TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.961 | Formula: C25H18ClN5O2S
H donors: 2 H acceptors: 3 LogP: 5.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)Nc1nc(c(s1)c1nc2ccccc2c(=O)n1c1ccc(cc1)C(=O)C)N
InChi: 1S/C25H18ClN5O2S/c1-14(32)15-6-12-18(13-7-15)31-23(29-20-5-3-2-4-19(20)24(31)33)21-22(27)30-25(34-21)28-17-10-8-16(26)9-11-17/h2-13H,27H2,1H3,(H,28,30)
InChiKey: NHFVPDZXUOPXIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0136	0.0106	0.019
Plasmodium falciparum	transporter, putative	0.1008	0.0931	1
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0014	0.0025
Loa Loa (eye worm)	transcription factor SMAD2	0.0258	0.0221	0.0221
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0136	0.0106	0.019
Brugia malayi	hypothetical protein	0.0088	0.0061	0.0061
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.003	0.0006	0.0003
Loa Loa (eye worm)	melatonin receptor type 1A	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0192	0.0158	0.0283
Brugia malayi	G protein-coupled receptor F59B2.13	0.0136	0.0106	0.0106
Echinococcus multilocularis	neuropeptides capa receptor	0.0136	0.0106	0.019
Schistosoma mansoni	neuropeptide receptor	0.0136	0.0106	0.019
Schistosoma mansoni	glutamate receptor AMPA	0.0235	0.02	0.0357
Echinococcus granulosus	neuropeptides capa receptor	0.0136	0.0106	0.019
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0272	0.0234	0.0234
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0103	0.0075	0.0075
Brugia malayi	GnHR receptor homolog	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.034	0.0298	0.0533
Leishmania major	squalene synthase, putative	0.1063	0.0982	0.0982
Echinococcus multilocularis	nmda type glutamate receptor	0.0381	0.0337	0.0603
Leishmania major	UDP-galactopyranose mutase	0.0216	0.0181	0.0181
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0136	0.0106	0.019
Brugia malayi	neuropeptide F receptor	0.0136	0.0106	0.0106
Leishmania major	hypothetical protein, conserved	0.0272	0.0234	0.0234
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0195	0.0162	0.1235
Echinococcus granulosus	serotonin receptor	0.0136	0.0106	0.019
Brugia malayi	Cytochrome P450 family protein	0.004	0.0015	0.0015
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0192	0.0158	0.0283
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0088	0.0061	0.0061
Brugia malayi	Serotonin receptor	0.0136	0.0106	0.0106
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0086	0.0058	0.0417
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0192	0.0158	0.0158
Entamoeba histolytica	hypothetical protein, conserved	0.0155	0.0124	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0011	0.002
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Entamoeba histolytica	hypothetical protein	0.0036	0.0011	0.0874
Schistosoma mansoni	glutamate receptor NMDA	0.0515	0.0464	0.083
Trypanosoma cruzi	trypanothione reductase, putative	0.0086	0.0058	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0064	0.0114
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0136	0.0106	0.019
Plasmodium falciparum	glutathione reductase	0.0086	0.0058	0.0623
Schistosoma mansoni	nAChR subunit	0.0088	0.0061	0.0108
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0064	0.0114
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.003	0.0006	0.0004
Onchocerca volvulus		0.0136	0.0106	0.0183
Schistosoma mansoni	sodium-dependent amino acid transporter	0.1008	0.0931	0.1663
Mycobacterium ulcerans	oxidoreductase	0.0216	0.0181	0.1195
Toxoplasma gondii	NADPH-glutathione reductase	0.003	0.0005	0.0055
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0136	0.0106	0.019
Echinococcus granulosus	neuropeptide Y receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.0028	0.0028
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0216	0.0181	0.0323
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0216	0.0181	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0192	0.0158	0.0283
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Echinococcus multilocularis	serotonin transporter	0.5941	0.5595	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	0.0931
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0217	0.0182	0.1398
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0024	0.0024
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0272	0.0234	0.0234
Brugia malayi	hypothetical protein	0.0216	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.003	0.0006	0.0003
Schistosoma mansoni	sodium/chloride dependent transporter	0.1008	0.0931	0.1663
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.003	0.0006	0.0003
Giardia lamblia	NADH oxidase lateral transfer candidate	0.003	0.0005	0.2412
Plasmodium falciparum	thioredoxin reductase	0.0086	0.0058	0.0623
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0005	0.0005
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0136	0.0106	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0053	0.0028	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Leishmania major	extracellular receptor, putative	0.0053	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Brugia malayi	AKH receptor	0.0136	0.0106	0.0106
Schistosoma mansoni	neuropeptide receptor	0.0136	0.0106	0.019
Brugia malayi	Cytochrome P450 family protein	0.003	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0331	0.029	0.029
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0289	0.025	0.0447
Entamoeba histolytica	hypothetical protein	0.0036	0.0011	0.0874
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.003	0.0006	0.0004
Leishmania major	C-8 sterol isomerase-like protein	1.0599	1	1
Loa Loa (eye worm)	glutamate receptor 2	0.0235	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Echinococcus multilocularis	neuropeptide Y receptor	0.0136	0.0106	0.019
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0216	0.0181	0.1944
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0103	0.0075	0.0134
Brugia malayi	MH2 domain containing protein	0.0258	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0291	0.052
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	G protein coupled receptor 139	0.0136	0.0106	0.019
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0217	0.0182	1
Echinococcus multilocularis	nAChR subunit	0.0192	0.0158	0.0283
Loa Loa (eye worm)	cytochrome P450 family protein	0.0091	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0129	0.0099	0.0178
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1008	0.0931	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0053	0.0028	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0136	0.0106	0.019
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0654	0.0596	0.1065
Loa Loa (eye worm)	LGC-31 protein	0.0192	0.0158	0.0158
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0216	0.0181	0.993
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.034	0.0298	0.0533
Schistosoma mansoni	hypothetical protein	0.0036	0.0011	0.0019
Echinococcus multilocularis	synaptic vesicular amine transporter	0.5326	0.5014	0.8961
Schistosoma mansoni	hypothetical protein	0.0034	0.0009	0.0017
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.003	0.0006	0.0003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0136	0.0106	0.019
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0332	0.0291	0.052
Echinococcus granulosus	tm gpcr rhodopsin	0.3826	0.3595	0.6426
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0195	0.0162	0.1235
Trichomonas vaginalis	glutathione reductase, putative	0.003	0.0005	0.2412
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0192	0.0158	0.0158
Brugia malayi	Cytochrome P450 family protein	0.004	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0172	0.014	0.0914
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0136	0.0106	0.019
Echinococcus granulosus	orexin receptor type 2	0.0136	0.0106	0.019
Treponema pallidum	sodium- and chloride- dependent transporter	0.5941	0.5595	1
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Onchocerca volvulus		0.0136	0.0106	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0136	0.0106	0.019
Echinococcus granulosus	glutamate receptor 2	0.0159	0.0128	0.0228
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0047	0.0021	0.0038
Brugia malayi	Cation transporter family protein	0.0192	0.0158	0.0158
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0136	0.0106	0.019
Echinococcus granulosus	7tm_1 domain containing protein	0.0136	0.0106	0.019
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0136	0.0106	0.019
Schistosoma mansoni	sphingosine kinase A B	0.0155	0.0124	0.0221
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.004	0.0015	0.0066
Echinococcus granulosus	somatostatin receptor	0.0136	0.0106	0.019
Onchocerca volvulus		0.0088	0.0061	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	ACC-1 protein	0.0192	0.0158	0.0158
Toxoplasma gondii	hypothetical protein	0.1008	0.0931	1
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.003	0.0005	0.0009
Brugia malayi	Abnormal catecholamine distribution protein 1	0.5326	0.5014	0.5014
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0136	0.0106	0.0106
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Onchocerca volvulus		0.0136	0.0106	0.0183
Plasmodium falciparum	thioredoxin reductase	0.003	0.0005	0.0055
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0192	0.0158	0.0158
Brugia malayi	SWIRM domain containing protein	0.0701	0.064	0.064
Loa Loa (eye worm)	glutathione reductase	0.0086	0.0058	0.0058
Trypanosoma cruzi	Emopamil binding protein, putative	0.0272	0.0234	0.0234
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0216	0.0181	0.0181
Mycobacterium tuberculosis	Probable oxidoreductase	0.0217	0.0182	0.1398
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0216	0.0181	0.0323
Schistosoma mansoni	tyrosine kinase	0.0053	0.0028	0.0049
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.0086	0.0153
Brugia malayi	sulfakinin receptor protein	0.0136	0.0106	0.0106
Schistosoma mansoni	vesicular acetylcholine transporter	0.0437	0.0391	0.0698
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Leishmania major	cytochrome p450-like protein	0.003	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Onchocerca volvulus		0.0136	0.0106	0.0183
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0192	0.0158	0.0158
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.003	0.0006	0.0004
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0192	0.0158	0.0283
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0136	0.0106	0.0183
Schistosoma mansoni	histamine h1 receptor	0.0136	0.0106	0.019
Echinococcus granulosus	dnaJ subfamily B	0.0399	0.0354	0.0633
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0064	0.0114
Schistosoma mansoni	hypothetical protein	0.0331	0.029	0.0519
Schistosoma mansoni	glutamate receptor kainate	0.0235	0.02	0.0357
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	follicle stimulating hormone receptor	0.0361	0.0318	0.0318
Plasmodium vivax	hypothetical protein, conserved	0.0216	0.0181	0.1944
Loa Loa (eye worm)	ACC-1 protein	0.0192	0.0158	0.0158
Chlamydia trachomatis	glutamine binding protein	0.0172	0.014	0.1453
Brugia malayi	neuropeptide F receptor	0.0136	0.0106	0.0106
Schistosoma mansoni	cpg binding protein	0.0028	0.0004	0.0006
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.003	0.0006	0.0003
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0289	0.025	0.0447
Schistosoma mansoni	amine oxidase	0.0216	0.0181	0.0323
Schistosoma mansoni	neuropeptide F-like receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0088	0.0061	0.0108
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0289	0.025	0.0447
Schistosoma mansoni	vesicular amine transporter	0.5326	0.5014	0.8961
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Schistosoma mansoni	ATP-binding cassette transporter	0.0235	0.02	0.0357
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0064	0.0114
Loa Loa (eye worm)	neuropeptide F receptor	0.0136	0.0106	0.0106
Mycobacterium ulcerans	monoamine oxidase	0.0216	0.0181	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Giardia lamblia	hypothetical protein	0.0047	0.0021	1
Loa Loa (eye worm)	hypothetical protein	0.5941	0.5595	0.5595
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.003	0.0006	0.0003
Echinococcus granulosus	cpg binding protein	0.003	0.0005	0.0009
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0004	0.0004
Mycobacterium tuberculosis	Possible oxidoreductase	0.0216	0.0181	0.1388
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0103	0.0075	0.0075
Schistosoma mansoni	neurotransmitter gated ion channel	0.0088	0.0061	0.0108
Trypanosoma cruzi	C-8 sterol isomerase, putative	1.0599	1	1
Onchocerca volvulus		0.0053	0.0028	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Toxoplasma gondii	thioredoxin reductase	0.0086	0.0058	0.0623
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0192	0.0158	0.0283
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0053	0.0028	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0291	0.052
Brugia malayi	Receptor family ligand binding region containing protein	0.0053	0.0028	0.0028
Echinococcus granulosus	neuropeptides capa receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0136	0.0106	0.019
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0136	0.0106	0.019
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Schistosoma mansoni	opsin-like receptor	0.0136	0.0106	0.019
Onchocerca volvulus		0.0136	0.0106	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0654	0.0596	0.0596
Brugia malayi	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus granulosus	sodium and chloride dependent glycine	0.1008	0.0931	0.1663
Echinococcus granulosus	biogenic amine 5HT receptor	0.0383	0.034	0.0607
Onchocerca volvulus		0.0088	0.0061	0.0102
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0172	0.014	0.0241
Onchocerca volvulus		0.0192	0.0158	0.0277
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0437	0.0391	0.0391
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0383	0.034	0.0607
Brugia malayi	putative neuropeptide receptor	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	Cytochrome P450 family protein	0.0091	0.0064	0.0064
Mycobacterium tuberculosis	Probable dehydrogenase	0.0195	0.0162	0.1235
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0053	0.0028	0.0028
Loa Loa (eye worm)	solute carrier family 6 member 4	0.5941	0.5595	0.5595
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0009	0.4189
Echinococcus granulosus	nAChR subunit	0.0192	0.0158	0.0283
Plasmodium vivax	thioredoxin reductase, putative	0.0086	0.0058	0.0623
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0136	0.0106	0.0106
Plasmodium vivax	amine transporter, putative	0.1008	0.0931	1
Onchocerca volvulus		0.034	0.0298	0.0527
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	0.0931
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.003	0.0005	0.0055
Echinococcus multilocularis	g-protein coupled receptor	0.0136	0.0106	0.019
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.003	0.0006	0.0003
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0192	0.0158	0.0158
Echinococcus multilocularis	neuropeptide receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.003	0.0006	0.0004
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0024	0.0024
Echinococcus multilocularis	geminin	0.0524	0.0473	0.0845
Schistosoma mansoni	neuropeptide F-like receptor	0.0136	0.0106	0.019
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0088	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0524	0.0473	0.0845
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0172	0.014	0.1453
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0136	0.0106	0.0106
Echinococcus multilocularis	orexin receptor type 2	0.0136	0.0106	0.019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0014	0.0025
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0136	0.0106	0.019
Schistosoma mansoni	opsin-like receptor	0.0136	0.0106	0.019
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0216	0.0181	0.1195
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0192	0.0158	0.0283
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1585	0.1476	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.003	0.0006	0.0004
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0167	0.0135	0.0135
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	Squalene phytoene synthase	0.0331	0.029	0.0519
Onchocerca volvulus		0.1008	0.0931	0.1658
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0129	0.0099	0.0178
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0332	0.0291	0.052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Onchocerca volvulus	Putative nachr subunit	0.0332	0.0291	0.0514
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	ORL1-like opioid receptor	0.0136	0.0106	0.0106
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0437	0.0391	0.0693
Brugia malayi	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus multilocularis	sphingosine kinase 1	0.0155	0.0124	0.0221
Echinococcus multilocularis	glutamate receptor 2	0.0289	0.025	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0172	0.014	0.014
Echinococcus multilocularis		0.003	0.0006	0.001
Schistosoma mansoni	neuropeptide receptor	0.0136	0.0106	0.019
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0005	0.0005
Echinococcus granulosus	sodium and chloride dependent glycine	0.1008	0.0931	0.1663
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0053	0.0028	0.0049
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1008	0.0931	0.1663
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.003	0.0005	0.0055
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0136	0.0106	0.019
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.003	0.0006	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.003	0.0006	0.0003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0024	0.0024
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.003	0.0006	0.0003
Onchocerca volvulus		0.0136	0.0106	0.0183
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.003	0.0006	0.0003
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.003	0.0006	0.0006
Echinococcus granulosus	thioredoxin glutathione reductase	0.0086	0.0058	0.0104
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.003	0.0006	0.0004
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.003	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	cytochrome P450	0.003	0.0006	0.0006
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0005	0.0005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0064	0.0114
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0192	0.0158	0.0158
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	SWI/SNF complex-related	0.0047	0.0021	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0047	0.0021	0.0038
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0136	0.0106	0.019
Plasmodium vivax	hypothetical protein, conserved	0.1008	0.0931	1
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0088	0.0061	0.0108
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Schistosoma mansoni	amine GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0192	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.034	0.0298	0.0298
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.003	0.0006	0.0004
Echinococcus granulosus	sex peptide receptor	0.0136	0.0106	0.019
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0172	0.014	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0701	0.064	0.064
Brugia malayi	hypothetical protein	0.1008	0.0931	0.0931
Echinococcus multilocularis	fmrfamide receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	nmda type glutamate receptor	0.0133	0.0103	0.0184
Echinococcus multilocularis	fmrfamide receptor	0.0136	0.0106	0.019
Trypanosoma cruzi	Emopamil binding protein, putative	0.0272	0.0234	0.0234
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.5324	0.5012	0.5012
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0331	0.029	0.1939
Echinococcus granulosus	g protein coupled receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	zinc finger protein	0.0316	0.0276	0.0276
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0124	0.0124
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0192	0.0158	0.0283
Onchocerca volvulus		0.0053	0.0028	0.0043
Schistosoma mansoni	opsin-like receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	GABA receptor subunit	0.0103	0.0075	0.0075
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.137	0.1272	1
Echinococcus granulosus	synaptic vesicular amine transporter	0.5326	0.5014	0.8961
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0136	0.0106	0.019
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0217	0.0182	0.1398
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0192	0.0158	0.0158
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.003	0.0005	0.0009
Echinococcus granulosus	nAChR subunit	0.0103	0.0075	0.0134
Echinococcus granulosus	nmda type glutamate receptor	0.0133	0.0103	0.0184
Brugia malayi	hypothetical protein	0.0053	0.0028	0.0028
Entamoeba histolytica	hypothetical protein	0.0036	0.0011	0.0874
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.003	0.0006	0.0003
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.003	0.0005	0.0005
Brugia malayi	Dopamine receptor protein 1	0.056	0.0506	0.0506
Onchocerca volvulus		0.0088	0.0061	0.0102
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0129	0.0099	0.0178
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1008	0.0931	0.1663
Onchocerca volvulus		0.0136	0.0106	0.0183
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0103	0.0075	0.0075
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0088	0.0061	0.0061
Brugia malayi	Dopamine receptor protein 2	0.0136	0.0106	0.0106
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0192	0.0158	0.0158
Echinococcus granulosus	receptor type guanylyl cyclase	0.0053	0.0028	0.0049
Onchocerca volvulus		0.0103	0.0075	0.0127
Echinococcus granulosus	zinc finger transcription factor gli2	0.0316	0.0276	0.0493
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0053	0.0028	0.0049
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0015	0.0015
Echinococcus granulosus	sphingosine kinase 1	0.0155	0.0124	0.0221
Brugia malayi	hypothetical protein	0.0088	0.0061	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	neuropeptide f receptor 76f	0.0136	0.0106	0.019
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0272	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.005	0.0024	0.0024
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0289	0.025	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Brugia malayi	Thioredoxin reductase	0.0086	0.0058	0.0058
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.3826	0.3595	0.6426
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Echinococcus granulosus	g-protein coupled receptor	0.0136	0.0106	0.019
Echinococcus granulosus	fmrfamide receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	NMDA receptor	0.0129	0.0099	0.0178
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0515	0.0464	0.083
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0088	0.0061	0.0108
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0053	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Echinococcus multilocularis	nAChR subunit	0.0103	0.0075	0.0134
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0332	0.0291	0.052
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0332	0.0291	0.052
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.003	0.0006	0.0003
Toxoplasma gondii	cytochrome p450 superfamily protein	0.003	0.0006	0.006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0064	0.0114
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0086	0.0058	0.0104
Loa Loa (eye worm)	glutamate receptor	0.0053	0.0028	0.0028
Trypanosoma cruzi	squalene synthase, putative	0.1063	0.0982	0.0982
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	biogenic amine receptor	0.0136	0.0106	0.019
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0129	0.0099	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Loa Loa (eye worm)	norepinephrine transporter	0.5941	0.5595	0.5595
Trypanosoma cruzi	extracellular receptor, putative	0.0053	0.0028	0.0028
Schistosoma mansoni	biogenic amine receptor	0.0136	0.0106	0.019
Schistosoma mansoni	sodium/chloride dependent transporter	0.1008	0.0931	0.1663
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0136	0.0106	0.019
Brugia malayi	excitatory GABA receptor EXP-1A	0.0192	0.0158	0.0158
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Onchocerca volvulus		0.0136	0.0106	0.0183
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0192	0.0158	0.0158
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus granulosus	7TM GPCR rhodopsin	0.0136	0.0106	0.019
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0136	0.0106	0.0106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0262	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.003	0.0006	0.0004
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.1008	0.0931	0.1663
Schistosoma mansoni	amine GPCR	0.0136	0.0106	0.019
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.1008	0.0931	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0136	0.0106	0.019
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.003	0.0006	0.0004
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0011	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0088	0.0061	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0136	0.0106	0.019
Schistosoma mansoni	growth hormone secretagogue receptor	0.0136	0.0106	0.019
Echinococcus granulosus	g protein coupled receptor	0.0136	0.0106	0.019
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.003	0.0006	0.0004
Echinococcus granulosus	biogenic amine 5HT receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0053	0.0028	0.0028
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.003	0.0006	0.0003
Plasmodium falciparum	glutathione reductase	0.003	0.0005	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0383	0.034	0.034
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0195	0.0162	0.8834
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0015	0.0015
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0172	0.014	0.0241
Echinococcus multilocularis	cpg binding protein	0.003	0.0005	0.0009
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0192	0.0158	0.0158
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0011	0.0011
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0053	0.0028	0.0049
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0136	0.0106	0.0106
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0291	0.0291
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0006	0.0006
Schistosoma mansoni	amine oxidase	0.0216	0.0181	0.0323
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Echinococcus multilocularis	g protein coupled receptor	0.0136	0.0106	0.019
Onchocerca volvulus		0.034	0.0298	0.0527
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.5941	0.5595	0.5595
Echinococcus granulosus	neuropeptide FF receptor 2	0.0136	0.0106	0.019
Echinococcus multilocularis	serotonin receptor	0.0383	0.034	0.0607
Schistosoma mansoni	neurotransmitter gated ion channel	0.0103	0.0075	0.0134
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0289	0.025	0.0447
Echinococcus multilocularis	g protein coupled receptor	0.0136	0.0106	0.019
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus granulosus	allatostatin A receptor	0.0136	0.0106	0.019
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0129	0.0099	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Schistosoma mansoni	hypothetical protein	0.0136	0.0106	0.019
Schistosoma mansoni	hypothetical protein	0.0136	0.0106	0.019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Trichomonas vaginalis	mercuric reductase, putative	0.003	0.0005	0.2412
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Schistosoma mansoni	cpg binding protein	0.003	0.0005	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Echinococcus granulosus	G protein coupled receptor 139	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0251	0.0215	0.0215
Schistosoma mansoni	amine GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	cytochrome P450	0.003	0.0006	0.001
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.003	0.0006	0.0004
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0011	0.0011
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.1008	0.0931	0.0931
Echinococcus multilocularis	glycine receptor subunit beta	0.0192	0.0158	0.0283
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0216	0.0181	0.1944
Echinococcus granulosus	neuropeptide receptor	0.0136	0.0106	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	acetylcholine receptor protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0192	0.0158	0.0158
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0654	0.0596	0.1065
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.003	0.0005	0.0055
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.003	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.003	0.0005	0.0005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0136	0.0106	0.019
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0011	0.002
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0136	0.0106	0.019
Echinococcus granulosus	glycine receptor subunit beta	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Mycobacterium ulcerans	dehydrogenase	0.0216	0.0181	0.1195
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0136	0.0106	0.0106
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Schistosoma mansoni	hypothetical protein	0.0136	0.0106	0.019
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.003	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	glutamate receptor AMPA	0.0235	0.02	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0136	0.0106	0.0106
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.003	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.5941	0.5595	0.5595
Loa Loa (eye worm)	thioredoxin reductase	0.0086	0.0058	0.0058
Echinococcus multilocularis	sodium and chloride dependent glycine	0.1008	0.0931	0.1663
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Trypanosoma cruzi	phytoene synthase, putative	0.0331	0.029	0.029
Brugia malayi	hypothetical protein	0.0036	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.056	0.0506	0.0506
Echinococcus multilocularis	neuropeptide Y receptor	0.0136	0.0106	0.019
Schistosoma mansoni	tyrosine kinase	0.0053	0.0028	0.0049
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	MH2 domain-containing protein	0.0258	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	1.0599	1	1
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.003	0.0006	0.0006
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0053	0.0028	0.0049
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus granulosus	serotonin transporter	0.5941	0.5595	1
Onchocerca volvulus		0.1008	0.0931	0.1658
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus granulosus	glutamate receptor 2	0.0289	0.025	0.0447
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.003	0.0006	0.0003
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.003	0.0005	0.0055
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0009	0.0009
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0361	0.0318	0.0318
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0192	0.0158	0.0283
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0088	0.0061	0.0061
Loa Loa (eye worm)	G-protein coupled receptor	0.0136	0.0106	0.0106
Entamoeba histolytica	hypothetical protein	0.0047	0.0021	0.1707
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.003	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0216	0.0181	0.0181
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	Zinc finger, C2H2 type family protein	0.0316	0.0276	0.0276
Schistosoma mansoni	lipoxygenase	0.008	0.0053	0.0095
Schistosoma mansoni	sodium/chloride dependent transporter	0.5941	0.5595	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0064	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0216	0.0181	0.19
Echinococcus multilocularis	dro:myosuppressin receptor	0.0136	0.0106	0.019
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0192	0.0158	0.0283
Brugia malayi	G-protein coupled receptor	0.0136	0.0106	0.0106
Mycobacterium ulcerans	hypothetical protein	0.0155	0.0124	0.0805
Echinococcus granulosus	vesicular acetylcholine transporter	0.0437	0.0391	0.0698
Schistosoma mansoni	hypothetical protein	0.0399	0.0354	0.0633
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0289	0.025	0.0447
Loa Loa (eye worm)	hypothetical protein	0.5941	0.5595	0.5595
Echinococcus granulosus	glycine receptor subunit beta	0.0192	0.0158	0.0283
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus granulosus	hypothetical protein	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0027	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	RE15519p	0.0136	0.0106	0.0106
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0088	0.0061	0.0061
Trypanosoma brucei	squalene synthase, putative	0.1063	0.0982	0.0982
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.003	0.0006	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	dnaJ subfamily B	0.0399	0.0354	0.0633
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0136	0.0106	0.019
Onchocerca volvulus		0.5941	0.5595	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0088	0.0061	0.0061
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0011	0.0019
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0136	0.0106	0.019
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0006	0.0006
Leishmania major	cytochrome p450-like protein	0.004	0.0015	0.0015
Onchocerca volvulus		0.0136	0.0106	0.0183
Loa Loa (eye worm)	G-protein coupled receptor	0.0136	0.0106	0.0106
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0192	0.0158	0.0283
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0103	0.0075	0.0134
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0053	0.0028	0.0049
Schistosoma mansoni	neuropeptide receptor	0.0136	0.0106	0.019
Brugia malayi	Glutamate receptor 1 precursor	0.0235	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Echinococcus multilocularis	sex peptide receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Leishmania major	cytochrome p450-like protein	0.003	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	acetylcholine receptor-related	0.0088	0.0061	0.0108
Trypanosoma brucei	trypanothione reductase	0.0086	0.0058	0.0058
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.003	0.0005	0.0009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0011	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1008	0.0931	0.1663
Echinococcus granulosus	geminin	0.0524	0.0473	0.0845
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.003	0.0006	0.0004
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0064	0.0064
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0383	0.034	0.034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0192	0.0158	0.0158
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0195	0.0162	0.1235
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0009	0.4189
Plasmodium falciparum	protoporphyrinogen oxidase	0.0216	0.0181	0.1944
Echinococcus multilocularis	glycine receptor subunit beta	0.0192	0.0158	0.0283
Onchocerca volvulus		0.0103	0.0075	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Schistosoma mansoni	hypothetical protein	0.003	0.0006	0.001
Echinococcus granulosus	neuropeptide Y receptor	0.0136	0.0106	0.019
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0136	0.0106	0.019
Trypanosoma cruzi	cytochrome P450, putative	0.004	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.003	0.0006	0.0004
Echinococcus granulosus	dro:myosuppressin receptor	0.0136	0.0106	0.019
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0005	0.0005
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	larval opioid receptor	0.0136	0.0106	0.0106
Brugia malayi	Cation transporter family protein	0.034	0.0298	0.0298
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0216	0.0181	0.1388
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	protein kinase	0.0053	0.0028	0.0049
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0053	0.0028	0.0049
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.1008	0.0931	0.1663
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0192	0.0158	0.0158
Onchocerca volvulus		0.0192	0.0158	0.0277
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0129	0.0099	0.0178
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0195	0.0162	0.1235
Echinococcus multilocularis	glutamate receptor 2	0.0235	0.02	0.0357
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0136	0.0106	0.019
Onchocerca volvulus		0.0136	0.0106	0.0183
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.003	0.0006	0.0003
Entamoeba histolytica	hypothetical protein	0.0103	0.0075	0.6051
Onchocerca volvulus	CoRest homolog	0.0172	0.014	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0009	0.0009
Loa Loa (eye worm)	CYP4Cod1	0.004	0.0015	0.0015
Echinococcus granulosus	cytochrome P450 2K1	0.003	0.0006	0.001
Plasmodium vivax	hypothetical protein, conserved	0.0216	0.0181	0.1944
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.003	0.0006	0.0006
Echinococcus multilocularis	glutamate receptor NMDA	0.008	0.0052	0.0094
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0005	0.5
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0216	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0136	0.0106	0.0106
Brugia malayi	putative neuropeptide receptor NPR1	0.0136	0.0106	0.0106
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0136	0.0106	0.019
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.5326	0.5014	0.5014
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.0015	0.0015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0136	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0088	0.0061	0.0061
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.5941	0.5595	1
Echinococcus multilocularis		0.0216	0.0181	0.0323
Echinococcus multilocularis	somatostatin receptor	0.0136	0.0106	0.019
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0289	0.025	0.0447
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0136	0.0106	0.019
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	1
Entamoeba histolytica	hypothetical protein	0.0053	0.0028	0.2236
Trypanosoma cruzi	squalene synthase, putative	0.1063	0.0982	0.0982
Echinococcus multilocularis	neuropeptide s receptor	0.0136	0.0106	0.019
Brugia malayi	Serotonin receptor	0.0607	0.0551	0.0551
Plasmodium falciparum	amino acid transporter, putative	0.1008	0.0931	1
Schistosoma mansoni	nAChR subunit	0.0088	0.0061	0.0108
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0192	0.0158	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	Guanylyl cyclase protein 23	0.0053	0.0028	0.0028
Echinococcus granulosus	neuropeptide receptor A26	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Trypanosoma brucei	C-8 sterol isomerase, putative	1.0599	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0136	0.0106	0.019
Schistosoma mansoni	amine GPCR	0.0136	0.0106	0.019
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0216	0.0181	0.1944
Schistosoma mansoni	cpg binding protein	0.003	0.0005	0.0009
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0088	0.0061	0.0108
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0217	0.0183	0.1962
Onchocerca volvulus		0.034	0.0298	0.0527
Schistosoma mansoni	metabotropic glutamate receptor	0.0053	0.0028	0.0049
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.1008	0.0931	0.1663
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0103	0.0075	0.0075
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0005	0.0005
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.003	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Onchocerca volvulus		0.0272	0.0234	0.0412
Schistosoma mansoni	amine GPCR	0.0136	0.0106	0.019
Leishmania major	trypanothione reductase	0.0086	0.0058	0.0058
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.003	0.0006	0.0003
Schistosoma mansoni	myosin xvIII	0.0136	0.0106	0.019
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	0.0931
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0005	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0192	0.0158	0.0283
Brugia malayi	Receptor family ligand binding region containing protein	0.0053	0.0028	0.0028
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Loa Loa (eye worm)	cytochrome P450	0.003	0.0006	0.0006
Mycobacterium tuberculosis	Conserved protein	0.0155	0.0124	0.0935
Trypanosoma brucei	cytochrome P450, putative	0.004	0.0015	0.0015
Entamoeba histolytica	SWIRM domain protein	0.0047	0.0021	0.1707
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Toxoplasma gondii	histone lysine-specific demethylase	0.0216	0.0181	0.1944
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0331	0.029	0.2251
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0515	0.0464	0.083
Schistosoma mansoni	sphingoid long chain base kinase	0.0155	0.0124	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Schistosoma mansoni	neurotransmitter gated ion channel	0.0088	0.0061	0.0108
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0291	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0021	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Brugia malayi	glutathione reductase	0.0086	0.0058	0.0058
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0654	0.0596	0.1065
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0136	0.0106	0.019
Brugia malayi	amine oxidase, flavin-containing family protein	0.0262	0.0225	0.0225
Brugia malayi	Cation transporter family protein	0.0192	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Mycobacterium tuberculosis	Probable reductase	0.0195	0.0162	0.1235
Toxoplasma gondii	SWIRM domain-containing protein	0.0047	0.0021	0.0227
Echinococcus multilocularis	g protein coupled receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	neuropeptide F receptor	0.0136	0.0106	0.0106
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0136	0.0106	0.0183
Schistosoma mansoni	glutamate receptor NMDA	0.0368	0.0325	0.0582
Echinococcus multilocularis	neuropeptide receptor A26	0.0136	0.0106	0.019
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0088	0.0061	0.0108
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0437	0.0391	0.0391
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.1008	0.0931	0.0931
Echinococcus multilocularis	serotonin receptor	0.0383	0.034	0.0607
Schistosoma mansoni	lipoxygenase	0.0115	0.0086	0.0153
Echinococcus granulosus	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.1008	0.0931	0.0931
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	zinc finger transcription factor gli2	0.0316	0.0276	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Brugia malayi	G protein-coupled receptor	0.0136	0.0106	0.0106
Onchocerca volvulus		0.0136	0.0106	0.0183
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0289	0.025	0.0447
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0136	0.0106	0.019
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0332	0.0291	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0654	0.0596	0.0596
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0005	0.0005
Onchocerca volvulus		0.1008	0.0931	0.1658
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0053	0.0028	0.0028
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0192	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Onchocerca volvulus		0.0192	0.0158	0.0277
Brugia malayi	SWIRM domain containing protein	0.0047	0.0021	0.0021
Brugia malayi	Dopamine receptor	0.0136	0.0106	0.0106
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Echinococcus multilocularis	neuropeptides capa receptor	0.0136	0.0106	0.019
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Echinococcus multilocularis	glutamate receptor 2	0.0159	0.0128	0.0228
Echinococcus granulosus	nmda type glutamate receptor	0.0381	0.0337	0.0603
Echinococcus granulosus	Squalene phytoene synthase	0.0331	0.029	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	neuropeptide receptor	0.0136	0.0106	0.019
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0061	0.0061
Echinococcus granulosus	tyrosine kinase	0.0053	0.0028	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0136	0.0106	0.019
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.0086	0.0153
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0331	0.029	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0075	0.0075
Brugia malayi	Melatonin receptor type 1A	0.0136	0.0106	0.0106
Schistosoma mansoni	metabotropic glutamate receptor	0.0053	0.0028	0.0049
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.003	0.0005	0.0005
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0136	0.0106	0.0106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0064	0.0114
Loa Loa (eye worm)	TYRA-2 protein	0.0136	0.0106	0.0106
Echinococcus granulosus	g protein coupled receptor	0.0136	0.0106	0.019
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	glutamate receptor kainate	0.0235	0.02	0.0357
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.003	0.0005	0.0005
Toxoplasma gondii	hypothetical protein	0.1008	0.0931	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1008	0.0931	0.1663
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Leishmania major	hypothetical protein, conserved	0.0331	0.029	0.029
Schistosoma mansoni	hypothetical protein	0.0136	0.0106	0.019
Echinococcus granulosus	neuropeptide receptor	0.0136	0.0106	0.019
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0033	0.0059
Schistosoma mansoni	adenoreceptor	0.0136	0.0106	0.019
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0129	0.0099	0.0178
Trypanosoma brucei	Emopamil binding protein, putative	0.0272	0.0234	0.0234
Loa Loa (eye worm)	hypothetical protein	0.034	0.0298	0.0298
Schistosoma mansoni	glutamate receptor kainate	0.0235	0.02	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0216	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0158	0.0158
Brugia malayi	hypothetical protein	0.0136	0.0106	0.0106
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.003	0.0006	0.0004
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1585	0.1476	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0136	0.0106	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0136	0.0106	0.019
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.003	0.0005	0.0055
Echinococcus granulosus	glutamate receptor NMDA	0.008	0.0052	0.0094
Loa Loa (eye worm)	glutamate receptor 1	0.0235	0.02	0.02
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0301	0.0262	0.0468
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0216	0.0181	0.1944
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0192	0.0158	0.0283
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0129	0.0099	0.0178
Schistosoma mansoni	nAChR subunit	0.0192	0.0158	0.0283
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.003	0.0006	0.0003
Echinococcus granulosus	neuropeptide s receptor	0.0136	0.0106	0.019
Entamoeba histolytica	SWIRM domain protein	0.0047	0.0021	0.1707
Echinococcus multilocularis	tyrosine kinase	0.0053	0.0028	0.0049
Entamoeba histolytica	hypothetical protein	0.0036	0.0011	0.0874
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.003	0.0006	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0136	0.0106	0.019
Brugia malayi	Glutamate receptor 2 precursor	0.0235	0.02	0.02
Onchocerca volvulus		0.0701	0.064	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0028	0.0028
Loa Loa (eye worm)	serotonin transporter b	0.5941	0.5595	0.5595
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0437	0.0391	0.0698
Echinococcus multilocularis	allatostatin A receptor	0.0136	0.0106	0.019
Brugia malayi	G-protein coupled receptor	0.0136	0.0106	0.0106
Plasmodium vivax	glutathione reductase, putative	0.0086	0.0058	0.0623
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.003	0.0006	0.0003
Brugia malayi	metabotropic glutamate receptor type 2	0.0053	0.0028	0.0028
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.1008	0.0931	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0136	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.0524	0.0473	0.0845
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0136	0.0106	0.019
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0136	0.0106	0.019
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0021	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 2 %	Inhibition of AP1 expressed in HEK293 cells assessed as inhibition of TNF-alpha-induced transcriptional activation at 10 uM treated 24 hrs before TNFalpha challenge measured after 20 to 24 hrs by luciferase assay relative to control	ChEMBL.	19064304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL487552

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 987621