Detailed information for compound 1345685

Basic information

Technical information
  • TDR Targets ID: 1345685
  • Name: 8-(1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazin -6-yl)quinoline
  • MW: 302.373 | Formula: C19H18N4
  • H donors: 0 H acceptors: 3 LogP: 3.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nnc(c2c1c(C)n(c2C)c1cccc2c1nccc2)C
  • InChi: 1S/C19H18N4/c1-11-17-13(3)23(14(4)18(17)12(2)22-21-11)16-9-5-7-15-8-6-10-20-19(15)16/h5-10H,1-4H3
  • InChiKey: WIGQBWDXTHLXBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(1,4,5,7-tetramethyl-6-pyrrolo[3,4-d]pyridazinyl)quinoline
  • A3913/0166438
  • ZINC00551158
  • 8-(1,4,5,7-Tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-quinoline
  • BAS 04358844
  • MLS000764639
  • SMR000290244
  • Oprea1_203739

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0007 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0072 0.007
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0314 0.0412
Echinococcus granulosus nmda type glutamate receptor 0.0142 0.0663 0.0872
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0289 0.0379
Loa Loa (eye worm) hypothetical protein 0.0105 0.047 0.0468
Brugia malayi Uncoordinated protein 44 0.0015 0.0002 0.0000000046362
Schistosoma mansoni amine GPCR 0.0075 0.0314 0.0412
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0062 0.2844
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni lipoxygenase 0.0126 0.0578 0.076
Loa Loa (eye worm) hypothetical protein 0.0311 0.1544 0.1543
Trichomonas vaginalis inositol monophosphatase, putative 0.0156 0.0733 0.4137
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0028 0.0069 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0107 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0107 0.01
Brugia malayi Cytochrome P450 family protein 0.0026 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Brugia malayi metabotropic glutamate receptor type 2 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Loa Loa (eye worm) LGC-31 protein 0.0052 0.0194 0.0192
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0139 0.0648 0.4702
Schistosoma mansoni rab6-interacting 0.0021 0.0032 0.0039
Echinococcus multilocularis glutamate receptor 2 0.0173 0.0825 0.1086
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Brugia malayi putative neuropeptide receptor 0.0075 0.0314 0.0312
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0578 0.076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0153 0.02
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus synaptic vesicular amine transporter 0.0198 0.0953 0.1255
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0128 0.6442
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0019
Schistosoma mansoni histamine h1 receptor 0.0075 0.0314 0.0412
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0289 0.0287
Brugia malayi Cation transporter family protein 0.0126 0.058 0.0578
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0024 0.0048 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0149 0.1039
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.2694
Onchocerca volvulus 0.0075 0.0314 0.0908
Onchocerca volvulus 0.0016 0.0007 0.0014
Schistosoma mansoni acetylcholine receptor-related 0.0024 0.0048 0.006
Echinococcus granulosus glutamate receptor NMDA 0.0084 0.0361 0.0473
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.0314 0.0412
Brugia malayi isocitrate dehydrogenase 0.0017 0.0008 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0156 0.0733 0.8921
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Brugia malayi jmjC domain containing protein 0.0071 0.0292 0.029
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0173 0.0825 0.1086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.0314 0.0412
Echinococcus multilocularis inositol monophosphatase 0.0016 0.0007 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.0733 0.0727
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0007 0.0005
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0021 0.0283
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.0314 0.0412
Echinococcus granulosus tar DNA binding protein 0.0065 0.0262 0.0343
Schistosoma mansoni lamin 0.0029 0.0072 0.0092
Schistosoma mansoni hypothetical protein 0.0075 0.0314 0.0412
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0021 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0095
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0058 0.0225 0.0294
Plasmodium vivax amine transporter, putative 0.0053 0.0197 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0039 0.0037
Schistosoma mansoni inositol monophosphatase 0.0156 0.0733 0.0964
Echinococcus granulosus neuropeptide s receptor 0.0075 0.0314 0.0412
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.0314 0.0412
Echinococcus multilocularis serotonin receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0014 0.0016
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0289 0.1609
Plasmodium falciparum amino acid transporter, putative 0.0053 0.0197 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0026 0.0058 0.0628
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.074 0.0974
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0128 0.0121
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0526 0.0525
Schistosoma mansoni adenoreceptor 0.0075 0.0314 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0026 0.0058 0.0628
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0008 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0314 0.0412
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0026 0.0058 0.0375
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.0195
Schistosoma mansoni vesicular acetylcholine transporter 0.0675 0.3443 0.4538
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.0314 0.0312
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0085 0.4068
Echinococcus granulosus tyrosine kinase 0.0016 0.0007 0.0006
Loa Loa (eye worm) RNA binding protein 0.0065 0.0262 0.026
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0821 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0053 0.0197 0.0195
Schistosoma mansoni hypothetical protein 0.0698 0.3563 0.4697
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0053 0.0197 0.0258
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0058 0.0225 0.0294
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0032 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0128 0.1481
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0016 0.0007 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0116 0.015
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0007 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0314 0.0412
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0149 0.1741
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Brugia malayi glutathione reductase 0.0037 0.0113 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0455 0.0453
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0002 0.0000000061141
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0053 0.0197 0.0258
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0085 0.4068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0007 0.0005
Brugia malayi 6-phosphofructokinase 0.0116 0.0526 0.0525
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0058 0.0225 0.0294
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0052 0.0194 0.0192
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0032 0.003
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0314 0.0412
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0069 0.0067
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Echinococcus granulosus GPCR family 2 0.0033 0.0096 0.0123
Brugia malayi TAR-binding protein 0.0065 0.0262 0.026
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0058 0.0051
Brugia malayi Thioredoxin reductase 0.0037 0.0113 0.0111
Echinococcus multilocularis inositol monophosphatase 1 0.0156 0.0733 0.0964
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.0314 0.0412
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0008 0.0009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0096 0.0123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0292 0.0383
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0526 0.052
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0124 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0314 0.0412
Schistosoma mansoni hypothetical protein 0.0021 0.0032 0.0039
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0024 0.0048 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Echinococcus granulosus phd:f box containing protein 0.0019 0.0021 0.0025
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0289 0.0283
Brugia malayi Inositol-1 0.0156 0.0733 0.0731
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0024 0.0048 0.0046
Onchocerca volvulus 0.0075 0.0314 0.0908
Loa Loa (eye worm) cytochrome P450 0.0026 0.0058 0.0056
Loa Loa (eye worm) RecQ helicase 0.0022 0.0039 0.0037
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0058 0.0225 0.0294
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Leishmania major hypothetical protein, conserved 0.0043 0.0149 0.0142
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0007 0.0005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0021 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0358 0.2578
Leishmania major protein kinase, putative 0.0018 0.0018 0.0011
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus granulosus glutamate receptor 2 0.0173 0.0825 0.1086
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.0314 0.0412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0149 0.7519
Brugia malayi hypothetical protein 0.0016 0.0007 0.0005
Schistosoma mansoni opsin-like receptor 0.0075 0.0314 0.0412
Schistosoma mansoni amine GPCR 0.0075 0.0314 0.0412
Schistosoma mansoni pap-inositol-14-phosphatase 0.0016 0.0007 0.0007
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0002 0.0000000061141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0048 0.006
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0007 0.0005
Brugia malayi Dopamine receptor 0.0075 0.0314 0.0312
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.0314 0.0412
Echinococcus granulosus neuropeptide receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.0825 0.1086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0128 0.0252
Echinococcus granulosus tm gpcr rhodopsin 0.113 0.5813 0.7665
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0062 0.0056
Echinococcus granulosus g protein coupled receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0053 0.0197 0.0258
Echinococcus granulosus microtubule associated protein 2 0.147 0.7583 1
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0058 0.0225 0.0294
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.0314 0.0412
Echinococcus multilocularis neuropeptide receptor A26 0.0075 0.0314 0.0412
Echinococcus granulosus fmrfamide receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Schistosoma mansoni inositol monophosphatase 0.0156 0.0733 0.0964
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0128 0.0687
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0289 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0153 0.02
Echinococcus multilocularis vesicular acetylcholine transporter 0.0675 0.3443 0.4538
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.0314 0.0412
Echinococcus granulosus bloom syndrome protein 0.0022 0.0039 0.0048
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0118 0.0117
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0048 0.0046
Echinococcus multilocularis serotonin receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0314 0.0312
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0292 0.0383
Echinococcus granulosus lamin dm0 0.0029 0.0072 0.0092
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0008 0.0002
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0128 0.0884
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.0314 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0526 0.296
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0821 0.597
Leishmania major hypothetical protein, conserved 0.0027 0.0062 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0262 0.0343
Schistosoma mansoni protein kinase 0.0016 0.0007 0.0006
Schistosoma mansoni ap endonuclease 0.0039 0.0128 0.0166
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi PAS domain containing protein 0.0051 0.0187 0.0185
Schistosoma mansoni hypothetical protein 0.0033 0.0096 0.0123
Brugia malayi hypothetical protein 0.0171 0.0812 0.0811
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0052 0.0194 0.0192
Trypanosoma brucei C-8 sterol isomerase, putative 0.1933 1 1
Schistosoma mansoni neuropeptide receptor 0.0075 0.0314 0.0412
Brugia malayi hypothetical protein 0.0024 0.0048 0.0046
Echinococcus granulosus sex peptide receptor 0.0075 0.0314 0.0412
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0289 0.0283
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.0314 0.0412
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.0016 0.0007 0.0002
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0085 0.1164
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.0314 0.0412
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0194 0.0192
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.0314 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0007 0.0005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0026 0.0058 0.0628
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0062 0.0055
Onchocerca volvulus 0.0029 0.0072 0.0203
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0016 0.0007 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0062 0.0848
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0526 0.6383
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0008 0.0001
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0289 0.0379
Brugia malayi hypothetical protein 0.0024 0.0048 0.0046
Echinococcus multilocularis Ankyrin 0.0015 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0007 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0358 0.2578
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.0197 0.0258
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0007 0.0005
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0028 0.0069 0.0088
Schistosoma mansoni hypothetical protein 0.0033 0.0096 0.0123
Echinococcus granulosus vesicular acetylcholine transporter 0.0675 0.3443 0.4538
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0019
Brugia malayi Death domain containing protein 0.0015 0.0002 0.0000000046362
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0026 0.0058 0.0628
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0052 0.0194 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0026 0.0058 0.0375
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0149 0.0147
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0026 0.0058 0.0628
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Mycobacterium ulcerans hypothetical protein 0.0043 0.0149 0.1741
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0314 0.0412
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0026 0.0058 0.0628
Echinococcus multilocularis lamin dm0 0.0029 0.0072 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0032 0.0039
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1762 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0311 0.1544 0.2035
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Brugia malayi neuropeptide F receptor 0.0075 0.0314 0.0312
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0016 0.0007 0.0006
Brugia malayi beta-lactamase 0.0043 0.0149 0.0147
Brugia malayi hypothetical protein 0.0024 0.0048 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Brugia malayi Glutamate receptor 1 precursor 0.0157 0.074 0.0739
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.047 0.0468
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.2694
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.0314 0.0312
Schistosoma mansoni biogenic amine receptor 0.0075 0.0314 0.0412
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.0314 0.0312
Brugia malayi RNA binding protein 0.0065 0.0262 0.026
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0262 0.0343
Brugia malayi Metabotropic glutamate receptor precursor. 0.0016 0.0007 0.0005
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0194 0.0253
Echinococcus granulosus orexin receptor type 2 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0075 0.0314 0.0908
Plasmodium falciparum transporter, putative 0.0053 0.0197 1
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0526 0.0692
Onchocerca volvulus 0.0075 0.0314 0.0908
Brugia malayi Dopamine receptor protein 2 0.0075 0.0314 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0526 0.052
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.0314 0.0312
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0032 0.1229
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0149 0.0142
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0024 0.0048 0.006
Brugia malayi hypothetical protein 0.0024 0.0048 0.0046
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0026 0.0058 0.0375
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0002 0.0000000061141
Schistosoma mansoni sodium/chloride dependent transporter 0.0311 0.1544 0.2035
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0311 0.1544 0.1543
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0008 0.0115
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0314 0.0412
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.011 0.059
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0026 0.0058 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Schistosoma mansoni amine GPCR 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0149 0.1039
Schistosoma mansoni tyrosine kinase 0.0016 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Schistosoma mansoni neurotransmitter gated ion channel 0.0024 0.0048 0.006
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0149 0.1741
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0024 0.0048 0.006
Echinococcus multilocularis geminin 0.0698 0.3563 0.4697
Schistosoma mansoni amine GPCR 0.0075 0.0314 0.0412
Brugia malayi sulfakinin receptor protein 0.0075 0.0314 0.0312
Brugia malayi AKH receptor 0.0075 0.0314 0.0312
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1762 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0262 0.026
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.0197 0.0258
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0358 0.2578
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.0314 0.0412
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0021 0.0025
Echinococcus granulosus glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0008 0.0006
Schistosoma mansoni sodium/chloride dependent transporter 0.0053 0.0197 0.0258
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.0825 0.1086
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0334 0.1661 0.2189
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0126 0.058 0.0763
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0142 0.0185
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Onchocerca volvulus 0.0075 0.0314 0.0908
Loa Loa (eye worm) glutamate receptor 1 0.0157 0.074 0.0739
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Loa Loa (eye worm) beta-lactamase 0.0043 0.0149 0.0147
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0116 0.015
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.047 0.0468
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0096 0.0123
Echinococcus multilocularis serotonin transporter 0.0311 0.1544 0.2035
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0026 0.0058 0.0375
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.0194 0.0192
Brugia malayi GnHR receptor homolog 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0021 0.0025
Brugia malayi hypothetical protein 0.0027 0.0062 0.006
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0026 0.0058 0.0375
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0016 0.0007 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0107 0.0105
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0052 0.0194 0.0192
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0134 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0026 0.0058 0.0375
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.0314 0.0412
Brugia malayi intermediate filament protein 0.0029 0.0072 0.007
Toxoplasma gondii hypothetical protein 0.0053 0.0197 0.2694
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0149 0.0147
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0262 0.0343
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0008 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.0825 0.1086
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.0195
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0026 0.0058 0.0375
Schistosoma mansoni amine GPCR 0.0075 0.0314 0.0412
Echinococcus multilocularis orexin receptor type 2 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0075 0.0314 0.0908
Onchocerca volvulus 0.0024 0.0048 0.0132
Onchocerca volvulus 0.0024 0.0048 0.0132
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.0195
Brugia malayi ORL1-like opioid receptor 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0139 0.0648 0.7876
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0085 0.4112
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0058 0.0051
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0578 0.076
Schistosoma mansoni acetylcholine receptor subunit beta 0.0024 0.0048 0.006
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.0314 0.0412
Leishmania major C-8 sterol isomerase-like protein 0.1933 1 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.0197 0.0258
Echinococcus granulosus serotonin transporter 0.0311 0.1544 0.2035
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0262 0.0343
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Trypanosoma brucei trypanothione reductase 0.0037 0.0113 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0128 0.0126
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0526 0.3811
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0194 0.0192
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) norepinephrine transporter 0.0311 0.1544 0.1543
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0149 0.0194
Brugia malayi beta-lactamase family protein 0.0043 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0314 0.0412
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0016 0.0007 0.0014
Echinococcus multilocularis NMDA receptor 0.0058 0.0225 0.0294
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0021 0.0025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0156 0.0733 1
Brugia malayi Cation transporter family protein 0.0052 0.0194 0.0192
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.0314 0.0312
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0026 0.0058 0.0375
Echinococcus granulosus glutamate receptor 2 0.0115 0.0522 0.0686
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0007 0.0006
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0194 0.0253
Onchocerca volvulus 0.0028 0.0069 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0113 0.0111
Schistosoma mansoni hypothetical protein 0.0698 0.3563 0.4697
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0149 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Echinococcus multilocularis receptor type guanylyl cyclase 0.0016 0.0007 0.0006
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0016 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni ap endonuclease 0.0039 0.0128 0.0166
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0024 0.0048 0.0046
Echinococcus multilocularis 0.0026 0.0058 0.0074
Brugia malayi hypothetical protein 0.0251 0.1231 0.1229
Echinococcus granulosus allatostatin A receptor 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0149 0.1039
Loa Loa (eye worm) hypothetical protein 0.0251 0.1231 0.1229
Mycobacterium ulcerans beta-lactamase 0.0043 0.0149 0.1741
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0058 0.0225 0.0294
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0026 0.0058 0.0375
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0039 0.0181
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0052 0.0194 0.0192
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus hypothetical protein 0.0075 0.0314 0.0412
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0026 0.0058 0.0375
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0052 0.0194 0.0253
Brugia malayi follicle stimulating hormone receptor 0.0321 0.1593 0.1592
Echinococcus granulosus g protein coupled receptor 0.0075 0.0314 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0052 0.0194 0.0253
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0021 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0048 0.0046
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1762 1
Schistosoma mansoni biogenic amine receptor 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0053 0.0197 0.0568
Loa Loa (eye worm) GABA receptor subunit 0.0028 0.0069 0.0067
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0085 0.1164
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0016 0.0007 0.0006
Echinococcus multilocularis nAChR subunit 0.0028 0.0069 0.0088
Echinococcus granulosus glutamate receptor subunit protein glur 0.0058 0.0225 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0314 0.0412
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0026 0.0058 0.0628
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0149 0.0807
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0194 0.0253
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Onchocerca volvulus Putative nachr subunit 0.0052 0.0194 0.0558
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0021 0.0025
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0058 0.0051
Loa Loa (eye worm) hypothetical protein 0.0126 0.058 0.0578
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.0314 0.0312
Toxoplasma gondii cytochrome p450 superfamily protein 0.0026 0.0058 0.0793
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0128 0.0687
Mycobacterium tuberculosis Conserved protein 0.0043 0.0149 0.1039
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Brugia malayi G-protein coupled receptor 0.0075 0.0314 0.0312
Schistosoma mansoni glutamate receptor kainate 0.0157 0.074 0.0974
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0314 0.0412
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Echinococcus multilocularis nAChR subunit 0.0052 0.0194 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0149 0.0807
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0149 0.1039
Echinococcus multilocularis somatostatin receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0096 0.0094
Echinococcus multilocularis RUN 0.0021 0.0032 0.0039
Echinococcus multilocularis GPCR, family 2 0.0033 0.0096 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0153 0.02
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0128 0.0166
Echinococcus multilocularis synaptic vesicular amine transporter 0.0198 0.0953 0.1255
Schistosoma mansoni myo inositol monophosphatase 0.0016 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.0733 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0053 0.0197 0.0258
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0008 0.0009
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0069 0.0088
Brugia malayi Glutamate receptor 2 precursor 0.0157 0.074 0.0739
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0149 0.0194
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0052 0.0194 0.0253
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0053 0.0197 0.0568
Brugia malayi jmjC domain containing protein 0.0071 0.0292 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0173 0.0825 0.1086
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0008 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0113 0.5719
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis glutamate receptor NMDA 0.0084 0.0361 0.0473
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0024 0.0048 0.006
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0526 0.2961
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.0314 0.0412
Loa Loa (eye worm) glutamate receptor 2 0.0157 0.074 0.0739
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0008 0.0115
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0314 0.0412
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0149 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0062 0.0056
Echinococcus multilocularis musashi 0.0029 0.0072 0.0092
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0128 0.0166
Trichomonas vaginalis esterase, putative 0.0043 0.0149 0.0807
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0292 0.0383
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0021 0.0025
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0314 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0052 0.0194 0.0253
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0062 0.3117
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0072 0.0297 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0149 0.0142
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0332 0.0435
Loa Loa (eye worm) hypothetical protein 0.1933 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0262 0.026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0149 0.1741
Brugia malayi hypothetical protein 0.0021 0.0032 0.003
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0526 0.0692
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0052 0.0194 0.0253
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Onchocerca volvulus 0.0126 0.058 0.1681
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0026 0.0058 0.0628
Loa Loa (eye worm) solute carrier family 6 member 4 0.0311 0.1544 0.1543
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0039 0.0181
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0314 0.0412
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0052 0.0194 0.0192
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.0314 0.0312
Brugia malayi Abnormal catecholamine distribution protein 1 0.0198 0.0953 0.0951
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0008 0.0009
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0052 0.0194 0.0253
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi hypothetical protein 0.0053 0.0197 0.0195
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.1231 0.1621
Mycobacterium tuberculosis Conserved protein 0.0043 0.0149 0.1039
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0358 0.2578
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0134 0.0175
Echinococcus granulosus RUN 0.0021 0.0032 0.0039
Loa Loa (eye worm) glutamate receptor 0.0016 0.0007 0.0005
Plasmodium vivax glutathione reductase, putative 0.0037 0.0113 0.5719
Brugia malayi neuropeptide F receptor 0.0075 0.0314 0.0312
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.0733 0.0726
Onchocerca volvulus 0.0038 0.0118 0.0339
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0526 0.2961
Brugia malayi vesicular acetylcholine transporter unc-17 0.0675 0.3443 0.3441
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0052 0.0194 0.0192
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0072 0.007
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0332 0.0435
Brugia malayi Protein kinase domain containing protein 0.0015 0.0002 0.0000000046362
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0019
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.0314 0.0412
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0526 0.052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Leishmania major cytochrome p450-like protein 0.0035 0.0107 0.01
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0321 0.1593 0.1592
Mycobacterium tuberculosis Probable reductase 0.0084 0.0358 0.2578
Onchocerca volvulus 0.0029 0.0072 0.0203
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0024 0.0048 0.006
Schistosoma mansoni glutamate receptor AMPA 0.0157 0.074 0.0974
Mycobacterium leprae Probable lipase LipE 0.0043 0.0149 0.1741
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Echinococcus granulosus metabotropic glutamate receptor 2 0.0016 0.0007 0.0006
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0021 0.0652
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.0194 0.0253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0008 0.0009
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0058 0.0225 0.0294
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0021 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Plasmodium falciparum thioredoxin reductase 0.0037 0.0113 0.5549
Schistosoma mansoni intermediate filament proteins 0.0029 0.0072 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Echinococcus granulosus somatostatin receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0008 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0062 0.2844
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0021 0.0283
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0311 0.1544 0.1543
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0026 0.0058 0.0628
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0292 0.0383
Schistosoma mansoni glutamate receptor NMDA 0.0257 0.1264 0.1664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Echinococcus multilocularis nmda type glutamate receptor 0.01 0.0445 0.0585
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0128 0.0688
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0053 0.0197 0.0258
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Onchocerca volvulus 0.0126 0.058 0.1681
Loa Loa (eye worm) hypothetical protein 0.0988 0.5073 0.5072
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0058 0.0051
Schistosoma mansoni glutamate receptor NMDA 0.0334 0.1661 0.2189
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Plasmodium vivax JmjC domain containing protein 0.0019 0.0021 0.1008
Brugia malayi Doublecortin family protein 0.0021 0.0032 0.003
Schistosoma mansoni ATP-binding cassette transporter 0.0157 0.074 0.0974
Schistosoma mansoni hypothetical protein 0.0026 0.0058 0.0074
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0026 0.0058 0.0628
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0052 0.0194 0.0253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0128 0.0121
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0153 0.0151
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0026 0.0058 0.0375
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0107 0.0105
Toxoplasma gondii hypothetical protein 0.0053 0.0197 0.2694
Echinococcus multilocularis glutamate receptor 2 0.0157 0.074 0.0974
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0058 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0526 0.296
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0128 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0021 0.0019
Brugia malayi hypothetical protein 0.0021 0.0032 0.003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0069 0.0067
Schistosoma mansoni rab6-interacting 0.0021 0.0032 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0149 0.0807
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0149 0.1039
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0292 0.0383
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0107 0.01
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0021 0.0025
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Loa Loa (eye worm) inositol-1 0.0156 0.0733 0.0731
Schistosoma mansoni opsin-like receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0951 0.4881 0.488
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0026 0.0058 0.0375
Onchocerca volvulus 0.0043 0.0149 0.0426
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0124 0.0122
Brugia malayi hypothetical protein 0.0017 0.0013 0.0011
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0021 0.0025
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.1231 0.1621
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0526 0.2631
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0153 0.02
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0187 0.0245
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0358 0.4317
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0194 0.0192
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0118 0.0154
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0526 0.0525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0096 0.0094
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.0314 0.0908
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0189 0.0187
Onchocerca volvulus 0.0043 0.0149 0.0426
Onchocerca volvulus 0.0051 0.0189 0.0544
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0526 0.296
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0053 0.0197 0.0258
Schistosoma mansoni tyrosine kinase 0.0016 0.0007 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.113 0.5813 0.7665
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0026 0.0058 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0124 0.0161
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0407 0.2935
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0951 0.4881 0.488
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0053 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Onchocerca volvulus 0.0311 0.1544 0.4483
Echinococcus granulosus glutamate NMDA receptor subunit 0.0334 0.1661 0.2189
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0262 0.026
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0052 0.0194 0.0253
Brugia malayi Guanylyl cyclase protein 23 0.0016 0.0007 0.0005
Schistosoma mansoni sodium-dependent amino acid transporter 0.0053 0.0197 0.0258
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0314 0.0412
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0028 0.0069 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0026 0.0058 0.0375
Echinococcus granulosus lamin 0.0029 0.0072 0.0092
Onchocerca volvulus 0.0024 0.0048 0.0132
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0026 0.0058 0.0628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0153 0.02
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0026 0.0058 0.0628
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Brugia malayi Melatonin receptor type 1A 0.0075 0.0314 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0096 0.0094
Echinococcus granulosus receptor type guanylyl cyclase 0.0016 0.0007 0.0006
Echinococcus granulosus intermediate filament protein 0.0029 0.0072 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0026 0.0058 0.0375
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.0314 0.0312
Brugia malayi Serotonin receptor 0.0075 0.0314 0.0312
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0314 0.0412
Brugia malayi RE15519p 0.0075 0.0314 0.0312
Echinococcus granulosus nAChR subunit 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0008 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0149 0.1039
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0149 0.0807
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0052 0.0194 0.0192
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0008 0.0009
Onchocerca volvulus 0.0075 0.0314 0.0908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0128 0.6301
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Mycobacterium ulcerans lipase LipD 0.0043 0.0149 0.1741
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0024 0.0048 0.0046
Schistosoma mansoni single-minded 0.0051 0.0187 0.0245
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0021 0.0014
Brugia malayi phosphofructokinase 0.0116 0.0526 0.0525
Schistosoma mansoni hypothetical protein 0.0075 0.0314 0.0412
Schistosoma mansoni nAChR subunit 0.0024 0.0048 0.006
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Onchocerca volvulus 0.0021 0.0032 0.0086
Onchocerca volvulus 0.0043 0.0149 0.0426
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0039 0.0048
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni lipoxygenase 0.0088 0.0381 0.0499
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.0314 0.0412
Brugia malayi Cytochrome P450 family protein 0.0035 0.0107 0.0105
Echinococcus granulosus neuropeptide receptor A26 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0052 0.0194 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0262 0.0343
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0156 0.0733 0.0727
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0173 0.0825 0.1086
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.0314 0.0312
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0021 0.0014
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0003 0.0001
Echinococcus multilocularis nmda type glutamate receptor 0.0142 0.0663 0.0872
Schistosoma mansoni hypothetical protein 0.0075 0.0314 0.0412
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0289 0.0379
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0821 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0526 0.6383
Brugia malayi larval opioid receptor 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0026 0.0058 0.0375
Loa Loa (eye worm) serotonin transporter b 0.0311 0.1544 0.1543
Onchocerca volvulus 0.0052 0.0194 0.0558
Loa Loa (eye worm) glutathione reductase 0.0037 0.0113 0.0111
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0053 0.0197 0.0568
Brugia malayi Cytochrome P450 family protein 0.0026 0.0058 0.0056
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0026 0.0058 0.0375
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1933 1 1
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.0825 0.1086
Loa Loa (eye worm) hypothetical protein 0.0311 0.1544 0.1543
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.0314 0.0312
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0085 0.0448
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0085 0.1164
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0153 0.02
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0007
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1762 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0292 0.0383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0314 0.0412
Echinococcus granulosus serotonin receptor 0.0075 0.0314 0.0412
Schistosoma mansoni biogenic amine receptor 0.0075 0.0314 0.0412
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0026 0.0058 0.0375
Echinococcus multilocularis sodium and chloride dependent glycine 0.0053 0.0197 0.0258
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi beta-lactamase family protein 0.0043 0.0149 0.0147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0026 0.0058 0.0375
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0314 0.0412
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0026 0.0058 0.0628
Schistosoma mansoni lamin 0.0029 0.0072 0.0092
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0118 0.1369
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.0314 0.0908
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Schistosoma mansoni glutamate receptor kainate 0.0157 0.074 0.0974
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0026 0.0058 0.0628
Onchocerca volvulus 0.0021 0.0032 0.0086
Schistosoma mansoni hypothetical protein 0.0033 0.0096 0.0123
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0032 0.1564
Brugia malayi Cytochrome P450 family protein 0.0035 0.0107 0.0105
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0407 0.2935
Loa Loa (eye worm) hypothetical protein 0.0171 0.0812 0.0811
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.011 0.059
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0052 0.0194 0.0253
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0026 0.0058 0.0628
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0407 0.4916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Brugia malayi 6-phosphofructokinase 0.0116 0.0526 0.0525
Echinococcus granulosus nmda type glutamate receptor 0.01 0.0445 0.0585
Echinococcus granulosus Ankyrin 0.0015 0.0003 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.137 1
Schistosoma mansoni metabotropic glutamate receptor 0.0016 0.0007 0.0006
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0026 0.0058 0.0628
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0021 0.0014
Leishmania major cytochrome p450-like protein 0.0026 0.0058 0.0051
Schistosoma mansoni survival motor neuron protein 0.0051 0.0189 0.0247
Leishmania major cytochrome p450-like protein 0.0026 0.0058 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0526 0.296
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0292 0.0383
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0026 0.0058 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0096 0.0123
Onchocerca volvulus 0.0075 0.0314 0.0908
Schistosoma mansoni polycystin 1-related 0.0021 0.0032 0.0039
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0024 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0526 0.0692
Brugia malayi Dopamine receptor protein 1 0.0075 0.0314 0.0312
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0021 0.0025
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0019
Entamoeba histolytica hypothetical protein 0.0028 0.0069 0.0353
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Echinococcus granulosus inositol monophosphatase 1 0.0156 0.0733 0.0964
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0026 0.0058 0.0375
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0153 0.0151
Toxoplasma gondii exonuclease III APE 0.0039 0.0128 0.174
Brugia malayi G protein-coupled receptor 0.0075 0.0314 0.0312
Mycobacterium leprae Conserved hypothetical protein 0.0026 0.0058 0.0628
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0142 0.0185
Schistosoma mansoni vesicular amine transporter 0.0198 0.0953 0.1255
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0314 0.0312
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0096 0.0123
Brugia malayi hypothetical protein 0.0075 0.0314 0.0312
Toxoplasma gondii hypothetical protein 0.0016 0.0007 0.0096
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Schistosoma mansoni cytochrome P450 0.0026 0.0058 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0153 0.02
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0149 0.1039
Schistosoma mansoni microtubule-associated protein tau 0.147 0.7583 1
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.0314 0.0312
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0314 0.0312
Loa Loa (eye worm) RGC/RGC protein kinase 0.0016 0.0007 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0052 0.0194 0.0253
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0197 0.0195
Schistosoma mansoni myosin xvIII 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0314 0.0412
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0113 0.0107
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Echinococcus multilocularis allatostatin A receptor 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Loa Loa (eye worm) acetylcholine receptor protein 0.0024 0.0048 0.0046
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus multilocularis glutamate receptor 2 0.0115 0.0522 0.0686
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Brugia malayi G-protein coupled receptor 0.0075 0.0314 0.0312
Echinococcus multilocularis sex peptide receptor 0.0075 0.0314 0.0412
Schistosoma mansoni neuropeptide receptor 0.0075 0.0314 0.0412
Schistosoma mansoni opsin-like receptor 0.0075 0.0314 0.0412
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0026 0.0058 0.0628
Schistosoma mansoni hypothetical protein 0.0058 0.0225 0.0294
Echinococcus granulosus nAChR subunit 0.0028 0.0069 0.0088
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0358 0.2578
Brugia malayi excitatory GABA receptor EXP-1A 0.0052 0.0194 0.0192
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0526 0.2961
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.0195
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0052 0.0194 0.0192
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0126 0.058 0.0763
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0027 0.0062 0.006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0314 0.0412
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0025 0.0853
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis neuropeptide s receptor 0.0075 0.0314 0.0412
Echinococcus multilocularis tyrosine kinase 0.0016 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Onchocerca volvulus 0.0052 0.0194 0.0558
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0292 0.029
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0085 0.0446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0128 0.0121
Schistosoma mansoni glutamate receptor kainate 0.0157 0.074 0.0974
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0026 0.0058 0.0628
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0072 0.007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0124 0.0161
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.0314 0.0412
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.0314 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0194 0.0253
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0289 0.0287
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0128 0.0687
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0075 0.0314 0.0908
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0107 0.1227
Onchocerca volvulus 0.0126 0.058 0.1681
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.0733 0.4137
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0024 0.0048 0.0046
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0052 0.0194 0.0253
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0053 0.0197 0.0258
Schistosoma mansoni hypothetical protein 0.0051 0.0189 0.0247
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0314 0.0412
Leishmania major trypanothione reductase 0.0037 0.0113 0.0107
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0052 0.0194 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0085 0.0446
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0407 0.2935
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.0743 0.0742
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0085 0.4294
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0675 0.3443 0.3441
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0173 0.0825 0.1086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0156 0.0733 0.4138
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.047 0.0468
Loa Loa (eye worm) hypothetical protein 0.0043 0.0149 0.0147
Echinococcus granulosus metabotropic glutamate receptor 5 0.0016 0.0007 0.0006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0008 0.0002
Toxoplasma gondii ABC1 family protein 0.0043 0.0149 0.2028
Brugia malayi Serotonin receptor 0.0075 0.0314 0.0312
Schistosoma mansoni loxhd1 0.0021 0.0032 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0107 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Echinococcus granulosus glycine receptor subunit beta 0.0052 0.0194 0.0253
Mycobacterium tuberculosis Conserved protein 0.0043 0.0149 0.1039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Schistosoma mansoni nAChR subunit 0.0052 0.0194 0.0253
Schistosoma mansoni hypothetical protein 0.0075 0.0314 0.0412
Loa Loa (eye worm) hypothetical protein 0.0052 0.0194 0.0192
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0149 0.0194
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0314 0.0412
Echinococcus granulosus neuropeptide receptor 0.0075 0.0314 0.0412
Schistosoma mansoni neuropeptide receptor 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0028 0.0069 0.0194
Echinococcus multilocularis lamin 0.0029 0.0072 0.0092
Echinococcus multilocularis microtubule associated protein 2 0.147 0.7583 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0156 0.0733 0.4137
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0113 0.078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0053 0.0197 0.0258
Treponema pallidum sodium- and chloride- dependent transporter 0.0311 0.1544 0.8703
Onchocerca volvulus 0.0075 0.0314 0.0908
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0058 0.0074
Echinococcus granulosus g protein coupled receptor 0.0075 0.0314 0.0412
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0156 0.0733 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.2694
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0067
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0314 0.0412
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.0314 0.0412
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0016 0.0007 0.0005
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0053 0.0197 0.0195
Echinococcus multilocularis glycine receptor subunit beta 0.0052 0.0194 0.0253
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0314 0.0412
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0675 0.3443 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0526 0.0525
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.0314 0.0412
Schistosoma mansoni nAChR subunit 0.0024 0.0048 0.006
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0085 0.0446
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0198 0.0953 0.0951
Loa Loa (eye worm) ACC-1 protein 0.0052 0.0194 0.0192
Echinococcus granulosus atrial natriuretic peptide receptor 0.0016 0.0007 0.0006
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0052 0.0194 0.0253
Schistosoma mansoni hypothetical protein 0.0033 0.0096 0.0123
Brugia malayi jmjC domain containing protein 0.0019 0.0021 0.0019
Plasmodium falciparum glutathione reductase 0.0037 0.0113 0.5549
Schistosoma mansoni neuropeptide receptor 0.0075 0.0314 0.0412
Echinococcus granulosus inositol monophosphatase 0.0016 0.0007 0.0007
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0058 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1762 1
Brugia malayi Inositol monophosphatase family protein 0.0016 0.0007 0.0005
Echinococcus granulosus geminin 0.0698 0.3563 0.4697
Schistosoma mansoni hypothetical protein 0.0072 0.0297 0.0389
Brugia malayi Cation transporter family protein 0.0052 0.0194 0.0192
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0526 0.0692
Onchocerca volvulus 0.0016 0.0007 0.0014
Brugia malayi hypothetical protein 0.0024 0.0048 0.0046
Brugia malayi hypoxia-induced factor 1 0.0158 0.0743 0.0742
Echinococcus granulosus single minded 2 0.0041 0.0137 0.0178
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0075 0.0314 0.0312
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0085 0.4294
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0297 0.0295
Toxoplasma gondii thioredoxin reductase 0.0037 0.0113 0.1546
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0085 0.4112
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0052 0.0194 0.0192
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0126 0.058 0.0578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0019
Echinococcus granulosus g-protein coupled receptor 0.0075 0.0314 0.0412
Onchocerca volvulus 0.0075 0.0314 0.0908
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.0314 0.0312
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0289 0.0283
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0262 0.0343
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0053 0.0197 0.0258
Brugia malayi cytochrome P450 0.0026 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0046
Mycobacterium leprae putative cytochrome p450 0.0026 0.0058 0.0628
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0028 0.0069 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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