gondii EGF family domain-containing protein 0.0089 0.0314 0.0336
Schistosoma mansoni axis inhibition protein axin 0.004 0.0038 0.0035
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0038 0.0035
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0302 0.1493 0.5098
Brugia malayi PXA domain containing protein 0.004 0.0038 0.0038
Toxoplasma gondii cathepsin CPL 0.0559 0.292 0.354
Leishmania major hypothetical protein, conserved 0.0211 0.0987 0.1207
Entamoeba histolytica calcium binding family protein 0.007 0.0208 0.0588
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Plasmodium falciparum proteasome subunit beta type-5 0.0083 0.028 0.0833
Trichomonas vaginalis calcium binding proteins, putative 0.007 0.0208 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0127 0.0521 0.1756
Loa Loa (eye worm) hypothetical protein 0.0167 0.0745 0.0745
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0506 0.0619
Toxoplasma gondii PAN domain-containing protein 0.0069 0.02 0.0196
Giardia lamblia Cathepsin B precursor 0.0127 0.0521 0.2412
Echinococcus granulosus caspase 0.0393 0.1997 0.2434
Schistosoma mansoni Mername-AA248 (C02 family) 0.0478 0.2468 0.301
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0559 0.292 0.292
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0459 0.0459
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0144 0.0614 0.0751
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Leishmania major histone deacetylase, putative 0.0096 0.0349 0.0427
Plasmodium vivax unspecified product 0.0127 0.0521 0.167
Schistosoma mansoni calmodulin 0.007 0.0208 0.0242
Brugia malayi prolyl oligopeptidase family protein 0.0505 0.262 0.262
Leishmania major cathepsin L-like protease 0.0559 0.292 0.3571
Brugia malayi Trypsin family protein 0.022 0.104 0.104
Echinococcus granulosus inhibitor of apoptosis protein 0.0136 0.0571 0.0687
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Echinococcus granulosus expressed protein 0.0776 0.4122 0.5036
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Schistosoma mansoni notch 0.0089 0.0314 0.0372
Onchocerca volvulus 0.0559 0.292 0.3564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Onchocerca volvulus Cathepsin L homolog 0.0127 0.0521 0.0626
Echinococcus multilocularis caspase 8 0.0105 0.04 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0035
Echinococcus multilocularis notch 0.0089 0.0314 0.0372
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0144 0.0614 0.0751
Toxoplasma gondii microneme protein MIC4 0.0069 0.02 0.0196
Echinococcus granulosus histone deacetylase 6 0.0096 0.0349 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Trypanosoma brucei Calpain-like protein 1.2 0.0144 0.0614 0.0751
Echinococcus multilocularis cathepsin L cysteine protease 0.0559 0.292 0.3564
Onchocerca volvulus 0.0559 0.292 0.3564
Toxoplasma gondii histone deacetylase HDAC2 0.0085 0.029 0.0308
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0136 0.0571 0.0687
Schistosoma mansoni centrin-related 0.007 0.0208 0.0242
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Toxoplasma gondii calcium binding egf domain-containing protein 0.0216 0.1015 0.1198
Trypanosoma cruzi hypothetical protein, conserved 0.0183 0.0832 0.1017
Trypanosoma cruzi centrin-3 0.007 0.0208 0.0254
Loa Loa (eye worm) hypothetical protein 0.0183 0.0832 0.0832
Echinococcus granulosus calpain A 0.0478 0.2468 0.301
Trypanosoma cruzi cysteine proteinase, putative 0.0302 0.1493 0.1827
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.004 0.0037
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0183 0.0832 0.1006
Leishmania major calcineurin B subunit, putative 0.007 0.0208 0.0254
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.022 0.104 0.1262
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Brugia malayi histone deacetylase 3 (HD3) 0.0085 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0175 0.079 0.079
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0559 0.292 1
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.038 0.1923 0.2343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Echinococcus multilocularis calpain family protein 1, d 0.0932 0.499 0.6099
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0127 0.0521 0.167
Echinococcus granulosus cathepsin L cysteine proteinase 0.0559 0.292 0.3564
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Echinococcus granulosus slit 2 protein 0.0089 0.0314 0.0372
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Loa Loa (eye worm) hypothetical protein 0.0051 0.0099 0.0099
Schistosoma mansoni inhibitor of apoptosis protein 0.0136 0.0571 0.0687
Giardia lamblia Cathepsin B precursor 0.0127 0.0521 0.2412
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Echinococcus granulosus proteasome prosome macropain 0.0083 0.028 0.0331
Onchocerca volvulus 0.0559 0.292 0.3564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0067 0.0069
Echinococcus granulosus protein jagged 2 0.0089 0.0314 0.0372
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0085 0.029 0.0964
Brugia malayi calpain 5 0.0144 0.0614 0.0614
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Loa Loa (eye worm) hypothetical protein 0.0175 0.079 0.079
Trichomonas vaginalis calcium binding protein, putative 0.007 0.0208 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Trichomonas vaginalis calmodulin, putative 0.0071 0.0213 0.0698
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0306 0.1514 0.1841
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0302 0.1493 0.1827
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0273 0.1331 0.1628
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0506 0.0608
Onchocerca volvulus 0.022 0.104 0.1262
Trypanosoma brucei Calpain-like protein 1.1 0.0144 0.0614 0.0751
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0177 0.0216
Echinococcus multilocularis EF hand domain containing family member A2 0.007 0.0208 0.0242
Brugia malayi programmed cell death protein 6 0.007 0.0208 0.0208
Schistosoma mansoni histone deacetylase 0.0085 0.029 0.0344
Echinococcus multilocularis histone deacetylase 3 0.0085 0.029 0.0344
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.007 0.0208 0.0254
Echinococcus granulosus protein jagged 2 0.0089 0.0314 0.0372
Echinococcus granulosus histone deacetylase 6 0.0102 0.0382 0.0456
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0038 0.0035
Trypanosoma brucei I/6 autoantigen 0.007 0.0208 0.0254
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0127 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Trypanosoma brucei metacaspase 0.0105 0.04 0.0489
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Loa Loa (eye worm) hypothetical protein 0.0789 0.4193 0.4193
Trypanosoma cruzi cysteine peptidase, putative 0.0657 0.3462 0.4235
Leishmania major histone deacetylase, putative 0.0085 0.029 0.0355
Loa Loa (eye worm) hypothetical protein 0.0306 0.1514 0.1514
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Trichomonas vaginalis calcineurin B subunit, putative 0.007 0.0208 0.068
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0038 0.0035
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0314 0.0314
Plasmodium falciparum serine repeat antigen 3 0.0127 0.0521 0.167
Loa Loa (eye worm) hypothetical protein 0.022 0.104 0.104
Trypanosoma cruzi cysteine peptidase, putative 0.0302 0.1493 0.1827
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.007 0.0208 0.0254
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.1493 0.1817
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Leishmania major cathepsin L-like protease 0.0657 0.3462 0.4235
Toxoplasma gondii calmodulin CAM1 0.0071 0.0213 0.0213
Echinococcus granulosus delta-like protein 1 0.0089 0.0314 0.0372
Toxoplasma gondii kringle domain-containing protein 0.0211 0.0987 0.1164
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0038 0.0035
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0127 0.0521 0.167
Leishmania major hypothetical protein, unknown function 0.0144 0.0614 0.0751
Echinococcus granulosus microtubule associated protein 2 0.1435 0.7776 0.9511
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1064 0.5718 0.6991
Plasmodium vivax vivapain-2 0.0559 0.292 1
Echinococcus multilocularis neurogenic locus protein delta 0.0089 0.0314 0.0372
Schistosoma mansoni reticulocalbin 0.007 0.0208 0.0242
Toxoplasma gondii centrin 0.007 0.0208 0.0206
Trypanosoma cruzi cysteine proteinase, putative 0.0302 0.1493 0.1827
Echinococcus granulosus caspase 8 0.0105 0.04 0.0478
Echinococcus granulosus acylamino acid releasing enzyme 0.0183 0.0832 0.1006
Giardia lamblia Cathepsin B precursor 0.0417 0.2128 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Plasmodium vivax hypothetical protein, conserved 0.0105 0.04 0.125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Trypanosoma cruzi calmodulin, putative 0.007 0.0208 0.0254
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.2047 0.2495
Leishmania major cysteine peptidase A (CPA) 0.0559 0.292 0.3571
Onchocerca volvulus Cathepsin F homolog 0.0559 0.292 0.3564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Trypanosoma brucei histone deacetylase 3 0.0096 0.0349 0.0427
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0306 0.1514 0.1841
Echinococcus granulosus tissue type plasminogen activator 0.0211 0.0987 0.1197
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.038 0.1923 0.2343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0521 0.1756
Brugia malayi Proteasome A-type and B-type family protein 0.0083 0.028 0.028
Trypanosoma cruzi metacaspase, putative 0.0105 0.04 0.0489
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Echinococcus multilocularis calbindin 32 0.0071 0.0213 0.0249
Loa Loa (eye worm) cathepsin B 0.0417 0.2128 0.2128
Schistosoma mansoni survival motor neuron protein 0.0049 0.0089 0.0097
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0083 0.028 0.0838
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1835 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Toxoplasma gondii preprocathepsin c precursor, putative 0.0127 0.0521 0.0591
Giardia lamblia High cysteine protein 0.0089 0.0314 0.1434
Trypanosoma brucei centrin, putative 0.007 0.0208 0.0254
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.007 0.0208 0.0254
Echinococcus granulosus dnaJ subfamily B 0.0402 0.2047 0.2495
Loa Loa (eye worm) hypothetical protein 0.1123 0.6047 0.6047
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0177 0.048
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0038 0.0098
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0105 0.04 0.0443
Toxoplasma gondii hypothetical protein 0.0144 0.0614 0.0706
Loa Loa (eye worm) hypothetical protein 0.0559 0.292 0.292
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0159 0.0183
Toxoplasma gondii histone deacetylase HDAC4 0.0041 0.0045 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0127 0.0521 0.1756
Brugia malayi Cathepsin L-like precursor 0.0384 0.1947 0.1947
Plasmodium falciparum histone deacetylase 1 0.0085 0.029 0.087
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.007 0.0208 0.0588
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Schistosoma mansoni egf-like domain protein 0.0216 0.1015 0.1231
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.028 0.0343
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.007 0.0208 0.0242
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0216 0.1015 0.1015
Trichomonas vaginalis hypothetical protein 0.0144 0.0614 0.2076
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Brugia malayi Trypsin family protein 0.0306 0.1514 0.1514
Loa Loa (eye worm) programmed cell death protein 6 0.0071 0.0213 0.0213
Loa Loa (eye worm) prolyl oligopeptidase 0.0505 0.262 0.262
Loa Loa (eye worm) PAN domain-containing protein 0.0069 0.02 0.02
Plasmodium falciparum serine repeat antigen 6 0.0127 0.0521 0.167
Echinococcus multilocularis calumenin 0.0071 0.0213 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trypanosoma brucei histone deacetylase, putative 0.0096 0.0349 0.0427
Echinococcus granulosus cathepsin b 0.1064 0.5718 0.6991
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Schistosoma mansoni cathepsin F (C01 family) 0.0384 0.1947 0.2373
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Leishmania major calpain family cysteine protease-like protein 0.0144 0.0614 0.0751
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0083 0.028 0.0343
Leishmania major protein kinase, putative 0.007 0.0208 0.0254
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Entamoeba histolytica cysteine protease, putative 0.0559 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0143 0.0164
Plasmodium falciparum serine repeat antigen 1 0.0127 0.0521 0.167
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0035
Onchocerca volvulus 0.0559 0.292 0.3564
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0127 0.0521 0.1756
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1507 0.8175 1
Trypanosoma cruzi hypothetical protein, conserved 0.0183 0.0832 0.1017
Giardia lamblia Cysteine protease 0.0127 0.0521 0.2412
Onchocerca volvulus Cathepsin L homolog 0.0559 0.292 0.3564
Trypanosoma cruzi centrin, putative 0.007 0.0208 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Entamoeba histolytica cysteine proteinase, putative 0.0384 0.1947 0.6625
Schistosoma mansoni caspase-3 (C14 family) 0.0393 0.1997 0.2434
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.004 0.0049
Onchocerca volvulus 0.0085 0.029 0.0344
Brugia malayi hypothetical protein 0.022 0.104 0.104
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0127 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0521 0.1756
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1064 0.5718 0.6995
Brugia malayi cathepsin F-like cysteine proteinase 0.0127 0.0521 0.0521
Plasmodium vivax hypothetical protein, conserved 0.0183 0.0832 0.2749
Giardia lamblia Cysteine protease 0.0127 0.0521 0.2412
Toxoplasma gondii cathepsin CPC1 0.0127 0.0521 0.0591
Loa Loa (eye worm) hypothetical protein 0.0175 0.079 0.079
Giardia lamblia Hypothetical protein 0.0127 0.0521 0.2412
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Loa Loa (eye worm) hypothetical protein 0.022 0.104 0.104
Trypanosoma brucei prolyl oligopeptidase, putative 0.0616 0.3234 0.3956
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0067 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0105 0.04 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0067 0.0069
Onchocerca volvulus 0.0089 0.0314 0.0372
Schistosoma mansoni slit 0.0089 0.0314 0.0372
Onchocerca volvulus 0.0559 0.292 0.3564
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0038 0.0038
Echinococcus multilocularis slit 2 protein 0.0089 0.0314 0.0372
Trypanosoma brucei calmodulin, putative 0.007 0.0208 0.0254
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0208 0.0582
Trichomonas vaginalis calcium binding protein, putative 0.007 0.0208 0.068
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Loa Loa (eye worm) hypothetical protein 0.1267 0.6844 0.6844
Trypanosoma brucei calmodulin, putative 0.0071 0.0213 0.026
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0183 0.0832 0.1017
Entamoeba histolytica calcium-binding protein, putative 0.007 0.0208 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0384 0.1947 0.6658
Toxoplasma gondii microneme protein, putative 0.0069 0.02 0.0196
Plasmodium falciparum cysteine proteinase falcipain 3 0.0559 0.292 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1064 0.5718 0.6991
Echinococcus granulosus neurogenic locus notch protein 0.0089 0.0314 0.0372
Echinococcus granulosus histone deacetylase 3 0.0085 0.029 0.0344
Trypanosoma cruzi cysteine peptidase, putative 0.0657 0.3462 0.4235
Brugia malayi Histone deacetylase family protein 0.0096 0.0349 0.0349
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Onchocerca volvulus 0.0155 0.0679 0.082
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Plasmodium falciparum peptidase, putative 0.0183 0.0832 0.2749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Giardia lamblia Cathepsin B precursor 0.0127 0.0521 0.2412
Echinococcus granulosus histone deacetylase 7 0.0096 0.0349 0.0415
Echinococcus multilocularis protein jagged 1 0.0089 0.0314 0.0372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0521 0.1756
Echinococcus multilocularis Mastin 0.0754 0.4001 0.4888
Trypanosoma brucei kinesin, putative 0.0334 0.1671 0.2044
Giardia lamblia Cysteine protease 0.0127 0.0521 0.2412
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Plasmodium vivax histone deacetylase, putative 0.0041 0.0045 0.0019
Leishmania major phospholipase c-like protein 0.007 0.0208 0.0254
Trypanosoma brucei Calpain-like protein 2 0.0144 0.0614 0.0751
Echinococcus granulosus EF hand domain containing family member A2 0.007 0.0208 0.0242
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0334 0.1671 0.5666
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0273 0.1331 0.1618
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0089 0.0314 0.0372
Echinococcus granulosus apoptotic protease activating factor 1 0.0062 0.0162 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0159 0.0183
Brugia malayi hypothetical protein 0.024 0.1151 0.1151
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0089 0.0314 0.0372
Echinococcus multilocularis microtubule associated protein 2 0.1435 0.7776 0.9511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Toxoplasma gondii cathepsin B 0.0417 0.2128 0.2567
Leishmania major calmodulin-like protein 0.007 0.0208 0.0254
Brugia malayi calpain family protein 1 0.1267 0.6844 0.6844
Schistosoma mansoni caspase-7 (C14 family) 0.0167 0.0745 0.09
Schistosoma mansoni laminin gamma-3 chain 0.0089 0.0314 0.0372
Brugia malayi cathepsin F-like cysteine proteinase 0.0175 0.079 0.079
Entamoeba histolytica protein kinase, putative 0.0334 0.1671 0.5666
Onchocerca volvulus Cathepsin L homolog 0.0559 0.292 0.3564
Schistosoma mansoni notch 0.0089 0.0314 0.0372
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0136 0.0571 0.0687
Brugia malayi Papain family cysteine protease containing protein 0.0302 0.1493 0.1493
Loa Loa (eye worm) hypothetical protein 0.1064 0.5718 0.5718
Brugia malayi cathepsin L precursor 0.0127 0.0521 0.0521
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0144 0.0614 0.0751
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Plasmodium vivax centrin-1, putative 0.007 0.0208 0.0582
Loa Loa (eye worm) hypothetical protein 0.0216 0.1015 0.1015
Toxoplasma gondii PAN domain-containing protein 0.0069 0.02 0.0196
Echinococcus multilocularis EF HAND 1, calcium binding site 0.007 0.0208 0.0242
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0177 0.0475
Schistosoma mansoni microtubule-associated protein tau 0.1435 0.7776 0.9511
Brugia malayi Muscle positioning protein 4 0.0089 0.0314 0.0314
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0616 0.3234 0.3956
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0038 0.0035
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.033 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0208 0.068
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.007 0.0208 0.0254
Onchocerca volvulus 0.0069 0.02 0.0233
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.007 0.0208 0.0254
Echinococcus multilocularis EF hand domain containing family member A2 0.0071 0.0213 0.0249
Echinococcus granulosus neurogenic locus notch protein 0.0089 0.0314 0.0372
Echinococcus granulosus cathepsin L 0.0127 0.0521 0.0626
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0216 0.1015 0.1015
Plasmodium falciparum histone deacetylase 2 0.0096 0.0349 0.1072
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0506 0.0608
Schistosoma mansoni histone deacetylase 1 2 3 0.0041 0.0045 0.0044
Onchocerca volvulus 0.0069 0.02 0.0233
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0038 0.0035
Trypanosoma brucei histone deacetylase 1 0.0085 0.029 0.0355
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0616 0.3234 1
Plasmodium vivax histone deacetylase, putative 0.0096 0.0349 0.1072
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0127 0.0521 0.167
Brugia malayi prolyl oligopeptidase family protein 0.0183 0.0832 0.0832
Echinococcus multilocularis calpain 0.0478 0.2468 0.301
Echinococcus granulosus calcium uptake protein 1 0.0071 0.0213 0.0249
Onchocerca volvulus 0.0211 0.0987 0.1197
Brugia malayi Fibulin-1 precursor 0.0216 0.1015 0.1015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Loa Loa (eye worm) hypothetical protein 0.0211 0.0987 0.0987
Brugia malayi Protein kinase domain containing protein 0.0211 0.0987 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0302 0.1493 0.5098
Plasmodium falciparum metacaspase 1 0.0105 0.04 0.125
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Onchocerca volvulus Putative cubilin 0.0089 0.0314 0.0372
Trichomonas vaginalis calpain, putative 0.0144 0.0614 0.2076
Schistosoma mansoni hypothetical protein 0.022 0.104 0.1262
Leishmania major centrin, putative 0.007 0.0208 0.0254
Loa Loa (eye worm) TK/ROR protein kinase 0.0211 0.0987 0.0987
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Trypanosoma cruzi kinesin, putative 0.0334 0.1671 0.2044
Trichomonas vaginalis calpain, putative 0.0144 0.0614 0.2076
Trypanosoma cruzi caltractin, putative 0.007 0.0208 0.0254
Loa Loa (eye worm) calpain D 0.0144 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.007 0.0208 0.0208
Schistosoma mansoni calpain C (C02 family) 0.0478 0.2468 0.301
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0038 0.0035
Trypanosoma brucei Component of motile flagella 41 0.007 0.0208 0.0254
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Echinococcus multilocularis protein jagged 2 0.0089 0.0314 0.0372
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0183 0.0832 0.1006
Entamoeba histolytica prolyl oligopeptidase family protein 0.0183 0.0832 0.2753
Trypanosoma cruzi cruzipain precursor, putative 0.0657 0.3462 0.4235
Echinococcus granulosus calpain 7 C02 family 0.0478 0.2468 0.301
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0216 0.1015 0.1015
Plasmodium vivax vivapain-2 0.0559 0.292 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.1133 0.1133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.4422 0.5404
Echinococcus granulosus calpain 0.0478 0.2468 0.301
Brugia malayi Pre-SET motif family protein 0.0426 0.2181 0.2181
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.1493 0.1817
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0177 0.0216
Trichomonas vaginalis myosin light chain 1, putative 0.007 0.0208 0.068
Echinococcus granulosus neurocalcin 0.007 0.0208 0.0242
Trypanosoma cruzi calmodulin, putative 0.007 0.0208 0.0254
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0349 0.0427
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Echinococcus multilocularis enteropeptidase 0.0754 0.4001 0.4888
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Toxoplasma gondii troponin c, isotype gamma, putative 0.007 0.0208 0.0206
Trypanosoma brucei calpain-like protein, putative 0.0478 0.2468 0.3019
Leishmania major cathepsin L-like protease 0.0559 0.292 0.3571
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Entamoeba histolytica calmodulin, putative 0.007 0.0208 0.0588
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Plasmodium vivax histone deacetylase 1, putative 0.0085 0.029 0.087
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Trypanosoma cruzi calmodulin, putative 0.007 0.0208 0.0254
Brugia malayi cathepsin B-like cysteine proteinase 0.1064 0.5718 0.5718
Echinococcus multilocularis caspase 3 0.0288 0.1414 0.172
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Echinococcus granulosus centrin 2 0.007 0.0208 0.0242
Trypanosoma brucei calpain, putative 0.0144 0.0614 0.0751
Leishmania major programmed cell death 6 protein-like protein 0.007 0.0208 0.0254
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0506 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Echinococcus multilocularis tumor protein p63 0.0347 0.1745 0.2125
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Brugia malayi Cathepsin L-like cysteine proteinase 0.0384 0.1947 0.1947
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Brugia malayi Calmodulin-like protein 0.007 0.0208 0.0208
Giardia lamblia Cathepsin B precursor 0.0417 0.2128 1
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Plasmodium vivax SET domain protein, putative 0.0062 0.0159 0.0414
Echinococcus multilocularis transmembrane protease serine 3 0.022 0.104 0.1262
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.007 0.0208 0.068
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.007 0.0208 0.0254
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0071 0.0213 0.026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Echinococcus granulosus calpain 5 0.0478 0.2468 0.301
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0211 0.0987 0.3289
Onchocerca volvulus Histone deacetylase 10 homolog 0.0041 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0061 0.0154 0.0154
Leishmania major histone deacetylase, putative 0.0096 0.0349 0.0427
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.1493 0.505
Toxoplasma gondii histone deacetylase HDAC5 0.0041 0.0047 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Schistosoma mansoni hypothetical protein 0.007 0.0208 0.0242
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trypanosoma cruzi centrin, putative 0.007 0.0208 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0159 0.0183
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0144 0.0614 0.0751
Loa Loa (eye worm) fibroinase 0.0559 0.292 0.292
Toxoplasma gondii hypothetical protein 0.0183 0.0832 0.0973
Loa Loa (eye worm) PAN domain-containing protein 0.0069 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0216 0.1015 0.1015
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Onchocerca volvulus 0.0089 0.0314 0.0372
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0506 0.1565
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Echinococcus multilocularis neuronal calcium sensor 0.007 0.0208 0.0242
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Trypanosoma brucei histone deacetylase 2 0.0041 0.0045 0.0056
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0616 0.3234 0.3956
Schistosoma mansoni cathepsin B (C01 family) 0.0127 0.0521 0.0626
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0616 0.3234 0.3956
Brugia malayi Histone deacetylase 1 0.0085 0.029 0.029
Onchocerca volvulus Arrow homolog 0.0216 0.1015 0.1231
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0616 0.3234 0.3956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0273 0.1331 0.1587
Echinococcus multilocularis hypothetical protein 0.0478 0.2468 0.301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0067 0.0069
Entamoeba histolytica hypothetical protein, conserved 0.0183 0.0832 0.2753
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0083 0.028 0.0839
Echinococcus multilocularis calcium uptake protein 1 0.0071 0.0213 0.0249
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0038 0.0035
Trichomonas vaginalis calcium binding protein, putative 0.007 0.0208 0.068
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Trypanosoma cruzi cysteine peptidase, putative 0.0657 0.3462 0.4235
Loa Loa (eye worm) hypothetical protein 0.0062 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.1133 0.1376
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0038 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.1493 0.505
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0384 0.1947 0.6658
Trypanosoma cruzi metacaspase, putative 0.0105 0.04 0.0489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Schistosoma mansoni hypothetical protein 0.0144 0.0614 0.074
Giardia lamblia Cathepsin B precursor 0.0127 0.0521 0.2412
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.004 0.0037
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.004 0.0049
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0177 0.0216
Onchocerca volvulus Neurogenic locus notch homolog 0.009 0.0315 0.0374
Brugia malayi Thioredoxin family protein 0.0035 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0521 0.1756
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Trypanosoma cruzi oligopeptidase b 0.0616 0.3234 0.3956
Echinococcus granulosus cathepsin b 0.1064 0.5718 0.6991
Schistosoma mansoni centrin 0.007 0.0208 0.0242
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Echinococcus granulosus prolyl endopeptidase 0.1507 0.8175 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0175 0.079 0.079
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Brugia malayi prolyl oligopeptidase family protein 0.0183 0.0832 0.0832
Toxoplasma gondii subtilisin SUB12 0.0069 0.02 0.0196
Trypanosoma cruzi oligopeptidase b 0.0616 0.3234 0.3956
Onchocerca volvulus 0.0485 0.2509 0.3061
Leishmania major cathepsin L-like protease 0.0559 0.292 0.3571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0035
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0754 0.4001 0.4888
Schistosoma mansoni memapsin-2 (A01 family) 0.0433 0.2221 0.2708
Entamoeba histolytica grainin, putative 0.0071 0.0213 0.0606
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0085 0.029 0.0964
Schistosoma mansoni axis inhibition protein axin 0.004 0.0038 0.0035
Onchocerca volvulus 0.0559 0.292 0.3564
Loa Loa (eye worm) RGS-3 protein 0.004 0.0038 0.0038
Entamoeba histolytica calpain family cysteine protease, putative 0.0144 0.0614 0.1998
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Plasmodium vivax proteasome subunit beta type-5, putative 0.0083 0.028 0.0833
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.2181 0.2181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Trichomonas vaginalis centrin, putative 0.007 0.0208 0.068
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Toxoplasma gondii PAN domain-containing protein 0.0069 0.02 0.0196
Brugia malayi cathepsin Z-like cysteine proteinase 0.0127 0.0521 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Echinococcus multilocularis inhibitor of apoptosis protein 0.0136 0.0571 0.0687
Brugia malayi Cathepsin L-like precursor 0.0384 0.1947 0.1947
Echinococcus granulosus tumor protein p63 0.0347 0.1745 0.2125
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.1324 0.7161 1
Leishmania major centrin, putative 0.007 0.0208 0.0254
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Plasmodium falciparum serine repeat antigen 8 0.0127 0.0521 0.167
Trypanosoma brucei calpain-like protein, putative 0.0478 0.2468 0.3019
Toxoplasma gondii EFHC1, putative 0.007 0.0208 0.0206
Giardia lamblia Hypothetical protein 0.0127 0.0521 0.2412
Onchocerca volvulus 0.0069 0.02 0.0233
Plasmodium vivax serine-repeat antigen (SERA) 0.0127 0.0521 0.167
Brugia malayi cathepsin Z-like cysteine proteinase 0.0127 0.0521 0.0521
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Schistosoma mansoni neuronal calcium sensor 0.007 0.0208 0.0242
Onchocerca volvulus 0.0071 0.0213 0.0249
Entamoeba histolytica grainin 2 0.007 0.0208 0.0588
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Trichomonas vaginalis calcium binding protein, putative 0.007 0.0208 0.068
Echinococcus granulosus caspase 2 0.0167 0.0745 0.09
Echinococcus multilocularis caspase 2 0.0167 0.0745 0.09
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Echinococcus multilocularis cathepsin L 0.0302 0.1493 0.1817
Leishmania major centrin, putative,caltractin, putative 0.007 0.0208 0.0254
Trypanosoma brucei calpain-like protein, putative 0.0478 0.2468 0.3019
Giardia lamblia Alanyl dipeptidyl peptidase 0.0183 0.0832 0.3879
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Leishmania major oligopeptidase b 0.0616 0.3234 0.3956
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Schistosoma mansoni cell polarity protein 0.0089 0.0314 0.0372
Echinococcus granulosus EF HAND 1 calcium binding site 0.007 0.0208 0.0242
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0505 0.262 0.3197
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.0521 0.1756
Brugia malayi cathepsin L-like cysteine proteinase 0.0127 0.0521 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0067 0.0067
Toxoplasma gondii PAN/Apple domain-containing protein 0.0069 0.02 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Echinococcus granulosus sarcoplasmic calcium binding protein 0.007 0.0208 0.0242
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Onchocerca volvulus 0.0069 0.02 0.0233
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0273 0.1331 0.1628
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Onchocerca volvulus 0.022 0.104 0.1262
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0521 0.0626
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0127 0.0521 0.1675
Schistosoma mansoni histone deacetylase hda2 0.0041 0.0045 0.0044
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Mycobacterium ulcerans hypothetical protein 0.0035 0.001 0.0031
Onchocerca volvulus 0.0384 0.1947 0.2373
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0099 0.011
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.022 0.104 0.1262
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.1493 0.505
Trypanosoma cruzi I/6 autoantigen, putative 0.007 0.0208 0.0254
Plasmodium falciparum cysteine repeat modular protein 1 0.0211 0.0987 0.3289
Schistosoma mansoni cathepsin C 0.0127 0.0521 0.0626
Trypanosoma cruzi major cysteine proteinase, putative 0.0225 0.1064 0.1301
Onchocerca volvulus 0.0306 0.1514 0.1841
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0521 0.0626
Plasmodium vivax metacaspase 1, putative 0.0105 0.04 0.125
Echinococcus multilocularis centrin 2 0.007 0.0208 0.0242
Loa Loa (eye worm) histone deacetylase 7A 0.0096 0.0349 0.0349
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0105 0.04 0.0478
Toxoplasma gondii PAN domain-containing protein 0.0069 0.02 0.0196
Trypanosoma cruzi major cysteine proteinase, putative 0.0127 0.0521 0.0637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0067 0.0069
Echinococcus multilocularis calmodulin 0.007 0.0208 0.0242
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0177 0.0168
Onchocerca volvulus 0.0127 0.0521 0.0626
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Brugia malayi PXA domain containing protein 0.004 0.0038 0.0038
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0273 0.1331 0.1618
Leishmania major hypothetical protein, conserved 0.007 0.0208 0.0254
Onchocerca volvulus 0.0559 0.292 0.3564
Mycobacterium ulcerans transglutaminase family protein 0.0035 0.001 0.0031
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0035
Plasmodium vivax calpain, putative 0.0478 0.2468 0.8431
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0038 0.0038
Echinococcus granulosus neurogenic locus protein delta 0.0089 0.0314 0.0372
Schistosoma mansoni cathepsin s 0.0175 0.079 0.0955
Loa Loa (eye worm) PAN domain-containing protein 0.0069 0.02 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0067 0.0069
Leishmania major cathepsin L-like protease 0.0559 0.292 0.3571
Onchocerca volvulus 0.0789 0.4193 0.5123
Loa Loa (eye worm) calpain family protein 1 0.1267 0.6844 0.6844
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0127 0.0521 0.167
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0177 0.0177
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Schistosoma mansoni mitochondrial solute carrier 0.007 0.0208 0.0242
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.022 0.104 0.1262
Schistosoma mansoni notch 0.0089 0.0314 0.0372
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0126 0.0106
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Plasmodium falciparum serine repeat antigen 5 0.0127 0.0521 0.167
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0127 0.0521 0.2412
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Echinococcus granulosus cathepsin l1 0.0559 0.292 0.3564
Entamoeba histolytica cysteine proteinase 1, putative 0.0302 0.1493 0.505
Onchocerca volvulus Cell death protein 3 homolog 0.0167 0.0745 0.09
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0083 0.028 0.1275
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.022 0.104 0.1262
Brugia malayi GCC2 and GCC3 family protein 0.0089 0.0314 0.0314
Plasmodium vivax vivapain-3 0.0302 0.1493 0.5047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0144 0.0614 0.0751
Echinococcus granulosus Dipeptidyl peptidase 9 0.0273 0.1331 0.1618
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0393 0.1997 0.2434
Brugia malayi proteasome subunit beta type 1 0.0065 0.0177 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0162 0.0186
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0482 0.249 0.3046
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1151 0.1397
Echinococcus multilocularis histone deacetylase 0.0096 0.0349 0.0415
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0571 0.0571
Echinococcus multilocularis histone deacetylase 1 0.0085 0.029 0.0344
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0216 0.1015 0.1015
Trypanosoma brucei histone deacetylase 4 0.0096 0.0349 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0136 0.0571 0.0687
Echinococcus granulosus laminin 0.0216 0.1015 0.1231
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0521 0.0626
Loa Loa (eye worm) hypothetical protein 0.022 0.104 0.104
Plasmodium falciparum serine repeat antigen 9 0.0127 0.0521 0.167
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0208 0.068
Leishmania major metacaspase, putative 0.0105 0.04 0.0489
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0127 0.0521 0.167
Leishmania major cathepsin L-like protease 0.0657 0.3462 0.4235
Echinococcus granulosus calbindin 32 0.0071 0.0213 0.0249
Echinococcus multilocularis prolyl endopeptidase 0.1507 0.8175 1
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0177 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0302 0.1493 0.1493
Schistosoma mansoni histone deacetylase 4 5 0.0096 0.0349 0.0415
Giardia lamblia Encystation-specific protease 0.0127 0.0521 0.2412
Onchocerca volvulus 0.0089 0.0314 0.0372
Leishmania major calmodulin, putative 0.007 0.0208 0.0254
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.1133 0.1376
Brugia malayi calpain family protein 1 0.1267 0.6844 0.6844
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.004 0.004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0417 0.2128 0.2594
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0083 0.028 0.0378
Entamoeba histolytica prolyl oligopeptidase family protein 0.0183 0.0832 0.2753
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.104 0.1262
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0832 0.2824
Onchocerca volvulus 0.0069 0.02 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Onchocerca volvulus 0.0069 0.02 0.0233
Brugia malayi Trypsin-like protease protein 5 0.022 0.104 0.104
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.104 0.1262
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0127 0.0521 0.167
Entamoeba histolytica hypothetical protein 0.0127 0.0521 0.1675
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0127 0.0521 0.2412
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1064 0.5718 0.6991
Brugia malayi proteasome subunit beta type 2 0.004 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Toxoplasma gondii histone deacetylase HDAC1 0.0096 0.0349 0.038
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Plasmodium falciparum metacaspase-like protein 0.0105 0.04 0.125
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0159 0.0183
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.033 0.0404
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0183 0.0832 0.0973
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Trypanosoma brucei antigen, putative 0.0478 0.2468 0.3019
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0349 0.0427
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Leishmania major kinesin, putative 0.0334 0.1671 0.2044
Echinococcus granulosus cathepsin l cysteine peptidase 0.0559 0.292 0.3564
Onchocerca volvulus 0.0051 0.0099 0.011
Trypanosoma cruzi I/6 autoantigen, putative 0.007 0.0208 0.0254
Entamoeba histolytica histone deacetylase, putative 0.0085 0.029 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0521 0.0521
Toxoplasma gondii hypothetical protein 0.0069 0.02 0.0196
Echinococcus granulosus notch 0.0089 0.0314 0.0372
Brugia malayi calpain 5 0.0334 0.1671 0.1671
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Echinococcus multilocularis expressed protein 0.0776 0.4122 0.5036
Schistosoma mansoni notch 0.0089 0.0314 0.0372
Plasmodium vivax unspecified product 0.0302 0.1493 0.5047
Schistosoma mansoni calmodulin related calcium binding protein 0.007 0.0208 0.0242
Echinococcus multilocularis tissue type plasminogen activator 0.0211 0.0987 0.1197
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.1493 0.505
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Brugia malayi Histone deacetylase family protein 0.0096 0.0349 0.0349
Giardia lamblia Cathepsin L-like protease 0.0127 0.0521 0.2412
Echinococcus multilocularis cathepsin b 0.1064 0.5718 0.6991
Brugia malayi calpain 7 0.0478 0.2468 0.2468
Echinococcus granulosus neural cadherin 0.0089 0.0314 0.0372
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0521 0.0521
Giardia lamblia Cathepsin B precursor 0.0417 0.2128 1
Toxoplasma gondii EF hand domain-containing protein 0.007 0.0208 0.0206
Onchocerca volvulus 0.007 0.0208 0.0242
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0038 0.0038
Schistosoma mansoni calpain-2 (C02 family) 0.0144 0.0614 0.074
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Loa Loa (eye worm) Notch2 0.0089 0.0314 0.0314
Toxoplasma gondii microneme protein MIC17C 0.0069 0.02 0.0196
Loa Loa (eye worm) hypothetical protein 0.0175 0.079 0.079
Trichomonas vaginalis calpain, putative 0.0144 0.0614 0.2076
Echinococcus granulosus EF hand domain containing family member A2 0.0071 0.0213 0.0249
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Toxoplasma gondii hypothetical protein 0.0069 0.02 0.0196
Onchocerca volvulus 0.022 0.104 0.1262
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0506 0.0608
Schistosoma mansoni neuronal calcium sensor 0.007 0.0208 0.0242
Echinococcus granulosus neuronal calcium sensor 0.007 0.0208 0.0242
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0506 0.0608
Schistosoma mansoni hypothetical protein 0.0402 0.2047 0.2495
Trypanosoma cruzi cysteine protease, putative 0.0302 0.1493 0.1827
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0127 0.0521 0.167
Leishmania major hypothetical protein, conserved 0.0071 0.0213 0.026
Schistosoma mansoni hypothetical protein 0.0062 0.0162 0.0186
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.022 0.104 0.1262
Toxoplasma gondii histone deacetylase HDAC3 0.0085 0.029 0.0308
Toxoplasma gondii microneme protein MIC17A 0.0069 0.02 0.0196
Echinococcus multilocularis cathepsin L 0.0127 0.0521 0.0626
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Echinococcus multilocularis apoptotic protease activating factor 1 0.0062 0.0162 0.0186
Loa Loa (eye worm) hypothetical protein 0.0085 0.029 0.029
Echinococcus multilocularis cathepsin L cysteine protease 0.0559 0.292 0.3564
Loa Loa (eye worm) hypothetical protein 0.0384 0.1947 0.1947
Brugia malayi fibroinase precursor 0.0127 0.0521 0.0521
Trypanosoma brucei calpain-like protein, putative 0.0478 0.2468 0.3019
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0183 0.0832 0.2824
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0506 0.1565
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0127 0.0521 0.2412
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0144 0.0614 0.0706
Trypanosoma brucei prolyl endopeptidase 0.1507 0.8175 1
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Brugia malayi Cytochrome P450 family protein 0.0054 0.0119 0.0119
Trypanosoma brucei protein I/6 0.007 0.0208 0.0254
Echinococcus multilocularis fat cadherin tumor suppressor 0.0089 0.0314 0.0372
Trypanosoma cruzi conserved protein 0.0144 0.0614 0.0751
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0069 0.02 0.0196
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.007 0.0208 0.0242
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0506 0.0573
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0559 0.292 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0127 0.0521 0.0626
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1337 0.7234 0.8848
Trypanosoma brucei metacaspase MCA2 0.0105 0.04 0.0489
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0177 0.0204
Trypanosoma brucei mitochondrial calcium uptake 1 0.007 0.0208 0.0254
Schistosoma mansoni cathepsin F (C01 family) 0.0559 0.292 0.3564
Onchocerca volvulus 0.0089 0.0314 0.0372
Schistosoma mansoni cathepsin F (C01 family) 0.0559 0.292 0.3564
Echinococcus granulosus cathepsin L cysteine protease 0.0302 0.1493 0.1817
Brugia malayi EF hand family protein 0.007 0.0208 0.0208
Onchocerca volvulus 0.0049 0.0089 0.0097
Brugia malayi Cathepsin L-like precursor 0.0175 0.079 0.079
Trypanosoma brucei cysteine peptidase C (CPC) 0.0417 0.2128 0.2603
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0038 0.0038
Echinococcus multilocularis neurogenic locus notch protein 0.0089 0.0314 0.0372
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1337 0.7234 0.8848
Trichomonas vaginalis calcineurin B subunit, putative 0.0071 0.0213 0.0698
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Onchocerca volvulus 0.0069 0.02 0.0233
Plasmodium vivax vivapain-1 0.0302 0.1493 0.5047
Trypanosoma brucei caltractin, putative 0.007 0.0208 0.0254
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0127 0.0521 0.167
Loa Loa (eye worm) PAN domain-containing protein 0.0069 0.02 0.02
Echinococcus multilocularis programmed cell death protein 0.007 0.0208 0.0242
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Trypanosoma brucei metacaspase MCA3 0.0105 0.04 0.0489
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Echinococcus granulosus histone deacetylase 8 0.0041 0.0045 0.0044
Trypanosoma cruzi kinesin, putative 0.0334 0.1671 0.2044
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0038 0.0038
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0071 0.0213 0.0249
Echinococcus granulosus histone deacetylase 0.0096 0.0349 0.0415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0127 0.0521 0.0626
Brugia malayi Calcium binding EGF domain containing protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0136 0.0571 0.0571
Echinococcus granulosus calumenin 0.0071 0.0213 0.0249
Brugia malayi hypothetical protein 0.004 0.0038 0.0038
Echinococcus granulosus caspase 3 0.0288 0.1414 0.172
Brugia malayi Trypsin family protein 0.022 0.104 0.104
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0038 0.0035
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Schistosoma mansoni histone deacetylase hda2 0.0102 0.0382 0.0456
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0478 0.2468 0.3019
Trichomonas vaginalis set domain proteins, putative 0.0485 0.2508 0.8584
Brugia malayi Trypsin family protein 0.022 0.104 0.104
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0127 0.0521 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.0521 0.1756
Loa Loa (eye worm) cysteine protease 0.0559 0.292 0.292
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0216 0.1015 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.004 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0559 0.292 1
Echinococcus granulosus protein jagged 1 0.0089 0.0314 0.0372
Echinococcus multilocularis caspase 0.0393 0.1997 0.2434
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.1507 0.8175 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0559 0.292 0.3564
Loa Loa (eye worm) histone deacetylase 0.0096 0.0349 0.0349
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.022 0.104 0.104
Toxoplasma gondii prolyl endopeptidase 0.1507 0.8175 1
Echinococcus multilocularis laminin 0.0216 0.1015 0.1231
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.1133 0.1133
Giardia lamblia Cathepsin B precursor 0.0127 0.0521 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0127 0.0521 0.1756
Brugia malayi Calcium binding EGF domain containing protein 0.0216 0.1015 0.1015
Echinococcus granulosus cathepsin l1 0.0384 0.1947 0.2373
Loa Loa (eye worm) calpain 5 0.0334 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Schistosoma mansoni neuronal calcium sensor 0.007 0.0208 0.0242
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Schistosoma mansoni hypothetical protein 0.0211 0.0987 0.1197
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.038 0.1923 0.2343
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Leishmania major calmodulin-like protein 0.007 0.0208 0.0254
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0038 0.0035
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0105 0.04 0.04
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0216 0.1015 0.1231
Trypanosoma brucei hypothetical protein 0.0144 0.0614 0.0751
Echinococcus granulosus glycoprotein Antigen 5 0.0754 0.4001 0.4888
Loa Loa (eye worm) calpain 0.0478 0.2468 0.2468
Giardia lamblia Histone deacetylase 0.0085 0.029 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Schistosoma mansoni hypothetical protein 0.007 0.0208 0.0242
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0177 0.0788
Brugia malayi Kringle domain containing protein 0.0211 0.0987 0.0987
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0083 0.028 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Echinococcus multilocularis calpain 5 0.0478 0.2468 0.301
Brugia malayi EF hand family protein 0.0071 0.0213 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1064 0.5718 0.6991
Loa Loa (eye worm) EF hand family protein 0.007 0.0208 0.0208
Echinococcus multilocularis Tolloid protein 1 0.0216 0.1015 0.1231
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0208 0.0254
Loa Loa (eye worm) histone deacetylase 1 0.0085 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0083 0.028 0.028
Schistosoma mansoni neuronal calcium sensor 0.007 0.0208 0.0242
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.004 0.0037
Loa Loa (eye worm) histone deacetylase 11 0.0041 0.0045 0.0045
Loa Loa (eye worm) prolyl oligopeptidase 0.0183 0.0832 0.0832
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0105 0.04 0.0443
Loa Loa (eye worm) hypothetical protein 0.0062 0.0159 0.0159
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Schistosoma mansoni reticulocalbin 0.0071 0.0213 0.0249
Echinococcus granulosus histone deacetylase 1 0.0085 0.029 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0105 0.04 0.0443
Echinococcus granulosus calmodulin 0.007 0.0208 0.0242
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0177 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0417 0.2128 0.728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Schistosoma mansoni calpain-7 (C02 family) 0.0478 0.2468 0.301
Echinococcus granulosus Tolloid protein 1 0.0216 0.1015 0.1231
Schistosoma mansoni cercarial elastase (S01 family) 0.022 0.104 0.1262
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Onchocerca volvulus 0.022 0.104 0.1262
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.004 0.0006
Trichomonas vaginalis calmodulin, putative 0.007 0.0208 0.068
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0183 0.0832 0.2753
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0035
Echinococcus multilocularis neurogenic locus protein delta 0.0089 0.0314 0.0372
Trypanosoma cruzi metacaspase 5, putative 0.0105 0.04 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Brugia malayi hypothetical protein 0.0062 0.0162 0.0162
Onchocerca volvulus Deterin homolog 0.0136 0.0571 0.0687
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0127 0.0521 0.167
Brugia malayi prolyl oligopeptidase family protein 0.1507 0.8175 0.8175
Echinococcus multilocularis cathepsin b 0.1064 0.5718 0.6991
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.1493 0.1817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0478 0.2468 0.3019
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1337 0.7234 0.8848
Loa Loa (eye worm) hypothetical protein 0.0155 0.0679 0.0679
Trichomonas vaginalis histone deacetylase, putative 0.0085 0.029 0.0964
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0159 0.0183
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0045 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0038 0.0035
Echinococcus granulosus axis inhibition protein axin 0.004 0.0038 0.0035
Echinococcus multilocularis calpain 7 (C02 family) 0.0478 0.2468 0.301
Trypanosoma brucei metacaspase 5, putative 0.0105 0.04 0.0489
Entamoeba histolytica hypothetical protein, conserved 0.0071 0.0213 0.0606
Giardia lamblia Cathepsin L-like protease 0.0127 0.0521 0.2412
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0616 0.3234 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0083 0.028 0.0331
Schistosoma mansoni hypothetical protein 0.0089 0.0314 0.0372
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Trypanosoma cruzi cruzipain precursor, putative 0.0175 0.079 0.0966
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0505 0.262 0.3197
Brugia malayi prolyl oligopeptidase family protein 0.0273 0.1331 0.1331
Brugia malayi EGF-like domain containing protein 0.0089 0.0314 0.0314
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Brugia malayi MH2 domain containing protein 0.0116 0.0459 0.0459
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0616 0.3234 0.4508
Loa Loa (eye worm) hypothetical protein 0.024 0.1151 0.1151
Echinococcus multilocularis neurogenic locus notch protein 4 0.0089 0.0314 0.0372
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0273 0.1331 0.1628
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.0521 0.1756
Giardia lamblia Alanyl dipeptidyl peptidase 0.0183 0.0832 0.3879
Echinococcus multilocularis acylamino acid releasing enzyme 0.0183 0.0832 0.1006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Brugia malayi Papain family cysteine protease containing protein 0.0127 0.0521 0.0521
Echinococcus multilocularis histone deacetylase 7 0.0096 0.0349 0.0415
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.004 0.0103
Schistosoma mansoni hypothetical protein 0.022 0.104 0.1262
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Entamoeba histolytica cysteine proteinase, putative 0.0559 0.292 1
Brugia malayi hypothetical protein 0.009 0.0316 0.0316
Toxoplasma gondii centrin, putative 0.007 0.0208 0.0206
Brugia malayi hypothetical protein 0.004 0.0038 0.0038
Leishmania major i/6 autoantigen-like protein 0.007 0.0208 0.0254
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Echinococcus granulosus programmed cell death protein 0.007 0.0208 0.0242
Onchocerca volvulus 0.0062 0.0159 0.0183
Loa Loa (eye worm) hypothetical protein 0.009 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0478 0.2468 0.3019
Onchocerca volvulus 0.0069 0.02 0.0233
Echinococcus multilocularis calmodulin 0.007 0.0208 0.0242
Trypanosoma brucei centrin, putative 0.007 0.0208 0.0254
Echinococcus multilocularis cysteine protease 0.0559 0.292 0.3564
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0038 0.0038
Entamoeba histolytica calmodulin, putative 0.007 0.0208 0.0588
Leishmania major proteasome beta 2 subunit, putative 0.004 0.004 0.0049
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1267 0.6844 0.837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0159 0.0183
Loa Loa (eye worm) hypothetical protein 0.007 0.0208 0.0208
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.007 0.0208 0.0588
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0127 0.0521 0.0626
Echinococcus granulosus enteropeptidase 0.0754 0.4001 0.4888
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.022 0.104 0.1262
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0559 0.292 0.3564
Loa Loa (eye worm) hypothetical protein 0.022 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0306 0.1514 0.1514
Plasmodium vivax unspecified product 0.0175 0.079 0.2604
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0127 0.0521 0.1756
Trypanosoma cruzi prolyl endopeptidase 0.1507 0.8175 1
Schistosoma mansoni notch 0.009 0.0315 0.0374
Mycobacterium ulcerans hypothetical protein 0.022 0.104 0.3217
Brugia malayi Delta serrate ligand family protein 0.0089 0.0314 0.0314
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0038 0.0035
Onchocerca volvulus 0.007 0.0208 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0127 0.0521 0.1756
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.004 0.0103
Echinococcus granulosus axis inhibition protein axin 0.004 0.0038 0.0035
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1151 0.1397
Trypanosoma brucei calpain, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Trypanosoma brucei Aph-1 protein, putative 0.0092 0.033 0.0404
Loa Loa (eye worm) hypothetical protein 0.0069 0.02 0.02
Trypanosoma cruzi histone deacetylase 1, putative 0.0085 0.029 0.0355
Loa Loa (eye worm) hypothetical protein 0.0216 0.1015 0.1015
Echinococcus multilocularis histone deacetylase 8 0.0041 0.0045 0.0044
Mycobacterium ulcerans proteasome PrcB 0.0083 0.028 0.0866
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Echinococcus multilocularis programmed cell death protein 0.007 0.0208 0.0242
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0083 0.028 0.0331
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.004 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0506 0.1565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0302 0.1493 0.1827
Echinococcus granulosus protein jagged 1 0.0089 0.0314 0.0372
Loa Loa (eye worm) calmodulin-like protein 0.007 0.0208 0.0208
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0127 0.0521 0.0521
Echinococcus multilocularis fibropellin Ia 0.0089 0.0314 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0302 0.1493 0.1827
Plasmodium falciparum serine repeat antigen 2 0.0127 0.0521 0.167
Echinococcus granulosus cysteine protease 0.0302 0.1493 0.1817
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0038 0.0098
Mycobacterium tuberculosis Probable peptidase 0.0616 0.3234 0.4508
Schistosoma mansoni ef hand domain family member A2 0.007 0.0208 0.0242
Trypanosoma cruzi metacaspase, putative 0.0105 0.04 0.0489
Leishmania major calmodulin, putative 0.007 0.0208 0.0254
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0038 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0038 0.0035
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Schistosoma mansoni calmodulin 0.007 0.0208 0.0242
Loa Loa (eye worm) calpain family protein 1 0.0932 0.499 0.499
Plasmodium falciparum serine repeat antigen 7 0.0127 0.0521 0.167
Schistosoma mansoni regulator of G protein signaling 0.004 0.0038 0.0035
Echinococcus multilocularis histone deacetylase 6 0.0096 0.0349 0.0415
Onchocerca volvulus 0.0069 0.02 0.0233
Loa Loa (eye worm) hypothetical protein 0.0384 0.1947 0.1947
Loa Loa (eye worm) hypothetical protein 0.022 0.104 0.104
Trypanosoma brucei oligopeptidase b 0.0616 0.3234 0.3956
Entamoeba histolytica prolyl oligopeptidase family protein 0.0183 0.0832 0.2753
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0127 0.0521 0.167
Entamoeba histolytica cysteine protease, putative 0.0302 0.1493 0.505
Brugia malayi calpain D 0.0144 0.0614 0.0614
Echinococcus multilocularis glycoprotein Antigen 5 0.0754 0.4001 0.4888
Trypanosoma cruzi metacaspase 5, putative 0.0105 0.04 0.0489
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0127 0.0521 0.0626
Toxoplasma gondii proteasome subunit beta type, putative 0.0083 0.028 0.0295
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Leishmania major cathepsin L-like protease 0.0657 0.3462 0.4235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Onchocerca volvulus 0.0062 0.0162 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0559 0.292 1
Echinococcus multilocularis neurocalcin 0.007 0.0208 0.0242
Loa Loa (eye worm) hypothetical protein 0.0932 0.499 0.499
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Leishmania major proteasome beta 5 subunit, putative 0.0083 0.028 0.0343
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0144 0.0614 0.0751
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, putative 0.0144 0.0614 0.0751
Trichomonas vaginalis calmodulin-2, putative 0.007 0.0208 0.068
Entamoeba histolytica cysteine protease, putative 0.0127 0.0521 0.1675
Loa Loa (eye worm) trypsin family protein 0.022 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.0089 0.0314 0.0314
Brugia malayi calcium-binding protein 0.007 0.0208 0.0208
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0505 0.262 0.3197
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0105 0.04 0.1341
Echinococcus granulosus fibropellin Ia 0.0089 0.0314 0.0372
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0159 0.0183
Loa Loa (eye worm) notch protein 0.0089 0.0314 0.0314
Brugia malayi hypothetical protein 0.0155 0.0679 0.0679
Toxoplasma gondii calcium-dependent protein kinase 0.0071 0.0213 0.0213
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0089 0.0089
Echinococcus multilocularis histone deacetylase 6 0.0096 0.0349 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0559 0.292 1
Entamoeba histolytica cysteine proteinase 2 0.0302 0.1493 0.505
Trichomonas vaginalis centrin, putative 0.007 0.0208 0.068
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0127 0.0521 0.167
Trypanosoma cruzi histone deacetylase, putative 0.0041 0.0045 0.0056
Echinococcus granulosus cathepsin L 0.0302 0.1493 0.1817
Schistosoma mansoni septate junction protein 0.0089 0.0314 0.0372
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0505 0.262 0.3197
Leishmania major calpain protease-like protein 0.0144 0.0614 0.0751
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0038 0.0035
Trypanosoma cruzi 20S proteasome subunit 0.004 0.004 0.0049
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0127 0.0521 0.1675
Brugia malayi histone deacetylase 11 0.0041 0.0045 0.0045
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0127 0.0521 0.167
Giardia lamblia Cysteine protease 0.0127 0.0521 0.2412
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0038 0.0038
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0177 0.0475
Loa Loa (eye worm) hypothetical protein 0.0183 0.0832 0.0832
Onchocerca volvulus 0.0136 0.0571 0.0687
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0136 0.0571 0.0571
Echinococcus multilocularis fibrillin 1 0.0216 0.1015 0.1231
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0083 0.028 0.0928
Giardia lamblia Hypothetical protein 0.0071 0.0213 0.0958
Loa Loa (eye worm) PAN domain-containing protein 0.0069 0.02 0.02
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0159 0.0147
Loa Loa (eye worm) ctsf protein 0.0559 0.292 0.292
Schistosoma mansoni calpain (C02 family) 0.0478 0.2468 0.301
Brugia malayi Pre-SET motif family protein 0.0062 0.0159 0.0159
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.007 0.0208 0.068
Schistosoma mansoni caspase-7 (C14 family) 0.0393 0.1997 0.2434
Schistosoma mansoni hypothetical protein 0.0049 0.0089 0.0097
Brugia malayi Cadherin domain containing protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0459 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.04 0.1341
Toxoplasma gondii microneme protein MIC17B 0.0069 0.02 0.0196
Plasmodium falciparum calpain 0.0144 0.0614 0.1994
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0987 0.1207
Echinococcus multilocularis histone deacetylase 6 0.0102 0.0382 0.0456
Brugia malayi histone deacetylase 1 (HD1) 0.0085 0.029 0.029
Toxoplasma gondii PAN domain-containing protein 0.0656 0.3456 0.4199
Giardia lamblia Proteasome subunit beta type 2 0.004 0.004 0.0142
Echinococcus multilocularis protein jagged 1 0.0089 0.0314 0.0372
Onchocerca volvulus 0.0069 0.02 0.0233
Echinococcus granulosus Mastin 0.0754 0.4001 0.4888
Mycobacterium ulcerans hypothetical protein 0.0035 0.001 0.0031
Echinococcus granulosus neurogenic locus notch protein 4 0.0089 0.0314 0.0372
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0559 0.292 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.1507 0.8175 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0417 0.2128 0.2603
Plasmodium falciparum cysteine proteinase falcipain 1 0.0302 0.1493 0.5047
Trypanosoma cruzi cysteine peptidase, putative 0.0175 0.079 0.0966
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0144 0.0614 0.0751
Brugia malayi Papain family cysteine protease containing protein 0.0559 0.292 0.292
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0177 0.0573
Brugia malayi PAN domain containing protein 0.0069 0.02 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.0614 0.2076
Schistosoma mansoni notch 0.0089 0.0314 0.0372
Onchocerca volvulus Slit protein homolog 0.0089 0.0314 0.0372
Echinococcus granulosus calpain A 0.1338 0.724 0.8854
Brugia malayi Cadherin domain containing protein 0.0089 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0216 0.1015 0.1015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0559 0.292 1
Mycobacterium ulcerans putative transglutaminase-like protein 0.0035 0.001 0.0031
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0273 0.1331 0.1628
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0177 0.0204
Brugia malayi Cathepsin L-like precursor 0.0559 0.292 0.292
Schistosoma mansoni histone deacetylase 0.0085 0.029 0.0344
Leishmania major histone deacetylase, putative 0.0085 0.029 0.0355
Trypanosoma cruzi histone deacetylase 1, putative 0.0085 0.029 0.0355
Loa Loa (eye worm) hypothetical protein 0.1507 0.8175 0.8175
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0144 0.0614 0.0751
Schistosoma mansoni hypothetical protein 0.0136 0.0571 0.0687
Toxoplasma gondii calcium binding egf domain-containing protein 0.0216 0.1015 0.1198
Loa Loa (eye worm) hypothetical protein 0.0384 0.1947 0.1947
Plasmodium falciparum histone deacetylase, putative 0.0096 0.0349 0.1072
Giardia lamblia Cathepsin L precursor 0.0127 0.0521 0.2412
Onchocerca volvulus 0.0069 0.02 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Echinococcus multilocularis cysteine protease 0.0559 0.292 0.3564
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0144 0.0614 0.2076
Echinococcus granulosus histone deacetylase 6 0.0096 0.0349 0.0415
Loa Loa (eye worm) hypothetical protein 0.0144 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0127 0.0521 0.0521
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0417 0.2128 0.2603
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.007 0.0208 0.0254
Leishmania major cathepsin L-like protease 0.0559 0.292 0.3571
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.1133 0.1376
Plasmodium vivax serine-repeat antigen (SERA) 0.0127 0.0521 0.167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.3462 0.4235
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0213 0.06
Trypanosoma brucei Calpain-like protein CALP1.3 0.0144 0.0614 0.0751
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0038 0.0038
Schistosoma mansoni histone deacetylase 4 5 0.0096 0.0349 0.0415
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0559 0.292 0.292
Trypanosoma brucei centrin-3 0.007 0.0208 0.0254
Echinococcus multilocularis calpain A 0.1338 0.724 0.8854
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0393 0.1997 0.2434
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0089 0.0314 0.0314
Toxoplasma gondii PAN domain-containing protein 0.0656 0.3456 0.4199
Trypanosoma cruzi histone deacetylase, putative 0.0096 0.0349 0.0427
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0127 0.0521 0.167

Activities

Activity type Activity value Assay description Source Reference
I50 (functional) = 18 ug ml-1 Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560 ChEMBL. 2840501
IC50 (functional) = 18 ug ml-1 Supercoiling inhibition assay using purified DNA gyrase isolated from Escherichia coli H560 ChEMBL. 2840501
logP (ADMET) = 0.03 Partition coefficient (logP) ChEMBL. 2840501
MIC (functional) = 0.39 ug ml-1 In vitro Minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P ChEMBL. 2840501
MIC (functional) = 0.39 ug ml-1 In vitro Minimum inhibitory concentration against Staphylococcus aureus CMX 686B ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against Staphylococcus aureus A5177 ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against Staphylococcus aureus 45 ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against S. epidermidis 3519 ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against Escherichia coli Juhl ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against Klebsiella pneumoniae 8045 ChEMBL. 2840501
MIC (functional) = 0.78 ug ml-1 In vitro Minimum inhibitory concentration against Escherichia coli Juhl ChEMBL. 2840501
MIC (functional) = 1.56 ug ml-1 In vitro Minimum inhibitory concentration against S. pyogenes 930 ChEMBL. 2840501
MIC (functional) = 3.1 ug ml-1 In vitro Minimum inhibitory concentration against S. faecium ATCC 8043 ChEMBL. 2840501
MIC (functional) = 3.1 ug ml-1 In vitro Minimum inhibitory concentration against Acinetobacter CMX 669 ChEMBL. 2840501
MIC (functional) = 5 ug ml-1 In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa 5007 ChEMBL. 2840501
MIC (functional) = 6.2 ug ml-1 In vitro Minimum inhibitory concentration against S. bovis A5169 ChEMBL. 2840501
MIC (functional) = 6.2 ug ml-1 In vitro Minimum inhibitory concentration against S. agalactiae CMX 508 ChEMBL. 2840501
MIC (functional) = 6.2 ug ml-1 In vitro Minimum inhibitory concentration against Pseudomonas aeruginosa K799/WT ChEMBL. 2840501
Solubility (ADMET) = 0.182 mg ml-1 Compound was evaluated for the solubility in Ringer's buffer solution ChEMBL. 2840501

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.