Detailed information for compound 1063240

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.477 | Formula: C20H21N5O3S
  • H donors: 2 H acceptors: 4 LogP: 2.64 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCNC(=O)NC(=O)CSc1nc2ccccc2c(=O)n1Cc1ccncc1
  • InChi: 1S/C20H21N5O3S/c1-2-9-22-19(28)24-17(26)13-29-20-23-16-6-4-3-5-15(16)18(27)25(20)12-14-7-10-21-11-8-14/h3-8,10-11H,2,9,12-13H2,1H3,(H2,22,24,26,28)
  • InChiKey: JPMCAJIGCBHQDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0031 0.0029 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0063 0.0113 0.239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0219 0.0522 0.3749
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0353 0.0875 0.9287
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0008 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.013 0.013
Brugia malayi Heterochromatin protein 1 0.0081 0.016 0.1106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.002 0.0393
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.039
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0368 0.0913 0.2486
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0379 0.0942 0.2722
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0063 0.0113 0.239
Giardia lamblia Phosphoglycerate kinase 0.0197 0.0465 0.4897
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0913 0.6604
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.024
Echinococcus multilocularis zinc finger protein 0.0023 0.0008 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0065 0.0612
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0403 0.1005 0.1005
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0141 0.0318 0.2262
Entamoeba histolytica hypothetical protein 0.008 0.0159 0.1101
Onchocerca volvulus 0.008 0.0159 0.6466
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0063 0.0113 0.239
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0102 0.0216 0.2227
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0063 0.0113 0.239
Echinococcus multilocularis expressed protein 0.0039 0.005 0.005
Echinococcus granulosus bloom syndrome protein 0.0023 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.009 0.0598
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0138 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.005 0.0301
Trichomonas vaginalis rotamase, putative 0.0039 0.005 0.0301
Onchocerca volvulus 0.008 0.0159 0.6466
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0017 0.0082
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0545 0.1378 0.3995
Trichomonas vaginalis rotamase, putative 0.0038 0.0047 0.0284
Trypanosoma brucei phosphoglycerate kinase 0.0072 0.0138 0.1389
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0065 0.137
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0017 0.0017
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.008 0.0159 0.1101
Loa Loa (eye worm) hypothetical protein 0.0142 0.032 0.1869
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0047 0.0107
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0749 0.1913 0.1913
Echinococcus multilocularis 0.0063 0.0113 0.0113
Schistosoma mansoni cytochrome P450 0.0063 0.0113 0.0551
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0065 0.0417
Giardia lamblia DINP protein human, muc B family 0.0045 0.0065 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0159 0.1101
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0136 0.0306 0.0868
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0063 0.0113 0.239
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0098 0.0205 0.0572
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.002 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0063 0.0113 0.239
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0235 0.0623
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0062 0.0156
Toxoplasma gondii FATC domain-containing protein 0.0219 0.0522 0.5723
Mycobacterium ulcerans phosphoglycerate kinase 0.0197 0.0465 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.0885 0.6397
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0545 0.1378 1
Loa Loa (eye worm) cytochrome P450 0.0063 0.0113 0.0658
Loa Loa (eye worm) hypothetical protein 0.0058 0.01 0.0581
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0118
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0065 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0913 0.6604
Leishmania major phosphatidylinositol kinase, putative 0.008 0.0159 0.0414
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0378
Trypanosoma brucei phosphoglycerate kinase 0.0197 0.0465 0.4897
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0032 0.0174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0078 0.0454
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0063 0.0113 0.239
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.0159 0.1101
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0159 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6344
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.044
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0063 0.0113 0.239
Schistosoma mansoni hypothetical protein 0.008 0.0159 0.0779
Schistosoma mansoni hypothetical protein 0.0098 0.0205 0.1002
Onchocerca volvulus 0.0035 0.0041 0.0976
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0053
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0159 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0219 0.0522 0.3749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6343
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0214 0.051 0.3661
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6344
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0219 0.0522 0.5504
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0379 0.0942 0.6813
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0403 0.1005 0.2907
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0113 0.0304
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0429 0.1074 0.7777
Plasmodium falciparum phosphoglycerate kinase 0.0197 0.0465 1
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0086
Echinococcus multilocularis phosphoglycerate kinase 1 0.0197 0.0465 0.0465
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0065 0.137
Brugia malayi Cytochrome P450 family protein 0.0094 0.0194 0.1357
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0063 0.0113 0.239
Entamoeba histolytica phosphoglycerate kinase, putative 0.0197 0.0465 0.3336
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0011 0.0063
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0545 0.1378 1
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0188 0.0442 0.0442
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0008 0.0138
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0142 0.032 0.032
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0063 0.0113 0.239
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0217 0.0517 0.3712
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0379 0.0942 0.2564
Leishmania major phosphatidylinositol 3-kinase, putative 0.0141 0.0318 0.0851
Loa Loa (eye worm) cytochrome P450 family protein 0.0094 0.0194 0.1133
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0197 0.0465 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0008 0.0049
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0217 0.0517 0.5449
Loa Loa (eye worm) cytochrome P450 family protein 0.0094 0.0194 0.1133
Loa Loa (eye worm) hypothetical protein 0.0222 0.0532 0.31
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0942 0.6813
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.01 0.0666
Mycobacterium leprae Conserved hypothetical protein 0.0063 0.0113 0.2079
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0063 0.0113 0.239
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0052 0.0316
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0141 0.0318 0.1556
Trypanosoma brucei unspecified product 0.0045 0.0065 0.0612
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.008 0.0159 0.1101
Echinococcus granulosus serine protein kinase ATM 0.0219 0.0522 0.0522
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0333 0.0821 0.5936
Schistosoma mansoni bromodomain containing protein 0.0073 0.014 0.0687
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0235 0.0235
Schistosoma mansoni chromobox protein 0.0081 0.016 0.0782
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0545 0.1378 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0063 0.0113 0.239
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0343 0.0849 0.9007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0063 0.0113 0.0304
Echinococcus granulosus microtubule associated protein 2 0.0799 0.2045 0.2045
Loa Loa (eye worm) hypothetical protein 0.0333 0.0821 0.479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Leishmania major hypothetical protein, unknown function 0.008 0.0159 0.0414
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0141 0.0318 0.2262
Loa Loa (eye worm) phosphatidylinositol kinase 0.008 0.0159 0.0929
Schistosoma mansoni kinase 0.0056 0.0094 0.046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.0477 0.3418
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0235 0.0235
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0188 0.0442 0.0442
Echinococcus multilocularis chromobox protein 1 0.0081 0.016 0.016
Trypanosoma brucei unspecified product 0.0031 0.0029 0.0221
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.008 0.0159 0.1101
Loa Loa (eye worm) hypothetical protein 0.008 0.0159 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6343
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.002 0.0393
Schistosoma mansoni DNA helicase recq1 0.0023 0.0008 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.013 0.013
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0076 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Brugia malayi chromobox protein homolog 3 0.0045 0.0067 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0188 0.1309
Leishmania major DNA polymerase eta, putative 0.0043 0.0062 0.0147
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0217 0.0517 0.3712
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.016 0.0932
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0217 0.0517 0.3712
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0545 0.1378 1
Brugia malayi cytochrome P450 0.0063 0.0113 0.0762
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0379 0.0942 0.6813
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0086
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0063 0.0113 0.239
Plasmodium vivax hypothetical protein, conserved 0.008 0.0159 0.3393
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0318 0.3321
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.01 0.0581
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0008 0.0138
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.002 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0136 0.0306 0.1784
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.005 0.029
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0076 0.2588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0533 0.3834
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0063 0.0113 0.239
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.005 0.0301
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0141 0.0318 0.2262
Brugia malayi FAT domain containing protein 0.0142 0.032 0.2278
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0063 0.0113 0.1118
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0094 0.0194 0.4149
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0063 0.0113 0.239
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0063 0.0113 0.239
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0063 0.0113 0.239
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0333 0.0821 0.0821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0913 0.6604
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0235 0.115
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0141 0.0318 0.6826
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0379 0.0942 0.2564
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.0143 0.0392
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0057 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.009 0.0598
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0379 0.0942 0.6813
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0219 0.0522 0.2552
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0159 0.0929
Brugia malayi Cytochrome P450 family protein 0.0094 0.0194 0.1357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.0159 0.1101
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.002 0.0393
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.008 0.0159 0.044
Echinococcus granulosus expressed protein 0.0039 0.005 0.005
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0063 0.0113 0.239
Brugia malayi Cytochrome P450 family protein 0.0063 0.0113 0.0762
Trypanosoma brucei cytochrome P450, putative 0.0094 0.0194 0.1992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6343
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0118
Echinococcus granulosus intestinal type alkaline phosphatase 0.0188 0.0442 0.0442
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0058 0.036
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0201 0.0477 0.0477
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0749 0.1913 0.1913
Echinococcus granulosus dna polymerase kappa 0.0045 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.008 0.0159 0.1101
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0067 0.2169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.002 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0065 0.137
Loa Loa (eye worm) hypothetical protein 0.0197 0.0465 0.2714
Schistosoma mansoni rotamase 0.0039 0.005 0.0243
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Trichomonas vaginalis chromobox protein, putative 0.0081 0.016 0.1106
Treponema pallidum phosphoglycerate kinase 0.0197 0.0465 0.5
Schistosoma mansoni DNA polymerase eta 0.0074 0.0143 0.0699
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0063 0.0113 0.239
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0393
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0318 0.0904
Echinococcus multilocularis microtubule associated protein 2 0.0799 0.2045 0.2045
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0065 0.0065
Giardia lamblia Hypothetical protein 0.008 0.0159 0.1616
Toxoplasma gondii target of rapamycin (TOR), putative 0.0365 0.0906 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0197 0.0465 0.3336
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0047 0.0433
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0063 0.0113 0.239
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0086
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0403 0.1005 0.4914
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0067 0.0427
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0197 0.0465 0.1333
Mycobacterium leprae conserved hypothetical protein 0.008 0.0159 0.3123
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0204 0.0483 0.3468
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Echinococcus granulosus dna polymerase eta 0.0074 0.0143 0.0143
Schistosoma mansoni DNA helicase recq5 0.0023 0.0008 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.008 0.0159 0.0159
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0063 0.0113 0.239
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0141 0.0318 0.2262
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0429 0.1074 0.7777
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0141 0.0318 0.6826
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0217 0.0517 0.3712
Echinococcus multilocularis alkaline phosphatase 0.0188 0.0442 0.0442
Echinococcus multilocularis 0.008 0.0159 0.0159
Trichomonas vaginalis chromobox protein, putative 0.0081 0.016 0.1106
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.008 0.0159 0.0779
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0065 0.0166
Mycobacterium leprae putative cytochrome p450 0.0063 0.0113 0.2079
Loa Loa (eye worm) hypothetical protein 0.0074 0.0143 0.0833
Loa Loa (eye worm) hypothetical protein 0.0212 0.0505 0.2944
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0002 0.0011
Schistosoma mansoni chromobox protein 0.0081 0.016 0.0782
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3832 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.0143 0.0982
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0065 0.0382
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0379 0.0942 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0063 0.0113 0.239
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0545 0.1378 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0393
Leishmania major cytochrome p450-like protein 0.0063 0.0113 0.0287
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0141 0.0318 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0032 0.0174
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0065 0.0065
Trypanosoma cruzi cytochrome P450, putative 0.0094 0.0194 0.0542
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0469 0.118 0.855
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0063 0.0113 0.239
Schistosoma mansoni alkaline phosphatase 0.0188 0.0442 0.2163
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0032
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0138 0.0378
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0233 0.056 0.5912
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0008 0.00000000030564
Schistosoma mansoni phosphoglycerate kinase 0.0197 0.0465 0.2275
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0142 0.032 0.032
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0545 0.1378 0.3995
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0138 0.0356
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0065 0.0417
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0235 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0063 0.0113 0.239
Trypanosoma cruzi cytochrome P450, putative 0.0094 0.0194 0.0542
Entamoeba histolytica hypothetical protein 0.0469 0.118 0.855
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0063 0.0113 0.239
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0257 0.0623 0.4486
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0063 0.0113 0.239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0749 0.1913 0.9356
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.0477 0.3418
Schistosoma mansoni alkaline phosphatase 0.0188 0.0442 0.2163
Entamoeba histolytica protein kinase rad3, putative 0.0201 0.0477 0.3418
Echinococcus granulosus cytochrome P450 2K1 0.0063 0.0113 0.0113
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0318 0.0904
Schistosoma mansoni phosphatidylinositol 4-kinase 0.008 0.0159 0.0779
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0057 0.0057
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0141 0.0318 0.1856
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.0882 0.5144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.0849 0.6136
Loa Loa (eye worm) hypothetical protein 0.0138 0.0311 0.1813
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0141 0.0318 0.3453
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0219 0.0522 0.1498
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.044
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0076 0.0493
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0047 0.0417
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0217 0.0517 0.3712
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0047 0.0113
Brugia malayi Phosphoglycerate kinase 0.0197 0.0465 0.3336
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.3393
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0063 0.0113 0.239
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0063 0.0113 0.239
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0065 0.032
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.008 0.0159 0.0159
Echinococcus granulosus chromobox protein 1 0.0081 0.016 0.016
Leishmania major DNA polymerase eta, putative 0.0074 0.0143 0.0369
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0047 0.0113
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.0143 0.1441
Schistosoma mansoni hypothetical protein 0.0142 0.032 0.1567
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0063 0.0113 0.239
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0065 0.0065
Brugia malayi Bromodomain containing protein 0.0087 0.0176 0.1224
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0141 0.0318 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0357 0.0885 0.6397
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0197 0.0465 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0065 0.0166
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0197 0.0465 0.3336
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0159 0.0929
Leishmania major hypothetical protein, conserved 0.141 0.3648 1
Plasmodium vivax hypothetical protein 0.008 0.0159 0.3393
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0052 0.0302
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0065 0.0612
Schistosoma mansoni phosphoglycerate kinase 0.0197 0.0465 0.2275
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0063 0.0113 0.239
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0065 0.137
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0379 0.0942 0.0942
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0065 0.0166
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.008 0.0159 0.0159
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0356 0.0882 0.9364
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0063 0.0113 0.239
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0063 0.0113 0.239
Echinococcus multilocularis serine protein kinase ATM 0.0219 0.0522 0.0522
Trypanosoma brucei polo-like protein kinase 0.0109 0.0235 0.2431
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.008 0.0159 0.0159
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0138 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0067 0.0427
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0065 0.032
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0063 0.0113 0.239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0226 0.0541 0.3886
Leishmania major cytochrome p450-like protein 0.0063 0.0113 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Chlamydia trachomatis phosphoglycerate kinase 0.0197 0.0465 1
Schistosoma mansoni microtubule-associated protein tau 0.0799 0.2045 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0141 0.0318 0.3453
Leishmania major phosphoglycerate kinase B, cytosolic 0.0197 0.0465 0.1256
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0065 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Echinococcus granulosus zinc finger protein 0.0023 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0219 0.0522 0.3749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0942 0.6813
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0235 0.0662
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0188 0.0442 0.0442
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0076 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0533 0.3834
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0217 0.0517 0.2527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.0159 0.1101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.002 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Plasmodium falciparum phosphatidylinositol 4-kinase 0.008 0.0159 0.3393
Giardia lamblia Kinase, PLK 0.0109 0.0235 0.2431
Echinococcus granulosus chromobox protein 1 0.0081 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0201 0.0477 0.2779
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0217 0.0517 0.3712
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0379 0.0942 1
Giardia lamblia GTOR 0.0379 0.0942 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0163 0.0951
Brugia malayi PHD-finger family protein 0.0029 0.0024 0.0113
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0063 0.0113 0.239
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.002 0.0393
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0141 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0047 0.0072 0.042
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0222 0.0532 0.583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.008 0.0159 0.1681
Schistosoma mansoni hypothetical protein 0.0063 0.0113 0.0551
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0368 0.0913 0.9695
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0159 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.0849 0.6136
Leishmania major phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.0414
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0072 0.0138 0.0378
Mycobacterium ulcerans hypothetical protein 0.0027 0.002 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0265 0.1877
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.008 0.0159 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0235 0.1656
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0065 0.0417
Loa Loa (eye worm) CYP4Cod1 0.0094 0.0194 0.1133
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0065 0.0166
Schistosoma mansoni zinc finger protein 0.0023 0.0008 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.0882 0.6379
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0235 0.1656
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.008 0.0159 0.1616
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0379 0.0942 0.4604
Echinococcus multilocularis Zinc finger, PHD finger 0.0141 0.0318 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.01 0.0666
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0032
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0197 0.0465 0.5092
Plasmodium vivax phosphoglycerate kinase, putative 0.0197 0.0465 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0403 0.1005 0.7275
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0188 0.0442 0.0442
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0047 0.0284
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0062 0.0597
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0235 0.0662
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0235 0.1656
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0379 0.0942 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0379 0.0942 0.5491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0223 0.0533 0.3834
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.008 0.0159 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6344
Brugia malayi Phosphoglycerate kinase 0.0072 0.0138 0.0946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0354 0.0877 0.6344
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0217 0.0517 0.1483
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0008 0.0008
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0141 0.0318 0.2262
Schistosoma mansoni hypothetical protein 0.0039 0.0052 0.0253
Loa Loa (eye worm) phosphatidylinositol 3 0.0673 0.1715 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0072 0.0138 0.0378
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.002 0.0393
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0065 0.0612
Trypanosoma brucei phosphoglycerate kinase, putative 0.0072 0.0138 0.1389
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0141 0.0318 0.1556
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0403 0.1005 0.2907
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0141 0.0318 0.2262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.0849 0.6136
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0201 0.0477 0.0477
Echinococcus multilocularis chromobox protein 1 0.0081 0.016 0.016
Schistosoma mansoni fkbp-rapamycin associated protein 0.0201 0.0477 0.233
Leishmania major phosphatidylinositol kinase related protein, putative 0.0098 0.0205 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0237 0.0569 0.4094
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0197 0.0465 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0063 0.0113 0.239
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0063 0.0113 0.239
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0156 0.0358 0.3745
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0221
Brugia malayi Bromodomain containing protein 0.0044 0.0065 0.041
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0058 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.051 0.3661
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0076 0.0373
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0063 0.0113 0.239
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0065 0.0417
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0063 0.0113 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0532 0.3819
Echinococcus multilocularis dna polymerase eta 0.0074 0.0143 0.0143
Giardia lamblia Phosphatidylinositol 4-kinase 0.008 0.0159 0.1616
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.1616
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0029 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.008 0.0159 0.1681
Trypanosoma cruzi hypothetical protein, conserved 0.133 0.3437 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0063 0.0113 0.0287
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0063 0.0113 0.239
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.0173
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.032 0.2278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0942 0.6813
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0049
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.008 0.0159 0.1681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0188 0.0442 0.0442
Leishmania major phosphatidylinositol 3-kinase, putative 0.0343 0.0849 0.2309
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0197 0.0465 0.5092
Echinococcus granulosus alkaline phosphatase 0.0188 0.0442 0.0442
Brugia malayi Cytochrome P450 family protein 0.0198 0.0468 0.3354
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0063 0.0113 0.239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0343 0.0849 0.6136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0138 0.0311 0.0882
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0159 0.0929
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0379 0.0942 0.2722
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0159 0.0929
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0065 0.0157
Trypanosoma cruzi target of rapamycin kinase 3 0.0368 0.0913 0.2639
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0159 0.1101
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0141 0.0318 0.0851
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.008 0.0159 0.3393
Trypanosoma brucei phosphoglycerate kinase 0.0197 0.0465 0.4897
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0465 0.1167 0.8459
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0008 0.0008
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0063 0.0113 0.239
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0333 0.0821 0.0821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.0596 0.4288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0265 0.1877
Entamoeba histolytica hypothetical protein 0.008 0.0159 0.1101
Leishmania major cytochrome p450-like protein 0.0094 0.0194 0.0511
Leishmania major phosphoglycerate kinase C, glycosomal 0.0197 0.0465 0.1256
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0017 0.0017
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0403 0.1005 0.1005
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0356 0.0882 0.2401
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0393
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0197 0.0465 0.1333
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.0477 0.1365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0913 0.6604
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0368 0.0913 0.6604
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.008 0.0159 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0065 0.0612
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0365 0.0906 0.6552
Toxoplasma gondii cytochrome p450 superfamily protein 0.0063 0.0113 0.1163
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0235 0.1372
Leishmania major DNA polymerase kappa, putative 0.0045 0.0065 0.0157
Loa Loa (eye worm) hypothetical protein 0.0039 0.005 0.0291
Echinococcus granulosus phosphoglycerate kinase 1 0.0197 0.0465 0.0465
Loa Loa (eye worm) cytochrome P450 family protein 0.0198 0.0468 0.2728

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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