Detailed information for compound 1088514

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 894.847 | Formula: C42H51N2NaO18
  • H donors: 10 H acceptors: 12 LogP: 0.33 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@@H](O[C@@H]2CCO[C@@H]([C@@H]2O)COCc2ccc(cc2)c2ccccc2)[C@@H]([C@H]([C@H]1O)O[C@@]1(C[C@H](O)[C@H]([C@@H](O1)[C@@H]([C@@H](CNC(=O)c1ccccc1)O)O)NC(=O)O)C(=O)[O-])O.[Na+]
  • InChi: 1S/C42H52N2O18.Na/c45-19-29-34(50)37(35(51)39(60-29)59-28-15-16-58-30(33(28)49)21-57-20-22-11-13-24(14-12-22)23-7-3-1-4-8-23)62-42(40(53)54)17-26(46)31(44-41(55)56)36(61-42)32(48)27(47)18-43-38(52)25-9-5-2-6-10-25;/h1-14,26-37,39,44-51H,15-21H2,(H,43,52)(H,53,54)(H,55,56);/q;+1/p-1/t26-,27+,28+,29+,30+,31+,32+,33+,34-,35+,36+,37-,39+,42-;/m0./s1
  • InChiKey: WUEDKSVPMHRYPJ-SVMGARHNSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus myelin-associated glycoprotein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0133 0.0137
Schistosoma mansoni ran 0.0021 0.0027 0.0028
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Echinococcus multilocularis AMP dependent ligase 0.0041 0.0093 0.0095
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0384
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0028 0.0029
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0133 0.0399 0.3869
Loa Loa (eye worm) hypothetical protein 0.0055 0.0138 0.0132
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0084 0.0086
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0096 0.0094
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0127 0.297
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0016 0.0004
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0084 0.0073
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0049 0.0035
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0044 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0016 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0084 0.0081
Schistosoma mansoni glutaminase 0.0281 0.0887 0.0915
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0087 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0031 0.0026
Giardia lamblia Hypothetical protein 0.0038 0.0084 0.2217
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0119 0.0123
Trichomonas vaginalis AMP dependent ligase, putative 0.0038 0.0084 0.0206
Echinococcus multilocularis GPCR, family 2 0.0081 0.0224 0.0231
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0096 0.2171
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0031 0.0229
Mycobacterium tuberculosis Probable reductase 0.0117 0.0345 0.0355
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0077 0.0062
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0046 0.0048
Brugia malayi Heterochromatin protein 1 0.0072 0.0194 0.0194
Echinococcus multilocularis musashi 0.0056 0.0143 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0028 0.0029
Echinococcus multilocularis chromobox protein 1 0.0072 0.0194 0.02
Echinococcus multilocularis acyl coenzyme A synthetase family 0.0038 0.0084 0.0086
Entamoeba histolytica hypothetical protein 0.0072 0.0195 0.4353
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0076
Echinococcus granulosus RUN 0.0063 0.0164 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0204 0.0633 0.0653
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0077 0.0077
Trichomonas vaginalis chromobox protein, putative 0.0043 0.01 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0164 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0028 0.0028
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0084 0.075
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0049 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0136 0.0407 0.0394
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0036 0.0077 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0031 0.002
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0054 0.1078
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0133 0.0399 0.0385
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0301 0.0311
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Loa Loa (eye worm) fatty acid synthase 0.0026 0.0043 0.0037
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0049 0.0037
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0133 0.0399 0.04
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0031 0.0032
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0143 0.0143
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0049 0.0049
Mycobacterium tuberculosis Putative polyketide synthase Pks16 0.0038 0.0084 0.0081
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0093 0.1701
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0365 0.0376
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0195 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0084 0.007
Leishmania major importin beta-1 subunit, putative 0.0023 0.0034 0.0023
Loa Loa (eye worm) hypothetical protein 0.0049 0.0119 0.0114
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0096 0.0096
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0189
Trichomonas vaginalis AMP dependent ligase, putative 0.0038 0.0084 0.0206
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0388 0.0392
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0133 0.0399 0.3869
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0028 0.0028
Trypanosoma cruzi AMP-binding enzyme, putative 0.0038 0.0084 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0133 0.0399 0.0405
Onchocerca volvulus 0.0133 0.0399 0.1126
Brugia malayi intermediate filament protein 0.0056 0.0143 0.0143
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0056 0.0051
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0038 0.0084 0.0074
Schistosoma mansoni hypothetical protein 0.0174 0.0533 0.055
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0012 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0096 0.0091
Leishmania major hypothetical protein, conserved 0.0038 0.0084 0.0075
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Loa Loa (eye worm) glutathione reductase 0.0051 0.0127 0.0122
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0119 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0133 0.0137
Brugia malayi nuclear hormone receptor 0.0022 0.0028 0.0028
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0133 0.0399 0.0403
Trypanosoma brucei Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative 0.0038 0.0084 0.075
Leishmania major pantothenate kinase subunit, putative 0.0047 0.0112 0.0104
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0104 0.0108
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0049 0.0044
Echinococcus granulosus mitogen activated protein kinase 3 0.0111 0.0323 0.0333
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0012 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0028 0.0023
Plasmodium vivax glutathione reductase, putative 0.0051 0.0127 0.297
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0028 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0141 0.0136
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Mycobacterium ulcerans polyketide synthase 0.0026 0.0044 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0028 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0084 0.0084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0722 0.075
Loa Loa (eye worm) hypothetical protein 0.0133 0.0399 0.0393
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0038 0.0084 0.0206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.253 0.8336 0.8606
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0138 0.0412 0.0425
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0224 0.0224
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0194 0.0539
Brugia malayi AMP-binding enzyme family protein 0.0133 0.0399 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0104 0.0269
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0136 0.0407 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0028 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0031 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0077 0.0065
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.0412 0.0414
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0717 0.074
Echinococcus granulosus snurportin 1 0.0308 0.0977 0.1008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0152 0.0157
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0038 0.0084 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0096 0.0087
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0044 0.0031
Echinococcus granulosus nephrin 0.0022 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.004 0.009 0.0224
Echinococcus granulosus Immunoglobulin 0.0022 0.0029 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0028 0.0029
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.2938 0.9685 1
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0084 0.1852
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0301 0.0301
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0038 0.0084 0.0086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.038 0.0392
Echinococcus multilocularis lipoxygenase domain containing protein 0.0063 0.0164 0.0169
Mycobacterium ulcerans acetyl-CoA synthetase 0.0133 0.0399 0.0385
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0127 0.0119
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0038 0.0084 0.0086
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0031 0.0017
Onchocerca volvulus 0.0036 0.0077 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0028 0.0023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.0027 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0127 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0031 0.002
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0133 0.0399 0.0411
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0041
Schistosoma mansoni hypothetical protein 0.0038 0.0084 0.0086
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Onchocerca volvulus 0.0063 0.0164 0.0411
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.007
Brugia malayi hypothetical protein 0.0019 0.0019 0.0019
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Brugia malayi hypothetical protein 0.0029 0.0054 0.0054
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0136 0.0407 0.0394
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0077 0.0074
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0133 0.0399 0.04
Loa Loa (eye worm) beta-lactamase 0.0036 0.0077 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0399 0.0411
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0388 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Trichomonas vaginalis AMP dependent ligase, putative 0.0038 0.0084 0.0206
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0022 0.0029 0.003
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0138 0.0412 0.0425
Toxoplasma gondii type I fatty acid synthase, putative 0.0066 0.0176 0.4246
Onchocerca volvulus 0.0056 0.0143 0.0348
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Trypanosoma brucei fatty acyl CoA synthetase 3 0.0038 0.0084 0.075
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Brugia malayi hypothetical protein 0.023 0.0717 0.0717
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0052 0.0128 0.2991
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0031 0.0032
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0038 0.0084 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0031 0.0031
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0093 0.0082
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0038 0.0084 0.0206
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Schistosoma mansoni intermediate filament proteins 0.0056 0.0143 0.0147
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0038 0.0084 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0136 0.0407 0.9874
Onchocerca volvulus 0.0049 0.0119 0.0275
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0077 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0028 0.0029
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0084 1
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0084 0.0084
Leishmania major trypanothione reductase 0.0051 0.0127 0.012
Schistosoma mansoni polycystin 1-related 0.0063 0.0164 0.0169
Schistosoma mansoni hypothetical protein 0.0043 0.0099 0.0102
Leishmania major hypothetical protein, unknown function 0.0038 0.0084 0.0075
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0138 0.0131
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0031 0.0017
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0084 0.0075
Schistosoma mansoni hypothetical protein 0.0081 0.0224 0.0231
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0038 0.0084 0.007
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0038 0.0084 0.075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0048
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0119 0.0123
Brugia malayi hypothetical protein 0.0038 0.0084 0.0084
Schistosoma mansoni lamin 0.0056 0.0143 0.0147
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0028 0.0029
Schistosoma mansoni AMP dependent ligase 0.0038 0.0084 0.0086
Mycobacterium ulcerans beta-lactamase 0.0036 0.0077 0.0062
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.0027 0.0013
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0127 0.0131
Mycobacterium ulcerans polyketide synthase 0.0028 0.0049 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0047
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0133 0.0399 1
Echinococcus granulosus expressed conserved protein 0.0098 0.028 0.0289
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0054 0.0043
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0056
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0028 0.0029
Echinococcus granulosus lamin 0.0056 0.0143 0.0147
Echinococcus granulosus chromobox protein 1 0.0072 0.0194 0.02
Leishmania major long chain fatty Acyl CoA synthetase, putative 0.0038 0.0084 0.0075
Plasmodium falciparum glutathione reductase 0.0018 0.0016 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.038 0.0392
Loa Loa (eye worm) hypothetical protein 0.0128 0.038 0.0375
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0084 0.0075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0077 0.0079
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0031 0.0047
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0084 0.1852
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0399 0.0411
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0141 0.0146
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0892 0.2909 0.2906
Trypanosoma brucei fatty acyl CoA syntetase 1 0.0038 0.0084 0.075
Echinococcus granulosus disco interacting protein 2 0.0038 0.0084 0.0086
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0077 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0133 0.0399 0.0405
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0306 0.0316
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0049 0.0045
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0133 0.0399 0.0405
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.038 0.0392
Echinococcus granulosus intermediate filament protein 0.0056 0.0143 0.0147
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0038 0.0084 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0133 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0224 0.0219
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0399 0.0411
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0152 0.0157
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0143 0.0137
Leishmania major hypothetical protein, conserved 0.0036 0.0077 0.0067
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0016 0.0004
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0044 0.0039
Brugia malayi hypothetical protein 0.0038 0.0084 0.0084
Leishmania major fatty acid transporter protein-like protein 0.2899 0.9558 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0096 0.0099
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0028 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0084 0.0073
Schistosoma mansoni FFA transport protein 0.2938 0.9685 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0301 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0133 0.0399 0.0399
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0133 0.0399 0.0393
Brugia malayi N-terminal motif family protein 0.0196 0.0607 0.0607
Onchocerca volvulus 0.0047 0.0112 0.0253
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0029 0.0016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0077 0.0079
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.0027 0.0013
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0133 0.0399 0.04
Echinococcus multilocularis Polycystic kidney disease protein 0.0063 0.0164 0.0169
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.0139 0.0134
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Echinococcus multilocularis long chain fatty acid transport protein 4 0.2938 0.9685 1
Onchocerca volvulus 0.0063 0.0164 0.0411
Plasmodium falciparum thioredoxin reductase 0.0051 0.0127 0.297
Brugia malayi AMP-binding enzyme family protein 0.0158 0.048 0.048
Echinococcus multilocularis protein patched 0.0045 0.0104 0.0108
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0077 0.0074
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0141 0.0141
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0038 0.0084 0.0081
Schistosoma mansoni lamin 0.0056 0.0143 0.0147
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0087 0.0084
Mycobacterium ulcerans hypothetical protein 0.0133 0.0399 0.0385
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0977 0.0972
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0041 0.0037
Plasmodium vivax long-chain fatty acid CoA ligase, putative 0.0038 0.0084 0.1852
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0096 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0028 0.0028
Schistosoma mansoni importin beta-1 0.0029 0.0052 0.0054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0112 0.0112
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0049 0.0037
Loa Loa (eye worm) RNA binding protein 0.0204 0.0633 0.0628
Schistosoma mansoni hypothetical protein 0.0043 0.0099 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0224 0.0224
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0049 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0028 0.0023
Toxoplasma gondii hypothetical protein 0.0038 0.0084 0.1852
Brugia malayi RNA, U transporter 1 0.0082 0.0228 0.0228
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0194 0.0188
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0119 0.0123
Giardia lamblia Long chain fatty acid CoA ligase 4 0.0038 0.0084 0.2217
Onchocerca volvulus 0.0179 0.055 0.1587
Brugia malayi mbt repeat family protein 0.0049 0.0119 0.0119
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.009 0.0186
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0111 0.0323 0.0317
Echinococcus multilocularis RUN 0.0063 0.0164 0.0169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0136 0.0407 0.0394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0022
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0164 0.0169
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0028 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0028 0.0028
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0272 0.0278
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0012 0.0012
Toxoplasma gondii propionate-CoA ligase 0.0133 0.0399 1
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0407 0.0402
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0119 0.0123
Trypanosoma brucei acetyl-CoA synthetase, truncated 0.0038 0.0084 0.075
Schistosoma mansoni lipoxygenase 0.0374 0.1195 0.1234
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0016 0.0004
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0016 0.001
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Schistosoma mansoni rab6-interacting 0.0063 0.0164 0.0169
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0133 0.0399 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0016 0.0091
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0031 0.0032
Leishmania major DNA polymerase kappa, putative 0.0022 0.0031 0.002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0133 0.0399 1
Entamoeba histolytica hypothetical protein 0.0072 0.0195 0.4353
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0028 0.0029
Echinococcus multilocularis conserved hypothetical protein 0.0022 0.0029 0.003
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0038 0.0084 0.007
Schistosoma mansoni ran 0.0021 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0083 0.023 0.0225
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0012 0.0006
Toxoplasma gondii hypothetical protein 0.0052 0.0128 0.2992
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Entamoeba histolytica hypothetical protein 0.0038 0.0084 0.1473
Brugia malayi hypothetical protein 0.0072 0.0195 0.0195
Loa Loa (eye worm) glutaminase 0.0281 0.0887 0.0882
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0041 0.0037
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Trichomonas vaginalis antibiotic synthetase, putative 0.0133 0.0399 0.116
Brugia malayi hypothetical protein 0.0063 0.0164 0.0164
Echinococcus multilocularis transcription factor Dp 1 0.008 0.022 0.0227
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0038 0.0084 0.0206
Onchocerca volvulus 0.0031 0.0061 0.0099
Echinococcus granulosus importin subunit beta 1 0.0029 0.0052 0.0054
Brugia malayi SET domain containing protein 0.0016 0.0011 0.0011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0133 0.0399 0.0385
Schistosoma mansoni hypothetical protein 0.0081 0.0224 0.0231
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0077 0.0074
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0038 0.0084 0.2217
Schistosoma mansoni hypothetical protein 0.0043 0.0099 0.0102
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0133 0.0399 0.0403
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0044 0.003
Entamoeba histolytica hypothetical protein 0.0072 0.0195 0.4353
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0133 0.0128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0084 0.007
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.3033 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0133 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0084 0.0081
Schistosoma mansoni hypothetical protein 0.0063 0.0164 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0076
Echinococcus granulosus mitogen activated protein kinase 0.0111 0.0323 0.0333
Echinococcus granulosus acyl coenzyme A synthetase family 0.0038 0.0084 0.0086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.3033 1 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.0028
Onchocerca volvulus 0.0133 0.0399 0.1126
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0077 0.0184
Toxoplasma gondii exonuclease III APE 0.0042 0.0096 0.2171
Plasmodium vivax importin-beta 2, putative 0.0029 0.0052 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0028 0.0028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0224 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Plasmodium vivax long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1852
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0133 0.0133
Echinococcus multilocularis snurportin 1 0.0308 0.0977 0.1008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Brugia malayi MAP kinase sur-1 0.0111 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0013 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0028 0.0029
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0374 0.1195 0.1234
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0077 0.0079
Loa Loa (eye worm) hypothetical protein 0.0031 0.0061 0.0055
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0133 0.0399 0.0399
Leishmania major long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative 0.0038 0.0084 0.0075
Mycobacterium tuberculosis Conserved protein 0.0036 0.0077 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0133 0.0399 0.0385
Entamoeba histolytica acyl-CoA synthetase, putative 0.0038 0.0084 0.1473
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0052 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0028 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0028 0.0029
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0049 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0028 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.038 0.9523
Echinococcus multilocularis chromobox protein 1 0.0072 0.0194 0.02
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0255 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0038
Schistosoma mansoni hypothetical protein 0.0174 0.0534 0.0551
Onchocerca volvulus 0.0136 0.0407 0.1152
Mycobacterium tuberculosis Conserved protein 0.0036 0.0077 0.0074
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0717 0.074
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.0607 0.1759
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0136 0.0407 0.042
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0028 0.0023
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0106 0.0969
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0031 0.0032
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0038 0.0084 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0127 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0152 0.0138
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0038 0.0084 0.007
Schistosoma mansoni hypothetical protein 0.0174 0.0533 0.055
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0084 0.1852
Echinococcus multilocularis Immunoglobulin 0.0022 0.0029 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0195 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0323 0.093
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Toxoplasma gondii thioredoxin reductase 0.0051 0.0127 0.297
Plasmodium vivax multidomain scavenger receptor, putative 0.0063 0.0164 0.3922
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0096 0.0243
Mycobacterium ulcerans lipase LipD 0.0036 0.0077 0.0062
Giardia lamblia Kinase, CMGC MAPK 0.0111 0.0323 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0052 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0133 0.0399 0.0385
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0195 0.0201
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0119 0.0123
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0054 0.0043
Brugia malayi MH2 domain containing protein 0.0136 0.0407 0.0407
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0087 0.0073
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 0.0038 0.0084 0.007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0028 0.0029
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0038 0.0084 0.0086
Mycobacterium leprae POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) 0.0038 0.0084 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.2132 0.7016 0.7245
Brugia malayi glutaminase DH11.1 0.0281 0.0887 0.0887
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0138 0.0412 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0133 0.0399 0.9646
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0016
Schistosoma mansoni chromobox protein 0.0072 0.0194 0.02
Leishmania major fatty acyl CoA syntetase 1, putative 0.0038 0.0084 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0077 0.0067
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0111 0.0323 0.3117
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0111 0.0323 0.0321
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0136 0.0407 0.042
Schistosoma mansoni hypothetical protein 0.0043 0.0099 0.0102
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0031 0.0032
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0133 0.0137
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0077 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0077 0.0067
Echinococcus granulosus long chain fatty acid transport protein 4 0.2938 0.9685 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0031 0.002
Trypanosoma brucei trypanothione reductase 0.0051 0.0127 0.1178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0028 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0111 0.0111
Echinococcus granulosus transcription factor Dp 1 0.008 0.022 0.0227
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 0.0038 0.0084 0.007
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0034 0.0056
Loa Loa (eye worm) MBCTL1 0.0056 0.0141 0.0136
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0038 0.0084 0.0206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0028 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Brugia malayi isocitrate dehydrogenase 0.0017 0.0012 0.0012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0084 0.007
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0016 0.0091
Plasmodium vivax SET domain protein, putative 0.0128 0.038 0.9523
Brugia malayi Doublecortin family protein 0.0063 0.0164 0.0164
Echinococcus granulosus long chain fatty acid coenzyme A ligase 4 0.0038 0.0084 0.0086
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0345 0.0355
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0028 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0152 0.0157
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0141 0.0146
Loa Loa (eye worm) hypothetical protein 0.023 0.0717 0.0712
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0133 0.0399 0.0393
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0096 0.0099
Echinococcus granulosus geminin 0.0174 0.0533 0.055
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0096 1
Onchocerca volvulus 0.0036 0.0077 0.0146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0345 0.0355
Onchocerca volvulus Fatty acid synthase homolog 0.0047 0.0114 0.0259
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0152 0.0157
Trypanosoma brucei unspecified product 0.0022 0.0031 0.0229
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0136 0.0407 0.042
Echinococcus multilocularis nephrin 0.0022 0.0029 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0028 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0459 0.0462
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0133 0.0399 0.0403
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0028 0.0023
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0012 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.2132 0.7016 0.7245
Plasmodium falciparum glutathione reductase 0.0051 0.0127 0.297
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0133 0.0399 1
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0096 0.2618
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0093 0.009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.007
Plasmodium vivax ATP-dependent acyl-CoA synthetase, putative 0.0038 0.0084 0.1852
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0106 0.0097
Brugia malayi Pre-SET motif family protein 0.0128 0.038 0.038
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0038 0.0084 0.0206
Onchocerca volvulus 0.0036 0.0077 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0031 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0133 0.0399 0.0399
Brugia malayi hypothetical protein 0.0063 0.0164 0.0164
Mycobacterium ulcerans thioesterase 0.0022 0.0029 0.0015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0044 0.0039
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0096 0.0872
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0323 0.093
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Brugia malayi nuclear receptor NHR-88 0.0022 0.0028 0.0028
Onchocerca volvulus 0.014 0.0419 0.1187
Schistosoma mansoni survival motor neuron protein 0.0047 0.0112 0.0115
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0038 0.0084 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0077 0.0074
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0016 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0106
Leishmania major acetyl-CoA synthetase, putative 0.0133 0.0399 0.0405
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0016 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0031 0.0229
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0077 0.0184
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0133 0.0399 0.0411
Brugia malayi Thioredoxin reductase 0.0051 0.0127 0.0127
Schistosoma mansoni chromobox protein 0.0072 0.0194 0.02
Echinococcus granulosus nephrin 0.0022 0.0029 0.003
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0087 0.0084
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0119 0.0275
Trichomonas vaginalis chromobox protein, putative 0.0043 0.01 0.0254
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0104 0.0099
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0152 0.0152
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.0084 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0633 0.0653
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.01 0.0217
Brugia malayi mbt repeat family protein 0.0049 0.0119 0.0119
Leishmania major mitochondrial DNA polymerase beta 0.032 0.1018 0.1053
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0049 0.0037
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0374 0.1195 0.1234
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0084 0.007
Onchocerca volvulus 0.0056 0.0143 0.0348
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0255 0.0801 0.0796
Loa Loa (eye worm) doublecortin family protein 0.0063 0.0164 0.0158
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0388 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0028 0.0029
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0143 0.0137
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0054 0.1078
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0438
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.003
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.2938 0.9685 1
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Trypanosoma brucei fatty acyl CoA synthetase 4 0.0038 0.0084 0.075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0096 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0133 0.0399 0.04
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0194 0.0539
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.1018 0.104
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0323 0.093
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Trichomonas vaginalis esterase, putative 0.0036 0.0077 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0111 0.0323 0.0325
Brugia malayi steroid hormone receptor 0.0022 0.0028 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0028 0.0029
Trichomonas vaginalis set domain proteins, putative 0.1015 0.3317 1
Echinococcus granulosus chromobox protein 1 0.0072 0.0194 0.02
Schistosoma mansoni lipoxygenase 0.0262 0.0823 0.0849
Trypanosoma brucei fatty acyl CoA synthetase 2 0.0038 0.0084 0.075
Echinococcus multilocularis lamin 0.0056 0.0143 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Leishmania major DNA polymerase eta, putative 0.0022 0.0031 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0041 0.0093 0.0078
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0133 0.0399 0.0411
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 0.0038 0.0084 0.0086
Leishmania major 4-coumarate:coa ligase-like protein 0.0133 0.0399 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Loa Loa (eye worm) hypothetical protein 0.004 0.009 0.0084
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0138 0.0412 0.0412
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0016 0.0004
Entamoeba histolytica hypothetical protein 0.0072 0.0195 0.4353
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0028 0.0029
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0016 0.0091
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0038 0.0084 0.0081
Giardia lamblia DINP protein human, muc B family 0.0022 0.0031 0.0501
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0141 0.0146
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0141 0.0146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0077 0.0079
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0084 0.0078
Mycobacterium tuberculosis Conserved protein 0.0036 0.0077 0.0074
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.0412 0.0414
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0388 0.04
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.0624 0.0644
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 4 0.0038 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0099
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0052 0.1037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0384
Schistosoma mansoni acetyl-CoA synthetase 0.0133 0.0399 0.0411
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0028 0.0029
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0016 0.0076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0031 0.0105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0345 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0031 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0028 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0031 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0042 0.0096 0.0099
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0028
Schistosoma mansoni hypothetical protein 0.0081 0.0224 0.0231
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0019 0.0168
Brugia malayi beta-lactamase family protein 0.0036 0.0077 0.0077
Plasmodium falciparum thioredoxin reductase 0.0018 0.0016 0.0091
Mycobacterium ulcerans glutaminase 0.0281 0.0887 0.0874
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0106 0.0097
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0049 0.0044
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0016 0.0001
Schistosoma mansoni hypothetical protein 0.0308 0.0977 0.1008
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0345 0.0347
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0096 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0028 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0077 0.0184
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0152 0.0146
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0028 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0633 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0028 0.0029
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0054 0.1078
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0031 0.0047
Trichomonas vaginalis glutaminase, putative 0.0281 0.0887 0.2638
Brugia malayi ecdysteroid receptor 0.0022 0.0028 0.0028
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0534 0.0534
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0044 0.003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0138 0.0412 0.0407
Echinococcus granulosus AMP dependent ligase 0.0041 0.0093 0.0095
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0119 0.0123
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0224 0.0231
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0047 0.0112 0.0103
Brugia malayi glutathione reductase 0.0051 0.0127 0.0127
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0038 0.0084 0.2217
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0028 0.0029
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0133 0.0399 0.0403
Echinococcus multilocularis mitogen activated protein kinase 0.0111 0.0323 0.0333
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0077 0.0062
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.038 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0633 0.0653
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0052 0.0438
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0044 0.0039
Trypanosoma brucei acyl-CoA synthetase, putative 0.0038 0.0084 0.075
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.2899 0.9558 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0119 0.0114
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0084 0.1852
Schistosoma mansoni hypothetical protein 0.0081 0.0224 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0028 0.0028
Brugia malayi cDNA sequence BC018371 0.0038 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0028 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0204 0.0633 0.0633
Plasmodium falciparum LCCL domain-containing protein 0.0063 0.0164 0.3922
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Echinococcus multilocularis lamin dm0 0.0056 0.0143 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0407 0.0402
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Mycobacterium tuberculosis Probable fatty acyl-AMP ligase MbtM 0.0038 0.0084 0.0081
Leishmania major acetyl-CoA synthetase, putative 0.0133 0.0399 0.0405
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0084 0.1852
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0044 0.003
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0633 0.0653
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0031 0.0229
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0399 0.0411
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0224 0.0231
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.1018 0.104
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0084 0.007
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0301 0.7116
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0044 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0016 0.0016
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0038 0.0084 0.075
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0136 0.0407 0.0394
Treponema pallidum long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.8466
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0038 0.0084 0.0086
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0056 0.0143 0.0137
Echinococcus granulosus tar DNA binding protein 0.0204 0.0633 0.0653
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0038 0.0084 0.0074
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0084 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0323 0.0321
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0136 0.0407 0.0412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0133 0.0137
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0077 0.0071
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0044 0.0044
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0133 0.0399 0.0411
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0084 0.1852
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0084 0.0073
Brugia malayi beta-lactamase family protein 0.0036 0.0077 0.0077
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0459 0.4465
Mycobacterium ulcerans hypothetical protein 0.0169 0.0516 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0892 0.2909 0.2909
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0323 0.0333
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0301 0.0311
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.038 0.0392
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0096 0.0088
Echinococcus multilocularis dna polymerase eta 0.0022 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0133 0.0399 0.0399
Brugia malayi beta-lactamase 0.0036 0.0077 0.0077
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0152 0.3614
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0028 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0516 0.0533
Echinococcus granulosus dna polymerase kappa 0.0022 0.0031 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0054 0.1078
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0084 0.007
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0104 0.0108
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0056 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0028 0.0028
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0084 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0152 0.0138
Echinococcus granulosus GPCR family 2 0.0081 0.0224 0.0231
Toxoplasma gondii ABC1 family protein 0.0036 0.0077 0.1665
Loa Loa (eye worm) hypothetical protein 0.0174 0.0534 0.0529
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0111 0.0323 0.0321
Echinococcus granulosus lamin dm0 0.0056 0.0143 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0077 0.0184
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0449 0.0463
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0111 0.0323 0.8036
Mycobacterium leprae Probable lipase LipE 0.0036 0.0077 0.0065
Echinococcus granulosus microtubule associated protein 2 0.2132 0.7016 0.7245
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0138 0.0412 0.0419
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0028 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Brugia malayi TAR-binding protein 0.0204 0.0633 0.0633
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0029 0.0015
Trypanosoma brucei protein kinase, putative 0.0111 0.0323 0.3117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0136 0.0407 0.0407
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0449 0.0463
Schistosoma mansoni hypothetical protein 0.0072 0.0195 0.0201
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0133 0.0399 0.0411
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0138 0.0412 0.0425
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.0624 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.004 0.009 0.0224
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0204 0.0633 0.0628
Brugia malayi chromobox protein homolog 3 0.004 0.009 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.2899 0.9558 1
Mycobacterium leprae Putative polyketide synthetase Pks16 0.0038 0.0084 0.0073
Schistosoma mansoni ap endonuclease 0.0042 0.0096 0.0099
Loa Loa (eye worm) glutaminase 2 0.0281 0.0887 0.0882
Loa Loa (eye worm) hypothetical protein 0.0063 0.0164 0.0158
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0323 0.093
Onchocerca volvulus 0.1015 0.3317 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0029 0.0024
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0038 0.0084 0.0086
Schistosoma mansoni hypothetical protein 0.0047 0.0112 0.0115
Loa Loa (eye worm) hypothetical protein 0.0133 0.0399 0.0393
Loa Loa (eye worm) hypothetical protein 0.0196 0.0607 0.0602
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0031 0.0026
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0038 0.0084 0.007
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0028 0.0029
Trichomonas vaginalis antibiotic synthetase, putative 0.0133 0.0399 0.116
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0016 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0028 0.0028
Echinococcus granulosus Polycystic kidney disease protein 0.0063 0.0164 0.0169
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Brugia malayi CHE-14 protein 0.0045 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0031 0.0229
Entamoeba histolytica acyl-coA synthetase, putative 0.0133 0.0399 0.9646
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0133 0.0399 0.0385
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0034 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0133 0.0399 0.0399
Schistosoma mansoni rab6-interacting 0.0063 0.0164 0.0169
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0096 0.2171
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Onchocerca volvulus 0.0038 0.0084 0.0168
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0038 0.0084 0.2217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0016 0.0004
Schistosoma mansoni DNA polymerase eta 0.0022 0.0031 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0028 0.0028
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0084 0.1852
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0106 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0084 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.014 0.0419 0.0432
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0158 0.048 0.0496
Leishmania major fatty acyl CoA synthetase 2, putative 0.0038 0.0084 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Echinococcus granulosus irregular chiasm roughest protein 0.0022 0.0029 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0031 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0077 0.1665
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0133 0.0399 0.0411
Schistosoma mansoni coup transcription factor 0.0022 0.0028 0.0029
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0111 0.0323 0.0325
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0016 0.0091
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0141 0.0146
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0104 0.0108
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0019 0.0014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0459 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0204 0.0633 0.0653
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0041 0.0093 0.0078
Trypanosoma brucei pantothenate kinase subunit, putative 0.0038 0.0084 0.075
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0084 0.1852
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0133 0.0399 0.0385
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.038 0.0392
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0096 0.0082
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0078
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0345 0.0355
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0056
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.0412 0.4004
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0084 0.0073
Brugia malayi Calcitonin receptor-like protein seb-1 0.0255 0.0801 0.0801
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086
Loa Loa (eye worm) TAR-binding protein 0.0204 0.0633 0.0628
Leishmania major hypothetical protein, conserved 0.0029 0.0054 0.0044
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0046 0.0048
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0111 0.0323 0.0321
Loa Loa (eye worm) hypothetical protein 0.0063 0.0164 0.0158
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0158 0.048 0.0475
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0054 0.0454
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0012 0.0012
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0096 0.1793
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0133 0.0399 0.0385
Schistosoma mansoni loxhd1 0.0063 0.0164 0.0169
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0038 0.0084 0.0074
Echinococcus granulosus dna polymerase eta 0.0022 0.0031 0.0032
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0122 0.0122
Echinococcus multilocularis mitogen activated protein kinase 3 0.0111 0.0323 0.0333
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0031 0.002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0224 0.0231
Echinococcus multilocularis protein dispatched 1 0.0051 0.0125 0.0129
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0136 0.0407 0.042
Echinococcus multilocularis expressed conserved protein 0.0098 0.028 0.0289
Onchocerca volvulus 0.0158 0.048 0.1373
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0042
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0038 0.0084 0.0206
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0077 0.0679
Loa Loa (eye worm) hypothetical protein 0.0081 0.0224 0.0219
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0038 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0026
Schistosoma mansoni hypothetical protein 0.0306 0.0971 0.1003
Mycobacterium ulcerans acyl-CoA synthetase 0.0133 0.0399 0.0385
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0152 0.0138
Giardia lamblia Long chain fatty acid CoA ligase, putative 0.0038 0.0084 0.2217
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0133 0.0399 0.9646
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0084 0.007
Echinococcus granulosus lipoxygenase domain containing protein 0.0063 0.0164 0.0169
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0345 0.0355
Schistosoma mansoni patched 1 0.0045 0.0104 0.0108
Loa Loa (eye worm) oxidoreductase 0.0133 0.0399 0.0393
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0255 0.0801 0.0796
Brugia malayi hypothetical protein 0.0028 0.0049 0.0049
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0016 0.0091
Echinococcus multilocularis geminin 0.0174 0.0533 0.055
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0084 0.0078
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0038 0.0084 0.2217
Plasmodium falciparum importin beta, putative 0.0029 0.0052 0.1037
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0084 0.0084
Brugia malayi RNA binding protein 0.0204 0.0633 0.0633
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0028 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0133 0.0137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0084 0.007
Loa Loa (eye worm) hypothetical protein 0.0133 0.0399 0.0393
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0049 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0127 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0028 0.0023
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0084 0.1473
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0038 0.0084 0.0086

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 4.44 uM Binding affinity to mouse MAGd1-3Fc expressed in CHO-Lec 3.2.8.1 cells by SPR analysis ChEMBL. 20095613
Ratio (binding) = 0.7 Inhibition of mouse MAGd1-3Fc expressed in CHO-Lec 3.2.8.1 cells by hepten inhibition assay relative to sodium-(2R,4S,5R,6R)-5-acetamido-2-(benzyloxy)-6-((1S,2R)-3-(4-chlorobenzamido)-1,2-dihydroxypropyl)-4-hydroxytetrahydro-2H-pyran-2-carboxylate ChEMBL. 20095613

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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