Detailed information for compound 934491

Basic information

Technical information
  • TDR Targets ID: 934491
  • Name: (2R,3R,4S,5R)-2-[7-(cyclobutylamino)imidazo[5 ,4-b]pyridin-3-yl]-5-(hydroxymethyl)oxolane-3 ,4-diol
  • MW: 320.344 | Formula: C15H20N4O4
  • H donors: 4 H acceptors: 5 LogP: -0.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nccc2NC1CCC1
  • InChi: 1S/C15H20N4O4/c20-6-10-12(21)13(22)15(23-10)19-7-17-11-9(4-5-16-14(11)19)18-8-2-1-3-8/h4-5,7-8,10,12-13,15,20-22H,1-3,6H2,(H,16,18)/t10-,12-,13-,15-/m1/s1
  • InChiKey: BFAZOYNYIUQLKY-BPGGGUHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5R)-2-[7-(cyclobutylamino)imidazo[5,4-b]pyridin-3-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[7-(cyclobutylamino)-3-imidazo[5,4-b]pyridinyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-[7-(cyclobutylamino)imidazo[5,4-b]pyridin-3-yl]-5-methylol-tetrahydrofuran-3,4-diol
  • AIDS-043003
  • AIDS043003
  • N(6)-cBu-1-deaza-A
  • N(6)-cyclobutyl-1-deazaadenosine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References
Rattus norvegicus Adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 274 aa 22.6 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 286 aa 26.9 %
Schistosoma mansoni dro/myosuppressin receptor Adenosine A1 receptor   326 aa 326 aa 22.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 327 aa 24.8 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 323 aa 20.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 304 aa 21.1 %
Echinococcus multilocularis neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Echinococcus granulosus neuropeptide receptor Adenosine A1 receptor   326 aa 299 aa 22.4 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 317 aa 24.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 305 aa 21.0 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 306 aa 21.2 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 300 aa 24.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Schistosoma japonicum Alpha-1A adrenergic receptor, putative Adenosine A1 receptor   326 aa 295 aa 28.1 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 311 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0079 0.0079
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0327 0.0762 0.5662
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0364 0.3224
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0099 0.0203 0.3498
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0099 0.0203 0.0203
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0327 0.0762 0.1984
Brugia malayi neuropeptide F receptor 0.0057 0.0098 0.0256
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0564 0.1345 0.3505
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.0503
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.0098 0.0098
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0034 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni thyroid hormone receptor 0.003 0.0034 0.0047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0098 0.0098
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0079 0.049
Mycobacterium ulcerans glutaminase 0.0266 0.0612 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0098 0.0146
Brugia malayi glutathione reductase 0.0048 0.0078 0.0202
Echinococcus multilocularis serotonin receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi Bromodomain containing protein 0.0029 0.0029 0.0076
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.0098 0.0098
Brugia malayi nuclear receptor NHR-88 0.003 0.0034 0.0087
Loa Loa (eye worm) hypothetical protein 0.0037 0.005 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0098 0.0098
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.163 0.3962 0.3962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.007 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.058 0.7616
Brugia malayi Thioredoxin reductase 0.0048 0.0078 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0078 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0204 0.046 0.1185
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0253 0.058 0.058
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0074 0.0104
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0133
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0034 0.0047
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0034 0.0042 0.0042
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0057 0.0098 0.0146
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0158 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0087 0.0645
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0066 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0034 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0564 0.1345 0.3505
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0067
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.079 0.19 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.0098 0.0138
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0327 0.0762 0.5662
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0449 0.0449
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.023 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0253 0.058 0.058
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.0346
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0612
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0034 0.0034
Giardia lamblia GTOR 0.0327 0.0762 0.4009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.007 0.007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.0098 0.0256
Brugia malayi Dopamine receptor protein 1 0.0538 0.1282 0.3339
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Leishmania major phosphatidylinositol 3-kinase, putative 0.0327 0.0762 0.2072
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Trypanosoma brucei glucosidase, putative 0.0036 0.0047 0.0347
Brugia malayi hypothetical protein 0.0453 0.1071 0.2789
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.0098 0.0098
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0034 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0762 0.1984
Trypanosoma brucei unspecified product 0.0019 0.0006 0.0043
Echinococcus granulosus somatostatin receptor 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.0098 0.0146
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0087 0.0087
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0034 0.0034
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0034 0.0034
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0078 0.2985
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni hypothetical protein 0.0048 0.0076 0.0106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni lozenge 0.0057 0.0098 0.0138
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.023 0.4693
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Brugia malayi putative neuropeptide receptor 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0057 0.0149
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0047 0.0121
Onchocerca volvulus 0.0081 0.0158 0.1251
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0253 0.058 0.0813
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.0098 0.0256
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0222 0.0505 0.3751
Leishmania major hypothetical protein, conserved 0.1513 0.3676 1
Brugia malayi intermediate filament protein 0.0081 0.0158 0.0412
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0327 0.0762 0.1972
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.0576 0.0896
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.026 1
Schistosoma mansoni microtubule-associated protein tau 0.1392 0.3379 0.4733
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.0098 0.0138
Toxoplasma gondii FATC domain-containing protein 0.0204 0.046 0.6039
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0098 0.0098
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0051 1
Echinococcus granulosus tm gpcr rhodopsin 0.0206 0.0466 0.0466
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.0015
Echinococcus multilocularis Zinc finger, PHD finger 0.0253 0.058 0.058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0323 0.0753 0.1174
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Brugia malayi RNA binding protein 0.0323 0.0753 0.1962
Echinococcus multilocularis neuropeptide receptor 0.0057 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Giardia lamblia Hypothetical protein 0.0099 0.0203 0.1068
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0034 0.0034
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0087 0.0127
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1579 0.3838 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0154 0.0233
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.0098 0.0098
Brugia malayi RE15519p 0.0057 0.0098 0.0256
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0034 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0047 0.0121
Schistosoma mansoni hypothetical protein 0.0123 0.0261 0.0365
Echinococcus granulosus microtubule associated protein 2 0.1392 0.3379 0.3379
Trypanosoma brucei trypanothione reductase 0.0048 0.0078 0.0577
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0037
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.0098 0.0146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Onchocerca volvulus 0.0057 0.0098 0.068
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0003 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0034 0.0087
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0253 0.058 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Onchocerca volvulus 0.0048 0.0076 0.0464
Brugia malayi CXXC zinc finger family protein 0.0028 0.0027 0.0072
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0027 0.0034
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0034 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0098 0.0146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0034 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0034 0.0044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0051 0.0269
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.0098 0.0098
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni myosin xvIII 0.0057 0.0098 0.0138
Giardia lamblia DINP protein human, muc B family 0.0019 0.0006 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0327 0.0762 0.2072
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0099 0.0203 0.0284
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0204 0.046 0.0644
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0762 0.1984
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0204 0.046 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi jmjC domain containing protein 0.0036 0.0048 0.0125
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0204 0.046 0.1185
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0095 0.0095
Echinococcus granulosus neuropeptide receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.0098 0.0146
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.0203 0.3498
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.2923 0.7138 0.7138
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1511
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0079 0.011
Loa Loa (eye worm) hypothetical protein 0.0099 0.0203 0.031
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0505 0.1314
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0034 0.0087
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0327 0.0762 0.0762
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.0098 0.0256
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1511
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0158 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.023 0.8837
Echinococcus multilocularis sex peptide receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0222 0.0505 0.1314
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.0098 0.0098
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.0098 0.0098
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0048 0.0067
Echinococcus multilocularis somatostatin receptor 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0203 0.0529
Giardia lamblia Phosphatidylinositol 4-kinase 0.0099 0.0203 0.1068
Loa Loa (eye worm) hypothetical protein 0.0234 0.0533 0.0828
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0564 0.1345 0.3505
Schistosoma mansoni cpg binding protein 0.0028 0.0027 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.3498
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0034 0.0034
Schistosoma mansoni coup transcription factor 0.003 0.0034 0.0047
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0034 0.0087
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2923 0.7138 0.7138
Echinococcus multilocularis orexin receptor type 2 0.0057 0.0098 0.0098
Toxoplasma gondii aldehyde dehydrogenase 0.0034 0.0042 0.0553
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.0042 0.0059
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0034 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0034 0.0087
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.0098 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.0936 0.0936
Leishmania major phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0552
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Echinococcus granulosus sex peptide receptor 0.0057 0.0098 0.0098
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0034 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.1101 0.172
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0057 0.0149
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.0203 0.0284
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0006 0.0016
Plasmodium vivax hypothetical protein 0.0099 0.0203 0.3498
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0087 0.0226
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Onchocerca volvulus 0.003 0.0034 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0204 0.046 0.1198
Loa Loa (eye worm) hypothetical protein 0.0538 0.1282 0.2004
Echinococcus granulosus FTZ F1 alpha 0.003 0.0034 0.0034
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.0098 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Onchocerca volvulus 0.0057 0.0098 0.068
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0253 0.058 0.7616
Schistosoma mansoni hypothetical protein 0.0304 0.0705 0.0988
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0099 0.0203 0.0529
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.0098 0.0098
Echinococcus multilocularis serine protein kinase ATM 0.0204 0.046 0.046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0051 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0383
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0253 0.058 0.1498
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.026 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0051 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Leishmania major phosphatidylinositol 3-kinase, putative 0.0253 0.058 0.1578
Echinococcus multilocularis peregrin 0.0029 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0078 0.0078
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1343 0.3259 0.849
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0099 0.0203 0.0514
Echinococcus granulosus hypothetical protein 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0204 0.046 0.1198
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.0354 0.0923
Schistosoma mansoni opsin-like receptor 0.0057 0.0098 0.0138
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0095 0.0133
Onchocerca volvulus 0.0057 0.0098 0.068
Schistosoma mansoni hypothetical protein 0.0398 0.0936 0.1312
Loa Loa (eye worm) RNA binding protein 0.0323 0.0753 0.1174
Onchocerca volvulus Alhambra homolog 0.0029 0.0029 0.0016
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0051 1
Brugia malayi mbt repeat family protein 0.0049 0.0079 0.0205
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) glutaminase 0.0266 0.0612 0.0952
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0203 0.7809
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.0098 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0253 0.058 0.0813
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0411 0.0968 0.5095
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0087 0.1139
Loa Loa (eye worm) hypothetical protein 0.0453 0.1071 0.1672
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0327 0.0762 0.0762
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.0098 0.0098
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0076 0.0198
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.0098 0.0098
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1042 0.2518 0.2518
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0253 0.058 0.1511
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0253 0.058 0.1511
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0087 0.0236
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.1042 0.2518 0.3946
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.0576 0.1501
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0034 0.0042 0.0042
Echinococcus granulosus geminin 0.0671 0.1607 0.1607
Echinococcus multilocularis 0.0099 0.0203 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0386 0.1005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0107
Entamoeba histolytica protein kinase rad3, putative 0.0204 0.046 0.1185
Brugia malayi G protein-coupled receptor 0.0057 0.0098 0.0256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0034 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0048 0.0066
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0051 0.0139
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) runx1 0.0057 0.0098 0.0145
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0051 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.023 0.8837
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0095 0.0095
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.1984
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0034 0.0087
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0006 0.0015
Onchocerca volvulus 0.0081 0.0158 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0204 0.046 0.1198
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0099 0.0203 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.0098 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Toxoplasma gondii thioredoxin reductase 0.0048 0.0078 0.1018
Schistosoma mansoni hypothetical protein 0.0035 0.0044 0.0062
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1579 0.3838 1
Echinococcus multilocularis musashi 0.0081 0.0158 0.0158
Toxoplasma gondii target of rapamycin (TOR), putative 0.0327 0.0762 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.1508
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0034 0.0087
Brugia malayi ecdysteroid receptor 0.003 0.0034 0.0087
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0327 0.0762 0.5662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Schistosoma mansoni alpha glucosidase 0.0036 0.0047 0.0065
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0386 0.1005
Schistosoma mansoni hypothetical protein 0.0671 0.1607 0.2251
Schistosoma mansoni hypothetical protein 0.0671 0.1607 0.2251
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.5662
Plasmodium vivax glutathione reductase, putative 0.0048 0.0078 0.1337
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0253 0.058 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0044 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi TAR-binding protein 0.0323 0.0753 0.1962
Brugia malayi FAT domain containing protein 0.0123 0.0261 0.0679
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0203 0.0529
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0095 0.0248
Echinococcus granulosus intermediate filament protein 0.0081 0.0158 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.0098 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0044 0.0062
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.0055 0.0095 0.014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0051 0.0833
Echinococcus granulosus serine protein kinase ATM 0.0204 0.046 0.046
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0034 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1102 0.2665 0.6943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0034 0.0044
Schistosoma mansoni lamin 0.0081 0.0158 0.0221
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.0098 0.0098
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0081 0.0158 0.0239
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0529
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0078 0.1337
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus tar DNA binding protein 0.0323 0.0753 0.0753
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0047 0.0127
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0015
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0029
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.0098 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.0098 0.0098
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0087 0.0087
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0095 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus granulosus neuropeptide receptor 0.0057 0.0098 0.0098
Echinococcus granulosus g-protein coupled receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0047 0.0121
Brugia malayi GnHR receptor homolog 0.0057 0.0098 0.0256
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.0533 0.0533
Brugia malayi hypothetical protein 0.0035 0.0044 0.0116
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0099 0.0203 0.1508
Brugia malayi sulfakinin receptor protein 0.0057 0.0098 0.0256
Trypanosoma cruzi target of rapamycin kinase 3 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.0226
Echinococcus multilocularis tar DNA binding protein 0.0323 0.0753 0.0753
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0034 0.0044
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0123 0.0261 0.0261
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.0098 0.0138
Onchocerca volvulus 0.0099 0.0203 0.1681
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0098 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0203 0.3498
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0051 0.1964
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0327 0.0762 0.1067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0047 0.0064
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.0098 0.0256
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.0533 0.0533
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0064 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0104 0.0154
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0253 0.058 0.1498
Echinococcus multilocularis Protein lozenge 0.0057 0.0098 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus multilocularis microtubule associated protein 2 0.1392 0.3379 0.3379
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.0098 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0047 0.0121
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.026 1
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0049 0.0079 0.049
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.1578
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0034 0.0087
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0253 0.058 0.1511
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1268 0.3073 0.8004
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) hypothetical protein 0.0039 0.0055 0.0077
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0047 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.1345 0.3495
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1042 0.2518 0.2518
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0327 0.0762 0.2072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0327 0.0762 0.0762
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.088
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0327 0.0762 0.0762
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0006
Echinococcus granulosus cpg binding protein 0.003 0.0031 0.0031
Onchocerca volvulus 0.0057 0.0098 0.068
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Loa Loa (eye worm) hypothetical protein 0.0105 0.0216 0.033
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0158 0.0412
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.148 0.3594 0.9363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0047 0.0047
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0034 0.0058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0034 0.0047
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0564 0.1345 0.1884
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.2072
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni glutaminase 0.0266 0.0612 0.0858
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0034 0.0042 0.0115
Brugia malayi larval opioid receptor 0.0057 0.0098 0.0256
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.0098 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0206 0.0466 0.0466
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0564 0.1345 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0123 0.0261 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi MH2 domain containing protein 0.0116 0.0243 0.0633
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.023 0.8837
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0034 0.0034
Brugia malayi AKH receptor 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0216 0.0563
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0098 0.0138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.0133
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0099 0.0203 0.0529
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.0354 0.0547
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0051 0.088
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0006
Brugia malayi Serotonin receptor 0.0057 0.0098 0.0256
Schistosoma mansoni intermediate filament proteins 0.0081 0.0158 0.0221
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.007 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.0762 0.1187
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Loa Loa (eye worm) phosphatidylinositol kinase 0.0099 0.0203 0.031
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0006 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi steroid hormone receptor 0.003 0.0034 0.0087
Schistosoma mansoni hypothetical protein 0.0099 0.0203 0.0284
Echinococcus granulosus allatostatin A receptor 0.0057 0.0098 0.0098
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2923 0.7138 1
Echinococcus multilocularis serotonin receptor 0.0057 0.0098 0.0098
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.0098 0.0098
Echinococcus granulosus dnaJ subfamily B 0.0398 0.0936 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0034 0.0034
Echinococcus multilocularis cpg binding protein 0.003 0.0031 0.0031
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0327 0.0762 0.1067
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0051 0.0051
Giardia lamblia PHD finger protein 15 0.0029 0.0029 0.0154
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0034 0.0047
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.0098 0.0138
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0051 0.0133
Onchocerca volvulus 0.0453 0.1071 1
Trichomonas vaginalis glutaminase, putative 0.0266 0.0612 0.1595
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0051 0.0379
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0564 0.1345 0.3505
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0098 0.0098
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0465 0.1101 0.2869
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Echinococcus granulosus lamin 0.0081 0.0158 0.0158
Leishmania major hypothetical protein, unknown function 0.0099 0.0203 0.0552
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0327 0.0762 0.5662
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0079 0.0079
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.0098 0.0138
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0034 0.0044
Schistosoma mansoni thyroid hormone receptor 0.003 0.0034 0.0047
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Schistosoma mansoni hypothetical protein 0.0057 0.0098 0.0138
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0034 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0052
Brugia malayi follicle stimulating hormone receptor 0.0057 0.0098 0.0256
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1579 0.3838 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0123 0.0261 0.04
Echinococcus multilocularis allatostatin A receptor 0.0057 0.0098 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0034 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0047 0.0121
Echinococcus multilocularis lamin dm0 0.0081 0.0158 0.0158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Brugia malayi ORL1-like opioid receptor 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0051 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0006 0.0043
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.0098 0.0098
Leishmania major phosphatidylinositol kinase related protein, putative 0.0099 0.0203 0.0552
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0099 0.0203 0.1508
Brugia malayi G-protein coupled receptor 0.0057 0.0098 0.0256
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1042 0.2518 0.6561
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.007 0.0101
Schistosoma mansoni survival motor neuron protein 0.0048 0.0076 0.0106
Leishmania major DNA polymerase kappa, putative 0.0019 0.0006 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0104 0.0146
Schistosoma mansoni alpha-glucosidase 0.0139 0.0299 0.0419
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0079 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.0098 0.0098
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Onchocerca volvulus 0.0099 0.0203 0.1681
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0034 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0261 0.0679
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0079 0.011
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0204 0.046 0.3419
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0114
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1579 0.3838 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.0098 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0034 0.0087
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.3498
Brugia malayi hypothetical protein 0.0234 0.0533 0.1388
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.0098 0.0098
Echinococcus multilocularis lamin 0.0081 0.0158 0.0158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0034 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.007 0.0098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0044 0.0044
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.0098 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi glutaminase DH11.1 0.0266 0.0612 0.1595
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0006 0.0015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Echinococcus granulosus jumonji domain containing protein 0.004 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0453 0.1071 0.1672
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0034 0.0047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.0203 0.0529
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0087 0.0226
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0051 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.0098 0.0098
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0089 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1579 0.3838 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0253 0.058 0.0902
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0253 0.058 0.4312
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0105 0.0216 0.0563
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.0098 0.0098
Brugia malayi jmjC domain containing protein 0.0094 0.0189 0.0493
Trypanosoma brucei protein kinase, putative 0.0052 0.0087 0.0645
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0087 0.0226
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.0098 0.0138
Schistosoma mansoni aldehyde dehydrogenase 0.0034 0.0042 0.0059
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0253 0.058 0.1511
Leishmania major trypanothione reductase 0.0048 0.0078 0.0211
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0449 0.0449
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0087 0.0236
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0098 0.0138
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.0098 0.0098
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0203 0.2664
Schistosoma mansoni histamine h1 receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0323 0.0753 0.1962
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1579 0.3838 1
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0006 0.0221
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0253 0.058 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1102 0.2665 0.6943
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Brugia malayi G-protein coupled receptor 0.0057 0.0098 0.0256
Leishmania major phosphatidylinositol kinase, putative 0.0099 0.0203 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0323 0.0753 0.1055
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Loa Loa (eye worm) glutathione reductase 0.0048 0.0078 0.0113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.0098 0.0138
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0034 0.0047
Schistosoma mansoni neuropeptide receptor 0.0057 0.0098 0.0138
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.0098 0.0146
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0079 0.0114
Echinococcus multilocularis dna polymerase eta 0.0019 0.0006 0.0006
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0057 0.0057
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0076
Brugia malayi Dopamine receptor protein 2 0.0057 0.0098 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0203 0.031
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0034 0.0087
Loa Loa (eye worm) glutaminase 2 0.0266 0.0612 0.0952
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0222 0.0505 0.6625
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Schistosoma mansoni DNA polymerase eta 0.0019 0.0006 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.2611 0.6373 1
Echinococcus granulosus serotonin receptor 0.0057 0.0098 0.0098
Loa Loa (eye worm) MBCTL1 0.0055 0.0095 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Echinococcus granulosus fmrfamide receptor 0.0057 0.0098 0.0098
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0383
Loa Loa (eye worm) hypothetical protein 0.0204 0.046 0.0713
Entamoeba histolytica hypothetical protein 0.1268 0.3073 0.8004
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0204 0.046 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0006 0.0043
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0099 0.0203 0.0284
Onchocerca volvulus 0.0057 0.0098 0.068
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0503
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.0354 0.0354
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0149
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi hypothetical protein 0.0057 0.0098 0.0256
Echinococcus granulosus lamin dm0 0.0081 0.0158 0.0158
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0064 0.0167
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.1345 0.3495
Toxoplasma gondii exonuclease III APE 0.0038 0.0051 0.067
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0087 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi Dopamine receptor 0.0057 0.0098 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.1414 0.3432 0.8941
Plasmodium falciparum glutathione reductase 0.0048 0.0078 0.1337
Loa Loa (eye worm) TAR-binding protein 0.0323 0.0753 0.1174
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0189 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0034 0.0034
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0066 0.0094
Echinococcus multilocularis fmrfamide receptor 0.0057 0.0098 0.0098
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0051 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0216 0.0563
Onchocerca volvulus 0.0093 0.0188 0.1535
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0364 0.0948
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4088 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0087 0.0087
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0099 0.0203 0.0529
Echinococcus granulosus peregrin 0.0029 0.0029 0.0029
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.023 0.8837
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.0098 0.0098
Echinococcus granulosus dna polymerase eta 0.0019 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.0098 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0034 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.007 0.007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0034 0.0044
Onchocerca volvulus 0.0057 0.0098 0.068
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0203 0.0203
Schistosoma mansoni fkbp-rapamycin associated protein 0.0204 0.046 0.0644
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.0098 0.0138
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Brugia malayi Serotonin receptor 0.0057 0.0098 0.0256
Echinococcus multilocularis geminin 0.0671 0.1607 0.1607
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0034 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0047 0.0121
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1579 0.3838 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0327 0.0762 0.2072
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.0098 0.0146
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0078 0.0113
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0327 0.0762 0.1972
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0047 0.0047
Mycobacterium tuberculosis Probable reductase 0.011 0.023 0.8837
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0034 0.0044
Brugia malayi Melatonin receptor type 1A 0.0057 0.0098 0.0256
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.0098 0.068
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.0098 0.0098
Onchocerca volvulus 0.0057 0.0098 0.068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0034 0.0042 0.0688
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.026 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0094
Leishmania major DNA polymerase eta, putative 0.0019 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.007 0.0182
Schistosoma mansoni biogenic amine receptor 0.0057 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Schistosoma mansoni ap endonuclease 0.0038 0.0051 0.0071
Loa Loa (eye worm) hypothetical protein 0.0222 0.0505 0.0783
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Brugia malayi mbt repeat family protein 0.0049 0.0079 0.0205
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0044
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0064 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0264
Onchocerca volvulus 0.0057 0.0098 0.068
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Echinococcus granulosus g protein coupled receptor 0.0057 0.0098 0.0098
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0006 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0204 0.046 0.1198
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.0098 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0346
Brugia malayi neuropeptide F receptor 0.0057 0.0098 0.0256
Schistosoma mansoni amine GPCR 0.0057 0.0098 0.0138
Brugia malayi nuclear hormone receptor 0.003 0.0034 0.0087
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0034 0.0042 0.1622
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.073 0.1753 0.456
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0095 0.0095
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0327 0.0762 0.1984
Echinococcus multilocularis g protein coupled receptor 0.0057 0.0098 0.0098
Brugia malayi hypothetical protein 0.0025 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.0057 0.0098 0.0146
Loa Loa (eye worm) hypothetical protein 0.0537 0.1279 0.1999
Schistosoma mansoni nuclear hormone receptor 0.003 0.0034 0.0047
Schistosoma mansoni alpha-glucosidase 0.0139 0.0299 0.0419
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0047 0.0121
Schistosoma mansoni lamin 0.0081 0.0158 0.0221
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0564 0.1345 0.3505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.046 0.1198
Echinococcus granulosus orexin receptor type 2 0.0057 0.0098 0.0098
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0142 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0327 0.0762 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0762 0.1984
Entamoeba histolytica hypothetical protein 0.0035 0.0044 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.0576 0.1501
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0087 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0034 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.0098 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0034 0.0087
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0048 0.0048
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.0098 0.0098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0243 0.0373
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.0762 0.1187
Plasmodium falciparum thioredoxin reductase 0.0048 0.0078 0.1337
Schistosoma mansoni cpg binding protein 0.003 0.0031 0.0044
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.0098 0.0098
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0078 0.0202
Schistosoma mansoni adenoreceptor 0.0057 0.0098 0.0138
Entamoeba histolytica hypothetical protein 0.0099 0.0203 0.0514
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0243 0.0373
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0099 0.0203 0.3498
Brugia malayi MAP kinase sur-1 0.0052 0.0087 0.0226
Onchocerca volvulus 0.0057 0.0098 0.068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0006 0.0221
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0079 0.0079
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.0098 0.0138
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0087 0.0457
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0099 0.0203 0.0529

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 109 nM Binding affinity for adenosine A1 receptor was assayed by displacment of [3H]-DPCPX from rat cortical membranes. ChEMBL. 10649980
Ki (binding) = 6550 nM Binding affinity for adenosine A2A receptor was determined by displacment of [3H]-DPCPX from rat striatal membranes. ChEMBL. 10649980
Ki (binding) = 100 uM Inhibition calf intestine adenosine deaminase ChEMBL. 7562937
TC50 (ADMET) > 100 uM In vitro evaluation of cytotoxicity in C8166 cells infected with HIV-1 IIIB. ChEMBL. 7562937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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