TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 554.683 | Formula: C32H38N6O3
H donors: 1 H acceptors: 4 LogP: 3.89 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCCC(=O)c1cnn(c1C)c1ccc(cc1)NC(=O)c1cn(c2c1cc(C)cc2)CC(=O)N1CCN(CC1)CC
InChi: 1S/C32H38N6O3/c1-5-7-30(39)27-19-33-38(23(27)4)25-11-9-24(10-12-25)34-32(41)28-20-37(29-13-8-22(3)18-26(28)29)21-31(40)36-16-14-35(6-2)15-17-36/h8-13,18-20H,5-7,14-17,21H2,1-4H3,(H,34,41)
InChiKey: QHXPIGIAJMEOJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purinergic receptor P2Y, G-protein coupled, 12	Starlite/ChEMBL	References
Rattus norvegicus	Purinergic receptor P2Y12	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Purinergic receptor P2Y12	343 aa	281 aa	22.8 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Purinergic receptor P2Y12	343 aa	328 aa	23.5 %
Schistosoma mansoni	neuropeptide receptor	Purinergic receptor P2Y12	343 aa	305 aa	24.9 %
Onchocerca volvulus		Purinergic receptor P2Y12	343 aa	323 aa	22.3 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Purinergic receptor P2Y12	343 aa	334 aa	21.6 %
Echinococcus multilocularis	allatostatin A receptor	Purinergic receptor P2Y12	343 aa	337 aa	21.4 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Purinergic receptor P2Y12	343 aa	372 aa	19.6 %
Echinococcus granulosus	neuropeptide receptor	Purinergic receptor P2Y12	343 aa	349 aa	22.6 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Purinergic receptor P2Y12	343 aa	347 aa	20.2 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Purinergic receptor P2Y12	343 aa	359 aa	20.9 %
Echinococcus granulosus	allatostatin A receptor	Purinergic receptor P2Y12	343 aa	337 aa	21.4 %
Schistosoma japonicum	Myosin-XVIIIa, putative	Purinergic receptor P2Y12	343 aa	325 aa	22.8 %
Echinococcus multilocularis	neuropeptide receptor	Purinergic receptor P2Y12	343 aa	325 aa	23.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0132	0.0269	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0187	0.0284
Schistosoma mansoni	hypothetical protein	0.015	0.0314	0.0361
Echinococcus multilocularis	Niemann Pick C1 protein	0.0364	0.0821	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.0013	0.0015
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	Notch2	0.0049	0.0073	0.011
Brugia malayi	protein C24B5.3	0.0022	0.0009	0.0013
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0163	0.0345	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Toxoplasma gondii	PAN domain-containing protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0411	0.0622
Plasmodium vivax	hypothetical protein, conserved	0.0132	0.0269	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0364	0.0821	0.1243
Plasmodium falciparum	kinesin-5	0.0549	0.1261	0.191
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0092	0.0139
Echinococcus granulosus	neuropeptide receptor A26	0.0333	0.0749	0.0749
Toxoplasma gondii	aldehyde dehydrogenase	0.0074	0.0131	0.0198
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2795	0.6601	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0057	0.0092	0.0092
Echinococcus multilocularis	neurogenic locus protein delta	0.0049	0.0073	0.0073
Echinococcus granulosus	transmembrane protease serine 3	0.0128	0.0261	0.0261
Brugia malayi	hypothetical protein	0.0692	0.1601	0.2425
Brugia malayi	beta-lactamase family protein	0.0132	0.0269	0.0407
Echinococcus multilocularis	neuropeptide s receptor	0.0333	0.0749	0.0749
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.2795	0.6601	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0029	0.0025	0.0025
Brugia malayi	latrophilin 2 splice variant baaae	0.021	0.0456	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.0013	0.0013
Echinococcus granulosus	Niemann Pick C1 protein	0.052	0.1192	0.1192
Echinococcus granulosus	protein jagged 2	0.0049	0.0073	0.0073
Echinococcus granulosus	tissue type plasminogen activator	0.0353	0.0796	0.0796
Plasmodium vivax	acyl-CoA synthetase, putative	0.0022	0.0007	0.0011
Schistosoma mansoni	sex comb on midleg homolog	0.0037	0.0044	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0014	0.0021
Entamoeba histolytica	hypothetical protein	0.0147	0.0305	0.0427
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0021	0.0007	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Onchocerca volvulus		0.0029	0.0025	0.0078
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0081	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0137	0.0208
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0029	0.0025	0.0025
Toxoplasma gondii	PAN domain-containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Schistosoma mansoni	smad	0.0024	0.0013	0.0015
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0029	0.0025	0.0025
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Toxoplasma gondii	kringle domain-containing protein	0.0353	0.0796	0.1206
Loa Loa (eye worm)	PAN domain-containing protein	0.0131	0.0267	0.0404
Trypanosoma cruzi	polo-like protein kinase, putative	0.0133	0.0272	0.0413
Giardia lamblia	High cysteine protein	0.0049	0.0073	0.0012
Echinococcus granulosus	glycine receptor subunit beta	0.0029	0.0025	0.0025
Echinococcus granulosus	slit 2 protein	0.0049	0.0073	0.0073
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.0353	0.0796	0.0916
Brugia malayi	Patched protein homolog 1	0.0022	0.0009	0.0013
Echinococcus granulosus	expressed conserved protein	0.0342	0.0768	0.0768
Onchocerca volvulus		0.0131	0.0267	0.1255
Brugia malayi	MH1 domain containing protein	0.0024	0.0013	0.0019
Mycobacterium leprae	conserved hypothetical protein	0.0132	0.0269	1
Schistosoma mansoni	kinase	0.0068	0.0117	0.0134
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2795	0.6601	1
Mycobacterium ulcerans	hypothetical protein	0.0132	0.0269	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0261	0.0395
Echinococcus granulosus	nAChR subunit	0.0029	0.0025	0.0025
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0141	0.0292	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0037
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0163	0.0345	0.0522
Schistosoma mansoni	lamin	0.0053	0.0081	0.0093
Echinococcus multilocularis	lamin dm0	0.0053	0.0081	0.0081
Brugia malayi	RNA, U transporter 1	0.0051	0.0077	0.0116
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0046	0.0065	0.0098
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0119	0.0239	0.0239
Echinococcus multilocularis	microtubule associated protein 2	0.0424	0.0964	0.0964
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.019	0.0408	0.0619
Echinococcus multilocularis	Tolloid protein 1	0.0115	0.023	0.023
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0046	0.0065	0.0098
Schistosoma mansoni	septate junction protein	0.0049	0.0073	0.0084
Trichomonas vaginalis	D-aminoacylase, putative	0.0132	0.0269	0.036
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0029	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0044	0.0067
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0029	0.0025	0.007
Echinococcus granulosus	protein jagged 1	0.0049	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0032	0.0048
Leishmania major	hypothetical protein, conserved	0.0132	0.0269	0.0407
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0135	0.0278	0.0278
Echinococcus granulosus	Niemann Pick C1 protein	0.0364	0.0821	0.0821
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0013	0.0015
Mycobacterium ulcerans	hypothetical protein	0.122	0.2857	1
Echinococcus multilocularis	protein jagged 2	0.0049	0.0073	0.0073
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	sex comb on midleg homolog	0.0037	0.0044	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	GPCR, family 2	0.0097	0.0187	0.0187
Echinococcus multilocularis	protein jagged 1	0.0049	0.0073	0.0073
Onchocerca volvulus		0.0131	0.0267	0.1255
Echinococcus granulosus	neurogenic locus notch protein 4	0.0049	0.0073	0.0073
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0049	0.0073	0.0311
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0369	0.0834	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Toxoplasma gondii	patched family protein	0.0022	0.0009	0.0013
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0019	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0128	0.0261	0.03
Schistosoma mansoni	hypothetical protein	0.0147	0.0305	0.0351
Brugia malayi	jmjC domain containing protein	0.0187	0.0401	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0261	0.0395
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0133	0.0272	0.0413
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0029	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0115	0.023	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Schistosoma mansoni	tar DNA-binding protein	0.0105	0.0206	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0042	0.0057	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0079	0.0119
Schistosoma mansoni	cell polarity protein	0.0049	0.0073	0.0084
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0128	0.0261	0.03
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0132	0.0269	0.0927
Brugia malayi	Muscle positioning protein 4	0.0049	0.0073	0.011
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0156	0.0327	0.0496
Brugia malayi	Kinesin motor domain containing protein	0.0549	0.1261	0.191
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0029	0.0025	0.0038
Onchocerca volvulus		0.0132	0.0269	0.1265
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0076	0.0137	0.0158
Brugia malayi	Kringle domain containing protein	0.0353	0.0796	0.1206
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0049	0.0073	0.011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Brugia malayi	exodeoxyribonuclease III family protein	0.0046	0.0065	0.0098
Schistosoma mansoni	microtubule-associated protein tau	0.0424	0.0964	0.1108
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0029	0.0025	0.0025
Loa Loa (eye worm)	PAN domain-containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	tar DNA-binding protein	0.0105	0.0206	0.0236
Echinococcus granulosus	Smad4	0.0024	0.0013	0.0013
Echinococcus granulosus	lysine specific demethylase 5A	0.0073	0.013	0.013
Mycobacterium ulcerans	hypothetical protein	0.0128	0.0261	0.089
Schistosoma mansoni	patched 1	0.0156	0.0327	0.0376
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0046	0.0065	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	PAN domain-containing protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	MH2 domain-containing protein	0.035	0.0787	0.1193
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0187	0.0401	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0105	0.0206	0.0311
Loa Loa (eye worm)	PAN domain-containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0029	0.0025	0.0038
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0841	0.1954	0.6835
Mycobacterium tuberculosis	Conserved protein	0.0132	0.0269	0.0927
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.002	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0261	0.0395
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0081	0.0123
Mycobacterium tuberculosis	Conserved protein	0.0132	0.0269	0.0927
Schistosoma mansoni	hypothetical protein	0.021	0.0456	0.0524
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0025	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0057	0.0086
Echinococcus granulosus	microtubule associated protein 2	0.0424	0.0964	0.0964
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Echinococcus granulosus	dnaJ subfamily B	0.063	0.1453	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0029	0.0025	0.0038
Brugia malayi	Protein kinase domain containing protein	0.0353	0.0796	0.1206
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0029	0.0025	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0128	0.0261	0.0261
Echinococcus granulosus	SAM and MBT domain containing protein	0.0037	0.0044	0.0044
Trichomonas vaginalis	penicillin-binding protein, putative	0.0132	0.0269	0.036
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0135	0.0278	0.0278
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.013	0.015
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0049	0.0073	0.0073
Brugia malayi	beta-lactamase	0.0132	0.0269	0.0407
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.03
Echinococcus multilocularis	jumonji domain containing protein	0.008	0.0145	0.0145
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0405	0.092	0.1393
Echinococcus granulosus	peregrin	0.0059	0.0096	0.0096
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0049	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Echinococcus multilocularis	expressed conserved protein	0.0342	0.0768	0.0768
Onchocerca volvulus		0.0076	0.0137	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0041	0.0062
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0032	0.0037
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0007	0.0011
Schistosoma mansoni	cpg binding protein	0.0044	0.0061	0.007
Echinococcus granulosus	neuropeptide s receptor	0.0333	0.0749	0.0749
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0046	0.0065	0.0098
Trypanosoma cruzi	hypothetical protein, conserved	0.0353	0.0796	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0025	0.0037
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0132	0.0269	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	protein C24B5.3	0.0022	0.0009	0.0013
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0094	0.0179	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Echinococcus multilocularis	transmembrane protease serine 3	0.0128	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0261	0.0395
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0074	0.0131	0.0443
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0046	0.0065	0.0098
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0023	0.0035
Entamoeba histolytica	hypothetical protein	0.0147	0.0305	0.0427
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0135	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0011
Onchocerca volvulus		0.0053	0.0081	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0011
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0022	0.001	0.001
Onchocerca volvulus	Alhambra homolog	0.0057	0.0092	0.0406
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0133	0.0272	0.0413
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.0025	0.0029
Loa Loa (eye worm)	TAR-binding protein	0.0105	0.0206	0.0311
Toxoplasma gondii	PAN domain-containing protein	0.0131	0.0267	0.0404
Onchocerca volvulus	Putative nachr subunit	0.0076	0.0137	0.0625
Onchocerca volvulus		0.0128	0.0261	0.1226
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0137	0.0137
Schistosoma mansoni	hypothetical protein	0.0102	0.0197	0.0227
Toxoplasma gondii	PAN domain-containing protein	0.0451	0.1029	0.1559
Trichomonas vaginalis	ap endonuclease, putative	0.0046	0.0065	0.005
Onchocerca volvulus		0.0888	0.2067	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0025	0.0037
Onchocerca volvulus		0.0076	0.0137	0.0625
Brugia malayi	Latrophilin receptor protein 2	0.0097	0.0187	0.0284
Schistosoma mansoni	aldehyde dehydrogenase	0.0074	0.0131	0.0151
Onchocerca volvulus		0.0132	0.0269	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus multilocularis	neuropeptide receptor A26	0.0333	0.0749	0.0749
Loa Loa (eye worm)	patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0278	0.0421
Onchocerca volvulus		0.0044	0.0061	0.0256
Schistosoma mansoni	hypothetical protein	0.0097	0.0187	0.0216
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0029	0.0025	0.007
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0025	0.0037
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Trypanosoma cruzi	hypothetical protein, conserved	0.0132	0.0269	0.0407
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0029	0.0025	0.0061
Loa Loa (eye worm)	Smad1	0.0024	0.0013	0.0019
Brugia malayi	Patched related family protein 10	0.0022	0.0009	0.0013
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0156	0.0327	0.0496
Brugia malayi	MH1 domain containing protein	0.0024	0.0013	0.0019
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.03
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0327	0.0496
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.0013	0.0019
Loa Loa (eye worm)	transcription factor SMAD2	0.035	0.0787	0.1193
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0115	0.023	0.0264
Echinococcus multilocularis		0.2795	0.6601	0.6601
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0132	0.0269	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0016	0.0025
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0086	0.016	0.0242
Echinococcus granulosus	protein jagged 1	0.0049	0.0073	0.0073
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0113	0.0122
Brugia malayi	PHD-finger family protein	0.0057	0.0092	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Trypanosoma cruzi	hypothetical protein, conserved	0.0132	0.0269	0.0407
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Brugia malayi	Calcium binding EGF domain containing protein	0.0049	0.0073	0.011
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0022	0.001	0.001
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Schistosoma mansoni	kinesin eg-5	0.0549	0.1261	0.145
Brugia malayi	hypothetical protein	0.0147	0.0305	0.0463
Echinococcus granulosus	glycine receptor subunit beta	0.0029	0.0025	0.0025
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0119	0.0239	0.0361
Loa Loa (eye worm)	trypsin family protein	0.0128	0.0261	0.0395
Schistosoma mansoni	cellular tumor antigen P53	0.0097	0.0187	0.0215
Brugia malayi	Myosin head containing protein	0.0022	0.0009	0.0013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0163	0.0345	0.0396
Brugia malayi	jmjC domain containing protein	0.0073	0.013	0.0197
Leishmania major	hypothetical protein, conserved	0.0353	0.0796	0.1206
Schistosoma mansoni	aldehyde dehydrogenase	0.0074	0.0131	0.0151
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.0025	0.0038
Mycobacterium tuberculosis	Probable hydrolase	0.0132	0.0269	0.0927
Brugia malayi	Calcium binding EGF domain containing protein	0.0049	0.0073	0.011
Loa Loa (eye worm)	patched family protein	0.0022	0.0009	0.0013
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0032	0.0032	0.0012
Mycobacterium tuberculosis	Conserved protein	0.0132	0.0269	0.0927
Onchocerca volvulus	Slit protein homolog	0.0049	0.0073	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus granulosus	GPCR family 2	0.0097	0.0187	0.0187
Onchocerca volvulus		0.0049	0.0073	0.0311
Schistosoma mansoni	Smad4	0.0024	0.0013	0.0015
Onchocerca volvulus		0.0131	0.0267	0.1255
Echinococcus multilocularis	fibropellin Ia	0.0049	0.0073	0.0073
Onchocerca volvulus		0.0128	0.0261	0.1226
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0187	0.0401	0.0401
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0076	0.0137	0.0208
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0115	0.023	0.0348
Brugia malayi	Inositol-1	0.0032	0.0032	0.0049
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.0013	0.0019
Schistosoma mansoni	laminin gamma-3 chain	0.0049	0.0073	0.0084
Brugia malayi	MH2 domain containing protein	0.0024	0.0013	0.0019
Echinococcus multilocularis	tar DNA binding protein	0.0105	0.0206	0.0206
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0029	0.0025	0.0025
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.2795	0.6601	0.7592
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus multilocularis	inositol monophosphatase 1	0.0032	0.0032	0.0032
Schistosoma mansoni	bromodomain containing protein	0.0052	0.0079	0.0091
Echinococcus multilocularis	geminin	0.0102	0.0197	0.0197
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0115	0.023	0.0348
Onchocerca volvulus		0.0097	0.0187	0.0866
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0132	0.0269	0.0269
Toxoplasma gondii	PAN domain-containing protein	0.0451	0.1029	0.1559
Loa Loa (eye worm)	patched family protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.0131	0.0267	0.1255
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0156	0.0326	0.0326
Brugia malayi	Bromodomain containing protein	0.003	0.0027	0.0041
Brugia malayi	mbt repeat family protein	0.0037	0.0044	0.0067
Loa Loa (eye worm)	ACC-1 protein	0.0029	0.0025	0.0038
Onchocerca volvulus		0.0029	0.0025	0.0081
Brugia malayi	intermediate filament protein	0.0053	0.0081	0.0123
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0032	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.0076	0.0137	0.0625
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0405	0.092	0.1393
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0022	0.0007	0.001
Brugia malayi	hypothetical protein	0.0128	0.0261	0.0395
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0001	0.0001
Loa Loa (eye worm)	LGC-31 protein	0.0029	0.0025	0.0038
Onchocerca volvulus		0.0353	0.0796	0.3828
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Brugia malayi	hypothetical protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.076	0.1762	0.8519
Brugia malayi	Bromodomain containing protein	0.0059	0.0096	0.0146
Loa Loa (eye worm)	hypothetical protein	0.021	0.0456	0.0691
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0025	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0076	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0137	0.0208
Echinococcus granulosus	survival motor neuron protein 1	0.0692	0.1601	0.1601
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0888	0.2067	0.2377
Brugia malayi	CHE-14 protein	0.0156	0.0327	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0132	0.0269	0.036
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0029	0.0025	0.0038
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0076	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.0272	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0011
Brugia malayi	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	PHD-finger family protein	0.0022	0.0008	0.0013
Schistosoma mansoni	jumonji domain containing protein	0.0149	0.031	0.0356
Brugia malayi	beta-lactamase family protein	0.0132	0.0269	0.0407
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Onchocerca volvulus		0.0128	0.0261	0.1226
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0029	0.0025	0.0061
Toxoplasma gondii	patched family protein	0.0022	0.0009	0.0013
Brugia malayi	Trypsin-like protease protein 5	0.0128	0.0261	0.0395
Echinococcus multilocularis	glycine receptor subunit beta	0.0029	0.0025	0.0025
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0308	0.0687	0.1041
Trichomonas vaginalis	esterase, putative	0.0132	0.0269	0.036
Brugia malayi	Niemann-Pick C1 protein precursor	0.0364	0.0821	0.1243
Onchocerca volvulus		0.0053	0.0081	0.0353
Echinococcus multilocularis	glycoprotein Antigen 5	0.0128	0.0261	0.0261
Toxoplasma gondii	EGF family domain-containing protein	0.0049	0.0073	0.011
Brugia malayi	Smad1	0.0024	0.0013	0.0019
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0129	0.0264	0.0264
Echinococcus multilocularis	tumor protein p63	0.0663	0.1532	0.1532
Echinococcus multilocularis	slit 2 protein	0.0049	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0133	0.0272	0.1281
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0092	0.0139
Brugia malayi	Patched related family protein 12	0.0022	0.0009	0.0013
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0308	0.0687	0.1041
Toxoplasma gondii	PAN domain-containing protein	0.0131	0.0267	0.0404
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0057	0.0092	0.0106
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	inositol-1	0.0032	0.0032	0.0049
Mycobacterium tuberculosis	Probable lipase LipE	0.0132	0.0269	0.0927
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0087	0.0132
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0888	0.2067	0.2377
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Loa Loa (eye worm)	STAT protein	0.0156	0.0327	0.0496
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Brugia malayi	Patched related family protein 4	0.0022	0.0009	0.0013
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0081	0.0123
Brugia malayi	protein-S isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0156	0.0327	0.0327
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0132	0.0269	0.0309
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Schistosoma mansoni	hypothetical protein	0.063	0.1453	0.1671
Schistosoma mansoni	amidase	0.0129	0.0264	0.0303
Schistosoma mansoni	cpg binding protein	0.0048	0.0071	0.0081
Echinococcus multilocularis	notch	0.0049	0.0073	0.0073
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.2795	0.6601	1
Echinococcus multilocularis	nAChR subunit	0.0029	0.0025	0.0025
Brugia malayi	Trypsin family protein	0.0128	0.0261	0.0395
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.0025	0.0038
Toxoplasma gondii	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.013	0.0197
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0147	0.0305	0.0305
Toxoplasma gondii	microneme protein MIC4	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus granulosus	notch	0.0049	0.0073	0.0073
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0133	0.0272	0.0272
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0131	0.0267	0.0404
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0128	0.0261	0.0261
Echinococcus multilocularis	protein patched	0.0156	0.0327	0.0327
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Brugia malayi	notch-like transmembrane receptor	0.0049	0.0073	0.011
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Echinococcus multilocularis	Smad4	0.0024	0.0013	0.0013
Onchocerca volvulus		0.0049	0.0073	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	Calcium binding EGF domain containing protein	0.0115	0.023	0.0348
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	cpg binding protein	0.0048	0.0071	0.0081
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0129	0.0264	0.0264
Onchocerca volvulus		0.0049	0.0073	0.0311
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0023	0.0035
Echinococcus granulosus	tumor protein p63	0.0663	0.1532	0.1532
Echinococcus granulosus	intermediate filament protein	0.0053	0.0081	0.0081
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.03
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Echinococcus multilocularis	protein jagged 1	0.0049	0.0073	0.0073
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.0013	0.0013
Toxoplasma gondii	subtilisin SUB12	0.0131	0.0267	0.0404
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0132	0.0269	0.0927
Mycobacterium ulcerans	beta-lactamase	0.0132	0.0269	0.0918
Schistosoma mansoni	hypothetical protein	0.0057	0.0092	0.0106
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0261	0.0395
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0097	0.0187	0.0284
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0163	0.0345	0.0345
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.0132	0.0269	0.1265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0163	0.0345	0.0396
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0097	0.0187	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Schistosoma mansoni	hypothetical protein	0.0097	0.0187	0.0216
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0081	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Echinococcus multilocularis	Niemann Pick C1 protein	0.052	0.1192	0.1192
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0029	0.0025	0.0038
Onchocerca volvulus		0.0131	0.0267	0.1255
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0029	0.0025	0.0025
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0076	0.0137	0.0158
Brugia malayi	mbt repeat family protein	0.0037	0.0044	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	tissue type plasminogen activator	0.0353	0.0796	0.0796
Toxoplasma gondii	microneme protein MIC17B	0.0131	0.0267	0.0404
Schistosoma mansoni	hypothetical protein	0.0097	0.0187	0.0216
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Brugia malayi	Cadherin domain containing protein	0.0049	0.0073	0.011
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0137	0.0208
Brugia malayi	MH2 domain containing protein	0.035	0.0787	0.1193
Echinococcus granulosus	polycomb protein SCMH1	0.0037	0.0044	0.0044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Brugia malayi	Cation transporter family protein	0.0029	0.0025	0.0038
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.2795	0.6601	1
Echinococcus granulosus	Mastin	0.0128	0.0261	0.0261
Schistosoma mansoni	tar DNA-binding protein	0.0105	0.0206	0.0236
Echinococcus multilocularis	polycomb protein SCMH1	0.0037	0.0044	0.0044
Loa Loa (eye worm)	jmjC domain-containing protein	0.0118	0.0237	0.0359
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0049	0.0073	0.0084
Plasmodium falciparum	phd finger protein, putative	0.0057	0.0092	0.0139
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0032	0.0049
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0028	0.0023	0.0023
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0074	0.0131	0.0131
Echinococcus granulosus	delta-like protein 1	0.0049	0.0073	0.0073
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0135	0.0278	0.0421
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.003	0.0027	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0888	0.2067	0.3131
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2795	0.6601	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Entamoeba histolytica	hypothetical protein	0.0147	0.0305	0.0427
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0029	0.0025	0.0025
Loa Loa (eye worm)	patched family protein	0.0022	0.0009	0.0013
Schistosoma mansoni	survival motor neuron protein	0.0141	0.0292	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0187	0.0283
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0364	0.0821	0.1211
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0156	0.0326	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Echinococcus granulosus	laminin	0.0115	0.023	0.023
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0037	0.0044	0.0051
Trichomonas vaginalis	D-aminoacylase, putative	0.0132	0.0269	0.036
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0115	0.023	0.0348
Giardia lamblia	Kinase, PLK	0.0133	0.0272	0.0317
Mycobacterium ulcerans	lipase LipD	0.0132	0.0269	0.0918
Toxoplasma gondii	hypothetical protein	0.0131	0.0267	0.0404
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Schistosoma mansoni	egf-like domain protein	0.0115	0.023	0.0264
Brugia malayi	F/Y-rich N-terminus family protein	0.0034	0.0036	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0115	0.023	0.0348
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0128	0.0261	0.0261
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0037	0.0044	0.0175
Trypanosoma brucei	polo-like protein kinase	0.0133	0.0272	0.0413
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.2795	0.6601	1
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0074	0.0131	0.0131
Echinococcus multilocularis	smad	0.0024	0.0013	0.0013
Mycobacterium ulcerans	hypothetical protein	0.0029	0.0025	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0046	0.0065	0.0065
Trypanosoma cruzi	polo-like protein kinase, putative	0.0133	0.0272	0.0413
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0195	0.042	0.042
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0129	0.0264	0.0264
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0046	0.0065	0.0098
Onchocerca volvulus		0.0131	0.0267	0.1255
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	glycine receptor subunit beta	0.0029	0.0025	0.0025
Schistosoma mansoni	hypothetical protein	0.015	0.0314	0.0361
Entamoeba histolytica	hypothetical protein	0.0147	0.0305	0.0427
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0132	0.0269	0.0309
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0074	0.0131	0.0434
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0025	0.0037
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0097	0.0187	0.0187
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Onchocerca volvulus		0.0131	0.0267	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0011
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0042	0.0057	0.0057
Loa Loa (eye worm)	PHD-finger family protein	0.0057	0.0092	0.0139
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0163	0.0345	0.0345
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2795	0.6601	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0692	0.1601	0.1601
Echinococcus multilocularis	neurogenic locus protein delta	0.0049	0.0073	0.0073
Echinococcus multilocularis	cpg binding protein	0.0048	0.0071	0.0071
Echinococcus multilocularis	sterol regulatory element binding protein	0.0156	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0137	0.0208
Plasmodium falciparum	acyl-CoA synthetase	0.0022	0.0007	0.0011
Brugia malayi	GCC2 and GCC3 family protein	0.0049	0.0073	0.011
Onchocerca volvulus		0.0128	0.0261	0.1226
Loa Loa (eye worm)	TK/ROR protein kinase	0.0353	0.0796	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Loa Loa (eye worm)	hypothetical protein	0.0115	0.023	0.0348
Echinococcus granulosus	glycoprotein Antigen 5	0.0128	0.0261	0.0261
Echinococcus granulosus	smad	0.0024	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0129	0.0264	0.0264
Echinococcus granulosus	tar DNA binding protein	0.0105	0.0206	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0025	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus granulosus	beta LACTamase domain containing family member	0.0132	0.0269	0.0269
Echinococcus multilocularis	dnaJ subfamily B	0.063	0.1453	0.1453
Toxoplasma gondii	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	snurportin 1	0.019	0.0408	0.0408
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0353	0.0796	0.1206
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0032	0.0049
Plasmodium vivax	kinesin-5	0.0549	0.1261	0.191
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0029	0.0025	0.0014
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Echinococcus multilocularis	protein dispatched 1	0.0178	0.038	0.038
Plasmodium falciparum	cysteine repeat modular protein 1	0.0353	0.0796	0.1206
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0025	0.0061
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0029	0.0025	0.0038
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.2795	0.6601	1
Trichomonas vaginalis	ap endonuclease, putative	0.0046	0.0065	0.005
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0135	0.0278	0.0319
Schistosoma mansoni	hypothetical protein	0.015	0.0314	0.0361
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0029	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus granulosus	histone acetyltransferase MYST2	0.0042	0.0057	0.0057
Echinococcus multilocularis	laminin	0.0115	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Toxoplasma gondii	patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0888	0.2067	0.3131
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.3698	0.8747	0.8747
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0115	0.023	0.0348
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0044	0.0061	0.0093
Brugia malayi	Calcium binding EGF domain containing protein	0.0049	0.0073	0.011
Echinococcus multilocularis	kinesin family 1	0.4225	1	1
Loa Loa (eye worm)	mbt repeat family protein	0.0037	0.0044	0.0067
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Mycobacterium leprae	Probable lipase LipE	0.0132	0.0269	1
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0113	0.0122
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0029	0.0025	0.0038
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0029	0.0025	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0267	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0135	0.0278	0.0278
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0076	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Onchocerca volvulus		0.0029	0.0025	0.0081
Toxoplasma gondii	microneme protein MIC17A	0.0131	0.0267	0.0404
Schistosoma mansoni	hypothetical protein	0.0141	0.0292	0.0335
Onchocerca volvulus		0.0029	0.0025	0.0081
Echinococcus granulosus	fetal alzheimer antigen falz	0.002	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0115	0.023	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Onchocerca volvulus	Arrow homolog	0.0115	0.023	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Brugia malayi	hypothetical protein	0.0022	0.0009	0.0013
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.03
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.122	0.2857	1
Trichomonas vaginalis	conserved hypothetical protein	0.0156	0.0327	0.0449
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0046	0.0065	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0032	0.0032	0.0087
Toxoplasma gondii	kinesin motor domain-containing protein	0.0549	0.1261	0.191
Onchocerca volvulus		0.0131	0.0267	0.1255
Schistosoma mansoni	fatty-acid amide hydrolase	0.0129	0.0264	0.0303
Schistosoma mansoni	hypothetical protein	0.015	0.0314	0.0361
Giardia lamblia	PHD finger protein 15	0.0057	0.0092	0.0042
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.2795	0.6601	0.6601
Schistosoma mansoni	hypothetical protein	0.0235	0.0515	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0353	0.0796	0.1206
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Schistosoma mansoni	ap endonuclease	0.0046	0.0065	0.0075
Brugia malayi	RNA binding protein	0.0105	0.0206	0.0311
Brugia malayi	Fibulin-1 precursor	0.0115	0.023	0.0348
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0022	0.0007	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0074	0.0131	0.0434
Brugia malayi	RNA recognition motif domain containing protein	0.0105	0.0206	0.0311
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0046	0.0065	0.0061
Echinococcus multilocularis	neurogenic locus notch protein	0.0049	0.0073	0.0073
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0097	0.0187	0.0187
Schistosoma mansoni	hypothetical protein	0.0049	0.0073	0.0084
Onchocerca volvulus		0.0141	0.0292	0.1375
Echinococcus granulosus	jumonji domain containing protein	0.008	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Mycobacterium tuberculosis	Probable lipase LipD	0.0132	0.0269	0.0927
Toxoplasma gondii	microneme protein, putative	0.0131	0.0267	0.0404
Echinococcus multilocularis	peregrin	0.0059	0.0096	0.0096
Schistosoma mansoni	slit	0.0049	0.0073	0.0084
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0132	0.0269	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0025	0.0016	0.0016
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0074	0.0131	0.0434
Schistosoma mansoni	hypothetical protein	0.0097	0.0187	0.0216
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.002	0.0004	0.0004
Echinococcus granulosus	neural cadherin	0.0049	0.0073	0.0073
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0133	0.0272	0.0272
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.03
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Toxoplasma gondii	ABC1 family protein	0.0132	0.0269	0.0407
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0147	0.0305	0.0305
Onchocerca volvulus		0.0131	0.0267	0.1255
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0081	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Schistosoma mansoni	transcription factor LCR-F1	0.0147	0.0305	0.0351
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.0049	0.0073	0.0311
Echinococcus granulosus	lamin dm0	0.0053	0.0081	0.0081
Brugia malayi	excitatory GABA receptor EXP-1A	0.0029	0.0025	0.0038
Echinococcus multilocularis	neurogenic locus notch protein	0.0049	0.0073	0.0073
Onchocerca volvulus		0.0128	0.0261	0.1226
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0029	0.0025	0.0061
Entamoeba histolytica	kinesin, putative	0.0549	0.1261	0.188
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	Mastin	0.0128	0.0261	0.0261
Brugia malayi	Cation transporter family protein	0.0076	0.0137	0.0208
Toxoplasma gondii	microneme protein MIC17C	0.0131	0.0267	0.0404
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Schistosoma mansoni	notch	0.0049	0.0073	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Schistosoma mansoni	hypothetical protein	0.0019	0.0001	0.0001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0029	0.0025	0.0061
Leishmania major	4-coumarate:coa ligase-like protein	0.0029	0.0025	0.0037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0163	0.0345	0.0345
Brugia malayi	AF-10 protein	0.0019	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0189	0.0287
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0131	0.0267	0.0404
Echinococcus granulosus	lamin	0.0053	0.0081	0.0081
Mycobacterium tuberculosis	Probable esterase LipL	0.0132	0.0269	0.0927
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	ACC-1 protein	0.0029	0.0025	0.0038
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0029	0.0025	0.0014
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0074	0.0131	0.0198
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0128	0.0261	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0264	0.04
Onchocerca volvulus		0.0131	0.0267	0.1255
Brugia malayi	MH2 domain containing protein	0.0024	0.0013	0.0019
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0029	0.0025	0.0038
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0092	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0692	0.1601	0.2425
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Echinococcus granulosus	inositol monophosphatase 1	0.0032	0.0032	0.0032
Loa Loa (eye worm)	notch protein	0.0049	0.0073	0.011
Brugia malayi	Cadherin domain containing protein	0.0049	0.0073	0.011
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0042	0.0057	0.0065
Echinococcus granulosus	cpg binding protein	0.0048	0.0071	0.0071
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0115	0.023	0.0348
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0115	0.023	0.0348
Brugia malayi	Bromodomain containing protein	0.0061	0.0101	0.0153
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Loa Loa (eye worm)	hypothetical protein	0.003	0.0027	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Onchocerca volvulus		0.0037	0.0044	0.0175
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.013	0.015
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0115	0.023	0.0348
Echinococcus granulosus	protein jagged 2	0.0049	0.0073	0.0073
Trypanosoma brucei	hypothetical protein, conserved	0.0132	0.0269	0.0407
Schistosoma mansoni	ap endonuclease	0.0046	0.0065	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0269	0.0407
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Brugia malayi	serine/threonine-protein kinase plk-2	0.0133	0.0272	0.0413
Loa Loa (eye worm)	MBCTL1	0.0042	0.0057	0.0086
Echinococcus granulosus	neurogenic locus protein delta	0.0049	0.0073	0.0073
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2795	0.6601	1
Echinococcus granulosus	neurogenic locus notch protein	0.0049	0.0073	0.0073
Brugia malayi	Trypsin family protein	0.0128	0.0261	0.0395
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0037	0.0044	0.0044
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.0025	0.0029
Brugia malayi	TAR-binding protein	0.0105	0.0206	0.0311
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0029	0.0025	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Echinococcus granulosus	neurogenic locus notch protein	0.0049	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0028	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0025	0.0038
Mycobacterium ulcerans	esterase/lipase LipP	0.0132	0.0269	0.0918
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Echinococcus multilocularis	neural cadherin	0.0049	0.0073	0.0073
Onchocerca volvulus	Neurogenic locus notch homolog	0.0049	0.0073	0.0311
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0046	0.0065	0.0098
Onchocerca volvulus		0.0131	0.0267	0.1255
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0119	0.0239	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0014	0.0021
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0046	0.0065	0.0212
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0076	0.0137	0.0137
Schistosoma mansoni	tar DNA-binding protein	0.0105	0.0206	0.0236
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0046	0.0065	0.0098
Schistosoma mansoni	cercarial elastase (S01 family)	0.0128	0.0261	0.03
Loa Loa (eye worm)	PAN domain-containing protein	0.0131	0.0267	0.0404
Echinococcus granulosus	Tolloid protein 1	0.0115	0.023	0.023
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Toxoplasma gondii	exonuclease III APE	0.0046	0.0065	0.0098
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0049	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.0102	0.0197	0.0227
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0046	0.0065	0.0202
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0042	0.0057	0.0057
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0128	0.0261	0.0261
Echinococcus multilocularis	fibrillin 1	0.0115	0.023	0.023
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0092	0.0139
Brugia malayi	Trypsin family protein	0.0128	0.0261	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0013	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0105	0.016
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Echinococcus granulosus	geminin	0.0102	0.0197	0.0197
Echinococcus granulosus	snurportin 1	0.019	0.0408	0.0408
Onchocerca volvulus		0.0049	0.0073	0.0311
Echinococcus multilocularis	musashi	0.0053	0.0081	0.0081
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0029	0.0025	0.0025
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.0013	0.0013
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0029	0.0024	0.0069
Echinococcus granulosus	Protein patched homolog 1	0.0156	0.0327	0.0327
Trichomonas vaginalis	CAMK family protein kinase	0.0133	0.0272	0.0366
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Brugia malayi	Patched family protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	beta-lactamase	0.0132	0.0269	0.0407
Brugia malayi	PHD-finger family protein	0.0023	0.001	0.0015
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0049	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0073	0.011
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0549	0.1261	0.191
Brugia malayi	EGF-like domain containing protein	0.0049	0.0073	0.011
Brugia malayi	amidase	0.0129	0.0264	0.04
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0195	0.042	0.042
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0119	0.0239	0.0361
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0133	0.0272	0.0377
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0013	0.0015
Schistosoma mansoni	tar DNA-binding protein	0.0105	0.0206	0.0236
Brugia malayi	CXXC zinc finger family protein	0.0044	0.0061	0.0093
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0042	0.0057	0.0057
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0029	0.0025	0.0038
Brugia malayi	Delta serrate ligand family protein	0.0049	0.0073	0.011
Echinococcus multilocularis	lamin	0.0053	0.0081	0.0081
Echinococcus multilocularis	enteropeptidase	0.0128	0.0261	0.0261
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0163	0.0345	0.0345
Schistosoma mansoni	nAChR subunit	0.0029	0.0025	0.0029
Onchocerca volvulus	Putative cubilin	0.0049	0.0073	0.0311
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0029	0.0025	0.0038
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0032	0.0049
Echinococcus granulosus	fibropellin Ia	0.0049	0.0073	0.0073
Echinococcus granulosus	enteropeptidase	0.0128	0.0261	0.0261
Trichomonas vaginalis	D-aminoacylase, putative	0.0132	0.0269	0.036
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0135	0.0278	0.0326
Brugia malayi	PAN domain containing protein	0.0131	0.0267	0.0404
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0032	0.0037
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0029	0.0025	0.0038
Loa Loa (eye worm)	RNA binding protein	0.0105	0.0206	0.0311
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0032	0.0032	0.0049
Schistosoma mansoni	lamin	0.0053	0.0081	0.0093
Plasmodium falciparum	lipid/sterol:H+ symporter	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0029	0.0025	0.0025
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0076	0.0137	0.0137
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0163	0.0345	0.0396
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0046	0.0065	0.0065
Schistosoma mansoni	hypothetical protein	0.0128	0.0261	0.03
Brugia malayi	Trypsin family protein	0.0888	0.2067	0.3131
Schistosoma mansoni	hypothetical protein	0.019	0.0408	0.047
Giardia lamblia	Kinesin-5	0.0549	0.1261	0.183
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.0015
Echinococcus multilocularis	lysine specific demethylase 5A	0.0069	0.0121	0.0121
Brugia malayi	Cation transporter family protein	0.0029	0.0025	0.0038
Toxoplasma gondii	patched family protein	0.0022	0.0009	0.0013
Plasmodium vivax	patched family protein, putative	0.0022	0.0009	0.0013
Schistosoma mansoni	hypothetical protein	0.3676	0.8695	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0057	0.0092	0.0092
Loa Loa (eye worm)	patched family protein	0.0022	0.0009	0.0013

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 66 nM	Displacement of [33P]2MeS-ADP from P2Y12 receptor (unknown origin) transfected in CHO cells after 30 mins by scintillation counting analysis	ChEMBL.	25075638
IC50 (binding)	= 0.9 uM	Antagonist activity at P2Y12 receptor in Sprague-Dawley rat platelet rich plasma assessed as inhibition of ADP-induced aggregation	ChEMBL.	25075638

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3325657

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 925683