Detailed information for compound 1106699

Basic information

Technical information
  • TDR Targets ID: 1106699
  • Name: (E)-3-[1-(2-diethylaminoethyl)-2-propylbenzim idazol-5-yl]-N-hydroxyprop-2-enamide
  • MW: 344.451 | Formula: C19H28N4O2
  • H donors: 2 H acceptors: 3 LogP: 2.55 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc2c(n1CCN(CC)CC)ccc(c2)/C=C/C(=O)NO
  • InChi: 1S/C19H28N4O2/c1-4-7-18-20-16-14-15(9-11-19(24)21-25)8-10-17(16)23(18)13-12-22(5-2)6-3/h8-11,14,25H,4-7,12-13H2,1-3H3,(H,21,24)/b11-9+
  • InChiKey: UATJOHRKUKXMDS-PKNBQFBNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[1-(2-diethylaminoethyl)-2-propyl-benzimidazol-5-yl]prop-2-enehydroxamic acid
  • (E)-3-[1-(2-diethylaminoethyl)-2-propyl-5-benzimidazolyl]prop-2-enehydroxamic acid
  • (E)-3-[1-(2-diethylaminoethyl)-2-propyl-benzimidazol-5-yl]-N-hydroxy-prop-2-enamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0063 0.0123
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0003
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.004 0.004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0058 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0258 0.0258
Echinococcus granulosus orexin receptor type 2 0.0028 0.0036 0.0036
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.013 0.1539
Brugia malayi MBOAT family protein 0.0446 0.0845 0.0845
Echinococcus granulosus geminin 0.0167 0.0305 0.0305
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0036 0.0393
Brugia malayi Muscleblind-like protein 0.0298 0.0557 0.0557
Schistosoma mansoni amine GPCR 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0054 0.0054
Trypanosoma brucei histone deacetylase 2 0.0022 0.0024 0.0047
Loa Loa (eye worm) hypothetical protein 0.0288 0.0538 0.0536
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Schistosoma mansoni hypothetical protein 0.0151 0.0274 0.0274
Onchocerca volvulus 0.003 0.004 0.0443
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.004 0.004
Schistosoma mansoni histone deacetylase hda2 0.0022 0.0024 0.0024
Onchocerca volvulus 0.0019 0.0018 0.0174
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0107 0.0211
Echinococcus multilocularis expressed protein 0.0037 0.0054 0.0054
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0024 0.0047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0036 0.0036
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0036 0.0036
Echinococcus granulosus neuropeptide s receptor 0.0481 0.0911 0.0911
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0024 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0066
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.0472 0.0472
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0036 0.0036
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0052 0.0102
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0036 0.0036
Leishmania major phosphoglycerate kinase C, glycosomal 0.0204 0.0376 0.0731
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0019
Echinococcus multilocularis cpg binding protein 0.0067 0.0112 0.0112
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0036 0.0036
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0003 0.0003
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0126 0.0123
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.518 1 1
Brugia malayi hypothetical protein 0.003 0.004 0.004
Onchocerca volvulus 0.003 0.004 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0156 0.0156
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0062 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0036 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0179 0.0328 0.0328
Brugia malayi RE15519p 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0064 0.0105 0.121
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0018 0.0174
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0036 0.0036
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0003
Loa Loa (eye worm) histone deacetylase 1 0.0077 0.013 0.0127
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0052 0.0578
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0036 0.0036
Toxoplasma gondii histone deacetylase HDAC3 0.0077 0.013 0.1506
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0126 0.0247
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.054 0.6145
Onchocerca volvulus 0.0042 0.0062 0.0705
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0156 0.0283 0.0283
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Onchocerca volvulus 0.0019 0.0018 0.0174
Echinococcus granulosus histone deacetylase 6 0.0022 0.0024 0.0024
Echinococcus granulosus histone deacetylase 8 0.0022 0.0024 0.0024
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0126 0.0248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0015
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0179 0.0328 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0036 0.0036
Brugia malayi Latrophilin receptor protein 2 0.007 0.0117 0.0117
Schistosoma mansoni loxhd1 0.0042 0.0062 0.0062
Echinococcus multilocularis zinc finger protein 0.4733 0.9137 0.9137
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0036 0.0033
Leishmania major phosphoglycerate kinase B, cytosolic 0.0204 0.0376 0.0731
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0117 0.0117
Leishmania major histone deacetylase, putative 0.0077 0.013 0.0249
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0062 0.0062
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0446 0.0845 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0058 0.0682
Brugia malayi beta-lactamase family protein 0.0042 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0008 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0156 0.0156
Brugia malayi beta-lactamase 0.0042 0.0063 0.0063
Echinococcus granulosus histone deacetylase 1 0.0077 0.013 0.013
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0003
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Leishmania major cytochrome p450-like protein 0.0023 0.0025 0.0043
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0167 0.0305 0.0305
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0117 0.0114
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0179 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0179 0.0328 0.0325
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0036 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.004 0.004
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus granulosus GPCR family 2 0.007 0.0117 0.0117
Leishmania major cathepsin L-like protease 0.0071 0.0119 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Onchocerca volvulus 0.0028 0.0036 0.0393
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Trypanosoma brucei C-8 sterol isomerase, putative 0.2646 0.5099 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0208 0.0205
Schistosoma mansoni amine GPCR 0.0028 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Brugia malayi Histone deacetylase family protein 0.0022 0.0024 0.0024
Schistosoma mansoni biogenic amine receptor 0.0028 0.0036 0.0036
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0063 0.0706
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0446 0.0845 0.0845
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0382 0.0379
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Onchocerca volvulus 0.003 0.004 0.0443
Brugia malayi Dopamine receptor protein 1 0.0028 0.0036 0.0036
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.013 0.1539
Schistosoma mansoni hypothetical protein 0.007 0.0117 0.0117
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0008 0.0016
Entamoeba histolytica phosphoglycerate kinase, putative 0.0204 0.0376 0.4448
Onchocerca volvulus 0.0028 0.0036 0.0393
Echinococcus multilocularis geminin 0.0167 0.0305 0.0305
Schistosoma mansoni amine GPCR 0.0028 0.0036 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0036 0.0036
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0119 0.0119
Leishmania major cathepsin L-like protease 0.0071 0.0119 0.0228
Brugia malayi Pre-SET motif family protein 0.0031 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0058 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0003 0.0003
Trypanosoma brucei histone deacetylase 1 0.0077 0.013 0.0255
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0036 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0063 0.0743
Brugia malayi GnHR receptor homolog 0.0028 0.0036 0.0036
Brugia malayi cytochrome P450 0.0014 0.0008 0.0008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0126 0.0248
Loa Loa (eye worm) voltage-dependent calcium channel 0.0054 0.0086 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Conserved protein 0.0042 0.0063 0.1103
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.0048 0.0074 0.0837
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0036 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0056 0.0662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0041 0.0041
Echinococcus multilocularis histone deacetylase 1 0.0077 0.013 0.013
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0446 0.0845 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0446 0.0845 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0446 0.0845 0.0845
Echinococcus granulosus g protein coupled receptor 0.0028 0.0036 0.0036
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0025 0.0455
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0006 0.0006
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0056 0.0662
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.0126 0.0247
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0081 0.0078
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0003
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.004 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0063 0.1103
Brugia malayi G protein-coupled receptor 0.0028 0.0036 0.0036
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0446 0.0845 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0036 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0036 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0063 0.0063
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.004 0.004
Mycobacterium leprae Probable lipase LipE 0.0042 0.0063 0.1481
Loa Loa (eye worm) hypothetical protein 0.0221 0.041 0.0407
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0451 0.0854 0.0854
Leishmania major cytochrome p450-like protein 0.0014 0.0008 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0077 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.2646 0.5099 0.5097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0036 0.0033
Plasmodium falciparum histone deacetylase, putative 0.0022 0.0024 0.0281
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0245 0.0245
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0058 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0119 0.0119
Echinococcus multilocularis serotonin transporter 0.0179 0.0328 0.0328
Plasmodium vivax vivapain-2 0.0019 0.0018 0.0208
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.004 0.004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0119 0.0119
Schistosoma mansoni lipoxygenase 0.0179 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Onchocerca volvulus 0.0028 0.0036 0.0393
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0156 0.0283 0.0283
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0062 0.0059
Brugia malayi histone deacetylase 1 (HD1) 0.0077 0.013 0.013
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0036 0.0036
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0036 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0063 0.0743
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0003 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0126 0.0126
Toxoplasma gondii hypothetical protein 0.0446 0.0845 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0126 0.0241
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0003 0.0003
Plasmodium vivax histone deacetylase 1, putative 0.0077 0.013 0.1539
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0054 0.0639
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni histamine h1 receptor 0.0028 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0028
Trichomonas vaginalis helicase, putative 0.0014 0.0009 0.011
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.054 1
Onchocerca volvulus 0.0028 0.0036 0.0393
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0117 0.0114
Schistosoma mansoni adenoreceptor 0.0028 0.0036 0.0036
Echinococcus multilocularis RUN 0.0042 0.0062 0.0062
Brugia malayi neuropeptide F receptor 0.0028 0.0036 0.0036
Brugia malayi CXXC zinc finger family protein 0.0064 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Toxoplasma gondii transporter, cation channel family protein 0.0054 0.0086 0.0988
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0063 0.1481
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0028 0.0036 0.0393
Trypanosoma cruzi GUP1, putative 0.0446 0.0845 0.1657
Schistosoma mansoni neuropeptide receptor 0.0028 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Brugia malayi diacylglycerol acyltransferase 0.0446 0.0845 0.0845
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0003 0.0003
Schistosoma mansoni sodium-dependent amino acid transporter 0.003 0.004 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0041 0.0041
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0018 0.0018
Brugia malayi Cytochrome P450 family protein 0.0023 0.0025 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0208
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0446 0.0845 0.0845
Onchocerca volvulus 0.0031 0.0041 0.0454
Entamoeba histolytica vacuolar protein sorting 26 0.0446 0.0845 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0054 0.0106
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0025 0.0022
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0062 0.0737
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0204 0.0376 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Schistosoma mansoni opsin-like receptor 0.0028 0.0036 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0003 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0054 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Brugia malayi MBOAT family protein 0.0446 0.0845 0.0845
Echinococcus granulosus cathepsin l1 0.0013 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0013 0.0006 0.0032
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Trichomonas vaginalis porcupine, putative 0.0446 0.0845 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0446 0.0845 0.0842
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0065 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0156 0.0156
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0126 0.1495
Schistosoma mansoni biogenic amine (5HT) receptor 0.0288 0.0538 0.0538
Brugia malayi sulfakinin receptor protein 0.0028 0.0036 0.0036
Mycobacterium ulcerans beta-lactamase 0.0042 0.0063 0.1481
Loa Loa (eye worm) cysteine protease 0.0019 0.0018 0.0015
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0063 0.1103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0063 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Trypanosoma brucei phosphoglycerate kinase 0.0204 0.0376 0.0737
Toxoplasma gondii exonuclease III APE 0.0038 0.0054 0.0602
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0036 0.0036
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0126 0.0247
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Chlamydia trachomatis phosphoglycerate kinase 0.0204 0.0376 1
Echinococcus multilocularis sex peptide receptor 0.0028 0.0036 0.0036
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0126 0.0248
Onchocerca volvulus 0.0028 0.0036 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0058 0.0682
Leishmania major histone deacetylase, putative 0.0022 0.0024 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0054 0.0639
Onchocerca volvulus 0.0042 0.0062 0.0705
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Echinococcus granulosus muscleblind protein 0.0298 0.0557 0.0557
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0041 0.0449
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0063 0.0706
Echinococcus granulosus tm gpcr rhodopsin 0.0528 0.1003 0.1003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Trypanosoma brucei histone deacetylase, putative 0.0022 0.0024 0.0047
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.003 0.004 0.0438
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0058 0.0682
Schistosoma mansoni histone deacetylase 4 5 0.0022 0.0024 0.0024
Trichomonas vaginalis transmembrane protein nessy, putative 0.0446 0.0845 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0254 0.6692
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0446 0.0845 0.0845
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1756 0.3378 0.3378
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0156 0.0283 0.0283
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0446 0.0845 0.0845
Onchocerca volvulus 0.0028 0.0036 0.0393
Schistosoma mansoni hypothetical protein 0.0446 0.0845 0.0845
Schistosoma mansoni hypothetical protein 0.007 0.0117 0.0117
Brugia malayi larval opioid receptor 0.0028 0.0036 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0054 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0446 0.0845 1
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0008 0.0008
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0156 0.0283 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0845 1
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Brugia malayi Pre-SET motif family protein 0.0207 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.0117 0.0208 0.0208
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0528 0.1003 0.1003
Onchocerca volvulus 0.0019 0.0018 0.0174
Echinococcus multilocularis histone deacetylase 7 0.0022 0.0024 0.0024
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0024 0.0024
Plasmodium falciparum histone deacetylase 1 0.0077 0.013 0.1539
Echinococcus granulosus uncharacterized sodium dependent transporter 0.003 0.004 0.004
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0041 0.0041
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2646 0.5099 0.5099
Loa Loa (eye worm) hypothetical protein 0.0402 0.076 0.0757
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0119 0.0234
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0018 0.0208
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0204 0.0376 0.0737
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0446 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.004 0.004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.004 0.0438
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0036 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Echinococcus granulosus o acyltransferase membrane bound domain 0.0446 0.0845 0.0845
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0018 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Mycobacterium tuberculosis Conserved protein 0.0042 0.0063 0.1103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.0066
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0036 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0041 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0063 0.1481
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0054 0.0086 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0042 0.0063 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0258 0.0258
Echinococcus granulosus cathepsin l1 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus RUN 0.0042 0.0062 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0018 0.0028
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0156 0.0283 0.0283
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0024 0.0047
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0003
Schistosoma mansoni polycystin 1-related 0.0042 0.0062 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0446 0.0845 0.1651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Toxoplasma gondii cathepsin CPL 0.0019 0.0018 0.0169
Onchocerca volvulus 0.0019 0.0018 0.0174
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0156 0.0283 0.0283
Echinococcus multilocularis serotonin receptor 0.0288 0.0538 0.0538
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus multilocularis phosphoglycerate kinase 1 0.0204 0.0376 0.0376
Onchocerca volvulus 0.0042 0.0063 0.0711
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0119 0.0234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0018 0.0015
Onchocerca volvulus 0.0028 0.0036 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Loa Loa (eye worm) hypothetical protein 0.0446 0.0845 0.0842
Echinococcus granulosus somatostatin receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0446 0.0845 0.0842
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0071 0.0119 0.0119
Echinococcus granulosus histone deacetylase 0.0022 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1412
Echinococcus granulosus sterol O acyltransferase 1 0.0446 0.0845 0.0845
Onchocerca volvulus 0.0179 0.0328 0.3862
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0179 0.0328 0.0328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Echinococcus multilocularis histone deacetylase 3 0.0077 0.013 0.013
Trypanosoma cruzi glycerol uptake protein, putative 0.0446 0.0845 0.1657
Echinococcus granulosus fmrfamide receptor 0.0028 0.0036 0.0036
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0058 0.0074
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.0911 0.0911
Mycobacterium ulcerans lipase LipD 0.0042 0.0063 0.1481
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.004 0.0037
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Echinococcus granulosus zinc finger protein 0.4733 0.9137 0.9137
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus histone deacetylase 6 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus g protein coupled receptor 0.0028 0.0036 0.0036
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0156 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0018 0.0034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0003 0.0003
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0204 0.0376 0.0737
Onchocerca volvulus 0.0019 0.0018 0.0174
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0063 0.1103
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0058 0.0113
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.013 0.1539
Loa Loa (eye worm) hypothetical protein 0.0048 0.0074 0.0071
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0204 0.0376 1
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.0854 0.0854
Brugia malayi steroid hormone receptor 0.0011 0.0003 0.0003
Schistosoma mansoni sterol O-acyltransferase 1 0.0446 0.0845 0.0845
Brugia malayi Dopamine receptor 0.0028 0.0036 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0003 0.0003
Echinococcus granulosus voltage dependent calcium channel 0.0054 0.0086 0.0086
Loa Loa (eye worm) cytochrome P450 0.0014 0.0008 0.0005
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0008 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0036 0.0036
Trypanosoma brucei histone deacetylase 4 0.0022 0.0024 0.0047
Brugia malayi G-protein coupled receptor 0.0028 0.0036 0.0036
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0052 0.0102
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0063 0.1103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0062 0.0062
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0036 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0036 0.0036
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0167 0.0305 0.0305
Echinococcus granulosus expressed protein 0.0037 0.0054 0.0054
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0003
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.0126 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.003 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Schistosoma mansoni histone deacetylase hda2 0.0022 0.0024 0.0024
Schistosoma mansoni ap endonuclease 0.0038 0.0054 0.0054
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0126 0.0241
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0003 0.0003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0036 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Echinococcus granulosus allatostatin A receptor 0.0028 0.0036 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0063 0.1103
Echinococcus multilocularis somatostatin receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.518 1 1
Echinococcus granulosus sex peptide receptor 0.0028 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0028 0.0036 0.0036
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0036 0.0036
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0024 0.0024
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0063 0.0742
Schistosoma mansoni sodium/chloride dependent transporter 0.003 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0036 0.0036
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0036 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Echinococcus multilocularis serotonin receptor 0.0288 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Loa Loa (eye worm) hypothetical protein 0.0151 0.0274 0.0271
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Leishmania major glycerol uptake protein, putative 0.0446 0.0845 0.1651
Brugia malayi follicle stimulating hormone receptor 0.0543 0.1032 0.1032
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0054 0.1242
Plasmodium vivax histone deacetylase, putative 0.0022 0.0024 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0006 0.0066
Echinococcus multilocularis muscleblind protein 0.0298 0.0557 0.0557
Giardia lamblia Phosphoglycerate kinase 0.0204 0.0376 0.6621
Echinococcus multilocularis sterol O acyltransferase 1 0.0446 0.0845 0.0845
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0254 0.6692
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Echinococcus multilocularis histone deacetylase 8 0.0022 0.0024 0.0024
Schistosoma mansoni coup transcription factor 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus o acyltransferase membrane bound domain 0.0446 0.0845 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0845 1
Echinococcus granulosus hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0402 0.076 0.0757
Brugia malayi MBOAT family protein 0.0446 0.0845 0.0845
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Brugia malayi putative neuropeptide receptor 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0028 0.0036 0.0393
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0063 0.0063
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.0126 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0074 0.0071
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.003 0.004 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0446 0.0845 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Loa Loa (eye worm) hypothetical protein 0.0054 0.0086 0.0084
Leishmania major glycerol uptake protein, putative 0.0446 0.0845 0.1651
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0018 0.0174
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0025 0.0049
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0254 0.4986
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0018 0.0174
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0204 0.0376 0.745
Echinococcus granulosus g protein coupled receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Plasmodium falciparum transporter, putative 0.003 0.004 0.0476
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0063 0.0742
Leishmania major histone deacetylase, putative 0.0077 0.013 0.0249
Entamoeba histolytica histone deacetylase, putative 0.0077 0.013 0.1539
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.041 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni zinc finger protein 0.518 1 1
Loa Loa (eye worm) acetyltransferase 0.0143 0.0258 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0028 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.0067 0.0112 0.0112
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0028
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0036 0.0033
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0156 0.0156
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0054 0.0051
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0018 0.0018
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0024 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trypanosoma cruzi glycerol uptake protein, putative 0.0446 0.0845 0.1657
Plasmodium vivax amine transporter, putative 0.003 0.004 0.0476
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0204 0.0376 0.4426
Echinococcus multilocularis sodium and chloride dependent glycine 0.003 0.004 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0054 0.0635
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0008 0.001
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0126 0.0126
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0208
Toxoplasma gondii hypothetical protein 0.003 0.004 0.0438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Brugia malayi Doublecortin family protein 0.0042 0.0062 0.0062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0003 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0063 0.0063
Treponema pallidum sodium- and chloride- dependent transporter 0.0179 0.0328 0.3466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0003 0.0003
Loa Loa (eye worm) histone deacetylase 7A 0.0022 0.0024 0.0021
Loa Loa (eye worm) fibroinase 0.0019 0.0018 0.0015
Mycobacterium ulcerans phosphoglycerate kinase 0.0204 0.0376 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0058 0.0058
Loa Loa (eye worm) ctsf protein 0.0019 0.0018 0.0015
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.003 0.004 0.0037
Echinococcus granulosus histone deacetylase 3 0.0077 0.013 0.013
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0036 0.0036
Trypanosoma brucei glycerol uptake protein, putative 0.0446 0.0845 0.1657
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0126 0.0126
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Leishmania major glycerol uptake protein, putative 0.0446 0.0845 0.1651
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0036 0.0036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0058 0.0106
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0036 0.0033
Treponema pallidum alginate O-acetylation protein (algI) 0.0446 0.0845 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0156 0.0156
Schistosoma mansoni cpg binding protein 0.0064 0.0105 0.0105
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.025 0.025
Loa Loa (eye worm) beta-lactamase 0.0042 0.0063 0.006
Leishmania major C-8 sterol isomerase-like protein 0.2646 0.5099 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0036 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Treponema pallidum phosphoglycerate kinase 0.0204 0.0376 0.4069
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0117 0.0117
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0018 0.0018
Plasmodium falciparum histone deacetylase 2 0.0022 0.0024 0.0281
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0036 0.0036
Schistosoma mansoni lipoxygenase 0.0104 0.0182 0.0182
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0179 0.0328 0.0328
Brugia malayi Cytochrome P450 family protein 0.0052 0.0081 0.0081
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Loa Loa (eye worm) histone deacetylase 11 0.0022 0.0024 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0018 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0036 0.0036
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.003 0.004 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0054 0.0639
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0036 0.0036
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0036 0.0036
Schistosoma mansoni opsin-like receptor 0.0028 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi ecdysteroid receptor 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Brugia malayi Serotonin receptor 0.0526 0.0999 0.0999
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0058 0.0058
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0054 0.0639
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0063 0.0063
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.009 0.0176
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0036 0.0036
Brugia malayi hypothetical protein 0.0402 0.076 0.076
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0063 0.0123
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi AKH receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0117 0.0117
Brugia malayi Dopamine receptor protein 2 0.0028 0.0036 0.0036
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0119 0.0234
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0054 0.0054
Trichomonas vaginalis rotamase, putative 0.0036 0.0052 0.0614
Brugia malayi Serotonin receptor 0.0028 0.0036 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0204 0.0376 0.4448
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0006 0.0006
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0036 0.0036
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0054 0.0051
Plasmodium vivax SET domain protein, putative 0.0031 0.0041 0.0486
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0204 0.0376 0.4426
Echinococcus granulosus serotonin receptor 0.0028 0.0036 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0288 0.0538 0.0538
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0446 0.0845 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0052 0.0614
Echinococcus granulosus sodium and chloride dependent glycine 0.003 0.004 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0117 0.0117
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0446 0.0845 0.0845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0054 0.0054
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.032 0.3794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0003 0.0003
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0025 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0298 0.0557 0.0555
Schistosoma mansoni hypothetical protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) MBOAT family protein 0.518 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0022 0.0024 0.0024
Brugia malayi histone deacetylase 11 0.0022 0.0024 0.0024
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0036 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0025 0.0049
Schistosoma mansoni histone deacetylase 1 2 3 0.0022 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Mycobacterium ulcerans hypothetical protein 0.0042 0.0063 0.1481
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Plasmodium falciparum phosphoglycerate kinase 0.0204 0.0376 0.4448
Schistosoma mansoni neuropeptide receptor 0.0028 0.0036 0.0036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0224 0.2624
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0018 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0025 0.0022
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0036 0.0036
Schistosoma mansoni opsin-like receptor 0.0028 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0003 0.0003
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0058 0.0058
Echinococcus multilocularis histone deacetylase 0.0022 0.0024 0.0024
Mycobacterium tuberculosis Conserved protein 0.0042 0.0063 0.1103
Echinococcus granulosus cpg binding protein 0.0067 0.0112 0.0112
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0059
Leishmania major histone deacetylase, putative 0.0022 0.0024 0.004
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0054 0.0086 0.017
Trypanosoma cruzi histone deacetylase, putative 0.0022 0.0024 0.0047
Onchocerca volvulus 0.0028 0.0036 0.0393
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.0501 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.013 0.0255
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0446 0.0845 0.0845
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0058 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Brugia malayi MBOAT family protein 0.0446 0.0845 0.0845
Brugia malayi neuropeptide F receptor 0.0028 0.0036 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0054 0.0639
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.0472 0.5585
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0036 0.0033
Plasmodium vivax histone deacetylase, putative 0.0022 0.0024 0.0281
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Brugia malayi hypothetical protein 0.0042 0.0062 0.0062
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0052 0.0095
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0063 0.1103
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0009 0.011
Brugia malayi Phosphoglycerate kinase 0.0204 0.0376 0.0376
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0022
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0204 0.0376 0.4448
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0058 0.0682
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0063 0.0123
Giardia lamblia Histone deacetylase 0.0077 0.013 0.1565
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0119 0.0234
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.013 0.1539
Echinococcus granulosus neuropeptide receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0018 0.0018
Plasmodium vivax vivapain-2 0.0019 0.0018 0.0208
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0009 0.011
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0018 0.0208
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Onchocerca volvulus 0.0028 0.0036 0.0393
Onchocerca volvulus 0.0028 0.0036 0.0393
Plasmodium vivax phosphoglycerate kinase, putative 0.0204 0.0376 0.4448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.003 0.004 0.004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.004 0.0438
Plasmodium falciparum amino acid transporter, putative 0.003 0.004 0.0476
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0003 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0058 0.0113
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0063 0.0063
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0156 0.0283 0.0283
Brugia malayi Phosphoglycerate kinase 0.0075 0.0126 0.0126
Loa Loa (eye worm) solute carrier family 6 member 4 0.0179 0.0328 0.0325
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0003 0.0003
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0008 0.006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Schistosoma mansoni cytochrome P450 0.0014 0.0008 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0052 0.0102
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0003 0.0006
Schistosoma mansoni cpg binding protein 0.0067 0.0112 0.0112
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0446 0.0845 0.0845
Schistosoma mansoni neuropeptide receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0446 0.0845 0.0845
Schistosoma mansoni voltage-gated cation channel 0.0156 0.0283 0.0283
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.0126 0.0247
Echinococcus multilocularis voltage dependent calcium channel 0.0156 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0156 0.0156
Onchocerca volvulus Huntingtin homolog 0.0402 0.076 0.8991
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0258 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0063 0.1103
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Trypanosoma brucei histone deacetylase 3 0.0022 0.0024 0.0047
Leishmania major cathepsin L-like protease 0.0071 0.0119 0.0228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0009 0.011
Leishmania major glycerol uptake protein, putative 0.0446 0.0845 0.1651
Loa Loa (eye worm) serotonin transporter b 0.0179 0.0328 0.0325
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0054 0.0925
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0003
Brugia malayi histone deacetylase 3 (HD3) 0.0077 0.013 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0014 0.0014
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.004 0.004
Brugia malayi hypothetical protein 0.0071 0.0119 0.0119
Echinococcus granulosus voltage dependent calcium channel 0.0156 0.0283 0.0283
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0446 0.0845 0.0845
Loa Loa (eye worm) hypothetical protein 0.0446 0.0845 0.0842
Echinococcus multilocularis cysteine protease 0.0019 0.0018 0.0018
Schistosoma mansoni myosin xvIII 0.0028 0.0036 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0208
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0063 0.006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Trypanosoma brucei phosphoglycerate kinase 0.0204 0.0376 0.0737
Trichomonas vaginalis rotamase, putative 0.0037 0.0054 0.0635
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0063 0.0743
Loa Loa (eye worm) hypothetical protein 0.0031 0.0041 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0845 1
Brugia malayi Melatonin receptor type 1A 0.0028 0.0036 0.0036
Loa Loa (eye worm) MBOAT family protein 0.0446 0.0845 0.0842
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0025 0.0049
Schistosoma mansoni rab6-interacting 0.0042 0.0062 0.0062
Onchocerca volvulus Histone deacetylase 10 homolog 0.0022 0.0024 0.0248
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0179 0.0328 0.0325
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0003 0.0003
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0036 0.0036
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.0018
Brugia malayi Cytochrome P450 family protein 0.0023 0.0025 0.0025
Toxoplasma gondii histone deacetylase HDAC1 0.0022 0.0024 0.0243
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0446 0.0845 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0446 0.0845 0.0845
Schistosoma mansoni sodium/chloride dependent transporter 0.0179 0.0328 0.0328
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0446 0.0845 0.0845
Loa Loa (eye worm) MBOAT family protein 0.0446 0.0845 0.0842
Loa Loa (eye worm) hypothetical protein 0.0156 0.0283 0.028
Brugia malayi cathepsin L-like precursor 0.0013 0.0006 0.0006
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0126 0.0126
Trypanosoma cruzi GUP1, putative 0.0446 0.0845 0.1657
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.003 0.004 0.0438
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2646 0.5099 1
Onchocerca volvulus 0.0042 0.0063 0.0711
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0446 0.0845 0.0845
Brugia malayi Sodium:neurotransmitter symporter family protein 0.003 0.004 0.004
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0156 0.0283 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Schistosoma mansoni phosphoglycerate kinase 0.0204 0.0376 0.0376
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.003 0.004 0.004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.0472 0.0469
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0036 0.0036
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0036 0.0036
Schistosoma mansoni biogenic amine receptor 0.0028 0.0036 0.0036
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.007 0.0117 0.0117
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0446 0.0845 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0156 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0446 0.0845 0.0842
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0036 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0003
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0058 0.0058
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0058 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0298 0.0557 0.0555
Echinococcus multilocularis cysteine protease 0.0019 0.0018 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0105 0.0102
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0036 0.0036
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0036 0.0036
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hhat protein 0.0446 0.0845 0.0842
Brugia malayi ORL1-like opioid receptor 0.0028 0.0036 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0204 0.0376 0.0373
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.032 0.3794
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0062 0.0062
Loa Loa (eye worm) calcium channel 0.0156 0.0283 0.028
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0014 0.0014
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0446 0.0845 0.0845
Brugia malayi G-protein coupled receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0437 0.517
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0003 0.0003
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.0126 0.0247
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0036 0.0036
Leishmania major cytochrome p450-like protein 0.0014 0.0008 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0036 0.0036
Echinococcus granulosus serotonin transporter 0.0179 0.0328 0.0328
Schistosoma mansoni neuropeptide receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0208 0.0205
Plasmodium vivax hypothetical protein, conserved 0.003 0.004 0.0476
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.0911 0.0911
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.013 0.0255
Onchocerca volvulus 0.0028 0.0036 0.0393
Brugia malayi Histone deacetylase family protein 0.0022 0.0024 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0063 0.0743
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0036 0.0036
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0056 0.004
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0446 0.0845 0.0845
Entamoeba histolytica hypothetical protein 0.0446 0.0845 1
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0036 0.0033
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0028
Onchocerca volvulus 0.0028 0.0036 0.0393
Leishmania major glycerol uptake protein, putative 0.0446 0.0845 0.1651
Brugia malayi Histone deacetylase 1 0.0077 0.013 0.013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0054 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0028 0.0036 0.0036
Schistosoma mansoni rotamase 0.0037 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0036 0.0036
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0446 0.0845 0.0845
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0036 0.0036
Toxoplasma gondii histone deacetylase HDAC4 0.0022 0.0024 0.0243
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0036 0.0036
Echinococcus granulosus histone deacetylase 7 0.0022 0.0024 0.0024
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0006
Onchocerca volvulus 0.0019 0.0018 0.0174
Toxoplasma gondii histone deacetylase HDAC5 0.0022 0.0024 0.0243
Echinococcus granulosus phosphoglycerate kinase 1 0.0204 0.0376 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0156 0.0156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0003 0.0003
Trichomonas vaginalis esterase, putative 0.0042 0.0063 0.0743
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0054 0.136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0003 0.0003
Trypanosoma brucei glycerol uptake protein, putative 0.0446 0.0845 0.1657
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.004 0.004
Schistosoma mansoni phosphoglycerate kinase 0.0204 0.0376 0.0376
Onchocerca volvulus 0.0028 0.0036 0.0393
Schistosoma mansoni ap endonuclease 0.0038 0.0054 0.0054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0036 0.0036
Trypanosoma cruzi glycerol uptake protein, putative 0.0446 0.0845 0.1657
Loa Loa (eye worm) histone deacetylase 3 0.0077 0.013 0.0127
Schistosoma mansoni histone deacetylase 0.0077 0.013 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0042 0.0063 0.0711
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0041 0.0041
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1412
Schistosoma mansoni histone deacetylase 0.0077 0.013 0.013
Onchocerca volvulus 0.0235 0.0437 0.5154
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0003 0.0003
Echinococcus granulosus histone deacetylase 6 0.0022 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0071 0.0119 0.1412
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0008 0.0016
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0058 0.0058
Echinococcus granulosus dnaJ subfamily B 0.0451 0.0854 0.0854
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0543 0.1032 0.1029
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0036 0.0036
Echinococcus multilocularis voltage dependent calcium channel 0.0156 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0288 0.0538 0.0536
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0446 0.0845 0.0842
Echinococcus multilocularis histone deacetylase 6 0.0022 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0208
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0156 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.006
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Onchocerca volvulus 0.0028 0.0036 0.0393
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0036 0.0036
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0062 0.0737
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0062 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0119 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0063 0.0743
Loa Loa (eye worm) histone deacetylase 0.0022 0.0024 0.0021
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0033
Brugia malayi beta-lactamase family protein 0.0042 0.0063 0.0063
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0063 0.0742
Loa Loa (eye worm) hypothetical protein 0.1352 0.2597 0.2595
Loa Loa (eye worm) hhat protein 0.0446 0.0845 0.0842
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0036 0.0036
Schistosoma mansoni rab6-interacting 0.0042 0.0062 0.0062
Echinococcus multilocularis 0.0014 0.0008 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0003 0.0003
Loa Loa (eye worm) norepinephrine transporter 0.0179 0.0328 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0036 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0028 0.0036 0.0393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.054 0.6392
Plasmodium vivax histone deacetylase 2, putative 0.0022 0.0024 0.0281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0003 0.0003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.003 0.004 0.004
Onchocerca volvulus 0.0019 0.0018 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0303 0.3589
Echinococcus multilocularis muscleblind protein 1 0.0298 0.0557 0.0557
Toxoplasma gondii ABC1 family protein 0.0042 0.0063 0.0706
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0303 0.3567
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0063 0.1481
Entamoeba histolytica hypothetical protein, conserved 0.0446 0.0845 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0059
Brugia malayi Hhat protein 0.0446 0.0845 0.0845
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.041 0.041
Schistosoma mansoni hypothetical protein 0.007 0.0117 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0063 0.0743
Onchocerca volvulus Huntingtin homolog 0.0402 0.076 0.8991
Echinococcus multilocularis GPCR, family 2 0.007 0.0117 0.0117
Brugia malayi Cytochrome P450 family protein 0.0014 0.0008 0.0008
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.003 0.004 0.004
Toxoplasma gondii histone deacetylase HDAC2 0.0077 0.013 0.1506

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 155 nM Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assay ChEMBL. 21634430
IC50 (functional) = 0.98 uM Antiproliferative activity against human COLO205 cells after 96 hrs by celltiter 96 assay ChEMBL. 21634430

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21634430

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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