Detailed information for compound 62645

Basic information

Technical information
  • TDR Targets ID: 62645
  • Name: S-(2,6-dimethylphenyl) N-octadecylcarbamothio ate
  • MW: 433.733 | Formula: C27H47NOS
  • H donors: 1 H acceptors: 1 LogP: 11.61 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCCCCCNC(=O)Sc1c(C)cccc1C
  • InChi: 1S/C27H47NOS/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-28-27(29)30-26-24(2)21-20-22-25(26)3/h20-22H,4-19,23H2,1-3H3,(H,28,29)
  • InChiKey: FQIIYEXQUKJNGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-octadecylcarbamothioic acid S-(2,6-dimethylphenyl) ester
  • N-stearylthiocarbamic acid S-(2,6-dimethylphenyl) ester
  • S-(2,6-dimethylphenyl) (octadecylamino)methanethioate
  • (octadecylamino)methanethioic acid S-(2,6-dimethylphenyl) ester
  • (stearylamino)methanethioic acid S-(2,6-dimethylphenyl) ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Acyl-CoA:cholesterol acyltransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl-CoA:cholesterol acyltransferase   305 aa 258 aa 20.2 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl-CoA:cholesterol acyltransferase   305 aa 278 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Schistosoma mansoni lipoxygenase 0.0616 0.3797 0.4586
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0028 0.0034
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0033 0.004
Brugia malayi 6-phosphofructokinase 0.0107 0.0548 0.0662
Loa Loa (eye worm) tubulin alpha 2 0.0226 0.1309 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0033 0.004
Schistosoma mansoni loxhd1 0.0154 0.0852 0.1029
Leishmania major hypothetical protein, conserved 0.0026 0.0033 0.004
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0917 0.5721 0.6909
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0033 0.004
Loa Loa (eye worm) CBP-B 0.0137 0.0745 0.0899
Onchocerca volvulus 0.0377 0.2276 0.8049
Schistosoma mansoni tubulin subunit alpha 0.0917 0.5721 0.6909
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0137 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Echinococcus granulosus tubulin alpha chain 0.0917 0.5721 0.6909
Loa Loa (eye worm) tubulin beta chain 0.1319 0.828 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0164 0.0198
Echinococcus granulosus tubulin subunit TubB 0.0917 0.5721 0.6909
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0183 0.0221
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0241 0.0291
Toxoplasma gondii beta tubulin 0.1319 0.828 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0028 0.0099
Trypanosoma brucei epsilon tubulin 0.0718 0.4446 0.5351
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0393 0.0475
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.043 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.014 0.0169
Entamoeba histolytica hypothetical protein 0.007 0.0318 0.0384
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Echinococcus multilocularis Tubulin beta 2C chain 0.1319 0.828 0.828
Schistosoma mansoni tubulin subunit alpha 0.0314 0.1872 0.2261
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0241 0.0291
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0033 0.004
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0026 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0026 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.014 0.0169
Echinococcus multilocularis CREB binding protein 0.0032 0.0075 0.0075
Plasmodium vivax delta tubulin, putative 0.0314 0.1872 0.2261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0028 0.0034
Brugia malayi hypothetical protein 0.0049 0.0183 0.0221
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0137 0.0137
Schistosoma mansoni follistatin 0.0056 0.0225 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0026 0.0032
Trypanosoma brucei beta tubulin 0.1319 0.828 1
Echinococcus granulosus follistatin 0.0056 0.0225 0.0272
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0028 0.0034
Onchocerca volvulus 0.0065 0.0281 0.0992
Leishmania major protein kinase, putative 0.0025 0.0029 0.0035
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0186 0.0225
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0198 0.113 0.1365
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1319 0.828 0.828
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0082 0.0391 0.0472
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0137 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0028 0.0028
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0028 0.0099
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.034 0.2039 0.2462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Echinococcus multilocularis tubulin alpha 0.0692 0.428 0.428
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0137 0.0166
Loa Loa (eye worm) tubulin beta chain 0.0314 0.1872 0.2261
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0241 0.0241
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.043 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Trypanosoma cruzi tubulin gamma chain 0.0718 0.4449 0.5358
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0028 0.0034
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0186 0.0225
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0026 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0052 0.0104
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0186 0.0225
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0225 0.0272
Plasmodium falciparum glutathione reductase 0.0046 0.0164 0.0198
Schistosoma mansoni hypothetical protein 0.0067 0.0295 0.0356
Schistosoma mansoni CREB-binding protein 2 0.0198 0.113 0.1365
Echinococcus multilocularis geminin 0.0332 0.1986 0.1986
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0137 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0183 0.019
Echinococcus multilocularis peroxisome assembly protein 26 0.0917 0.5721 0.5721
Schistosoma mansoni polycystin 1-related 0.0154 0.0852 0.1029
Leishmania major glycerol uptake protein, putative 0.0026 0.0033 0.004
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0082 0.0391 0.0472
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Entamoeba histolytica hypothetical protein 0.007 0.0318 0.0384
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0225 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0057 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0028 0.0028
Trypanosoma cruzi tubulin delta chain 0.0477 0.2914 0.3499
Schistosoma mansoni hypothetical protein 0.0154 0.0852 0.1029
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0164 0.0198
Echinococcus granulosus tubulin beta 4A class IVa 0.1319 0.828 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0029 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Plasmodium falciparum tubulin beta chain 0.1319 0.828 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0026 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0028 0.0034
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0052 0.0063
Echinococcus multilocularis RUN 0.0154 0.0852 0.0852
Brugia malayi bZIP transcription factor family protein 0.0082 0.0393 0.0475
Schistosoma mansoni alpha tubulin 0.0917 0.5721 0.6909
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0542 0.2894
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0028 0.0034
Entamoeba histolytica tubulin alpha-1 chain 0.0917 0.5721 0.6909
Echinococcus multilocularis beta tubulin 0.1319 0.828 0.828
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0186 0.0225
Echinococcus multilocularis tubulin alpha 3 chain 0.0917 0.5721 0.5721
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0033 0.0033
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0171 0.0207
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0137 0.0166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.004
Toxoplasma gondii transporter, major facilitator family protein 0.0082 0.0391 0.0472
Loa Loa (eye worm) hypothetical protein 0.054 0.3313 0.4001
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0026 0.0026
Trypanosoma brucei alpha tubulin 0.0917 0.5721 0.6897
Brugia malayi hypothetical protein 0.0082 0.0391 0.0472
Loa Loa (eye worm) hhat protein 0.0026 0.0033 0.004
Echinococcus granulosus Polycystic kidney disease protein 0.0154 0.0852 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0315 0.038
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0033 0.004
Toxoplasma gondii beta-tubulin, putative 0.1319 0.828 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0548 0.2926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0028 0.0034
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0028 0.0034
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0548 0.0662
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0225
Leishmania major epsilon tubulin, putative 0.0718 0.4446 0.537
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0318 0.0384
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0028 0.0034
Trichomonas vaginalis tubulin epsilon chain, putative 0.1319 0.828 1
Trypanosoma brucei tubulin gamma chain 0.0718 0.4449 0.5354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Brugia malayi beta-tubulin, identical 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Echinococcus multilocularis musashi 0.0026 0.0037 0.0037
Echinococcus granulosus tubulin alpha 3 chain 0.0917 0.5721 0.6909
Schistosoma mansoni lamin 0.0026 0.0037 0.0045
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0186 0.0186
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0137 0.0166
Brugia malayi MBOAT family protein 0.0026 0.0033 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.0154 0.0852 0.1029
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0186 0.0225
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0542 0.2792
Leishmania major protein kinase, putative 0.0025 0.0029 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0057 0.0068
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0033 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0028 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.043 0.0519
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.014 0.0169
Echinococcus multilocularis CREB binding protein 0.0032 0.0075 0.0075
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0033 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0548 0.28
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0028 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0028 0.0034
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0315 0.0381
Brugia malayi phosphofructokinase 0.0107 0.0548 0.0662
Onchocerca volvulus 0.0025 0.0028 0.0099
Echinococcus granulosus tubulin gamma 1 chain 0.0718 0.4449 0.5373
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0033 0.004
Echinococcus multilocularis expressed protein 0.0056 0.0225 0.0225
Schistosoma mansoni organic anion transporter 0.0082 0.0391 0.0472
Leishmania major beta tubulin 0.1319 0.828 1
Echinococcus multilocularis expressed protein 0.0734 0.4553 0.4553
Brugia malayi Tubulin beta chain 0.0314 0.1872 0.2261
Brugia malayi tubulin alpha chain - mouse 0.0917 0.5721 0.6909
Plasmodium falciparum thioredoxin reductase 0.0046 0.0164 0.0198
Brugia malayi Tubulin alpha-2 chain 0.0917 0.5721 0.6909
Echinococcus granulosus Solute carrier organic anion transporter family 0.0082 0.0391 0.0472
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0548 0.0662
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0186 0.0194
Leishmania major delta tubulin, putative 0.0477 0.2914 0.3519
Plasmodium falciparum LCCL domain-containing protein 0.0154 0.0852 0.1029
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0548 0.0624
Loa Loa (eye worm) tubulin alpha chain 0.0917 0.5721 0.6909
Loa Loa (eye worm) tubulin beta-4 chain 0.1319 0.828 1
Leishmania major beta tubulin 0.1319 0.828 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0172 0.0207
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0137 0.0166
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Brugia malayi intermediate filament protein 0.0026 0.0037 0.0045
Brugia malayi MBOAT family protein 0.0026 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0315 0.038
Leishmania major beta tubulin 0.1319 0.828 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0052 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0121 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0315 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Schistosoma mansoni agrin 0.0056 0.0225 0.0272
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0028 0.0034
Echinococcus multilocularis jun protein 0.0082 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Loa Loa (eye worm) hypothetical protein 0.0154 0.0852 0.1029
Plasmodium falciparum tubulin gamma chain 0.0718 0.4449 0.5373
Trichomonas vaginalis tubulin beta chain, putative 0.0377 0.2276 0.2749
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0033 0.004
Loa Loa (eye worm) raf kinase 0.0042 0.0138 0.0167
Loa Loa (eye worm) tubulin alpha 2 0.0603 0.3717 0.4489
Trichomonas vaginalis tubulin, putative 0.0377 0.2276 0.2749
Echinococcus multilocularis Tubulin beta 2C chain 0.1319 0.828 0.828
Trypanosoma cruzi GUP1, putative 0.0026 0.0033 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0183 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0057 0.0068
Leishmania major beta tubulin 0.1319 0.828 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0164 0.0166
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0318 0.0318
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0137 0.0166
Mycobacterium tuberculosis Probable reductase 0.0106 0.0542 0.2894
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.004
Loa Loa (eye worm) tubulin alpha-3 chain 0.054 0.3313 0.4001
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0477 0.2914 0.3519
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0028 0.0034
Echinococcus granulosus single minded 2 0.0071 0.0318 0.0384
Loa Loa (eye worm) hypothetical protein 0.012 0.0634 0.0766
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0033 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0028 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0057 0.0068
Onchocerca volvulus 0.0058 0.0241 0.0853
Trichomonas vaginalis tubulin alpha chain, putative 0.0377 0.2276 0.2749
Trichomonas vaginalis tubulin alpha chain, putative 0.0377 0.2276 0.2749
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0028 0.0034
Entamoeba histolytica hypothetical protein 0.0042 0.0137 0.0166
Loa Loa (eye worm) hypothetical protein 0.0238 0.1387 0.1675
Leishmania major beta tubulin 0.1319 0.828 1
Plasmodium vivax tubulin alpha chain, putative 0.0917 0.5721 0.6909
Brugia malayi hypoxia-induced factor 1 0.0295 0.175 0.2113
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.043 0.0481
Schistosoma mansoni tubulin subunit alpha 0.0917 0.5721 0.6909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0348 0.042
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0028 0.0034
Leishmania major hypothetical protein, conserved 0.0049 0.0183 0.0221
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0548 0.0662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0028 0.0034
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0137 0.0166
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0137 0.0166
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0033 0.004
Loa Loa (eye worm) agrin synaptic family protein 0.0056 0.0225 0.0272
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.1314 0.1587
Onchocerca volvulus 0.0025 0.0026 0.0093
Trypanosoma brucei tubulin delta chain 0.0477 0.2914 0.3494
Trichomonas vaginalis porcupine, putative 0.0026 0.0033 0.004
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0548 0.0662
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0037 0.0045
Leishmania major beta tubulin 0.1319 0.828 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0314 0.1872 0.2261
Toxoplasma gondii beta-1 tubulin, putative 0.1319 0.828 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0028 0.0034
Brugia malayi Tubulin beta chain 0.0377 0.2276 0.2749
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0183 0.0221
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0033 0.0033
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0186 0.0225
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0026 0.0032
Echinococcus granulosus Tubulin beta 2C chain 0.1319 0.828 1
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0137 0.0137
Echinococcus multilocularis tubulin gamma 1 chain 0.0718 0.4449 0.4449
Giardia lamblia Epsilon tubulin 0.034 0.2039 0.2414
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0033 0.004
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0137 0.0166
Loa Loa (eye worm) hhat protein 0.0026 0.0033 0.004
Onchocerca volvulus 0.0026 0.0037 0.0131
Loa Loa (eye worm) CYP4Cod1 0.004 0.0121 0.0146
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0033 0.004
Leishmania major glycerol uptake protein, putative 0.0026 0.0033 0.004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0616 0.3797 0.4586
Plasmodium falciparum alpha tubulin 1 0.0917 0.5721 0.6909
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0548 0.0662
Loa Loa (eye worm) alpha-tubulin 0.0917 0.5721 0.6909
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0033 0.004
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0542 0.2894
Echinococcus multilocularis Tubulin alpha 1 chain 0.0917 0.5721 0.5721
Giardia lamblia Alpha-tubulin 0.0917 0.5721 0.6889
Giardia lamblia Beta tubulin 0.1319 0.828 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0917 0.5721 0.5721
Loa Loa (eye worm) hypothetical protein 0.0056 0.0225 0.0272
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0241 0.0291
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0057 0.0068
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0082 0.0391 0.0391
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0616 0.3797 0.3797
Brugia malayi Tubulin beta-1 chain 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.043 0.0519
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0548 0.0632
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Schistosoma mansoni hypothetical protein 0.0022 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0137 0.0166
Echinococcus granulosus tumor protein p63 0.0992 0.6195 0.7482
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0033 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.2469 0.2981
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0241 0.0291
Leishmania major beta tubulin 0.1319 0.828 1
Trypanosoma cruzi GUP1, putative 0.0026 0.0033 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0548 0.0662
Schistosoma mansoni hypothetical protein 0.007 0.0318 0.0384
Echinococcus granulosus tubulin alpha 0.0692 0.428 0.5169
Trypanosoma brucei cytochrome P450, putative 0.004 0.0121 0.0107
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0028 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.136 0.1642
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0057 0.0068
Entamoeba histolytica hypothetical protein 0.007 0.0318 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.043 0.0519
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0033 0.0033
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0134 0.0123
Trypanosoma brucei alpha tubulin 0.0917 0.5721 0.6897
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0052 1
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0137 0.0166
Onchocerca volvulus 0.0082 0.0391 0.1382
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0186 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0172 0.0207
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0617 0.3199
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0225 0.0272
Plasmodium falciparum alpha tubulin 2 0.0917 0.5721 0.6909
Brugia malayi alpha-tubulin 0.0917 0.5721 0.6909
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0164 0.0198
Trypanosoma brucei epsilon tubulin 0.0718 0.4446 0.5351
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.043 0.0519
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0548 0.0662
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0137 0.0166
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0183 0.019
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0037 0.0045
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0028 0.0034
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0057 0.0037
Echinococcus granulosus tubulin subunit beta 0.1319 0.828 1
Toxoplasma gondii alpha-tubulin I, putative 0.0917 0.5721 0.6909
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Onchocerca volvulus Putative organic anion transporter 0.0082 0.0391 0.1382
Brugia malayi hypothetical protein 0.0082 0.0391 0.0472
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.043 0.0519
Onchocerca volvulus Putative organic anion transporter 0.0082 0.0391 0.1382
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0315 0.038
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0033 0.004
Trypanosoma brucei alpha tubulin, putative 0.0377 0.2276 0.272
Schistosoma mansoni alpha tubulin 0.0917 0.5721 0.6909
Trichomonas vaginalis tubulin gamma chain, putative 0.0718 0.4446 0.537
Brugia malayi PAS domain containing protein 0.0095 0.0476 0.0575
Loa Loa (eye worm) doublecortin family protein 0.0154 0.0852 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0315 0.038
Onchocerca volvulus 0.0154 0.0852 0.3013
Toxoplasma gondii thioredoxin reductase 0.0046 0.0164 0.0198
Loa Loa (eye worm) tubulin beta-2A chain 0.1319 0.828 1
Brugia malayi Tubulin alpha chain 0.0314 0.1872 0.2261
Loa Loa (eye worm) hypothetical protein 0.0056 0.0225 0.0272
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0041
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Entamoeba histolytica tubulin alpha chain, putative 0.0917 0.5721 0.6909
Echinococcus granulosus tubulin alpha chain 0.0917 0.5721 0.6909
Schistosoma mansoni lamin 0.0026 0.0037 0.0045
Plasmodium vivax glutathione reductase, putative 0.0046 0.0164 0.0198
Echinococcus multilocularis tubulin alpha 1C chain 0.0917 0.5721 0.5721
Loa Loa (eye worm) hypothetical protein 0.0025 0.0026 0.0032
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0548 0.0662
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.014 0.0169
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0164 0.0874
Loa Loa (eye worm) tubulin alpha chain 0.0917 0.5721 0.6909
Schistosoma mansoni aryl hydrocarbon receptor 0.0095 0.0476 0.0575
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0137 0.0166
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Trypanosoma brucei beta tubulin 0.1319 0.828 1
Entamoeba histolytica hypothetical protein 0.007 0.0318 0.0384
Brugia malayi MH2 domain containing protein 0.0234 0.136 0.1642
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.014 0.014
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0028 0.0034
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0137 0.0166
Trypanosoma cruzi tubulin delta chain 0.0477 0.2914 0.3499
Plasmodium falciparum tubulin delta chain, putative 0.0314 0.1872 0.2261
Loa Loa (eye worm) tubulin gamma chain 0.0718 0.4449 0.5373
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Toxoplasma gondii tubulin, putative 0.0026 0.0035 0.0042
Brugia malayi ecdysteroid receptor 0.0025 0.0028 0.0034
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0548 0.0662
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0033 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0172 0.0207
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0318 0.0384
Leishmania major glycerol uptake protein, putative 0.0026 0.0033 0.004
Echinococcus multilocularis Tubulin beta 2C chain 0.1319 0.828 0.828
Echinococcus multilocularis hypothetical protein 0.0917 0.5721 0.5721
Echinococcus multilocularis lamin 0.0026 0.0037 0.0037
Schistosoma mansoni tubulin subunit alpha 0.0917 0.5721 0.6909
Loa Loa (eye worm) BEN-1 protein 0.1319 0.828 1
Echinococcus multilocularis tubulin alpha chain 0.0917 0.5721 0.5721
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0233 0.0281
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0082 0.0391 0.0391
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0033 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0028 0.0034
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0026 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0186 0.0194
Plasmodium vivax tubulin gamma chain, putative 0.0718 0.4449 0.5373
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0137 0.0166
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Entamoeba histolytica tubulin gamma chain 0.0718 0.4449 0.5373
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.014 0.0169
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0045
Brugia malayi Pre-SET motif family protein 0.0058 0.0241 0.0291
Trypanosoma brucei beta tubulin 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0225 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.014 0.0169
Echinococcus granulosus alpha tubulin 0.0917 0.5721 0.6909
Echinococcus multilocularis tubulin subunit beta 0.1319 0.828 0.828
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.043 0.0489
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0028 0.0034
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0186 0.0225
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0548 0.0662
Loa Loa (eye worm) beta-tubulin 0.1319 0.828 1
Onchocerca volvulus 0.0464 0.2828 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0718 0.4449 0.5373
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0028 0.0034
Brugia malayi sodium-independent organic anion transporter family protein 0.0082 0.0391 0.0472
Schistosoma mansoni tubulin subunit delta 0.0314 0.1872 0.2261
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0052 1
Brugia malayi glutathione reductase 0.0046 0.0164 0.0198
Echinococcus multilocularis tubulin delta chain 0.0314 0.1872 0.1872
Echinococcus multilocularis lipoxygenase domain containing protein 0.0154 0.0852 0.0852
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0617 0.3295
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0026 0.0032
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0052 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.1872 0.2261
Echinococcus granulosus beta tubulin 0.1319 0.828 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0171 0.0207
Schistosoma mansoni zinc finger protein 0.0026 0.0033 0.004
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0318 0.0318
Plasmodium vivax SET domain protein, putative 0.0058 0.0241 0.0291
Trichomonas vaginalis tubulin alpha chain, putative 0.0377 0.2276 0.2749
Brugia malayi Tubulin gamma chain 0.0718 0.4449 0.5373
Brugia malayi hypothetical protein 0.0032 0.0072 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0052 0.0063
Brugia malayi PXA domain containing protein 0.0042 0.0137 0.0166
Plasmodium vivax tubulin alpha chain, putative 0.0917 0.5721 0.6909
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0033 0.004
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0137 0.0166
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0057 0.0029
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.043 0.0519
Echinococcus granulosus RUN 0.0154 0.0852 0.1029
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.1552 0.1874
Onchocerca volvulus 0.0071 0.0318 0.1125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0028 0.0034
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0225 0.0272
Trypanosoma cruzi epsilon tubulin, putative 0.0718 0.4446 0.5355
Echinococcus multilocularis tumor protein p63 0.0992 0.6195 0.6195
Brugia malayi hypothetical protein 0.0065 0.0281 0.0339
Trichomonas vaginalis tubulin, putative 0.0341 0.2041 0.2465
Trichomonas vaginalis tubulin epsilon chain, putative 0.0917 0.5721 0.6909
Entamoeba histolytica tubulin family protein 0.1319 0.828 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0917 0.5721 0.6909
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0241 0.0291
Echinococcus granulosus microtubule associated protein 2 0.0675 0.4177 0.5044
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0137 0.0166
Leishmania major gamma-tubulin 0.0718 0.4449 0.5373
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0057 0.0029
Leishmania major trypanothione reductase 0.0046 0.0164 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0204 0.0246
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0225 0.0272
Giardia lamblia Gamma tubulin 0.0718 0.4449 0.5344
Loa Loa (eye worm) hypothetical protein 0.008 0.0379 0.0458
Echinococcus multilocularis follistatin 0.0056 0.0225 0.0225
Trypanosoma cruzi alpha tubulin, putative 0.0917 0.5721 0.6899
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.043 0.0519
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0033 0.004
Loa Loa (eye worm) hypothetical protein 0.0264 0.1552 0.1874
Loa Loa (eye worm) hypoxia-induced factor 1 0.0295 0.175 0.2113
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0225 0.0272
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Brugia malayi nuclear hormone receptor 0.0025 0.0028 0.0034
Schistosoma mansoni coup transcription factor 0.0025 0.0028 0.0034
Leishmania major glycerol uptake protein, putative 0.0026 0.0033 0.004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0315 0.0343
Echinococcus multilocularis tubulin epsilon chain 0.0718 0.4446 0.4446
Echinococcus multilocularis Tubulin alpha 1 chain 0.0917 0.5721 0.5721
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0028 0.0034
Echinococcus granulosus Tubulin beta 2C chain 0.1319 0.828 1
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0026 0.0032
Echinococcus granulosus tubulin alpha chain 0.0917 0.5721 0.6909
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0029 0.0003
Brugia malayi MAP kinase sur-1 0.005 0.0186 0.0225
Echinococcus granulosus lamin dm0 0.0026 0.0037 0.0045
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0057 0.0068
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0183 0.0182
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.4177 0.4177
Trichomonas vaginalis tubulin epsilon chain, putative 0.1319 0.828 1
Leishmania major zeta tubulin, putative 0.0587 0.3614 0.4365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.043 0.0519
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0033 0.0008
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0183 0.0221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0228 0.0275
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0225
Trypanosoma cruzi zeta tubulin, putative 0.0587 0.3614 0.4347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0028 0.0034
Trypanosoma brucei beta tubulin 0.1319 0.828 1
Echinococcus granulosus beta tubulin 0.1319 0.828 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0026 0.0032
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0033 0.004
Plasmodium vivax tubulin epsilon chain, putative 0.0718 0.4446 0.537
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0028 0.0099
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0121 0.0114
Loa Loa (eye worm) hypothetical protein 0.0603 0.3717 0.4489
Trypanosoma brucei epsilon tubulin 0.0692 0.428 0.515
Leishmania major beta tubulin 0.1319 0.828 1
Echinococcus granulosus Tubulin beta 2C chain 0.1319 0.828 1
Echinococcus granulosus Tubulin beta 2C chain 0.1319 0.828 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0314 0.1872 0.2261
Trichomonas vaginalis tubulin, putative 0.1319 0.828 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0057 0.0068
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0225 0.0272
Onchocerca volvulus Huntingtin homolog 0.012 0.0634 0.2242
Loa Loa (eye worm) hypothetical protein 0.0049 0.0183 0.0221
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.136 0.1642
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Toxoplasma gondii hypothetical protein 0.0026 0.0033 0.004
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0028 0.0034
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0377 0.2276 0.2749
Leishmania major beta tubulin 0.1319 0.828 1
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0548 0.0548
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0617 0.3295
Brugia malayi MBOAT family protein 0.0026 0.0033 0.004
Schistosoma mansoni hypothetical protein 0.0101 0.0515 0.0621
Brugia malayi Doublecortin family protein 0.0154 0.0852 0.1029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0201 0.0242
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0137 0.0166
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0548 0.2825
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0057 0.0037
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Loa Loa (eye worm) hypothetical protein 0.0154 0.0852 0.1029
Trichomonas vaginalis tubulin alpha chain, putative 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Echinococcus multilocularis lipoxygenase domain containing protein 0.0154 0.0852 0.0852
Trichomonas vaginalis tubulin alpha chain, putative 0.0692 0.428 0.5169
Trypanosoma cruzi beta tubulin, putative 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Brugia malayi SPARC precursor 0.0056 0.0225 0.0272
Echinococcus multilocularis CREB binding protein 0.0032 0.0075 0.0075
Echinococcus multilocularis tubulin alpha chain 0.0917 0.5721 0.5721
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0548 0.0662
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0052 0.0063
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.4177 0.5044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0201 0.0242
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0166
Schistosoma mansoni tubulin subunit gamma 0.0718 0.4449 0.5373
Schistosoma mansoni rab6-interacting 0.0154 0.0852 0.1029
Onchocerca volvulus 0.0082 0.0391 0.1382
Echinococcus multilocularis tubulin alpha 1C chain 0.0917 0.5721 0.5721
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.001 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0028 0.0034
Echinococcus multilocularis tubulin beta 1 chain 0.1319 0.828 0.828
Trypanosoma brucei protein kinase, putative 0.005 0.0186 0.0186
Brugia malayi tubulin alpha-2 chain 0.0917 0.5721 0.6909
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.1552 0.1874
Echinococcus granulosus tubulin alpha chain 0.0917 0.5721 0.6909
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0028 0.0028
Trichomonas vaginalis set domain proteins, putative 0.0464 0.2828 0.3415
Onchocerca volvulus 0.0082 0.0391 0.1382
Leishmania major glycerol uptake protein, putative 0.0026 0.0033 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0042 0.0137 0.0166
Giardia lamblia Alpha-tubulin 0.0917 0.5721 0.6889
Toxoplasma gondii protease inhibitor PI2 0.0056 0.0225 0.0272
Loa Loa (eye worm) hypothetical protein 0.0093 0.0461 0.0556
Plasmodium falciparum tubulin epsilon chain, putative 0.0718 0.4446 0.537
Echinococcus granulosus Tubulin alpha 1 chain 0.0917 0.5721 0.6909
Brugia malayi TAZ zinc finger family protein 0.0198 0.113 0.1365
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0186 0.0164
Mycobacterium tuberculosis Cell division protein FtsZ 0.0314 0.1872 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0028 0.0034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0393 0.0393
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0137 0.0137
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.043 0.0519
Giardia lamblia Delta tubulin 0.0314 0.1872 0.2212
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0028 0.0034
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0057 0.0057
Trichomonas vaginalis tubulin beta chain, putative 0.1319 0.828 1
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Echinococcus granulosus geminin 0.0332 0.1986 0.2398
Brugia malayi secreted modular calcium-binding protein 1 0.0056 0.0225 0.0272
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Trypanosoma cruzi zeta tubulin, putative 0.0587 0.3614 0.4347
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0603 0.3717 0.4489
Trichomonas vaginalis tubulin epsilon chain, putative 0.0917 0.5721 0.6909
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0542 0.2894
Echinococcus granulosus CREB binding protein 0.0122 0.0647 0.0781
Treponema pallidum cell division protein FtsZ 0.0314 0.1872 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0028 0.0034
Leishmania major beta tubulin 0.1319 0.828 1
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0028 0.0034
Leishmania major beta tubulin 0.1319 0.828 1
Brugia malayi prostaglandin transporter 0.0082 0.0391 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0241 0.0291
Plasmodium vivax multidomain scavenger receptor, putative 0.0154 0.0852 0.1029
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0102 0.0083
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0314 0.1872 0.2261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0171 0.0207
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.043 0.0481
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0057 0.0068
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0033 0.004
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0137 0.0166
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0548 0.0662
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.054 0.3313 0.4001
Leishmania major beta tubulin 0.1319 0.828 1
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0033 0.004
Trypanosoma brucei zeta tubulin, putative 0.0587 0.3614 0.4342
Trypanosoma brucei beta tubulin 0.0692 0.428 0.515
Echinococcus granulosus tubulin epsilon chain 0.0718 0.4446 0.537
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0033 0.004
Schistosoma mansoni rab6-interacting 0.0154 0.0852 0.1029
Echinococcus multilocularis tubulin subunit TubB 0.0917 0.5721 0.5721
Echinococcus multilocularis beta tubulin 0.1319 0.828 0.828
Trichomonas vaginalis tubulin, putative 0.0377 0.2276 0.2749
Echinococcus multilocularis CREB binding protein 0.0136 0.0734 0.0734
Leishmania major cytochrome p450-like protein 0.004 0.0121 0.0146
Loa Loa (eye worm) hypothetical protein 0.0917 0.5721 0.6909
Echinococcus granulosus tubulin alpha chain 0.0917 0.5721 0.6909
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0121 0.0146
Schistosoma mansoni hypothetical protein 0.0332 0.1986 0.2398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0245 0.0296
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0225
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0542 0.2894
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0548 0.2438
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0314 0.1872 0.5
Onchocerca volvulus 0.0026 0.0037 0.0131
Brugia malayi Pre-SET motif family protein 0.0408 0.2469 0.2981
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0026 0.0026
Leishmania major beta tubulin 0.1319 0.828 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0033 0.004
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0318 0.1127
Toxoplasma gondii alpha tubulin TUBA1 0.0917 0.5721 0.6909
Loa Loa (eye worm) alpha-tubulin 0.0917 0.5721 0.6909
Brugia malayi Cytochrome P450 family protein 0.004 0.0121 0.0146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0542 0.2894
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0028 0.0028
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0026 0.0032
Onchocerca volvulus Putative organic anion transporter 0.0082 0.0391 0.1382
Echinococcus multilocularis Tubulin beta 2C chain 0.1319 0.828 0.828
Brugia malayi MBOAT family protein 0.0026 0.0033 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0164 0.0198
Trypanosoma brucei zeta tubulin 0.0587 0.3614 0.4342
Trypanosoma cruzi epsilon tubulin, putative 0.0718 0.4446 0.5355
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.1552 0.1552
Entamoeba histolytica hypothetical protein 0.0042 0.0137 0.0166
Trypanosoma brucei trypanothione reductase 0.0046 0.0164 0.0159
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0241 0.0241
Brugia malayi Cell division protein ftsZ 0.0314 0.1872 0.2261
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0318 0.0384
Echinococcus granulosus intermediate filament protein 0.0026 0.0037 0.0045
Echinococcus granulosus Tubulin alpha 1 chain 0.0917 0.5721 0.6909
Brugia malayi Hhat protein 0.0026 0.0033 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0172 0.0207
Schistosoma mansoni hypothetical protein 0.0026 0.0033 0.004
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0137 0.0166
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0315 0.035
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0033 0.0033
Leishmania major beta tubulin 0.1319 0.828 1
Echinococcus granulosus CREB binding protein 0.0032 0.0075 0.0091
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0603 0.3717 0.4489
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0121 0.0114
Schistosoma mansoni organic anion transporter 0.0082 0.0391 0.0472
Onchocerca volvulus 0.0082 0.0391 0.1382
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.0286 0.0345
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Schistosoma mansoni regulator of G protein signaling 0.0043 0.0144 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.014 0.0169
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0028 0.0034
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0033 0.004
Echinococcus granulosus tubulin beta 1 chain 0.1319 0.828 1
Loa Loa (eye worm) tubulin beta-1 chain 0.1319 0.828 1
Onchocerca volvulus Huntingtin homolog 0.012 0.0634 0.2242
Echinococcus multilocularis tubulin alpha chain 0.0917 0.5721 0.5721
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0026 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0204 0.0246
Brugia malayi nuclear receptor NHR-88 0.0025 0.0028 0.0034
Brugia malayi 6-phosphofructokinase 0.0107 0.0549 0.0663
Mycobacterium ulcerans cell division protein FtsZ 0.0314 0.1872 1
Brugia malayi Tubulin alpha-2 chain 0.0917 0.5721 0.6909
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0052 0.0063
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0033 0.004
Brugia malayi Tubulin alpha chain 0.0917 0.5721 0.6909
Echinococcus multilocularis agrin 0.0056 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0286 0.0345
Schistosoma mansoni hypothetical protein 0.0332 0.1986 0.2398
Loa Loa (eye worm) BEN-1 protein 0.1319 0.828 1
Echinococcus granulosus Tubulin beta 2C chain 0.1319 0.828 1
Schistosoma mansoni alpha tubulin 0.0917 0.5721 0.6909
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0028 0.0034
Echinococcus granulosus lipoxygenase domain containing protein 0.0154 0.0852 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0028 0.0034
Schistosoma mansoni jun-related protein 0.0067 0.0295 0.0356
Loa Loa (eye worm) hypothetical protein 0.012 0.0634 0.0766
Giardia lamblia GTOR 0.0088 0.043 0.0459
Echinococcus multilocularis tubulin alpha chain 0.0917 0.5721 0.5721
Echinococcus granulosus tubulin alpha 1C chain 0.0917 0.5721 0.6909
Brugia malayi steroid hormone receptor 0.0025 0.0028 0.0034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0186 0.0186
Brugia malayi sodium-independent organic anion transporter family protein 0.0082 0.0391 0.0472
Entamoeba histolytica hypothetical protein 0.0026 0.0033 0.004
Mycobacterium leprae cell division protein FtsZ 0.0314 0.1872 1
Onchocerca volvulus 0.0154 0.0852 0.3013
Giardia lamblia Beta tubulin 0.1319 0.828 1
Loa Loa (eye worm) tubulin alpha 2 0.0603 0.3717 0.4489
Onchocerca volvulus 0.0145 0.0794 0.2809
Echinococcus granulosus jun protein 0.0082 0.0393 0.0475
Loa Loa (eye worm) hypothetical protein 0.0082 0.0391 0.0472
Leishmania major beta tubulin 0.1319 0.828 1
Brugia malayi hypothetical protein 0.0042 0.0137 0.0166
Trichomonas vaginalis tubulin gamma chain, putative 0.1319 0.828 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0692 0.428 0.5169
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0026 0.0032
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0137 0.0166
Schistosoma mansoni lipoxygenase 0.0338 0.2026 0.2447
Echinococcus granulosus lamin 0.0026 0.0037 0.0045
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0617 0.3295
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0033 0.004
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0225 0.0272
Echinococcus granulosus tubulin alpha 1C chain 0.0917 0.5721 0.6909
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0137 0.0137
Echinococcus multilocularis Tubulin beta 2C chain 0.1319 0.828 0.828
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0137 0.0137
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0137 0.0166
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0137 0.0166
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0033 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0034
Loa Loa (eye worm) tubulin alpha-2 chain 0.0917 0.5721 0.6909
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0057 0.0068
Onchocerca volvulus 0.0026 0.0033 0.0116
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0026 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0314 0.1872 0.2261
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0138 0.0167
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0026 0.0032
Brugia malayi follicle stimulating hormone receptor 0.0227 0.1314 0.1587
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0137 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0028 0.0028
Brugia malayi hypothetical protein 0.012 0.0634 0.0766
Brugia malayi Thioredoxin reductase 0.0046 0.0164 0.0198
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0037 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0028 0.0034
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0052 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0028 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0028 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0548 0.0662
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0028 0.0034
Brugia malayi hypothetical protein 0.007 0.0318 0.0384
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0029 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0028 0.0034
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0186 0.0194
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0033 0.004
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0029 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0166
Echinococcus multilocularis Polycystic kidney disease protein 0.0154 0.0852 0.0852
Echinococcus granulosus CREB binding protein 0.0198 0.113 0.1365
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0028 0.0034
Echinococcus granulosus agrin 0.0056 0.0225 0.0272
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0137 0.0137
Onchocerca volvulus 0.0056 0.0225 0.0796
Echinococcus granulosus tubulin alpha 3 chain 0.0917 0.5721 0.6909
Leishmania major beta tubulin 0.1319 0.828 1
Schistosoma mansoni tubulin subunit epsilon 0.0718 0.4446 0.537
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0026 0.5068
Echinococcus multilocularis tubulin alpha 3 chain 0.0917 0.5721 0.5721
Leishmania major beta tubulin 0.1319 0.828 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0794 0.0959
Brugia malayi hypothetical protein 0.032 0.1907 0.2304
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0225 0.0272
Brugia malayi Raf kinase 0.0042 0.0138 0.0167
Schistosoma mansoni tubulin subunit beta 0.0314 0.1872 0.2261
Leishmania major alpha tubulin 0.0917 0.5721 0.6909
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0028 0.0028
Echinococcus granulosus tubulin delta chain 0.0314 0.1872 0.2261
Entamoeba histolytica tubulin family protein 0.1319 0.828 1
Brugia malayi hypothetical protein 0.0154 0.0852 0.1029
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0052 0.0063
Trypanosoma cruzi MFS transporter, putative 0.0082 0.0391 0.0442
Schistosoma mansoni intermediate filament proteins 0.0026 0.0037 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0057 0.0068
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0137 0.0166
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0033 0.004
Echinococcus granulosus peroxisome assembly protein 26 0.0917 0.5721 0.6909
Echinococcus multilocularis lamin dm0 0.0026 0.0037 0.0037
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0033 0.004
Schistosoma mansoni cellular tumor antigen P53 0.0145 0.0794 0.0959
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0225
Plasmodium vivax tubulin beta chain, putative 0.1319 0.828 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0204 0.0246
Schistosoma mansoni tubulin subunit beta 0.1319 0.828 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0033 0.0033
Giardia lamblia Beta tubulin 0.1319 0.828 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0033 0.004
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0138 0.0138
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0186 0.0194
Brugia malayi sodium-independent organic anion transporter family protein 0.0082 0.0391 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0138 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0028 0.0034
Trypanosoma brucei alpha tubulin 0.0917 0.5721 0.6897
Brugia malayi MBOAT family protein 0.0026 0.0033 0.004
Onchocerca volvulus 0.0082 0.0391 0.1382
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0225 0.0272
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0052 0.0063
Echinococcus granulosus expressed protein 0.0734 0.4553 0.5498
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0033 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0548 0.0662
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0033 0.004
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0033 0.0008
Schistosoma mansoni single-minded 0.0095 0.0476 0.0575
Brugia malayi hypothetical protein 0.0154 0.0852 0.1029
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0137 0.0166
Trypanosoma brucei alpha tubulin 0.0917 0.5721 0.6897
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0164 0.0164
Brugia malayi Cytochrome P450 family protein 0.004 0.0121 0.0146
Trichomonas vaginalis tubulin beta chain, putative 0.0917 0.5721 0.6909
Echinococcus granulosus CREB binding protein 0.0032 0.0075 0.0091
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.043 0.0519
Brugia malayi PXA domain containing protein 0.0042 0.0137 0.0166
Brugia malayi hypothetical protein 0.0042 0.0137 0.0166
Leishmania major beta tubulin 0.1319 0.828 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.032 0.1907 0.2304
Echinococcus multilocularis tubulin alpha chain 0.0917 0.5721 0.5721
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0052 0.0063
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0033 0.004

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.46 uM Acyl coenzyme A:cholesterol acyltransferase (ACAT), inhibition by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from intestinal mucosa of cholesterol-fed rabbits ChEMBL. 8496932
IC50 (binding) = 2.46 uM Acyl coenzyme A:cholesterol acyltransferase (ACAT), inhibition by incubation with [1-14C]-oleolyl-CoA and intestinal microsomes isolated from intestinal mucosa of cholesterol-fed rabbits ChEMBL. 8496932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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