Detailed information for compound 1389304

Basic information

Technical information
  • TDR Targets ID: 1389304
  • Name: N-(4-acetamidophenyl)-N-[2-(cyclohexylamino)- 1-(4-hydroxyphenyl)-2-oxoethyl]pyrazine-2-car boxamide
  • MW: 487.55 | Formula: C27H29N5O4
  • H donors: 3 H acceptors: 6 LogP: 2.81 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)N(C(=O)c1cnccn1)C(c1ccc(cc1)O)C(=O)NC1CCCCC1
  • InChi: 1S/C27H29N5O4/c1-18(33)30-21-9-11-22(12-10-21)32(27(36)24-17-28-15-16-29-24)25(19-7-13-23(34)14-8-19)26(35)31-20-5-3-2-4-6-20/h7-17,20,25,34H,2-6H2,1H3,(H,30,33)(H,31,35)
  • InChiKey: GIEPWPMJXAECHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-acetamidophenyl)-N-[2-(cyclohexylamino)-1-(4-hydroxyphenyl)-2-oxo-ethyl]pyrazine-2-carboxamide
  • N-(4-acetamidophenyl)-N-[2-(cyclohexylamino)-1-(4-hydroxyphenyl)-2-oxoethyl]-2-pyrazinecarboxamide
  • N-(4-acetamidophenyl)-N-[2-(cyclohexylamino)-1-(4-hydroxyphenyl)-2-keto-ethyl]pyrazinamide
  • MLS000070538
  • Oprea1_292612
  • ASN 04361594
  • Pyrazine-2-carboxylic acid (4-acetylamino-phenyl)-[cyclohexylcarbamoyl-(4-hydroxy-phenyl)-methyl]-amide
  • SMR000003092

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis protein tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.0083 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0128 0.0805
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0058 0.0083 0.0099
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Plasmodium falciparum serine/threonine protein kinase, putative 0.0079 0.0128 0.7122
Entamoeba histolytica tyrosin kinase, putative 0.0058 0.0083 0.0524
Echinococcus multilocularis Pleckstrin y 0.007 0.0109 0.013
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.007 0.0109 0.0687
Plasmodium vivax tyrosine kinase-like protein, putative 0.0058 0.0083 0.463
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3934 0.8372 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0058 0.0083 0.0099
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0058 0.0083 0.0099
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0076 0.0123 0.6869
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Echinococcus granulosus activated cdc42 kinase 1 0.0058 0.0083 0.0099
Onchocerca volvulus 0.0058 0.0083 0.0442
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Toxoplasma gondii hypothetical protein 0.007 0.0109 0.6078
Brugia malayi Egg laying defective protein 4 0.0024 0.0012 0.0012
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus multilocularis tyrosine kinase 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0012 0.0014
Loa Loa (eye worm) serine/threonine protein kinase 0.0058 0.0083 0.0083
Brugia malayi PXA domain containing protein 0.0761 0.1588 0.1588
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0036 0.2002
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis transfer RNA-Thr 0.0058 0.0083 0.0099
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0058 0.0083 0.463
Echinococcus granulosus regulator of G protein signaling 3 0.0761 0.1588 0.1896
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0167 0.0316 0.0316
Brugia malayi hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.007 0.0109 0.0687
Echinococcus granulosus Oxysterol binding protein 11 0.007 0.0109 0.013
Trichomonas vaginalis centaurin alpha, putative 0.007 0.0109 0.0687
Echinococcus granulosus Rho GTPase activating protein 24 0.007 0.0109 0.013
Echinococcus multilocularis oxysterol binding protein 1 0.007 0.0109 0.013
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0058 0.0083 0.0099
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0109 0.6078
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.0461 0.8918
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus granulosus titin 0.0024 0.0011 0.0013
Trypanosoma cruzi aurora B kinase, putative 0.0079 0.0128 0.7122
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.0083 0.0083
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0036 0.2002
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Echinococcus granulosus c src tyrosine kinase 0.0058 0.0083 0.0099
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.007 0.0109 0.0687
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.018 0.3473
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0058 0.0083 0.0524
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0058 0.0083 0.0083
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1016 0.1214
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica ankyrin repeat protein 0.0058 0.0083 0.0524
Brugia malayi hypothetical protein 0.0029 0.0022 0.0022
Echinococcus granulosus GRB2 associated binding protein 3 0.007 0.0109 0.013
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus multilocularis roundabout 2 0.0121 0.0218 0.026
Echinococcus multilocularis aurora kinase A 0.0079 0.0128 0.0153
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0116 0.0207 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1016 0.1214
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0076 0.0123 0.0123
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0083 0.0524
Trypanosoma brucei protein kinase, putative 0.0076 0.0123 0.6869
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0058 0.0083 0.463
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.007 0.0109 0.013
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus multilocularis expressed conserved protein 0.0024 0.0012 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.007 0.0109 0.013
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3934 0.8372 0.8372
Onchocerca volvulus 0.007 0.0109 0.0581
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni axis inhibition protein axin 0.0761 0.1588 0.1588
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Echinococcus multilocularis Immunoglobulin 0.0116 0.0207 0.0247
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.0461 0.8918
Brugia malayi Plexin repeat family protein 0.0898 0.1879 0.1879
Entamoeba histolytica hypothetical protein 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0036 0.2002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0022
Onchocerca volvulus 0.0024 0.0011 0.0058
Leishmania major protein kinase, putative 0.0089 0.0149 0.8317
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0058 0.0083 0.0083
Leishmania major protein kinase, putative 0.0024 0.0012 0.0644
Echinococcus granulosus pdz domain containing protein 0.007 0.0109 0.013
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0036 0.5
Entamoeba histolytica protein kinase, putative 0.0079 0.0128 0.0805
Trichomonas vaginalis TK family protein kinase 0.0058 0.0083 0.0524
Giardia lamblia Kinase 0.0058 0.0083 0.6501
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0036 0.2002
Trypanosoma cruzi NIMA-related kinase, putative 0.0089 0.0149 0.8317
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.0461 0.8918
Brugia malayi Thioredoxin reductase 0.0103 0.018 0.018
Brugia malayi Pleckstrin Homology Domain 0.007 0.0109 0.0109
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0058 0.0083 0.0099
Brugia malayi Cytohesin 3 0.007 0.0109 0.0109
Echinococcus multilocularis natriuretic peptide receptor 1 0.0058 0.0083 0.0099
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0089 0.0149 0.8317
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni fibrocystin l 0.0167 0.0316 0.0316
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0036 0.2002
Schistosoma mansoni hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni hypothetical protein 0.0058 0.0083 0.0083
Trypanosoma brucei rac serine-threonine kinase, putative 0.0089 0.0149 0.8317
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Brugia malayi Immunoglobulin I-set domain containing protein 0.0173 0.033 0.033
Brugia malayi regulator of G-protein signaling rgs-7 0.0761 0.1588 0.1588
Echinococcus multilocularis activated cdc42 kinase 1 0.0058 0.0083 0.0099
Schistosoma mansoni goodpasture antigen-binding protein 0.007 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni protein tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi Protein kinase B 0.0089 0.0149 0.8317
Echinococcus granulosus semaphorin 5B 0.0381 0.0774 0.0924
Loa Loa (eye worm) TK/DDR protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0076 0.0123 0.0777
Plasmodium falciparum tyrosine kinase-like protein 0.0058 0.0083 0.463
Entamoeba histolytica hypothetical protein 0.0761 0.1588 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0036 0.2811
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Plasmodium vivax conserved Plasmodium protein, unknown function 0.007 0.0109 0.6078
Echinococcus granulosus cGMP dependent protein kinase 0.0024 0.0012 0.0014
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0058 0.0083 0.0099
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0167 0.0316 0.1993
Loa Loa (eye worm) plexin A 0.1065 0.2236 0.2236
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma brucei protein kinase, putative 0.0089 0.0149 0.8317
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Echinococcus multilocularis axis inhibition protein axin 0.0761 0.1588 0.1896
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Echinococcus multilocularis GRB2 associated binding protein 3 0.007 0.0109 0.013
Loa Loa (eye worm) AUR protein kinase 0.0079 0.0128 0.0128
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0036 0.0695
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Giardia lamblia Protein 21.1 0.0058 0.0083 0.6501
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus granulosus beta-adrenergic receptor kinase 0.3599 0.7656 0.9144
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Echinococcus multilocularis myotubularin protein 13 0.007 0.0109 0.013
Entamoeba histolytica p21-activated kinase 0.0089 0.0149 0.0941
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Onchocerca volvulus 0.0058 0.0083 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) variant SH3 domain-containing protein 0.007 0.0109 0.0109
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0058 0.0083 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.007 0.0109 0.013
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Loa Loa (eye worm) sema domain-containing protein 0.0381 0.0774 0.0774
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0036 0.2002
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Echinococcus granulosus plexin a4 0.1065 0.2236 0.2671
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Brugia malayi DNA-binding protein LAG-1 0.0167 0.0316 0.0316
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0089 0.0149 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0036 1
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0109 0.0687
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis protein KINase family member (kin 25) 0.0058 0.0083 0.0099
Schistosoma mansoni rhogef and pleckstrin domain protein 0.007 0.0109 0.0109
Echinococcus granulosus tyrosine protein kinase Src42A 0.0058 0.0083 0.0099
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Echinococcus multilocularis regulator of G protein signaling 7 0.0761 0.1588 0.1896
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0761 0.1588 0.1896
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Echinococcus multilocularis beta adrenergic receptor kinase 0.3599 0.7656 0.9144
Brugia malayi hypothetical protein 0.0381 0.0774 0.0774
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0089 0.0149 0.8317
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0036 0.2002
Echinococcus granulosus DCC interacting protein 13 beta 0.007 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.007 0.0109 0.013
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.007 0.0109 0.6078
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Onchocerca volvulus Tyrosine kinase homolog 0.0058 0.0083 0.0442
Trichomonas vaginalis protein transport protein sec7, putative 0.007 0.0109 0.0687
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Toxoplasma gondii thioredoxin reductase 0.0103 0.018 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0036 0.2002
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0036 0.0036
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus granulosus receptor type guanylyl cyclase 0.0058 0.0083 0.0099
Schistosoma mansoni hypothetical protein 0.0167 0.0316 0.0316
Leishmania major protein kinase, putative 0.0079 0.0128 0.7122
Echinococcus multilocularis protein tyrosine kinase 0.0058 0.0083 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.01 0.5585
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0121 0.0218 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Schistosoma mansoni titin 0.0024 0.0011 0.0011
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0022
Brugia malayi bone morphogenetic protein type 1 receptor 0.0058 0.0083 0.0083
Brugia malayi SH2 domain containing protein 0.0058 0.0083 0.0083
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0024 0.0011 0.0011
Loa Loa (eye worm) oxysterol binding protein 0.007 0.0109 0.0109
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trypanosoma brucei Flagellum attachment zone protein 20 0.0058 0.0083 0.463
Entamoeba histolytica hypothetical protein 0.0761 0.1588 1
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0761 0.1588 0.1588
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0036 0.2002
Schistosoma mansoni z-protein (S1r protein) 0.0761 0.1588 0.1588
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.0517 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) cytohesin 3 0.007 0.0109 0.0109
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.007 0.0109 0.0109
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Brugia malayi Dynamin 0.007 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni vesicular amine transporter 0.0118 0.0213 0.0213
Echinococcus granulosus insulin receptor 0.0058 0.0083 0.0099
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0761 0.1588 0.1896
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) AGC/PKG protein kinase 0.0024 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK/RYK protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0761 0.1588 0.1588
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.007 0.0109 0.013
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Onchocerca volvulus 0.0058 0.0083 0.0442
Brugia malayi Uncoordinated protein 104 0.007 0.0109 0.0109
Entamoeba histolytica hypothetical protein 0.0089 0.0149 0.0941
Echinococcus multilocularis regulator of G protein signaling 0.0761 0.1588 0.1896
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.007 0.0109 0.013
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.0461 0.8918
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0128 0.0128
Schistosoma mansoni ephrin receptor 0.0063 0.0094 0.0094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Echinococcus granulosus tyrosine kinase 0.0058 0.0083 0.0099
Schistosoma mansoni zinc finger protein 0.007 0.0109 0.0109
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0089 0.0149 0.8317
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Echinococcus granulosus tyrosine protein kinase HCK 0.0058 0.0083 0.0099
Onchocerca volvulus 0.0058 0.0083 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0036 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.0517 1
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Onchocerca volvulus 0.007 0.0109 0.0581
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0058 0.0083 0.0099
Entamoeba histolytica tyrosin kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus regulator of G protein signaling 3 0.0761 0.1588 0.1896
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0079 0.0128 0.0153
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.007 0.0109 0.0109
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis centaurin/arf, putative 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Echinococcus granulosus dynamin 1 0.007 0.0109 0.013
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0055 0.0055
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.007 0.0109 0.013
Brugia malayi ephrin receptor 1 precursor 0.0058 0.0083 0.0083
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0047 0.0047
Plasmodium falciparum oxysterol-binding protein, putative 0.007 0.0109 0.6078
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.007 0.0109 0.6078
Onchocerca volvulus 0.007 0.0109 0.0581
Brugia malayi protein-tyrosine kinase 0.0058 0.0083 0.0083
Brugia malayi Tyrosine-protein kinase abl-1 0.0058 0.0083 0.0083
Echinococcus granulosus titin 0.0024 0.0011 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0761 0.1588 0.1588
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus granulosus tyrosine protein kinase pr2 0.0058 0.0083 0.0099
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.0083 0.0099
Plasmodium vivax PH domain containing protein 0.007 0.0109 0.6078
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.0083 0.0099
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0167 0.0316 0.1993
Echinococcus multilocularis cytohesin 1 0.007 0.0109 0.013
Brugia malayi Oxysterol-binding protein 0.007 0.0109 0.0109
Brugia malayi probable spectrin beta chain 0.007 0.0109 0.0109
Echinococcus multilocularis DCC interacting protein 13 beta 0.007 0.0109 0.013
Trypanosoma cruzi protein kinase, putative 0.0058 0.0083 0.463
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0058 0.0083 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0063 0.0094 0.0112
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3599 0.7656 0.7656
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0042 0.0262
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Echinococcus granulosus retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Entamoeba histolytica receptor protein kinase, putative 0.0058 0.0083 0.0524
Brugia malayi integrin-linked kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0076 0.0123 0.0147
Onchocerca volvulus 0.0898 0.1879 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0089 0.0149 0.8317
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0109 0.0687
Leishmania major protein kinase, putative 0.0076 0.0123 0.6869
Echinococcus granulosus ephrin type A receptor 4 A 0.0058 0.0083 0.0099
Toxoplasma gondii protein kinase domain-containing protein 0.0089 0.0149 0.8317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Echinococcus granulosus cpg binding protein 0.0037 0.0038 0.0046
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0116 0.0207 0.0247
Schistosoma mansoni protein kinase 0.0076 0.0123 0.0123
Echinococcus granulosus tyrosine protein kinase ABL1 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus multilocularis Immunoglobulin 0.0116 0.0207 0.0247
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.0517 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0079 0.0128 0.0805
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica PH domain containing protein 0.007 0.0109 0.0687
Brugia malayi Cadps2 protein 0.007 0.0109 0.0109
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0058 0.0083 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Entamoeba histolytica PH domain containing protein 0.007 0.0109 0.0687
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0058 0.0083 0.0442
Schistosoma mansoni cpg binding protein 0.0035 0.0034 0.0034
Brugia malayi hypothetical protein 0.0761 0.1588 0.1588
Echinococcus granulosus Regulator of G protein signaling 20 0.0761 0.1588 0.1896
Echinococcus granulosus semaphorin 1A 0.0381 0.0774 0.0924
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0063 0.0094 0.0112
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0036 0.2002
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Brugia malayi GTP-ase activating protein for Arf containing protein 0.007 0.0109 0.0109
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0058 0.0083 0.0524
Treponema pallidum NADH oxidase 0.0036 0.0036 0.5
Echinococcus multilocularis rac serine:threonine kinase 0.0089 0.0149 0.0178
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis Pleckstrin y 0.007 0.0109 0.013
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0076 0.0123 0.0147
Leishmania major protein kinase, putative 0.0058 0.0083 0.463
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0058 0.0083 0.0099
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0058 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Blk 0.0058 0.0083 0.0099
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Echinococcus multilocularis beta 1 syntrophin 0.007 0.0109 0.013
Schistosoma mansoni hypothetical protein 0.0029 0.0022 0.0022
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0058 0.0083 0.0099
Echinococcus granulosus tyrosine protein kinase Srms 0.0058 0.0083 0.0099
Echinococcus multilocularis cpg binding protein 0.0037 0.0038 0.0046
Brugia malayi C-terminal src kinase protein 1 0.0058 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0024 0.0011 0.0011
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0123 0.6869
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Brugia malayi Fibronectin type III domain containing protein 0.0121 0.0218 0.0218
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.018 1
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi SH2 domain containing protein 0.0058 0.0083 0.0083
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0036 0.0043
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0058 0.0083 0.0099
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0055 0.0055
Loa Loa (eye worm) AUR protein kinase 0.0079 0.0128 0.0128
Brugia malayi Oxysterol binding protein 0.007 0.0109 0.0109
Trypanosoma cruzi protein kinase, putative 0.0058 0.0083 0.463
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0016 0.0016
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0036 0.0226
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0109 0.6078
Brugia malayi serine/threonine protein kinase 6 0.0079 0.0128 0.0128
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.007 0.0109 0.0109
Leishmania major hypothetical protein, conserved 0.0058 0.0083 0.463
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Echinococcus granulosus integrin linked protein kinase 0.0058 0.0083 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0117 0.0117
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3934 0.8372 0.8372
Schistosoma mansoni rho gtpase activating protein 0.007 0.0109 0.0109
Schistosoma mansoni protein kinase 0.0076 0.0123 0.0123
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Toxoplasma gondii STE kinase 0.0058 0.0083 0.463
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Brugia malayi Dynamin 0.007 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni goodpasture antigen-binding protein 0.007 0.0109 0.0109
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0058 0.0083 0.0099
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0058 0.0083 0.0083
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Entamoeba histolytica hypothetical protein, conserved 0.007 0.0109 0.0687
Echinococcus granulosus regulator of G protein signaling 7 0.0761 0.1588 0.1896
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus raf serine:threonine protein kinase 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis oxysterol binding protein 9 0.007 0.0109 0.013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus cGMP dependent protein kinase 1 0.0024 0.0012 0.0014
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0128 0.0805
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.007 0.0109 0.6078
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0058 0.0083 0.0083
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0023 0.0008 0.0448
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Echinococcus granulosus tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Trypanosoma brucei trypanothione reductase 0.0103 0.018 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0109 0.6078
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0116 0.0207 0.0207
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0128 0.0805
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.0461 0.8918
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0167 0.0316 0.1993
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Toxoplasma gondii phosphatidylinositol transfer protein 0.007 0.0109 0.6078
Echinococcus granulosus transcription factor collier 0.0167 0.0316 0.0378
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.0149 0.0149
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3934 0.8372 1
Onchocerca volvulus 0.0058 0.0083 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.007 0.0109 0.0581
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus multilocularis tyrosine protein kinase pr2 0.0058 0.0083 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Leishmania major protein kinase, putative 0.0024 0.0012 0.0644
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.007 0.0109 0.0687
Loa Loa (eye worm) CAMK protein kinase 0.0024 0.0011 0.0011
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0036 0.2002
Trichomonas vaginalis protein kinase atn1, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/ALK protein kinase 0.0302 0.0605 0.0605
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Protein kinase domain containing protein 0.0302 0.0605 0.0605
Loa Loa (eye worm) AGC/AKT protein kinase 0.0089 0.0149 0.0149
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0036 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0089 0.0149 0.8317
Echinococcus granulosus Pleckstrin y 0.007 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.0083 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Schistosoma mansoni plexin 0.0898 0.1879 0.1879
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Brugia malayi serine/threonine kinase 12 0.0079 0.0128 0.0128
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Plasmodium falciparum glutathione reductase 0.0036 0.0036 0.2002
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Echinococcus multilocularis tyrosine protein kinase Abl 0.0058 0.0083 0.0099
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0083 0.0083
Brugia malayi Probable exocyst complex component Sec5 0.0167 0.0316 0.0316
Trypanosoma brucei Pseudokinase, putative 0.0058 0.0083 0.463
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2054 0.2453
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Echinococcus multilocularis tyrosine protein kinase shark 0.0058 0.0083 0.0099
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0036 0.2002
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Entamoeba histolytica hypothetical protein 0.0089 0.0149 0.0941
Echinococcus multilocularis Pleckstrin y 0.007 0.0109 0.013
Echinococcus granulosus defective proboscis extension response 0.0116 0.0207 0.0247
Echinococcus granulosus oxysterol binding protein 1 0.007 0.0109 0.013
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0058 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis protein kinase 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4695 1 1
Echinococcus granulosus aurora kinase A 0.0079 0.0128 0.0153
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Brugia malayi Raf kinase 0.0058 0.0083 0.0083
Brugia malayi GTP-ase activating protein for Arf containing protein 0.007 0.0109 0.0109
Echinococcus multilocularis tyrosine protein kinase 0.0058 0.0083 0.0099
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK/ROR protein kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0089 0.0149 0.8317
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Plasmodium falciparum protein kinase, putative 0.0058 0.0083 0.463
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Echinococcus granulosus tyrosine kinase 0.0058 0.0083 0.0099
Brugia malayi Guanylyl cyclase protein 23 0.0058 0.0083 0.0083
Leishmania major trypanothione reductase 0.0103 0.018 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0761 0.1588 0.1588
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus multilocularis dynamin 1 0.007 0.0109 0.013
Trypanosoma cruzi NIMA-related kinase, putative 0.0089 0.0149 0.8317
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus multilocularis protein kinase 0.0058 0.0083 0.0099
Loa Loa (eye worm) PH domain-containing protein 0.007 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Loa Loa (eye worm) hypothetical protein 0.0215 0.0419 0.0419
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.007 0.0109 0.0109
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0058 0.0083 0.0099
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.018 1
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) syntrophin-1 0.007 0.0109 0.0109
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus Pleckstrin y 0.007 0.0109 0.013
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.007 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.018 0.018
Toxoplasma gondii AtPH1 family protein 0.007 0.0109 0.6078
Onchocerca volvulus 0.0381 0.0774 0.4118
Echinococcus granulosus tyrosine protein kinase Lyn 0.0076 0.0123 0.0147
Entamoeba histolytica hypothetical protein 0.0167 0.0316 0.1993
Schistosoma mansoni regulator of G protein signaling 0.0761 0.1588 0.1588
Loa Loa (eye worm) glutathione reductase 0.0103 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0058 0.0083 0.0083
Trypanosoma brucei PH domain containing protein, putative 0.007 0.0109 0.6078
Schistosoma mansoni hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Loa Loa (eye worm) RhoGEF domain-containing protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Toxoplasma gondii hypothetical protein 0.007 0.0109 0.6078
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Schistosoma mansoni protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus protein kinase 0.0058 0.0083 0.0099
Plasmodium falciparum cGMP-dependent protein kinase 0.0024 0.0012 0.0644
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0047 0.0047
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Schistosoma mansoni hypothetical protein 0.0494 0.1016 0.1016
Echinococcus granulosus natriuretic peptide receptor 1 0.0058 0.0083 0.0099
Echinococcus multilocularis actin binding protein anillin 0.007 0.0109 0.013
Schistosoma mansoni centaurin alpha 0.007 0.0109 0.0109
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0089 0.0149 0.8317
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni vav2 0.007 0.0109 0.0109
Brugia malayi MAX-1A 0.007 0.0109 0.0109
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Schistosoma mansoni dynamin 0.007 0.0109 0.0109
Entamoeba histolytica protein kinase, putative 0.0079 0.0128 0.0805
Schistosoma mansoni dynamin 0.007 0.0109 0.0109
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Onchocerca volvulus 0.0058 0.0083 0.0442
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis tyrosine kinase 0.0058 0.0083 0.0099
Plasmodium vivax hypothetical protein, conserved 0.007 0.0109 0.6078
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Echinococcus multilocularis raf serine:threonine protein kinase 0.0058 0.0083 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0047 0.0057
Echinococcus granulosus G protein coupled receptor kinase 1 0.2838 0.6028 0.72
Echinococcus granulosus tyrosine kinase 0.0058 0.0083 0.0099
Echinococcus multilocularis regulator of G protein signaling 7 0.0761 0.1588 0.1896
Echinococcus granulosus activated cdc42 kinase 1 0.0058 0.0083 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Mycobacterium tuberculosis Probable reductase 0.0234 0.0461 0.8918
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0058 0.0083 0.0099
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0047 0.0057
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Echinococcus granulosus oxysterol binding protein 9 0.007 0.0109 0.013
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0089 0.0149 0.0941
Echinococcus granulosus twitchin 0.0134 0.0247 0.0295
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Echinococcus multilocularis calcium dependent secretion activator 1 0.007 0.0109 0.013
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Onchocerca volvulus 0.007 0.0109 0.0581
Schistosoma mansoni regulator of G protein signaling 0.0761 0.1588 0.1588
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Entamoeba histolytica ARF GTPase activating protein, putative 0.007 0.0109 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0167 0.0316 0.1993
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0123 0.6869
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0076 0.0123 0.6869
Entamoeba histolytica ankyrin repeat protein 0.0058 0.0083 0.0524
Brugia malayi plexin A 0.1065 0.2236 0.2236
Entamoeba histolytica protein kinase domain containing protein 0.0224 0.044 0.277
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0089 0.0149 0.8317
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Brugia malayi A-kinase anchor protein 10, precursor 0.0761 0.1588 0.1588
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0109 0.0687
Echinococcus multilocularis FL cytokine receptor 0.0058 0.0083 0.0099
Brugia malayi Sema domain containing protein 0.0381 0.0774 0.0774
Brugia malayi Regulator of G protein signaling domain containing protein 0.0761 0.1588 0.1588
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus tyrosine protein kinase csk 0.0058 0.0083 0.0099
Loa Loa (eye worm) RGS-3 protein 0.0761 0.1588 0.1588
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica PH domain containing protein 0.007 0.0109 0.0687
Schistosoma mansoni syntrophin 0.007 0.0109 0.0109
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Tyrosine-protein kinase PR2 0.0058 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase 0.0058 0.0083 0.0099
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Brugia malayi SRC-1 0.0058 0.0083 0.0083
Echinococcus granulosus axis inhibition protein axin 0.0761 0.1588 0.1896
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis protein transport protein sec7, putative 0.007 0.0109 0.0687
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0016 0.0016
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0109 0.6078
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Schistosoma mansoni hypothetical protein 0.0029 0.0022 0.0022
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Immunoglobulin I-set domain containing protein 0.0121 0.0218 0.0218
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/Met protein kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Trichomonas vaginalis centaurin/arf, putative 0.007 0.0109 0.0687
Echinococcus granulosus fibroblast growth factor receptor 4 0.0058 0.0083 0.0099
Brugia malayi hypothetical protein 0.0761 0.1588 0.1588
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.007 0.0109 0.0109
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Onchocerca volvulus 0.007 0.0109 0.0581
Onchocerca volvulus 0.007 0.0109 0.0581
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.007 0.0109 0.6078
Loa Loa (eye worm) RGC/RGC protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis STE family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Entamoeba histolytica hypothetical protein 0.007 0.0109 0.0687
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.0083 0.0099
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0109 0.0687
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0128 0.0805
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Leishmania major protein kinase, putative 0.0089 0.0149 0.8317
Echinococcus granulosus Pleckstrin domain containing protein family B 0.007 0.0109 0.013
Plasmodium falciparum thioredoxin reductase 0.0103 0.018 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0761 0.1588 0.1896
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0121 0.0218 0.0218
Loa Loa (eye worm) TK/EPH protein kinase 0.0058 0.0083 0.0083
Onchocerca volvulus Protein melted homolog 0.007 0.0109 0.0581
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0058 0.0083 0.463
Entamoeba histolytica hypothetical protein 0.0167 0.0316 0.1993
Trypanosoma brucei aurora B kinase 0.0079 0.0128 0.7122
Loa Loa (eye worm) protein kinase domain-containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis insulin receptor 0.0058 0.0083 0.0099
Onchocerca volvulus Putative zinc finger protein 0.007 0.0109 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.007 0.0109 0.013
Schistosoma mansoni serine/threonine-protein kinase 0.0089 0.0151 0.0151
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0898 0.1879 0.1879
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus granulosus Immunoglobulin 0.0116 0.0207 0.0247
Loa Loa (eye worm) TK/ACK protein kinase 0.0058 0.0083 0.0083
Brugia malayi hypothetical protein 0.0058 0.0083 0.0083
Onchocerca volvulus 0.0058 0.0083 0.0442
Schistosoma mansoni regulator of G protein signaling 0.0761 0.1588 0.1588
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Toxoplasma gondii aurora kinase 0.0079 0.0128 0.7122
Schistosoma mansoni serine/threonine protein kinase 0.3599 0.7656 0.7656
Echinococcus granulosus Pleckstrin y 0.007 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Schistosoma mansoni hypothetical protein 0.007 0.0109 0.0109
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0058 0.0083 0.0099
Schistosoma mansoni plexin 0.0517 0.1065 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Schistosoma mansoni hypothetical protein 0.0381 0.0774 0.0774
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0116 0.0207 0.0207
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0012 0.0014
Echinococcus granulosus expressed protein 0.0761 0.1588 0.1896
Leishmania major serine/threonine-protein kinase a, putative 0.0089 0.0149 0.8317
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Echinococcus multilocularis calcium activated potassium channel 0.0021 0.0006 0.0007
Echinococcus multilocularis exocyst complex component 2 0.0167 0.0316 0.0378
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0761 0.1588 1
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0089 0.0149 0.8317
Loa Loa (eye worm) PXA domain-containing protein 0.0761 0.1588 0.1588
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0036 0.5
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus granulosus activin receptor type 0.0076 0.0123 0.0147
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0079 0.0128 0.0805
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0167 0.0316 0.1993
Loa Loa (eye worm) rho-GTPase-activating 0.007 0.0109 0.0109
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0024 0.0012 0.0014
Brugia malayi Receptor family ligand binding region containing protein 0.0058 0.0083 0.0083
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0011 0.0011
Loa Loa (eye worm) uncoordinated protein 104 0.007 0.0109 0.0109
Schistosoma mansoni cpg binding protein 0.0037 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0058 0.0083 0.0099
Toxoplasma gondii protein kinase 0.0058 0.0083 0.463
Echinococcus multilocularis epidermal growth factor receptor 0.0058 0.0083 0.0099
Schistosoma mansoni hypothetical protein 0.0517 0.1065 0.1065
Echinococcus multilocularis axis inhibition protein axin 0.0761 0.1588 0.1896
Trichomonas vaginalis conserved hypothetical protein 0.0761 0.1588 1
Plasmodium falciparum protein kinase, putative 0.0076 0.0123 0.6869
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0089 0.0149 0.8317
Onchocerca volvulus 0.0034 0.0033 0.0177
Echinococcus granulosus oxysterol binding protein 3 0.007 0.0109 0.013
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis integrin linked protein kinase 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.007 0.0109 0.013
Onchocerca volvulus 0.0058 0.0083 0.0442
Trichomonas vaginalis centaurin gamma, putative 0.007 0.0109 0.0687
Toxoplasma gondii Oxysterol-binding protein 0.007 0.0109 0.6078
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica receptor protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Echinococcus multilocularis ephrin type A receptor 4 A 0.0058 0.0083 0.0099
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus MAM 0.0029 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0517 0.1065 0.1065
Echinococcus multilocularis regulator of G protein signaling 3 0.0761 0.1588 0.1896
Brugia malayi hypothetical protein 0.0058 0.0083 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Schistosoma mansoni myotubularin-related protein 0.007 0.0109 0.0109
Echinococcus multilocularis c src tyrosine kinase 0.0058 0.0083 0.0099
Echinococcus multilocularis tyrosine protein kinase Srms 0.0058 0.0083 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Brugia malayi protein unc-22 0.0024 0.0011 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.0181 0.0216
Schistosoma mansoni zinc finger protein 0.007 0.0109 0.0109
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0011 0.0011
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0058 0.0083 0.0099
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0036 0.0036
Echinococcus multilocularis neuroglian 0.0116 0.0207 0.0247
Brugia malayi serine/threonine-protein kinase 6 0.0079 0.0128 0.0128
Echinococcus multilocularis MAM 0.0029 0.0022 0.0027
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0058 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.007 0.0109 0.6078
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0036 0.2002
Leishmania major folate/biopterin transporter, putative 0.0089 0.0149 0.8317
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Echinococcus multilocularis kinase suppressor of Ras 1 0.0058 0.0083 0.0099
Schistosoma mansoni cpg binding protein 0.0037 0.0038 0.0038
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus granulosus tyrosine protein kinase Src64B 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0761 0.1588 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Plasmodium falciparum calcium-dependent protein kinase 7 0.0089 0.0149 0.8317
Brugia malayi hypothetical protein 0.0381 0.0774 0.0774
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0058 0.0083 0.0099
Loa Loa (eye worm) TK/FAK protein kinase 0.0058 0.0083 0.0083
Brugia malayi regulator of G-protein signaling egl-10 0.0761 0.1588 0.1588
Giardia lamblia Kinase, NEK 0.0058 0.0083 0.6501
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0128 0.0805
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0089 0.0149 0.8317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0036 0.2002
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Loa Loa (eye worm) AUR protein kinase 0.0079 0.0128 0.0128
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0042 0.0262
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0058 0.0083 0.0099
Giardia lamblia Kinase, NEK 0.0058 0.0083 0.6501
Loa Loa (eye worm) TK/CSK protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Echinococcus granulosus tyrosine protein kinase shark 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0058 0.0083 0.0083
Echinococcus multilocularis oxysterol binding protein 3 0.007 0.0109 0.013
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0034 0.0034
Entamoeba histolytica cysteine surface protein, putative 0.0058 0.0083 0.0524
Echinococcus multilocularis transcription factor collier 0.0167 0.0316 0.0378
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Echinococcus multilocularis heat shock protein 70 0.0058 0.0083 0.0099
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0058 0.0083 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus granulosus cytohesin 1 0.007 0.0109 0.013
Brugia malayi TBC domain containing protein 0.007 0.0109 0.0109
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0109 0.6078
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica hypothetical protein 0.007 0.0109 0.0687
Brugia malayi Sema domain containing protein 0.0381 0.0774 0.0774
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Brugia malayi IPT/TIG domain containing protein 0.0167 0.0316 0.0316
Schistosoma mansoni regulator of G protein signaling 0.0761 0.1588 0.1588
Plasmodium falciparum protein kinase, putative 0.0058 0.0083 0.463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.0517 1
Trypanosoma cruzi PH domain containing protein, putative 0.007 0.0109 0.6078
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0036 0.0226
Echinococcus granulosus kinase suppressor of Ras 1 0.0058 0.0083 0.0099
Trichomonas vaginalis centaurin beta, putative 0.007 0.0109 0.0687
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Echinococcus multilocularis tyrosine protein kinase HCK 0.0058 0.0083 0.0099
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.0083 0.0099
Entamoeba histolytica cell surface protease gp63, putative 0.0167 0.0316 0.1993
Schistosoma mansoni hypothetical protein 0.0167 0.0316 0.0316
Entamoeba histolytica hypothetical protein, conserved domain containing 0.007 0.0109 0.0687
Loa Loa (eye worm) hypothetical protein 0.0167 0.0316 0.0316
Schistosoma mansoni cell adhesion molecule 0.0121 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Echinococcus multilocularis Ras associated and pleckstrin y 0.007 0.0109 0.013
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.007 0.0109 0.0687
Brugia malayi Variant SH3 domain containing protein 0.007 0.0109 0.0109
Schistosoma mansoni guanyl-nucleotide exchange factor 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.007 0.0109 0.013
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.0181 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0058 0.0083 0.0083
Echinococcus granulosus epidermal growth factor receptor 0.0058 0.0083 0.0099
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Echinococcus granulosus roundabout 2 0.0121 0.0218 0.026
Schistosoma mansoni semaphorin 5-related 0.0381 0.0774 0.0774
Echinococcus multilocularis activin receptor type 0.0076 0.0123 0.0147
Trichomonas vaginalis alpha chimerin, putative 0.007 0.0109 0.0687
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.007 0.0109 0.013
Echinococcus granulosus regulator of G protein signaling 7 0.0761 0.1588 0.1896
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Plasmodium falciparum glutathione reductase 0.0103 0.018 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0167 0.0316 0.0316
Entamoeba histolytica tyrosin kinase, putative 0.0224 0.044 0.277
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3934 0.8372 0.8372
Echinococcus granulosus pleckstrin y domain containing family A 0.007 0.0109 0.013
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0058 0.0083 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Echinococcus multilocularis titin 0.0024 0.0011 0.0013
Echinococcus multilocularis tyrosine protein kinase csk 0.0058 0.0083 0.0099
Giardia lamblia Aurora kinase 0.0079 0.0128 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0012 0.0012
Schistosoma mansoni growth factor receptor-bound protein 0.007 0.0109 0.0109
Echinococcus multilocularis hypothetical protein 0.0381 0.0774 0.0924
Loa Loa (eye worm) TK/ABL protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.007 0.0109 0.0687
Brugia malayi Furin-like cysteine rich region family protein 0.0058 0.0083 0.0083
Schistosoma mansoni serine/threonine RGC 0.0058 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Blk 0.0058 0.0083 0.0099
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0089 0.0149 0.8317
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0058 0.0083 0.0099
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0167 0.0316 0.1993
Brugia malayi glutathione reductase 0.0103 0.018 0.018
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0058 0.0083 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0109 0.0687
Echinococcus multilocularis Rho GTPase activating protein 24 0.007 0.0109 0.013
Echinococcus granulosus neuroglian 0.0116 0.0207 0.0247
Echinococcus granulosus serine/threonine protein kinase 0.0089 0.0149 0.0178
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni ephrin receptor 0.0058 0.0083 0.0083
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Echinococcus multilocularis plexin a4 0.1065 0.2236 0.2671
Echinococcus multilocularis pleckstrin y domain containing family A 0.007 0.0109 0.013
Echinococcus multilocularis pdz domain containing protein 0.007 0.0109 0.013
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Plasmodium vivax glutathione reductase, putative 0.0103 0.018 1
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi CXXC zinc finger family protein 0.0035 0.0034 0.0034
Onchocerca volvulus outspread protein homolog 0.007 0.0109 0.0581
Brugia malayi Plekhf2 protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0381 0.0774 0.0774
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0058 0.0083 0.0524
Echinococcus granulosus beta 1 syntrophin 0.007 0.0109 0.013
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.007 0.0109 0.6078
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0079 0.0128 0.0153
Trichomonas vaginalis hypothetical protein 0.007 0.0109 0.0687
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.007 0.0109 0.6078
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Plasmodium falciparum tyrosine kinase-like protein 0.0058 0.0083 0.463
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0058 0.0083 0.0083
Brugia malayi PXA domain containing protein 0.0761 0.1588 0.1588
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.007 0.0109 0.013
Echinococcus granulosus calcium dependent secretion activator 1 0.007 0.0109 0.013
Brugia malayi hypothetical protein 0.0058 0.0083 0.0083
Onchocerca volvulus 0.007 0.0109 0.0581
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.007 0.0109 0.0687
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Schistosoma mansoni protein kinase 0.0079 0.0128 0.0128
Echinococcus multilocularis expressed protein 0.0761 0.1588 0.1896
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Onchocerca volvulus 0.0035 0.0034 0.0181
Plasmodium falciparum thioredoxin reductase 0.0036 0.0036 0.2002
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus granulosus protein tyrosine kinase 0.0058 0.0083 0.0099
Plasmodium vivax protein kinase, putative 0.0058 0.0083 0.463
Schistosoma mansoni serine/threonine protein kinase 0.3599 0.7656 0.7656
Schistosoma mansoni hypothetical protein 0.007 0.0109 0.0109
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0058 0.0083 0.0083
Brugia malayi hypothetical protein 0.0121 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.0083
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0024 0.0012 0.0644
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0089 0.0149 0.8317
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Plasmodium falciparum PH domain-containing protein, putative 0.007 0.0109 0.6078
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0058 0.0083 0.0083
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0761 0.1588 0.1588
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0058 0.0083 0.0099
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Entamoeba histolytica serine/threonine kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis kinesin light chain, putative 0.007 0.0109 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.0461 0.8918
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0079 0.0128 0.7122
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0036 0.0043
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.007 0.0109 0.013
Echinococcus granulosus calcium activated potassium channel 0.0021 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0167 0.0316 0.0316
Loa Loa (eye worm) SRC-1 0.0058 0.0083 0.0083
Entamoeba histolytica tyrosin kinase, putative 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase, putative 0.0089 0.0149 0.0941
Loa Loa (eye worm) hypothetical protein 0.0116 0.0207 0.0207
Brugia malayi Variant SH3 domain containing protein 0.007 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0058 0.0083 0.0099
Brugia malayi Syntrophin-1 0.007 0.0109 0.0109
Entamoeba histolytica protein kinase , putative 0.0079 0.0128 0.0805
Loa Loa (eye worm) hypothetical protein 0.007 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Loa Loa (eye worm) hypothetical protein 0.0121 0.0218 0.0218
Onchocerca volvulus 0.0058 0.0083 0.0442
Echinococcus multilocularis Oxysterol binding protein 11 0.007 0.0109 0.013
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Entamoeba histolytica hypothetical protein 0.007 0.0109 0.0687
Entamoeba histolytica hypothetical protein 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.0149 0.8317
Brugia malayi Regulator of G protein signaling domain containing protein 0.0761 0.1588 0.1588
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0036 0.2002
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0058 0.0083 0.0083
Loa Loa (eye worm) Plekhf2 protein 0.007 0.0109 0.0109
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0167 0.0316 0.1993
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0036 0.2002
Onchocerca volvulus 0.0029 0.0022 0.0119
Plasmodium vivax tyrosine kinase-like protein, putative 0.0058 0.0083 0.463
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.0316 0.1993
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0058 0.0083 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Schistosoma mansoni oxysterol-binding protein 1 0.007 0.0109 0.0109
Entamoeba histolytica PH domain containing protein kinase, putative 0.0089 0.0149 0.0941
Toxoplasma gondii protein kinase domain-containing protein 0.0058 0.0083 0.463
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis TKL family protein kinase 0.0058 0.0083 0.0524
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0058 0.0083 0.0524
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0089 0.0149 0.8317
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0036 1
Schistosoma mansoni serine/threonine protein kinase 0.4695 1 1
Leishmania major hypothetical protein, conserved 0.007 0.0109 0.6078
Brugia malayi Protein kinase domain containing protein 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0109 0.0687
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2838 0.6028 0.72
Schistosoma mansoni axis inhibition protein axin 0.0761 0.1588 0.1588
Echinococcus multilocularis semaphorin 5B 0.0381 0.0774 0.0924
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0058 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0058 0.0083 0.0524
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Loa Loa (eye worm) TK/FER protein kinase 0.0058 0.0083 0.0083
Schistosoma mansoni tyrosine protein kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.0149 0.8317
Echinococcus granulosus myotubularin protein 13 0.007 0.0109 0.013
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0173 0.033 0.033
Echinococcus granulosus exocyst complex component 2 0.0167 0.0316 0.0378
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Loa Loa (eye worm) TK protein kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0089 0.0149 0.8317
Schistosoma mansoni hypothetical protein 0.0381 0.0774 0.0774
Schistosoma mansoni nephrin 0.0121 0.0218 0.0218
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0058 0.0083 0.0442
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Echinococcus granulosus axis inhibition protein axin 0.0761 0.1588 0.1896
Loa Loa (eye worm) sema domain-containing protein 0.0381 0.0774 0.0774
Echinococcus multilocularis regulator of G protein signaling 3 0.0761 0.1588 0.1896
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0058 0.0083 0.0524
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0089 0.0149 0.0941
Schistosoma mansoni tyrosine kinase 0.0058 0.0083 0.0083
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0058 0.0083 0.0099
Entamoeba histolytica tyrosine kinase, putative 0.0058 0.0083 0.0524
Brugia malayi PH domain containing protein 0.007 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.007 0.0109 0.013
Trichomonas vaginalis AGC family protein kinase 0.0089 0.0149 0.0941
Loa Loa (eye worm) TK/EGFR protein kinase 0.0058 0.0083 0.0083
Trypanosoma cruzi hypothetical protein 0.007 0.0109 0.6078
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0079 0.0128 0.0805
Loa Loa (eye worm) hypothetical protein 0.0761 0.1588 0.1588
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0083 0.0524
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0083 0.0524
Schistosoma mansoni oxysterol-binding protein 1 0.007 0.0109 0.0109
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.007 0.0109 0.0581

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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