TDR Targets

Basic information

Technical information

TDR Targets ID: 1318554
Name: 5-[(4-methylphenoxy)methyl]-4-phenyl-2H-1,2,4 -triazole-3-thione
MW: 297.375 | Formula: C16H15N3OS
H donors: 0 H acceptors: 2 LogP: 3.43 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)OCc1nnc(n1c1ccccc1)S
InChi: 1S/C16H15N3OS/c1-12-7-9-14(10-8-12)20-11-15-17-18-16(21)19(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,18,21)
InChiKey: LNWUGGPDGVUHOY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ST5213585
4-Phenyl-5-p-tolyloxymethyl-4H-[1,2,4]triazole-3-thiol
BAS 02070609
MLS000764552
SMR000290157
ZINC00251032

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	RAN, member RAS oncogene family		No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	vitamin D (1,25- dihydroxyvitamin D3) receptor	Starlite/ChEMBL	No references
Homo sapiens	snurportin 1		No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Trypanosoma brucei	hypothetical protein, conserved	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	HpcH/HpaI aldolase/citrate lyase family, putative	Get druggable targets OG5_146801	All targets in OG5_146801
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Leishmania donovani	HpcH/HpaI aldolase/citrate lyase family, putative	Get druggable targets OG5_146801	All targets in OG5_146801
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	steroid hormone receptor	vitamin D (1,25- dihydroxyvitamin D3) receptor	427 aa	416 aa	24.5 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.017
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0039	0.0441	0.0441
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Onchocerca volvulus		0.0076	0.1073	0.2023
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.1073	0.0966
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0114	0.1714	0.1714
Mycobacterium ulcerans	hypothetical protein	0.003	0.0282	0.0818
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Plasmodium vivax	vivapain-3	0.0025	0.0213	0.1249
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0039	0.0441	0.0441
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0441	0.0441
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0114	0.1714	0.1614
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0024	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1105	0.1105
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0039	0.0441	0.0441
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0039	0.0441	0.0326
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0039	0.0441	0.0441
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.1073	0.0966
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0604	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0024	0.0195	0.0195
Leishmania major	cathepsin L-like protease	0.0188	0.2971	0.2886
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0039	0.0441	0.0375
Mycobacterium ulcerans	hypothetical protein	0.0076	0.1073	0.4777
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0055	0.0055
Entamoeba histolytica	hypothetical protein	0.0114	0.1714	0.1614
Trichomonas vaginalis	PIKK family atypical protein kinase	0.048	0.7909	0.7884
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0371	0.0278
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0039	0.0441	0.0441
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0213	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0024	0.0195	0.0195
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0024	0.0195	0.0195
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0402	0.0402
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0039	0.0441	0.0441
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0119	0.0105
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0162	0.2523	0.2433
Brugia malayi	acetyltransferase, GNAT family protein	0.0304	0.4929	0.4929
Schistosoma mansoni	hypothetical protein	0.0033	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0771	0.0771
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0385
Loa Loa (eye worm)	phosphatidylinositol 3	0.0604	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0342	0.0226
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0089	0.1295	0.156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Mycobacterium ulcerans	hypothetical protein	0.003	0.0282	0.0818
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0253	0.0253
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0216	0.0216
Trichomonas vaginalis	PIKK family atypical protein kinase	0.048	0.7909	0.7884
Schistosoma mansoni	hypothetical protein	0.0088	0.1276	0.1276
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.1276	0.1171
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Trichomonas vaginalis	conserved hypothetical protein	0.0075	0.1055	0.0947
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0039	0.0441	0.0441
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0342	0.0342
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0619	0.0619
Brugia malayi	beta-lactamase family protein	0.0076	0.1073	0.1073
Plasmodium vivax	unspecified product	0.0025	0.0213	0.1249
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0037	0.0402	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Schistosoma mansoni	hypothetical protein	0.0033	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0604	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0024	0.0195	0.0195
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.649	0.649
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0024	0.0195	0.0195
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0039	0.0441	0.271
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.1073	0.1021
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0033	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0604	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.0619	0.0564
Onchocerca volvulus		0.0078	0.1105	0.2094
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0024	0.0195	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0023	0.017	0.0256
Loa Loa (eye worm)	ctsf protein	0.0049	0.0619	0.0619
Brugia malayi	steroid hormone receptor	0.0024	0.0195	0.0195
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0039	0.0441	0.0326
Echinococcus multilocularis		0.0039	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0342	0.0342
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0803	0.0803
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0213	0.0155
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.1073	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1552	0.1552
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0024	0.0195	0.0195
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0119	0.0004
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.003	0.0282	0.0165
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0342	0.0226
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0078	0.1105	0.4804
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0619	0.0506
Brugia malayi	Pre-SET motif family protein	0.0037	0.0402	0.0402
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0195	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0604	1	1
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.017	0.0156
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0024	0.0195	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.017	0.0068
Brugia malayi	beta-lactamase	0.0076	0.1073	0.1073
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0055	0.0055
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0202	0.3208	0.3127
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0039	0.0441	0.0441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0342	0.0342
Echinococcus granulosus	cpg binding protein	0.0029	0.028	0.028
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.1073	0.1209
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0023	0.017	0.017
Loa Loa (eye worm)	cysteine protease	0.0049	0.0619	0.0619
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0024	0.0195	0.0195
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.136	0.136
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0023	0.017	0.0256
Echinococcus granulosus	FTZ F1 alpha	0.0024	0.0195	0.0195
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0039	0.0441	0.0385
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.1105	0.4937
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0055	0.0055
Brugia malayi	Steroid receptor seven-up type 2	0.0024	0.0195	0.0195
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0049	0.0619	0.0619
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0213	0.0213
Echinococcus multilocularis	geminin	0.0205	0.3245	0.3245
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0441	0.0441
Mycobacterium ulcerans	hypothetical protein	0.0078	0.1105	0.4937
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0039	0.0441	0.271
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0037	0.0402	0.0402
Entamoeba histolytica	hypothetical protein	0.0035	0.037	0.0254
Entamoeba histolytica	hypothetical protein	0.0039	0.0441	0.0326
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.003	0.0282	0.0165
Schistosoma mansoni	ran	0.0026	0.0216	0.0216
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0202	0.3208	0.3199
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0023	0.017	0.017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0039	0.0441	0.0375
Entamoeba histolytica	hypothetical protein	0.0039	0.0441	0.0326
Leishmania major	hypothetical protein, conserved	0.0039	0.0441	0.0326
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0023	0.017	0.0068
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.1073	0.1209
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0619	0.0619
Entamoeba histolytica	acyl-coA synthetase, putative	0.0078	0.1105	0.0998
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.6074	0.6074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0361	0.5887	0.5838
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0119	0.0119
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0251	0.4026	0.4017
Loa Loa (eye worm)	acetyltransferase	0.0304	0.4929	0.4929
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0216	0.0453
Echinococcus multilocularis	cysteine protease	0.0049	0.0619	0.0619
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0119	0.0119
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.026	0.0142
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.017	0.0256
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0023	0.017	0.0113
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1552	0.1552
Plasmodium vivax	vivapain-1	0.0025	0.0213	0.1249
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0119	0.0119
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0039	0.0441	0.0441
Brugia malayi	MH1 domain containing protein	0.0016	0.0055	0.0055
Onchocerca volvulus	Protein ultraspiracle homolog	0.0024	0.0195	0.0055
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0024	0.0195	0.0195
Onchocerca volvulus	Cathepsin F homolog	0.0049	0.0619	0.1005
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.1073	0.1209
Brugia malayi	MH2 domain containing protein	0.0016	0.0055	0.0055
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0049	0.0619	0.4489
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.3093
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0385
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0058	0.0771	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.063	0.063
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1073	0.0966
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0213	0.0213
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.1073	0.1073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Leishmania major	hypothetical protein, conserved	0.0076	0.1073	0.0966
Plasmodium falciparum	importin beta, putative	0.0035	0.0371	0.201
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0202	0.3208	0.3208
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0213	0.0095
Plasmodium falciparum	acyl-CoA synthetase	0.0058	0.0771	0.6008
Brugia malayi	beta-lactamase family protein	0.0076	0.1073	0.1073
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0039	0.0441	0.0427
Loa Loa (eye worm)	hypothetical protein	0.002	0.0119	0.0119
Onchocerca volvulus		0.0049	0.0619	0.1005
Loa Loa (eye worm)	fibroinase	0.0049	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0771	0.0771
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.017	0.0068
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0717	0.0758
Leishmania major	cathepsin L-like protease	0.0049	0.0619	0.0506
Echinococcus multilocularis	FTZ F1 alpha	0.0024	0.0195	0.0195
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0441	0.0441
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.2971	0.2929
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0023	0.017	0.017
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.136	0.136
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0024	0.0195	0.0195
Onchocerca volvulus		0.0049	0.0619	0.1005
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.037	0.037
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0114	0.1714	0.1714
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0023	0.017	0.0113
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0371	0.0357
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0515	0.8506	0.8488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Mycobacterium tuberculosis	Conserved protein	0.0076	0.1073	0.1209
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0023	0.017	0.0068
Toxoplasma gondii	FATC domain-containing protein	0.0114	0.1714	0.2141
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0039	0.0441	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1864	0.1864
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0441	0.1391
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0342	0.0342
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Entamoeba histolytica	protein kinase rad3, putative	0.0114	0.1714	0.1614
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0481	0.7918	0.7915
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1105	0.1105
Echinococcus granulosus	dna polymerase eta	0.002	0.0119	0.0119
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.3208	0.3208
Schistosoma mansoni	hypothetical protein	0.0372	0.6074	0.6074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0024	0.0195	0.0195
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.017	0.0052
Loa Loa (eye worm)	Smad1	0.0016	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0078	0.1105	0.1249
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0604	1	1
Brugia malayi	MH2 domain containing protein	0.0237	0.3797	0.3797
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0202	0.3208	0.3127
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.1073	0.1073
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0195	0.0195
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0088	0.1276	0.1276
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0039	0.0441	0.0385
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0049	0.0619	0.4489
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Onchocerca volvulus		0.0039	0.0441	0.0607
Schistosoma mansoni	hypothetical protein	0.0396	0.649	0.649
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0119	0.0061
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0202	0.3208	0.3208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Mycobacterium tuberculosis	Conserved protein	0.0076	0.1073	0.1209
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0023	0.017	0.0904
Trypanosoma cruzi	major cysteine proteinase, putative	0.0148	0.2288	0.2243
Schistosoma mansoni	hypothetical protein	0.0033	0.0342	0.0342
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.003	0.0282	0.0818
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.003	0.0282	0.0225
Mycobacterium tuberculosis	Conserved protein	0.0076	0.1073	0.1209
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0089	0.1295	0.156
Echinococcus multilocularis	snurportin 1	0.0372	0.6074	0.6074
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0039	0.0441	0.0441
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.1073	0.106
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.017	0.0113
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0304	0.4929	0.4929
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0342	0.0342
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0342	0.0342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0039	0.0441	0.0326
Echinococcus multilocularis	ecdysone induced protein 78C	0.0024	0.0195	0.0195
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1073	0.0966
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0024	0.0195	0.0195
Brugia malayi	Ets-domain containing protein	0.007	0.0969	0.0969
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.1073	0.1209
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.2971	0.2929
Brugia malayi	RNA, U transporter 1	0.0099	0.1458	0.1458
Brugia malayi	nuclear hormone receptor	0.0024	0.0195	0.0195
Entamoeba histolytica	hypothetical protein	0.0039	0.0441	0.0326
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0119	0.0061
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0717	0.0758
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0089	0.1295	0.1295
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0326	0.5299	0.5243
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0058	0.0058
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0058	0.0058
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0252	0.4046	0.4046
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0216	0.0216
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0039	0.0441	0.0326
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0604	1	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0055	0.0055
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0216	0.0216
Treponema pallidum	fructose-bisphosphate aldolase	0.0282	0.4561	0.5
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0119	0.0119
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Echinococcus granulosus	tumor protein p63	0.0343	0.558	0.558
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0138	0.2116	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0024	0.0195	0.0195
Schistosoma mansoni	cathepsin s	0.0016	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.026	0.0142
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0195	0.0195
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.649	0.649
Onchocerca volvulus		0.0033	0.0342	0.0385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0357	0.5827	0.5777
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0039	0.0441	0.0441
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0402	0.0402
Onchocerca volvulus		0.0049	0.0619	0.1005
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.1073	0.1073
Trypanosoma brucei	unspecified product	0.002	0.0119	0.0105
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Plasmodium vivax	vivapain-2	0.0049	0.0619	0.4529
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0202	0.3208	0.3169
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Echinococcus granulosus	GPCR family 2	0.0033	0.0342	0.0342
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0427
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0119	0.0119
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0039	0.0441	0.0441
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0604	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.037	0.037
Mycobacterium ulcerans	beta-lactamase	0.0076	0.1073	0.4777
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0441	0.3093
Plasmodium vivax	hypothetical protein	0.0039	0.0441	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0039	0.0441	0.0441
Brugia malayi	hypothetical protein	0.0035	0.037	0.037
Onchocerca volvulus		0.0039	0.0441	0.0607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Onchocerca volvulus		0.0076	0.1073	0.2023
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0253	0.0253
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.1055	0.0947
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0075	0.1055	0.1003
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0078	0.1105	0.4937
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0024	0.0195	0.0195
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Entamoeba histolytica	hypothetical protein	0.0035	0.037	0.0254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0039	0.0441	0.0326
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0119	0.0105
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.017	0.017
Leishmania major	hypothetical protein, unknown function	0.0039	0.0441	0.0326
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.003	0.0282	0.021
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.1073	0.4639
Leishmania major	cathepsin L-like protease	0.0049	0.0619	0.0506
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.0213	0.0199
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0037	0.0402	0.0322
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0119	0.0119
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0213	0.0095
Toxoplasma gondii	ABC1 family protein	0.0076	0.1073	0.1252
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.1105	0.4937
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Echinococcus granulosus	cathepsin L cysteine protease	0.0025	0.0213	0.0213
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0326
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.063	0.063
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.003	0.0282	0.0818
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0326
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.0619	0.0619
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0049	0.0619	0.0619
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0604	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0039	0.0441	0.0385
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0119	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0771	0.0771
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.136	0.136
Schistosoma mansoni	coup transcription factor	0.0024	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0023	0.017	0.017
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0326
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0369	0.0369
Echinococcus multilocularis	cysteine protease	0.0049	0.0619	0.0619
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0427
Schistosoma mansoni	DNA polymerase eta	0.002	0.0119	0.0119
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0024	0.0195	0.0195
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0138	0.2116	0.2527
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0039	0.0441	0.0427
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0023	0.017	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Echinococcus multilocularis	tumor protein p63	0.0343	0.558	0.558
Entamoeba histolytica	cysteine proteinase 2	0.0025	0.0213	0.0095
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0402	0.0402
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0195	0.0195
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0039	0.0441	0.0326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0619	0.0506
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Onchocerca volvulus		0.0287	0.4634	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0025	0.0213	0.0155
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0604	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0127	0.1935	0.2447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0202	0.3208	0.3127
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0304	0.4929	0.4929
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.037	0.037
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0823	0.0905
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.136	0.136
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0405	0.6636	0.6595
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0371	0.0371
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0119	0.0119
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0055	0.0055
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0039	0.0441	0.0441
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0039	0.0441	0.0326
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0055	0.0055
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0039	0.0441	0.0326
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0604	1	1
Brugia malayi	MH2 domain containing protein	0.0016	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Trichomonas vaginalis	antibiotic synthetase, putative	0.0023	0.017	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0023	0.017	0.017
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0213	0.0213
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.007	0.0969	0.0969
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0216	0.127
Schistosoma mansoni	Smad4	0.0016	0.0055	0.0055
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0195	0.0195
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0039	0.0441	0.3093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0325	0.5291	0.5234
Loa Loa (eye worm)	beta-lactamase	0.0076	0.1073	0.1073
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0024	0.0195	0.0195
Mycobacterium ulcerans	lipase LipD	0.0076	0.1073	0.4777
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0357	0.5827	0.5777
Loa Loa (eye worm)	hypothetical protein	0.006	0.0797	0.0797
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0039	0.0441	0.0441
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0213	0.0095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0361	0.5887	0.5838
Schistosoma mansoni	gabp alpha	0.007	0.0969	0.0969
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0119	0.0004
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.413	0.4096
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.1105	0.1105
Plasmodium vivax	vivapain-2	0.0049	0.0619	0.4529
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0114	0.1714	0.1702
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.136	0.136
Trypanosoma cruzi	cysteine peptidase, putative	0.0188	0.2971	0.2929
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0119	0.0119
Echinococcus multilocularis	citrate lyase subunit beta protein	0.003	0.0282	0.0282
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1552	0.1552
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1714	0.1714
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.1073	0.1209
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0024	0.0195	0.0055
Schistosoma mansoni	hypothetical protein	0.0072	0.0992	0.0992
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.1105	0.0998
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.003	0.0282	0.0818
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Loa Loa (eye worm)	transcription factor SMAD2	0.0237	0.3797	0.3797
Brugia malayi	Pre-SET motif family protein	0.0252	0.4046	0.4046
Entamoeba histolytica	cysteine proteinase, putative	0.0049	0.0619	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.0342	0.0342
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0481	0.7918	0.7893
Echinococcus multilocularis	serine protein kinase ATM	0.0114	0.1714	0.1714
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0771	0.0771
Schistosoma mansoni	cpg binding protein	0.0029	0.028	0.028
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0078	0.1105	0.4937
Leishmania major	cathepsin L-like protease	0.0188	0.2971	0.2886
Brugia malayi	MH1 domain containing protein	0.0016	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0039	0.0441	0.0326
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.3093
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0172	0.2694	0.2651
Mycobacterium leprae	Probable lipase LipE	0.0076	0.1073	0.4639
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0325	0.5291	0.5234
Entamoeba histolytica	cysteine protease, putative	0.0049	0.0619	0.0506
Trypanosoma cruzi	cysteine proteinase, putative	0.0025	0.0213	0.0155
Brugia malayi	Ets-domain containing protein	0.007	0.0969	0.0969
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0039	0.0441	0.0441
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.017	0.017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0213	0.0095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0326	0.5299	0.5243
Schistosoma mansoni	hypothetical protein	0.0033	0.0342	0.0342
Echinococcus granulosus	serine protein kinase ATM	0.0114	0.1714	0.1714
Trypanosoma cruzi	cruzipain precursor, putative	0.0188	0.2971	0.2929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0326	0.5299	0.5243
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0023	0.017	0.0256
Plasmodium vivax	SET domain protein, putative	0.0037	0.0402	0.2779
Trichomonas vaginalis	set domain proteins, putative	0.0287	0.4634	0.4569
Leishmania major	GTP-binding protein, putative	0.0026	0.0216	0.0098
Brugia malayi	Importin beta-1 subunit	0.0035	0.0371	0.0371
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0216	0.0098
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0024	0.0195	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.048	0.7909	0.7884
Echinococcus granulosus	cathepsin L	0.0025	0.0213	0.0213
Leishmania major	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1552	0.1552
Trichomonas vaginalis	PIKK family atypical protein kinase	0.048	0.7909	0.7884
Schistosoma mansoni	importin beta-1	0.0035	0.0371	0.0371
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0114	0.1714	0.1666
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0114	0.1714	0.1614
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0039	0.0441	0.0375
Entamoeba histolytica	hypothetical protein	0.0039	0.0441	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1276	0.1276
Brugia malayi	Cathepsin L-like precursor	0.0033	0.0342	0.0342
Trichomonas vaginalis	antibiotic synthetase, putative	0.0023	0.017	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0992	0.0992
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0078	0.1105	0.1249
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0023	0.017	0.0068
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0025	0.0213	0.0155
Entamoeba histolytica	hypothetical protein	0.0035	0.037	0.0254
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0119	0.0105
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0024	0.0195	0.0195
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0024	0.0195	0.0195
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0039	0.0441	0.0441
Echinococcus multilocularis	smad	0.0016	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0441	0.0326
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0024	0.0195	0.0195
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.1073	0.1209
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.1105	0.1105
Onchocerca volvulus		0.0049	0.0619	0.1005
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1055	0.1055
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0078	0.1105	0.4937
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.1073	0.4777
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0604	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.017
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0039	0.0441	0.0375
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0216	0.0201
Brugia malayi	ecdysteroid receptor	0.0024	0.0195	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0202	0.3208	0.3127
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0371	0.0371
Onchocerca volvulus		0.0024	0.0195	0.0055
Brugia malayi	FAT domain containing protein	0.0088	0.1276	0.1276
Giardia lamblia	Fructose-bisphosphate aldolase	0.0282	0.4561	0.4495
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0058	0.0771	0.0827
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0049	0.0619	0.0619
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.003	0.0282	0.0225
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0342	0.0342
Schistosoma mansoni	hypothetical protein	0.0205	0.3245	0.3245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0449	0.7382	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0078	0.1105	0.0998
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.1073	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0058	0.0058
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0039	0.0441	0.0385
Onchocerca volvulus	Bile acid receptor homolog	0.0024	0.0195	0.0055
Leishmania major	cathepsin L-like protease	0.0049	0.0619	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.1714	0.1714
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0023	0.017	0.017
Brugia malayi	Fli-1 protein	0.0213	0.3387	0.3387
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.1073	0.8203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.1073	0.4777
Trichomonas vaginalis	ran, putative	0.0026	0.0216	0.0098
Trypanosoma brucei	hypothetical protein, conserved	0.0257	0.413	0.4122
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0024	0.0195	0.0195
Echinococcus multilocularis	cathepsin L	0.0025	0.0213	0.0213
Entamoeba histolytica	acetyltransferase, GNAT family	0.0082	0.1169	0.1063
Echinococcus granulosus	Smad4	0.0016	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.048	0.7909	0.7884
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.017
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0385
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0088	0.1276	0.1276
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0402	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0119	0.0061
Trichomonas vaginalis	esterase, putative	0.0076	0.1073	0.0966
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0216	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0342	0.0342
Leishmania major	cathepsin L-like protease	0.0049	0.0619	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0058	0.0058
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0039	0.0441	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0619	0.0619
Schistosoma mansoni	hypothetical protein	0.0205	0.3245	0.3245
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0049	0.0619	0.4489
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0216	0.0063
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0441	0.0441
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0039	0.0441	0.0326
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0195
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0342	0.0226
Schistosoma mansoni	cpg binding protein	0.0029	0.028	0.028
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Brugia malayi	photoreceptor-specific nuclear receptor	0.0024	0.0195	0.0195
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0023	0.017	0.0052
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.136	0.136
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0342	0.0342
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0023	0.017	0.0156
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0078	0.1105	0.4804
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0717	0.0758
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0202	0.3208	0.3208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0025	0.0213	0.0199
Brugia malayi	Smad1	0.0016	0.0055	0.0055
Echinococcus granulosus	cathepsin l1	0.0049	0.0619	0.0619
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0055	0.0055
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0282	0.4561	0.4495
Onchocerca volvulus		0.005	0.063	0.1031
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0326
Echinococcus granulosus	cathepsin l1	0.0033	0.0342	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0392	0.6415	0.6372
Entamoeba histolytica	Ran family GTPase	0.0026	0.0216	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0024	0.0195	0.0195
Echinococcus multilocularis	Zinc finger, PHD finger	0.0039	0.0441	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0441	0.0326
Loa Loa (eye worm)	oxidoreductase	0.0023	0.017	0.017
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0619	0.1005
Echinococcus granulosus	smad	0.0016	0.0055	0.0055
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0039	0.0441	0.0375
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0138	0.2116	1
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0213	0.0095
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0039	0.0441	0.0441
Echinococcus multilocularis	Smad4	0.0016	0.0055	0.0055
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0371	0.2528
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0039	0.0441	0.0326
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0024	0.0195	0.0195
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0039	0.0441	0.0441
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0195	0.0195
Mycobacterium tuberculosis	Conserved protein	0.003	0.0282	0.021
Giardia lamblia	Hypothetical protein	0.0039	0.0441	0.0326
Schistosoma mansoni	retinoic acid receptor RXR	0.0024	0.0195	0.0195
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0024	0.0195	0.0195
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0023	0.017	0.0256
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.1105	0.1105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0114	0.1714	0.1614
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0195
Giardia lamblia	GTOR	0.0604	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0325	0.5291	0.5234
Trichomonas vaginalis	conserved hypothetical protein	0.0127	0.1935	0.1838
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Loa Loa (eye worm)	fli-1 protein	0.0213	0.3387	0.3387
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0024	0.0195	0.0195
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0342	0.0342
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0024	0.0195	0.0195
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0039	0.0441	0.0326
Echinococcus granulosus	cysteine protease	0.0025	0.0213	0.0213
Loa Loa (eye worm)	steroid hormone receptor	0.0024	0.0195	0.0195
Brugia malayi	cathepsin F-like cysteine proteinase	0.0016	0.0058	0.0058
Schistosoma mansoni	acetyl-CoA synthetase	0.0023	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0441	0.0441
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0213	0.0213
Leishmania major	cathepsin L-like protease	0.0049	0.0619	0.0506
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0449	0.7382	0.735
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Echinococcus granulosus	snurportin 1	0.0372	0.6074	0.6074
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.017	0.0068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0202	0.3208	0.3199
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0992	0.0992
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0078	0.1105	0.0998
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0402	0.0402
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0024	0.0195	0.0195
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0023	0.017	0.0113
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0202	0.3208	0.3208
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0024	0.0195	0.0195
Echinococcus granulosus	geminin	0.0205	0.3245	0.3245
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0114	0.1714	0.1666
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0023	0.017	0.0068
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0441	0.0441
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0361	0.5887	0.5838
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1105	0.1105
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0202	0.3208	0.3169
Brugia malayi	cathepsin L-like precursor	0.0033	0.0342	0.0342
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.1073	0.1073
Leishmania major	hypothetical protein, conserved	0.0257	0.413	0.4059
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.017	0.0068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0326	0.5299	0.5243
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.026	0.0202
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0023	0.017	0.0256
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0025	0.0213	0.0213
Echinococcus granulosus	GA binding protein alpha chain	0.007	0.0969	0.0969
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0049	0.0619	0.0619
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0119	0.0105
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0216	0.0158
Schistosoma mansoni	thyroid hormone receptor	0.0024	0.0195	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0202	0.3208	0.3127
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0016	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0441	0.0441
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0342	0.0342
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0035	0.037	0.037
Plasmodium falciparum	histone acetyltransferase GCN5	0.0082	0.1169	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0024	0.0195	0.0195
Onchocerca volvulus		0.0049	0.0619	0.1005
Schistosoma mansoni	ran	0.0026	0.0216	0.0216
Leishmania major	acetyl-CoA synthetase, putative	0.0023	0.017	0.0052
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0441	0.0441
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.1073	0.0966
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0024	0.0195	0.0195
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0119	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0127	0.1935	0.1935
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0604	1	1
Entamoeba histolytica	hypothetical protein	0.0035	0.037	0.0254
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.136	0.136
Onchocerca volvulus		0.0049	0.0619	0.1005
Schistosoma mansoni	ets-related	0.0213	0.3387	0.3387
Leishmania major	importin beta-1 subunit, putative	0.0028	0.026	0.0142
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0023	0.017	0.0068
Echinococcus multilocularis	cathepsin L cysteine protease	0.0049	0.0619	0.0619
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0023	0.017	0.0256
Onchocerca volvulus		0.0037	0.0402	0.052
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.136	0.136
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0039	0.0441	0.0326
Trypanosoma cruzi	target of rapamycin kinase 3	0.0481	0.7918	0.7905
Echinococcus multilocularis	cpg binding protein	0.0029	0.028	0.028
Trypanosoma cruzi	cysteine protease, putative	0.0025	0.0213	0.0155
Onchocerca volvulus		0.0076	0.1073	0.2023
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0039	0.0441	0.271
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0024	0.0195	0.0195
Schistosoma mansoni	hypothetical protein	0.0039	0.0441	0.0441
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0089	0.1295	0.119
Toxoplasma gondii	cathepsin CPL	0.0049	0.0619	0.0622
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0717	0.0758
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0089	0.1295	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0114	0.1714	0.1714
Leishmania major	cathepsin L-like protease	0.0188	0.2971	0.2886
Leishmania major	acetyl-CoA synthetase, putative	0.0023	0.017	0.0052
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0188	0.2971	0.2961
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0371	0.0371
Echinococcus granulosus	dna polymerase kappa	0.002	0.0119	0.0119
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0023	0.017	0.0256
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0055	0.0055
Entamoeba histolytica	cysteine proteinase 1, putative	0.0025	0.0213	0.0095
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0604	1	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0253	0.0253
Onchocerca volvulus	Cathepsin L homolog	0.0049	0.0619	0.1005
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0049	0.0619	0.0506
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0039	0.0441	0.0441
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.026	0.0142
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.3093
Loa Loa (eye worm)	MH2 domain-containing protein	0.0237	0.3797	0.3797
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.1073	0.1209
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0487	0.8033	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0024	0.0195	0.0195
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.1105	0.0998
Schistosoma mansoni	cathepsin F (C01 family)	0.0049	0.0619	0.0619
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0023	0.017	0.0256
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0039	0.0441	0.0326
Leishmania major	cysteine peptidase A (CPA)	0.0049	0.0619	0.0506
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0025	0.0213	0.0427
Echinococcus granulosus	citrate lyase subunit beta protein	0.003	0.0282	0.0282
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0114	0.1714	0.1614
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0771	0.0771
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0039	0.0441	0.0441
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0039	0.0441	0.0441
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0024	0.0195	0.0195
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.1105	0.0998
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0039	0.0441	0.0385
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0202	0.3208	0.3127
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.017	0.0256
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0039	0.0441	0.0326
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0058	0.0058
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0119	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0202	0.3208	0.3127
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0058	0.0771	0.3262
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.017	0.017
Entamoeba histolytica	hypothetical protein	0.0028	0.026	0.0142
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0023	0.017	0.0068
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.1105	0.4937
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.413	0.4096
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0078	0.1105	0.4937
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0216	0.0216
Giardia lamblia	Histone acetyltransferase GCN5	0.0082	0.1169	0.1063
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0285	0.4614	0.4606
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0039	0.0441	0.0385
Plasmodium vivax	acyl-CoA synthetase, putative	0.0058	0.0771	0.5757
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0604	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0114	0.1714	0.1714
Echinococcus multilocularis	GA binding protein alpha chain	0.007	0.0969	0.0969
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Onchocerca volvulus		0.0028	0.0253	0.0185
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0039	0.0441	0.0326
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0371	0.0357
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0296	0.4785	0.4785
Schistosoma mansoni	smad	0.0016	0.0055	0.0055
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0114	0.1714	0.1714
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0213	0.0095
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0089	0.1295	0.119
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1073	0.1073
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.136	0.136
Onchocerca volvulus		0.0049	0.0619	0.1005
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0039	0.0441	0.0441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0049	0.0619	0.0506
Echinococcus multilocularis	dna polymerase eta	0.002	0.0119	0.0119
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0049	0.0619	0.0619
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0039	0.0441	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0049	0.0619	0.0619
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.1073	0.1073
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0441	0.041
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0049	0.0619	0.0506
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0195	0.0195

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0041 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.0418 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	3.2643 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	4.6109 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	26.8545 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1454602

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1318554