Detailed information for compound 1212535

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 521.608 | Formula: C28H35N5O5
  • H donors: 2 H acceptors: 3 LogP: 3.56 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)N/C(=N\C(=O)c1cccc(c1)OC)/N[C@H]1CCCCN(C1=O)CC(=O)N1CCCC1
  • InChi: 1S/C28H35N5O5/c1-37-22-13-11-21(12-14-22)29-28(31-26(35)20-8-7-9-23(18-20)38-2)30-24-10-3-4-17-33(27(24)36)19-25(34)32-15-5-6-16-32/h7-9,11-14,18,24H,3-6,10,15-17,19H2,1-2H3,(H2,29,30,31,35)/t24-/m0/s1
  • InChiKey: HBSHKGUGUSSKJW-DEOSSOPVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0125 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0381 0.0435
Onchocerca volvulus 0.0034 0.0125 0.0235
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0029 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0381 0.0848
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0191 0.0494
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0078 0.0071
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0481 0.1669
Brugia malayi Fibulin-1 precursor 0.0016 0.0022 0.0058
Mycobacterium tuberculosis Conserved protein 0.0078 0.0381 0.1313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.016 0.1678
Echinococcus granulosus intermediate filament protein 0.0028 0.0094 0.0087
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0109 0.0282
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0079 0.0084
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0006
Schistosoma mansoni ran 0.0045 0.0191 0.0214
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0021 0.0055
Plasmodium vivax vivapain-2 0.0017 0.0029 0.0058
Loa Loa (eye worm) hypothetical protein 0.0176 0.0952 0.2457
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0321
Onchocerca volvulus 0.0772 0.4417 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0034 0.0089
Leishmania major importin beta-1 subunit, putative 0.005 0.0218 0.2293
Loa Loa (eye worm) beta-lactamase 0.0078 0.0381 0.0984
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0176 0.0952 1
Brugia malayi Pre-SET motif family protein 0.0098 0.0498 0.1286
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0109 0.1146
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.0467 0.4908
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.0952 1
Echinococcus granulosus ring and YY1 binding protein 0.0176 0.0952 0.0945
Trichomonas vaginalis importin beta-1, putative 0.005 0.0218 0.0478
Onchocerca volvulus 0.0021 0.0049 0.006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0049 0.0126
Onchocerca volvulus 0.0017 0.0029 0.0015
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0019
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0381 0.0848
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0495 0.2804 1
Entamoeba histolytica hypothetical protein 0.0073 0.0351 0.0981
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.0467 0.4908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.029 0.0641
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0109 0.1146
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1485 0.1479
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.0467 0.1334
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0049 0.0042
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0183 0.1925
Leishmania major cathepsin L-like protease 0.0017 0.0029 0.0301
Onchocerca volvulus 0.0176 0.0952 0.2115
Leishmania major hypothetical protein, conserved 0.0025 0.0076 0.0803
Brugia malayi brahma associated protein 60 kDa 0.0495 0.2804 0.7242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0012 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0013
Schistosoma mansoni zinc finger protein 0.0016 0.0023 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0176 0.0952 1
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0351 0.04
Loa Loa (eye worm) ctsf protein 0.0017 0.0029 0.0074
Brugia malayi hypothetical protein 0.0144 0.0768 0.1984
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.036
Mycobacterium ulcerans hypothetical protein 0.0078 0.0381 0.2409
Loa Loa (eye worm) hypothetical protein 0.033 0.1846 0.4767
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0381 0.1313
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0012 0.0131
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0191 0.0184
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0022 0.0035
Loa Loa (eye worm) transcription factor SMAD2 0.0378 0.2129 0.5498
Brugia malayi intermediate filament protein 0.0028 0.0094 0.0242
Echinococcus multilocularis microtubule associated protein 2 0.1491 0.8599 0.8598
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.3314 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.016 0.0346
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0381 0.1313
Schistosoma mansoni egf-like domain protein 0.0016 0.0022 0.0018
Trypanosoma brucei ISWI complex protein 0.0016 0.0023 0.0245
Onchocerca volvulus 0.0078 0.0381 0.0817
Loa Loa (eye worm) hypothetical protein 0.0053 0.0237 0.0612
Echinococcus granulosus smad 0.0026 0.0078 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0049 0.0126
Brugia malayi MH1 domain containing protein 0.0026 0.0078 0.0203
Onchocerca volvulus 0.0495 0.2804 0.6331
Loa Loa (eye worm) hypothetical protein 0.0047 0.0204 0.0527
Plasmodium vivax importin-beta 2, putative 0.0061 0.0286 0.0979
Loa Loa (eye worm) hypothetical protein 0.0041 0.0166 0.0429
Leishmania major hypothetical protein, conserved 0.0078 0.0381 0.4006
Schistosoma mansoni smad1 5 8 and 0.0026 0.0078 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.0498 0.0571
Loa Loa (eye worm) hypothetical protein 0.0176 0.0952 0.2457
Trichomonas vaginalis set domain proteins, putative 0.0772 0.4417 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0052
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0042 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0019
Trichomonas vaginalis ran, putative 0.0045 0.0191 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0052
Brugia malayi Bromodomain containing protein 0.0041 0.0166 0.0428
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.013 0.0418
Brugia malayi Thioredoxin reductase 0.0042 0.0171 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0049 0.0126
Onchocerca volvulus 0.0253 0.1403 0.3141
Schistosoma mansoni ap endonuclease 0.004 0.016 0.0177
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0357 0.3755
Brugia malayi MH2 domain containing protein 0.0026 0.0078 0.0203
Toxoplasma gondii ran binding protein 0.0176 0.0952 0.3363
Echinococcus multilocularis dnaJ subfamily B 0.0482 0.2733 0.2727
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0022 0.0058
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0495 0.2804 1
Schistosoma mansoni importin beta-1 0.0061 0.0286 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.0231
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0034 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0381 0.2409
Schistosoma mansoni cellular tumor antigen P53 0.0253 0.1403 0.1624
Loa Loa (eye worm) fibroinase 0.0017 0.0029 0.0074
Echinococcus granulosus dnaJ subfamily B 0.0482 0.2733 0.2727
Leishmania major cathepsin L-like protease 0.0066 0.031 0.326
Echinococcus granulosus Smad4 0.0026 0.0078 0.0071
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0176 0.0952 0.0945
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0049 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0049 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0237 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0049 0.0048
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0467 0.1206
Echinococcus multilocularis cysteine protease 0.0017 0.0029 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0168 0.0903 0.2332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.003 0.0319
Entamoeba histolytica hypothetical protein 0.005 0.0218 0.0577
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0029 0.0015
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0381 0.0984
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0034 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.025 0.0551
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0058
Trypanosoma brucei trypanothione reductase 0.0042 0.0171 0.1795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0049 0.0126
Echinococcus granulosus zinc finger protein Ran binding 0.0176 0.0952 0.0945
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0078
Trypanosoma brucei hypothetical protein, conserved 0.0176 0.0952 1
Echinococcus granulosus lamin 0.0028 0.0094 0.0087
Brugia malayi latrophilin 2 splice variant baaae 0.0115 0.0595 0.1535
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0321
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0034 0.0027
Onchocerca volvulus 0.0078 0.0381 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0049 0.0042
Schistosoma mansoni coup transcription factor 0.0021 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.016 0.0446
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0109 0.056 0.166
Echinococcus multilocularis snurportin 1 0.0656 0.3742 0.3738
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1033 0.1027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0357 0.0793
Onchocerca volvulus 0.0017 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Onchocerca volvulus Huntingtin homolog 0.0144 0.0768 0.1698
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0076 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0029 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0678 0.3873 1
Schistosoma mansoni survival motor neuron protein 0.0055 0.0246 0.0278
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0065 0.0307 0.1057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0168 0.0903 0.2332
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0058
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0109 0.056 0.1254
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0381 0.1313
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.048
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0029 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0049 0.0126
Brugia malayi Smad1 0.0026 0.0078 0.0203
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0078 0.0071
Echinococcus granulosus serine protein kinase ATM 0.0018 0.003 0.0023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.016 0.0399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0049 0.0042
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0495 0.2804 1
Mycobacterium tuberculosis Conserved protein 0.0078 0.0381 0.1313
Schistosoma mansoni zinc finger protein 0.0176 0.0952 0.1099
Schistosoma mansoni smad 0.0026 0.0078 0.0083
Loa Loa (eye worm) nuclear factor I 0.0014 0.0011 0.0029
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0176 0.0952 1
Echinococcus multilocularis cysteine protease 0.0017 0.0029 0.0021
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0337 0.1162
Onchocerca volvulus Huntingtin homolog 0.0144 0.0768 0.1698
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0034 0.036
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0049 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.0481
Onchocerca volvulus 0.0017 0.0029 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0137 0.013
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0176 0.0952 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0329 0.1134
Plasmodium falciparum glutathione reductase 0.0042 0.0171 0.0567
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0176 0.0952 0.2457
Entamoeba histolytica hypothetical protein 0.0073 0.0351 0.0981
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0012 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1033 0.1027
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0174 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0049 0.0126
Leishmania major cathepsin L-like protease 0.0017 0.0029 0.0301
Entamoeba histolytica Ran family GTPase 0.0045 0.0191 0.0495
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.01 0.0509 0.1314
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0381 0.1313
Brugia malayi steroid hormone receptor 0.0021 0.0049 0.0126
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0367 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0116 0.0604 0.0694
Plasmodium falciparum thioredoxin reductase 0.0042 0.0171 0.0567
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0109 0.1146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0049 0.0048
Brugia malayi nuclear receptor NHR-88 0.0021 0.0049 0.0126
Echinococcus granulosus importin subunit beta 1 0.0061 0.0286 0.0279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0283 0.0731
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0042 0.0171 0.0564
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0171 0.0441
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0381 0.0435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0049 0.0042
Schistosoma mansoni cpg binding protein 0.0038 0.0148 0.0164
Loa Loa (eye worm) hypothetical protein 0.0176 0.0952 0.2457
Echinococcus multilocularis fibrillin 1 0.0016 0.0022 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0498 0.0571
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0237 0.0612
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0495 0.2804 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0351 0.0344
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0029 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0027
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0078 0.0203
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Loa Loa (eye worm) hypothetical protein 0.0116 0.0604 0.1559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0116 0.0604 0.0694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0357 0.0793
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1033 0.2668
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0108
Echinococcus multilocularis musashi 0.0028 0.0094 0.0087
Brugia malayi RNA binding protein 0.0061 0.0283 0.0731
Brugia malayi hypothetical protein 0.0073 0.0351 0.0906
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0381 0.2409
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0029 0.0021
Brugia malayi brahma associated protein 60 kDa 0.0495 0.2804 0.7242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0237 0.0612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0029 0.0058
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0109 0.0119
Entamoeba histolytica protein kinase rad3, putative 0.0018 0.003 0.0005
Entamoeba histolytica hypothetical protein 0.0073 0.0351 0.0981
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0106 0.0543 0.1889
Echinococcus multilocularis lamin 0.0028 0.0094 0.0087
Echinococcus granulosus GPCR family 2 0.0053 0.0237 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Leishmania major cathepsin L-like protease 0.0066 0.031 0.326
Leishmania major hypothetical protein, conserved 0.0016 0.0023 0.0245
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0029
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0357 0.3755
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0191 0.2012
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0157 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0058
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0034 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0029 0.0025
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0157 0.0174
Loa Loa (eye worm) hypothetical protein 0.0075 0.0367 0.0947
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0381 0.1321
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.01 0.0509 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0495 0.2804 0.6343
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.016 0.0524
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0176 0.0952 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0495 0.2804 0.7242
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.01 0.0509 0.5347
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0131
Onchocerca volvulus 0.0098 0.0498 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0388 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0049 0.0126
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0056 0.0146
Echinococcus granulosus cpg binding protein 0.0038 0.0148 0.0141
Schistosoma mansoni hypothetical protein 0.0482 0.2733 0.3172
Loa Loa (eye worm) hypothetical protein 0.0268 0.1485 0.3836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0049 0.0126
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0078 0.0083
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0094 0.0242
Mycobacterium tuberculosis Conserved protein 0.0078 0.0381 0.1313
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0171 0.1795
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Echinococcus granulosus snurportin 1 0.0656 0.3742 0.3738
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.0467 0.046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0034 0.036
Leishmania major hypothetical protein, conserved 0.0176 0.0952 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0049 0.0126
Leishmania major cathepsin L-like protease 0.0017 0.0029 0.0301
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0495 0.2804 0.2799
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0049 0.0042
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0049 0.0126
Echinococcus multilocularis zinc finger protein 0.0023 0.0061 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.016 0.0153
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.016 0.1678
Loa Loa (eye worm) hypothetical protein 0.0144 0.0768 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0247 0.0544
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.0467 0.046
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.031 0.326
Schistosoma mansoni hypothetical protein 0.0495 0.2804 0.3256
Onchocerca volvulus 0.0176 0.0952 0.2115
Brugia malayi nuclear hormone receptor 0.0021 0.0049 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0049 0.0126
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0049 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.01 0.0509 0.5347
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0049 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0378 0.2129 0.5498
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0049 0.0048
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.01 0.0509 0.0502
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0012 0.0131
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0049 0.0048
Brugia malayi glucose-6-phosphate dehydrogenase 0.01 0.0509 0.1314
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0109 0.1146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Mycobacterium ulcerans beta-lactamase 0.0078 0.0381 0.2409
Onchocerca volvulus 0.0017 0.0029 0.0015
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0357 0.0793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Echinococcus multilocularis cpg binding protein 0.0038 0.0148 0.0141
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0176 0.0952 0.2457
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0012 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0029 0.0021
Trypanosoma cruzi WLM domain containing protein, putative 0.0176 0.0952 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0495 0.2804 0.2799
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0049 0.0126
Brugia malayi hypothetical protein 0.0016 0.0024 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1033 0.1194
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.003 0.0023
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0022 0.0058
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0022 0.0035
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0137 0.0355
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0106 0.0543 0.1346
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.0467 0.0535
Plasmodium vivax vivapain-2 0.0017 0.0029 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0049 0.0048
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0022 0.0018
Schistosoma mansoni ap endonuclease 0.004 0.016 0.0177
Brugia malayi Pre-SET motif family protein 0.0678 0.3873 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Schistosoma mansoni hypothetical protein 0.0181 0.0983 0.1136
Plasmodium vivax SET domain protein, putative 0.0098 0.0498 0.1739
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0033 0.0121 0.1269
Echinococcus multilocularis smad 0.0026 0.0078 0.0071
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0034 0.0089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.031 0.0303
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0191 0.2012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0049 0.0042
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0106 0.0543 0.1889
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Echinococcus multilocularis GPCR, family 2 0.0053 0.0237 0.023
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0321
Mycobacterium tuberculosis Probable reductase 0.0095 0.0481 0.1669
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.001 0.0003
Echinococcus granulosus microtubule associated protein 2 0.1491 0.8599 0.8598
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.001 0.0003
Giardia lamblia GTOR 0.0093 0.0467 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Onchocerca volvulus 0.0017 0.0029 0.0015
Brugia malayi MH1 domain containing protein 0.0014 0.0011 0.0029
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.0467 0.4908
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0029 0.0074
Onchocerca volvulus 0.0017 0.0029 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0498 0.0491
Toxoplasma gondii thioredoxin reductase 0.0042 0.0171 0.0567
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0286 0.3003
Echinococcus multilocularis ring and YY1 binding protein 0.0176 0.0952 0.0945
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.016 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0076 0.0803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0234
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.003 0.0027
Schistosoma mansoni ran 0.0045 0.0191 0.0214
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0151 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0481 0.1669
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0467 0.1206
Brugia malayi RNA, U transporter 1 0.0175 0.0944 0.2439
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0049 0.006
Toxoplasma gondii cathepsin CPL 0.0017 0.0029 0.0058
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0109 0.056 0.1963
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.01 0.0509 0.5347
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Echinococcus granulosus histone lysine methyltransferase setb 0.0116 0.0604 0.0597
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0012 0.0131
Brugia malayi hypothetical protein 0.0268 0.1485 0.3836
Echinococcus multilocularis geminin 0.0181 0.0983 0.0976
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0012 0.0131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.016 0.1678
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0022 0.0015
Schistosoma mansoni smad1 5 8 and 0.0026 0.0078 0.0083
Chlamydia trachomatis DNA topoisomerase I 0.0495 0.2804 1
Leishmania major trypanothione reductase 0.0042 0.0171 0.1795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0029 0.0049
Brugia malayi hypothetical protein 0.0025 0.0076 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0381 0.4006
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0176 0.0952 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Brugia malayi SWIB/MDM2 domain containing protein 0.0495 0.2804 0.7242
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0381 0.0984
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.016 0.0527
Schistosoma mansoni hypothetical protein 0.0053 0.0237 0.0267
Schistosoma mansoni lamin 0.0028 0.0094 0.0101
Loa Loa (eye worm) glutathione reductase 0.0042 0.0171 0.0441
Brugia malayi isocitrate dehydrogenase 0.0018 0.0034 0.0089
Trichomonas vaginalis esterase, putative 0.0078 0.0381 0.0848
Onchocerca volvulus 0.0028 0.0094 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.0467 0.4908
Brugia malayi MH2 domain containing protein 0.0026 0.0078 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.003 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0049 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0124 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Loa Loa (eye worm) hypothetical protein 0.0115 0.0595 0.1535
Treponema pallidum fructose-bisphosphate aldolase 0.0582 0.3314 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0176 0.0952 0.3363
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0176 0.0952 0.2457
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0049 0.0042
Schistosoma mansoni bromodomain containing protein 0.0069 0.0332 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0079 0.0072
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0034 0.0031
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0012 0.0012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0049 0.0048
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0012 0.0131
Onchocerca volvulus 0.0176 0.0952 0.2115
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0109 0.056 0.1254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0467 0.1043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0351 0.0344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0049 0.0126
Echinococcus multilocularis laminin 0.0016 0.0022 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0381 0.0374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0357 0.0793
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0283 0.0731
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.016 0.0412
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0099
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0109 0.1146
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0286 0.0279
Loa Loa (eye worm) hypothetical protein 0.0253 0.1403 0.3622
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0381 0.1313
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0495 0.2804 0.2799
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 0.0229
Schistosoma mansoni smad1 5 8 and 0.0026 0.0078 0.0083
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 0.0078
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0381 0.0848
Onchocerca volvulus 0.033 0.1846 0.415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0174 0.0167
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0191 0.0542
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0027
Onchocerca volvulus 0.0078 0.0381 0.0817
Schistosoma mansoni hypothetical protein 0.0495 0.2804 0.3256
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.1582 0.5591
Schistosoma mansoni hypothetical protein 0.0055 0.0246 0.0278
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0049 0.0048
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0049 0.006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.3314 1
Brugia malayi MH1 domain containing protein 0.0014 0.0011 0.0029
Brugia malayi MH1 domain containing protein 0.0026 0.0078 0.0203
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.016 0.0153
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0218 0.0478
Schistosoma mansoni cpg binding protein 0.0034 0.0125 0.0138
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0049 0.0048
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.0031
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0012 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0131
Leishmania major cathepsin L-like protease 0.0017 0.0029 0.0301
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0038 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0283 0.0731
Entamoeba histolytica hypothetical protein 0.0073 0.0351 0.0981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.0231
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0065 0.0307 0.1943
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0176 0.0952 0.0945
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0049 0.0042
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Loa Loa (eye worm) hypothetical protein 0.0061 0.0286 0.0738
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0176 0.0952 0.3363
Loa Loa (eye worm) hypothetical protein 0.0144 0.0768 0.1984
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0495 0.2804 1
Echinococcus granulosus laminin 0.0016 0.0022 0.0015
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.003 0.0319
Schistosoma mansoni cpg binding protein 0.0038 0.0148 0.0164
Schistosoma mansoni hypothetical protein 0.0073 0.0351 0.04
Brugia malayi CXXC zinc finger family protein 0.0034 0.0125 0.0324
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0229 0.2402
Entamoeba histolytica hypothetical protein 0.0018 0.003 0.0005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0277 0.2912
Schistosoma mansoni intermediate filament proteins 0.0028 0.0094 0.0101
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Brugia malayi Importin beta-1 subunit 0.0061 0.0286 0.0738
Echinococcus granulosus geminin 0.0181 0.0983 0.0976
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.003 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.004 0.016 0.0346
Echinococcus granulosus cathepsin l1 0.0017 0.0029 0.0021
Loa Loa (eye worm) hypothetical protein 0.0176 0.0952 0.2457
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0237 0.023
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0034 0.036
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0218 0.2293
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0049 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1033 0.1194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0247 0.0544
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0029 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.0952 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0022 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0049 0.0126
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0284
Schistosoma mansoni RNA binding protein 0.0176 0.0952 0.1099
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0109 0.056 0.1254
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0152 0.1599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.025 0.0551
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0191 0.0494
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0109 0.0102
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0283 0.0276
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.016 0.0446
Loa Loa (eye worm) RNA binding protein 0.0061 0.0283 0.0731
Echinococcus granulosus tar DNA binding protein 0.0061 0.0283 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.031 0.326
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.048
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0381 0.0848
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.003 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0034 0.0078
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0109 0.1146
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0078 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Schistosoma mansoni hypothetical protein 0.0053 0.0237 0.0267
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.016 0.1009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1033 0.1027
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0381 0.1313
Toxoplasma gondii exonuclease III APE 0.004 0.016 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.003 0.0052
Brugia malayi hypothetical protein 0.033 0.1846 0.4767
Brugia malayi Calcitonin receptor-like protein seb-1 0.0168 0.0903 0.2332
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0237 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0049 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0058
Brugia malayi PHD-finger family protein 0.0028 0.0094 0.0243
Brugia malayi Bromodomain containing protein 0.0082 0.0404 0.1044
Toxoplasma gondii FATC domain-containing protein 0.0018 0.003 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Brugia malayi beta-lactamase family protein 0.0078 0.0381 0.0984
Plasmodium vivax glutathione reductase, putative 0.0042 0.0171 0.0567
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0029 0.0301
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0017 0.0044
Leishmania major cathepsin L-like protease 0.0066 0.031 0.326
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.031 0.326
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0029 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1033 0.1194
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.0467 0.4908
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0278 0.0614
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0022 0.0058
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0176 0.0952 0.2115
Brugia malayi YY1-associated factor 2 0.0176 0.0952 0.2457
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.1582 1
Brugia malayi FAT domain containing protein 0.0014 0.0007 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.0481 0.0833
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.0803
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0049 0.0042
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0049 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0467 0.1043
Onchocerca volvulus 0.0055 0.0246 0.0509
Echinococcus granulosus Zinc finger RanBP2 type 0.0176 0.0952 0.0945
Echinococcus multilocularis SWI:SNF matrix associated 0.0495 0.2804 0.2799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.025 0.0551
Echinococcus multilocularis Smad4 0.0026 0.0078 0.0071
Schistosoma mansoni Smad4 0.0026 0.0078 0.0083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0012 0.0005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0012 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.0481
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0176 0.0952 0.2457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0049 0.0126
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0078 0.0071
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0191 0.0641
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0137 0.0355
Leishmania major cathepsin L-like protease 0.0017 0.0029 0.0301
Loa Loa (eye worm) cysteine protease 0.0017 0.0029 0.0074
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0018 0.003 0.0005
Schistosoma mansoni hypothetical protein 0.0495 0.2804 0.3256
Echinococcus granulosus zinc finger protein 0.0023 0.0061 0.0054
Leishmania major hypothetical protein, conserved 0.0176 0.0952 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0495 0.2804 0.2799
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0013
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0049 0.0126
Echinococcus granulosus SWI:SNF matrix associated 0.0495 0.2804 0.2799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1033 0.1027
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0049 0.0042
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.01 0.0509 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0109 0.0282
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0022 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0049 0.0126
Onchocerca volvulus 0.0028 0.0094 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0218 0.0478
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0381 0.4006
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0029 0.0021
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0049 0.0126
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0237 0.0612
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.0952 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0582 0.3314 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Schistosoma mansoni TRABID protein (C64 family) 0.0176 0.0952 0.1099
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.0467 0.4908
Echinococcus multilocularis tumor protein p63 0.1732 1 1
Onchocerca volvulus 0.0176 0.0952 0.2115
Loa Loa (eye worm) histone methyltransferase 0.0014 0.001 0.0026
Schistosoma mansoni hypothetical protein 0.0022 0.0056 0.0057
Loa Loa (eye worm) hypothetical protein 0.0176 0.0952 0.2457
Brugia malayi beta-lactamase 0.0078 0.0381 0.0984
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0151 0.0144
Schistosoma mansoni fusion 0.0176 0.0952 0.1099
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0245
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0176 0.0952 0.0945
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.031 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0049 0.0126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0237 0.023
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0176 0.0952 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.0467 0.1334
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0076 0.0229
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0329 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0109 0.0231
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0124 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Brugia malayi TAR-binding protein 0.0061 0.0283 0.0731
Schistosoma mansoni hypothetical protein 0.0176 0.0952 0.1099
Plasmodium vivax hypothetical protein, conserved 0.0495 0.2804 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0034 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0481 0.1669
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0078 0.0203
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0191 0.2012
Echinococcus multilocularis zinc finger protein Ran binding 0.0176 0.0952 0.0945
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0286 0.3003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1033 0.2668
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0094 0.0242
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.016 0.1678
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0029 0.0021
Loa Loa (eye worm) Smad1 0.0026 0.0078 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0498 0.1739
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0656 0.3742 0.9663
Echinococcus granulosus lamin dm0 0.0028 0.0094 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.0803
Onchocerca volvulus 0.0017 0.0029 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0049 0.0126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0049 0.0042
Plasmodium falciparum importin beta, putative 0.0061 0.0286 0.0979
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0381 0.0374
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0246 0.0635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.1582 1
Schistosoma mansoni microtubule-associated protein tau 0.1491 0.8599 1
Leishmania major hypothetical protein, conserved 0.0176 0.0952 1
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0032 0.0115 0.1211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0049 0.0126
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0029 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0029 0.0049
Toxoplasma gondii ABC1 family protein 0.0078 0.0381 0.1321
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.016 0.0527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.031 0.326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0094 0.0242
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0049 0.0048
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0481 0.1669
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0029 0.0021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0191 0.0641
Leishmania major hypothetical protein, conserved 0.0176 0.0952 1
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.01 0.0509 0.1778
Chlamydia trachomatis SWIB complex protein 0.0495 0.2804 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0109 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Echinococcus granulosus Tolloid protein 1 0.0016 0.0022 0.0015
Mycobacterium ulcerans lipase LipD 0.0078 0.0381 0.2409
Trypanosoma cruzi WLM domain containing protein, putative 0.0176 0.0952 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0481 0.1669
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.016 0.0412
Schistosoma mansoni hypothetical protein 0.0053 0.0237 0.0267
Loa Loa (eye worm) hypothetical protein 0.0078 0.0381 0.0984
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0381 0.1313
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0049 0.0048
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0357 0.3755
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.0481
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.01 0.0509 0.0584
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0191 0.0184
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0116 0.0604 0.0597
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0381 0.4006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0008 0.0001
Brugia malayi Cathepsin L-like precursor 0.0017 0.0029 0.0074
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.003 0.0027
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0171 0.0567
Loa Loa (eye worm) brahma associated protein 0.0495 0.2804 0.7242
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0008 0.0001
Schistosoma mansoni hypothetical protein 0.0053 0.0237 0.0267
Brugia malayi ecdysteroid receptor 0.0021 0.0049 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.0242
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0126
Leishmania major hypothetical protein, conserved 0.0176 0.0952 1
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1485 0.1479
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0191 0.0641
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0029 0.0301
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0497 0.2821 1
Schistosoma mansoni hypothetical protein 0.0656 0.3742 0.4347
Schistosoma mansoni zinc finger protein 0.0023 0.0061 0.0063
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0286 0.0979
Leishmania major GTP-binding protein, putative 0.0045 0.0191 0.2012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0049 0.0042
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0109 0.056 0.1963
Schistosoma mansoni lamin 0.0028 0.0094 0.0101
Schistosoma mansoni brg-1 associated factor 0.0495 0.2804 0.3256
Trypanosoma brucei hypothetical protein, conserved 0.0176 0.0952 1
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0109 0.056 0.1963
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.031 0.326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0357 0.0793
Loa Loa (eye worm) hypothetical protein 0.0168 0.0903 0.2332
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.0481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0029 0.0049
Echinococcus multilocularis lamin dm0 0.0028 0.0094 0.0087
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0029 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0137 0.013
Schistosoma mansoni hypothetical protein 0.0115 0.0595 0.0684
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0283 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0219 0.048
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.003 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0467 0.1043
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0381 0.0848
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0094 0.0473 0.0466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0012 0.0131
Brugia malayi beta-lactamase family protein 0.0078 0.0381 0.0984
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.0543 0.1889
Brugia malayi MH2 domain containing protein 0.0378 0.2129 0.5498
Schistosoma mansoni hypothetical protein 0.0181 0.0983 0.1136
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0034 0.0078
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0017 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0042 0.0079
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0079 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0073 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Brugia malayi glutathione reductase 0.0042 0.0171 0.0441
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0049 0.0042
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.01 0.0509 0.1503
Loa Loa (eye worm) hypothetical protein 0.0043 0.0181 0.0467
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0012 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.3314 0.75

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 193 nM Inhibition of human factor 10a ChEMBL. 18644722

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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