Detailed information for compound 1343641

Basic information

Technical information
  • TDR Targets ID: 1343641
  • Name: N-(6-Ethyl-bicyclo[2.2.1]hept-2-yl)-acetamide
  • MW: 181.275 | Formula: C11H19NO
  • H donors: 1 H acceptors: 1 LogP: 2.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1CC2CC1C(C2)NC(=O)C
  • InChi: 1S/C11H19NO/c1-3-9-4-8-5-10(9)11(6-8)12-7(2)13/h8-11H,3-6H2,1-2H3,(H,12,13)
  • InChiKey: DUPBBXMGYXAPCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000146904
  • MLS000554787

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.005 0.0035 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Toxoplasma gondii heat shock protein HSP90 0.0349 0.0425 0.2391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0031 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0081 0.0222
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0009 0.0009
Echinococcus granulosus acetylcholinesterase 0.0422 0.052 0.052
Brugia malayi follicle stimulating hormone receptor 0.0925 0.1176 0.753
Schistosoma mansoni endoplasmin 0.0349 0.0425 0.0425
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0016 0.0143
Toxoplasma gondii hypothetical protein 0.0055 0.0042 0.019
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0032 0.0203
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0089 0.0656
Schistosoma mansoni nuclear hormone receptor 0.003 0.0009 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0107 0.0109 0.07
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.015 0.0414
Entamoeba histolytica hypothetical protein 0.011 0.0113 0.1025
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0164 0.148
Echinococcus multilocularis acetylcholinesterase 0.0422 0.052 0.052
Plasmodium falciparum thioredoxin reductase 0.0047 0.0032 0.0162
Onchocerca volvulus Cathepsin L homolog 0.005 0.0035 0.038
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0062 0.0051 0.0375
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.005 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0127 0.035
Echinococcus multilocularis cysteine protease 0.005 0.0035 0.0035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Echinococcus granulosus nAChR subunit 0.005 0.0035 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0035 0.0035
Echinococcus multilocularis zinc finger protein 0.0026 0.0004 0.0004
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.0041 0.0265
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0111 0.1003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.0203 0.0203
Echinococcus multilocularis endoplasmin 0.0241 0.0284 0.0284
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0132 0.0132
Echinococcus multilocularis protein dispatched 1 0.0097 0.0097 0.0097
Echinococcus granulosus lamin dm0 0.0079 0.0072 0.0072
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0111 0.1003
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0014 0.0104
Loa Loa (eye worm) hypothetical protein 0.0161 0.018 0.1151
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0009 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0172 0.0172
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0124 0.0131 0.0131
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0081 0.0081
Onchocerca volvulus 0.0251 0.0297 0.3224
Echinococcus granulosus casein kinase i 0.0039 0.0021 0.0021
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0111 0.0586
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0051 0.0051
Mycobacterium ulcerans lipase LipD 0.0149 0.0164 0.045
Onchocerca volvulus 0.0027 0.0005 0.0055
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.0072 0.0463
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0016 0.004
Loa Loa (eye worm) carboxylesterase 0.0071 0.0063 0.0401
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0108 0.0111 0.0263
Plasmodium falciparum heat shock protein 90, putative 0.0124 0.0131 0.0733
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0111 0.0616
Brugia malayi Carboxylesterase family protein 0.0071 0.0063 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0009 0.0058
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0016 0.0044
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0038 0.0242
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.005 0.0035 0.0226
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0054 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0063 0.0063
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0043 0.0043
Onchocerca volvulus 0.0149 0.0164 0.1773
Mycobacterium ulcerans DNA topoisomerase I 0.0089 0.0085 0.0235
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.0164 0.0164
Echinococcus multilocularis Niemann Pick C1 protein 0.0284 0.034 0.034
Loa Loa (eye worm) intermediate filament protein 0.0079 0.0072 0.0463
Brugia malayi casein kinase 1, delta 0.0039 0.0021 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0988 0.1259 0.7133
Loa Loa (eye worm) hypothetical protein 0.0034 0.0013 0.0086
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0013 0.0086
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.005 0.0035 0.0226
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Trichomonas vaginalis heat shock protein, putative 0.0241 0.0284 0.2568
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0108 0.0111 0.0111
Brugia malayi RNA binding protein 0.0062 0.005 0.0322
Mycobacterium tuberculosis Carboxylesterase LipT 0.0071 0.0063 0.0172
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.005 0.0035 0.0226
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0111 0.0817
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0031 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0127 0.0813
Loa Loa (eye worm) hypothetical protein 0.0119 0.0124 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Onchocerca volvulus Putative nachr subunit 0.005 0.0035 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Schistosoma mansoni lipoxygenase 0.0083 0.0078 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0005 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0003 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0089 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus multilocularis tumor protein p63 0.1717 0.2209 0.2209
Onchocerca volvulus 0.0079 0.0072 0.0784
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0127 0.0936
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0035 0.0225
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0016 0.0117
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0014 0.0062
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0071 0.0063 0.0063
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.0347 0.0347
Onchocerca volvulus 0.005 0.0035 0.0383
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0083 0.0749
Onchocerca volvulus 0.0035 0.0016 0.0173
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0035 0.0035
Trypanosoma brucei DNA topoisomerase IA, putative 0.0089 0.0085 0.0629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0081 0.0222
Loa Loa (eye worm) heat shock protein 90 0.0349 0.0425 0.272
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0109 0.0109
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0056 0.0112
Brugia malayi nuclear receptor NHR-88 0.003 0.0009 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0009 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0032 0.0162
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0009 0.0009
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0127 0.035
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.034 0.1748
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0043 0.0273
Schistosoma mansoni survival motor neuron protein 0.0249 0.0294 0.0294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0009 0.0009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0113 0.0113
Echinococcus granulosus para nitrobenzyl esterase 0.0071 0.0063 0.0063
Brugia malayi Probable ClpP-like protease 0.0161 0.018 0.1151
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0041 0.0373
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0087 0.0087
Giardia lamblia Kinase, CMGC CLK 0.0062 0.0051 0.0528
Onchocerca volvulus 0.005 0.0035 0.038
Echinococcus multilocularis peregrin 0.0039 0.0021 0.0021
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.005 0.0035 0.0226
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0111 0.0111
Echinococcus granulosus geminin 0.0502 0.0624 0.0624
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0108 0.0111 0.0305
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0081 0.0519
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.0123
Trichomonas vaginalis heat shock protein, putative 0.0349 0.0425 0.3846
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0203 0.0559
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0035 0.0035
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.005 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0009 0.0058
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0016 0.0143
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.0041 0.0041
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1064 0.1357 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0111 0.0305
Brugia malayi Cytochrome P450 family protein 0.0027 0.0005 0.0035
Onchocerca volvulus Cathepsin F homolog 0.005 0.0035 0.038
Echinococcus multilocularis BC026374 protein (S09 family) 0.0071 0.0063 0.0063
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0108 0.0111 0.0305
Echinococcus multilocularis heat shock protein 0.0349 0.0425 0.0425
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0089 0.0085 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.0164 0.045
Giardia lamblia DNA topoisomerase II 0.0762 0.0963 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0172 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0038 0.0196
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0302 0.0364 0.2328
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0108 0.0111 0.0305
Plasmodium vivax vivapain-2 0.005 0.0035 0.0182
Schistosoma mansoni gliotactin 0.0071 0.0063 0.0063
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0479 0.0594 0.3802
Loa Loa (eye worm) hypothetical protein 0.0121 0.0127 0.0813
Brugia malayi glutathione reductase 0.0047 0.0032 0.0203
Onchocerca volvulus 0.005 0.0035 0.038
Schistosoma mansoni hypothetical protein 0.0047 0.0031 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0164 0.148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0087 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0009 0.0058
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0035 0.0226
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0005 0.004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.005 0.005
Schistosoma mansoni inositol monophosphatase 0.0074 0.0067 0.0067
Schistosoma mansoni protein kinase 0.0039 0.0021 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0041 0.0373
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0089 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.005 0.0035 0.0317
Leishmania major cathepsin L-like protease 0.0191 0.0219 0.1612
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0089 0.0085 0.0547
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0089 0.0085 0.0773
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0009 0.0009
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.015 0.0414
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0031 0.0031
Mycobacterium ulcerans transcriptional regulator 0.2807 0.363 1
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Brugia malayi Pre-SET motif family protein 0.009 0.0088 0.0562
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0035 0.0226
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.0164 0.0164
Echinococcus granulosus endoplasmin 0.0241 0.0284 0.0284
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0781 0.0989 0.7287
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.0041 0.0373
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0121 0.0127 0.035
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0035 0.0225
Schistosoma mansoni tar DNA-binding protein 0.0062 0.005 0.005
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0067 0.0331
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0024 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0087 0.0554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0081 0.0222
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0662 0.0833 0.4741
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0051 0.0461
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0016 0.0117
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0108 0.0111 0.0305
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0067 0.049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0163 0.1041
Leishmania major hypothetical protein, conserved 0.0052 0.0038 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0127 0.0813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Brugia malayi ecdysteroid receptor 0.003 0.0009 0.0058
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.0107 0.0253
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.005 0.0035 0.0226
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0009 0.0009
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0089 0.0085 0.0439
Onchocerca volvulus 0.005 0.0035 0.038
Giardia lamblia Pms1-like protein 0.0108 0.0111 0.115
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Trypanosoma cruzi casein kinase, putative 0.0039 0.0021 0.0152
Onchocerca volvulus 0.0718 0.0906 0.9824
Mycobacterium ulcerans DNA gyrase subunit B 0.0988 0.1259 0.3467
Brugia malayi jmjC domain containing protein 0.0212 0.0246 0.1574
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.332 0.4299 0.4299
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0021 0.0186
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.0164 0.045
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0016 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Chlamydia trachomatis DNA gyrase subunit B 0.0795 0.1006 0.554
Brugia malayi beta-lactamase family protein 0.0149 0.0164 0.1047
Schistosoma mansoni pyruvate dehydrogenase 0.0108 0.0111 0.0111
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0009 0.0009
Plasmodium falciparum DNA gyrase subunit A 0.1364 0.1748 1
Schistosoma mansoni hypothetical protein 0.0502 0.0624 0.0624
Echinococcus granulosus FTZ F1 alpha 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0077 0.0071 0.0452
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0043 0.0043
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0111 0.0817
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.0107 0.0107
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.0107 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0038 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Echinococcus multilocularis cathepsin L 0.0026 0.0003 0.0003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0016 0.0044
Echinococcus granulosus casein kinase I alpha 0.0039 0.0021 0.0021
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0016 0.0117
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0113 0.0113
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.0107 0.0296
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0111 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Plasmodium vivax JmjC domain containing protein 0.0056 0.0043 0.0225
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Echinococcus granulosus lamin 0.0079 0.0072 0.0072
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.087 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Schistosoma mansoni endoplasmin 0.0349 0.0425 0.0425
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0009 0.0009
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0005 0.0035
Entamoeba histolytica heat shock protein 90, putative 0.0349 0.0425 0.3846
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.009 0.0087 0.024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.018 0.0982
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.0203 0.1497
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.0041 0.0304
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0567
Schistosoma mansoni acetylcholinesterase 0.0071 0.0063 0.0063
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0009 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0163 0.1041
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0019 0.0019
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0089 0.0806
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Entamoeba histolytica heat shock protein 90, putative 0.0349 0.0425 0.3846
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0009 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0087 0.0087
Schistosoma mansoni heat shock protein 0.0124 0.0131 0.0131
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0003 0.003
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0419 0.0516 0.1383
Plasmodium vivax DNA topoisomerase II, putative 0.087 0.1104 0.6311
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0043 0.0194
Loa Loa (eye worm) hypothetical protein 0.0069 0.0059 0.0379
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0035 0.0035
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0016 0.0044
Mycobacterium ulcerans two component sensor kinase MprB 0.0108 0.0111 0.0305
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0219 0.1612
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.0107 0.0296
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0016 0.0044
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0042 0.0222
Echinococcus multilocularis lamin 0.0079 0.0072 0.0072
Echinococcus granulosus cathepsin L 0.0026 0.0003 0.0003
Trypanosoma brucei DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Schistosoma mansoni cellular tumor antigen P53 0.0251 0.0297 0.0297
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0043 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0203 0.0559
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.0229 0.1467
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.0203 0.0559
Toxoplasma gondii Hsp90 domain-containing protein 0.0124 0.0131 0.0703
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0009 0.0099
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0021 0.0186
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0272 0.0325 0.0325
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0039 0.0021 0.0132
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0121 0.0127 0.035
Loa Loa (eye worm) hypothetical protein 0.0098 0.0097 0.0624
Loa Loa (eye worm) hypothetical protein 0.0479 0.0594 0.3802
Echinococcus multilocularis heat shock protein 90 0.0349 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0105 0.0106 0.0679
Plasmodium falciparum glutathione reductase 0.0047 0.0032 0.0162
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus multilocularis casein kinase i 0.0039 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0108 0.0111 0.0616
Entamoeba histolytica DNA topoisomerase III, putative 0.0089 0.0085 0.0773
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0108 0.0111 0.0305
Echinococcus multilocularis heat shock protein 90 0.0241 0.0284 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0251 0.0297 0.1904
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.0035 0.0182
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0127 0.0349
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0108 0.0111 0.0305
Onchocerca volvulus 0.0071 0.0063 0.0679
Schistosoma mansoni hypothetical protein 0.0125 0.0132 0.0132
Leishmania major trypanothione reductase 0.0047 0.0032 0.0232
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0013 0.0121
Loa Loa (eye worm) acetylcholinesterase 1 0.0422 0.052 0.3328
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0009 0.0058
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.0164 0.1047
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.005 0.0035 0.0035
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1364 0.1748 0.4815
Schistosoma mansoni jumonji domain containing protein 0.0252 0.0298 0.0298
Echinococcus multilocularis muscleblind protein 0.0302 0.0364 0.0364
Brugia malayi Cytochrome P450 family protein 0.0027 0.0005 0.0035
Brugia malayi steroid hormone receptor 0.003 0.0009 0.0058
Echinococcus multilocularis carboxylesterase 5A 0.0422 0.052 0.052
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0038 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0009 0.0058
Loa Loa (eye worm) hypothetical protein 0.0148 0.0163 0.1041
Plasmodium vivax heat shock protein 86, putative 0.0349 0.0425 0.2416
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0016 0.0016
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0422 0.052 0.3328
Schistosoma mansoni DNA topoisomerase II 0.087 0.1104 0.1104
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0035 0.0035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0009 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0019 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0191 0.0219 0.1612
Trichomonas vaginalis spcc417.12 protein, putative 0.0071 0.0063 0.0566
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.0025 0.0158
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) GABA receptor subunit 0.0027 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Echinococcus multilocularis casein kinase I delta 0.0039 0.0021 0.0021
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0241 0.0284 0.0781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0083 0.0425
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.034 0.3525
Schistosoma mansoni lamin 0.0079 0.0072 0.0072
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0043 0.0043
Leishmania major cathepsin L-like protease 0.005 0.0035 0.0258
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.0041 0.0304
Echinococcus granulosus tar DNA binding protein 0.0062 0.005 0.005
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.0425 0.3131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0163 0.1041
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Echinococcus granulosus transcription factor btf3 0.0034 0.0014 0.0014
Schistosoma mansoni zinc finger protein 0.0026 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0047 0.0031 0.0031
Plasmodium vivax serine/threonine kinase-1, putative 0.0062 0.0051 0.0273
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0108 0.0111 0.1003
Loa Loa (eye worm) hypothetical protein 0.0422 0.052 0.3328
Onchocerca volvulus 0.0034 0.0013 0.0146
Schistosoma mansoni lamin 0.0079 0.0072 0.0072
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Echinococcus granulosus phd:f box containing protein 0.0056 0.0043 0.0043
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0111 0.0305
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0219 0.1612
Echinococcus granulosus zinc finger protein 0.0026 0.0004 0.0004
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.1364 0.1748 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0016 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Toxoplasma gondii casein kinase I 0.0039 0.0021 0.0067
Brugia malayi Cation transporter family protein 0.005 0.0035 0.0226
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0003 0.0024
Giardia lamblia DNA topoisomerase III 0.0089 0.0085 0.0886
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Echinococcus granulosus cathepsin l1 0.0034 0.0013 0.0013
Trypanosoma brucei casein kinase I, isoform 2 0.0039 0.0021 0.0152
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0731 0.0922 1
Brugia malayi Muscleblind-like protein 0.0302 0.0364 0.2328
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Echinococcus granulosus cathepsin l1 0.005 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.0631 0.0793 0.5074
Brugia malayi GRF zinc finger family protein 0.0089 0.0085 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0009 0.0058
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Brugia malayi hypothetical protein 0.011 0.0113 0.0726
Loa Loa (eye worm) ctsf protein 0.005 0.0035 0.0225
Leishmania major developmentally regulated phosphoprotein-like protein 0.0108 0.0111 0.0817
Toxoplasma gondii cathepsin CPL 0.005 0.0035 0.015
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Onchocerca volvulus 0.0149 0.0164 0.1773
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.005 0.0035 0.0035
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2807 0.363 1
Echinococcus multilocularis protein patched 0.0085 0.0081 0.0081
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0016 0.0044
Plasmodium vivax vivapain-2 0.005 0.0035 0.0182
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0019 0.0019
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.363 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0108 0.0111 0.0305
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0051 0.0326
Brugia malayi heat shock protein 90 0.0349 0.0425 0.272
Loa Loa (eye worm) hypothetical protein 0.0121 0.0127 0.0813
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0731 0.0922 1
Brugia malayi Carboxylesterase family protein 0.0071 0.0063 0.0401
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0013 0.0013
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0043 0.0314
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0088 0.0088
Mycobacterium tuberculosis Possible penicillin-binding protein 0.095 0.1208 0.3328
Schistosoma mansoni bromodomain containing protein 0.0068 0.0059 0.0059
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0111 0.0263
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Onchocerca volvulus 0.005 0.0035 0.0383
Mycobacterium leprae conserved hypothetical protein 0.0149 0.0164 0.0409
Echinococcus multilocularis survival motor neuron protein 1 0.1221 0.1562 0.1562
Echinococcus multilocularis geminin 0.0502 0.0624 0.0624
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0053 0.0387
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0003 0.0024
Schistosoma mansoni hypothetical protein 0.0082 0.0077 0.0077
Trichomonas vaginalis set domain proteins, putative 0.0718 0.0906 0.8205
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0089 0.0085 0.0629
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0108 0.0111 0.0153
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0127 0.115
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0124 0.0131 0.1423
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Schistosoma mansoni neurotransmitter gated ion channel 0.0027 0.0005 0.0005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0042 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0212 0.0246 0.1574
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.1364 0.1748 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0071 0.0063 0.0063
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0005 0.004
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0035 0.0035
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0108 0.0111 0.0305
Plasmodium falciparum DNA gyrase subunit B 0.0988 0.1259 0.7195
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0005 0.0033
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.0566 0.0566
Echinococcus multilocularis tar DNA binding protein 0.0062 0.005 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0003 0.003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0016 0.0044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0085 0.0081 0.0519
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0101 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0013 0.0086
Echinococcus multilocularis nAChR subunit 0.005 0.0035 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0081 0.0222
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0042 0.0222
Leishmania major DNA topoisomerase ii 0.0781 0.0989 0.7287
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.038 0.0465 0.298
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0015 0.0015
Brugia malayi kinase, mitochondrial precursor 0.0108 0.0111 0.071
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0032 0.0232
Entamoeba histolytica casein kinase, putative 0.0039 0.0021 0.0186
Onchocerca volvulus 0.0035 0.0016 0.0173
Mycobacterium ulcerans heat shock protein 90 0.0241 0.0284 0.0781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0005 0.0015
Echinococcus granulosus hypothetical protein 0.0061 0.0049 0.0049
Echinococcus granulosus muscleblind protein 0.0302 0.0364 0.0364
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0009 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.7691 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0009 0.0058
Entamoeba histolytica protein kinase, putative 0.0092 0.0089 0.0806
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0067 0.0602
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0035 0.0226
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0016 0.0044
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0161 0.018 0.1011
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.1364 0.1748 1
Leishmania major cathepsin L-like protease 0.0191 0.0219 0.1612
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0003 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0108 0.0111 0.0407
Schistosoma mansoni hypothetical protein 0.0047 0.0031 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0021 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0038 0.0196
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0019 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0 0.0001
Schistosoma mansoni peptidase Clp (S14 family) 0.0161 0.018 0.018
Onchocerca volvulus 0.009 0.0088 0.0951
Mycobacterium tuberculosis Conserved protein 0.0108 0.0111 0.0305
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0041 0.0218
Echinococcus granulosus dual specificity 0.0092 0.0089 0.0089
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.005 0.0035 0.0226
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0043 0.0314
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.015 0.0372
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0067 0.049
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0014 0.0104
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Onchocerca volvulus 0.005 0.0035 0.038
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0016 0.0102
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.021
Schistosoma mansoni heat shock protein 0.0349 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.0047 0.0031 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0149 0.0164 0.0918
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0035 0.0035
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0005 0.0005
Onchocerca volvulus 0.0047 0.0031 0.0332
Leishmania major DNA topoisomerase 1A 0.0089 0.0085 0.0629
Brugia malayi DNA topoisomerase III 0.0089 0.0085 0.0547
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0035 0.0317
Plasmodium vivax hypothetical protein, conserved 0.003 0.0009 0.0032
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0089 0.0085 0.0773
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0005 0.0033
Brugia malayi DNA topoisomerase III beta-1 0.0089 0.0085 0.0547
Loa Loa (eye worm) hypothetical protein 0.0023 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0083 0.0425
Giardia lamblia Kinase, CK1 Casein kinase 0.0039 0.0021 0.0213
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0043 0.0043
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0043 0.0043
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0124 0.0124
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0016 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.0164 0.1205
Schistosoma mansoni ap endonuclease 0.0055 0.0041 0.0041
Onchocerca volvulus 0.0071 0.0063 0.0679
Entamoeba histolytica hypothetical protein 0.011 0.0113 0.1025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0083 0.0749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0035 0.0225
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0108 0.0111 0.0263
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0067 0.0183
Loa Loa (eye worm) ACC-1 protein 0.005 0.0035 0.0226
Entamoeba histolytica hypothetical protein 0.0034 0.0014 0.0128
Trypanosoma brucei heat shock protein 90, putative 0.0349 0.0425 0.3131
Loa Loa (eye worm) hypothetical protein 0.038 0.0465 0.298
Trypanosoma brucei RNA helicase, putative 0.0109 0.0112 0.0821
Brugia malayi Cathepsin L-like precursor 0.0034 0.0013 0.0086
Schistosoma mansoni hypothetical protein 0.0502 0.0624 0.0624
Onchocerca volvulus 0.0079 0.0072 0.0784
Loa Loa (eye worm) fibroinase 0.005 0.0035 0.0225
Echinococcus multilocularis musashi 0.0079 0.0072 0.0072
Brugia malayi Carboxylesterase family protein 0.0071 0.0063 0.0401
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0009 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0102
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0121 0.0127 0.035
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0067 0.0602
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0003 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.7691 1 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0043 0.0043
Leishmania major cytochrome p450-like protein 0.0027 0.0005 0.004
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0108 0.0111 0.0305
Onchocerca volvulus 0.0071 0.0063 0.0679
Leishmania major hypothetical protein, conserved 0.0108 0.0111 0.0817
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0038 0.0276
Brugia malayi Cathepsin L-like precursor 0.0034 0.0013 0.0086
Brugia malayi Protein kinase domain containing protein 0.0092 0.0089 0.0571
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0019 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0014 0.0128
Echinococcus multilocularis GPCR, family 2 0.0047 0.0031 0.0031
Leishmania major cathepsin L-like protease 0.0191 0.0219 0.1612
Mycobacterium tuberculosis Conserved protein 0.0149 0.0164 0.045
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.005 0.0035 0.0035
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.0425 0.3131
Entamoeba histolytica protein kinase, putative 0.0092 0.0089 0.0806
Echinococcus multilocularis casein kinase I delta 0.0039 0.0021 0.0021
Schistosoma mansoni intermediate filament proteins 0.0079 0.0072 0.0072
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.0203 0.1116
Mycobacterium tuberculosis Conserved protein 0.0149 0.0164 0.045
Giardia lamblia Grp94/Hsp90 0.0241 0.0284 0.2945
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0015 0.0015
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0014 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0088 0.0453
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0053 0.0144
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Mycobacterium tuberculosis Possible two component sensor kinase 0.0108 0.0111 0.0305
Brugia malayi Bromodomain containing protein 0.0039 0.0021 0.0136
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0016 0.0044
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0081 0.0081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0009 0.0058
Leishmania major cathepsin L-like protease 0.005 0.0035 0.0258
Schistosoma mansoni BC026374 protein (S09 family) 0.0071 0.0063 0.0063
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0988 0.1259 0.3467
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0087 0.0554
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0117
Leishmania major basic transcription factor 3a, putative 0.0034 0.0014 0.0104
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.0041 0.0114
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0031 0.0197
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0009 0.0009
Giardia lamblia DNA topoisomerase III 0.0089 0.0085 0.0886
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.0425 0.3131
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.0121 0.0127 0.0813
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.1011
Brugia malayi hypothetical protein 0.0052 0.0038 0.024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.0233 0.0233
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.0793 0.5074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.0041 0.0041
Toxoplasma gondii DNA topoisomerase 2, putative 0.087 0.1104 0.6299
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.0566 0.0566
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0016 0.0044
Echinococcus granulosus carboxylesterase 5A 0.0422 0.052 0.052
Brugia malayi jmjC domain containing protein 0.0272 0.0325 0.2078
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Chlamydia trachomatis DNA gyrase subunit A 0.1364 0.1748 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0031 0.0197
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Echinococcus granulosus heat shock protein 0.0349 0.0425 0.0425
Brugia malayi Hsp90 protein 0.0124 0.0131 0.0841
Trypanosoma cruzi casein kinase, putative 0.0039 0.0021 0.0152
Brugia malayi casein kinase I 0.0039 0.0021 0.0132
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0241 0.0284 0.2091
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Plasmodium vivax acyl-CoA synthetase, putative 0.009 0.0087 0.0481
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.0229 0.0229
Brugia malayi Probable DNA topoisomerase II 0.087 0.1104 0.7071
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Plasmodium falciparum DNA topoisomerase 2 0.087 0.1104 0.6311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0051 0.0375
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0014 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0054 0.0054
Trypanosoma cruzi DNA topoisomerase II, putative 0.0781 0.0989 0.7287
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0108 0.0111 0.0305
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0071 0.0063 0.0566
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.0164 0.045
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0019 0.0019
Schistosoma mansoni patched 1 0.0085 0.0081 0.0081
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0003 0.003
Brugia malayi nuclear hormone receptor 0.003 0.0009 0.0058
Trypanosoma cruzi DNA topoisomerase II, putative 0.0781 0.0989 0.7287
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0016 0.0044
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0016 0.0117
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0108 0.0111 0.0305
Loa Loa (eye worm) RNA binding protein 0.0062 0.005 0.0322
Echinococcus granulosus expressed conserved protein 0.0187 0.0213 0.0213
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0164 0.148
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0089 0.0656
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0003 0.0024
Brugia malayi Cytochrome P450 family protein 0.0083 0.0079 0.0503
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0016 0.0072
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0016 0.0143
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.0041 0.0114
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Echinococcus granulosus cysteine protease 0.0026 0.0003 0.0003
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0035 0.0035
Echinococcus granulosus heat shock protein 90 0.0241 0.0284 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0109 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0111 0.0305
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.0197 0.1452
Mycobacterium ulcerans two component regulator - sensor kinase 0.0108 0.0111 0.0305
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0121 0.0127 0.035
Onchocerca volvulus 0.005 0.0035 0.0383
Mycobacterium leprae Probable two component sensor kinase MprB 0.0108 0.0111 0.0263
Plasmodium falciparum phd finger protein, putative 0.003 0.0009 0.0032
Giardia lamblia Heat shock protein HSP 90-alpha 0.0241 0.0284 0.2945
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0016 0.0044
Mycobacterium tuberculosis Probable reductase 0.0108 0.0111 0.0305
Toxoplasma gondii heat shock protein 90, putative 0.0349 0.0425 0.2391
Plasmodium vivax heat shock protein, putative 0.0124 0.0131 0.0733
Brugia malayi Bromodomain containing protein 0.008 0.0074 0.0473
Schistosoma mansoni hypothetical protein 0.0082 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0988 0.1259 0.7133
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0043 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0043 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Loa Loa (eye worm) hypothetical protein 0.0101 0.0102 0.065
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0005 0.0035
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0016 0.0117
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0035 0.0035
Echinococcus granulosus lysine specific demethylase 5A 0.0212 0.0246 0.0246
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.005 0.0035 0.0035
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0035 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0062 0.0051 0.0327
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0016 0.004
Schistosoma mansoni neuroligin 3 (S09 family) 0.0071 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0109 0.0112 0.0112
Entamoeba histolytica acyl-coA synthetase, putative 0.0121 0.0127 0.115
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0009 0.0058
Entamoeba histolytica hypothetical protein 0.011 0.0113 0.1025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0113 0.0113
Echinococcus granulosus Niemann Pick C1 protein 0.0284 0.034 0.034
Mycobacterium ulcerans putative regultory protein 0.0108 0.0111 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0009 0.0058
Schistosoma mansoni inositol monophosphatase 0.0074 0.0067 0.0067
Brugia malayi Protein kinase domain containing protein 0.0062 0.0051 0.0327
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0035 0.0035
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0016 0.0044
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.005 0.0035 0.0226
Toxoplasma gondii heat shock protein 75, putative 0.0124 0.0131 0.0703
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0043 0.0043
Trypanosoma brucei heat shock protein 90, putative 0.0349 0.0425 0.3131
Schistosoma mansoni tar DNA-binding protein 0.0062 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0038 0.024
Trichomonas vaginalis sensor histidine kinase, putative 0.0108 0.0111 0.1003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0009 0.0058
Mycobacterium ulcerans fatty-acid-CoA ligase 0.009 0.0087 0.024
Mycobacterium tuberculosis Probable two component sensor kinase 0.0108 0.0111 0.0305
Echinococcus multilocularis dual specificity protein kinase clk2 0.0062 0.0051 0.0051
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0021 0.0186
Plasmodium vivax heat shock protein 90, putative 0.0124 0.0131 0.0733
Echinococcus granulosus heat shock protein 90 0.0349 0.0425 0.0425
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0108 0.0111 0.0305
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0111 0.0111
Brugia malayi jmjC domain containing protein 0.0056 0.0043 0.0273
Schistosoma mansoni coup transcription factor 0.003 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0164 0.1205
Leishmania major cysteine peptidase A (CPA) 0.005 0.0035 0.0258
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0009 0.0058
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Onchocerca volvulus 0.005 0.0035 0.0383
Schistosoma mansoni jumonji/arid domain-containing protein 0.0212 0.0246 0.0246
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0067 0.0148
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.005 0.0035 0.0035
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0009 0.0026
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0077 0.0071 0.0452
Entamoeba histolytica hypothetical protein 0.0027 0.0005 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0212 0.0246 0.0246
Echinococcus granulosus casein kinase I alpha 0.0039 0.0021 0.0021
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0016 0.0016
Loa Loa (eye worm) ACC-1 protein 0.005 0.0035 0.0226
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0811
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.0072 0.0463
Brugia malayi Thioredoxin reductase 0.0047 0.0032 0.0203
Brugia malayi hypothetical protein 0.1221 0.1562 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0039 0.0021 0.0152
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Brugia malayi DNA topoisomerase II, alpha isozyme 0.087 0.1104 0.7071
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Loa Loa (eye worm) hypothetical protein 0.0077 0.0071 0.0452
Echinococcus granulosus dual specificity protein kinase clk2 0.0062 0.0051 0.0051
Mycobacterium ulcerans beta-lactamase 0.0149 0.0164 0.045
Loa Loa (eye worm) DNA topoisomerase III 0.0089 0.0085 0.0547
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0161 0.018 0.018
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0124 0.0131 0.0131
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.0164 0.045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0111
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0039 0.0021 0.0132
Echinococcus granulosus neuroligin 0.0071 0.0063 0.0063
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0035 0.0035
Echinococcus granulosus acetylcholinesterase 0.0422 0.052 0.052
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0035 0.0035
Onchocerca volvulus 0.0035 0.0016 0.0173
Echinococcus granulosus casein kinase I alpha 0.0039 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0149 0.0164 0.045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.0041 0.0304
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0032 0.0087
Onchocerca volvulus 0.0027 0.0005 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0111 0.0305
Entamoeba histolytica DNA topoisomerase II, putative 0.087 0.1104 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Onchocerca volvulus Cathepsin L homolog 0.005 0.0035 0.038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.0347 0.0347
Onchocerca volvulus 0.005 0.0035 0.0383
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.005 0.0035 0.0226
Echinococcus multilocularis lamin dm0 0.0079 0.0072 0.0072
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.0164 0.045
Loa Loa (eye worm) hypothetical protein 0.0199 0.0229 0.1467
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Loa Loa (eye worm) TAR-binding protein 0.0062 0.005 0.0322
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0495
Onchocerca volvulus 0.005 0.0035 0.038
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0014 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Leishmania major protein kinase, putative 0.0062 0.0051 0.0375
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0053 0.0053
Echinococcus granulosus casein kinase I delta 0.0039 0.0021 0.0021
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0067 0.0067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0009 0.0009
Plasmodium falciparum endoplasmin, putative 0.0232 0.0272 0.1542
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0241 0.0284 0.0284
Echinococcus granulosus neuropeptide s receptor 0.0457 0.0566 0.0566
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0019 0.0137
Brugia malayi Inositol-1 0.0074 0.0067 0.0426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0164 0.0164
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0271 0.0323 0.0849
Toxoplasma gondii DNA topoisomerase family protein 0.0089 0.0085 0.0439
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0108 0.0111 0.0407
Trypanosoma brucei Heat shock protein 83, putative 0.0349 0.0425 0.3131
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0031 0.0197
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0127 0.0936
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0053 0.0144
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0027 0.0005 0.0005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0045 0.0045
Echinococcus granulosus peregrin 0.0039 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Loa Loa (eye worm) inositol-1 0.0074 0.0067 0.0426
Giardia lamblia Heat shock protein HSP 90-alpha 0.0349 0.0425 0.441
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0035 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0009 0.0058
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0731 0.0922 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0062 0.0051 0.0375
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0016 0.0117
Brugia malayi Endoplasmin precursor 0.0349 0.0425 0.272
Plasmodium falciparum protein serine/threonine kinase-1 0.0062 0.0051 0.0273
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0053 0.0053
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0009 0.0009
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0111 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0031 0.0197
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Plasmodium falciparum heat shock protein 90 0.0349 0.0425 0.2416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0024 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0083 0.0083
Echinococcus multilocularis rho GTPase activating protein 20 0.0089 0.0085 0.0085
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.009 0.0087 0.0011
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0089 0.0656
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0043 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0164 0.1205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0067 0.0602
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0016 0.0117
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0009 0.0009
Onchocerca volvulus 0.005 0.0035 0.038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0925 0.1176 0.753
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.0164 0.045
Trypanosoma brucei heat shock protein 84, putative 0.0124 0.0131 0.0967
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0035 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0014 0.0128
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0016 0.0044
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus multilocularis muscleblind protein 1 0.0302 0.0364 0.0364
Plasmodium vivax SET domain protein, putative 0.009 0.0088 0.0483
Trypanosoma cruzi heat shock protein, putative 0.0124 0.0131 0.0967
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0009 0.0009
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0108 0.0111 0.0305
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0014 0.0091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0005 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0051 0.0051
Trypanosoma cruzi heat shock protein 90, putative 0.0225 0.0263 0.194
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0014 0.0128
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0063 0.0172
Loa Loa (eye worm) hypothetical protein 0.0079 0.0072 0.0463
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0083 0.0083
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.0229 0.2074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Treponema pallidum heat shock protein 90 0.0241 0.0284 0.142
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0108 0.0111 0.0305
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0089 0.0085 0.0085
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Echinococcus multilocularis cysteine protease 0.005 0.0035 0.0035
Echinococcus multilocularis 0.0061 0.0049 0.0049
Loa Loa (eye worm) carboxylesterase 0.0071 0.0063 0.0401
Trichomonas vaginalis heat shock protein, putative 0.0232 0.0272 0.2466
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0071 0.0386
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0039 0.0021 0.0132
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Trichomonas vaginalis heat shock protein, putative 0.0241 0.0284 0.2568
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0035 0.0317
Mycobacterium leprae Probable lipase LipE 0.0149 0.0164 0.0409
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.005 0.0035 0.0258
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0014 0.0128
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0071 0.0639
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0009 0.0058
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0021 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0127 0.0936
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Entamoeba histolytica casein kinase 1, putative 0.0039 0.0021 0.0186
Onchocerca volvulus 0.005 0.0035 0.038
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Treponema pallidum DNA topoisomerase I (topA) 0.0089 0.0085 0.0258
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0035 0.0226
Trypanosoma cruzi major cysteine proteinase, putative 0.015 0.0165 0.1219
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0019 0.0168
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0043 0.0194
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0038 0.0019 0.012
Entamoeba histolytica hypothetical protein 0.0092 0.0089 0.0806
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0089 0.0656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Loa Loa (eye worm) cysteine protease 0.005 0.0035 0.0225
Schistosoma mansoni ap endonuclease 0.0055 0.0041 0.0041
Trypanosoma brucei developmentally regulated phosphoprotein 0.0108 0.0111 0.0817
Entamoeba histolytica DNA topoisomerase III, putative 0.0089 0.0085 0.0773
Brugia malayi Cation transporter family protein 0.005 0.0035 0.0226
Loa Loa (eye worm) oxidoreductase 0.0035 0.0016 0.0102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0053 0.0144
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0067 0.049
Loa Loa (eye worm) hypothetical protein 0.0108 0.0111 0.071
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0241 0.0284 0.0741
Loa Loa (eye worm) hypothetical protein 0.1221 0.1562 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0203 0.0559
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0016 0.0102
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0051 0.0375
Entamoeba histolytica hypothetical protein 0.011 0.0113 0.1025
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0016 0.0044
Loa Loa (eye worm) hypothetical protein 0.0071 0.0063 0.0401
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0019 0.0168
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0042 0.0072
Mycobacterium ulcerans carboxylesterase, LipT 0.0071 0.0063 0.0172
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0127 0.0349
Echinococcus granulosus survival motor neuron protein 1 0.1221 0.1562 0.1562
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0108 0.0111 0.0817
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0241 0.0284 0.142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0009 0.0099
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Onchocerca volvulus 0.0249 0.0294 0.3192
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0035 0.0317
Echinococcus granulosus intermediate filament protein 0.0079 0.0072 0.0072
Plasmodium vivax glutathione reductase, putative 0.0047 0.0032 0.0162
Trypanosoma brucei DNA topoisomerase ii 0.1064 0.1357 1
Schistosoma mansoni nAChR subunit 0.005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Brugia malayi Carboxylesterase family protein 0.0422 0.052 0.3328
Brugia malayi Carboxylesterase family protein 0.0422 0.052 0.3328
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.0041 0.0265
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0127 0.0813
Loa Loa (eye worm) heat shock protein 75 0.0124 0.0131 0.0841
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.0164 0.045
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0108 0.0111 0.1003
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0149 0.0164 0.1047
Plasmodium vivax endoplasmin, putative 0.0349 0.0425 0.2416
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.018 0.0982
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0013 0.0121
Trichomonas vaginalis heat shock protein, putative 0.0241 0.0284 0.2568
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0121 0.0127 0.035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0111
Loa Loa (eye worm) hypothetical protein 0.0056 0.0043 0.0273
Echinococcus multilocularis transcription factor btf3 0.0034 0.0014 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Echinococcus granulosus casein kinase I delta 0.0039 0.0021 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0219 0.1612
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0009 0.0009
Trypanosoma cruzi casein kinase, putative 0.0039 0.0021 0.0152
Leishmania major casein kinase, putative 0.0039 0.0021 0.0152
Trypanosoma cruzi heat shock protein 85, putative 0.0241 0.0284 0.2091
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0043 0.0043
Onchocerca volvulus 0.0039 0.0021 0.0224
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0067 0.0067
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0495
Leishmania major hypothetical protein, conserved 0.0056 0.0043 0.0314
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0019 0.0019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0272 0.0325 0.0325
Loa Loa (eye worm) carboxylesterase 0.0422 0.052 0.3328
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0032 0.0032
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.0164 0.045
Brugia malayi hypothetical protein 0.0071 0.0063 0.0401
Trypanosoma cruzi casein kinase, putative 0.0039 0.0021 0.0152
Brugia malayi TAR-binding protein 0.0062 0.005 0.0322
Plasmodium vivax DNA topoisomerase 3, putative 0.0089 0.0085 0.047
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0102 0.065
Trypanosoma brucei DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Brugia malayi beta-NAC-like protein 0.0034 0.0014 0.0091
Mycobacterium ulcerans TetR family transcriptional regulator 0.2807 0.363 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0108 0.0111 0.0305
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0127 0.0349
Loa Loa (eye worm) endoplasmin 0.0349 0.0425 0.272
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Brugia malayi jmjC domain containing protein 0.0056 0.0043 0.0273
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0003 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.005 0.0035 0.0035
Leishmania major DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.0041 0.0304
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0051 0.0375
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0016 0.0044
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0019 0.0137
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0019 0.0137
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0021 0.0021
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0081 0.0081
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0108 0.0111 0.0305
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0088 0.0088
Echinococcus granulosus histone acetyltransferase KAT2B 0.0279 0.0334 0.0334
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0056 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0127 0.035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0087 0.0087
Echinococcus granulosus GPCR family 2 0.0047 0.0031 0.0031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0195
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0016 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Plasmodium falciparum casein kinase 1 0.0039 0.0021 0.0099
Brugia malayi Bromodomain containing protein 0.0044 0.0027 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0009 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0009 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0009 0.0058
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Plasmodium falciparum heat shock protein 90, putative 0.0124 0.0131 0.0733
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0071 0.0733
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0041 0.0218
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0108 0.0111 0.0407
Echinococcus multilocularis neuroligin 0.0071 0.0063 0.0063
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0108 0.0111 0.1003
Loa Loa (eye worm) LGC-31 protein 0.005 0.0035 0.0226
Trypanosoma cruzi heat shock protein 90, putative 0.0349 0.0425 0.3131
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0108 0.0111 0.0305
Chlamydia trachomatis DNA gyrase subunit A 0.0262 0.0311 0.1357
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1064 0.1357 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0087 0.0087
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0127 0.115
Schistosoma mansoni lipoxygenase 0.0118 0.0124 0.0124
Onchocerca volvulus 0.0038 0.0019 0.0204
Trichomonas vaginalis esterase, putative 0.0149 0.0164 0.148
Mycobacterium ulcerans hypothetical protein 0.0149 0.0164 0.045
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0016 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0009 0.0058
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0009 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0038 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Schistosoma mansoni hypothetical protein 0.0082 0.0077 0.0077
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0067 0.049
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0019 0.0193
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.005 0.0035 0.0226
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0 0.0001
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0089 0.0085 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0088 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0087 0.0087
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.005 0.0322
Brugia malayi PHD-finger family protein 0.0031 0.001 0.0067
Brugia malayi jmjC domain containing protein 0.0056 0.0043 0.0273
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.0035 0.0182
Loa Loa (eye worm) hypothetical protein 0.009 0.0087 0.0559
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0067 0.0602
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.0347 0.2224
Brugia malayi Carboxylesterase family protein 0.0071 0.0063 0.0401
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0089 0.0085 0.0258
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0009 0.0009
Brugia malayi beta-lactamase family protein 0.0149 0.0164 0.1047
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0063 0.0172
Toxoplasma gondii ABC1 family protein 0.0149 0.0164 0.0889
Toxoplasma gondii exonuclease III APE 0.0055 0.0041 0.0186
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0005 0.004
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0016 0.0102
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0111 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.005 0.005
Plasmodium vivax DNA gyrase subunit B, putative 0.0988 0.1259 0.7195
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.018 0.0567
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0019 0.0019
Onchocerca volvulus 0.0121 0.0127 0.1377
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0043 0.0273
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.0041 0.0428
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0009 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0109 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0009 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0001 0.0008
Echinococcus multilocularis lysine specific demethylase 5A 0.021 0.0243 0.0243
Brugia malayi hypothetical protein 0.0119 0.0124 0.0796
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0016 0.0044
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0089 0.0571
Leishmania major heat shock protein, putative 0.0124 0.0131 0.0967
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0003 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0077 0.007 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.005 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.0121 0.0127 0.035
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0781 0.0989 0.7287
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0111 0.0586
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Leishmania major hypothetical protein, conserved 0.0149 0.0164 0.1205
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0127 0.0308
Schistosoma mansoni hypothetical protein 0.0249 0.0294 0.0294
Loa Loa (eye worm) beta-lactamase 0.0149 0.0164 0.1047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0053 0.0336
Mycobacterium leprae Probable two-component sensor kinase 0.0108 0.0111 0.0263
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0071 0.0063 0.0063
Onchocerca volvulus 0.0071 0.0063 0.0679
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Trichomonas vaginalis DNA topoisomerase II, putative 0.087 0.1104 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0043 0.0314
Plasmodium vivax DNA gyrase subunit A, putative 0.1364 0.1748 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0161 0.018 0.018
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Mycobacterium ulcerans DNA gyrase subunit A 0.1364 0.1748 0.4815
Brugia malayi cathepsin L-like precursor 0.0034 0.0013 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0127 0.035
Trichomonas vaginalis heat shock protein, putative 0.0124 0.0131 0.1188
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0016 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0164 0.148
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0003 0.003
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0083 0.0456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0102
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Trichomonas vaginalis endoplasmin, putative 0.0232 0.0272 0.2466
Brugia malayi intermediate filament protein 0.0079 0.0072 0.0463
Onchocerca volvulus 0.005 0.0035 0.0383
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0089 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0035 0.0317
Onchocerca volvulus 0.0071 0.0063 0.0679
Plasmodium falciparum DNA topoisomerase 3, putative 0.0089 0.0085 0.047
Loa Loa (eye worm) hypothetical protein 0.0061 0.0049 0.0315
Schistosoma mansoni transcription factor btf3 0.0034 0.0014 0.0014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.0164 0.1047
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0124 0.0131 0.1188
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0127 0.0308
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0016 0.0117
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0079 0.0503
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Onchocerca volvulus Huntingtin homolog 0.0119 0.0124 0.1348
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.005 0.0035 0.0226
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0132 0.0132
Echinococcus granulosus DNA topoisomerase 2 alpha 0.087 0.1104 0.1104
Chlamydia trachomatis DNA gyrase subunit B 0.0988 0.1259 0.7057
Echinococcus multilocularis dual specificity 0.0092 0.0089 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Plasmodium falciparum acyl-CoA synthetase 0.009 0.0087 0.0481
Trypanosoma brucei heat shock protein, putative 0.0349 0.0425 0.3131
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0019 0.012
Trypanosoma cruzi Heat shock protein 83, putative 0.0349 0.0425 0.3131
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0038 0.0164
Leishmania major DNA topoisomerase III, putative 0.0089 0.0085 0.0629
Brugia malayi Cation transporter family protein 0.005 0.0035 0.0226
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0226
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0035 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0009 0.0058
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0062 0.0051 0.0241
Brugia malayi PHD-finger family protein 0.003 0.0009 0.0058
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0127 0.0307
Trypanosoma brucei trypanothione reductase 0.0047 0.0032 0.0232
Schistosoma mansoni hypothetical protein 0.011 0.0113 0.0113
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.005 0.0035 0.0035
Loa Loa (eye worm) TOPoisomerase family member 0.087 0.1104 0.7071
Loa Loa (eye worm) hypothetical protein 0.005 0.0035 0.0225
Echinococcus granulosus nAChR subunit 0.0027 0.0005 0.0005
Onchocerca volvulus 0.0089 0.0085 0.0926
Brugia malayi CHE-14 protein 0.0085 0.0081 0.0519
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.0025 0.0158
Trypanosoma cruzi heat shock protein 90, putative 0.0241 0.0284 0.2091
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0422 0.052 0.052
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0027 0.0005 0.0033
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0119 0.0124 0.0796
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0043 0.0043
Onchocerca volvulus Huntingtin homolog 0.0119 0.0124 0.1348
Trypanosoma cruzi casein kinase, putative 0.0039 0.0021 0.0152
Loa Loa (eye worm) hypothetical protein 0.0302 0.0364 0.2328
Leishmania major cathepsin L-like protease 0.005 0.0035 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0013 0.0121
Brugia malayi beta-lactamase 0.0149 0.0164 0.1047
Brugia malayi excitatory GABA receptor EXP-1A 0.005 0.0035 0.0226
Toxoplasma gondii thioredoxin reductase 0.0047 0.0032 0.013
Onchocerca volvulus Alhambra homolog 0.003 0.0009 0.0098
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0161 0.018 0.0453
Leishmania major mitochondrial DNA topoisomerase II 0.1064 0.1357 1
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0035 0.0035
Onchocerca volvulus 0.003 0.0009 0.0099
Brugia malayi jmjC domain containing protein 0.0056 0.0043 0.0273
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0019 0.0137
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.005 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.005 0.0035 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.0229 0.0229
Onchocerca volvulus 0.0149 0.0164 0.1773
Echinococcus granulosus BC026374 protein S09 family 0.0071 0.0063 0.0063
Echinococcus multilocularis nAChR subunit 0.0027 0.0005 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0219 0.1612
Plasmodium vivax casein kinase 1, putative 0.0039 0.0021 0.0099
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.363 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0045 0.0045
Giardia lamblia PHD finger protein 15 0.003 0.0009 0.0093
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0249 0.0294 0.1885
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0089 0.0085 0.0629
Brugia malayi hypothetical protein 0.0034 0.0013 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0009 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0003 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.034 0.3074
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0109 0.0109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.0164 0.045
Loa Loa (eye worm) acetyltransferase 0.029 0.0347 0.2224
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0051 0.0375
Loa Loa (eye worm) glutathione reductase 0.0047 0.0032 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0009 0.0058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0013 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0035 0.0226
Schistosoma mansoni hypothetical protein 0.0082 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0035 0.0317
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0016 0.0044
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0108 0.0111 0.0305
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0016 0.0016
Echinococcus granulosus tumor protein p63 0.1717 0.2209 0.2209
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0019 0.0168
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0035 0.0035
Echinococcus multilocularis acetylcholinesterase 0.0422 0.052 0.052
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0009 0.0009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0124 0.0124
Leishmania major heat shock protein 83-1 0.0349 0.0425 0.3131
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.087 0.1104 0.7071
Leishmania major protein kinase, putative 0.0062 0.0051 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0081 0.0733
Schistosoma mansoni heat shock protein 0.0349 0.0425 0.0425
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0164 0.0164
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.0035 0.0182
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0016 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0164 0.148
Echinococcus multilocularis expressed conserved protein 0.0187 0.0213 0.0213

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.079457844 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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