Detailed information for compound 1265047

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 567.529 | Formula: C26H27F6N7O
  • H donors: 1 H acceptors: 4 LogP: 6.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1nc(ccc1C(F)(F)F)Nc1nc(nc2c1CCN(CC2)c1ncccc1C(F)(F)F)N1CCCCC1
  • InChi: 1S/C26H27F6N7O/c1-40-23-18(26(30,31)32)7-8-20(36-23)35-21-16-9-14-38(22-17(25(27,28)29)6-5-11-33-22)15-10-19(16)34-24(37-21)39-12-3-2-4-13-39/h5-8,11H,2-4,9-10,12-15H2,1H3,(H,34,35,36,37)
  • InChiKey: COKOGXCQUPTSMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References
Rattus norvegicus Vanilloid receptor No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0019 0.0035 0.1413
Loa Loa (eye worm) hypothetical protein 0.0046 0.01 0.0151
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.004 0.0087 0.0122
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0008 0.0008 0.0011
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0018 0.0032 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0342 0.0826 0.5979
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0008 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0023 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0239 0.0614
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0342 0.0826 0.0825
Schistosoma mansoni hypothetical protein 0.0291 0.0699 0.0978
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.0615 0.1588
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0239 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1046 0.2546 0.6592
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0019 0.0035 0.1417
Entamoeba histolytica hypothetical protein 0.0102 0.0239 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Echinococcus granulosus TRP transient receptor potential channel 0.0008 0.0008 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.1127 0.1759
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0342 0.0826 0.0825
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0586 0.1423 0.1422
Leishmania major cathepsin L-like protease 0.0014 0.0023 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0213 0.0509 0.1314
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Brugia malayi MH2 domain containing protein 0.0007 0.0005 0.0009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.0615 0.7442
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0008 0.0008 0.0007
Loa Loa (eye worm) mbt repeat family protein 0.004 0.0087 0.013
Echinococcus granulosus cathepsin l1 0.0014 0.0023 0.0022
Leishmania major importin beta-1 subunit, putative 0.0017 0.0029 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0539 0.1393
Echinococcus granulosus cathepsin l cysteine peptidase 0.0014 0.0023 0.0022
Entamoeba histolytica hypothetical protein 0.1272 0.3099 0.8025
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0014 0.0023 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0054
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.3823
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0213 0.0509 0.0508
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Loa Loa (eye worm) voltage-dependent calcium channel 0.0008 0.0008 0.0006
Echinococcus granulosus microtubule associated protein 2 0.049 0.1187 0.1187
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Loa Loa (eye worm) fatty acid synthase 0.0018 0.0032 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0043 0.0107
Mycobacterium leprae Probable polyketide synthase Pks1 0.0019 0.0035 0.1392
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0232 0.0556 0.0865
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0023 0.0055
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0014 0.002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0018 0.0043
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0102 0.0239 0.0238
Echinococcus multilocularis survival motor neuron protein 1 0.0199 0.0475 0.0474
Echinococcus multilocularis microtubule associated protein 2 0.049 0.1187 0.1187
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.0615 0.1588
Leishmania major phosphatidylinositol kinase, putative 0.0102 0.0239 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.0615 0.0957
Mycobacterium ulcerans polyketide synthase Pks13 0.0027 0.0054 0.2228
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0008 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0102 0.0239 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0239 0.0614
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0094 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.1415 0.3449 0.8931
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0159 0.0376 0.0375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0017 0.0029 0.1155
Echinococcus granulosus short transient receptor potential channel 6 0.0008 0.0008 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0102 0.0239 0.0614
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0005 0.0004
Brugia malayi sulfakinin receptor protein 0.0161 0.0383 0.0987
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0018 0.0032 0.0066
Loa Loa (eye worm) calcium channel 0.0008 0.0008 0.0006
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0046 0.01 0.01
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2928 0.7149 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0019 0.0035 0.1392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0012 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Echinococcus multilocularis Smad4 0.0007 0.0005 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0006 0.0016
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0342 0.0826 0.1155
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0029 0.0071
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0102 0.0239 0.1697
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0008 0.0008 0.0015
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0018 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Loa Loa (eye worm) phosphatidylinositol 3 0.0102 0.0239 0.0368
Loa Loa (eye worm) fibroinase 0.0014 0.0023 0.003
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.0603
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0008 0.0008 0.0007
Echinococcus multilocularis L aminoadipate semialdehyde 0.0059 0.0133 0.0132
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.0615 0.1657
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.1697
Schistosoma mansoni smad1 5 8 and 0.0007 0.0005 0.0007
Giardia lamblia Fructose-bisphosphate aldolase 0.0208 0.0496 0.2565
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Leishmania major cysteine peptidase A (CPA) 0.0014 0.0023 0.0058
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0018 0.0033 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0088 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0008 0.0007
Onchocerca volvulus 0.0014 0.0023 0.0667
Schistosoma mansoni hypothetical protein 0.0041 0.0088 0.0123
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0102 0.0239 0.0614
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0018 0.0032 0.0066
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0043 0.0107
Leishmania major cathepsin L-like protease 0.0014 0.0023 0.0058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0342 0.0826 0.5979
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0008 0.0008 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0003
Loa Loa (eye worm) voltage-gated potassium channel 0.0008 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0007
Schistosoma mansoni transient receptor potential channel 0.0008 0.0008 0.0011
Echinococcus granulosus cysteine protease 0.0007 0.0006 0.0005
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0008 0.0008 0.0015
Toxoplasma gondii cathepsin CPL 0.0014 0.0023 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Echinococcus granulosus voltage gated potassium channel 0.0008 0.0008 0.0007
Echinococcus multilocularis serine protein kinase ATM 0.0225 0.0539 0.0539
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0018 0.0083
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0568 0.1377 0.1926
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0826 0.1288
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0008 0.0011
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0087 0.0122
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0011 0.001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0123 0.0289 0.0733
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0008 0.0011
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0006 0.0004 0.0079
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0024
Brugia malayi hypothetical protein 0.0061 0.0137 0.0352
Schistosoma mansoni hypothetical protein 0.0061 0.0137 0.0192
Echinococcus granulosus cathepsin L cysteine proteinase 0.0014 0.0023 0.0022
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0568 0.1377 0.3563
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.003 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0006 0.0002 0.0001
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0101 0.0237 0.9903
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0025 0.0314
Plasmodium vivax vivapain-2 0.0014 0.0023 0.0275
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0007 0.0007 0.0004
Leishmania major hypothetical protein, conserved 0.1518 0.3699 1
Onchocerca volvulus 0.0014 0.0023 0.0667
Entamoeba histolytica hypothetical protein 0.0102 0.0239 0.0619
Schistosoma mansoni cpg binding protein 0.0022 0.0041 0.0058
Toxoplasma gondii HEAT repeat-containing protein 0.002 0.0039 0.0468
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0008 0.0008 0.0015
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0008 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0094 0.3921
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0015 0.0025 0.0122
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0033 0.13
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1584 0.3861 1
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0054 0.012 0.0295
Treponema pallidum fructose-bisphosphate aldolase 0.0208 0.0496 1
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0032 0.0083
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0018 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.0092
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0036 0.0496
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0094 0.389
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0008 0.0008 0.0015
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0008 0.0008 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0018 0.0032 0.0031
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0014 0.0023 0.003
Echinococcus multilocularis SAM and MBT domain containing protein 0.004 0.0087 0.0086
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0102 0.0239 0.0334
Echinococcus multilocularis transfer RNA-Gly 0.0008 0.0008 0.0007
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Toxoplasma gondii hypothetical protein 0.0008 0.0008 0.0092
Echinococcus granulosus potassium large conductance calcium activated 0.0008 0.0008 0.0007
Entamoeba histolytica Ran family GTPase 0.0015 0.0025 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0014 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0018 0.0033 0.1277
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0008 0.0008 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0102 0.0239 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0008 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.011 0.0259 0.0665
Echinococcus multilocularis importin subunit beta 1 0.002 0.0039 0.0038
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0008 0.0007
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0034 0.0072 0.0182
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0018 0.0033 0.1297
Echinococcus multilocularis two pore calcium channel protein 2 0.0008 0.0008 0.0007
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0017 0.0029 0.0353
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0006 0.0002 0.0012
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0342 0.0826 0.5979
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0008 0.0008 0.0007
Trypanosoma cruzi target of rapamycin kinase 3 0.0342 0.0826 0.2126
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1584 0.3861 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0225 0.0539 0.1383
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0232 0.0556 0.673
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.0025 0.0314
Schistosoma mansoni voltage-dependent calcium channel 0.0008 0.0008 0.0011
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0014 0.0024 0.0933
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0008 0.0008 0.0015
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0008 0.0008 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0061 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0017 0.0029 0.0075
Loa Loa (eye worm) acyl carrier protein 0.0008 0.0009 0.0008
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0017 0.0029 0.0353
Loa Loa (eye worm) transcription factor SMAD2 0.0101 0.0235 0.0362
Onchocerca volvulus 0.0014 0.0023 0.0667
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0005 0.0004
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.0615 0.0614
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0015 0.0025 0.0139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1584 0.3861 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0102 0.0239 0.0368
Brugia malayi Cytochrome P450 family protein 0.001 0.0014 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0239 0.3823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Brugia malayi ion channel NompC 0.0008 0.0008 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0046 0.01 0.01
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0008 0.0008 0.0015
Schistosoma mansoni ran 0.0015 0.0025 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus granulosus calcium activated potassium channel 0.0008 0.0008 0.0007
Echinococcus granulosus SAM and MBT domain containing protein 0.004 0.0087 0.0086
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0032 0.0044
Schistosoma mansoni fkbp-rapamycin associated protein 0.0213 0.0509 0.0712
Echinococcus multilocularis voltage gated potassium channel 0.0008 0.0008 0.0007
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0102 0.0239 0.3823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0232 0.0556 0.1436
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0012 0.0018 0.0664
Loa Loa (eye worm) hypothetical protein 0.0199 0.0475 0.0738
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0017 0.0029 0.0375
Loa Loa (eye worm) phosphatidylinositol 3 0.2616 0.6386 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0219 0.0523 0.0814
Loa Loa (eye worm) hypothetical protein 0.1046 0.2546 0.3983
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0029 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0014 0.0023 0.0055
Brugia malayi MH2 domain containing protein 0.0101 0.0235 0.0604
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.0615 0.1588
Schistosoma mansoni transient receptor potential channel 0.0008 0.0008 0.0011
Echinococcus multilocularis short transient receptor potential channel 6 0.0008 0.0008 0.0007
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0023 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0008 0.0092
Schistosoma mansoni importin beta-1 0.002 0.0039 0.0054
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0008 0.0008 0.0007
Echinococcus granulosus voltage gated hydrogen channel 1 0.0008 0.0008 0.0007
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Entamoeba histolytica hypothetical protein 0.0061 0.0137 0.0356
Onchocerca volvulus Fatty acid synthase homolog 0.0032 0.0068 0.2605
Schistosoma mansoni Smad4 0.0007 0.0005 0.0007
Brugia malayi MH1 domain containing protein 0.0007 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0102 0.0239 0.0334
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0025 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0023 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0006 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0094 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0012 0.0026
Onchocerca volvulus 0.0009 0.0012 0.0173
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.0615 0.1592
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0014 0.002
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0005 0.0002
Brugia malayi hypothetical protein 0.0161 0.0383 0.0987
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1046 0.2546 0.2545
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0159 0.0376 0.0375
Echinococcus multilocularis two pore calcium channel protein 1 0.0008 0.0008 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0235 0.0362
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.0603
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0006 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0017 0.0029 0.1133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0008 0.0092
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0008 0.0008 0.0015
Echinococcus multilocularis short transient receptor potential channel 6 0.0008 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0538 0.1304 0.2036
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0008 0.0008 0.0007
Echinococcus multilocularis ryanodine receptor 44f 0.0008 0.0008 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0005 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0023 0.0032
Plasmodium vivax importin-beta 2, putative 0.002 0.0039 0.0531
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0017 0.0029 0.1155
Toxoplasma gondii type I fatty acid synthase, putative 0.0013 0.002 0.024
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1345 0.3276 0.8485
Leishmania major hypothetical protein, unknown function 0.0008 0.0008 0.0016
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.0615 0.086
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0046 0.01 0.0256
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0008 0.0008 0.0003
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0019 0.0035 0.1413
Toxoplasma gondii hypothetical protein 0.0008 0.0008 0.0092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0025 0.0024
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0102 0.0239 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0023 0.0043
Leishmania major phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.0641
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4094 1 1
Loa Loa (eye worm) MBCTL1 0.0046 0.01 0.0151
Echinococcus granulosus voltage dependent calcium channel 0.0008 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1584 0.3861 1
Echinococcus granulosus hypothetical protein 0.0008 0.0008 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0019 0.0035 0.1413
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.0615 0.0614
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.0025 0.0307
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.0615 0.1592
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Echinococcus multilocularis voltage gated potassium channel 0.0008 0.0008 0.0007
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0102 0.0239 0.0238
Schistosoma mansoni voltage-gated ion channel 0.0008 0.0008 0.0011
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0027 0.0054 0.2216
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0049 0.0109 0.0266
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0023 0.003
Echinococcus granulosus geminin 0.012 0.0283 0.0282
Leishmania major cathepsin L-like protease 0.0014 0.0023 0.0058
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0014 0.0016
Entamoeba histolytica cysteine protease, putative 0.0014 0.0023 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0008 0.0008 0.0092
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0568 0.1377 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0342 0.0826 0.2229
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0008 0.0007
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0018 0.0032 0.0187
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0007 0.0006 0.0192
Onchocerca volvulus 0.002 0.0038 0.1331
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0006 0.0009
Giardia lamblia Rrm3p helicase 0.0018 0.0032 0.0156
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0263 0.0406
Mycobacterium ulcerans thioesterase 0.0015 0.0025 0.0987
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0005 0.0004
Echinococcus multilocularis cathepsin L cysteine protease 0.0014 0.0023 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus multilocularis cpg binding protein 0.0022 0.0041 0.004
Brugia malayi Cathepsin L-like cysteine proteinase 0.0009 0.0012 0.0026
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0102 0.0239 0.0619
Plasmodium falciparum importin beta, putative 0.002 0.0039 0.0531
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0008 0.0008 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0006 0.0004 0.0005
Brugia malayi Importin beta-1 subunit 0.002 0.0039 0.0095
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.012 0.0283 0.0396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0008 0.0008 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Echinococcus granulosus shaker cognate 0.0008 0.0008 0.0007
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0102 0.0239 0.0334
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0414 0.1001 0.5184
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0094 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0305 0.0787
Schistosoma mansoni DNA helicase recq5 0.0009 0.0011 0.0015
Echinococcus granulosus polycomb protein SCMH1 0.004 0.0087 0.0086
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0342 0.0826 0.2139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0826 0.2135
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0008 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0568 0.1377 0.3563
Echinococcus multilocularis dnaJ subfamily B 0.0291 0.0699 0.0698
Echinococcus granulosus cathepsin l1 0.0009 0.0012 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0029 0.0071
Echinococcus granulosus cathepsin L cysteine protease 0.0007 0.0006 0.0005
Mycobacterium ulcerans thioesterase TesA 0.0015 0.0025 0.0987
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0033 0.13
Loa Loa (eye worm) ctsf protein 0.0014 0.0023 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Echinococcus multilocularis voltage dependent calcium channel 0.0008 0.0008 0.0007
Leishmania major cathepsin L-like protease 0.0054 0.012 0.032
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0102 0.0239 0.3823
Onchocerca volvulus 0.0031 0.0065 0.2487
Brugia malayi MH2 domain containing protein 0.0007 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0025 0.0061
Echinococcus multilocularis transient receptor potential gamma protein 0.0008 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0102 0.0239 0.0603
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0008 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Brugia malayi voltage-dependent calcium channel 0.0008 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Echinococcus multilocularis cysteine protease 0.0014 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Schistosoma mansoni DNA helicase recq1 0.0009 0.0011 0.0015
Echinococcus granulosus short transient receptor potential channel 6 0.0008 0.0008 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0039 0.0236
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0102 0.0239 0.0238
Schistosoma mansoni smad 0.0007 0.0005 0.0007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0006 0.0009
Brugia malayi Smad1 0.0007 0.0005 0.0009
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0008 0.0007
Giardia lamblia GTOR 0.0342 0.0826 0.4275
Entamoeba histolytica hypothetical protein 0.0017 0.0029 0.0075
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0008 0.0008 0.0007
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0008 0.0008 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Schistosoma mansoni cpg binding protein 0.002 0.0038 0.0054
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0017 0.0029 0.1154
Brugia malayi hypothetical protein 0.0008 0.0008 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0539 0.1393
Echinococcus multilocularis cathepsin L 0.0007 0.0006 0.0005
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0018 0.0032 0.0066
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0017 0.0031 0.1241
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0008 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0025 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0006 0.0016
Loa Loa (eye worm) cysteine protease 0.0014 0.0023 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Onchocerca volvulus 0.0102 0.0239 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Mycobacterium ulcerans polyketide synthase 0.0019 0.0035 0.1417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0011 0.001
Schistosoma mansoni microtubule-associated protein tau 0.049 0.1187 0.1661
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0017 0.0029 0.0587
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Entamoeba histolytica cysteine proteinase 1, putative 0.0007 0.0006 0.0016
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0008 0.0011
Schistosoma mansoni sex comb on midleg homolog 0.004 0.0087 0.0122
Echinococcus granulosus Smad4 0.0007 0.0005 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0014 0.0024 0.0913
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Schistosoma mansoni cpg binding protein 0.0022 0.0041 0.0058
Echinococcus granulosus bloom syndrome protein 0.0022 0.0043 0.0042
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0342 0.0826 0.2229
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Loa Loa (eye worm) voltage-gated calcium channel 0.0008 0.0008 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0018 0.0033 0.1277
Mycobacterium ulcerans fatty acid synthase Fas 0.0006 0.0002 0.0013
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0094 0.0249
Brugia malayi cation channel family protein 0.0008 0.0008 0.0015
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.0025 0.0314
Echinococcus granulosus smad 0.0007 0.0005 0.0004
Echinococcus multilocularis voltage dependent calcium channel 0.0008 0.0008 0.0007
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0017 0.0029 0.0375
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0008 0.0008 0.0015
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Brugia malayi Cytochrome P450 family protein 0.001 0.0014 0.0031
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1584 0.3861 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0342 0.0826 0.2126
Echinococcus granulosus serine protein kinase ATM 0.0225 0.0539 0.0539
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0008 0.0007
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0008 0.0008 0.0007
Brugia malayi AMP-binding enzyme family protein 0.0017 0.003 0.0072
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0123 0.0289 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0342 0.0826 0.0825
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0007 0.0006 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0018 0.0032 0.0045
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0046 0.01 0.01
Leishmania major hypothetical protein, conserved 0.0008 0.0008 0.0016
Brugia malayi Transient-receptor-potential like protein 0.0008 0.0008 0.0015
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.0615 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0342 0.0826 0.2135
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0102 0.0239 0.0238
Echinococcus granulosus dnaJ subfamily B 0.0291 0.0699 0.0698
Entamoeba histolytica cysteine proteinase 2 0.0007 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0465 0.1127 0.2906
Echinococcus granulosus voltage dependent calcium channel 0.0008 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0568 0.1377 0.3556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus multilocularis sodium channel protein 0.0008 0.0008 0.0007
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.0615 0.0614
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.0615 0.0614
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0061 0.0137 0.0137
Schistosoma mansoni ran 0.0015 0.0025 0.0036
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0102 0.0239 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0239 0.0614
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0023 0.0022
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0008 0.0008 0.0007
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Echinococcus multilocularis sodium leak channel non selective protein 0.0008 0.0008 0.0007
Toxoplasma gondii target of rapamycin (TOR), putative 0.0342 0.0826 1
Schistosoma mansoni smad1 5 8 and 0.0007 0.0005 0.0007
Echinococcus multilocularis calcium activated potassium channel 0.0008 0.0008 0.0007
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0018 0.0032 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Leishmania major hypothetical protein, unknown function 0.0102 0.0239 0.0641
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0008 0.0008 0.0015
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0008 0.0008 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0014 0.0023 0.0275
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.013 0.0305 0.0305
Echinococcus granulosus voltage gated potassium channel 0.0008 0.0008 0.0007
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.004 0.0087 0.3427
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0009 0.0011 0.013
Echinococcus granulosus two pore calcium channel protein 2 0.0008 0.0008 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0008 0.0008 0.0007
Leishmania major phosphatidylinositol 3-kinase, putative 0.0342 0.0826 0.2229
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0011 0.001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0008 0.0008 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0102 0.0239 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Brugia malayi CXXC zinc finger family protein 0.002 0.0038 0.0095
Entamoeba histolytica hypothetical protein 0.0061 0.0137 0.0356
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0008 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Loa Loa (eye worm) CYP4Cod1 0.001 0.0014 0.0016
Loa Loa (eye worm) voltage-gated potassium channel 0.0008 0.0008 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0007 0.0006 0.0012
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0102 0.0239 0.3823
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1106 0.2692 0.6971
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0023 0.006
Echinococcus granulosus survival motor neuron protein 1 0.0199 0.0475 0.0474
Echinococcus granulosus importin subunit beta 1 0.002 0.0039 0.0038
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0029 0.0071
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0008 0.0008 0.0007
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0008 0.0007
Onchocerca volvulus 0.0041 0.0088 0.3464
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0225 0.0539 0.0755
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0208 0.0496 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1481 0.3611 0.9352
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0094 0.3921
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0342 0.0826 0.2229
Brugia malayi Cathepsin L-like precursor 0.0009 0.0012 0.0026
Onchocerca volvulus 0.0014 0.0023 0.0667
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0035 0.0427
Plasmodium vivax hypothetical protein 0.0102 0.0239 0.3823
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1272 0.3099 0.8025
Echinococcus multilocularis shaker cognate 0.0008 0.0008 0.0007
Loa Loa (eye worm) Smad1 0.0007 0.0005 0.0002
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0017 0.0029 0.5
Mycobacterium leprae Polyketide synthase Pks13 0.0027 0.0054 0.2197
Brugia malayi cathepsin L-like precursor 0.0009 0.0012 0.0026
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0342 0.0826 0.1155
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0017 0.0031 0.1241
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0018 0.0033 0.13
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0102 0.0239 0.1697
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0038 0.0054
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0008 0.0008 0.0015
Brugia malayi hypothetical protein 0.0199 0.0475 0.1226
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0006 0.0002 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0213 0.0509 0.1314
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0615 0.1657
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0615 0.1578
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0043 0.0107
Leishmania major cathepsin L-like protease 0.0054 0.012 0.032
Schistosoma mansoni smad1 5 8 and 0.0007 0.0005 0.0007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0008 0.0006
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1584 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Brugia malayi mbt repeat family protein 0.004 0.0087 0.0221
Onchocerca volvulus Cathepsin F homolog 0.0014 0.0023 0.0667
Brugia malayi olfactory channel protein osm-9 0.0008 0.0008 0.0017
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0008 0.0008 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0006 0.0004 0.0003
Brugia malayi Cathepsin L-like precursor 0.0009 0.0012 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.012 0.0295
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Schistosoma mansoni methyltransferase-related 0.0005 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.013 0.0305 0.0427
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0342 0.0826 0.2229
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0025 0.005
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0342 0.0826 0.2139
Leishmania major phosphatidylinositol kinase related protein, putative 0.0115 0.0269 0.0723
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0008 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.012 0.0283 0.0396
Schistosoma mansoni cathepsin F (C01 family) 0.0009 0.0012 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.012 0.0295
Loa Loa (eye worm) hypothetical protein 0.0213 0.0509 0.0791
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0014 0.0024 0.0933
Echinococcus multilocularis polycomb protein SCMH1 0.004 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0007 0.0006 0.0012
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.001 0.0014 0.0496
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0008 0.0092
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0018 0.0033 0.1297
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0008 0.0008 0.0003
Onchocerca volvulus 0.0017 0.003 0.0952
Schistosoma mansoni voltage-gated cation channel 0.0008 0.0008 0.0011
Echinococcus multilocularis smad 0.0007 0.0005 0.0004
Plasmodium vivax vivapain-2 0.0014 0.0023 0.0275
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.0615 0.1588
Onchocerca volvulus 0.0102 0.0239 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0094 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Schistosoma mansoni myelin transcription factor 1 myt1 0.0046 0.01 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0102 0.0239 0.0614
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0208 0.0496 0.1285
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.003 0.1175
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Onchocerca volvulus 0.004 0.0087 0.3427
Leishmania major phosphopantetheinyl transferase-like protein 0.0017 0.0029 0.0074
Echinococcus multilocularis histone acetyltransferase MYST2 0.0046 0.01 0.01
Loa Loa (eye worm) phosphatidylinositol 3 0.0102 0.0239 0.0368
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0011 0.0078
Mycobacterium ulcerans Type I modular polyketide synthase 0.0018 0.0033 0.13
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2928 0.7149 0.7148
Leishmania major cathepsin L-like protease 0.0054 0.012 0.032
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0213 0.0509 0.1318
Onchocerca volvulus 0.0059 0.0133 0.542
Loa Loa (eye worm) ryanodine receptor 0.0008 0.0008 0.0006
Loa Loa (eye worm) ion channel NompC 0.0008 0.0008 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0008 0.0008 0.0011
Onchocerca volvulus 0.0014 0.0023 0.0667
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0342 0.0826 0.2126
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0213 0.0509 0.0508
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.2928 0.7149 0.7148
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Loa Loa (eye worm) RecQ helicase 0.0022 0.0043 0.0061
Schistosoma mansoni two-pore calcium channel 0.0008 0.0008 0.0011
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0008 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0008 0.0008 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0029 0.0167
Schistosoma mansoni vesicular amine transporter 0.0008 0.0008 0.0011
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0019 0.0035 0.1417
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0008 0.0008 0.0015
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0008 0.0007
Leishmania major cathepsin L-like protease 0.0014 0.0023 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.0239 0.2892
Loa Loa (eye worm) hypothetical protein 0.0059 0.0133 0.0202
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0012 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0007 0.0006 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Echinococcus granulosus cathepsin L 0.0007 0.0006 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0568 0.1377 0.3563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0023 0.0667
Echinococcus granulosus L aminoadipate semialdehyde 0.0059 0.0133 0.0132
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0008 0.0015
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Onchocerca volvulus 0.0014 0.0023 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0059 0.0133 0.0186
Toxoplasma gondii transporter, cation channel family protein 0.0008 0.0008 0.0092
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0342 0.0826 0.5979
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0115 0.0269 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Brugia malayi cation channel family protein 0.0008 0.0008 0.0015
Entamoeba histolytica protein kinase rad3, putative 0.0213 0.0509 0.1318
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.001 0.0014 0.0504
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0342 0.0826 0.5979
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0043 0.0042
Entamoeba histolytica hypothetical protein 0.0225 0.0539 0.1397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0232 0.0556 0.4009
Schistosoma mansoni calcium-activated potassium channel 0.0008 0.0008 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Schistosoma mansoni transient receptor potential channel 4 0.0008 0.0008 0.0011
Loa Loa (eye worm) phosphatidylinositol kinase 0.0102 0.0239 0.0368
Brugia malayi RNA, U transporter 1 0.0058 0.0131 0.0335
Leishmania major GTP-binding protein, putative 0.0015 0.0025 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Echinococcus granulosus snurportin 1 0.0219 0.0523 0.0522
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.0039 0.0236
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0008 0.0008 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1106 0.2692 0.6971
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.012 0.0295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0134
Echinococcus multilocularis geminin 0.012 0.0283 0.0282
Entamoeba histolytica hypothetical protein 0.0061 0.0137 0.0356
Entamoeba histolytica hypothetical protein 0.0102 0.0239 0.0619
Trypanosoma brucei cytochrome P450, putative 0.001 0.0014 0.0055
Echinococcus granulosus transient receptor potential cation channel 0.0008 0.0008 0.0007
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0225 0.0539 0.3889
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.0239 0.2892
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0008 0.0008 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0342 0.0826 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Echinococcus multilocularis snurportin 1 0.0219 0.0523 0.0522
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.0615 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0342 0.0826 0.1288
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0008 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0342 0.0826 0.2126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.003
Onchocerca volvulus 0.0014 0.0023 0.0667
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0794 0.193 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0102 0.0239 0.0334
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Echinococcus granulosus cpg binding protein 0.0022 0.0041 0.004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0342 0.0826 0.2126
Schistosoma mansoni hypothetical protein 0.0245 0.0586 0.082
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0005 0.0007
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0018 0.0032 0.0081
Echinococcus granulosus transient receptor potential gamma protein 0.0008 0.0008 0.0007
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0008 0.0007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0025 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0232 0.0556 0.1436
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0008 0.0011
Schistosoma mansoni ryanodine receptor related 0.0008 0.0008 0.0011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0059 0.0133 0.034
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0017 0.0029 0.5
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0008 0.0008 0.0015
Echinococcus granulosus sodium channel protein 0.0008 0.0008 0.0007
Schistosoma mansoni 60S ribosomal protein L21 0.0008 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0032 0.0078
Entamoeba histolytica DNA repair and recombination protein, putative 0.0018 0.0032 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0007 0.0006 0.0012
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0102 0.0239 0.2892
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0008 0.0011
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Brugia malayi Cathepsin L-like precursor 0.0014 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Schistosoma mansoni survival motor neuron protein 0.0041 0.0088 0.0123
Brugia malayi MH1 domain containing protein 0.0007 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.0061 0.0137 0.0356
Echinococcus multilocularis cysteine protease 0.0014 0.0023 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.011 0.0259 0.0665
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0101 0.0237 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0102 0.0239 0.0614
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0213 0.0509 0.1304
Schistosoma mansoni hypothetical protein 0.0219 0.0523 0.0732
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0014 0.0023 0.0275
Leishmania major cathepsin L-like protease 0.0014 0.0023 0.0058
Mycobacterium ulcerans polyketide synthase 0.0018 0.0033 0.13
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0008 0.0008 0.0007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0014 0.0023 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0734 0.1784 0.4619
Echinococcus granulosus sodium leak channel non selective protein 0.0008 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0568 0.1377 0.3563
Schistosoma mansoni transcription factor LCR-F1 0.0061 0.0137 0.0192
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0102 0.0239 0.3823
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0008 0.0007
Brugia malayi FAT domain containing protein 0.013 0.0305 0.0787
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0012 0.0017 0.0207
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Giardia lamblia Phosphatidylinositol 4-kinase 0.0102 0.0239 0.123
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0568 0.1377 0.3566
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0568 0.1377 0.3566
Giardia lamblia Hypothetical protein 0.0102 0.0239 0.123
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0015 0.0025 0.0966
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0005 0.0004
Mycobacterium tuberculosis Probable thioesterase TesA 0.0015 0.0025 0.0988
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0008 0.0008 0.0007
Echinococcus granulosus two pore calcium channel protein 1 0.0008 0.0008 0.0007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1584 0.3861 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 0.012 0.083
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0094 0.0132
Schistosoma mansoni hypothetical protein 0.0008 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0012 0.0018 0.0646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0023 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.0615 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0008 0.0011
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.013 0.0305 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0025 0.0302
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0094 0.3921
Loa Loa (eye worm) hypothetical protein 0.0161 0.0383 0.0594
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0008 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0023 0.0032
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Echinococcus granulosus potassium voltage gated channel protein 0.0008 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.013 0.0305 0.0472
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0008 0.0011
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1046 0.2546 0.2545
Loa Loa (eye worm) hypothetical protein 0.0008 0.0008 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0042 0.0092 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Echinococcus multilocularis potassium large conductance calcium activated 0.0008 0.0008 0.0007
Brugia malayi mbt repeat family protein 0.004 0.0087 0.0221
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0027 0.0054 0.2216
Toxoplasma gondii FATC domain-containing protein 0.0225 0.0539 0.6531
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0008 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0615 0.1578
Echinococcus multilocularis 0.0102 0.0239 0.0238
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.0615 0.4438
Loa Loa (eye worm) phosphatidylinositol 3 0.0102 0.0239 0.0368
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0134
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0008 0.0006
Mycobacterium ulcerans polyketide synthase Pks9 0.0012 0.0018 0.0664
Leishmania major cytochrome p450-like protein 0.001 0.0014 0.0033
Trichomonas vaginalis ran, putative 0.0015 0.0025 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0023 0.0055
Schistosoma mansoni transient receptor potential channel 0.0008 0.0008 0.0012
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0013 0.002 0.0774
Echinococcus granulosus ryanodine receptor 44f 0.0008 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0208 0.0496 0.1281
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0011 0.0024
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0008 0.0008 0.0016
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0094 0.1138
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0018 0.0041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0101 0.0237 0.9903
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0008 0.0007
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0018 0.0033 0.1297
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0008 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0015 0.0025 0.0959
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.0615 0.7442
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0018 0.0032 0.0081
Entamoeba histolytica cysteine protease, putative 0.0007 0.0006 0.0016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0019 0.0035 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0342 0.0826 0.2135
Toxoplasma gondii histone lysine methyltransferase SET1 0.0039 0.0083 0.1006
Echinococcus multilocularis potassium voltage gated channel protein 0.0008 0.0008 0.0007
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0011 0.0048

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 6670 nM Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assay ChEMBL. 20947352
IC50 (binding) > 6670 nM Functional Assay BINDINGDB. No reference
IC50 (binding) > 6670 nM Functional Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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