Detailed information for compound 1188819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 756.93 | Formula: C42H56N6O7
  • H donors: 6 H acceptors: 7 LogP: 6.9 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H](C(=O)NCc1nc2c([nH]1)cccc2)NC(=O)[C@@H](C([C@@H]([C@@H](NC(=O)c1ncccc1OCOc1ccccc1)CC1CCCCC1)O)O)C(C)C)C
  • InChi: 1S/C42H56N6O7/c1-5-27(4)36(41(52)44-24-34-45-30-19-12-13-20-31(30)46-34)48-40(51)35(26(2)3)39(50)38(49)32(23-28-15-8-6-9-16-28)47-42(53)37-33(21-14-22-43-37)55-25-54-29-17-10-7-11-18-29/h7,10-14,17-22,26-28,32,35-36,38-39,49-50H,5-6,8-9,15-16,23-25H2,1-4H3,(H,44,52)(H,45,46)(H,47,53)(H,48,51)/t27-,32-,35+,36-,38+,39?/m0/s1
  • InChiKey: POAHQWRONFGSFM-OGSQEYEMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Delta serrate ligand family protein 0.0105 0.0302 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Echinococcus multilocularis mitogen activated protein kinase 3 0.0158 0.0527 0.2589
Echinococcus granulosus fibropellin Ia 0.0105 0.0302 0.1453
Loa Loa (eye worm) cytochrome P450 family protein 0.0205 0.0724 0.1417
Schistosoma mansoni hypothetical protein 0.0655 0.2618 0.4157
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0131 0.0412 0.3313
Schistosoma mansoni tfiia large subunit 0.0211 0.0747 0.1186
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0217 0.1365
Brugia malayi Cytochrome P450 family protein 0.0334 0.1266 0.2498
Brugia malayi follicle stimulating hormone receptor 0.1227 0.5027 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.039 0.1503 0.7649
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0235 0.085 0.2745
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.028 0.1039 0.1651
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.0527 0.0836
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0131 0.0412 0.3313
Schistosoma mansoni cytochrome P450 0.0131 0.0412 0.0654
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0131 0.0412 0.3313
Schistosoma mansoni caspase-3 (C14 family) 0.0507 0.1994 0.3167
Loa Loa (eye worm) hypothetical protein 0.0238 0.0862 0.1691
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0217 0.1044
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0203 0.0716 0.0703
Schistosoma mansoni notch 0.0105 0.0302 0.0479
Echinococcus multilocularis caspase 0.0507 0.1994 1
Echinococcus multilocularis 0.0063 0.0126 0.0563
Trypanosoma cruzi metacaspase, putative 0.0203 0.0716 0.3608
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.039 0.1503 0.7649
Onchocerca volvulus 0.0105 0.0302 0.0944
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0131 0.0412 0.3313
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0131 0.0412 0.3313
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Trypanosoma brucei Metacaspase-4 0.0203 0.0716 0.472
Toxoplasma gondii calcium binding egf domain-containing protein 0.02 0.07 0.0687
Schistosoma mansoni carbonyl reductase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0063 0.0126 0.0222
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0037 0.0014 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0232 0.0835 0.1327
Brugia malayi Fibulin-1 precursor 0.02 0.07 0.1368
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0043 0.0144
Echinococcus multilocularis tfiia large subunit 0.0211 0.0747 0.3702
Schistosoma mansoni hypothetical protein 0.0049 0.0064 0.0101
Onchocerca volvulus 0.0105 0.0302 0.0944
Onchocerca volvulus Putative cubilin 0.0128 0.0399 0.1262
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0064 0.0099
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus glycoprotein Antigen 5 0.0344 0.131 0.6546
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.1199 0.9875
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0318 0.1199 0.9875
Toxoplasma gondii PAN domain-containing protein 0.0235 0.085 0.0837
Brugia malayi bHLH-PAS transcription factor 0.0075 0.0174 0.0319
Mycobacterium ulcerans putative regulatory protein 0.0075 0.0174 0.1333
Brugia malayi hypothetical protein 0.0216 0.077 0.1507
Trypanosoma brucei short-chain dehydrogenase, putative 0.0037 0.0014 0.0006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.039 0.1503 0.7521
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0131 0.0412 0.3313
Brugia malayi Calcium binding EGF domain containing protein 0.0105 0.0302 0.0574
Leishmania major hypothetical protein, conserved 0.0499 0.1961 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0499 0.1961 0.3883
Schistosoma mansoni lipoxygenase 0.0082 0.0206 0.0328
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0203 0.0716 0.1401
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.02 0.07 0.1368
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0131 0.0412 0.2042
Leishmania major cytochrome p450-like protein 0.0205 0.0724 0.3649
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus multilocularis neurogenic locus notch protein 0.0105 0.0302 0.1453
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0232 0.0835 0.1327
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0322 0.1214 0.1928
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.0236 0.0375
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.6296 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0037 0.0014 0.0006
Echinococcus multilocularis notch 0.0105 0.0302 0.1453
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0131 0.0412 0.3313
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.039 0.1503 1
Echinococcus granulosus dna polymerase kappa 0.0044 0.0043 0.0144
Trypanosoma cruzi metacaspase, putative 0.0203 0.0716 0.3608
Echinococcus granulosus apoptotic protease activating factor 1 0.0216 0.077 0.3816
Loa Loa (eye worm) hypothetical protein 0.0655 0.2618 0.5194
Brugia malayi Protein kinase domain containing protein 0.0065 0.0134 0.0239
Leishmania major cytochrome p450-like protein 0.0131 0.0412 0.2042
Trypanosoma cruzi hypothetical protein, conserved 0.0499 0.1961 1
Onchocerca volvulus 0.0216 0.077 0.248
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Onchocerca volvulus 0.0235 0.085 0.2745
Schistosoma mansoni cell polarity protein 0.0105 0.0302 0.0479
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0232 0.0835 0.4148
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0067 0.0143 0.0226
Trypanosoma brucei metacaspase MCA3 0.0203 0.0716 0.472
Plasmodium falciparum metacaspase 1 0.0203 0.0716 0.3608
Brugia malayi hypothetical protein 0.0339 0.1286 0.2538
Loa Loa (eye worm) hypothetical protein 0.042 0.1627 0.3217
Echinococcus multilocularis Tolloid protein 1 0.0223 0.0797 0.3953
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Echinococcus granulosus Mastin 0.0344 0.131 0.6546
Loa Loa (eye worm) PAN domain-containing protein 0.0235 0.085 0.1668
Brugia malayi MAP kinase sur-1 0.0158 0.0527 0.1022
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0131 0.0412 0.3313
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Onchocerca volvulus 0.0232 0.0835 0.2696
Brugia malayi CUB domain containing protein 0.0048 0.0063 0.0098
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0232 0.0835 0.4148
Onchocerca volvulus 0.0235 0.085 0.2745
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0065 0.0134 0.0809
Brugia malayi Calcium binding EGF domain containing protein 0.02 0.07 0.1368
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Schistosoma mansoni caspase-7 (C14 family) 0.042 0.1627 0.2584
Loa Loa (eye worm) CYP4Cod1 0.0205 0.0724 0.1417
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0158 0.0527 0.1022
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0223 0.0797 0.1265
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Toxoplasma gondii microneme protein MIC17A 0.0235 0.085 0.0837
Schistosoma mansoni hypothetical protein 0.0131 0.0412 0.0654
Loa Loa (eye worm) Notch2 0.0105 0.0302 0.0574
Toxoplasma gondii PAN/Apple domain-containing protein 0.0235 0.085 0.0837
Echinococcus multilocularis caspase 2 0.042 0.1627 0.8146
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0862 0.4282
Schistosoma mansoni aldehyde dehydrogenase 0.0318 0.1199 0.1904
Onchocerca volvulus 0.0655 0.2618 0.8547
Schistosoma mansoni caspase-7 (C14 family) 0.0507 0.1994 0.3167
Loa Loa (eye worm) acetyltransferase 0.0315 0.1188 0.2341
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Trypanosoma brucei short-chain dehydrogenase, putative 0.0037 0.0014 0.0006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0322 0.1214 1
Toxoplasma gondii aldehyde dehydrogenase 0.0318 0.1199 0.1186
Echinococcus multilocularis ubiquitin specific protease 41 0.039 0.1503 0.7521
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0131 0.0412 0.2042
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0131 0.0412 0.3313
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0232 0.0835 0.1638
Onchocerca volvulus 0.0235 0.085 0.2745
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.0527 0.2633
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Onchocerca volvulus 0.0235 0.085 0.2745
Echinococcus granulosus notch 0.0105 0.0302 0.1453
Mycobacterium ulcerans hypothetical protein 0.0232 0.0835 0.6845
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0318 0.1199 0.5984
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Loa Loa (eye worm) DOMON domain-containing protein 0.0655 0.2618 0.5194
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0131 0.0412 0.3313
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0322 0.1214 0.606
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0131 0.0412 0.3313
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0158 0.0527 0.3446
Loa Loa (eye worm) cytochrome P450 family protein 0.0334 0.1266 0.2498
Brugia malayi Kringle domain containing protein 0.0499 0.1961 0.3883
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0322 0.1214 0.6164
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0043 0.0238
Loa Loa (eye worm) hypothetical protein 0.0133 0.0418 0.0805
Toxoplasma gondii microneme protein MIC17C 0.0235 0.085 0.0837
Onchocerca volvulus 0.0235 0.085 0.2745
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0131 0.0412 0.2042
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0322 0.1214 0.606
Onchocerca volvulus 0.0232 0.0835 0.2696
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0203 0.0716 0.0703
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0275 0.102 0.2006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0232 0.0835 0.1327
Echinococcus multilocularis mitogen activated protein kinase 0.0158 0.0527 0.2589
Loa Loa (eye worm) trypsin family protein 0.0232 0.0835 0.1638
Schistosoma mansoni hypothetical protein 0.0232 0.0835 0.1327
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0205 0.0724 0.1417
Trypanosoma brucei cytochrome P450, putative 0.0205 0.0724 0.4774
Onchocerca volvulus 0.0049 0.0064 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0043 0.0146
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0134 0.0614
Onchocerca volvulus 0.0655 0.2618 0.8547
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Trypanosoma cruzi cytochrome P450, putative 0.0205 0.0724 0.3649
Echinococcus granulosus protein jagged 2 0.0105 0.0302 0.1453
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0037 0.0014 0.0006
Brugia malayi Calcium binding EGF domain containing protein 0.0128 0.0399 0.0767
Trypanosoma cruzi metacaspase 5, putative 0.0203 0.0716 0.3608
Loa Loa (eye worm) hypothetical protein 0.076 0.306 0.6077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0322 0.1214 1
Echinococcus granulosus neurogenic locus notch protein 0.0105 0.0302 0.1453
Loa Loa (eye worm) hypothetical protein 0.005 0.0069 0.0109
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.025 0.1583
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.013 0.0206
Brugia malayi cytochrome P450 0.0131 0.0412 0.0793
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0131 0.0412 0.3313
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus hypothetical protein 0.0063 0.0126 0.0563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0043 0.0146
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0232 0.0835 0.1327
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0105 0.0302 0.0479
Echinococcus multilocularis glycoprotein Antigen 5 0.0344 0.131 0.6546
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.039 0.1503 0.7521
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Echinococcus granulosus neurogenic locus notch protein 4 0.0105 0.0302 0.1453
Echinococcus multilocularis dual specificity protein kinase clk2 0.0065 0.0134 0.0604
Echinococcus granulosus neurogenic locus notch protein 0.0105 0.0302 0.1453
Schistosoma mansoni hypothetical protein 0.0431 0.1675 0.2661
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0235 0.085 0.2745
Mycobacterium leprae putative cytochrome p450 0.0131 0.0412 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.039 0.1503 0.2387
Toxoplasma gondii PAN domain-containing protein 0.0235 0.085 0.0837
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.0236 0.1121
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Brugia malayi Muscle positioning protein 4 0.076 0.306 0.6077
Echinococcus multilocularis tfiia large subunit 0.0211 0.0747 0.3702
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0037 0.0014 0.0006
Onchocerca volvulus 0.076 0.306 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0131 0.0412 0.3313
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0131 0.0412 0.3313
Trypanosoma brucei short-chain dehydrogenase, putative 0.0037 0.0014 0.0006
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0158 0.0527 0.2633
Echinococcus granulosus delta-like protein 1 0.0105 0.0302 0.1453
Schistosoma mansoni survival motor neuron protein 0.0049 0.0064 0.0101
Echinococcus multilocularis caspase 3 0.0303 0.1137 0.567
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0158 0.0527 0.2633
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0131 0.0412 0.3313
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.039 0.1503 0.7649
Leishmania major protein kinase, putative 0.0065 0.0134 0.0614
Onchocerca volvulus 0.0105 0.0302 0.0944
Plasmodium falciparum cysteine repeat modular protein 1 0.0499 0.1961 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Trypanosoma brucei oxidoreductase-like protein 0.0037 0.0014 0.0006
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0862 0.4282
Loa Loa (eye worm) hypothetical protein 0.0499 0.1961 0.3883
Schistosoma mansoni egf-like domain protein 0.02 0.07 0.1111
Echinococcus multilocularis enteropeptidase 0.0344 0.131 0.6546
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus laminin 0.02 0.07 0.3464
Loa Loa (eye worm) hypothetical protein 0.02 0.07 0.1368
Echinococcus multilocularis tissue type plasminogen activator 0.0499 0.1961 0.9833
Loa Loa (eye worm) hypothetical protein 0.0339 0.1286 0.2538
Echinococcus multilocularis fat cadherin tumor suppressor 0.0105 0.0302 0.1453
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0065 0.0134 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0043 0.0198
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Echinococcus granulosus caspase 0.0507 0.1994 1
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0043 0.0238
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0133 0.0119
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0223 0.0797 0.1561
Giardia lamblia Kinase, CMGC CLK 0.0065 0.0134 0.0803
Brugia malayi Transcription factor IIA, alpha/beta subunit family protein 0.0211 0.0747 0.1462
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0131 0.0412 0.2674
Brugia malayi hypothetical protein 0.0232 0.0835 0.1638
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.0174 0.0808
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0356 0.1726
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Echinococcus granulosus Tolloid protein 1 0.0223 0.0797 0.3953
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0318 0.1199 0.6086
Schistosoma mansoni notch 0.0105 0.0302 0.0479
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0131 0.0412 0.3313
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.039 0.1503 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0499 0.1961 1
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Trypanosoma brucei metacaspase 5, putative 0.0203 0.0716 0.472
Brugia malayi notch-like transmembrane receptor 0.0105 0.0302 0.0574
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.025 0.1211
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0131 0.0412 0.3313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0043 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0131 0.0412 0.3313
Brugia malayi SEA domain containing protein 0.0655 0.2618 0.5194
Echinococcus multilocularis slit 2 protein 0.0105 0.0302 0.1453
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0318 0.1199 0.5984
Brugia malayi Cytochrome P450 family protein 0.0205 0.0724 0.1417
Schistosoma mansoni retinal dehydrogenase 0.0037 0.0014 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0043 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Toxoplasma gondii calcium binding egf domain-containing protein 0.02 0.07 0.0687
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Echinococcus granulosus dual specificity protein kinase clk2 0.0065 0.0134 0.0604
Trypanosoma brucei protein kinase, putative 0.0158 0.0527 0.3446
Echinococcus granulosus tumor protein p63 0.034 0.1292 0.6454
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Toxoplasma gondii hypothetical protein 0.0235 0.085 0.0837
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0098
Echinococcus granulosus slit 2 protein 0.0105 0.0302 0.1453
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.039 0.1503 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0074 0.0172 0.0315
Toxoplasma gondii PAN domain-containing protein 0.0235 0.085 0.0837
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.039 0.1503 0.7521
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.039 0.1503 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0232 0.0835 0.1327
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0131 0.0412 0.3313
Toxoplasma gondii hypothetical protein 0.0235 0.085 0.0837
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0158 0.0527 0.0513
Onchocerca volvulus 0.0075 0.0174 0.0525
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0285 0.1059 0.2084
Loa Loa (eye worm) hypothetical protein 0.02 0.07 0.1368
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.1675 0.8392
Trichomonas vaginalis conserved hypothetical protein 0.039 0.1503 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0527 0.3442
Echinococcus granulosus tfiia large subunit 0.0211 0.0747 0.3702
Onchocerca volvulus Arrow homolog 0.0225 0.0807 0.2603
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1227 0.5027 1
Brugia malayi Protein kinase domain containing protein 0.0499 0.1961 0.3883
Trypanosoma brucei metacaspase 0.0203 0.0716 0.472
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.039 0.1503 0.2387
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0315 0.1188 0.5927
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0089 0.0236 0.0443
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.0285 0.0452
Plasmodium vivax serine/threonine kinase-1, putative 0.0065 0.0134 0.0614
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) cytochrome P450 0.0131 0.0412 0.0793
Loa Loa (eye worm) transcription factor IIA 0.0211 0.0747 0.1462
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0131 0.0412 0.3313
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.1199 0.9875
Brugia malayi Cadherin domain containing protein 0.0105 0.0302 0.0574
Onchocerca volvulus 0.0105 0.0302 0.0944
Brugia malayi PAS domain containing protein 0.0101 0.0285 0.054
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0315 0.1188 0.1886
Brugia malayi Trypsin family protein 0.0232 0.0835 0.1638
Schistosoma mansoni slit 0.0105 0.0302 0.0479
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Schistosoma mansoni laminin gamma-3 chain 0.0105 0.0302 0.0479
Leishmania major cytochrome p450-like protein 0.0131 0.0412 0.2042
Schistosoma mansoni notch 0.0105 0.0302 0.0479
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0065 0.0134 0.0239
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Plasmodium falciparum protein serine/threonine kinase-1 0.0065 0.0134 0.0614
Echinococcus granulosus enteropeptidase 0.0344 0.131 0.6546
Echinococcus granulosus neural cadherin 0.0105 0.0302 0.1453
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0655 0.2618 0.8547
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Toxoplasma gondii microneme protein, putative 0.0235 0.085 0.0837
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0065 0.0134 0.0809
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.103 0.1635
Onchocerca volvulus 0.0232 0.0835 0.2696
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Echinococcus granulosus single minded 2 0.0075 0.0174 0.0808
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Toxoplasma gondii PAN domain-containing protein 0.0235 0.085 0.0837
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0043 0.0191
Echinococcus multilocularis neurogenic locus protein delta 0.0105 0.0302 0.1453
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0235 0.085 0.0837
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0216 0.077 0.1507
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.039 0.1503 1
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Echinococcus multilocularis apoptotic protease activating factor 1 0.0216 0.077 0.3816
Echinococcus multilocularis neurogenic locus notch protein 0.0105 0.0302 0.1453
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Schistosoma mansoni aldehyde dehydrogenase 0.0318 0.1199 0.1904
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0131 0.0412 0.3313
Onchocerca volvulus Cell death protein 3 homolog 0.042 0.1627 0.5295
Leishmania major protein kinase, putative 0.0065 0.0134 0.0614
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0158 0.0527 0.2633
Onchocerca volvulus 0.0235 0.085 0.2745
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0217 0.1365
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0131 0.0412 0.3313
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0134 0.0212
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0255 0.0932 0.1481
Echinococcus multilocularis fibrillin 1 0.02 0.07 0.3464
Brugia malayi Cytochrome P450 family protein 0.0131 0.0412 0.0793
Brugia malayi Trypsin-like protease protein 5 0.0232 0.0835 0.1638
Leishmania major metacaspase, putative 0.0203 0.0716 0.3608
Echinococcus multilocularis tumor protein p63 0.034 0.1292 0.6454
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.025 0.0236
Loa Loa (eye worm) PAN domain-containing protein 0.0235 0.085 0.1668
Brugia malayi Cadherin domain containing protein 0.0105 0.0302 0.0574
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0232 0.0835 0.2696
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.025 0.1191
Schistosoma mansoni hypothetical protein 0.0499 0.1961 0.3114
Brugia malayi acetyltransferase, GNAT family protein 0.0315 0.1188 0.2341
Echinococcus multilocularis 0.0131 0.0412 0.2008
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0205 0.0724 0.592
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Loa Loa (eye worm) hypothetical protein 0.0223 0.0797 0.1561
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0232 0.0835 0.4148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0043 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0069 0.0109
Schistosoma mansoni single-minded 0.0101 0.0285 0.0452
Brugia malayi Cytochrome P450 family protein 0.0205 0.0724 0.1417
Onchocerca volvulus 0.0089 0.0236 0.0729
Plasmodium vivax transcription initiation factor IIA subunit 1, putative 0.008 0.0194 0.0926
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0105 0.0302 0.0944
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0131 0.0412 0.3313
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Onchocerca volvulus 0.0232 0.0835 0.2696
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0232 0.0835 0.4148
Echinococcus multilocularis neurogenic locus protein delta 0.0105 0.0302 0.1453
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0356 0.1726
Loa Loa (eye worm) hypothetical protein 0.0128 0.0399 0.0767
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0134 0.0614
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0507 0.1994 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Loa Loa (eye worm) hypoxia-induced factor 1 0.0312 0.1176 0.2317
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0105 0.0302 0.0574
Brugia malayi Trypsin family protein 0.0232 0.0835 0.1638
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0134 0.0212
Loa Loa (eye worm) notch protein 0.0105 0.0302 0.0574
Onchocerca volvulus Slit protein homolog 0.0105 0.0302 0.0944
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0158 0.0527 0.2633
Trypanosoma cruzi cytochrome P450, putative 0.0205 0.0724 0.3649
Echinococcus granulosus mitogen activated protein kinase 3 0.0158 0.0527 0.2589
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.0236 0.0443
Mycobacterium ulcerans aldehyde dehydrogenase 0.0318 0.1199 0.9875
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0527 0.3442
Onchocerca volvulus Neurogenic locus notch homolog 0.0105 0.0302 0.0944
Echinococcus multilocularis fibropellin Ia 0.0105 0.0302 0.1453
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.039 0.1503 0.297
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0131 0.0412 0.3313
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Echinococcus multilocularis caspase 8 0.0203 0.0716 0.3548
Echinococcus multilocularis protein jagged 2 0.0105 0.0302 0.1453
Toxoplasma gondii microneme protein MIC17B 0.0235 0.085 0.0837
Echinococcus granulosus dnaJ subfamily B 0.0431 0.1675 0.8392
Echinococcus granulosus ubiquitin specific protease 41 0.039 0.1503 0.7521
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.0236 0.1121
Loa Loa (eye worm) hypothetical protein 0.0203 0.0716 0.1401
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0322 0.1214 0.2394
Echinococcus granulosus tfiia large subunit 0.0211 0.0747 0.3702
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Echinococcus granulosus caspase 3 0.0303 0.1137 0.567
Trypanosoma brucei short-chain dehydrogenase, putative 0.0037 0.0014 0.0006
Brugia malayi Cell death protein 3 precursor 0.042 0.1627 0.3217
Toxoplasma gondii microneme protein MIC4 0.0235 0.085 0.0837
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Plasmodium vivax metacaspase 1, putative 0.0203 0.0716 0.3608
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.025 0.1583
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus protein jagged 1 0.0105 0.0302 0.1453
Schistosoma mansoni carbonyl reductase 0.0037 0.0014 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0131 0.0412 0.3313
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus caspase 8 0.0203 0.0716 0.3548
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Schistosoma mansoni cercarial elastase (S01 family) 0.0232 0.0835 0.1327
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0203 0.0716 0.4717
Brugia malayi Trypsin family protein 0.0232 0.0835 0.1638
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0232 0.0835 0.2696
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0065 0.0134 0.012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0158 0.0527 0.2633
Schistosoma mansoni carbonyl reductase 0.0037 0.0014 0.0022
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0131 0.0412 0.3313
Trypanosoma cruzi metacaspase 5, putative 0.0203 0.0716 0.3608
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0225 0.0807 0.1582
Schistosoma mansoni hypothetical protein 0.0105 0.0302 0.0479
Mycobacterium leprae Conserved hypothetical protein 0.0131 0.0412 1
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0527 0.3442
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.025 0.0236
Echinococcus granulosus protein jagged 2 0.0105 0.0302 0.1453
Toxoplasma gondii kringle domain-containing protein 0.0499 0.1961 0.1949
Echinococcus multilocularis transmembrane protease serine 3 0.0232 0.0835 0.4148
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0131 0.0412 0.3313
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Toxoplasma gondii subtilisin SUB12 0.0235 0.085 0.0837
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0203 0.0716 0.0703
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0037 0.0014 0.0022
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0037 0.0014 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0131 0.0412 0.3313
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0232 0.0835 0.1327
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0131 0.0412 0.3313
Echinococcus multilocularis neurogenic locus notch protein 4 0.0105 0.0302 0.1453
Onchocerca volvulus 0.0235 0.085 0.2745
Brugia malayi hypoxia-induced factor 1 0.0312 0.1176 0.2317
Brugia malayi Trypsin family protein 0.0232 0.0835 0.1638
Echinococcus granulosus tissue type plasminogen activator 0.0499 0.1961 0.9833
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0037 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0232 0.0835 0.1638
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Giardia lamblia High cysteine protein 0.0105 0.0302 0.1932
Echinococcus granulosus mitogen activated protein kinase 0.0158 0.0527 0.2589
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0131 0.0412 0.3313
Echinococcus multilocularis protein jagged 1 0.0105 0.0302 0.1453
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Echinococcus granulosus cytochrome P450 2K1 0.0131 0.0412 0.2008
Echinococcus multilocularis neural cadherin 0.0105 0.0302 0.1453
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.115 0.5739
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Onchocerca volvulus 0.0235 0.085 0.2745
Echinococcus multilocularis laminin 0.02 0.07 0.3464
Schistosoma mansoni septate junction protein 0.0105 0.0302 0.0479
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0131 0.0412 0.3313
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0131 0.0412 0.3313
Onchocerca volvulus 0.0235 0.085 0.2745
Onchocerca volvulus 0.0655 0.2618 0.8547
Echinococcus granulosus neurogenic locus protein delta 0.0105 0.0302 0.1453
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0198
Echinococcus granulosus protein jagged 1 0.0105 0.0302 0.1453
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0065 0.0134 0.0614
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0131 0.0412 0.3313
Schistosoma mansoni lipoxygenase 0.0118 0.0356 0.0565
Schistosoma mansoni tfiia large subunit 0.0211 0.0747 0.1186
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.0527 0.3442
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0037 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0105 0.0302 0.0574
Brugia malayi GCC2 and GCC3 family protein 0.0133 0.0418 0.0805
Toxoplasma gondii cytochrome p450 superfamily protein 0.0131 0.0412 0.0398
Plasmodium falciparum metacaspase-like protein 0.0203 0.0716 0.3608
Echinococcus granulosus transmembrane protease serine 3 0.0232 0.0835 0.4148
Loa Loa (eye worm) PAN domain-containing protein 0.0235 0.085 0.1668
Giardia lamblia Kinase, CMGC MAPK 0.0158 0.0527 0.3442
Schistosoma mansoni steroid dehydrogenase 0.0037 0.0014 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0131 0.0412 0.3313
Echinococcus granulosus caspase 2 0.042 0.1627 0.8146
Schistosoma mansoni short chain dehydrogenase 0.0037 0.0014 0.0022
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0507 0.1994 1
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Loa Loa (eye worm) PAN domain-containing protein 0.0235 0.085 0.1668
Loa Loa (eye worm) hypothetical protein 0.0225 0.0807 0.1582
Brugia malayi Calcium binding EGF domain containing protein 0.0105 0.0302 0.0574
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0225 0.0807 0.1582
Brugia malayi hypothetical protein 0.0238 0.0862 0.1691
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0037 0.0014 0.0006
Onchocerca volvulus 0.005 0.0069 0.018
Onchocerca volvulus 0.0499 0.1961 0.6391
Trypanosoma brucei metacaspase MCA2 0.0203 0.0716 0.472
Trypanosoma cruzi metacaspase, putative 0.0203 0.0716 0.3608
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0037 0.0014 0.0022
Schistosoma mansoni notch 0.0105 0.0302 0.0479
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0344 0.131 0.2081
Toxoplasma gondii EGF family domain-containing protein 0.0105 0.0302 0.0288
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0322 0.1214 1
Trichomonas vaginalis CMGC family protein kinase 0.0065 0.0134 0.0803
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0716 0.4717
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0203 0.0716 0.1138
Trypanosoma cruzi metacaspase, putative 0.0203 0.0716 0.3608
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0131 0.0412 0.3313
Echinococcus multilocularis Mastin 0.0344 0.131 0.6546
Schistosoma mansoni hypothetical protein 0.0216 0.077 0.1222
Brugia malayi EGF-like domain containing protein 0.0105 0.0302 0.0574
Loa Loa (eye worm) hypothetical protein 0.0235 0.085 0.1668
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.039 0.1503 0.7521
Plasmodium vivax hypothetical protein, conserved 0.0203 0.0716 0.3608
Loa Loa (eye worm) PAN domain-containing protein 0.0235 0.085 0.1668
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0043 0.0191
Brugia malayi PAN domain containing protein 0.0235 0.085 0.1668
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0131 0.0412 0.2042
Schistosoma mansoni notch 0.0105 0.0302 0.0479
Loa Loa (eye worm) hypothetical protein 0.039 0.1503 0.297
Echinococcus multilocularis protein jagged 1 0.0105 0.0302 0.1453
Schistosoma mansoni notch 0.0105 0.0302 0.0479

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.268 Inhibitory activity against HIV-1 Protease ChEMBL. 8035428

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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