Detailed information for compound 936687

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.922 | Formula: C21H27ClFN5O4
  • H donors: 2 H acceptors: 4 LogP: 2.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](COc1cc(Cl)c(cc1F)c1onc(n1)N1CCN(CC1)C(=O)C1CCCC1)N
  • InChi: 1S/C21H27ClFN5O4/c22-16-10-18(31-12-14(24)11-29)17(23)9-15(16)19-25-21(26-32-19)28-7-5-27(6-8-28)20(30)13-3-1-2-4-13/h9-10,13-14,29H,1-8,11-12,24H2/t14-/m0/s1
  • InChiKey: ODBIGVFIHLGZHT-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 3 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0462 0.035 0.303
Entamoeba histolytica protein kinase, putative 0.0633 0.0586 0.5075
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.035 0.035
Loa Loa (eye worm) AGC/PKA protein kinase 0.0658 0.0621 0.0755
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0738 0.0731 0.0731
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Brugia malayi hypothetical protein 0.0587 0.0523 0.0636
Plasmodium vivax calcium-dependent protein kinase, putative 0.0462 0.035 0.303
Entamoeba histolytica protein kinase, putative 0.0318 0.0151 0.1308
Loa Loa (eye worm) hypothetical protein 0.0865 0.0906 0.1103
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0395 0.0258 0.0314
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3852
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0529 0.0442 0.3822
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0693 0.0668 0.0813
Loa Loa (eye worm) hypothetical protein 0.0688 0.0661 0.0805
Schistosoma mansoni tyrosine kinase 0.0416 0.0287 0.0748
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0921 0.0983 0.1719
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0309 0.0138 0.0242
Echinococcus multilocularis protein kinase shaggy 0.1046 0.1155 0.1155
Loa Loa (eye worm) hypothetical protein 0.0251 0.0058 0.0071
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0658 0.0621 0.1086
Schistosoma mansoni protein kinase 0.0785 0.0796 0.2077
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0462 0.035 0.303
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0367 0.0959
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0221 0.0017 0.003
Schistosoma mansoni protein kinase 0.035 0.0195 0.0509
Schistosoma mansoni vav2 0.0357 0.0205 0.0536
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0223 0.002 0.002
Echinococcus granulosus cyclin dependent kinase 9 0.0351 0.0196 0.0334
Echinococcus multilocularis calcium dependent protein kinase 0.0321 0.0155 0.0155
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.0621
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0318 0.0151 0.0257
Brugia malayi map kinase activated protein kinase protein 2 0.0493 0.0392 0.0477
Brugia malayi Protein kinase domain containing protein 0.0395 0.0258 0.0314
Echinococcus granulosus tyrosine protein kinase Blk 0.0738 0.0731 0.1242
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0835
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Echinococcus multilocularis hemicentin 1 0.0248 0.0055 0.0055
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Schistosoma mansoni tyrosine kinase 0.2985 0.3831 1
Schistosoma mansoni serine/threonine protein kinase 0.1372 0.1605 0.419
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.2055 0.2548 0.3101
Plasmodium falciparum calcium-dependent protein kinase 3 0.0462 0.035 0.303
Schistosoma mansoni tyrosine kinase 0.0774 0.078 0.2036
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0529 0.0442 0.3822
Echinococcus granulosus rho-associated protein kinase 1 0.0716 0.0701 0.1192
Echinococcus granulosus casein kinase I delta 0.0554 0.0477 0.0811
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0098
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.035 0.0195 0.0341
Echinococcus multilocularis fibroblast growth factor receptor 4 0.129 0.1493 0.1493
Entamoeba histolytica protein kinase domain containing protein 0.032 0.0153 0.1326
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.0621
Entamoeba histolytica protein kinase domain containing protein 0.103 0.1133 0.9809
Loa Loa (eye worm) hypothetical protein 0.0683 0.0655 0.0797
Brugia malayi Sex muscle abnormal protein 5 0.032 0.0154 0.0187
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0525 0.0437 0.0531
Schistosoma mansoni cell adhesion molecule 0.0279 0.0098 0.0255
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0933 0.0999 0.1749
Brugia malayi SH2 domain containing protein 0.0684 0.0656 0.0798
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0554 0.0477 0.0581
Echinococcus granulosus tyrosine protein kinase Src42A 0.0878 0.0923 0.157
Echinococcus granulosus dual specificity testis-specific protein kinase 0.035 0.0195 0.0332
Echinococcus granulosus growth factor receptor bound protein 2 0.0335 0.0174 0.0295
Entamoeba histolytica PH domain containing protein kinase, putative 0.03 0.0126 0.109
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0395 0.0258 0.2232
Echinococcus granulosus beta-adrenergic receptor kinase 0.0269 0.0084 0.0143
Echinococcus granulosus mitogen activated protein kinase 11 0.435 0.5715 0.9716
Echinococcus multilocularis 0.0779 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0888 0.0938 0.1142
Onchocerca volvulus 0.0254 0.0063 0.0077
Onchocerca volvulus 0.0683 0.0655 0.0797
Loa Loa (eye worm) TK/KIN16 protein kinase 0.3077 0.3958 0.4818
Echinococcus multilocularis dual specificity mitogen activated protein 0.1106 0.1239 0.1239
Echinococcus multilocularis serine threonine protein kinase 0.0515 0.0422 0.0422
Echinococcus granulosus aminopeptidase N 0.063 0.0582 0.0989
Schistosoma mansoni tyrosine kinase 0.0597 0.0535 0.1397
Brugia malayi Immunoglobulin I-set domain containing protein 0.034 0.0182 0.0221
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0376 0.0231 0.0231
Plasmodium falciparum calcium-dependent protein kinase 1 0.0462 0.035 0.303
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1858 0.2276 0.3869
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0462 0.035 0.303
Brugia malayi Protein kinase domain containing protein 0.0475 0.0367 0.0447
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0647 0.0606 0.0737
Echinococcus multilocularis cGMP dependent protein kinase 1 0.024 0.0044 0.0044
Trypanosoma cruzi cdc2-related kinase 3 0.0395 0.0258 0.0451
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2441 0.3081 0.3081
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0318 0.0151 0.0151
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.035 0.035
Loa Loa (eye worm) CAMK protein kinase 0.034 0.0182 0.0221
Entamoeba histolytica hypothetical protein 0.0211 0.0003 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0573 0.0503 0.1313
Trichomonas vaginalis AGC family protein kinase 0.0658 0.0621 0.501
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0086 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0658 0.0621 0.162
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0475 0.0367 0.0367
Loa Loa (eye worm) TK protein kinase 0.0558 0.0482 0.0587
Trichomonas vaginalis CMGC family protein kinase 0.0395 0.0258 0.2081
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0658 0.0621 0.1086
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0475 0.0367 0.0447
Plasmodium falciparum serine/threonine protein kinase KIN 0.0309 0.0138 0.1195
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1258 0.1448 0.3781
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Echinococcus multilocularis cyclin dependent kinase 0.0395 0.0258 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Trypanosoma brucei protein kinase, putative 0.035 0.0195 0.0341
Echinococcus granulosus Immunoglobulin 0.0551 0.0472 0.0803
Loa Loa (eye worm) hypothetical protein 0.0827 0.0853 0.1038
Schistosoma mansoni protein kinase 0.0318 0.0151 0.0394
Echinococcus granulosus tyrosine protein kinase ABL1 0.2044 0.2534 0.4307
Plasmodium falciparum NIMA related kinase 1 0.0242 0.0046 0.0395
Schistosoma mansoni nephrin 0.075 0.0747 0.1949
Schistosoma mansoni vam6/vps39 related 0.0587 0.0523 0.1364
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0244 0.0049 0.0086
Echinococcus multilocularis neuroglian 0.0718 0.0704 0.0704
Onchocerca volvulus 0.0389 0.0249 0.0303
Schistosoma mansoni kinase 0.032 0.0153 0.04
Echinococcus granulosus roundabout 2 0.083 0.0858 0.1459
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0587 0.0523 0.0523
Echinococcus multilocularis dual specificity protein kinase clk2 0.0921 0.0983 0.0983
Trichomonas vaginalis STE family protein kinase 0.0318 0.0151 0.122
Schistosoma mansoni titin 0.034 0.0182 0.0474
Loa Loa (eye worm) variant SH3 domain-containing protein 0.022 0.0015 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0442 0.3564
Schistosoma mansoni serine/threonine kinase 0.0475 0.0367 0.0959
Loa Loa (eye worm) hypothetical protein 0.0888 0.0938 0.1142
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Echinococcus granulosus insulin receptor 0.1211 0.1383 0.2351
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus granulosus defective proboscis extension response 0.0551 0.0472 0.0803
Giardia lamblia Kinase, CAMK CAMKL 0.034 0.0181 0.1463
Schistosoma mansoni serine/threonine protein kinase 0.0395 0.0258 0.0673
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1295 0.1499 0.2549
Toxoplasma gondii histone kinase SNF1, putative 0.0309 0.0138 0.1195
Echinococcus granulosus serine:threonine protein kinase TAO1 0.2219 0.2775 0.4717
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0921 0.0983 0.1719
Echinococcus granulosus hypothetical protein 0.0779 0.0788 0.1339
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0462 0.035 0.0612
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0882 0.093 0.093
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Echinococcus granulosus calcium activated potassium channel 0.0271 0.0086 0.0145
Plasmodium vivax casein kinase 1, putative 0.0554 0.0477 0.4131
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0442 0.0537
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0269 0.0084 0.0102
Loa Loa (eye worm) hypothetical protein 0.0445 0.0326 0.0397
Onchocerca volvulus 0.0389 0.0249 0.0303
Echinococcus multilocularis slit 2 protein 0.0247 0.0053 0.0053
Entamoeba histolytica protein kinase, putative 0.0244 0.0049 0.0428
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Entamoeba histolytica protein kinase, putative 0.103 0.1133 0.9809
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Echinococcus granulosus tyrosine protein kinase HCK 0.0558 0.0482 0.0819
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0923 0.0923
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.0367 0.0959
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0442 0.3564
Loa Loa (eye worm) IKK protein kinase 0.6161 0.8216 1
Echinococcus granulosus neuroglian 0.0718 0.0704 0.1196
Entamoeba histolytica cell division protein kinase 2, putative 0.0427 0.0301 0.2606
Brugia malayi Egg laying defective protein 4 0.024 0.0044 0.0053
Toxoplasma gondii AGC kinase 0.0658 0.0621 0.5373
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.0099 0.0173
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0279 0.0098 0.0255
Plasmodium vivax glycogen synthase kinase 3, putative 0.1046 0.1155 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0389 0.0249 0.2154
Trypanosoma brucei aurora B kinase 0.0529 0.0442 0.0773
Loa Loa (eye worm) hypothetical protein 0.0389 0.0249 0.0303
Echinococcus multilocularis tyrosine protein kinase Abl 0.1161 0.1315 0.1315
Brugia malayi EGF-like domain containing protein 0.0247 0.0053 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus granulosus activin receptor type 0.3638 0.4733 0.8046
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0376 0.0231 0.0281
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0462 0.035 0.303
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0544 0.0463 0.0463
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0658 0.0621 0.5373
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.026 0.0071 0.0087
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0306 0.0135 0.0164
Loa Loa (eye worm) variant SH3 domain-containing protein 0.032 0.0154 0.0187
Brugia malayi Tyrosine-protein kinase abl-1 0.1023 0.1123 0.1367
Loa Loa (eye worm) hypothetical protein 0.3539 0.4596 0.5594
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0262 0.0073 0.0633
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0729 0.0718 0.122
Schistosoma mansoni serine/threonine-protein kinase 0.03 0.0126 0.0329
Entamoeba histolytica PH domain containing protein kinase, putative 0.03 0.0126 0.109
Schistosoma mansoni hypothetical protein 0.0254 0.0063 0.0165
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.129 0.1493 0.1493
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0554 0.0477 0.0835
Echinococcus granulosus serine:threonine protein kinase N2 0.0897 0.095 0.1615
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.129 0.1493 0.2538
Echinococcus granulosus tyrosine kinase 0.0738 0.0731 0.1242
Echinococcus granulosus hemicentin 1 0.0248 0.0055 0.0093
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0829 0.0857 0.1043
Loa Loa (eye worm) TK/ROR protein kinase 0.0376 0.0231 0.0282
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.035 0.0195 0.0341
Brugia malayi serine/threonine kinase 12 0.0529 0.0442 0.0537
Schistosoma mansoni tyrosine kinase 0.0774 0.078 0.2036
Brugia malayi Variant SH3 domain containing protein 0.022 0.0015 0.0019
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0319 0.0152 0.0398
Schistosoma mansoni hypothetical protein 0.0254 0.0063 0.0165
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.1055
Echinococcus multilocularis serine:threonine protein kinase 38 0.0475 0.0367 0.0367
Trypanosoma brucei protein kinase, putative 0.1046 0.1155 0.2021
Onchocerca volvulus 0.063 0.0582 0.0708
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1885 0.2314 0.2314
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0395 0.0258 0.0451
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1228 0.1407 0.2392
Echinococcus multilocularis rho associated protein kinase 0.0716 0.0701 0.0701
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0395 0.0258 0.0314
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.435 0.5715 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0878 0.0923 0.157
Schistosoma mansoni protein kinase 0.1106 0.1239 0.3234
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0309 0.0138 0.0242
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0269 0.0083 0.0083
Leishmania major protein kinase A catalytic subunit isoform 2 0.0658 0.0621 0.1086
Brugia malayi Protein kinase domain containing protein 0.0693 0.0668 0.0813
Entamoeba histolytica protein kinase, putative 0.0335 0.0175 0.1513
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0269 0.0083 0.0141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0462 0.035 0.0595
Trichomonas vaginalis AGC family protein kinase 0.0513 0.042 0.3392
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.032 0.0153 0.0186
Brugia malayi C1-like domain containing protein 0.0968 0.1048 0.1276
Echinococcus granulosus raf serine:threonine protein kinase 0.0347 0.0192 0.0326
Echinococcus granulosus dual specificity 0.103 0.1133 0.1926
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0921 0.0983 0.1719
Leishmania major protein kinase A catalytic subunit 0.0658 0.0621 0.1086
Trypanosoma cruzi cdc2-related kinase 3 0.0395 0.0258 0.0451
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0138 0.036
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0395 0.0258 0.0451
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0244 0.0049 0.0086
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0242 0.0046 0.0395
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0878 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0799 0.0815 0.0992
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Echinococcus multilocularis peroxidasin 0.0251 0.0058 0.0058
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.028 0.0099 0.012
Brugia malayi STE20-like kinase MST 0.0359 0.0208 0.0253
Loa Loa (eye worm) hypothetical protein 0.0631 0.0583 0.071
Giardia lamblia Kinase, CK1 Casein kinase 0.0554 0.0477 0.3852
Schistosoma mansoni protein kinase 0.2004 0.2478 0.6468
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0914
Onchocerca volvulus 0.0865 0.0906 0.1103
Trichomonas vaginalis CAMK family protein kinase 0.035 0.0196 0.158
Leishmania major protein kinase A catalytic subunit isoform 1 0.0658 0.0621 0.1086
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1046 0.1155 0.3015
Echinococcus granulosus calcium dependent protein kinase 0.0321 0.0155 0.0263
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.435 0.5715 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0595 0.0533 0.0649
Trypanosoma brucei cdc2-related kinase 1 0.0395 0.0258 0.0451
Echinococcus multilocularis cyclin dependent kinase 5 0.0395 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0683 0.0655 0.0797
Echinococcus multilocularis ephrin type A receptor 4 A 0.0271 0.0086 0.0086
Loa Loa (eye worm) TK/INSR protein kinase 0.1211 0.1383 0.1683
Schistosoma mansoni serine/threonine protein kinase 0.0915 0.0974 0.2543
Brugia malayi Doublecortin family protein 0.0256 0.0065 0.008
Schistosoma mansoni cell adhesion molecule 0.0279 0.0098 0.0255
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0303
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0098
Echinococcus granulosus c-Jun N-terminal kinases 0.2441 0.3081 0.5237
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0229 0.0028 0.0073
Echinococcus multilocularis tyrosine protein kinase shark 0.0597 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0247 0.0053 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Schistosoma mansoni serine/threonine protein kinase 0.0915 0.0974 0.2543
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.1106 0.1239 0.2168
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.059 0.0526 0.0526
Echinococcus granulosus contactin 0.0279 0.0098 0.0166
Leishmania major protein kinase, putative 0.035 0.0195 0.0341
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1228 0.1407 0.1407
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0882 0.093 0.1581
Brugia malayi Protein kinase domain containing protein 0.0921 0.0983 0.1196
Echinococcus multilocularis serine:threonine protein kinase 3 0.0359 0.0208 0.0208
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0044 0.0114
Brugia malayi Peptidase family M1 containing protein 0.063 0.0582 0.0708
Giardia lamblia Kinase, AGC PKA 0.0658 0.0621 0.501
Entamoeba histolytica protein kinase domain containing protein 0.0529 0.0442 0.3822
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0044 0.0114
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0359 0.0208 0.0253
Echinococcus granulosus slit 2 protein 0.0247 0.0053 0.0089
Trypanosoma brucei casein kinase I, isoform 2 0.0554 0.0477 0.0835
Onchocerca volvulus 0.0716 0.0701 0.0853
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0084 0.0219
Entamoeba histolytica serine/threonine protein kinase, putative 0.028 0.0099 0.0853
Brugia malayi Protein kinase domain containing protein 0.1885 0.2314 0.2817
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Brugia malayi Furin-like cysteine rich region family protein 0.0909 0.0966 0.1176
Schistosoma mansoni serine/threonine kinase 0.0382 0.0239 0.0624
Brugia malayi protein kinase C3,putative 0.0361 0.021 0.0256
Brugia malayi Protein kinase domain containing protein 0.035 0.0196 0.0238
Trypanosoma cruzi Protein kinase B 0.03 0.0126 0.022
Trichomonas vaginalis AGC family protein kinase 0.0506 0.0411 0.3315
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.435 0.5715 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0475 0.0367 0.0367
Onchocerca volvulus 0.0575 0.0506 0.0616
Echinococcus multilocularis activin receptor type 0.3638 0.4733 0.4733
Echinococcus granulosus casein kinase I delta 0.0554 0.0477 0.0811
Schistosoma mansoni serine/threonine protein kinase 0.2219 0.2775 0.7243
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0303
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0774 0.078 0.1326
Plasmodium falciparum protein serine/threonine kinase-1 0.0921 0.0983 0.8507
Schistosoma mansoni serine/threonine protein kinase 0.1228 0.1407 0.3672
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0921 0.0983 0.1719
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1885 0.2314 0.2817
Trypanosoma cruzi rac serine-threonine kinase, putative 0.03 0.0126 0.022
Loa Loa (eye worm) hypothetical protein 0.0683 0.0655 0.0797
Schistosoma mansoni serine/threonine protein kinase 0.039 0.025 0.0652
Onchocerca volvulus 0.0688 0.0661 0.0805
Onchocerca volvulus 0.0389 0.0249 0.0303
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.1449 0.1712 0.2084
Schistosoma mansoni ephrin receptor 0.0271 0.0086 0.0224
Echinococcus granulosus cyclin dependent kinase 19 0.1449 0.1712 0.2911
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0318 0.0151 0.0151
Onchocerca volvulus Serine\/threonine kinase homolog 0.0269 0.0083 0.0101
Echinococcus granulosus cyclin dependent kinase 1 0.0395 0.0258 0.0438
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.069 0.0665 0.0809
Echinococcus multilocularis cyclin dependent kinase 9 0.032 0.0153 0.0153
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0835
Brugia malayi Protein kinase domain containing protein 0.103 0.1133 0.1379
Giardia lamblia Kinase, CMGC DYRK 0.0244 0.0049 0.0399
Echinococcus multilocularis tyrosine protein kinase Blk 0.0738 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0549 0.047 0.0572
Leishmania major protein kinase, putative 0.0921 0.0983 0.1719
Schistosoma mansoni adapter molecule crk 0.032 0.0154 0.0401
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.039 0.025 0.025
Brugia malayi Protein kinase c protein 2 0.032 0.0154 0.0187
Loa Loa (eye worm) hypothetical protein 0.0565 0.0492 0.0599
Leishmania major casein kinase, putative 0.0554 0.0477 0.0835
Brugia malayi serine/threonine protein kinase 6 0.0529 0.0442 0.0537
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0475 0.0367 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Schistosoma mansoni serine/threonine protein kinase 0.032 0.0153 0.04
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1242 0.1426 0.1426
Echinococcus multilocularis MAM 0.0254 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Loa Loa (eye worm) AGC/PKA protein kinase 0.0658 0.0621 0.0755
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Echinococcus multilocularis cGMP dependent protein kinase 1 0.024 0.0044 0.0044
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0462 0.035 0.303
Schistosoma mansoni protein kinase 0.2004 0.2478 0.6468
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0244 0.0049 0.006
Loa Loa (eye worm) TK/FAK protein kinase 0.3018 0.3877 0.4719
Entamoeba histolytica protein kinase domain containing protein 0.1046 0.1155 1
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0797 0.0812 0.0989
Schistosoma mansoni serine/threonine protein kinase 0.0654 0.0614 0.1603
Brugia malayi casein kinase 1, delta 0.0554 0.0477 0.0581
Brugia malayi Protein kinase domain containing protein 0.0633 0.0586 0.0714
Loa Loa (eye worm) hypothetical protein 0.026 0.0071 0.0087
Echinococcus granulosus protein kinase shaggy 0.1046 0.1155 0.1964
Trichomonas vaginalis CAMK family protein kinase 0.0221 0.0017 0.014
Brugia malayi cyclin-dependent kinase 9 0.032 0.0153 0.0186
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0684 0.0656 0.0656
Schistosoma mansoni serine/threonine protein kinase 0.0526 0.0437 0.1142
Echinococcus granulosus protein kinase c epsilon type 0.0615 0.0561 0.0953
Onchocerca volvulus 0.0286 0.0106 0.0129
Loa Loa (eye worm) sex muscle abnormal protein 5 0.032 0.0154 0.0187
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.022 0.0015 0.0019
Giardia lamblia Kinase, CMGC CDK 0.0395 0.0258 0.2081
Echinococcus granulosus serine:threonine protein kinase MARK2 0.039 0.025 0.0424
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.4471 0.5882 1
Schistosoma mansoni growth factor receptor-bound protein 0.032 0.0154 0.0401
Brugia malayi Fes/CIP4 homology domain containing protein 0.064 0.0596 0.0725
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0303
Echinococcus multilocularis tyrosine kinase 0.0389 0.0249 0.0249
Echinococcus multilocularis protein kinase c iota type 0.0694 0.067 0.067
Echinococcus multilocularis casein kinase I gamma 0.0317 0.0149 0.0149
Echinococcus multilocularis expressed conserved protein 0.024 0.0044 0.0044
Brugia malayi protein-tyrosine kinase 0.0738 0.0731 0.0889
Schistosoma mansoni vesicular amine transporter 0.0551 0.0472 0.1233
Echinococcus granulosus protein kinase c iota type 0.0694 0.067 0.114
Entamoeba histolytica protein kinase domain containing protein 0.0306 0.0135 0.1167
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0493 0.0392 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.0395 0.0258 0.0673
Trichomonas vaginalis AGC family protein kinase 0.022 0.0015 0.0124
Echinococcus multilocularis neuroglian 0.0279 0.0098 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0086 0.0223
Schistosoma mansoni tyrosine kinase 0.0565 0.0492 0.1285
Plasmodium falciparum calcium-dependent protein kinase 5 0.0462 0.035 0.303
Brugia malayi Protein kinase domain containing protein 0.1211 0.1383 0.1683
Echinococcus multilocularis protein KINase family member (kin 25) 0.0719 0.0704 0.0704
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0878 0.0923 0.0923
Schistosoma mansoni serine/threonine protein kinase 0.0654 0.0614 0.1603
Loa Loa (eye worm) hypothetical protein 0.1534 0.1829 0.2226
Plasmodium falciparum protein kinase, putative 0.035 0.0195 0.1688
Brugia malayi Protein kinase domain containing protein 0.1534 0.1829 0.2226
Entamoeba histolytica hypothetical protein 0.037 0.0222 0.1924
Loa Loa (eye worm) hypothetical protein 0.0254 0.0063 0.0077
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0244 0.0049 0.0086
Brugia malayi Variant SH3 domain containing protein 0.032 0.0154 0.0187
Echinococcus multilocularis hemicentin 1 0.0248 0.0055 0.0055
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.2219 0.2775 0.3378
Loa Loa (eye worm) TK protein kinase 0.0504 0.0407 0.0496
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Giardia lamblia Kinase, NEK 0.0242 0.0046 0.0368
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0462 0.035 0.0426
Entamoeba histolytica tyrosin kinase, putative 0.0248 0.0054 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.103 0.1133 0.2957
Schistosoma mansoni protein kinase 0.035 0.0195 0.0509
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0654 0.0614 0.0614
Echinococcus granulosus serine:threonine kinase SAD 1 0.0309 0.0138 0.0235
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1858 0.2276 0.2276
Entamoeba histolytica protein kinase, putative 0.0529 0.0442 0.3822
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.2004 0.2478 0.2478
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0462 0.035 0.303
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0367 0.0218 0.0266
Loa Loa (eye worm) hypothetical protein 0.0279 0.0098 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0138 0.036
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0529 0.0442 0.3822
Echinococcus granulosus roundabout 2 0.0279 0.0098 0.0166
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0526 0.0437 0.0532
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0223 0.002 0.0034
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.2219 0.2775 0.2775
Loa Loa (eye worm) hypothetical protein 0.1243 0.1428 0.1738
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0551 0.0472 0.1233
Echinococcus granulosus cyclin dependent kinase 0.0395 0.0258 0.0438
Trypanosoma cruzi cdc2-related kinase 1 0.0395 0.0258 0.0451
Loa Loa (eye worm) hypothetical protein 0.0462 0.035 0.0426
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0811
Brugia malayi Protein kinase domain containing protein 0.0269 0.0083 0.0101
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0309 0.0138 0.0242
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0738 0.0731 0.1242
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0318 0.0151 0.0257
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.103 0.1133 0.1983
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.1106 0.1239 0.2168
Brugia malayi Variant SH3 domain containing protein 0.032 0.0154 0.0187
Giardia lamblia Kinase, NEK 0.0242 0.0046 0.0368
Echinococcus multilocularis tyrosine protein kinase Srms 0.0738 0.0731 0.0731
Plasmodium falciparum calcium-dependent protein kinase 4 0.0462 0.035 0.303
Onchocerca volvulus 0.0554 0.0477 0.0581
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1046 0.1155 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0921 0.0983 0.8507
Echinococcus granulosus tyrosine protein kinase shark 0.0597 0.0535 0.091
Echinococcus multilocularis roundabout 2 0.0279 0.0098 0.0098
Echinococcus multilocularis tyrosine protein kinase HCK 0.0558 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.051 0.0416 0.0507
Echinococcus multilocularis cyclin dependent kinase 7 0.0525 0.0437 0.0437
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0262 0.0073 0.0633
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0309 0.0138 0.0242
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2044 0.2534 0.2534
Echinococcus multilocularis serine:threonine protein kinase N2 0.0897 0.095 0.095
Schistosoma mansoni serine/threonine protein kinase 0.1423 0.1676 0.4375
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.435 0.5715 0.6956
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0319 0.0152 0.0398
Onchocerca volvulus 0.0389 0.0249 0.0303
Echinococcus granulosus cGMP dependent protein kinase 1 0.024 0.0044 0.0074
Schistosoma mansoni tyrosine kinase 0.0878 0.0923 0.241
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1542 0.184 0.224
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.0135 0.0352
Entamoeba histolytica casein kinase, putative 0.0554 0.0477 0.4131
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.035 0.0195 0.0341
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0595 0.0533 0.0649
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.028 0.0099 0.0173
Schistosoma mansoni kinase 0.0343 0.0186 0.0486
Trichomonas vaginalis STE family protein kinase 0.0318 0.0151 0.122
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0442 0.0537
Echinococcus multilocularis rac serine:threonine kinase 0.03 0.0126 0.0126
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0211 0.0004 0.0032
Echinococcus multilocularis mitogen activated protein kinase 11 0.435 0.5715 0.5715
Echinococcus multilocularis growth factor receptor bound protein 2 0.032 0.0154 0.0154
Echinococcus multilocularis aminopeptidase N 0.063 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.1158 0.131 0.1595
Schistosoma mansoni protein kinase 0.0529 0.0442 0.1153
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1295 0.1499 0.1825
Echinococcus granulosus tyrosine protein kinase Srms 0.0785 0.0796 0.1353
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0835
Brugia malayi Protein kinase domain containing protein 0.0396 0.0258 0.0315
Entamoeba histolytica protein kinase, putative 0.0322 0.0156 0.135
Schistosoma mansoni tyrosine kinase 0.0528 0.0441 0.1152
Entamoeba histolytica protein kinase, putative 0.0335 0.0175 0.1513
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.0437 0.114
Schistosoma mansoni serine/threonine protein kinase 0.1885 0.2314 0.604
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1046 0.1155 0.1964
Echinococcus granulosus serine:threonine protein kinase PLK1 0.028 0.0099 0.0168
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0693 0.0668 0.0813
Loa Loa (eye worm) hypothetical protein 0.1325 0.1541 0.1876
Echinococcus granulosus mitogen activated protein kinase 14 0.435 0.5715 0.9716
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0529 0.0442 0.0751
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0517 0.0426 0.0426
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0878 0.0923 0.0923
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0297 0.0122 0.0148
Loa Loa (eye worm) TK/EPH protein kinase 0.0288 0.0109 0.0133
Brugia malayi Protein kinase domain containing protein 0.4003 0.5237 0.6375
Brugia malayi hypothetical protein 0.0254 0.0063 0.0077
Echinococcus granulosus tyrosine protein kinase Src64B 0.0878 0.0923 0.157
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0319 0.0152 0.0152
Schistosoma mansoni growth factor receptor-bound protein 0.0335 0.0174 0.0454
Plasmodium falciparum glycogen synthase kinase 3 0.1046 0.1155 1
Echinococcus granulosus titin 0.034 0.0182 0.0309
Schistosoma mansoni serine/threonine protein kinase 0.0504 0.0407 0.1064
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1542 0.184 0.224
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0894 0.0947 0.1152
Brugia malayi Prion-like- 0.0248 0.0055 0.0066
Echinococcus granulosus serine:threonine protein kinase N2 0.1372 0.1605 0.2729
Brugia malayi SH2 domain containing protein 0.0389 0.0249 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0083 0.0217
Echinococcus multilocularis casein kinase I delta 0.0554 0.0477 0.0477
Leishmania major protein kinase, putative 0.0462 0.035 0.0612
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0658 0.0621 0.1086
Brugia malayi Protein kinase domain containing protein 0.1931 0.2376 0.2893
Toxoplasma gondii aurora kinase 0.0529 0.0442 0.3822
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0551 0.0472 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0375 0.023 0.039
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.069 0.0665 0.0809
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0462 0.035 0.0426
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0658 0.0621 0.1086
Schistosoma mansoni serine/threonine protein kinase 0.0462 0.035 0.0914
Loa Loa (eye worm) hypothetical protein 0.0475 0.0368 0.0448
Entamoeba histolytica protein kinase, putative 0.0633 0.0586 0.5075
Loa Loa (eye worm) AGC/PKN protein kinase 0.1372 0.1605 0.1954
Loa Loa (eye worm) hypothetical protein 0.032 0.0154 0.0187
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.1055
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0319 0.0152 0.0186
Loa Loa (eye worm) hypothetical protein 0.0551 0.0472 0.0575
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.028 0.0099 0.0099
Entamoeba histolytica protein kinase, putative 0.0558 0.0482 0.4172
Schistosoma mansoni protein kinase 0.0554 0.0477 0.1246
Loa Loa (eye worm) TK/ALK protein kinase 0.4002 0.5235 0.6372
Schistosoma mansoni serine/threonine protein kinase 0.0493 0.0392 0.1023
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0244 0.0049 0.0428
Plasmodium vivax serine/threonine kinase-1, putative 0.0921 0.0983 0.8507
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0462 0.035 0.0595
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0395 0.0258 0.0314
Echinococcus granulosus NDR protein kinase 0.0475 0.0367 0.0625
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0462 0.035 0.035
Loa Loa (eye worm) hypothetical protein 0.0551 0.0472 0.0575
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0514 0.0421 0.0421
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0319 0.0152 0.0259
Echinococcus granulosus serine:threonine protein kinase 0.026 0.0071 0.0121
Brugia malayi Protein kinase domain containing protein 0.0297 0.0122 0.0148
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.0621
Brugia malayi Protein kinase domain containing protein 0.0376 0.0231 0.0281
Entamoeba histolytica hypothetical protein 0.103 0.1133 0.9809
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0923 0.157
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0395 0.0258 0.0438
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0811
Onchocerca volvulus 0.0244 0.0049 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Entamoeba histolytica serine/threonine protein kinase, putative 0.0309 0.0138 0.1195
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0279 0.0098 0.0166
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0878 0.0923 0.157
Trypanosoma cruzi cdc2-related kinase 1 0.0395 0.0258 0.0451
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0921 0.0983 0.1719
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1046 0.1155 0.2021
Entamoeba histolytica protein kinase, putative 0.0211 0.0004 0.0032
Echinococcus multilocularis titin 0.034 0.0182 0.0182
Schistosoma mansoni tyrosine kinase 0.0565 0.0492 0.1285
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0306 0.0135 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0138 0.0361
Echinococcus multilocularis N chimaerin 0.0319 0.0152 0.0152
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0306 0.0135 0.0229
Onchocerca volvulus 0.6161 0.8216 1
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1295 0.1499 0.1499
Entamoeba histolytica protein kinase, putative 0.0595 0.0533 0.4618
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Giardia lamblia Kinase, NEK 0.0242 0.0046 0.0368
Entamoeba histolytica PH domain containing protein kinase, putative 0.0697 0.0673 0.5829
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0921 0.0983 0.1719
Brugia malayi Protein kinase domain 0.0318 0.0151 0.0184
Brugia malayi protein C17H12.11 0.0549 0.047 0.0572
Schistosoma mansoni protein kinase 0.0318 0.0151 0.0394
Brugia malayi probable protein kinase 0.1384 0.1623 0.1975
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0658 0.0621 0.1086
Echinococcus granulosus tm gpcr rhodopsin 0.0514 0.0421 0.0716
Brugia malayi serine/threonine-protein kinase 6 0.0529 0.0442 0.0537
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2055 0.2548 0.2548
Schistosoma mansoni tyrosine kinase 0.1211 0.1383 0.361
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Giardia lamblia Kinase, CMGC GSK 0.1046 0.1155 0.9324
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.0442 0.1153
Echinococcus granulosus tyrosine protein kinase Src42A 0.0544 0.0463 0.0787
Onchocerca volvulus 0.0389 0.0249 0.0303
Echinococcus multilocularis lachesin 0.0248 0.0055 0.0055
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.103 0.1133 0.1983
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0182 0.0474
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0462 0.035 0.0426
Entamoeba histolytica protein kinase, putative 0.0462 0.035 0.303
Onchocerca volvulus 0.1046 0.1155 0.1406
Trypanosoma cruzi polo-like protein kinase, putative 0.028 0.0099 0.0173
Echinococcus multilocularis tyrosine protein kinase otk 0.0248 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.051 0.0416 0.0507
Entamoeba histolytica protein kinase domain containing protein 0.1046 0.1155 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Brugia malayi cyclin-dependent kinase 7 homolog 0.0556 0.048 0.0584
Schistosoma mansoni serine/threonine protein kinase 0.0921 0.0983 0.2565
Echinococcus granulosus TGF-beta receptor type-1 0.0785 0.0796 0.1353
Leishmania major protein kinase, putative 0.0529 0.0442 0.0773
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0636
Loa Loa (eye worm) AGC/AKT protein kinase 0.0633 0.0586 0.0714
Echinococcus multilocularis casein kinase i 0.0554 0.0477 0.0477
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0306 0.0135 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.0347 0.0192 0.05
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.1106 0.1239 0.2168
Loa Loa (eye worm) hypothetical protein 0.0554 0.0476 0.0579
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0334 0.0172 0.1392
Trichomonas vaginalis STE family protein kinase 0.1106 0.1239 1
Brugia malayi Protein kinase domain containing protein 0.2055 0.2548 0.3101
Brugia malayi Cam kinase protein 1 0.0462 0.035 0.0426
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1243 0.1428 0.2427
Schistosoma mansoni serine/threonine protein kinase 0.0554 0.0477 0.1246
Echinococcus multilocularis cyclin dependent kinase 19 0.1449 0.1712 0.1712
Brugia malayi bone morphogenetic protein type 1 receptor 0.0852 0.0889 0.1082
Brugia malayi Tyrosine-protein kinase abl-1 0.1161 0.1315 0.1601
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.1055
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Loa Loa (eye worm) protein kinase domain-containing protein 0.0317 0.0149 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Brugia malayi Immunoglobulin I-set domain containing protein 0.0582 0.0515 0.0627
Loa Loa (eye worm) hypothetical protein 0.0254 0.0063 0.0077
Trypanosoma brucei rac serine-threonine kinase, putative 0.0633 0.0586 0.1026
Toxoplasma gondii AGC kinase 0.0658 0.0621 0.5373
Onchocerca volvulus 0.0281 0.01 0.0121
Toxoplasma gondii casein kinase I 0.0554 0.0477 0.4131
Echinococcus granulosus cGMP dependent protein kinase 1 0.024 0.0044 0.0074
Loa Loa (eye worm) AUR protein kinase 0.0529 0.0442 0.0537
Giardia lamblia Aurora kinase 0.0529 0.0442 0.3564
Schistosoma mansoni protein kinase 0.035 0.0195 0.0509
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0262 0.0073 0.0128
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0414 0.0284 0.0346
Echinococcus granulosus protein kinase C gamma type 0.0515 0.0422 0.0718
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0279 0.0098 0.0098
Brugia malayi putative serine/threonine kinase SADA gamma 0.0309 0.0138 0.0168
Giardia lamblia Kinase, CMGC GSK 0.1046 0.1155 0.9324
Echinococcus granulosus casein kinase I gamma 0.0317 0.0149 0.0253
Echinococcus multilocularis raf serine:threonine protein kinase 0.0347 0.0192 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.028 0.0099 0.0257
Echinococcus granulosus lachesin 0.0248 0.0055 0.0093
Schistosoma mansoni nephrin 0.0279 0.0098 0.0255
Echinococcus granulosus serine:threonine protein kinase 0.026 0.0071 0.0121
Brugia malayi Protein kinase domain containing protein 0.0389 0.0249 0.0303
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0785 0.0796 0.0796
Brugia malayi Protein kinase domain containing protein 0.069 0.0665 0.0809
Echinococcus granulosus protein kinase 0.0797 0.0812 0.1381
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3852
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0248 0.0055 0.0066
Plasmodium vivax protein kinase, putative 0.0223 0.002 0.0175
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Loa Loa (eye worm) hypothetical protein 0.0658 0.0621 0.0755
Brugia malayi Protein kinase domain containing protein 0.0709 0.0691 0.0841
Brugia malayi serine/threonine-protein kinase PAK 7 0.1799 0.2195 0.2672
Brugia malayi RhoGAP domain containing protein 0.0319 0.0152 0.0186
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0493 0.0392 0.0666
Echinococcus multilocularis TGF beta receptor type 1 0.0785 0.0796 0.0796
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0658 0.0621 0.0621
Echinococcus granulosus epidermal growth factor receptor 0.0774 0.078 0.1326
Schistosoma mansoni titin 0.0248 0.0055 0.0143
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0914
Trypanosoma brucei SNF1-related protein kinases, putative 0.0309 0.0138 0.0242
Echinococcus multilocularis serine:threonine protein kinase N2 0.0475 0.0367 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0084 0.0219
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2055 0.2548 0.4331
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0376 0.0231 0.0393
Echinococcus multilocularis serine:threonine protein kinase N2 0.1372 0.1605 0.1605
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1643 0.198 0.198
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1885 0.2314 0.2817
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.035 0.0195 0.1688
Schistosoma mansoni ephrin receptor 0.024 0.0043 0.0112
Echinococcus multilocularis PAK box P21 Rho binding 0.0297 0.0122 0.0122
Echinococcus multilocularis 0.0797 0.0812 0.0812
Schistosoma mansoni roundabout 0.0248 0.0055 0.0143
Schistosoma mansoni tyrosine kinase 0.0878 0.0923 0.241
Schistosoma mansoni protein kinase 0.1384 0.1623 0.4236
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1046 0.1155 0.1155
Schistosoma mansoni tyrosine kinase 0.129 0.1493 0.3897
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0248 0.0055 0.0066
Echinococcus multilocularis twitchin 0.0309 0.0138 0.0138
Echinococcus multilocularis Immunoglobulin 0.0551 0.0472 0.0472
Echinococcus multilocularis mitogen activated protein kinase 14 0.435 0.5715 0.5715
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2441 0.3081 0.375
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0882 0.093 0.1132
Loa Loa (eye worm) hypothetical protein 0.0582 0.0515 0.0627
Echinococcus multilocularis insulin receptor 0.1211 0.1383 0.1383
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.1106 0.1239 0.1508
Entamoeba histolytica p21-activated kinase 0.0356 0.0204 0.1765
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0248 0.0055 0.0066
Echinococcus granulosus TGF beta receptor type 1 0.0785 0.0796 0.1353
Echinococcus multilocularis cyclin dependent kinase 9 0.0351 0.0196 0.0196
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0279 0.0098 0.0119
Schistosoma mansoni tyrosine kinase 0.0364 0.0215 0.0561
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Schistosoma mansoni serine/threonine protein kinase 0.039 0.025 0.0652
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0658 0.0621 0.0755
Plasmodium falciparum calcium-dependent protein kinase 2 0.0462 0.035 0.303
Giardia lamblia Kinase, AGC PKA 0.0262 0.0073 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0271 0.0086 0.0223
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0882 0.093 0.1132
Brugia malayi Protein kinase domain containing protein 0.6161 0.8216 1
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.1106 0.1239 0.1508
Giardia lamblia Kinase, CAMK CAMKL 0.034 0.0181 0.1463
Schistosoma mansoni protein kinase 0.0797 0.0812 0.212
Echinococcus granulosus twitchin 0.086 0.0899 0.1528
Brugia malayi Temporarily assigned gene name protein 59 0.0587 0.0523 0.0636
Plasmodium falciparum serine/threonine protein kinase, putative 0.0529 0.0442 0.3822
Loa Loa (eye worm) hypothetical protein 0.0449 0.0331 0.0403
Echinococcus granulosus serine:threonine protein kinase 3 0.0359 0.0208 0.0353
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.039 0.025 0.025
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1046 0.1155 0.2021
Echinococcus multilocularis serine:threonine protein kinase 0.026 0.0071 0.0071
Brugia malayi SRC-1 0.0878 0.0923 0.1124
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0138 0.036
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0256 0.0065 0.008
Echinococcus multilocularis protein tyrosine kinase 0.2985 0.3831 0.3831
Loa Loa (eye worm) hypothetical protein 0.0799 0.0815 0.0992
Loa Loa (eye worm) hypothetical protein 0.05 0.0403 0.049
Echinococcus granulosus serine threonine protein kinase nrc 0.0262 0.0073 0.0124
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0554 0.0477 0.0581
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0262 0.0073 0.0124
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.103 0.1133 0.1983
Entamoeba histolytica protein kinase, putative 0.0297 0.0122 0.1056
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0878 0.0923 0.0923
Echinococcus multilocularis dual specificity 0.103 0.1133 0.1133
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0631 0.0583 0.0992
Trypanosoma brucei protein kinase, putative 0.0222 0.0018 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Schistosoma mansoni serine/threonine protein kinase 0.0716 0.0701 0.1829
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0529 0.0442 0.0442
Echinococcus granulosus neuroglian 0.0279 0.0098 0.0166
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0719 0.0704 0.1197
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0545 0.0465 0.0566
Brugia malayi Peroxidasin 0.0251 0.0058 0.0071
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1242 0.1426 0.2425
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0493 0.0392 0.0392
Entamoeba histolytica protein kinase, putative 0.1046 0.1155 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0528 0.0441 0.1152
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0322 0.0156 0.135
Brugia malayi hypothetical protein 0.2219 0.2775 0.3378
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Echinococcus multilocularis Immunoglobulin 0.0551 0.0472 0.0472
Echinococcus granulosus roundabout 2 0.0279 0.0098 0.0166
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0923 0.0923
Echinococcus granulosus tyrosine kinase 0.0389 0.0249 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Schistosoma mansoni neuroglian 0.0279 0.0098 0.0255
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0658 0.0621 0.1086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0414 0.0284 0.0346
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1046 0.1155 0.1406
Schistosoma mansoni septate junction protein 0.0248 0.0055 0.0143
Echinococcus granulosus serine:threonine protein kinase MARK2 0.039 0.025 0.0424
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.435 0.5715 1
Echinococcus granulosus Vam6:Vps39 protein 0.0587 0.0523 0.0888
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0923 0.157
Schistosoma mansoni serine/threonine protein kinase 0.0658 0.0621 0.162
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0878 0.0923 0.0923
Entamoeba histolytica protein kinase , putative 0.0529 0.0442 0.3822
Schistosoma mansoni tyrosine kinase 0.1864 0.2285 0.5964
Echinococcus multilocularis dual specificity testis specific protein kinase 0.035 0.0195 0.0195
Plasmodium vivax protein kinase Crk2 0.0395 0.0258 0.2232
Loa Loa (eye worm) hypothetical protein 0.0475 0.0368 0.0448
Brugia malayi casein kinase I 0.0554 0.0477 0.0581
Trichomonas vaginalis CMGC family protein kinase 0.0395 0.0258 0.2081
Onchocerca volvulus Tyrosine kinase homolog 0.2613 0.3318 0.4039
Onchocerca volvulus 0.0587 0.0523 0.0636
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0475 0.0367 0.0625
Echinococcus granulosus Protein kinase C brain isozyme 0.0654 0.0614 0.1044
Loa Loa (eye worm) hypothetical protein 0.0719 0.0704 0.0857
Echinococcus granulosus activated cdc42 kinase 1 0.1534 0.1829 0.3109
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0413 0.0282 0.0494
Entamoeba histolytica protein kinase domain containing protein 0.035 0.0195 0.1688
Echinococcus granulosus protein tyrosine kinase 0.2985 0.3831 0.6513
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Echinococcus multilocularis casein kinase I delta 0.0554 0.0477 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0587 0.0523 0.0888
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0878 0.0923 0.0923
Echinococcus granulosus ephrin type A receptor 4 A 0.0271 0.0086 0.0146
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1046 0.1155 0.1406
Loa Loa (eye worm) hypothetical protein 0.0309 0.0138 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.026 0.0071 0.0576
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Echinococcus granulosus serine/threonine protein kinase 0.03 0.0126 0.0214
Trichomonas vaginalis STE family protein kinase 0.0318 0.0151 0.122
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0309 0.0138 0.0168
Giardia lamblia Kinase, CMGC CDK 0.0395 0.0258 0.2081
Schistosoma mansoni protein kinase 0.2004 0.2478 0.6468
Trypanosoma brucei cdc2-related kinase 3 0.0395 0.0258 0.0451
Echinococcus multilocularis NCK adaptor protein 0.0335 0.0174 0.0174
Brugia malayi hypothetical protein 0.0549 0.047 0.0572
Brugia malayi cell division control protein 2 homolog 0.0395 0.0258 0.0314
Echinococcus granulosus MAM 0.0254 0.0063 0.0108
Echinococcus multilocularis casein kinase I alpha 0.0554 0.0477 0.0477
Loa Loa (eye worm) hypothetical protein 0.0842 0.0874 0.1063
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0309 0.0138 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.2441 0.3081 0.8041
Giardia lamblia Kinase, PLK 0.028 0.0099 0.0796
Schistosoma mansoni tyrosine kinase 0.1733 0.2103 0.549
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.034 0.0182 0.0221
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1423 0.1676 0.204
Entamoeba histolytica casein kinase 1, putative 0.0554 0.0477 0.4131
Entamoeba histolytica cell division protein kinase 2, putative 0.0395 0.0258 0.2232
Schistosoma mansoni hypothetical protein 0.0587 0.0523 0.1364
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Brugia malayi Protein kinase domain containing protein 0.0317 0.0149 0.0181
Giardia lamblia Kinase, AGC AKT 0.0894 0.0947 0.7641
Schistosoma mansoni tyrosine kinase 0.1211 0.1383 0.361
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0318 0.0151 0.0257
Echinococcus multilocularis mitogen activated protein kinase 11 0.435 0.5715 0.5715
Brugia malayi Protein kinase domain containing protein 0.3018 0.3877 0.4719
Plasmodium falciparum casein kinase 1 0.0554 0.0477 0.4131
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.025 0.0057 0.0097
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0684 0.0656 0.1115
Schistosoma mansoni serine/threonine-protein kinase 0.03 0.0126 0.0329
Entamoeba histolytica protein kinase domain containing protein 0.0244 0.0049 0.0428
Loa Loa (eye worm) hypothetical protein 0.0822 0.0847 0.1031
Trichomonas vaginalis STE family protein kinase 0.1106 0.1239 1
Loa Loa (eye worm) TK/FER protein kinase 0.0684 0.0656 0.0798
Trichomonas vaginalis CK1 family protein kinase 0.0554 0.0477 0.3852
Echinococcus granulosus aurora kinase A 0.0529 0.0442 0.0751
Trichomonas vaginalis STE family protein kinase 0.0318 0.0151 0.122
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0835
Onchocerca volvulus 0.0827 0.0853 0.1038
Loa Loa (eye worm) hypothetical protein 0.0779 0.0788 0.0959
Brugia malayi Serine/threonine-protein kinase SULU 0.2219 0.2775 0.3378
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0367 0.2966
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0551 0.0472 0.1233
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0318 0.0151 0.0151
Trichomonas vaginalis CMGC family protein kinase 0.1046 0.1155 0.9324
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0517 0.0426 0.0724
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1228 0.1407 0.1713
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0149 0.0389
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.024 0.0044 0.0377
Schistosoma mansoni nck2/grb4 0.032 0.0154 0.0401
Schistosoma mansoni cell adhesion molecule 0.0248 0.0055 0.0143
Schistosoma mansoni septate junction protein 0.0248 0.0055 0.0143
Echinococcus granulosus tyrosine protein kinase Lyn 0.1019 0.1118 0.1901
Trichomonas vaginalis CAMK family protein kinase 0.0221 0.0017 0.014
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Echinococcus multilocularis protein kinase c epsilon type 0.0615 0.0561 0.0561
Echinococcus granulosus cyclin dependent kinase 9 0.032 0.0153 0.026
Echinococcus multilocularis transfer RNA-Thr 0.1534 0.1829 0.1829
Echinococcus multilocularis mitogen activated protein kinase 14 0.435 0.5715 0.5715
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0587 0.0523 0.1364
Trichomonas vaginalis AGC family protein kinase 0.0633 0.0586 0.4732
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.035 0.0196 0.0238
Onchocerca volvulus 0.0389 0.0249 0.0303
Schistosoma mansoni protein kinase 0.0297 0.0122 0.0318
Schistosoma mansoni rap gtpase-activating protein 0.0587 0.0523 0.1364
Entamoeba histolytica PH domain containing protein kinase, putative 0.0697 0.0673 0.5829
Echinococcus granulosus STE20 serine:threonine protein kinase 0.059 0.0526 0.0895
Schistosoma mansoni serine/threonine protein kinase 0.0615 0.0561 0.1464
Trichomonas vaginalis CAMK family protein kinase 0.0462 0.035 0.2825
Brugia malayi protein unc-22 0.034 0.0182 0.0221
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Entamoeba histolytica protein kinase 2, putative 0.0262 0.0073 0.0633
Trichomonas vaginalis CAMK family protein kinase 0.0311 0.0142 0.1144
Onchocerca volvulus 0.034 0.0182 0.0221
Brugia malayi Protein kinase domain containing protein 0.0475 0.0367 0.0447
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0636
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0915 0.0974 0.0974
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0269 0.0083 0.0101
Trichomonas vaginalis STE family protein kinase 0.0297 0.0122 0.0985
Schistosoma mansoni serine/threonine protein kinase 0.1449 0.1712 0.4469
Echinococcus multilocularis roundabout 2 0.083 0.0858 0.0858
Brugia malayi Protein kinase domain containing protein 0.0526 0.0437 0.0532
Echinococcus granulosus tyrosine protein kinase otk 0.0248 0.0055 0.0093
Echinococcus granulosus c src tyrosine kinase 0.0528 0.0441 0.075
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.025 0.0057 0.0057
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0658 0.0621 0.1086
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1295 0.1499 0.1825
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0587 0.0523 0.1364
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0658 0.0621 0.5373
Schistosoma mansoni protein kinase 0.2055 0.2548 0.665
Trichomonas vaginalis STE family protein kinase 0.1106 0.1239 1
Loa Loa (eye worm) hypothetical protein 0.0582 0.0515 0.0627
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1643 0.198 0.3366
Brugia malayi hypothetical protein 0.0582 0.0515 0.0627
Giardia lamblia Kinase, CMGC CLK 0.0921 0.0983 0.7932
Brugia malayi protein kinase C II. 0.0615 0.0561 0.0683
Echinococcus granulosus fibroblast growth factor receptor 4 0.129 0.1493 0.2538
Echinococcus granulosus dual specificity protein kinase clk2 0.0921 0.0983 0.1671
Echinococcus multilocularis serine:threonine protein kinase 0.026 0.0071 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.0437 0.114
Brugia malayi ephrin receptor 1 precursor 0.0238 0.004 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0921 0.0983 0.2565
Echinococcus multilocularis dual specificity 0.0244 0.0049 0.0049
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0529 0.0442 0.3822
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0309 0.0138 0.0138
Echinococcus granulosus cyclin dependent kinase 7 0.0525 0.0437 0.0742
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0254 0.0063 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0852 0.0889 0.1082
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0554 0.0477 0.0581
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Echinococcus multilocularis 0.021 0.0002 0.0002
Brugia malayi serine/threonine-protein kinase plk-2 0.028 0.0099 0.012
Brugia malayi Stress-activated protein kinase jnk-1 0.2441 0.3081 0.375
Schistosoma mansoni protein kinase C mu 0.0968 0.1048 0.2736
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0248 0.0055 0.0143
Loa Loa (eye worm) hypothetical protein 0.0693 0.0668 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Entamoeba histolytica protein kinase domain containing protein 0.0248 0.0054 0.0471
Loa Loa (eye worm) thyroid receptor interactor 0.064 0.0596 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0882 0.093 0.2427
Brugia malayi Variant SH3 domain containing protein 0.0319 0.0152 0.0186
Loa Loa (eye worm) gastrulation defective protein 1 0.1308 0.1517 0.1847
Loa Loa (eye worm) SRC-1 0.0878 0.0923 0.1124
Echinococcus granulosus cGMP dependent protein kinase 0.024 0.0044 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0049 0.0129
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Echinococcus granulosus titin 0.034 0.0182 0.0309
Loa Loa (eye worm) TK/EGFR protein kinase 0.0909 0.0966 0.1176
Echinococcus multilocularis epidermal growth factor receptor 0.0774 0.078 0.078
Loa Loa (eye worm) hypothetical protein 0.0218 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0921 0.0983 0.1196
Trichomonas vaginalis TKL family protein kinase 0.0211 0.0003 0.0021
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1423 0.1676 0.204
Schistosoma mansoni tyrosine kinase 0.0457 0.0343 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.2004 0.2478 0.4212
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0658 0.0621 0.5373
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0244 0.0049 0.006
Trypanosoma cruzi aurora B kinase, putative 0.0529 0.0442 0.0773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Echinococcus multilocularis calcium activated potassium channel 0.0271 0.0086 0.0086
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0046 0.0368
Loa Loa (eye worm) AGC/PKG protein kinase 0.024 0.0044 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0055 0.0066
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0968 0.1048 0.1276
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0729 0.0718 0.0718
Trichomonas vaginalis CMGC family protein kinase 0.0921 0.0983 0.7932
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0587 0.0523 0.0914
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.034 0.0181 0.1569
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.0138 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.0138 0.1115
Onchocerca volvulus Serine\/threonine kinase homolog 0.028 0.0099 0.012
Loa Loa (eye worm) TK/FER protein kinase 0.0389 0.0249 0.0303
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0221 0.0017 0.0017
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0968 0.1048 0.1276
Schistosoma mansoni protein kinase 0.0297 0.0122 0.0318
Trypanosoma brucei polo-like protein kinase 0.028 0.0099 0.0173
Toxoplasma gondii AGC kinase 0.0595 0.0533 0.4618
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0098 0.0119
Schistosoma mansoni ste20-related kinase 0.0309 0.0138 0.0361
Brugia malayi Protein kinase domain containing protein 0.1449 0.1712 0.2084
Echinococcus granulosus activated cdc42 kinase 1 0.1534 0.1829 0.3109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0462 0.035 0.0595
Entamoeba histolytica protein kinase, putative 0.0529 0.0442 0.3822
Entamoeba histolytica hypothetical protein 0.0211 0.0004 0.0032
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0615 0.0561 0.0683
Brugia malayi Protein kinase domain containing protein 0.0545 0.0465 0.0566
Brugia malayi intracellular kinase 0.1046 0.1155 0.1406
Brugia malayi Fibronectin type III domain containing protein 0.0582 0.0515 0.0627
Loa Loa (eye worm) hypothetical protein 0.0582 0.0515 0.0627
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0279 0.0098 0.0098
Trichomonas vaginalis STE family protein kinase 0.0242 0.0046 0.0368
Onchocerca volvulus 0.0413 0.0282 0.0343
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0262 0.0073 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.1467 0.1737 0.4534
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1931 0.2376 0.2893
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0915 0.0974 0.1656
Loa Loa (eye worm) hypothetical protein 0.0688 0.0661 0.0805
Echinococcus multilocularis c src tyrosine kinase 0.0528 0.0441 0.0441
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.032 0.0154 0.0401
Brugia malayi Immunoglobulin I-set domain containing protein 0.1458 0.1724 0.2099
Echinococcus multilocularis cyclin dependent kinase 1 0.0395 0.0258 0.0258
Schistosoma mansoni atypical protein kinase C 0.07 0.0679 0.1771
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0878 0.0923 0.0923
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1799 0.2195 0.2672
Schistosoma mansoni cell adhesion molecule 0.0663 0.0627 0.1635
Trichomonas vaginalis CMGC family protein kinase 0.0395 0.0258 0.2081
Plasmodium falciparum protein kinase 5 0.0395 0.0258 0.2232
Echinococcus granulosus NCK adaptor protein 0.032 0.0154 0.0261
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0376 0.0231 0.0231
Echinococcus granulosus dual specificity mitogen activated protein 0.1106 0.1239 0.2106
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0442 0.3564
Trichomonas vaginalis CMGC family protein kinase 0.1046 0.1155 0.9324
Echinococcus multilocularis beta adrenergic receptor kinase 0.0269 0.0084 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.028 0.0099 0.0796
Echinococcus multilocularis roundabout 2 0.0279 0.0098 0.0098
Echinococcus multilocularis epidermal growth factor receptor 0.0909 0.0966 0.0966
Trichomonas vaginalis AGC family protein kinase 0.0529 0.0442 0.3564
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1885 0.2314 0.2817
Brugia malayi P38 map kinase family protein 2 0.435 0.5715 0.6956
Trypanosoma cruzi casein kinase, putative 0.0554 0.0477 0.0835
Echinococcus multilocularis aurora kinase A 0.0529 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0587 0.0523 0.0636
Onchocerca volvulus 0.2237 0.2799 0.3407
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0248 0.0055 0.0055
Schistosoma mansoni tyrosine kinase 0.0719 0.0704 0.1838
Echinococcus granulosus epidermal growth factor receptor 0.0909 0.0966 0.1643
Loa Loa (eye worm) TK protein kinase 0.1458 0.1724 0.2099
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1885 0.2314 0.3934
Brugia malayi Hr1 repeat family protein 0.1372 0.1605 0.1954
Entamoeba histolytica protein kinase, putative 0.103 0.1133 0.9809
Loa Loa (eye worm) TK/ABL protein kinase 0.2044 0.2534 0.3084
Schistosoma mansoni protein kinase 0.0852 0.0889 0.2319
Schistosoma mansoni tyrosine kinase 0.0528 0.0441 0.1152
Brugia malayi Immunoglobulin I-set domain containing protein 0.3077 0.3958 0.4818
Echinococcus granulosus tyrosine protein kinase Fyn 0.0878 0.0923 0.157
Echinococcus granulosus cyclin dependent kinase 5 0.0395 0.0258 0.0438
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.103 0.1133 0.1379
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0421 0.0293 0.0356
Loa Loa (eye worm) hypothetical protein 0.0248 0.0055 0.0066
Echinococcus granulosus peroxidasin 0.0251 0.0058 0.0099
Echinococcus granulosus N chimaerin 0.0319 0.0152 0.0259
Loa Loa (eye worm) TK protein kinase 0.0738 0.0731 0.0889
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0242 0.0046 0.0395
Giardia lamblia Kinase, STE STE20 0.1106 0.1239 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.051 0.0416 0.0506
Trichomonas vaginalis AGC family protein kinase 0.0475 0.0367 0.2966
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1885 0.2314 0.2817
Loa Loa (eye worm) hypothetical protein 0.0254 0.0063 0.0077
Schistosoma mansoni tyrosine kinase 0.0909 0.0966 0.2522
Leishmania major protein kinase, putative 0.0921 0.0983 0.1719
Schistosoma mansoni tyrosine kinase 0.0565 0.0492 0.1285
Brugia malayi hypothetical protein 0.0389 0.0249 0.0303
Brugia malayi Protein kinase domain containing protein 0.0693 0.0668 0.0813
Echinococcus granulosus dual specificity 0.0244 0.0049 0.0084
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.103 0.1133 0.1983
Echinococcus multilocularis cyclin dependent kinase 1 0.0395 0.0258 0.0258
Entamoeba histolytica protein kinase, putative 0.0475 0.0367 0.3181
Echinococcus multilocularis activated cdc42 kinase 1 0.1534 0.1829 0.1829
Giardia lamblia Kinase, STE STE20 0.0318 0.0151 0.122
Entamoeba histolytica protein kinase, putative 0.0463 0.0352 0.3045
Loa Loa (eye worm) AGC/NDR protein kinase 0.0475 0.0367 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0658 0.0621 0.162
Brugia malayi Protein kinase domain containing protein 0.026 0.0071 0.0087
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1295 0.1499 0.1825
Trichomonas vaginalis CMGC family protein kinase 0.0244 0.0049 0.0399
Echinococcus granulosus casein kinase i 0.0554 0.0477 0.0811
Plasmodium falciparum cGMP-dependent protein kinase 0.024 0.0044 0.0377
Echinococcus granulosus casein kinase I alpha 0.0554 0.0477 0.0811
Onchocerca volvulus Slit protein homolog 0.0247 0.0053 0.0064

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1.7 nM Agonist activity at human S1P1 receptor expressed in human EDG1-bla U2OS cells after 18 hrs by beta-arrestin recruitment assay ChEMBL. 25241927
EC50 (binding) > 10000 nM Agonist activity at human S1P3 receptor expressed in human EDG3-bla U2OS cells after 18 hrs by beta-arrestin recruitment assay ChEMBL. 25241927

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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