Detailed information for compound 1065123

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.087 | Formula: C9H7BrFN5O2
  • H donors: 3 H acceptors: 3 LogP: 1.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1nonc1N)\Nc1ccc(c(c1)Br)F
  • InChi: 1S/C9H7BrFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)
  • InChiKey: ORHZJUSHZUCMKR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens indoleamine 2,3-dioxygenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00463 indoleamine 2,3-dioxygenase, putative Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130288 All targets in OG5_130288
Schistosoma japonicum IPR000898,Indoleamine 2,3-dioxygenase,domain-containing Get druggable targets OG5_130288 All targets in OG5_130288
Brugia malayi indoleamine 2,3-dioxygenase Get druggable targets OG5_130288 All targets in OG5_130288
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 Get druggable targets OG5_130288 All targets in OG5_130288
Echinococcus granulosus indoleamine 23 dioxygenase 2 Get druggable targets OG5_130288 All targets in OG5_130288
Candida albicans similar to indoleamine 2,3-dioxygenases Get druggable targets OG5_130288 All targets in OG5_130288
Loa Loa (eye worm) indoleamine 2,3-dioxygenase Get druggable targets OG5_130288 All targets in OG5_130288
Candida albicans similar to indoleamine 2,3-dioxygenases Get druggable targets OG5_130288 All targets in OG5_130288
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0034 0.0212 0.0212
Schistosoma mansoni ap endonuclease 0.002 0.0107 0.0107
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0094 0.0663 0.1522
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0115 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Echinococcus multilocularis dna polymerase eta 0.0124 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0059 0.0119
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.02 0.02
Schistosoma mansoni 6-phosphofructokinase 0.0094 0.0663 0.0663
Brugia malayi Bloom's syndrome protein homolog 0.0017 0.0085 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.02 0.0457
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0157
Schistosoma mansoni hypothetical protein 0.0014 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0089 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0044
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0127 0.086
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0237 0.358
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0082 0.1231
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0237 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0006 0.0001 0.0006
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0006 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0518 0.1188
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0127 0.0292
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0065 0.0131
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0434 0.1509
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0434 0.0434
Brugia malayi MBOAT family protein 0.0034 0.0212 0.0427
Trypanosoma brucei DNA polymerase eta, putative 0.0124 0.0889 0.2042
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0518 0.1897
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0082 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0518 0.119
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0034 0.0212 0.0212
Plasmodium falciparum serine repeat antigen 3 0.0006 0.0001 0.0007
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0094 0.0663 0.2569
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0034 0.0212 0.0212
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0663 0.3699
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.02 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Echinococcus multilocularis Protein lozenge 0.0048 0.0318 0.0318
Echinococcus granulosus survival motor neuron protein 1 0.0205 0.1495 0.1495
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0885 0.2031
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0059 0.0059
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0014 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0309 0.2271 1
Echinococcus granulosus dna polymerase eta 0.0124 0.0889 0.0889
Toxoplasma gondii cathepsin CPC1 0.0006 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Trypanosoma brucei glycerol uptake protein, putative 0.0034 0.0212 0.0486
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni DNA polymerase eta 0.0124 0.0889 0.0889
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0065
Entamoeba histolytica vacuolar protein sorting 26 0.0034 0.0212 0.3189
Leishmania major mitochondrial DNA polymerase beta 0.0586 0.4352 1
Leishmania major cathepsin L-like protease 0.0032 0.02 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0006 0.0001 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0147 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0014 0.0028
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Schistosoma mansoni coup transcription factor 0.0031 0.0186 0.0186
Entamoeba histolytica cysteine protease, putative 0.0032 0.02 0.3012
Leishmania major importin beta-1 subunit, putative 0.0025 0.0144 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Toxoplasma gondii hypothetical protein 0.0008 0.0014 0.0094
Brugia malayi Smad1 0.0007 0.0009 0.0018
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.0518 0.0518
Echinococcus multilocularis geminin 0.0178 0.129 0.129
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.0905 0.0905
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0127 0.2435
Schistosoma mansoni terminal deoxycytidyl transferase 0.0075 0.0518 0.0518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0119 0.0665
Plasmodium falciparum serine repeat antigen 6 0.0006 0.0001 0.0007
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus multilocularis dna polymerase kappa 0.0075 0.0518 0.0518
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0586 0.4352 1
Toxoplasma gondii phosphofructokinase PFKII 0.0025 0.0147 0.0997
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0022 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0065
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.013 0.03
Plasmodium falciparum serine repeat antigen 5 0.0006 0.0001 0.0007
Brugia malayi tailless protein 0.0014 0.0065 0.0131
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Schistosoma mansoni cpg binding protein 0.0025 0.0143 0.0143
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0014 0.0014
Schistosoma mansoni smad 0.0007 0.0009 0.0009
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0147 0.0997
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0157
Brugia malayi indoleamine 2,3-dioxygenase 0.0667 0.4956 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0186 0.0186
Brugia malayi cathepsin Z-like cysteine proteinase 0.0006 0.0001 0.0002
Treponema pallidum alginate O-acetylation protein (algI) 0.0034 0.0212 0.2958
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0115 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0186 0.0376
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0065 0.0131
Entamoeba histolytica hypothetical protein 0.0038 0.0237 0.358
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0191 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0082 0.1231
Echinococcus granulosus smad 0.0007 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0186 0.0376
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0025 0.0147 0.5
Onchocerca volvulus 0.0034 0.0212 0.0742
Loa Loa (eye worm) hypothetical protein 0.0022 0.0119 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0006 0.0001 0.0006
Plasmodium falciparum serine repeat antigen 8 0.0006 0.0001 0.0007
Brugia malayi hypothetical protein 0.0014 0.0065 0.0131
Plasmodium falciparum serine repeat antigen 2 0.0006 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0107 0.0217
Leishmania major cathepsin L-like protease 0.0032 0.02 0.0459
Leishmania major cathepsin L-like protease 0.0124 0.0885 0.2033
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0186 0.0376
Loa Loa (eye worm) 6-phosphofructokinase 0.0094 0.0663 0.1339
Loa Loa (eye worm) hhat protein 0.0034 0.0212 0.0427
Mycobacterium ulcerans hypothetical protein 0.0309 0.2271 1
Schistosoma mansoni cathepsin C 0.0006 0.0001 0.0001
Brugia malayi hypothetical protein 0.0021 0.0115 0.0232
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0082 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.2036 0.4678
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0075 0.0518 0.1045
Plasmodium vivax vivapain-2 0.0032 0.02 0.1354
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Loa Loa (eye worm) hypothetical protein 0.0157 0.1131 0.2282
Schistosoma mansoni cpg binding protein 0.0026 0.0154 0.0154
Brugia malayi MBOAT family protein 0.0034 0.0212 0.0427
Leishmania major ATP-dependent phosphofructokinase 0.0094 0.0663 0.1524
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0157 0.1131 0.3982
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.02 0.0403
Onchocerca volvulus 0.0032 0.02 0.07
Brugia malayi 6-phosphofructokinase 0.0094 0.0663 0.1339
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0232
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0186 0.0186
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0085 0.0576
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0186 0.0186
Brugia malayi Protein kinase domain containing protein 0.0222 0.162 0.3269
Entamoeba histolytica recQ family helicase, putative 0.0017 0.0085 0.1282
Schistosoma mansoni cpg binding protein 0.0026 0.0154 0.0154
Onchocerca volvulus 0.0014 0.0065 0.0224
Echinococcus granulosus cathepsin b 0.0006 0.0001 0.0001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0186 0.0186
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0028
Brugia malayi cathepsin L-like precursor 0.0022 0.0119 0.0241
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0667 0.4956 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0186 0.0186
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0239 0.0239
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0667 0.4956 0.4956
Schistosoma mansoni smad1 5 8 and 0.0007 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.003 0.0178 0.0178
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.0224
Schistosoma mansoni hypothetical protein 0.0089 0.0623 0.0623
Brugia malayi nuclear hormone receptor 0.0031 0.0186 0.0376
Echinococcus granulosus importin subunit beta 1 0.0031 0.0188 0.0188
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0885 0.2031
Loa Loa (eye worm) hypothetical protein 0.0032 0.02 0.0403
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0518 0.1188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.028 0.0566
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Onchocerca volvulus 0.0032 0.02 0.07
Schistosoma mansoni lozenge 0.0048 0.0318 0.0318
Echinococcus multilocularis apoptotic protease activating factor 1 0.0027 0.0157 0.0157
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0237 0.1324
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0065 0.0065
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0075 0.0518 0.1897
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0107 0.0728
Schistosoma mansoni blooms syndrome DNA helicase 0.0008 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0085 0.0172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0157
Plasmodium falciparum importin beta, putative 0.0031 0.0188 0.1275
Loa Loa (eye worm) hypothetical protein 0.0022 0.0119 0.0241
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0034 0.0212 0.3189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0119 0.0665
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0239 0.1749 0.1749
Brugia malayi Papain family cysteine protease containing protein 0.0006 0.0001 0.0002
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0065
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0203 0.1476 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0065 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0059 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni smad1 5 8 and 0.0007 0.0009 0.0009
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0127 0.0256
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0518 0.119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0107 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0082 0.0185
Toxoplasma gondii 6-phosphofructokinase 0.0025 0.0147 0.0997
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0186 0.0186
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0009 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.0885 0.2031
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0008 0.0014 0.0014
Onchocerca volvulus 0.0245 0.1793 0.6317
Brugia malayi cathepsin L-like cysteine proteinase 0.0006 0.0001 0.0002
Trypanosoma cruzi glycerol uptake protein, putative 0.0034 0.0212 0.0484
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0085 0.0172
Echinococcus multilocularis sterol O acyltransferase 1 0.0034 0.0212 0.0212
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.028 0.0566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0805
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0059 0.0059
Echinococcus multilocularis cpg binding protein 0.0026 0.0154 0.0154
Trypanosoma brucei chrX additional, unordered contigs 0.0023 0.013 0.03
Loa Loa (eye worm) cathepsin B 0.0006 0.0001 0.0002
Onchocerca volvulus 0.0384 0.2838 1
Plasmodium vivax unspecified product 0.0017 0.0082 0.0553
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Trypanosoma cruzi cysteine peptidase, putative 0.0011 0.0037 0.0082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Leishmania major cathepsin L-like protease 0.0032 0.02 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0107 0.162
Leishmania major hypothetical protein, conserved 0.0034 0.0212 0.0486
Echinococcus multilocularis cysteine protease 0.0032 0.02 0.02
Brugia malayi nuclear receptor NHR-88 0.0014 0.0065 0.0131
Schistosoma mansoni DNA polymerase IV / kappa 0.0023 0.013 0.013
Echinococcus multilocularis 6 phosphofructokinase 0.0094 0.0663 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0006 0.0001 0.0006
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Loa Loa (eye worm) apoptosis regulator protein 0.0089 0.0623 0.1256
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0006 0.0001 0.0007
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0203 0.1476 0.2978
Echinococcus granulosus o acyltransferase membrane bound domain 0.0034 0.0212 0.0212
Brugia malayi hypothetical protein 0.0014 0.0065 0.0131
Plasmodium vivax 6-phosphofructokinase, putative 0.0025 0.0147 0.0997
Brugia malayi hypothetical protein 0.0384 0.2838 0.5727
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0186 0.0186
Loa Loa (eye worm) DR-78 0.0014 0.0065 0.0131
Schistosoma mansoni zinc finger protein 0.0034 0.0212 0.0212
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0178 0.0359
Brugia malayi DIX domain containing protein 0.0008 0.0014 0.0028
Echinococcus multilocularis snurportin 1 0.033 0.2433 0.2433
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0094 0.0663 0.5
Entamoeba histolytica hypothetical protein 0.0006 0.0001 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Leishmania major basic transcription factor 3a, putative 0.0038 0.0237 0.0546
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0434 0.294
Echinococcus multilocularis transcription factor btf3 0.0038 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0384 0.2838 0.5727
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0186 0.0186
Plasmodium vivax vivapain-3 0.0017 0.0082 0.0553
Loa Loa (eye worm) MBOAT family protein 0.0034 0.0212 0.0427
Onchocerca volvulus 0.0025 0.0143 0.05
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0186 0.0186
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0082 0.0082
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0065
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0203 0.1476 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus multilocularis microtubule associated protein 2 0.1339 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0107 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0186 0.0376
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0179 0.0179
Leishmania major glycerol uptake protein, putative 0.0034 0.0212 0.0486
Plasmodium falciparum serine repeat antigen 1 0.0006 0.0001 0.0007
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0034 0.0212 0.3189
Brugia malayi ImpB/MucB/SamB family protein 0.0124 0.0889 0.1793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0186 0.0376
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Onchocerca volvulus 0.0021 0.0115 0.0401
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Plasmodium vivax unspecified product 0.0006 0.0001 0.0007
Entamoeba histolytica recQ family helicase, putative 0.0008 0.0019 0.0292
Brugia malayi Doublecortin family protein 0.0021 0.0115 0.0232
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0078 0.0157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0006 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.0017 0.0085 0.0474
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Loa Loa (eye worm) hypothetical protein 0.0236 0.1722 0.3475
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.013 0.0297
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0006 0.0001 0.0002
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0203 0.1476 0.1476
Onchocerca volvulus 0.0032 0.02 0.07
Onchocerca volvulus 0.0027 0.0157 0.055
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0107 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0237 0.1324
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0157 0.055
Echinococcus granulosus cathepsin b 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0089 0.0623 0.1256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.0733 0.1479
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0663 0.3699
Leishmania major glycerol uptake protein, putative 0.0034 0.0212 0.0486
Leishmania major glycerol uptake protein, putative 0.0034 0.0212 0.0486
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni hypothetical protein 0.0014 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.0032 0.02 0.0459
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0006 0.0001 0.0007
Echinococcus granulosus cathepsin l1 0.0022 0.0119 0.0119
Echinococcus multilocularis segment polarity protein dishevelled 0.0008 0.0014 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0186 0.0186
Plasmodium falciparum serine repeat antigen 7 0.0006 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni ran 0.0023 0.0127 0.0127
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0237 0.0546
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0025 0.0147 0.0997
Echinococcus granulosus Smad4 0.0007 0.0009 0.0009
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0034 0.0212 0.0212
Schistosoma mansoni dishevelled 0.0008 0.0014 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0009 0.0018
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0115 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.031 0.031
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0082 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0006 0.0001 0.0006
Plasmodium falciparum DNA repair protein REV1, putative 0.0023 0.013 0.0884
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.013 0.03
Echinococcus granulosus cathepsin L 0.0006 0.0001 0.0001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0127 0.0289
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0144 0.0805
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0059 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0127 0.0289
Loa Loa (eye worm) RecQ helicase 0.0017 0.0085 0.0172
Trichomonas vaginalis DNA helicase recq, putative 0.0017 0.0085 0.0474
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1793 1
Entamoeba histolytica recQ family DNA helicase 0.0009 0.0022 0.0329
Echinococcus multilocularis cysteine protease 0.0032 0.02 0.02
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0025 0.0147 0.0997
Schistosoma mansoni hypothetical protein 0.0667 0.4956 0.4956
Schistosoma mansoni hypothetical protein 0.0014 0.0059 0.0059
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0237 0.1609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0022 0.0148
Trichomonas vaginalis transmembrane protein nessy, putative 0.0034 0.0212 0.118
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.013 0.03
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0065 0.0131
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0034 0.0212 0.0212
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0006 0.0001 0.0016
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0237 0.0543
Brugia malayi hypothetical protein 0.0027 0.0157 0.0317
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0006 0.0001 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0344 0.0789
Brugia malayi cathepsin L precursor 0.0006 0.0001 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0186 0.0186
Onchocerca volvulus 0.0008 0.0014 0.0045
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0082 0.0553
Schistosoma mansoni hypothetical protein 0.0089 0.0623 0.0623
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0239 0.0239
Trypanosoma brucei DNA damage repair protein, putative 0.0023 0.013 0.03
Trichomonas vaginalis DNA polymerase eta, putative 0.0075 0.0518 0.2888
Loa Loa (eye worm) cysteine protease 0.0032 0.02 0.0403
Brugia malayi nuclear receptor RXR 0.0014 0.0065 0.0131
Entamoeba histolytica hypothetical protein 0.0038 0.0239 0.3607
Loa Loa (eye worm) fibroinase 0.0032 0.02 0.0403
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0006 0.0001 0.0007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0022 0.0048
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Echinococcus granulosus sterol O acyltransferase 1 0.0034 0.0212 0.0212
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0022 0.0148
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0034 0.0212 0.0212
Echinococcus granulosus 6 phosphofructokinase 0.0094 0.0663 0.0663
Echinococcus multilocularis cathepsin b 0.0006 0.0001 0.0001
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0006 0.0001 0.0007
Echinococcus granulosus RUN 0.0021 0.0115 0.0115
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0277 0.2036 0.468
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.0317
Brugia malayi cathepsin Z-like cysteine proteinase 0.0006 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0203 0.1476 0.1476
Schistosoma mansoni smad1 5 8 and 0.0007 0.0009 0.0009
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.013 0.0884
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0107 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0186 0.0186
Brugia malayi nuclear hormone receptor 0.0014 0.0065 0.0131
Schistosoma mansoni microtubule-associated protein tau 0.1339 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0178 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Schistosoma mansoni zinc finger protein 0.0014 0.0065 0.0065
Echinococcus multilocularis cathepsin L 0.0017 0.0082 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0186 0.0186
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0434 0.0997
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1571 0.3169
Entamoeba histolytica phosphofructokinase, putative 0.0094 0.0663 1
Loa Loa (eye worm) ctsf protein 0.0032 0.02 0.0403
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.0574 0.1317
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.02 0.1354
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0089 0.0623 0.0623
Echinococcus granulosus cysteine protease 0.0017 0.0082 0.0082
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0127 0.0256
Entamoeba histolytica hypothetical protein 0.0038 0.0239 0.3607
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0034 0.0212 0.0212
Brugia malayi hypothetical protein 0.0205 0.1495 0.3016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.027 0.0545
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0074
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0157 0.0157
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0434 0.0434
Trypanosoma cruzi GUP1, putative 0.0034 0.0212 0.0484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Brugia malayi MH2 domain containing protein 0.0007 0.0009 0.0018
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0119 0.0119
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0075 0.0518 0.2888
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0186 0.0376
Brugia malayi cathepsin B-like cysteine proteinase 0.0006 0.0001 0.0002
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0082 0.0185
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.0733 0.1479
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0006 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Loa Loa (eye worm) hypothetical protein 0.0384 0.2838 0.5727
Schistosoma mansoni hypothetical protein 0.0667 0.4956 0.4956
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0518 0.1045
Loa Loa (eye worm) MBOAT family protein 0.0034 0.0212 0.0427
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0065 0.0065
Schistosoma mansoni lipoxygenase 0.0127 0.0905 0.0905
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0017 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0043 0.028 0.0566
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0065 0.0131
Schistosoma mansoni hypothetical protein 0.0034 0.0212 0.0212
Echinococcus multilocularis survival motor neuron protein 1 0.0205 0.1495 0.1495
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0663 0.3699
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0006 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0434 0.0434
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0143 0.0289
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0075 0.0518 0.119
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0237 0.1324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni cathepsin B (C01 family) 0.0006 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.0031 0.0186 0.0376
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0065
Onchocerca volvulus Cathepsin L homolog 0.0032 0.02 0.07
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0186 0.0186
Echinococcus granulosus o acyltransferase membrane bound domain 0.0034 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0186 0.0376
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.0361 0.0361
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0186 0.0186
Brugia malayi hypothetical protein 0.0021 0.0115 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0186 0.0376
Onchocerca volvulus 0.0032 0.02 0.07
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0034 0.0212 0.3189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0186 0.0376
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0186 0.0186
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0034 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Echinococcus multilocularis cathepsin L 0.0006 0.0001 0.0001
Echinococcus multilocularis cathepsin b 0.0006 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0006 0.0001 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0082 0.1231
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0119 0.0241
Brugia malayi Hhat protein 0.0034 0.0212 0.0427
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0025 0.0147 0.5
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0065 0.0065
Schistosoma mansoni dep domain containing protein 0.0008 0.0014 0.0014
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0009 0.0009
Brugia malayi Papain family cysteine protease containing protein 0.0006 0.0001 0.0002
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0034 0.0212 0.0212
Leishmania major DNA polymerase kappa, putative 0.0023 0.013 0.03
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.02 0.02
Brugia malayi ecdysteroid receptor 0.0031 0.0186 0.0376
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0203 0.1476 1
Onchocerca volvulus 0.0014 0.0065 0.0224
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Schistosoma mansoni importin beta-1 0.0031 0.0188 0.0188
Trypanosoma cruzi cruzipain precursor, putative 0.0124 0.0885 0.2031
Brugia malayi MBOAT family protein 0.0034 0.0212 0.0427
Trypanosoma cruzi glycerol uptake protein, putative 0.0034 0.0212 0.0484
Brugia malayi hypothetical protein 0.0038 0.0239 0.0483
Trypanosoma brucei glycerol uptake protein, putative 0.0034 0.0212 0.0486
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0008 0.0019 0.0131
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0089 0.0623 0.1256
Plasmodium vivax unspecified product 0.0011 0.0037 0.0248
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0094 0.0663 1
Echinococcus granulosus protein tyrosine kinase 0.0219 0.1601 0.1601
Loa Loa (eye worm) hypothetical protein 0.0022 0.0119 0.0241
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0239 0.0239
Brugia malayi 6-phosphofructokinase 0.0094 0.0663 0.1339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0085 0.0195
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0082 0.1231
Trypanosoma cruzi glycerol uptake protein, putative 0.0034 0.0212 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0186 0.0376
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0065 0.0065
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0186 0.0653
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0089 0.0623 0.0623
Echinococcus multilocularis protein tyrosine kinase 0.0219 0.1601 0.1601
Schistosoma mansoni hypothetical protein 0.0178 0.129 0.129
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0107 0.0728
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Onchocerca volvulus 0.0021 0.0115 0.0401
Leishmania major glycerol uptake protein, putative 0.0034 0.0212 0.0486
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0188 0.0432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0518 0.1188
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0127 0.0127
Brugia malayi hypothetical protein 0.0008 0.0014 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0239 0.1749 0.1749
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0085 0.0195
Plasmodium vivax serine-repeat antigen (SERA) 0.0006 0.0001 0.0007
Entamoeba histolytica phosphofructokinase, putative 0.0094 0.0663 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.0319 0.2159
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Schistosoma mansoni Smad4 0.0007 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0191 0.0191
Brugia malayi hypothetical protein 0.0008 0.0014 0.0028
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus granulosus bloom syndrome protein 0.0017 0.0085 0.0085
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0089 0.0623 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0186 0.0376
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.0131
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Brugia malayi nuclear receptor NHR-67 0.0014 0.0065 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0082 0.0188
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Schistosoma mansoni cathepsin S (C01 family) 0.0006 0.0001 0.0001
Mycobacterium ulcerans 6-phosphofructokinase 0.0094 0.0663 0.2569
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0008 0.0014 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0191 0.0191
Brugia malayi Cathepsin L-like precursor 0.0011 0.0037 0.0074
Trichomonas vaginalis DNA helicase recq1, putative 0.0017 0.0085 0.0474
Onchocerca volvulus 0.0031 0.0186 0.0653
Onchocerca volvulus 0.0031 0.0191 0.067
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0065 0.0065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0085 0.0576
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0017 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Brugia malayi MBOAT family protein 0.0034 0.0212 0.0427
Schistosoma mansoni polycystin 1-related 0.0021 0.0115 0.0115
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Onchocerca volvulus Cathepsin L homolog 0.0032 0.02 0.07
Brugia malayi fibroinase precursor 0.0006 0.0001 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.028 0.0566
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0186 0.0186
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0237 0.1609
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0344 0.0789
Onchocerca volvulus 0.0022 0.0119 0.0416
Echinococcus multilocularis RUN 0.0021 0.0115 0.0115
Leishmania major cysteine peptidase A (CPA) 0.0032 0.02 0.0459
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.013 0.03
Leishmania major cathepsin L-like protease 0.0032 0.02 0.0459
Trypanosoma cruzi DNA polymerase eta, putative 0.0073 0.0501 0.115
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0094 0.0663 0.1524
Schistosoma mansoni sterol O-acyltransferase 1 0.0034 0.0212 0.0212
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0191 0.0191
Toxoplasma gondii preprocathepsin c precursor, putative 0.0006 0.0001 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0236 0.1722 0.3475
Brugia malayi Importin beta-1 subunit 0.0031 0.0188 0.038
Brugia malayi hypothetical protein 0.0016 0.0078 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.0131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0518 0.1188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0119
Loa Loa (eye worm) hypothetical protein 0.0009 0.0022 0.0044
Brugia malayi Pre-SET motif family protein 0.0215 0.1571 0.3169
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.02 0.1354
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0022 0.0044
Leishmania major GTP-binding protein, putative 0.0023 0.0127 0.0292
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0034 0.0212 0.0212
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0107 0.1335
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0434 0.1509
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.02 0.02
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0034 0.0212 0.0212
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0017 0.0085 0.0193
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.02 0.3012
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.02 0.3012
Brugia malayi Cathepsin L-like precursor 0.0022 0.0119 0.0241
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0009 0.0009
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0025 0.0147 0.2827
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.031 0.031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0107 0.0217
Loa Loa (eye worm) phosphofructokinase 0.0094 0.0663 0.1339
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0006 0.0001 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.031 0.031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0186 0.0376
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0115 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Giardia lamblia DINP protein human, muc B family 0.0075 0.0518 1
Trichomonas vaginalis porcupine, putative 0.0034 0.0212 0.118
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Echinococcus granulosus snurportin 1 0.033 0.2433 0.2433
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0006
Plasmodium vivax serine-repeat antigen (SERA) 0.0006 0.0001 0.0007
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0115 0.0778
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0006 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0006 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0082 0.0455
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0075 0.0518 0.0518
Schistosoma mansoni cathepsin s 0.0011 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0212 0.0427
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Schistosoma mansoni ran 0.0023 0.0127 0.0127
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0006 0.0001 0.0002
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0119 0.1798
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0037 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0001 0.0006
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0034 0.0212 0.0427
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.02 0.0403
Schistosoma mansoni hypothetical protein 0.0038 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.02 0.1114
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0078 0.0157
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0186 0.0186
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.013 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0186 0.0376
Brugia malayi MH1 domain containing protein 0.0007 0.0009 0.0018
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0008 0.0014 0.0028
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0186 0.0186
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.02 0.02
Schistosoma mansoni lipoxygenase 0.0088 0.062 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0065 0.0131
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0586 0.4352 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0115 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Echinococcus multilocularis regulator of G protein signaling 7 0.0008 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Leishmania major cathepsin L-like protease 0.0124 0.0885 0.2033
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0017 0.0085 0.0576
Schistosoma mansoni survival motor neuron protein 0.0042 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0212 0.118
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0082 0.0188
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0006 0.0001 0.0001
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0006 0.0001 0.0007
Toxoplasma gondii hypothetical protein 0.0034 0.0212 0.1433
Loa Loa (eye worm) hypothetical protein 0.0016 0.0078 0.0157
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0186 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0082 0.1231
Brugia malayi MH1 domain containing protein 0.0007 0.0009 0.0018
Toxoplasma gondii cathepsin CPC2 0.0006 0.0001 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0188 0.0432
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0203 0.1476 0.1476
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.02 0.02
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0191 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0518 0.1897
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0127 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0006 0.0001 0.0002
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0034 0.0212 0.0212
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0037 0.0074
Trypanosoma brucei unspecified product 0.0075 0.0518 0.119
Schistosoma mansoni hypothetical protein 0.0178 0.129 0.129
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0124 0.0889 0.204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0186 0.0376
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0006 0.0001 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Echinococcus granulosus dna polymerase kappa 0.0075 0.0518 0.0518
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.013 0.0884
Plasmodium vivax SET domain protein, putative 0.0031 0.0191 0.1295
Brugia malayi nuclear receptor RXR 0.0016 0.0078 0.0157
Loa Loa (eye worm) hypothetical protein 0.0008 0.0014 0.0028
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0212 0.3189
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0034 0.0212 0.0212
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0006 0.0001 0.0007
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.2036 0.468
Schistosoma mansoni hypothetical protein 0.0014 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0034 0.0212 0.0212
Echinococcus granulosus cpg binding protein 0.0026 0.0154 0.0154
Echinococcus granulosus GPCR family 2 0.0014 0.0059 0.0059
Entamoeba histolytica deoxycytidyl transferase, putative 0.0075 0.0518 0.7807
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0085 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Echinococcus multilocularis smad 0.0007 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0082 0.0082
Echinococcus granulosus apoptotic protease activating factor 1 0.0027 0.0157 0.0157
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0085 0.0576
Brugia malayi Cathepsin L-like precursor 0.0022 0.0119 0.0241
Brugia malayi hypothetical protein 0.0016 0.0078 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0008 0.0014 0.0045
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.0905 0.0905
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0186 0.0376
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0025 0.0147 0.0821
Brugia malayi RNA, U transporter 1 0.0088 0.0616 0.1243
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Entamoeba histolytica phosphofructokinase, putative 0.0094 0.0663 1
Loa Loa (eye worm) MBOAT family protein 0.0034 0.0212 0.0427
Echinococcus granulosus segment polarity protein dishevelled 0.0008 0.0014 0.0014
Echinococcus granulosus caspase 2 0.0027 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.0002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0107 0.2058
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.0574 0.1317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0169 0.1221 0.2463
Schistosoma mansoni DNA helicase recq1 0.0017 0.0085 0.0085
Echinococcus granulosus geminin 0.0178 0.129 0.129
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.0344 0.0789
Trichomonas vaginalis phosphofructokinase, putative 0.0094 0.0663 0.3699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0107 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0078 0.0157
Plasmodium falciparum serine repeat antigen 9 0.0006 0.0001 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0518 0.119
Trypanosoma cruzi GUP1, putative 0.0034 0.0212 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0107 0.0599
Schistosoma mansoni ap endonuclease 0.002 0.0107 0.0107
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0078 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.013 0.0297
Entamoeba histolytica hypothetical protein 0.0038 0.0239 0.3607
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.013 0.03
Brugia malayi MH2 domain containing protein 0.0104 0.0733 0.1479
Brugia malayi MH2 domain containing protein 0.0007 0.0009 0.0018
Plasmodium vivax DNA repair protein REV1, putative 0.0023 0.013 0.0884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0186 0.0376
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0065
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0667 0.4956 0.4956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Giardia lamblia Sgs1 DNA helicase, putative 0.0017 0.0085 0.1625
Leishmania major DNA damage repair protein, putative 0.0023 0.013 0.03
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0006 0.0001 0.0007
Onchocerca volvulus 0.0032 0.02 0.07
Toxoplasma gondii exonuclease III APE 0.002 0.0107 0.0728
Schistosoma mansoni DNA helicase recq5 0.0017 0.0085 0.0085
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0006 0.0001 0.0007
Loa Loa (eye worm) Smad1 0.0007 0.0009 0.0018
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0082 0.0185
Trypanosoma brucei unspecified product 0.0052 0.0344 0.0789
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.031 0.0626
Leishmania major cathepsin L-like protease 0.0124 0.0885 0.2033
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0008 0.0019 0.0131
Loa Loa (eye worm) hhat protein 0.0034 0.0212 0.0427
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0074
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0188 0.1275
Brugia malayi Pre-SET motif family protein 0.0031 0.0191 0.0386
Plasmodium vivax importin-beta 2, putative 0.0031 0.0188 0.1275
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0186 0.0186
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.02 0.1354
Toxoplasma gondii hypothetical protein 0.0095 0.0665 0.4506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.031 0.031
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0006 0.0001 0.0006
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0586 0.4352 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0009 0.0022 0.0048
Onchocerca volvulus Cathepsin F homolog 0.0032 0.02 0.07
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0124 0.0889 0.1793
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0115 0.0115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0027 0.0157 0.0157
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0518 0.1897
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0065 0.0065
Brugia malayi N-terminal motif family protein 0.0157 0.1131 0.2282
Brugia malayi regulator of G-protein signaling egl-10 0.0008 0.0014 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0107 0.0245
Brugia malayi MBOAT family protein 0.0034 0.0212 0.0427
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0704 0.5232 0.5232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.031 0.031
Loa Loa (eye worm) TK/FAK protein kinase 0.0222 0.162 0.3269
Entamoeba histolytica hypothetical protein 0.0038 0.0239 0.3607
Loa Loa (eye worm) hypothetical protein 0.0034 0.0212 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0212 0.118
Schistosoma mansoni tyrosine kinase 0.0219 0.1601 0.1601
Leishmania major glycerol uptake protein, putative 0.0034 0.0212 0.0486
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0203 0.1476 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0107 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0186 0.0653
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.0804 0.1846
Echinococcus granulosus transcription factor btf3 0.0038 0.0237 0.0237
Plasmodium vivax vivapain-2 0.0032 0.02 0.1354
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0065 0.0131
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.02 0.02
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0186 0.0186
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0144 0.0329
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0127 0.086
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0186 0.0186
Echinococcus granulosus Pleckstrin G protein interacting region 0.0008 0.0014 0.0014
Giardia lamblia DNA damage repair protein 0.0023 0.013 0.2504
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0006 0.0001 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0186 0.0186
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0686 0.1574
Entamoeba histolytica Ran family GTPase 0.0023 0.0127 0.1913
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0082 0.0574 0.1319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0212 0.0427
Plasmodium falciparum serine repeat antigen 4 0.0006 0.0001 0.0007
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0006 0.0001 0.0007
Brugia malayi CXXC zinc finger family protein 0.0025 0.0143 0.0289
Echinococcus multilocularis GPCR, family 2 0.0014 0.0059 0.0059
Echinococcus granulosus regulator of G protein signaling 7 0.0008 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0205 0.1495 0.3016
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.0885 0.2033
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0017 0.0085 0.0085
Echinococcus granulosus cathepsin l1 0.0032 0.02 0.02
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0186 0.0376
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0034 0.0212 0.0212
Loa Loa (eye worm) DIX domain-containing protein 0.0008 0.0014 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0082 0.1231
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0017 0.0085 0.0172
Brugia malayi Cathepsin L-like precursor 0.0032 0.02 0.0403
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0082 0.0165
Loa Loa (eye worm) runx1 0.0048 0.0318 0.0641
Trypanosoma cruzi cruzipain precursor, putative 0.0011 0.0037 0.0082
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0009 0.0018
Schistosoma mansoni 6-phosphofructokinase 0.0094 0.0663 0.0663
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0212 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0006 0.0001 0.0006
Schistosoma mansoni rab6-interacting 0.0021 0.0115 0.0115
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0144 0.0805
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.02 0.1114
Brugia malayi beta-NAC-like protein 0.0038 0.0237 0.0479
Entamoeba histolytica hypothetical protein 0.0034 0.0212 0.3189
Brugia malayi Cell death protein 3 precursor 0.0027 0.0157 0.0317
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.0224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0082 0.0574 0.1317
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0082 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0115 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.031 0.031
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0065 0.0065
Loa Loa (eye worm) 6-phosphofructokinase 0.0094 0.0663 0.1339
Echinococcus granulosus o acyltransferase membrane bound domain 0.0034 0.0212 0.0212
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0089 0.0623 0.0623
Trichomonas vaginalis phosphofructokinase, putative 0.0025 0.0147 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0082 0.0455
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0006 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0042 0.027 0.027
Schistosoma mansoni loxhd1 0.0021 0.0115 0.0115
Trichomonas vaginalis ran, putative 0.0023 0.0127 0.0708
Brugia malayi diacylglycerol acyltransferase 0.0203 0.1476 0.2978
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0006 0.0001 0.0007
Schistosoma mansoni rab6-interacting 0.0021 0.0115 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0518 0.119
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0237 0.1609
Brugia malayi cathepsin F-like cysteine proteinase 0.0006 0.0001 0.0002
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0089 0.0623 0.0623
Mycobacterium ulcerans hypothetical protein 0.0023 0.013 0.0106
Schistosoma mansoni apoptosis regulator bax 0.0089 0.0623 0.0623
Trypanosoma brucei unspecified product 0.0052 0.0344 0.0789
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0186 0.0186
Toxoplasma gondii cathepsin B 0.0006 0.0001 0.0007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0191 0.1295
Schistosoma mansoni z-protein (S1r protein) 0.0008 0.0014 0.0014
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0025 0.0147 0.1954
Schistosoma mansoni hypothetical protein 0.033 0.2433 0.2433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.02 0.1114
Toxoplasma gondii cathepsin CPL 0.0032 0.02 0.1354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0186 0.0186
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0434 0.0434
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0434 0.1509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0006 0.0001 0.0002
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0006 0.0001 0.0007
Schistosoma mansoni hypothetical protein 0.0021 0.0115 0.0115
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0082 0.0185
Onchocerca volvulus 0.0032 0.02 0.07
Echinococcus multilocularis Smad4 0.0007 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0017 0.0082 0.1231
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0186 0.0653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0006 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0191 0.0386
Echinococcus granulosus cathepsin L 0.0017 0.0082 0.0082
Leishmania major DNA polymerase eta, putative 0.0073 0.0501 0.1152
Brugia malayi phosphofructokinase 0.0094 0.0663 0.1339
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0186 0.0376
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.031 0.0626
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0025 0.0147 0.2219
Brugia malayi polk-prov protein 0.0023 0.013 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0131
Echinococcus multilocularis bloom syndrome protein 0.0017 0.0085 0.0085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0037 0.0074
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0237 0.0543
Onchocerca volvulus 0.0032 0.02 0.07
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0107 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0212 0.118
Onchocerca volvulus 0.0042 0.027 0.0948
Plasmodium vivax vivapain-1 0.0017 0.0082 0.0553
Brugia malayi ecdysone receptor 0.0014 0.0065 0.0131
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.01 0.0709 0.1628
Schistosoma mansoni dishevelled 0.0008 0.0014 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.02 0.0403
Leishmania major DNA polymerase kappa, putative 0.0075 0.0518 0.119
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.2433 0.491
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0186 0.0186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0434 0.1509
Loa Loa (eye worm) hypothetical protein 0.0031 0.0188 0.038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0191 0.0191
Leishmania major DNA polymerase eta, putative 0.0124 0.0889 0.2042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0075 0.0518 0.0518
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0034 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0006 0.0001 0.0016
Brugia malayi conserved hypotetical protein 0.0014 0.0065 0.0131
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0115 0.0778
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.0376
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0065 0.0131
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0006 0.0001 0.0001
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0006 0.0001 0.0002
Trypanosoma brucei cysteine peptidase C (CPC) 0.0006 0.0001 0.0002
Brugia malayi nuclear receptor NHR-88 0.0031 0.0186 0.0376
Schistosoma mansoni transcription factor btf3 0.0038 0.0237 0.0237
Echinococcus multilocularis caspase 2 0.0027 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0186 0.0376
Entamoeba histolytica hypothetical protein 0.0025 0.0144 0.2175
Schistosoma mansoni regulator of G protein signaling 0.0008 0.0014 0.0014
Trypanosoma cruzi DNA damage repair protein, putative 0.0023 0.013 0.0297
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0073 0.0501 0.3396
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0006 0.0001 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12 nM Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometry ChEMBL. 19507862
IC50 (binding) = 59 nM Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spectrophotometry ChEMBL. 19507862

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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