TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 692.62 | Formula: C35H32O15
H donors: 3 H acceptors: 7 LogP: 6.66 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)c1cc(cc(c1Oc1cc(C)cc(c1C(=O)OC)O)OC)OC(=O)c1c(O)cc(cc1Oc1c(OC)cc(cc1C(=O)OC)O)C
InChi: 1S/C35H32O15/c1-16-8-22(37)28(34(41)47-7)24(10-16)49-31-21(33(40)46-6)14-19(15-27(31)44-4)48-35(42)29-23(38)9-17(2)11-25(29)50-30-20(32(39)45-5)12-18(36)13-26(30)43-3/h8-15,36-38H,1-7H3
InChiKey: IVXIKZPNFFNFSO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Brugia malayi	Dehydrogenases, short chain protein 30	0.0008	0.0069	0.0079
Brugia malayi	hypothetical protein	0.0008	0.0069	0.0079
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0065	0.1189	0.1372
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0012	0.0132	0.0235
Echinococcus granulosus	dnaJ subfamily B	0.0443	0.8661	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	carbonyl reductase	0.0008	0.0069	0.008
Onchocerca volvulus		0.0008	0.0069	0.0069
Echinococcus granulosus	mixed lineage leukemia protein mll	0.001	0.0104	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1245	0.1437
Brugia malayi	Probable ClpP-like protease	0.0084	0.1559	0.1776
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0008	0.0069	0.008
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0079	0.0091
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0872	0.0993
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0011	0.0122	0.0847
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0012	0.0132	0.0235
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0008	0.0069	0.0025
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.0011	0.0122	0.0356
Loa Loa (eye worm)	inositol-1	0.004	0.0695	0.0791
Giardia lamblia	Hypothetical protein	0.0008	0.0069	0.5
Brugia malayi	MH1 domain containing protein	0.0005	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1189	0.1372
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0012	0.0132	0.0235
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0008	0.0069	0.008
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0695	0.0729
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Onchocerca volvulus	Sepiapterin reductase homolog	0.0008	0.0069	0.0069
Giardia lamblia	Reductase, putative	0.0008	0.0069	0.5
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0069	0.1268	0.4481
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	0.5566
Schistosoma mansoni	hypothetical protein	0.0365	0.7117	0.8217
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0012	0.0132	0.0235
Plasmodium vivax	SET domain protein, putative	0.0065	0.1189	0.7515
Echinococcus multilocularis	cpg binding protein	0.0033	0.0555	0.0565
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0872	0.1007
Schistosoma mansoni	rotamase	0.0036	0.062	0.0716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0872	0.1007
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0132	0.0149
Echinococcus multilocularis	muscleblind protein 1	0.0162	0.3103	0.3531
Trichomonas vaginalis	ferritin, putative	0.0009	0.0086	0.0042
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0132	0.0149
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0008	0.0069	0.0025
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0122	0.0847
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0012	0.0132	0.0235
Onchocerca volvulus		0.0008	0.0069	0.0069
Schistosoma mansoni	inositol monophosphatase	0.004	0.0695	0.0803
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.001	0.0104	0.0041
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Echinococcus multilocularis	tumor protein p63	0.0366	0.7139	0.8228
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0449	0.8776	1
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1245	0.1437
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0012	0.0132	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0012	0.0132	0.0235
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.0989	0.1071
Onchocerca volvulus		0.0065	0.1189	0.1189
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	smad	0.0009	0.0079	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0008	0.0069	0.008
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Brugia malayi	Pre-SET motif family protein	0.0065	0.1189	0.1354
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0012	0.0132	0.0235
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0695	0.0729
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0603	0.8523
Brugia malayi	Temporarily assigned gene name protein 44	0.0029	0.0487	0.0555
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0695	0.0654
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.1256	0.145
Brugia malayi	MH1 domain containing protein	0.0009	0.0079	0.009
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0475	0.2637
Brugia malayi	Muscleblind-like protein	0.0162	0.3103	0.3535
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0008	0.0069	0.0069
Mycobacterium leprae	Conserved hypothetical protein	0.0012	0.0132	0.0422
Brugia malayi	RNA binding protein	0.0068	0.1245	0.1418
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1245	0.1417
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0086	0.0064
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Trichomonas vaginalis	rotamase, putative	0.0036	0.062	0.0578
Echinococcus multilocularis	muscleblind protein	0.0162	0.3103	0.3531
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.062	0.0578
Onchocerca volvulus		0.0008	0.0069	0.0069
Schistosoma mansoni	inositol monophosphatase	0.004	0.0695	0.0803
Schistosoma mansoni	hypothetical protein	0.0012	0.0132	0.0152
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0139	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Echinococcus granulosus	smad	0.0009	0.0079	0.0011
Loa Loa (eye worm)	Smad1	0.0009	0.0079	0.0089
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0132	0.015
Schistosoma mansoni	apoferritin-2	0.0009	0.0086	0.01
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0012	0.0132	0.0235
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0065	0.1189	0.7515
Schistosoma mansoni	cytochrome P450	0.0012	0.0132	0.0152
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0144	0.2746	1
Loa Loa (eye worm)	dehydrogenase	0.0008	0.0069	0.0078
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0069	0.1268	0.805
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0475	0.2722
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0065	0.1189	0.1303
Schistosoma mansoni	ferritin	0.0009	0.0086	0.01
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1116	0.7029
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0012	0.0132	0.0235
Echinococcus multilocularis	expressed protein	0.0036	0.062	0.0641
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0079	0.0011
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0079	0.0089
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0142	0.0084
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0012	0.0132	0.0235
Loa Loa (eye worm)	dehydrogenase	0.0008	0.0069	0.0078
Schistosoma mansoni	hypothetical protein	0.0029	0.0487	0.0562
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Brugia malayi	Inositol-1	0.004	0.0695	0.0792
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0144	0.2746	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	1
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0012	0.0132	0.0235
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0012	0.0132	0.0235
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0035	0.0603	0.8523
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0142	0.0084
Schistosoma mansoni	retinal dehydrogenase	0.0008	0.0069	0.008
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0132	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1559	0.1775
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0079	0.0089
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0964	0.1112
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0012	0.0132	0.0235
Brugia malayi	MH1 domain containing protein	0.0005	0.0001	0.0001
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0012	0.0132	0.1004
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0695	1
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0012	0.0132	0.0235
Echinococcus multilocularis	geminin	0.0365	0.7117	0.8202
Echinococcus granulosus	muscleblind protein	0.0162	0.3103	0.3531
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0872	0.0935
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0695	0.4204
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0487	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0079	0.0091
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0104	0.0041
Echinococcus multilocularis	Smad4	0.0009	0.0079	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0012	0.0132	0.0235
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0012	0.0132	0.0235
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Echinococcus granulosus	expressed protein	0.0036	0.062	0.0641
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0079	0.0011
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.052	0.0591
Brugia malayi	MH2 domain containing protein	0.0009	0.0079	0.009
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.2461	0.2803
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0695	0.5222
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1245	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0132	0.1004
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0012	0.0132	0.0235
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0011	0.0122	0.0356
Brugia malayi	Pre-SET motif family protein	0.0449	0.8776	1
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1245	0.1417
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0012	0.0132	0.0235
Toxoplasma gondii	peptidylprolyl isomerase	0.0035	0.0603	0.3583
Mycobacterium leprae	putative cytochrome p450	0.0012	0.0132	0.0422
Schistosoma mansoni	cpg binding protein	0.0031	0.052	0.06
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0055	0.0989	0.1071
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0008	0.0069	0.0079
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	0.5
Toxoplasma gondii	hypothetical protein	0.0029	0.0475	0.2722
Onchocerca volvulus		0.0008	0.0069	0.0069
Onchocerca volvulus		0.0011	0.0124	0.0124
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0872	0.0935
Schistosoma mansoni	hypothetical protein	0.0365	0.7117	0.8217
Mycobacterium ulcerans	lipoprotein LpqF	0.0069	0.1268	0.4481
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0086	0.0115
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0079	0.0091
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.0132	0.0235
Echinococcus multilocularis	ferritin	0.0009	0.0086	0.002
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Brugia malayi	dehydrogenases, short chain protein 9	0.0008	0.0069	0.0079
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0012	0.0132	0.1004
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0695	0.0654
Brugia malayi	CXXC zinc finger family protein	0.0031	0.052	0.0592
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0132	0.1004
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Onchocerca volvulus		0.0008	0.0069	0.0069
Brugia malayi	tumor suppressor.	0.0349	0.6789	0.7736
Brugia malayi	hypothetical protein	0.0029	0.0487	0.0555
Leishmania major	cytochrome p450-like protein	0.0012	0.0132	0.1004
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0008	0.0069	0.0025
Echinococcus multilocularis	expressed protein	0.0009	0.0086	0.002
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0132	0.015
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0079	0.0091
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0035	0.0603	0.4451
Schistosoma mansoni	Smad4	0.0009	0.0079	0.0091
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0012	0.0132	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0964	0.1097
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Schistosoma mansoni	hypothetical protein	0.0443	0.8661	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1559	1
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0012	0.0132	0.0235
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0012	0.0132	0.0235
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0086	0.0064
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0012	0.0132	0.0235
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0012	0.0132	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0012	0.0132	0.0235
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1559	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Brugia malayi	dehydrogenases, short chain protein 2	0.0008	0.0069	0.0079
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0012	0.0132	0.0235
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0695	0.4204
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0012	0.0132	0.0525
Schistosoma mansoni	cpg binding protein	0.0033	0.0555	0.064
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1245	0.1437
Echinococcus granulosus	protein quaking	0.0029	0.0487	0.0487
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1189	0.1353
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.004	0.0046
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0132	0.0073
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0012	0.0132	0.0422
Schistosoma mansoni	ferritin light chain	0.0009	0.0086	0.01
Leishmania major	cytochrome p450-like protein	0.0012	0.0132	0.1004
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0872	0.0935
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0008	0.0069	0.0069
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1245	0.1437
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0603	0.8523
Brugia malayi	oxidoreductase	0.0008	0.0069	0.0079
Brugia malayi	MH2 domain containing protein	0.0009	0.0079	0.009
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0012	0.0132	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0035	0.0603	0.8523
Echinococcus multilocularis	smad	0.0009	0.0079	0.0011
Onchocerca volvulus		0.0008	0.0069	0.0069
Brugia malayi	Dehydrogenases, short chain protein 2	0.0008	0.0069	0.0079
Onchocerca volvulus		0.0008	0.0069	0.0069
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0872	0.0994
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0872	0.0935
Trypanosoma brucei	beta lactamase	0.0069	0.1268	1
Brugia malayi	Cytochrome P450 family protein	0.0053	0.0949	0.1081
Brugia malayi	MH2 domain containing protein	0.0129	0.2461	0.2804
Echinococcus granulosus	cpg binding protein	0.0033	0.0555	0.0565
Onchocerca volvulus		0.0008	0.0069	0.0069
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.001	0.0104	0.012
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.0613	0.3648
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0084	0.1559	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0695	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0055	0.0989	0.3437
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0055	0.0989	0.3437
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0008	0.0069	0.0025
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.0989	0.6175
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	0.5566
Loa Loa (eye worm)	tumor suppressor	0.0349	0.6789	0.7736
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1245	0.1437
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Schistosoma mansoni	ferritin	0.0009	0.0086	0.01
Trichomonas vaginalis	rotamase, putative	0.0035	0.0603	0.0561
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0008	0.0069	0.0079
Echinococcus multilocularis		0.0012	0.0132	0.0073
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0695	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0012	0.0132	0.0235
Schistosoma mansoni	apoferritin-2	0.0009	0.0086	0.01
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0012	0.0132	0.0235
Brugia malayi	Smad1	0.0009	0.0079	0.009
Schistosoma mansoni	ferritin	0.0009	0.0086	0.01
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0008	0.0069	0.0078
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.0949	0.108
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0132	0.0149
Schistosoma mansoni	cpg binding protein	0.0033	0.0555	0.064
Brugia malayi	hypothetical protein	0.0008	0.0069	0.0079
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0086	0.0115
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0008	0.0069	0.0079
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0036	0.062	0.0706
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0086	0.0064
Schistosoma mansoni	carbonyl reductase	0.0008	0.0069	0.008
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0079	0.0011
Onchocerca volvulus		0.0008	0.0069	0.0069
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0008	0.0069	0.0069
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0132	0.015
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0012	0.0132	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0012	0.0132	0.0235
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0065	0.1189	0.1303
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0012	0.0132	0.0235
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0029	0.0475	0.2722
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Echinococcus granulosus	ferritin	0.0009	0.0086	0.002
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0084	0.1559	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0062	0.1129	0.1233
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Schistosoma mansoni	carbonyl reductase	0.0008	0.0069	0.008
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	1
Echinococcus granulosus	Smad4	0.0009	0.0079	0.0011
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0012	0.0132	0.0235
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0012	0.0132	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3103	0.3535
Onchocerca volvulus		0.0054	0.0964	0.0964
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0872	0.1007
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0132	0.0525
Brugia malayi	cytochrome P450	0.0012	0.0132	0.015
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0132	0.0149
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0086	0.0064
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0012	0.0132	0.0235
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0012	0.0132	0.0235
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1189	0.1372
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Echinococcus granulosus	expressed protein	0.0009	0.0086	0.002
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0475	0.2722
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0104	0.0041
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1559	1
Echinococcus granulosus	hypothetical protein	0.0029	0.0487	0.0487
Brugia malayi	MH1 domain containing protein	0.0009	0.0079	0.009
Brugia malayi	TAR-binding protein	0.0068	0.1245	0.1418
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1245	0.1368
Schistosoma mansoni	ferritin	0.0009	0.0086	0.01
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0012	0.0132	0.0235
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1245	0.1368
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0008	0.0069	0.5
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0613	0.203
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0069	0.0078
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1245	0.1417
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0142	0.016
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0084	0.1559	0.1734
Schistosoma mansoni	steroid dehydrogenase	0.0008	0.0069	0.008
Echinococcus granulosus	tumor protein p63	0.0366	0.7139	0.8228
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0122	0.0847
Onchocerca volvulus		0.0008	0.0069	0.0069
Echinococcus multilocularis	dnaJ subfamily B	0.0443	0.8661	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0122	0.0442
Echinococcus granulosus	geminin	0.0365	0.7117	0.8202
Schistosoma mansoni	hypothetical protein	0.0029	0.0487	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Onchocerca volvulus		0.0031	0.052	0.052
Onchocerca volvulus		0.0008	0.0069	0.0069
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0084	0.1559	0.1734
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Onchocerca volvulus		0.0008	0.0069	0.0069
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Schistosoma mansoni	ferritin light chain	0.0009	0.0086	0.01
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0069	0.0078
Leishmania major	cytochrome p450-like protein	0.0012	0.0132	0.1004
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0012	0.0132	0.0235
Giardia lamblia	Short-chain dehydrogenase, putative	0.0008	0.0069	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0069	0.0079
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Onchocerca volvulus		0.0008	0.0069	0.0069
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.2461	0.2803
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0036	0.062	0.0705
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0695	0.0654
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0012	0.0132	0.0235
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.1189	0.1372
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0012	0.0132	0.0235
Echinococcus multilocularis	protein quaking	0.0029	0.0487	0.0487
Schistosoma mansoni	peptidase Clp (S14 family)	0.0084	0.1559	0.18
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0132	0.1004
Echinococcus granulosus	histone lysine methyltransferase setb	0.0065	0.1189	0.1303
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0008	0.0069	0.0025
Schistosoma mansoni	short chain dehydrogenase	0.0008	0.0069	0.008
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0079	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3103	0.3535
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0695	0.234
Brugia malayi	Retinol dehydrogenase 12	0.0008	0.0069	0.0079

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 50 uM	Antimicrobial activity against Escherichia coli CGMCC 1.2340	ChEMBL.	18720971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL501396

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1179383