Detailed information for compound 1125588

Basic information

Technical information
  • TDR Targets ID: 1125588
  • Name: ChemDiv3_002286
  • MW: 302.368 | Formula: C17H22N2O3
  • H donors: 0 H acceptors: 3 LogP: 0.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CCC(=O)N2CCCCC2)C(=O)C2C1C1C=CC2C1
  • InChi: 1S/C17H22N2O3/c20-13(18-7-2-1-3-8-18)6-9-19-16(21)14-11-4-5-12(10-11)15(14)17(19)22/h4-5,11-12,14-15H,1-3,6-10H2
  • InChiKey: RDEGNBRMRGWRIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[3-oxo-3-(1-piperidinyl)propyl]-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3,5-dione
  • MLS000683280
  • SMR000267632
  • Oprea1_433926
  • Oprea1_460566
  • EU-0075801

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0013 0.0034 0.0081
Loa Loa (eye worm) inositol-1 0.0036 0.0198 0.0269
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0034 0.0849
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0013 0.0034 0.0033
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0047 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0253 0.0309
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0013 0.0034 0.0033
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.2002 0.2002
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0253 0.0957
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Onchocerca volvulus 0.0047 0.0278 0.3418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0253 0.0343
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0013 0.0034 0.0033
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0013 0.0034 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0034 0.0045
Trypanosoma brucei glucosidase, putative 0.0038 0.0212 0.8283
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7385 1
Schistosoma mansoni aldehyde dehydrogenase 0.0241 0.1688 0.2286
Schistosoma mansoni survival motor neuron protein 0.0047 0.0278 0.0377
Brugia malayi Fibroblast growth factor family protein 0.0058 0.0358 0.0485
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0034 0.0849
Echinococcus multilocularis dnaJ subfamily B 0.0864 0.622 0.622
Schistosoma mansoni ferritin light chain 0.0017 0.0058 0.0078
Echinococcus granulosus bloom syndrome protein 0.0024 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0034 0.0122
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0013 0.0034 0.0033
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0013 0.0034 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.1688 0.6674
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0198 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.1758 0.2381
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0013 0.0034 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0378 0.0512
Loa Loa (eye worm) hypothetical protein 0.0079 0.0513 0.0695
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.022 0.0297
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0198 0.0234
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0026 0.0035
Entamoeba histolytica hypothetical protein 0.0039 0.022 0.0263
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0253 0.0957
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0072 0.0097
Echinococcus multilocularis expressed protein 0.0017 0.0058 0.0058
Mycobacterium ulcerans hypothetical protein 0.0043 0.0253 0.0957
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0031 0.0732
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.004 0.1099
Schistosoma mansoni ferritin light chain 0.0017 0.0058 0.0078
Loa Loa (eye worm) cytochrome P450 0.001 0.0013 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0253 0.0957
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1182 0.1601
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0356 0.2523 0.3393
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0212 0.0253
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0076 0.2611
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.1758 0.2381
Echinococcus multilocularis lamin dm0 0.0026 0.0129 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Schistosoma mansoni hypothetical protein 0.0706 0.5067 0.6862
Schistosoma mansoni alpha-glucosidase 0.0147 0.1003 0.1358
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0253 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0034 0.001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0358 0.0485
Schistosoma mansoni hypothetical protein 0.0079 0.0513 0.0695
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0253 0.0309
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0212 0.0212
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0026 0.0035
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0212 0.0253
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.2002 0.2711
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0112 0.0117
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0037 0.0015
Schistosoma mansoni ferritin 0.0017 0.0058 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0046
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0026 0.0026
Onchocerca volvulus 0.0043 0.0253 0.3111
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0034 0.0849
Brugia malayi hypothetical protein 0.0012 0.0026 0.0035
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0026 0.0035
Mycobacterium tuberculosis Conserved protein 0.0043 0.0253 0.0957
Schistosoma mansoni intermediate filament proteins 0.0026 0.0129 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0112 0.0117
Onchocerca volvulus 0.0099 0.0654 0.803
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.004 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Onchocerca volvulus Huntingtin homolog 0.0121 0.0814 1
Echinococcus multilocularis GPCR, family 2 0.0079 0.0513 0.0513
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0253 0.0957
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0278 0.0377
Onchocerca volvulus Huntingtin homolog 0.0121 0.0814 1
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0034 0.0122
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0253 0.0343
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0212 0.0253
Schistosoma mansoni alpha-glucosidase 0.0147 0.1003 0.1358
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0076 0.025
Echinococcus granulosus geminin 0.0706 0.5067 0.5067
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0112 0.0112
Echinococcus granulosus dUTP pyrophosphatase 0.1025 0.7385 0.7385
Trichomonas vaginalis helicase, putative 0.0014 0.0037 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0129 0.0174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0198 0.0256
Schistosoma mansoni hypothetical protein 0.0171 0.1182 0.1601
Entamoeba histolytica hypothetical protein 0.0356 0.2523 0.3393
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0031 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0034 0.0081
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0013 0.0034 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2002 0.2711
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1956 0.7742
Schistosoma mansoni DNA helicase recq5 0.001 0.001 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0253 0.0309
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0058 0.0033
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0076 0.0103
Brugia malayi beta-lactamase 0.0043 0.0253 0.0343
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0034 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.1384 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0513 0.0513
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.2002 0.2711
Schistosoma mansoni lamin 0.0026 0.0129 0.0174
Brugia malayi Cytochrome P450 family protein 0.0019 0.0076 0.0103
Schistosoma mansoni hypothetical protein 0.0013 0.0034 0.0045
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0026 0.0035
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0013 0.0034 0.0081
Entamoeba histolytica hypothetical protein 0.1025 0.7385 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0031 0.0732
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.7713
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0013 0.0034 0.0045
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0026 0.0035
Leishmania major hypothetical protein, conserved 0.0043 0.0253 0.1433
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.1688 0.6674
Entamoeba histolytica hypothetical protein 0.0039 0.022 0.0263
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0034 0.0122
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0013 0.0034 0.0045
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.001 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0513 0.0695
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.004 0.0054
Onchocerca volvulus 0.0043 0.0253 0.3111
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0253 0.0253
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0212 0.0253
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0013 0.0034 0.0081
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0356 0.2523 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0026 0.0035
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0356 0.2523 1
Schistosoma mansoni hypothetical protein 0.0039 0.022 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0253 0.0309
Schistosoma mansoni inositol monophosphatase 0.0036 0.0198 0.0268
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1633 0.2211
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0034 0.0849
Brugia malayi Aldehyde dehydrogenase protein 4 0.0013 0.0034 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0212 0.0253
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0198 0.0738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0026 0.0026
Onchocerca volvulus 0.0012 0.0026 0.0317
Brugia malayi beta-lactamase family protein 0.0043 0.0253 0.0343
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0253 0.0957
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0054 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.004 0.0019
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0026 0.0026
Brugia malayi Cytochrome P450 family protein 0.0019 0.0076 0.0103
Leishmania major cytochrome p450-like protein 0.0019 0.0076 0.0374
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0026 0.0035
Entamoeba histolytica hypothetical protein 0.0669 0.4799 0.6486
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0356 0.2523 1
Echinococcus multilocularis 0.001 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0074 0.0074
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0513 0.0513
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0026 0.0035
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0013 0.0034 0.0081
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.001 0.00000000004463
Trichomonas vaginalis esterase, putative 0.0043 0.0253 0.0309
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0034 0.0849
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0013 0.0034 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0129 0.0174
Loa Loa (eye worm) RecQ helicase 0.0024 0.0112 0.0152
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.004 0.0054
Brugia malayi cytochrome P450 0.001 0.0013 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0253 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0198 0.0234
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0286 0.0388
Mycobacterium tuberculosis Conserved protein 0.0043 0.0253 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0253 0.0343
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.004 0.0019
Brugia malayi Fibroblast growth factor family protein 0.0058 0.0358 0.0485
Onchocerca volvulus 0.0043 0.0253 0.3111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0013 0.0034 0.0081
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0058 0.0178
Trichomonas vaginalis ferritin, putative 0.0017 0.0058 0.0043
Echinococcus multilocularis dUTP pyrophosphatase 0.1025 0.7385 0.7385
Schistosoma mansoni cpg binding protein 0.0064 0.0404 0.0546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.022 0.0219
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0013 0.0034 0.0081
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0026 0.0026
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0076 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0013 0.0034 0.0081
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0034 0.001
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1176 0.1176
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0129 0.0174
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0013 0.0034 0.0081
Schistosoma mansoni hypothetical protein 0.0079 0.0513 0.0695
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0253 1
Echinococcus multilocularis ferritin 0.0017 0.0058 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0034 0.0045
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.1106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.2002 0.2002
Entamoeba histolytica hypothetical protein 0.0669 0.4799 0.6486
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Echinococcus multilocularis expressed protein 0.0012 0.0026 0.0026
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0047 0.0047
Echinococcus granulosus expressed protein 0.0012 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0039 0.022 0.0263
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.1176 0.1592
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0013 0.0034 0.0033
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0058 0.0178
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0026 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1633 0.2211
Echinococcus multilocularis neuropeptide s receptor 0.1384 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.004 0.0019
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.1176 0.1592
Echinococcus granulosus dnaJ subfamily B 0.0864 0.622 0.622
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0058 0.0033
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0212 0.0253
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0013 0.0034 0.0081
Schistosoma mansoni cytochrome P450 0.001 0.0013 0.0018
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0013 0.0034 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.001 0.0009
Leishmania major glycosyl hydrolase-like protein 0.0014 0.004 0.0158
Brugia malayi intermediate filament protein 0.0026 0.0129 0.0174
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0034 0.0849
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.7713
Echinococcus granulosus intermediate filament protein 0.0026 0.0129 0.0128
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0034 0.0033
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0356 0.2523 1
Echinococcus granulosus lamin dm0 0.0026 0.0129 0.0128
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0026 0.0035
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0034 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0253 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.022 0.0219
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0212 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.0241 0.1688 0.2286
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.004 0.0485
Echinococcus multilocularis lamin 0.0026 0.0129 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0241 0.1688 0.6674
Brugia malayi aldehyde dehydrogenase 0.0013 0.0034 0.0045
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0013 0.0034 0.0033
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.001 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0253 0.0957
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0171 0.0629
Loa Loa (eye worm) hypothetical protein 0.0026 0.0129 0.0174
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7385 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0253 0.0957
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0855 0.1158
Echinococcus granulosus expressed protein 0.0017 0.0058 0.0058
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1609 0.1609
Brugia malayi Cytochrome P450 family protein 0.001 0.0013 0.0018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.1758 0.2381
Brugia malayi dUTP diphosphatase 0.1025 0.7385 1
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0013 0.0013
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.1025 0.7385 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0198 0.0234
Schistosoma mansoni apoferritin-2 0.0017 0.0058 0.0078
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0013 0.0034 0.0033
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0034 0.0081
Giardia lamblia Hypothetical protein 0.0058 0.0358 1
Schistosoma mansoni cpg binding protein 0.0061 0.0378 0.0512
Toxoplasma gondii aldehyde dehydrogenase 0.0241 0.1688 0.2276
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0356 0.2523 0.3393
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0013 0.0034 0.0081
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0031 0.0105
Brugia malayi beta-lactamase family protein 0.0043 0.0253 0.0343
Brugia malayi Cytochrome P450 family protein 0.0048 0.0286 0.0387
Schistosoma mansoni ferritin 0.0017 0.0058 0.0078
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7385 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0047 0.0063
Brugia malayi hypothetical protein 0.0039 0.022 0.0297
Schistosoma mansoni inositol monophosphatase 0.0036 0.0198 0.0268
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0013 0.0034 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.004 0.0019
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.001 0.0013
Brugia malayi hypothetical protein 0.0121 0.0814 0.1102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.004 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0046
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0013 0.0034 0.0045
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0026 0.0026
Brugia malayi Inositol-1 0.0036 0.0198 0.0268
Echinococcus granulosus cpg binding protein 0.0064 0.0404 0.0403
Loa Loa (eye worm) hypothetical protein 0.0121 0.0814 0.1102
Loa Loa (eye worm) hypothetical protein 0.0058 0.0358 0.0485
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0026 0.0026
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0013 0.0034 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0253 1
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0513 0.0695
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Schistosoma mansoni hypothetical protein 0.0079 0.0513 0.0695
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0212 0.8283
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0013 0.0034 0.0081
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0198 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0253 0.027
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0013 0.0034 0.0849
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0212 0.0287
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7385 1
Schistosoma mansoni cpg binding protein 0.0064 0.0404 0.0546
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7385 1
Brugia malayi hypothetical protein 0.023 0.1609 0.2179
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0773 0.1035
Leishmania major aldehyde dehydrogenase, putative 0.0013 0.0034 0.0122
Schistosoma mansoni microtubule-associated protein tau 0.0713 0.5121 0.6934
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0058 0.0178
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0013 0.0034 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0037 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0212 0.8283
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0212 0.0253
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7385 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0013 0.0005
Schistosoma mansoni hypothetical protein 0.0079 0.0513 0.0695
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0026 0.0035
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0026 0.0035
Onchocerca volvulus 0.0012 0.0026 0.0317
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0034 0.0045
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0026 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0241 0.1688 0.1688
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0013 0.0034 0.0081
Loa Loa (eye worm) aldehyde dehydrogenase 0.0013 0.0034 0.0046
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0198 0.0198
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0074 0.01
Loa Loa (eye worm) dUTP diphosphatase 0.1025 0.7385 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0253 0.0309
Mycobacterium ulcerans lipase LipD 0.0043 0.0253 0.0957
Echinococcus granulosus lamin 0.0026 0.0129 0.0128
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0198 0.0198
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.004 0.0019
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0013 0.0034 0.0081
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.004 0.1099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0253 0.0343
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0026 0.0035
Wolbachia endosymbiont of Brugia malayi dUTPase 0.1025 0.7385 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0035
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0026 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0076 0.2611
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0013 0.0034 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0241 0.1688 0.1688
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0513 0.0513
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0076 0.0103
Loa Loa (eye worm) hypothetical protein 0.0121 0.0819 0.1109
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0026 0.0035
Giardia lamblia Alcohol dehydrogenase 0.0013 0.0034 0.0691
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.004 0.0019
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1025 0.7385 1
Schistosoma mansoni hypothetical protein 0.0047 0.0278 0.0377
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0212 0.0253
Echinococcus multilocularis cpg binding protein 0.0064 0.0404 0.0403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0513 0.0695
Loa Loa (eye worm) hypothetical protein 0.0043 0.0253 0.0343
Loa Loa (eye worm) beta-lactamase 0.0043 0.0253 0.0343
Echinococcus granulosus ferritin 0.0017 0.0058 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0013 0.0034 0.0045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0037 0.0015
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0058 0.0178
Loa Loa (eye worm) hypothetical protein 0.023 0.1609 0.2179
Loa Loa (eye worm) hypothetical protein 0.0171 0.1182 0.1601
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.003 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.1384 1 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0026 0.0035
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0013 0.0034 0.0849
Loa Loa (eye worm) hypothetical protein 0.0121 0.0814 0.1102
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0013 0.0034 0.0081
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0855 0.1158
Onchocerca volvulus 0.0026 0.0129 0.1579
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7385 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.004 0.0019
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1176 0.1176
Loa Loa (eye worm) hypothetical protein 0.0251 0.1758 0.2381
Echinococcus multilocularis geminin 0.0706 0.5067 0.5067
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.1025 0.7385 1
Brugia malayi G-protein alpha subunit 0.0012 0.0026 0.0035
Toxoplasma gondii ABC1 family protein 0.0043 0.0253 0.0331
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0026 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0873 0.1182
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1025 0.7385 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0026 0.0035
Mycobacterium tuberculosis Conserved protein 0.0043 0.0253 0.0957
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0212 0.0253
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0013 0.0034 0.0081
Schistosoma mansoni hypothetical protein 0.0706 0.5067 0.6862
Schistosoma mansoni ferritin 0.0017 0.0058 0.0078
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0013 0.0034 0.0045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0198 0.7713
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0091 0.0111
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0026 0.0035
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0013 0.0034 0.0033
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0356 0.2523 0.3386
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0026 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0026 0.0035
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0013 0.0034 0.0081
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0013 0.0034 0.0081
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0031 0.0007
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0013 0.0034 0.0033
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.001 0.0013
Schistosoma mansoni lamin 0.0026 0.0129 0.0174
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.004 0.1099
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0013
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0026 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.004 0.0053
Echinococcus granulosus GPCR family 2 0.0079 0.0513 0.0513
Onchocerca volvulus 0.0012 0.0026 0.0317
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0212 0.0253
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.001 0.0013
Mycobacterium leprae Probable lipase LipE 0.0043 0.0253 0.0957
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.1025 0.7385 1
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0013 0.0034 0.0081
Echinococcus multilocularis musashi 0.0026 0.0129 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0037 0.0015
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0026 0.0035
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.1025 0.7385 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0026 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.0713 0.5121 0.5121
Schistosoma mansoni hypothetical protein 0.0864 0.622 0.8423
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0513 0.0513
Schistosoma mansoni apoferritin-2 0.0017 0.0058 0.0078
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0253 0.0957
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0058 0.0178
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.1176 0.1176
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0171 0.0629
Entamoeba histolytica hypothetical protein 0.0039 0.022 0.0263
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0013 0.0034 0.0081
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0013 0.0034 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0241 0.1688 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2002 0.2711
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.001 0.0009
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0026 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.004
Onchocerca volvulus 0.0061 0.0378 0.4648
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0013 0.0034 0.0081
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0076 0.2611
Schistosoma mansoni ferritin 0.0017 0.0058 0.0078
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0013 0.0034 0.0081
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.5739 0.5739
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0026 0.0035
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0026 0.0035
Schistosoma mansoni DNA helicase recq1 0.001 0.001 0.0013
Brugia malayi MH2 domain containing protein 0.0126 0.0855 0.1157
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0013 0.0034 0.0849
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0013 0.0034 0.0849
Schistosoma mansoni hypothetical protein 0.001 0.0013 0.0018
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0112 0.0152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.2002 0.2002
Echinococcus granulosus microtubule associated protein 2 0.0713 0.5121 0.5121
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0047 0.0047
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0212 0.0253
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0212 0.0287
Onchocerca volvulus 0.0026 0.0129 0.1579
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0074 0.0074
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0212 0.1187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0253 0.0957
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.1025 0.7385 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0212 0.0287
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0013 0.0034 0.0411
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.2002 0.2002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0253 0.0957
Mycobacterium ulcerans aldehyde dehydrogenase 0.0241 0.1688 0.6674
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.2002 0.2711
Brugia malayi CXXC zinc finger family protein 0.0061 0.0378 0.0512
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0013 0.0034 0.0849
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1609 0.1609

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 501.1872 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.