Detailed information for compound 1177144

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 275.282 | Formula: C13H14FN5O
  • H donors: 3 H acceptors: 3 LogP: 0.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCC[C@@H]1CNC(=O)c2c1[nH]c(c2)c1ccnc(n1)N
  • InChi: 1S/C13H14FN5O/c14-3-1-7-6-17-12(20)8-5-10(18-11(7)8)9-2-4-16-13(15)19-9/h2,4-5,7,18H,1,3,6H2,(H,17,20)(H2,15,16,19)/t7-/m1/s1
  • InChiKey: LCBAQTCTQXHTJG-SSDOTTSWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 9 Starlite/ChEMBL References
Homo sapiens cell division cycle 7 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans CDC2-related protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Candida albicans similar ot C terminus of S. cerevisiae SGV1 (YPR161C) Get druggable targets OG5_130531 All targets in OG5_130531
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Brugia malayi cyclin-dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni kinase Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 9 372 aa 313 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0099 0.0967 0.1445
Echinococcus multilocularis GPCR, family 2 0.006 0.0486 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.001
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0236 0.0742
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.0152 0.0864
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0131
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Loa Loa (eye worm) hypothetical protein 0.025 0.281 0.4206
Brugia malayi SRC-1 0.0029 0.011 0.0162
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Schistosoma mansoni kinase 0.0068 0.059 0.0665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0108 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.004 0.024 0.027
Schistosoma mansoni protein kinase 0.0203 0.2234 0.2524
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Echinococcus multilocularis Niemann Pick C1 protein 0.03 0.3422 0.3422
Leishmania major protein kinase, putative 0.0024 0.0046 0.0254
Echinococcus multilocularis MAM 0.0034 0.0168 0.0168
Brugia malayi map kinase activated protein kinase protein 2 0.0228 0.2539 0.3798
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0068 0.0588 0.0665
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Brugia malayi Latrophilin receptor protein 2 0.006 0.0486 0.0725
Entamoeba histolytica protein kinase, putative 0.0034 0.0163 0.044
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0116
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0133 0.1384 0.2071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0087 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.3414
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0086 0.0801 0.4601
Schistosoma mansoni tyrosine kinase 0.0262 0.296 0.3345
Onchocerca volvulus 0.005 0.0361 0.0531
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Echinococcus granulosus cyclin dependent kinase 9 0.0065 0.0548 0.062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0124 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0008 0.0008
Echinococcus granulosus tumor protein p63 0.0317 0.3628 0.4102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0303
Giardia lamblia Fructose-bisphosphate aldolase 0.0321 0.3682 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1583 0.2367
Brugia malayi serine/threonine-protein kinase 6 0.0078 0.0712 0.1063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0144 0.151 0.8683
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0854 0.0964
Brugia malayi serine/threonine kinase 12 0.0078 0.0712 0.1063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0072 0.0192
Brugia malayi intracellular kinase 0.0068 0.0588 0.0878
Loa Loa (eye worm) hypothetical protein 0.0071 0.0621 0.093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Brugia malayi plexin A 0.0025 0.0054 0.0078
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0068 0.0588 0.0664
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0072 0.0631 0.3625
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Echinococcus granulosus plexin a4 0.0025 0.0054 0.0061
Echinococcus multilocularis Niemann Pick C1 protein 0.021 0.232 0.232
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0164 0.0235
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Entamoeba histolytica protein kinase, putative 0.0068 0.0588 0.1594
Brugia malayi ecdysteroid receptor 0.0021 0.0008 0.001
Echinococcus granulosus cyclin dependent kinase 0.0114 0.1146 0.1296
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0008 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Giardia lamblia Kinase, CMGC MAPK 0.0072 0.0631 0.1711
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0283 0.1619
Onchocerca volvulus 0.004 0.0236 0.0343
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0163 0.0244
Schistosoma mansoni coup transcription factor 0.0021 0.0008 0.0008
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.1672 0.5837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0108 0.072
Onchocerca volvulus 0.0021 0.0012 0.0008
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0212 0.2351 0.3518
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0021 0.0012 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Giardia lamblia Kinase, PLK 0.0125 0.1276 0.3463
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0001 0.0002
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Echinococcus multilocularis protein kinase shaggy 0.0068 0.0588 0.0588
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Schistosoma mansoni serine/threonine protein kinase 0.0228 0.2539 0.2869
Brugia malayi cell division control protein 2 homolog 0.0114 0.1146 0.1714
Echinococcus granulosus mitogen activated protein kinase 3 0.0072 0.0631 0.0714
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0162 0.1739 1
Entamoeba histolytica protein kinase , putative 0.0078 0.0712 0.193
Brugia malayi kinase, mitochondrial precursor 0.0144 0.151 0.2258
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0259 0.2918 0.4367
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0027 0.0076 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0008 0.0008
Echinococcus granulosus lamin 0.0057 0.0447 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0002 0.0000097908
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0452 0.3262
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0068 0.0588 0.5014
Echinococcus granulosus insulin receptor 0.017 0.1831 0.207
Brugia malayi intermediate filament protein 0.0057 0.0447 0.0667
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0008 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0012
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0114 0.1146 0.1714
Plasmodium falciparum glycogen synthase kinase 3 0.0068 0.0588 0.4246
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0163 0.0244
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Echinococcus multilocularis tyrosine protein kinase Blk 0.0021 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0103 0.1011 0.5808
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0029 0.011 0.011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0009
Toxoplasma gondii non-specific serine/threonine protein kinase 0.003 0.0113 0.0768
Echinococcus multilocularis cyclin dependent kinase 5 0.0114 0.1146 0.1146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus tyrosine protein kinase Srms 0.0021 0.0012 0.0014
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus granulosus Niemann Pick C1 protein 0.03 0.3422 0.3869
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0008 0.001
Echinococcus granulosus lamin dm0 0.0057 0.0447 0.0505
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0236 0.0742
Echinococcus multilocularis protein dispatched 1 0.0103 0.101 0.101
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0042 0.0262 0.0295
Brugia malayi hypothetical protein 0.0244 0.274 0.41
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0114 0.1146 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0021 0.0012 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2232 0.3341
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus multilocularis raf serine:threonine protein kinase 0.002 0.0002 0.0002
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0008 0.0008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0008
Echinococcus granulosus protein kinase c iota type 0.0041 0.0253 0.0286
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0027 0.0038
Trypanosoma brucei aurora B kinase 0.0078 0.0712 0.4089
Echinococcus granulosus cyclin dependent kinase 1 0.0114 0.1146 0.1296
Brugia malayi Niemann-Pick C1 protein precursor 0.021 0.232 0.3471
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.274 0.274
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.011 0.0124
Echinococcus granulosus activin receptor type 0.0024 0.0046 0.0051
Loa Loa (eye worm) hypothetical protein 0.021 0.232 0.3472
Onchocerca volvulus 0.0046 0.0319 0.0468
Brugia malayi Protein kinase domain containing protein 0.0212 0.2351 0.3516
Echinococcus multilocularis plexin a4 0.0025 0.0054 0.0054
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0026 0.0076 0.0076
Echinococcus granulosus low density lipoprotein receptor ldl 0.0027 0.0076 0.0086
Echinococcus granulosus c src tyrosine kinase 0.0029 0.011 0.0124
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0024 0.0046 0.0051
Schistosoma mansoni titin 0.0038 0.022 0.0247
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Onchocerca volvulus 0.0141 0.1478 0.2204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0586 0.1589
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Echinococcus multilocularis serine:threonine protein kinase NLK 0.002 0.0001 0.0001
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0238 0.2666 0.2666
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Giardia lamblia Kinase, CMGC CDK 0.0114 0.1146 0.3111
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Trichomonas vaginalis STE family protein kinase 0.0133 0.1384 0.3755
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.021 0.232 0.6299
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0238 0.2666 0.3013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.2071 0.3097
Loa Loa (eye worm) glutaminase 0.0255 0.2874 0.4302
Entamoeba histolytica cell division protein kinase 2, putative 0.0114 0.1146 0.3111
Loa Loa (eye worm) TK/ABL protein kinase 0.027 0.306 0.4579
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0777 0.0777
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0008 0.0012
Schistosoma mansoni kinase 0.0065 0.0548 0.0618
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0565 0.6664 0.7534
Entamoeba histolytica protein kinase, putative 0.0058 0.0466 0.1262
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Loa Loa (eye worm) beta-lactamase 0.004 0.0236 0.0353
Echinococcus granulosus Niemann Pick C1 protein 0.021 0.232 0.2623
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0447 0.0667
Echinococcus multilocularis Immunoglobulin 0.0033 0.0153 0.0153
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0188 0.1074
Trypanosoma brucei developmentally regulated phosphoprotein 0.0144 0.151 0.8683
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0236 0.0742
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0033 0.0153 0.0153
Onchocerca volvulus 0.0231 0.2575 0.3847
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0078 0.0712 0.0805
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0243 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0103 0.1011 0.2741
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0212 0.235 0.235
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.1337 0.1999
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.005 0.0367 0.3032
Trichomonas vaginalis esterase, putative 0.004 0.0236 0.0638
Giardia lamblia Kinase, CDC7 0.0079 0.072 0.1952
Mycobacterium ulcerans lipase LipD 0.004 0.0236 0.0734
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0114 0.1146 0.1296
Echinococcus multilocularis tyrosine protein kinase Abl 0.0125 0.1275 0.1275
Schistosoma mansoni transcription factor LCR-F1 0.0067 0.0576 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0012
Brugia malayi nuclear hormone receptor 0.0021 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.017 0.1831 0.1831
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Echinococcus granulosus RNA directed DNA polymerase 0.0048 0.0335 0.0378
Leishmania major phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0689 0.2349
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0008
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Plasmodium vivax hypothetical protein, conserved 0.004 0.0236 0.1698
Schistosoma mansoni serine/threonine protein kinase 0.0125 0.1276 0.1441
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0262 0.0708
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0103 0.1011 0.1011
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0452 0.3262
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0368 0.0551
Brugia malayi Serine/threonine-protein kinase SULU 0.0238 0.2666 0.3988
Echinococcus multilocularis lamin dm0 0.0057 0.0447 0.0447
Leishmania major developmentally regulated phosphoprotein-like protein 0.0144 0.151 0.8683
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0008
Schistosoma mansoni survival motor neuron protein 0.005 0.0361 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0271 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0018
Echinococcus granulosus roundabout 2 0.0045 0.0297 0.0335
Trypanosoma cruzi cdc2-related kinase 1 0.0114 0.1146 0.659
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.1275 0.1907
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0103 0.1011 0.5808
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0024 0.0046 0.0046
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0038 0.022 0.0319
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.003 0.0116 0.0131
Brugia malayi SH2 domain containing protein 0.0021 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus granulosus GPCR family 2 0.006 0.0486 0.0549
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Loa Loa (eye worm) hypothetical protein 0.0046 0.0319 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Onchocerca volvulus 0.0079 0.072 0.1068
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0059 0.0473 0.0706
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0486
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0024 0.0046 0.0164
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0036 0.0188 0.135
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.006 0.0486 0.0728
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Brugia malayi hypothetical protein 0.0031 0.0132 0.0196
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.034 0.034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0689 0.2325
Loa Loa (eye worm) hypothetical protein 0.019 0.2071 0.3099
Echinococcus granulosus serine threonine protein kinase 0.0133 0.1384 0.1564
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.1634 0.2444
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Echinococcus granulosus expressed conserved protein 0.0197 0.2164 0.2447
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0059 0.0473 0.2716
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0447 0.0669
Trichomonas vaginalis glutaminase, putative 0.0255 0.2874 0.7805
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0125 0.1276 0.1276
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0486
Giardia lamblia Kinase, STE STE20 0.003 0.0116 0.031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0244
Brugia malayi protein kinase C II. 0.0042 0.0271 0.0404
Echinococcus multilocularis roundabout 2 0.0045 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1369
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0059 0.0473 0.2716
Echinococcus granulosus hemicentin 1 0.0038 0.022 0.0249
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0236 0.1351
Onchocerca volvulus 0.011 0.1097 0.1632
Brugia malayi hypothetical protein 0.0141 0.1478 0.221
Trypanosoma brucei cdc2-related kinase 1 0.0114 0.1146 0.659
Loa Loa (eye worm) hypothetical protein 0.0029 0.0108 0.0161
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0536 0.1453
Schistosoma mansoni nephrin 0.004 0.0241 0.027
Onchocerca volvulus 0.004 0.0236 0.0343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0079 0.072 0.1075
Echinococcus multilocularis insulin receptor 0.017 0.1831 0.1831
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Loa Loa (eye worm) SRC-1 0.0029 0.011 0.0165
Echinococcus multilocularis 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0029 0.0108 0.0151
Onchocerca volvulus 0.0027 0.0076 0.0104
Echinococcus granulosus geminin 0.0743 0.8846 1
Brugia malayi Protein kinase c protein 2 0.0067 0.0576 0.086
Onchocerca volvulus 0.0034 0.0164 0.0235
Schistosoma mansoni fkbp-rapamycin associated protein 0.0026 0.0076 0.0084
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.0124
Entamoeba histolytica protein kinase, putative 0.003 0.0116 0.031
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0029 0.011 0.011
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Brugia malayi Protein kinase domain containing protein 0.0203 0.2234 0.3342
Loa Loa (eye worm) hypothetical protein 0.0103 0.1013 0.1516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Brugia malayi Immunoglobulin I-set domain containing protein 0.0259 0.2918 0.4366
Echinococcus granulosus mitogen activated protein kinase 11 0.0162 0.1739 0.1966
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0588 0.1594
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Loa Loa (eye worm) plexin A 0.0025 0.0054 0.0081
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0029 0.011 0.011
Leishmania major protein kinase A catalytic subunit 0.0059 0.0473 0.2716
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0072 0.0631 0.3625
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0588 0.1594
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Trypanosoma cruzi cdc2-related kinase 3 0.0114 0.1146 0.659
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0133 0.1384 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0132 0.1369 0.1547
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0452 0.1493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0153 0.0227
Schistosoma mansoni pyruvate dehydrogenase 0.0144 0.151 0.1706
Brugia malayi hypothetical protein 0.0148 0.1562 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0486 0.0725
Onchocerca volvulus 0.0027 0.008 0.0109
Brugia malayi nuclear receptor NHR-88 0.0021 0.0008 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0236 0.0353
Plasmodium falciparum protein kinase, putative 0.0024 0.0046 0.0319
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0021 0.0012 0.0014
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Plasmodium vivax SET domain protein, putative 0.0029 0.0108 0.0769
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0163 0.0244
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0038 0.0218 0.1248
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0664 0.0751
Echinococcus granulosus serine:threonine protein kinase NLK 0.002 0.0001 0.0002
Echinococcus granulosus tyrosine kinase 0.0021 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0854 0.2316
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Echinococcus multilocularis CDC7 cell division cycle 7 0.0079 0.072 0.072
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0163 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Brugia malayi p70 ribosomal S6 kinase beta 0.0058 0.0466 0.0696
Loa Loa (eye worm) AGC/PKA protein kinase 0.0059 0.0473 0.0708
Echinococcus multilocularis cyclin dependent kinase 9 0.0065 0.0548 0.0548
Onchocerca volvulus 0.0021 0.0012 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Entamoeba histolytica protein kinase, putative 0.0133 0.1384 0.3755
Entamoeba histolytica protein kinase domain containing protein 0.0024 0.0046 0.012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0447 0.0669
Echinococcus multilocularis serine protein kinase ATM 0.0042 0.0262 0.0262
Echinococcus multilocularis expressed conserved protein 0.0197 0.2164 0.2164
Echinococcus granulosus fibroblast growth factor receptor 4 0.0132 0.1369 0.1547
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0009
Echinococcus granulosus serine:threonine protein kinase NIM1 0.011 0.1097 0.124
Echinococcus multilocularis protein patched 0.009 0.0854 0.0854
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0021 0.0012 0.0014
Schistosoma mansoni serine/threonine kinase 0.0034 0.0163 0.0183
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0068 0.0588 0.088
Echinococcus multilocularis cyclin dependent kinase 0.0114 0.1146 0.1146
Brugia malayi hypothetical protein 0.0034 0.0168 0.025
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.0727
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0321 0.3682 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0297 0.3387 0.5069
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0041
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0048 0.0335 0.0335
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0124 0.0184
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0689 0.1868
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.2577 0.3857
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Loa Loa (eye worm) hypothetical protein 0.009 0.0854 0.1278
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0008 0.0002
Brugia malayi serine/threonine-protein kinase PAK 7 0.0231 0.258 0.386
Brugia malayi Protein kinase domain containing protein 0.017 0.1831 0.2739
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0228 0.2539 0.287
Schistosoma mansoni cell adhesion molecule 0.0037 0.0209 0.0235
Brugia malayi glutaminase DH11.1 0.0255 0.2874 0.4301
Loa Loa (eye worm) hypothetical protein 0.0141 0.1478 0.2212
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Echinococcus granulosus protein kinase c epsilon type 0.0042 0.0271 0.0306
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0036 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0059 0.0473 0.0708
Loa Loa (eye worm) hypothetical protein 0.0309 0.3533 0.5287
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0029 0.011 0.0124
Brugia malayi steroid hormone receptor 0.0021 0.0008 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1097 0.1238
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0008 0.001
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0027 0.0031
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0712 0.193
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0279 0.0755
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Entamoeba histolytica protein kinase 2, putative 0.0036 0.0188 0.0507
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0068 0.0588 0.3378
Loa Loa (eye worm) phosphatidylinositol 3 0.0103 0.1011 0.1512
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0163 0.0163
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0144 0.151 0.1707
Echinococcus granulosus Protein patched homolog 1 0.009 0.0854 0.0965
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.1384 0.1563
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Schistosoma mansoni plexin 0.0021 0.0007 0.0006
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Echinococcus granulosus protein kinase C gamma type 0.0083 0.0764 0.0864
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0103 0.1011 0.5808
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0486 0.0727
Brugia malayi Fibronectin type III domain containing protein 0.0033 0.0153 0.0227
Echinococcus multilocularis tyrosine protein kinase ABL1 0.027 0.306 0.306
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0452 0.1509
Schistosoma mansoni hypothetical protein 0.013 0.1337 0.151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0056 0.0434 0.065
Brugia malayi hypothetical protein 0.0021 0.0012 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Echinococcus granulosus Protein kinase C brain isozyme 0.009 0.0854 0.0965
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Echinococcus granulosus raf serine:threonine protein kinase 0.002 0.0002 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0072 0.0631 0.3625
Toxoplasma gondii AGC kinase 0.0058 0.0466 0.3922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Schistosoma mansoni tyrosine kinase 0.0025 0.0056 0.0062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0103 0.1011 0.5808
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0125 0.1276 0.1443
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2575 0.6991
Schistosoma mansoni atypical protein kinase C 0.0041 0.0253 0.0284
Echinococcus multilocularis serine threonine protein kinase 0.0083 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.2351 0.2656
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0236 0.0267
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3533 0.3533
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Brugia malayi Cytochrome P450 family protein 0.005 0.0368 0.0549
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0236 0.0351
Loa Loa (eye worm) hypothetical protein 0.0048 0.0335 0.0501
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0065 0.0548 0.082
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Plasmodium falciparum serine/threonine protein kinase, putative 0.0078 0.0712 0.5139
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0236 0.0236
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.011 0.011
Echinococcus multilocularis aurora kinase A 0.0078 0.0712 0.0712
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0103 0.1011 0.1141
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.011 0.1097 0.1641
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Onchocerca volvulus 0.0566 0.6682 1
Echinococcus granulosus protein kinase shaggy 0.0068 0.0588 0.0665
Echinococcus multilocularis protein kinase c epsilon type 0.0042 0.0271 0.0271
Echinococcus multilocularis serine threonine protein kinase 0.0133 0.1384 0.1384
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0689 0.3959
Brugia malayi MAP kinase sur-1 0.0072 0.0631 0.0943
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Onchocerca volvulus 0.0021 0.0008 0.0002
Onchocerca volvulus 0.0077 0.0689 0.1022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0008 0.0002
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus multilocularis cyclin dependent kinase 1 0.0114 0.1146 0.1146
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.1672 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0027 0.0027
Trypanosoma brucei protein kinase, putative 0.0024 0.0046 0.0254
Brugia malayi hypothetical protein 0.0238 0.2666 0.3988
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Brugia malayi Protein kinase domain containing protein 0.0034 0.0163 0.0242
Brugia malayi Protein kinase domain containing protein 0.0297 0.3388 0.507
Schistosoma mansoni hypothetical protein 0.002 0.0003 0.0001
Echinococcus multilocularis mitogen activated protein kinase 3 0.0072 0.0631 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.001
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0023 0.003 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0236 0.0734
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Loa Loa (eye worm) oxidoreductase 0.0022 0.0027 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.059 0.16
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Schistosoma mansoni hypothetical protein 0.0034 0.0164 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1146 0.1295
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0029 0.011 0.011
Echinococcus granulosus contactin 0.0038 0.022 0.0249
Brugia malayi Pre-SET motif family protein 0.0203 0.2232 0.3339
Entamoeba histolytica protein kinase rad3, putative 0.0026 0.0076 0.0203
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0078 0.0712 0.5139
Trypanosoma cruzi aurora B kinase, putative 0.0078 0.0712 0.4089
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0125 0.1276 0.191
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0238 0.2666 0.3989
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0067 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.013 0.1337 0.2001
Onchocerca volvulus 0.0079 0.072 0.1068
Brugia malayi Protein kinase domain 0.003 0.0116 0.0171
Brugia malayi protein-tyrosine kinase 0.0021 0.0012 0.0016
Mycobacterium leprae Probable lipase LipE 0.004 0.0236 0.1271
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0027 0.0029
Onchocerca volvulus 0.0208 0.2301 0.3436
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.003 0.0116 0.0116
Echinococcus granulosus cyclin dependent kinase 5 0.0114 0.1146 0.1296
Echinococcus multilocularis hemicentin 1 0.0038 0.022 0.022
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Echinococcus multilocularis neuroglian 0.004 0.0241 0.0241
Brugia malayi Serine/threonine-protein kinase Nek7 0.026 0.293 0.4384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0504 0.1364
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0068 0.0588 0.0588
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0026 0.0076 0.0086
Giardia lamblia Kinase, AGC PKA 0.0036 0.0188 0.0507
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0185
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.068 0.8068 0.9121
Echinococcus multilocularis musashi 0.0057 0.0447 0.0447
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0047 0.0327 0.1872
Mycobacterium ulcerans hypothetical protein 0.0077 0.0689 0.2325
Plasmodium falciparum protein kinase, putative 0.0133 0.1384 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0854 0.1278
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0549 0.1489
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0008
Echinococcus multilocularis tumor protein p63 0.0317 0.3628 0.3628
Echinococcus multilocularis tyrosine protein kinase Srms 0.0021 0.0012 0.0012
Brugia malayi FAT domain containing protein 0.002 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.2845 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0134 0.1392 0.3779
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0059 0.0473 0.3414
Onchocerca volvulus Serine\/threonine kinase homolog 0.0125 0.1276 0.1901
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0227
Echinococcus multilocularis mitogen activated protein kinase 14 0.0162 0.1739 0.1739
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0067 0.0576 0.0649
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0059 0.0473 0.2716
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0572 0.1549
Schistosoma mansoni hypothetical protein 0.005 0.0361 0.0407
Echinococcus granulosus Immunoglobulin 0.0033 0.0153 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.072 0.0812
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0026 0.0076 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0414 0.1373
Loa Loa (eye worm) hypothetical protein 0.0086 0.0807 0.1207
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Echinococcus granulosus CDC7 cell division cycle 7 0.0079 0.072 0.0814
Onchocerca volvulus 0.0021 0.0012 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0108 0.012
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0236 0.0734
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0027 0.0186
Mycobacterium leprae conserved hypothetical protein 0.004 0.0236 0.1271
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.002 0.0001 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0055 0.0062
Toxoplasma gondii aurora kinase 0.0078 0.0712 0.6117
Schistosoma mansoni intermediate filament proteins 0.0057 0.0447 0.0504
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Loa Loa (eye worm) hypothetical protein 0.004 0.0236 0.0353
Echinococcus multilocularis geminin 0.0743 0.8846 0.8846
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Entamoeba histolytica p21-activated kinase 0.0032 0.0146 0.0393
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0236 0.0265
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.002 0.0001 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0689 0.2325
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Echinococcus granulosus tyrosine protein kinase shark 0.0021 0.0012 0.0014
Trypanosoma brucei polo-like protein kinase 0.0125 0.1276 0.7337
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0185
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0162 0.1739 0.2602
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.026 0.293 0.4385
Echinococcus granulosus mitogen activated protein kinase 15 0.002 0.0001 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0027 0.0148
Giardia lamblia Kinase, AGC PKA 0.0059 0.0473 0.1282
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0473 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.274 0.3098
Echinococcus granulosus serine threonine protein kinase nrc 0.0036 0.0188 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0027 0.0148
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.011 0.0124
Loa Loa (eye worm) AGC/AKT protein kinase 0.0061 0.0496 0.0743
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.2577 0.3857
Loa Loa (eye worm) hypothetical protein 0.0077 0.0689 0.1031
Giardia lamblia GTOR 0.0103 0.1011 0.2741
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0212 0.235 0.2657
Brugia malayi hypothetical protein 0.0067 0.0576 0.0859
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.1672 0.5777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.076 0.2061
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Onchocerca volvulus 0.0057 0.0447 0.0659
Chlamydia trachomatis serine/threonine protein kinase 0.026 0.293 1
Echinococcus granulosus defective proboscis extension response 0.0033 0.0153 0.0173
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0213 0.236 0.2667
Loa Loa (eye worm) TK protein kinase 0.0021 0.0012 0.0018
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0036 0.0188 0.0213
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.1456 0.2178
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0114 0.1146 0.659
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.001
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Echinococcus multilocularis lamin 0.0057 0.0447 0.0447
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0072 0.0631 0.0945
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0027 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0262 0.15
Toxoplasma gondii ABC1 family protein 0.004 0.0236 0.1867
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Schistosoma mansoni hypothetical protein 0.006 0.0486 0.0547
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0033 0.0153 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1583 0.1583
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0777 0.0878
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0008 0.0008
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Brugia malayi Furin-like cysteine rich region family protein 0.0084 0.0777 0.116
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0132 0.1369 0.1369
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0108 0.0122
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0029 0.011 0.011
Brugia malayi Protein kinase domain containing protein 0.0061 0.0496 0.0741
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0031 0.0132 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0631 0.0712
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1583 0.2369
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0169
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0058 0.0464 0.3906
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0114
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0854 0.0854
Brugia malayi cyclin-dependent kinase 9 0.0065 0.0548 0.0818
Toxoplasma gondii AGC kinase 0.0059 0.0473 0.3987
Loa Loa (eye worm) TK/INSR protein kinase 0.017 0.1831 0.2741
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0203 0.2234 0.3343
Treponema pallidum fructose-bisphosphate aldolase 0.0321 0.3682 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Mycobacterium ulcerans glutaminase 0.0255 0.2874 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.011 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Schistosoma mansoni tyrosine kinase 0.0071 0.0616 0.0695
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0055 0.0055
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0163 0.0244
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0228 0.2539 0.2539
Onchocerca volvulus 0.0027 0.0076 0.0104
Onchocerca volvulus 0.0021 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.011 0.1102 0.1649
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Entamoeba histolytica PH domain containing protein kinase, putative 0.0038 0.0218 0.0589
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0228 0.2539 0.38
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0163 0.0163
Onchocerca volvulus 0.0057 0.0447 0.0659
Onchocerca volvulus 0.0034 0.0164 0.0235
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0108 0.1077 0.1612
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.003 0.0116 0.0131
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0369
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0078 0.0712 0.193
Loa Loa (eye worm) hypothetical protein 0.0244 0.274 0.4101
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0027 0.0041
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Mycobacterium ulcerans beta-lactamase 0.004 0.0236 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.2071 0.3099
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0008 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.2666 0.3012
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0058 0.0466 0.0698
Onchocerca volvulus 0.0034 0.0168 0.0241
Schistosoma mansoni lamin 0.0057 0.0447 0.0504
Brugia malayi hypothetical protein 0.0033 0.0153 0.0227
Echinococcus multilocularis protein kinase c iota type 0.0041 0.0253 0.0253
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0055 0.0062
Echinococcus granulosus nervana 2 0.0025 0.0055 0.0062
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0565 0.6664 0.6664
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0473 0.0534
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0072 0.0631 0.3625
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Loa Loa (eye worm) CDC7 protein kinase 0.0079 0.072 0.1077
Schistosoma mansoni tyrosine kinase 0.017 0.1831 0.2069
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0046 0.0254
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0132 0.1369 0.1546
Trypanosoma brucei cdc2-related kinase 3 0.0114 0.1146 0.659
Schistosoma mansoni tyrosine kinase 0.0029 0.011 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0236 0.0742
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0042 0.0271 0.0406
Leishmania major protein kinase, putative 0.0078 0.0712 0.4089
Brugia malayi Hr1 repeat family protein 0.0034 0.0163 0.0242
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Schistosoma mansoni vesicular amine transporter 0.0033 0.0153 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Echinococcus granulosus MAM 0.0034 0.0168 0.019
Echinococcus granulosus Cell division cycle 2 protein kinase 0.002 0.0001 0.0002
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0712 0.193
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0327 0.0489
Echinococcus multilocularis Protein kinase C, brain isozyme 0.009 0.0854 0.0854
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0689 0.4025
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0777 0.0878
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0008 0.0008
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0047 0.0324 0.1855
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0068 0.0588 0.3378
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0689 0.2325
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0319 0.0359
Toxoplasma gondii FATC domain-containing protein 0.0042 0.0262 0.2099
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0059 0.0473 0.3987
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0496 0.1344
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0535
Schistosoma mansoni tyrosine kinase 0.0032 0.0143 0.016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Brugia malayi P38 map kinase family protein 2 0.0162 0.1739 0.2601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0027 0.0038
Trypanosoma brucei rac serine-threonine kinase, putative 0.0061 0.0496 0.2849
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Brugia malayi beta-lactamase 0.004 0.0236 0.0351
Loa Loa (eye worm) hypothetical protein 0.0055 0.0424 0.0634
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0689 0.1868
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Schistosoma mansoni glutaminase 0.0255 0.2874 0.3248
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3533 0.3993
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.2071 0.3097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0327 0.0487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0011
Mycobacterium ulcerans hypothetical protein 0.004 0.0236 0.0734
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.011 0.011
Entamoeba histolytica protein kinase domain containing protein 0.0065 0.0548 0.1485
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus aurora kinase A 0.0078 0.0712 0.0805
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0114 0.1146 0.1716
Onchocerca volvulus 0.0022 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0554 0.6531 0.9774
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0086 0.0801 0.4601
Onchocerca volvulus 0.0034 0.0168 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0112
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0047 0.0327 0.0327
Echinococcus granulosus twitchin 0.0051 0.0374 0.0423
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0689 0.2325
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0008 0.0002
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0036 0.0188 0.135
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0231 0.258 0.3862
Trichomonas vaginalis CMGC family protein kinase 0.0072 0.0631 0.1711
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0163 0.0244
Loa Loa (eye worm) hypothetical protein 0.0144 0.151 0.226
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0072 0.0631 0.5397
Loa Loa (eye worm) hypothetical protein 0.0057 0.0452 0.0677
Loa Loa (eye worm) hypothetical protein 0.0033 0.0153 0.0229
Echinococcus granulosus intermediate filament protein 0.0057 0.0447 0.0505
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0023 0.0029 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Trypanosoma cruzi polo-like protein kinase, putative 0.0125 0.1276 0.7337
Schistosoma mansoni protein kinase 0.0078 0.0712 0.0803
Echinococcus granulosus NDR protein kinase 0.0034 0.0163 0.0185
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.011 0.1097 0.1097
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0496 0.1345
Brugia malayi serine/threonine protein kinase 6 0.0078 0.0712 0.1063
Schistosoma mansoni patched 1 0.009 0.0854 0.0964
Loa Loa (eye worm) glutaminase 2 0.0255 0.2874 0.4302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.08 0.217
Echinococcus multilocularis tyrosine kinase 0.0021 0.0012 0.0012
Trichomonas vaginalis STE family protein kinase 0.003 0.0116 0.031
Plasmodium vivax glycogen synthase kinase 3, putative 0.0068 0.0588 0.4246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0081 0.0747 0.643
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0486 0.0549
Echinococcus granulosus mitogen activated protein kinase 14 0.0162 0.1739 0.1966
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0008 0.0008
Leishmania major phosphatidylinositol kinase related protein, putative 0.0024 0.0049 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0236 0.0638
Schistosoma mansoni hypothetical protein 0.0034 0.0168 0.0188
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.034 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Giardia lamblia Kinase, CMGC GSK 0.0068 0.0588 0.1594
Plasmodium vivax protein kinase Crk2 0.0114 0.1146 0.8284
Echinococcus multilocularis PAK box P21 Rho binding 0.003 0.0116 0.0116
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0099 0.0963 0.1442
Echinococcus multilocularis rac serine:threonine kinase 0.0038 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0033 0.0155 0.0231
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0163 0.0163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0262 0.039
Leishmania major hypothetical protein, conserved 0.004 0.0236 0.1351
Echinococcus granulosus tyrosine protein kinase ABL1 0.027 0.306 0.3459
Brugia malayi Pre-SET motif family protein 0.0029 0.0108 0.0159
Entamoeba histolytica hypothetical protein 0.0067 0.0576 0.156
Echinococcus granulosus neuroglian 0.004 0.0241 0.0272
Giardia lamblia Aurora kinase 0.0078 0.0712 0.193
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0078 0.0712 0.0712
Echinococcus multilocularis RNA directed DNA polymerase 0.0048 0.0335 0.0335
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0027 0.007
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0689 0.103
Onchocerca volvulus 0.0068 0.0588 0.0871
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0027 0.007
Brugia malayi cell division control protein 2 homolog 0.011 0.1097 0.1639
Trypanosoma cruzi Protein kinase B 0.0038 0.0218 0.1248
Schistosoma mansoni hypothetical protein 0.0087 0.0814 0.0919
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0047 0.0327 0.0368
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0664 0.0664
Echinococcus granulosus serine/threonine protein kinase 0.0038 0.0218 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0008 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0537 0.1456
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Onchocerca volvulus 0.0022 0.0027 0.003
Echinococcus granulosus serine protein kinase ATM 0.0042 0.0262 0.0296
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0486 0.0549
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1583 0.1788
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0367 0.2101
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0114 0.1146 0.1716
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0008 0.0009
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.002 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Plasmodium falciparum protein kinase 5 0.0114 0.1146 0.8284
Schistosoma mansoni serine/threonine protein kinase 0.026 0.293 0.3311
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.011 0.0124
Echinococcus granulosus insulin growth factor 1 receptor beta 0.017 0.1831 0.207
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0163 0.0163
Brugia malayi beta-lactamase family protein 0.004 0.0236 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0327 0.0884
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0037 0.0209 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0012
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.011 0.011
Onchocerca volvulus 0.004 0.0236 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1583 0.1789
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0076 0.0112
Leishmania major protein kinase A catalytic subunit isoform 1 0.0059 0.0473 0.2716
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.011 0.011
Echinococcus multilocularis tyrosine protein kinase shark 0.0021 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0042 0.0262 0.0708
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0059 0.0473 0.0473
Schistosoma mansoni hypothetical protein 0.0743 0.8846 1
Trypanosoma brucei protein kinase, putative 0.0081 0.0747 0.4294
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0103 0.1011 0.2741
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0361 0.0539
Brugia malayi serine/threonine-protein kinase plk-2 0.0125 0.1276 0.1908
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0067 0.0576 0.0651
Schistosoma mansoni serine/threonine-protein kinase 0.0038 0.0218 0.0245
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0236 0.0742
Leishmania major protein kinase A catalytic subunit isoform 2 0.0059 0.0473 0.2716
Echinococcus multilocularis activin receptor type 0.0024 0.0046 0.0046
Loa Loa (eye worm) TK protein kinase 0.0139 0.1456 0.218
Loa Loa (eye worm) AUR protein kinase 0.0078 0.0712 0.1065
Echinococcus multilocularis nervana 2 0.0025 0.0055 0.0055
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0059 0.0473 0.2716
Loa Loa (eye worm) hypothetical protein 0.0037 0.0209 0.0313
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0163 0.0183
Brugia malayi CHE-14 protein 0.009 0.0854 0.1276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0689 0.2349
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0047 0.0327 0.1872
Loa Loa (eye worm) haspin protein kinase 0.002 0.0001 0.0002
Schistosoma mansoni protein kinase 0.003 0.0116 0.0129
Trypanosoma cruzi target of rapamycin kinase 3 0.0086 0.0801 0.4601
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0026 0.0076 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0321 0.3682 1
Brugia malayi Plexin repeat family protein 0.0021 0.0007 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0084 0.0777 0.1162
Entamoeba histolytica serine/threonine protein kinase, putative 0.0125 0.1276 0.3463
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Schistosoma mansoni tyrosine kinase 0.0084 0.0777 0.0877
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0008 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.1146 0.3111
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0548 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.001
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0162 0.1739 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0203
Trypanosoma brucei protein kinase, putative 0.0068 0.0588 0.3378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0103 0.1011 0.2741
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0163 0.044
Schistosoma mansoni tyrosine kinase 0.0021 0.0012 0.0012
Schistosoma mansoni protein kinase 0.0024 0.0046 0.005
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0194 0.0522
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Entamoeba histolytica protein kinase, putative 0.0061 0.0496 0.1345
Onchocerca volvulus Tyrosine kinase homolog 0.0255 0.2873 0.4294
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0072 0.0631 0.3625
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0854 0.0965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0103 0.1011 0.1511
Echinococcus granulosus tyrosine protein kinase Src64B 0.0029 0.011 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0012 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0236 0.0742
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0021 0.0012 0.0012
Brugia malayi Protein kinase domain containing protein 0.0566 0.6682 1
Echinococcus multilocularis mitogen activated protein kinase 0.0072 0.0631 0.0631
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0712 0.0803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0236 0.0742
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1412 0.1595
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0033 0.0153 0.0171
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0078 0.0712 0.193
Loa Loa (eye worm) hypothetical protein 0.0148 0.1562 0.2338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0108 0.012
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0103 0.1011 0.5808
Loa Loa (eye worm) IKK protein kinase 0.0566 0.6682 1
Mycobacterium tuberculosis Conserved protein 0.004 0.0236 0.0742
Echinococcus multilocularis mitogen activated protein kinase 11 0.0162 0.1739 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0747 0.2025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0095 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0236 0.0638
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.151 0.151
Brugia malayi MH2 domain containing protein 0.0231 0.2577 0.3856
Echinococcus granulosus mitogen activated protein kinase 0.0072 0.0631 0.0714
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0236 0.1351
Trichomonas vaginalis CAMK family protein kinase 0.0125 0.1276 0.3463
Loa Loa (eye worm) hypothetical protein 0.0034 0.0168 0.0252
Entamoeba histolytica cell division protein kinase 2, putative 0.0123 0.1263 0.3426
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0125 0.1276 0.7337
Entamoeba histolytica protein kinase, putative 0.0078 0.0712 0.193
Onchocerca volvulus Putative titin 0.0034 0.0164 0.0235
Onchocerca volvulus 0.0022 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0444
Entamoeba histolytica protein kinase, putative 0.0032 0.0146 0.0393
Loa Loa (eye worm) hypothetical protein 0.0057 0.0447 0.0669
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.072 0.1952
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0078 0.0712 0.193

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.005 uM Inhibition of human Cdc7 assessed as inhibition of rate of phosphorylation of Mcm2 protein ChEMBL. 19115845
IC50 (binding) = 0.096 uM Inhibition of CDK9 ChEMBL. 19115845
IC50 (functional) = 1 uM Antiproliferative activity against human A2780 cells after 72 hrs by luciferase based assay ChEMBL. 19115845

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19115845

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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