Detailed information for compound 1217673

Basic information

Technical information
  • TDR Targets ID: 1217673
  • Name: 2-(4-methoxyphenyl)-1-(4-methylphenyl)sulfony l-3-phenylsulfonylimidazolidine
  • MW: 472.577 | Formula: C23H24N2O5S2
  • H donors: 0 H acceptors: 4 LogP: 3.65 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1N(CCN1S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C23H24N2O5S2/c1-18-8-14-22(15-9-18)32(28,29)25-17-16-24(31(26,27)21-6-4-3-5-7-21)23(25)19-10-12-20(30-2)13-11-19/h3-15,23H,16-17H2,1-2H3
  • InChiKey: UZZCNMKDEIOIIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-1-(4-methylphenyl)sulfonyl-3-phenylsulfonyl-imidazolidine
  • STK212610
  • EU-0041688
  • Oprea1_228242
  • MLS000521400
  • SMR000131808
  • ChemDiv1_023866

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) Smad1 0.0044 0.0048 0.0046
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.0065 0.0063
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.005 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Leishmania major cathepsin L-like protease 0.0036 0.003 0.0394
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.01 0.0098
Schistosoma mansoni chromobox protein 0.0137 0.0249 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.003 0.0025
Mycobacterium ulcerans lipase LipD 0.0035 0.003 0.0238
Loa Loa (eye worm) hypothetical protein 0.0529 0.1092 0.1091
Brugia malayi Cytochrome P450 family protein 0.0095 0.0159 0.0157
Schistosoma mansoni hypothetical protein 0.0095 0.0159 0.0157
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.003 0.0028
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0065 0.0927
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.0041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.0065 0.3196
Schistosoma mansoni cpg binding protein 0.0065 0.0094 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.003 0.0028
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.02 0.2815
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0032 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0039 0.0037
Echinococcus multilocularis tumor protein p63 0.1054 0.2222 0.222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Mycobacterium leprae Probable lipase LipE 0.0035 0.003 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Echinococcus multilocularis expressed protein 0.0374 0.0759 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0018 0.0266
Brugia malayi Importin beta-1 subunit 0.0031 0.002 0.0018
Entamoeba histolytica cysteine protease, putative 0.0036 0.003 0.1422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0015 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0094 0.0092
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.4667 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.005 0.1394
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0108 0.1532
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0038 0.0036
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0045 0.0044
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0002 0.0077
Plasmodium vivax importin-beta 2, putative 0.0031 0.002 0.2835
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.005 0.2413
Echinococcus granulosus beta-adrenergic receptor kinase 0.0032 0.0023 0.0021
Brugia malayi hypothetical protein 0.0135 0.0245 0.0243
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.0042 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0071 0.1174
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0045 0.0043
Loa Loa (eye worm) beta-lactamase 0.0035 0.003 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0201
Echinococcus multilocularis neuropeptide s receptor 0.1902 0.4047 0.4046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0245 0.346
Brugia malayi Smad1 0.0044 0.0048 0.0046
Echinococcus multilocularis cysteine protease 0.0036 0.003 0.0028
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0039 0.0624
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0108 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Schistosoma mansoni kinase 0.0064 0.0092 0.009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.005 0.0674
Plasmodium vivax hypothetical protein, conserved 0.0035 0.003 0.4381
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0022 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0119 0.1999
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0045 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.02 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0059 0.0807
Loa Loa (eye worm) hypothetical protein 0.0206 0.0398 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3318 0.7097 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0039 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0176 0.0174
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.0065 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Brugia malayi hypothetical protein 0.0529 0.1092 0.109
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0043 0.0041
Giardia lamblia Kinase, PLK 0.0114 0.02 1
Echinococcus granulosus peregrin 0.0034 0.0027 0.0025
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.002 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0038 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0045 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0021
Plasmodium vivax vivapain-2 0.0036 0.003 0.4429
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0099 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0008 0.0006
Echinococcus granulosus snurportin 1 0.0329 0.0662 0.066
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.005 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0159 0.0157
Loa Loa (eye worm) hypothetical protein 0.0302 0.0603 0.0601
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.0336 0.0335
Brugia malayi latrophilin 2 splice variant baaae 0.0206 0.0398 0.0396
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.003 0.0025
Echinococcus granulosus smad 0.0044 0.0048 0.0046
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.003 0.0474
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0138 0.0251 0.0249
Schistosoma mansoni hypothetical protein 0.0023 0.0004 0.0002
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0378 0.0768 0.3228
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0004 0.0002
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0039 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0045 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0038 0.0036
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0039 0.1851
Echinococcus multilocularis peregrin 0.0034 0.0027 0.0025
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0048 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0099 0.1377
Schistosoma mansoni inositol monophosphatase 0.0045 0.005 0.0048
Trichomonas vaginalis esterase, putative 0.0035 0.003 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.1078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.0028
Brugia malayi CXXC zinc finger family protein 0.006 0.0082 0.008
Schistosoma mansoni zinc finger protein 0.0025 0.0007 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.003 0.0474
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Onchocerca volvulus 0.0036 0.003 0.0991
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.02 0.0198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.002
Schistosoma mansoni lamin 0.0033 0.0024 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.0344 0.0469
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.0042 0.0571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0045 0.0044
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0099 0.1377
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1647 0.3499 0.3498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0313
Brugia malayi ecdysteroid receptor 0.0043 0.0045 0.0043
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0007 0.0093
Schistosoma mansoni cpg binding protein 0.0065 0.0094 0.0092
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0249 0.4212
Echinococcus multilocularis ferritin 0.0027 0.0012 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0032 0.0023 0.0021
Schistosoma mansoni ap endonuclease 0.0039 0.0038 0.0036
Echinococcus granulosus chromobox protein 1 0.0137 0.0249 0.0247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Onchocerca volvulus 0.0036 0.003 0.0991
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0045 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0159 0.0157
Schistosoma mansoni inositol monophosphatase 0.0045 0.005 0.0048
Echinococcus multilocularis cysteine protease 0.0036 0.003 0.0028
Treponema pallidum replicative DNA helicase (dnaB) 0.0378 0.0768 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.003 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0045 0.0043
Schistosoma mansoni importin beta-1 0.0031 0.002 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0045 0.0043
Onchocerca volvulus 0.0033 0.0024 0.0768
Schistosoma mansoni cellular tumor antigen P53 0.0154 0.0286 0.0284
Loa Loa (eye worm) ctsf protein 0.0036 0.003 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0131 0.0129
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0039 0.1851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0045 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0045 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0045 0.0043
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0099 0.1408
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0005 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0201
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0176 0.0174
Trichomonas vaginalis ran, putative 0.0023 0.0002 0.0008
Brugia malayi RNA, U transporter 1 0.0088 0.0142 0.014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0038 0.0537
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0045 0.0043
Onchocerca volvulus 0.0043 0.0045 0.1527
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0283 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0045 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.0703 1
Echinococcus granulosus chromobox protein 1 0.0137 0.0249 0.0247
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0099 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Brugia malayi jmjC domain containing protein 0.0103 0.0176 0.0174
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.0703 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0099 0.2834
Leishmania major cathepsin L-like protease 0.0135 0.0245 0.346
Onchocerca volvulus 0.0024 0.0005 0.0099
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0028
Schistosoma mansoni Smad4 0.0044 0.0048 0.0046
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0108 0.0106
Echinococcus multilocularis cpg binding protein 0.0065 0.0094 0.0092
Mycobacterium leprae Conserved hypothetical protein 0.1116 0.2355 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0045 0.0043
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0138 0.0251 0.0249
Brugia malayi CHD4 protein 0.0028 0.0014 0.0012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0336 0.0334
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0039 0.0624
Onchocerca volvulus 0.006 0.0083 0.287
Schistosoma mansoni ferritin 0.0027 0.0012 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0038 0.181
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.0159 0.0157
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.005 0.0674
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0045 0.0043
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0059 0.084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0159 0.0157
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0344 0.4395
Trichomonas vaginalis glutaminase, putative 0.0295 0.0588 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.0344 0.0342
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.003 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.4667 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.003 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0045 0.0043
Brugia malayi hypothetical protein 0.0022 0.0002 0.0000092092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0358 0.0356
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0099 0.1377
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0043 0.0041
Mycobacterium ulcerans hypothetical protein 0.0183 0.0348 0.445
Plasmodium falciparum phd finger protein, putative 0.0032 0.0022 0.3104
Onchocerca volvulus Cathepsin F homolog 0.0036 0.003 0.0991
Leishmania major cathepsin L-like protease 0.0036 0.003 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0045 0.0043
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0048 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.01 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0201
Schistosoma mansoni survival motor neuron protein 0.0108 0.0186 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0203
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0036 0.0034
Echinococcus granulosus cpg binding protein 0.0065 0.0094 0.0092
Onchocerca volvulus 0.006 0.0082 0.2818
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.0065 0.3196
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.005 0.0814
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0045 0.0043
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.005 0.0814
Loa Loa (eye worm) hypothetical protein 0.005 0.006 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0344 0.0342
Echinococcus granulosus cathepsin l1 0.0024 0.0005 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0045 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0049 0.08
Plasmodium falciparum importin beta, putative 0.0031 0.002 0.2835
Brugia malayi Heterochromatin protein 1 0.0137 0.0249 0.0247
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Loa Loa (eye worm) fibroinase 0.0036 0.003 0.0028
Schistosoma mansoni cpg binding protein 0.006 0.0082 0.008
Schistosoma mansoni hypothetical protein 0.0138 0.0251 0.0249
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0348 0.0475
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0038 0.0504
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0099 0.4893
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0065 0.0931
Schistosoma mansoni coup transcription factor 0.0043 0.0045 0.0044
Echinococcus multilocularis survival motor neuron protein 1 0.0529 0.1092 0.109
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.02 0.0198
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0108 0.1502
Echinococcus multilocularis dnaJ subfamily B 0.0443 0.0908 0.0906
Loa Loa (eye worm) hypothetical protein 0.0153 0.0283 0.0281
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.0703 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.0344 0.0342
Echinococcus granulosus importin subunit beta 1 0.0031 0.002 0.0018
Brugia malayi Cathepsin L-like precursor 0.0024 0.0005 0.0003
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0106 0.0181 0.2239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0313
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0048 0.0046
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0007 0.0071
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.0249 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0002 0.0014
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Echinococcus granulosus zinc finger protein 0.0025 0.0007 0.0005
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0099 0.1377
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0022
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.02 0.0198
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Echinococcus granulosus tumor protein p63 0.1054 0.2222 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Toxoplasma gondii cathepsin CPL 0.0036 0.003 0.0821
Brugia malayi Bromodomain containing protein 0.0042 0.0043 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0048 0.0046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0045 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0045 0.0044
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0059 0.0807
Treponema pallidum recombinase A 0.0106 0.0181 0.2239
Echinococcus granulosus neuropeptide s receptor 0.1902 0.4047 0.4046
Trypanosoma brucei glucosidase, putative 0.0039 0.0039 0.0549
Onchocerca volvulus 0.0024 0.0005 0.01
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0045 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.003 0.0394
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0022 0.0576
Schistosoma mansoni ran 0.0023 0.0002 0.0001
Schistosoma mansoni smad 0.0044 0.0048 0.0046
Schistosoma mansoni alpha glucosidase 0.0039 0.0039 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0005 0.0049
Onchocerca volvulus 0.0033 0.0024 0.0768
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0031 0.0496
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0099 0.1655
Brugia malayi MH2 domain containing protein 0.0044 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.0077 0.0119 0.0117
Echinococcus multilocularis lamin 0.0033 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0099 0.0097
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0024 0.0303
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.005 0.0501
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0045 0.0044
Onchocerca volvulus Cathepsin L homolog 0.0036 0.003 0.0991
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0014 0.0012
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.0042 0.0604
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Echinococcus multilocularis smad 0.0044 0.0048 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0045 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0245 0.346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0358 0.0356
Leishmania major hypothetical protein, conserved 0.0035 0.003 0.039
Echinococcus multilocularis microtubule associated protein 2 0.1481 0.3141 0.3139
Brugia malayi Muscleblind-like protein 0.0153 0.0283 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0038 0.5639
Schistosoma mansoni ferritin 0.0027 0.0012 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0135 0.0245 0.346
Giardia lamblia GTOR 0.0052 0.0065 0.318
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0302 0.0603 0.0601
Onchocerca volvulus 0.0036 0.003 0.0991
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0045 0.0043
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0048 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0089 0.1484
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0039 0.0624
Echinococcus granulosus muscleblind protein 0.0153 0.0283 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0045 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.0181 0.0343 0.0341
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.003 0.0028
Echinococcus granulosus lamin dm0 0.0033 0.0024 0.0022
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0014 0.0012
Loa Loa (eye worm) glutaminase 2 0.0295 0.0588 0.0586
Leishmania major cathepsin L-like protease 0.0135 0.0245 0.346
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0038 0.0611
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0014 0.0012
Mycobacterium ulcerans hypothetical protein 0.0035 0.003 0.0238
Echinococcus multilocularis Smad4 0.0044 0.0048 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0302 0.0603 0.0601
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0018 0.0266
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Echinococcus granulosus expressed protein 0.0374 0.0759 0.0757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.1078
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.0065 0.0895
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.003 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0203
Schistosoma mansoni hypothetical protein 0.0095 0.0159 0.0157
Brugia malayi intermediate filament protein 0.0033 0.0024 0.0022
Loa Loa (eye worm) cysteine protease 0.0036 0.003 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0443 0.0908 0.0906
Schistosoma mansoni hypothetical protein 0.0032 0.0022 0.002
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.004 0.0119
Echinococcus granulosus microtubule associated protein 2 0.1481 0.3141 0.3139
Leishmania major cysteine peptidase A (CPA) 0.0036 0.003 0.0394
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0038 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0038 0.0036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0038 0.0036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.0065 0.0895
Schistosoma mansoni ap endonuclease 0.0039 0.0038 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.003 0.0028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0045 0.0044
Brugia malayi MH2 domain containing protein 0.0044 0.0048 0.0046
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0002 0.0000092092
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0007 0.0093
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0099 0.0097
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Onchocerca volvulus Alhambra homolog 0.0032 0.0022 0.0695
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.003 0.0028
Loa Loa (eye worm) transcription factor SMAD2 0.0641 0.1334 0.1333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0045 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0132 0.2213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.1078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Brugia malayi MAP kinase sur-1 0.0067 0.0099 0.0097
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0014 0.0012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0202 0.5849
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0031 0.0496
Loa Loa (eye worm) hypothetical protein 0.0077 0.0119 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0203
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0065 0.0899
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.0336 0.0334
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0344 0.4395
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Schistosoma mansoni glutaminase 0.0295 0.0588 0.0586
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Mycobacterium ulcerans glutaminase 0.0295 0.0588 0.762
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.003 0.1422
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.003 0.0028
Mycobacterium tuberculosis Conserved protein 0.0035 0.003 0.0025
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0022 0.002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0483 0.0993 0.0991
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.003 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0005 0.0049
Onchocerca volvulus 0.0036 0.003 0.0991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.0358 0.0356
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0024 0.0303
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0014 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0045 0.0043
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0038 0.179
Trypanosoma cruzi cruzipain precursor, putative 0.0135 0.0245 0.346
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0031 0.0496
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi glutaminase DH11.1 0.0295 0.0588 0.0586
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 0.039
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0108 0.5345
Leishmania major hypothetical protein, conserved 0.0052 0.0065 0.0899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0689
Schistosoma mansoni ferritin light chain 0.0027 0.0012 0.001
Brugia malayi MH1 domain containing protein 0.0024 0.0006 0.0004
Brugia malayi steroid hormone receptor 0.0043 0.0045 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0689
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.003 0.0028
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0002 0.0077
Echinococcus granulosus MAP kinase activated protein kinase 2 0.4667 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0045 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.003 0.0424
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0065 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0082 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0002 0.0000092092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0038 0.0344
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.044 0.0604
Echinococcus multilocularis beta adrenergic receptor kinase 0.0032 0.0023 0.0021
Leishmania major cathepsin L-like protease 0.0036 0.003 0.0394
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0065 0.0063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.0358 0.0356
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0106 0.0181 0.0723
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0378 0.0768 1
Leishmania major cathepsin L-like protease 0.0036 0.003 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0039 0.0515
Schistosoma mansoni hypothetical protein 0.0329 0.0662 0.066
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.0344 1
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0132 0.2213
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0065 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.022 0.3099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0186 0.0184
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0045 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.02 0.2815
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0343 0.0341
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.002 0.0526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0082 0.1137
Brugia malayi Calcitonin receptor-like protein seb-1 0.0302 0.0603 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0065 0.0063
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0039 0.0624
Mycobacterium leprae conserved hypothetical protein 0.0035 0.003 0.0077
Echinococcus granulosus survival motor neuron protein 1 0.0529 0.1092 0.109
Brugia malayi PHD-finger family protein 0.003 0.0019 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.003 0.039
Loa Loa (eye worm) hypothetical protein 0.0095 0.0159 0.0157
Onchocerca volvulus 0.0036 0.003 0.0991
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0159 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0005 0.0003
Schistosoma mansoni smad1 5 8 and 0.0044 0.0048 0.0046
Brugia malayi MH1 domain containing protein 0.0044 0.0048 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0226 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0003
Schistosoma mansoni lamin 0.0033 0.0024 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0045 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0048 0.0046
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.0336 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Loa Loa (eye worm) hypothetical protein 0.006 0.0083 0.0082
Brugia malayi beta-lactamase 0.0035 0.003 0.0028
Onchocerca volvulus Huntingtin homolog 0.0135 0.0245 0.8576
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0099 0.1655
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.0344 0.4878
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0039 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0039 0.0624
Loa Loa (eye worm) hypothetical protein 0.0032 0.0023 0.0021
Loa Loa (eye worm) twinkle helicase 0.0108 0.0186 0.0185
Loa Loa (eye worm) nuclear factor I 0.0024 0.0006 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0007 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0071 0.1174
Echinococcus multilocularis musashi 0.0033 0.0024 0.0022
Echinococcus multilocularis lamin dm0 0.0033 0.0024 0.0022
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0048 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Onchocerca volvulus 0.0035 0.003 0.098
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0048 0.0046
Toxoplasma gondii ABC1 family protein 0.0035 0.003 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.003 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0045 0.0044
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0045 0.0043
Onchocerca volvulus 0.0154 0.0286 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0244
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0039 0.0624
Echinococcus multilocularis expressed protein 0.0027 0.0012 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0045 0.0043
Leishmania major cathepsin L-like protease 0.0036 0.003 0.0394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.0358 0.0356
Mycobacterium tuberculosis Conserved protein 0.0035 0.003 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0045 0.0043
Echinococcus granulosus expressed protein 0.0027 0.0012 0.001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0099 0.1377
Schistosoma mansoni ferritin light chain 0.0027 0.0012 0.001
Brugia malayi hypothetical protein 0.0022 0.0002 0.0000092092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0014 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0045 0.0043
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0054 0.007 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0048 0.0046
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0065 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0119 0.1999
Onchocerca volvulus 0.0036 0.003 0.0991
Schistosoma mansoni hypothetical protein 0.0108 0.0186 0.0184
Brugia malayi follicle stimulating hormone receptor 0.0483 0.0993 0.0991
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0474
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0039 0.0037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0045 0.0044
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.02 0.6971
Onchocerca volvulus Cathepsin L homolog 0.0036 0.003 0.0991
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0039 0.0624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.003 0.048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0159 0.0157
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0065 0.0899
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0119 0.413
Brugia malayi cathepsin L-like precursor 0.0024 0.0005 0.0003
Brugia malayi SET domain containing protein 0.0024 0.0005 0.0003
Schistosoma mansoni Replicative DNA helicase 0.0378 0.0768 0.0767
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0099 0.1655
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0108 0.0106
Chlamydia trachomatis replicative DNA helicase 0.0378 0.0768 1
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0378 0.0768 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0038 0.0344
Brugia malayi MH1 domain containing protein 0.0024 0.0006 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.1902 0.4047 0.4046
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0022 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.003 0.0025
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0038 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0181 0.0343 0.0341
Echinococcus multilocularis chromobox protein 1 0.0137 0.0249 0.0247
Schistosoma mansoni apoferritin-2 0.0027 0.0012 0.001
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Schistosoma mansoni hypothetical protein 0.0095 0.0159 0.0157
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.003 0.0028
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0308 0.4386
Loa Loa (eye worm) hypothetical protein 0.0052 0.0065 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.0358 0.0356
Loa Loa (eye worm) hypothetical protein 0.0044 0.0049 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.003 0.048
Brugia malayi nuclear receptor RXR 0.0022 0.0002 0.0000092092
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0022 0.0576
Schistosoma mansoni chromobox protein 0.0137 0.0249 0.0247
Brugia malayi Inositol-1 0.0045 0.005 0.0048
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.02 0.2815
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0045 0.0043
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0154 0.0286 0.0284
Schistosoma mansoni alpha-glucosidase 0.0153 0.0283 0.0281
Echinococcus multilocularis snurportin 1 0.0329 0.0662 0.066
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0108 0.1502
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.003 0.048
Schistosoma mansoni hypothetical protein 0.0443 0.0908 0.0906
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.0662 0.066
Schistosoma mansoni apoferritin-2 0.0027 0.0012 0.001
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0039 0.1069
Brugia malayi hypothetical protein 0.0052 0.0065 0.0063
Brugia malayi chromobox protein homolog 3 0.0077 0.0119 0.0117
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0099 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Trichomonas vaginalis chromobox protein, putative 0.0137 0.0249 0.4212
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.003 0.4429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0301
Brugia malayi nuclear receptor NHR-88 0.0043 0.0045 0.0043
Echinococcus granulosus lamin 0.0033 0.0024 0.0022
Schistosoma mansoni intermediate filament proteins 0.0033 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0153 0.0283 0.0281
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.002 0.0284
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.003 0.1422
Echinococcus granulosus Smad4 0.0044 0.0048 0.0046
Trichomonas vaginalis ferritin, putative 0.0027 0.0012 0.0167
Onchocerca volvulus 0.0035 0.003 0.098
Brugia malayi Cathepsin L-like precursor 0.0036 0.003 0.0028
Echinococcus multilocularis importin subunit beta 1 0.0031 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.0095 0.0159 0.0157
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0099 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0021
Plasmodium vivax vivapain-2 0.0036 0.003 0.4429
Toxoplasma gondii hypothetical protein 0.0056 0.0075 0.212
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.0344 0.0342
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0474
Schistosoma mansoni ran 0.0023 0.0002 0.0001
Echinococcus granulosus ferritin 0.0027 0.0012 0.001
Loa Loa (eye worm) glutaminase 0.0295 0.0588 0.0586
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0065 0.1855
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.003 0.0028
Mycobacterium tuberculosis Conserved protein 0.0035 0.003 0.0025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0045 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0024 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0045 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.003 0.4429
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0039 0.0515
Brugia malayi PHD-finger family protein 0.0032 0.0022 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0038 0.0611
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0108 0.0106
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.005 0.0707
Echinococcus multilocularis muscleblind protein 0.0153 0.0283 0.0281
Echinococcus granulosus intermediate filament protein 0.0033 0.0024 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0048 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.0703 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0689
Loa Loa (eye worm) inositol-1 0.0045 0.005 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.0358 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0045 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0308 0.4366
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0045 0.1527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0014 0.0012
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0045 0.1527
Giardia lamblia PHD finger protein 15 0.0032 0.0022 0.0974
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.0028
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0037 0.1012
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.002 0.0284
Schistosoma mansoni smad1 5 8 and 0.0044 0.0048 0.0046
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0006 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0045 0.0043
Brugia malayi hypothetical protein 0.0034 0.0026 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.003 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0689
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0002 0.0000092092
Schistosoma mansoni ferritin 0.0027 0.0012 0.001
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0159 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0005 0.0144
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.02 0.0198
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0045 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0022 0.3104
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0024 0.0022
Schistosoma mansoni hypothetical protein 0.0206 0.0398 0.0396
Leishmania major cathepsin L-like protease 0.0135 0.0245 0.346
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0032 0.0023 0.0021
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3046 0.651 0.9171
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0002 0.0001
Schistosoma mansoni alpha-glucosidase 0.0153 0.0283 0.0281
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.0065 0.0927
Mycobacterium ulcerans beta-lactamase 0.0035 0.003 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.003 0.0474
Brugia malayi Cathepsin L-like precursor 0.0024 0.0005 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.0344 0.4395
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0132 0.4573
Brugia malayi Bromodomain containing protein 0.0085 0.0136 0.0134
Toxoplasma gondii exonuclease III APE 0.0039 0.0038 0.1046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0159 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.0358 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0028 0.0452
Echinococcus granulosus cathepsin l1 0.0036 0.003 0.0028
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0048 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0038 0.0504
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0022 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.0065 0.0895
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Echinococcus multilocularis chromobox protein 1 0.0137 0.0249 0.0247
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0038 0.5639
Schistosoma mansoni bromodomain containing protein 0.0072 0.0109 0.0107
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0014 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0039 0.0624
Entamoeba histolytica Ran family GTPase 0.0023 0.0002 0.0025
Brugia malayi nuclear hormone receptor 0.0043 0.0045 0.0043
Mycobacterium ulcerans recombinase A 0.0106 0.0181 0.2239
Brugia malayi MH1 domain containing protein 0.0044 0.0048 0.0046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0038 0.0036
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0099 0.1377
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.005 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.005 0.0814
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0089 0.1484
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.005 0.0674
Schistosoma mansoni ferritin 0.0027 0.0012 0.001
Schistosoma mansoni smad1 5 8 and 0.0044 0.0048 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0042 0.0689
Trypanosoma brucei polo-like protein kinase 0.0114 0.02 0.2841
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0024 0.0022
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.0065 0.0063
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.4667 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.0065 0.0895
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0045 0.0044
Brugia malayi beta-lactamase family protein 0.0035 0.003 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.003 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.0358 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.02 0.3373
Onchocerca volvulus 0.0103 0.0175 0.6099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0026 0.0411
Brugia malayi MH2 domain containing protein 0.0641 0.1334 0.1333
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0099 0.1655
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.003 0.0028
Onchocerca volvulus 0.0035 0.003 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.002 0.0301
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0039 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0045 0.0044
Echinococcus multilocularis GPCR, family 2 0.0095 0.0159 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0038 0.0504
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0308 0.4366
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.1481 0.3141 0.314
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0183 0.257
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.003 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0135 0.0245 0.3483
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0048 0.0046
Brugia malayi jmjC domain containing protein 0.0044 0.0048 0.0046
Leishmania major importin beta-1 subunit, putative 0.0025 0.0007 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0045 0.0044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.003 0.4429
Onchocerca volvulus 0.0108 0.0186 0.6483
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0002 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0045 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.003 0.0028
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.004 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0037 0.0591
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0336 0.0334
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0024 0.0337
Trypanosoma brucei protein kinase, putative 0.0067 0.0099 0.1408
Loa Loa (eye worm) MH2 domain-containing protein 0.0641 0.1334 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0002 0.0000092092
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0108 0.1502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0045 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0045 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0059 0.0807
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.0244
Entamoeba histolytica hypothetical protein 0.0025 0.0007 0.0276
Onchocerca volvulus Huntingtin homolog 0.0135 0.0245 0.8576
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0045 0.1527
Echinococcus granulosus GPCR family 2 0.0095 0.0159 0.0157
Echinococcus multilocularis zinc finger protein 0.0025 0.0007 0.0005
Onchocerca volvulus 0.0036 0.003 0.0991
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.003 0.0238
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0048 0.0046
Brugia malayi Bromodomain containing protein 0.0034 0.0027 0.0025
Echinococcus granulosus neuropeptide receptor A26 0.1902 0.4047 0.4046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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