Detailed information for compound 1389531

Basic information

Technical information
  • TDR Targets ID: 1389531
  • Name: 1-[4-acetyl-1-[4-(3,4-dimethylphenyl)-5-methy l-1,3-thiazol-2-yl]-2,5-dimethylpyrrol-3-yl]e thanone
  • MW: 380.503 | Formula: C22H24N2O2S
  • H donors: 0 H acceptors: 3 LogP: 4.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1sc(nc1c1ccc(c(c1)C)C)n1c(C)c(c(c1C)C(=O)C)C(=O)C
  • InChi: 1S/C22H24N2O2S/c1-11-8-9-18(10-12(11)2)21-17(7)27-22(23-21)24-13(3)19(15(5)25)20(14(24)4)16(6)26/h8-10H,1-7H3
  • InChiKey: QSTKZQMKZVLIPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-acetyl-1-[4-(3,4-dimethylphenyl)-5-methyl-thiazol-2-yl]-2,5-dimethyl-pyrrol-3-yl]ethanone
  • 1-[4-acetyl-1-[4-(3,4-dimethylphenyl)-5-methyl-2-thiazolyl]-2,5-dimethyl-3-pyrrolyl]ethanone
  • 1-[1-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-4-ethanoyl-2,5-dimethyl-pyrrol-3-yl]ethanone
  • ZINC00807675
  • 1-{4-Acetyl-1-[4-(3,4-dimethyl-phenyl)-5-methyl-thiazol-2-yl]-2,5-dimethyl-1H-pyrrol-3-yl}-ethanone
  • MLS000067895
  • BAS 07248926
  • SMR000122469

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus transcription factor collier 0.0105 0.0243 0.029
Entamoeba histolytica hypothetical protein 0.0523 0.1549 1
Echinococcus multilocularis dynamin 1 0.0048 0.0063 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0036 0.0027 0.0032
Onchocerca volvulus 0.0036 0.0027 0.0161
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Brugia malayi hypothetical protein 0.0241 0.0666 0.0666
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus fibroblast growth factor receptor 4 0.0036 0.0027 0.0032
Trypanosoma cruzi aurora B kinase, putative 0.0073 0.014 1
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni plexin 0.0563 0.1672 0.1672
Echinococcus granulosus pdz domain containing protein 0.0048 0.0063 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0124 0.0124
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Echinococcus multilocularis cytohesin 1 0.0048 0.0063 0.0076
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0048 0.0063 0.0076
Echinococcus granulosus tyrosine kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Plasmodium falciparum serine/threonine protein kinase, putative 0.0073 0.014 1
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0036 0.0027 0.0032
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Onchocerca volvulus 0.0036 0.0027 0.0161
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0048 0.0063 0.0076
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0063 0.0063
Loa Loa (eye worm) TK/DDR protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus pleckstrin y domain containing family A 0.0048 0.0063 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0124
Schistosoma mansoni cell adhesion molecule 0.0067 0.0124 0.0124
Brugia malayi intermediate filament protein 0.0033 0.0015 0.0015
Loa Loa (eye worm) TK/ACK protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus intermediate filament protein 0.0033 0.0015 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0563 0.1672 0.1672
Schistosoma mansoni zinc finger protein 0.0048 0.0063 0.0063
Echinococcus granulosus protein tyrosine kinase 0.0036 0.0027 0.0032
Schistosoma mansoni dynamin 0.0048 0.0063 0.0063
Brugia malayi Dynamin 0.0048 0.0063 0.0063
Brugia malayi Cadps2 protein 0.0048 0.0063 0.0063
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis neuroglian 0.0063 0.0109 0.013
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0048 0.0063 0.0063
Onchocerca volvulus 0.0048 0.0063 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0073 0.014 0.0754
Echinococcus granulosus semaphorin 1A 0.0241 0.0666 0.0796
Entamoeba histolytica PH domain containing protein 0.0048 0.0063 0.024
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0027 0.0032
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Onchocerca volvulus 0.0033 0.0015 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Onchocerca volvulus Putative zinc finger protein 0.0048 0.0063 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Loa Loa (eye worm) hypothetical protein 0.0105 0.0243 0.0243
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Schistosoma mansoni fibrocystin l 0.0105 0.0243 0.0243
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0063 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) PXA domain-containing protein 0.0523 0.1549 0.1549
Echinococcus granulosus aurora kinase A 0.0073 0.014 0.0167
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0104 0.0104
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0105 0.0243 0.1429
Schistosoma mansoni vesicular amine transporter 0.0065 0.0117 0.0117
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0048 0.0063 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0049 0.0049
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0027 0.0027
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0063 0.0063
Echinococcus multilocularis GRB2 associated binding protein 3 0.0048 0.0063 0.0076
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0322 0.092 0.092
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis tyrosine protein kinase shark 0.0036 0.0027 0.0032
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0061 0.0104 0.6834
Brugia malayi Probable exocyst complex component Sec5 0.0105 0.0243 0.0243
Trypanosoma brucei protein kinase, putative 0.0049 0.0068 0.3608
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0063
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0048 0.0063 0.0379
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Echinococcus granulosus Oxysterol binding protein 11 0.0048 0.0063 0.0076
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0048 0.0063 0.0251
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0027 0.0027
Echinococcus multilocularis hypothetical protein 0.0241 0.0666 0.0796
Loa Loa (eye worm) TK/EGFR protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0061 0.0104 0.6834
Entamoeba histolytica hypothetical protein 0.0061 0.0104 0.0509
Schistosoma mansoni protein kinase 0.0049 0.0068 0.0068
Leishmania major protein kinase, putative 0.0061 0.0104 0.6834
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0523 0.1549 0.1549
Brugia malayi hypothetical protein 0.0036 0.0027 0.0027
Trypanosoma cruzi NIMA-related kinase, putative 0.0061 0.0104 0.6834
Echinococcus granulosus axis inhibition protein axin 0.0523 0.1549 0.1851
Echinococcus multilocularis regulator of G protein signaling 3 0.0523 0.1549 0.1851
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0104 0.6834
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Onchocerca volvulus 0.0036 0.0027 0.0161
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2704 0.8365 0.8365
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0063 0.0109 0.013
Plasmodium falciparum oxysterol-binding protein, putative 0.0048 0.0063 0.3226
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0147
Echinococcus granulosus DCC interacting protein 13 beta 0.0048 0.0063 0.0076
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0147
Brugia malayi Sema domain containing protein 0.0241 0.0666 0.0666
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0063 0.0251
Brugia malayi integrin-linked kinase 0.0036 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0048 0.0063 0.024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi hypothetical protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0286 0.0806 0.0806
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis Rho GTPase activating protein 24 0.0048 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Brugia malayi hypothetical protein 0.0241 0.0666 0.0666
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0063
Schistosoma mansoni ephrin receptor 0.0036 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0063 0.3226
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0048 0.0063 0.0076
Echinococcus granulosus myotubularin protein 13 0.0048 0.0063 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Echinococcus multilocularis pdz domain containing protein 0.0048 0.0063 0.0076
Loa Loa (eye worm) TK/Met protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0099 0.0222 0.0222
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0048 0.0063 0.0379
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0027 0.0032
Echinococcus granulosus insulin receptor 0.0036 0.0027 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.2474 0.7645 0.7645
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis regulator of G protein signaling 0.0523 0.1549 0.1851
Trichomonas vaginalis STE family protein kinase 0.0036 0.0027 0.0011
Leishmania major hypothetical protein, conserved 0.0048 0.0063 0.3226
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0061 0.0104 0.0519
Echinococcus granulosus GRB2 associated binding protein 3 0.0048 0.0063 0.0076
Brugia malayi Protein kinase domain containing protein 0.0268 0.0751 0.0751
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0036 0.0027 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2704 0.8365 0.8365
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0015 0.0015
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0063 0.0063
Echinococcus granulosus oxysterol binding protein 9 0.0048 0.0063 0.0076
Leishmania major protein kinase, putative 0.0073 0.014 1
Toxoplasma gondii protein kinase domain-containing protein 0.0061 0.0104 0.6834
Echinococcus multilocularis tyrosine protein kinase Abl 0.0036 0.0027 0.0032
Onchocerca volvulus 0.0036 0.0027 0.0161
Onchocerca volvulus 0.0036 0.0027 0.0161
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Entamoeba histolytica hypothetical protein 0.0523 0.1549 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0058 0.0095 0.0095
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.0063 0.0063
Echinococcus multilocularis activated cdc42 kinase 1 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0036 0.0027 0.0032
Echinococcus multilocularis lamin dm0 0.0033 0.0015 0.0018
Echinococcus multilocularis Immunoglobulin 0.0063 0.0109 0.013
Echinococcus multilocularis roundabout 2 0.0067 0.0124 0.0148
Brugia malayi TBC domain containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Loa Loa (eye worm) SRC-1 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0048 0.0063 0.0379
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.0073 0.014 0.0744
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus regulator of G protein signaling 3 0.0523 0.1549 0.1851
Echinococcus granulosus kinase suppressor of Ras 1 0.0036 0.0027 0.0032
Entamoeba histolytica hypothetical protein, conserved 0.0048 0.0063 0.024
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Fibronectin type III domain containing protein 0.0067 0.0124 0.0124
Loa Loa (eye worm) TK/EPH protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis Regulator of G protein signaling 20 0.0523 0.1549 0.1851
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0523 0.1549 0.1549
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.0356 0.2166
Trichomonas vaginalis protein tyrosine kinase, putative 0.0036 0.0027 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0241 0.0666 0.0666
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0036 0.0027 0.0032
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Onchocerca volvulus outspread protein homolog 0.0048 0.0063 0.0379
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0036 0.0027 0.0032
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0068 0.3608
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Brugia malayi IPT/TIG domain containing protein 0.0105 0.0243 0.0243
Echinococcus granulosus tyrosine kinase 0.0036 0.0027 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trypanosoma brucei rac serine-threonine kinase, putative 0.0061 0.0104 0.6834
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0036 0.0027 0.0032
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1659 0.1983
Schistosoma mansoni lamin 0.0033 0.0015 0.0015
Brugia malayi ephrin receptor 1 precursor 0.0036 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis centaurin gamma, putative 0.0048 0.0063 0.0251
Echinococcus multilocularis regulator of G protein signaling 7 0.0523 0.1549 0.1851
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0063 0.0251
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0036 0.0027 0.0027
Brugia malayi protein-tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi hypothetical protein 0.0523 0.1549 0.1549
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Toxoplasma gondii aurora kinase 0.0073 0.014 1
Schistosoma mansoni dynamin 0.0048 0.0063 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Echinococcus multilocularis axis inhibition protein axin 0.0523 0.1549 0.1851
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0061 0.0104 0.6834
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trypanosoma cruzi NIMA-related kinase, putative 0.0061 0.0104 0.6834
Echinococcus granulosus lamin dm0 0.0033 0.0015 0.0018
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0105 0.0243 0.0243
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0027 0.0032
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0036 0.0027 0.0032
Trichomonas vaginalis kinesin light chain, putative 0.0048 0.0063 0.0251
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Echinococcus granulosus regulator of G protein signaling 7 0.0523 0.1549 0.1851
Echinococcus multilocularis Pleckstrin y 0.0048 0.0063 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0105 0.0243 0.1429
Echinococcus multilocularis pleckstrin y domain containing family A 0.0048 0.0063 0.0076
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0027 0.0032
Entamoeba histolytica protein kinase , putative 0.0073 0.014 0.0744
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0061 0.0104 0.6834
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis axis inhibition protein axin 0.0523 0.1549 0.1851
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0036 0.0027 0.0011
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0027 0.0032
Brugia malayi Tyrosine-protein kinase PR2 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0048 0.0063 0.0379
Loa Loa (eye worm) oxysterol binding protein 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0044 0.0044
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0073 0.014 0.0744
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0061 0.0104 0.6834
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0036 0.0027 0.0032
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0027 0.0032
Brugia malayi Receptor family ligand binding region containing protein 0.0036 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0048 0.0063 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Brugia malayi probable spectrin beta chain 0.0048 0.0063 0.0063
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0036 0.0027 0.0161
Echinococcus multilocularis beta adrenergic receptor kinase 0.2474 0.7645 0.914
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0027 0.0032
Brugia malayi Oxysterol binding protein 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Srms 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis hypothetical protein 0.0048 0.0063 0.0251
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0036 0.0027 0.0032
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0068 0.3608
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Onchocerca volvulus 0.0048 0.0063 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.014 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Loa Loa (eye worm) AUR protein kinase 0.0073 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Toxoplasma gondii phosphatidylinositol transfer protein 0.0048 0.0063 0.3226
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0036 0.0027 0.0032
Echinococcus multilocularis oxysterol binding protein 3 0.0048 0.0063 0.0076
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0048 0.0063 0.0251
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Entamoeba histolytica ARF GTPase activating protein, putative 0.0048 0.0063 0.024
Brugia malayi PXA domain containing protein 0.0523 0.1549 0.1549
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase pr2 0.0036 0.0027 0.0032
Onchocerca volvulus Tyrosine kinase homolog 0.0036 0.0027 0.0161
Schistosoma mansoni protein kinase 0.0049 0.0068 0.0068
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.0063 0.0076
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Echinococcus multilocularis tyrosine kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0015 0.0015
Onchocerca volvulus 0.0563 0.1672 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni intermediate filament proteins 0.0033 0.0015 0.0015
Brugia malayi C-terminal src kinase protein 1 0.0036 0.0027 0.0027
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0048 0.0063 0.0076
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0048 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Dynamin 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0063 0.0109 0.0109
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0068 0.0269
Echinococcus multilocularis receptor type guanylyl cyclase 0.0036 0.0027 0.0032
Echinococcus multilocularis natriuretic peptide receptor 1 0.0036 0.0027 0.0032
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0523 0.1549 0.1851
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni myotubularin-related protein 0.0048 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Brugia malayi serine/threonine-protein kinase 6 0.0073 0.014 0.014
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni protein kinase 0.0073 0.014 0.014
Echinococcus multilocularis Immunoglobulin 0.0063 0.0109 0.013
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0036 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0048 0.0063 0.3226
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0061 0.0104 0.6834
Entamoeba histolytica hypothetical protein 0.0105 0.0243 0.142
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Schistosoma mansoni ephrin receptor 0.0041 0.0042 0.0042
Trypanosoma brucei aurora B kinase 0.0073 0.014 1
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus defective proboscis extension response 0.0063 0.0109 0.013
Brugia malayi Sema domain containing protein 0.0241 0.0666 0.0666
Trichomonas vaginalis protein kinase atn1, putative 0.0036 0.0027 0.0011
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0105 0.0243 0.142
Echinococcus multilocularis integrin linked protein kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Brugia malayi MAX-1A 0.0048 0.0063 0.0063
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Onchocerca volvulus 0.0036 0.0027 0.0161
Brugia malayi hypothetical protein 0.0043 0.0049 0.0049
Leishmania major serine/threonine-protein kinase a, putative 0.0061 0.0104 0.6834
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0073 0.014 0.0744
Trichomonas vaginalis AGC family protein kinase 0.0073 0.014 0.0754
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis protein kinase 0.0036 0.0027 0.0032
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0523 0.1549 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Brugia malayi hypothetical protein 0.0048 0.0063 0.0063
Echinococcus granulosus natriuretic peptide receptor 1 0.0036 0.0027 0.0032
Loa Loa (eye worm) protein kinase domain-containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Brugia malayi Uncoordinated protein 104 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Echinococcus multilocularis Ras associated and pleckstrin y 0.0048 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0036 0.0027 0.0161
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Brugia malayi Cytohesin 3 0.0048 0.0063 0.0063
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0241 0.0666 0.0666
Echinococcus granulosus activated cdc42 kinase 1 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Loa Loa (eye worm) PH domain-containing protein 0.0048 0.0063 0.0063
Leishmania major protein kinase, putative 0.0049 0.0068 0.3608
Brugia malayi Regulator of G protein signaling domain containing protein 0.0523 0.1549 0.1549
Echinococcus multilocularis beta 1 syntrophin 0.0048 0.0063 0.0076
Echinococcus multilocularis musashi 0.0033 0.0015 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0049 0.0068 0.0081
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0095 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Brugia malayi hypothetical protein 0.0036 0.0027 0.0027
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0041 0.0042 0.005
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0048 0.0063 0.0076
Brugia malayi Syntrophin-1 0.0048 0.0063 0.0063
Echinococcus granulosus axis inhibition protein axin 0.0523 0.1549 0.1851
Brugia malayi PXA domain containing protein 0.0523 0.1549 0.1549
Loa Loa (eye worm) TK/ROR protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus protein kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) serine/threonine protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0027 0.0027
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0061 0.0104 0.6834
Echinococcus multilocularis actin binding protein anillin 0.0048 0.0063 0.0076
Schistosoma mansoni regulator of G protein signaling 0.0523 0.1549 0.1549
Schistosoma mansoni regulator of G protein signaling 0.0523 0.1549 0.1549
Schistosoma mansoni hypothetical protein 0.0105 0.0243 0.0243
Loa Loa (eye worm) cytohesin 3 0.0048 0.0063 0.0063
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0036 0.0027 0.0027
Echinococcus multilocularis transcription factor collier 0.0105 0.0243 0.029
Brugia malayi hypothetical protein 0.0523 0.1549 0.1549
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) sema domain-containing protein 0.0241 0.0666 0.0666
Brugia malayi DNA-binding protein LAG-1 0.0105 0.0243 0.0243
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Brugia malayi Plekhf2 protein 0.0048 0.0063 0.0063
Echinococcus granulosus Immunoglobulin 0.0063 0.0109 0.013
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0073 0.014 1
Echinococcus granulosus roundabout 2 0.0067 0.0124 0.0148
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus dynamin 1 0.0048 0.0063 0.0076
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0063 0.024
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0048 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus granulosus cytohesin 1 0.0048 0.0063 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0063 0.3226
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi Guanylyl cyclase protein 23 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0036 0.0027 0.0161
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0049 0.0068 0.0081
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0068 0.0081
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0073 0.014 0.0744
Brugia malayi Regulator of G protein signaling domain containing protein 0.0523 0.1549 0.1549
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0027 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Giardia lamblia Aurora kinase 0.0073 0.014 1
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) TK/CSK protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0063 0.0251
Echinococcus granulosus oxysterol binding protein 3 0.0048 0.0063 0.0076
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Brugia malayi serine/threonine kinase 12 0.0073 0.014 0.014
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0048 0.0063 0.3226
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Entamoeba histolytica cell surface protease gp63, putative 0.0105 0.0243 0.142
Echinococcus multilocularis raf serine:threonine protein kinase 0.0036 0.0027 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0033 0.004
Schistosoma mansoni serine/threonine-protein kinase 0.0061 0.0104 0.0104
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0523 0.1549 0.1549
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Onchocerca volvulus 0.0058 0.0095 0.0571
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0124
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0061 0.0104 0.6834
Schistosoma mansoni syntrophin 0.0048 0.0063 0.0063
Schistosoma mansoni tyrosine protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Toxoplasma gondii hypothetical protein 0.0048 0.0063 0.3226
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0048 0.0063 0.0076
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0017 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK/ALK protein kinase 0.0268 0.075 0.075
Echinococcus granulosus beta-adrenergic receptor kinase 0.2474 0.7645 0.914
Echinococcus granulosus plexin a4 0.0668 0.2002 0.2393
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni plexin 0.0322 0.092 0.092
Schistosoma mansoni regulator of G protein signaling 0.0523 0.1549 0.1549
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) AUR protein kinase 0.0073 0.014 0.014
Onchocerca volvulus 0.0241 0.0666 0.3981
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0036 0.0027 0.0027
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0061 0.0104 0.6834
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0015 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0048 0.0063 0.0076
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1659 0.1983
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0105 0.0243 0.1429
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0061 0.0104 0.0509
Echinococcus granulosus receptor type guanylyl cyclase 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0063 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) rho-GTPase-activating 0.0048 0.0063 0.0063
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0041 0.0042 0.005
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3227 1 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0523 0.1549 0.1549
Echinococcus granulosus calcium dependent secretion activator 1 0.0048 0.0063 0.0076
Brugia malayi hypothetical protein 0.0067 0.0124 0.0124
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Echinococcus multilocularis FL cytokine receptor 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Entamoeba histolytica hypothetical protein 0.0048 0.0063 0.024
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0027 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0049 0.0059
Onchocerca volvulus 0.0036 0.0027 0.0161
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2474 0.7645 0.7645
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) AGC/AKT protein kinase 0.0061 0.0104 0.0104
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0061 0.0104 0.6834
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0063 0.024
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni regulator of G protein signaling 0.0523 0.1549 0.1549
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0063 0.0251
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Onchocerca volvulus Protein melted homolog 0.0048 0.0063 0.0379
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Plasmodium falciparum PH domain-containing protein, putative 0.0048 0.0063 0.3226
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis transfer RNA-Thr 0.0036 0.0027 0.0032
Echinococcus multilocularis exocyst complex component 2 0.0105 0.0243 0.029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0033 0.004
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0061 0.0104 0.6834
Echinococcus granulosus tyrosine protein kinase 0.0036 0.0027 0.0032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0048 0.0063 0.0063
Brugia malayi bone morphogenetic protein type 1 receptor 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0027 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0061 0.0104 0.6834
Brugia malayi Protein kinase domain containing protein 0.0061 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus granulosus tyrosine kinase 0.0036 0.0027 0.0032
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis oxysterol binding protein 9 0.0048 0.0063 0.0076
Echinococcus multilocularis ephrin type A receptor 4 A 0.0036 0.0027 0.0032
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0063 0.024
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus Rho GTPase activating protein 24 0.0048 0.0063 0.0076
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0147
Echinococcus granulosus integrin linked protein kinase 0.0036 0.0027 0.0032
Schistosoma mansoni centaurin alpha 0.0048 0.0063 0.0063
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0043 0.0049 0.0049
Echinococcus multilocularis Pleckstrin y 0.0048 0.0063 0.0076
Echinococcus granulosus serine/threonine protein kinase 0.0061 0.0104 0.0125
Echinococcus multilocularis Oxysterol binding protein 11 0.0048 0.0063 0.0076
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0036 0.0027 0.0032
Leishmania major folate/biopterin transporter, putative 0.0061 0.0104 0.6834
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0036 0.0027 0.0032
Brugia malayi Furin-like cysteine rich region family protein 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0063 0.0109 0.0109
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0027 0.0032
Trichomonas vaginalis centaurin alpha, putative 0.0048 0.0063 0.0251
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Echinococcus multilocularis lamin 0.0033 0.0015 0.0018
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0027 0.0032
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus multilocularis expressed protein 0.0523 0.1549 0.1851
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0036 0.0027 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus Pleckstrin y 0.0048 0.0063 0.0076
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0105 0.0243 0.1429
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0806 0.0963
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus granulosus semaphorin 5B 0.0241 0.0666 0.0796
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0806 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0048 0.0063 0.0251
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus regulator of G protein signaling 3 0.0523 0.1549 0.1851
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0044 0.0044
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0027 0.0027
Trypanosoma brucei protein kinase, putative 0.0061 0.0104 0.6834
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0048 0.0063 0.0063
Onchocerca volvulus 0.0048 0.0063 0.0379
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni lamin 0.0033 0.0015 0.0015
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Echinococcus multilocularis protein tyrosine kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.0013 0.0013
Echinococcus granulosus tyrosine protein kinase pr2 0.0036 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.0036 0.0027 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Loa Loa (eye worm) AUR protein kinase 0.0073 0.014 0.014
Trichomonas vaginalis centaurin beta, putative 0.0048 0.0063 0.0251
Echinococcus granulosus G protein coupled receptor kinase 1 0.195 0.601 0.7185
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0063 0.0251
Echinococcus granulosus activin receptor type 0.0049 0.0068 0.0081
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0048 0.0063 0.0076
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0061 0.0104 0.6834
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0036 0.0027 0.0011
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0061 0.0104 0.0519
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0048 0.0063 0.3226
Echinococcus granulosus regulator of G protein signaling 7 0.0523 0.1549 0.1851
Echinococcus multilocularis protein kinase 0.0036 0.0027 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.3227 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Loa Loa (eye worm) TK/FER protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0048 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0049 0.0059
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Echinococcus granulosus lamin 0.0033 0.0015 0.0018
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TK family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni hypothetical protein 0.0105 0.0243 0.0243
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0063 0.024
Toxoplasma gondii AtPH1 family protein 0.0048 0.0063 0.3226
Toxoplasma gondii Oxysterol-binding protein 0.0048 0.0063 0.3226
Schistosoma mansoni survival motor neuron protein 0.0058 0.0095 0.0095
Loa Loa (eye worm) TK/RYK protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus raf serine:threonine protein kinase 0.0036 0.0027 0.0032
Trypanosoma cruzi Protein kinase B 0.0061 0.0104 0.6834
Echinococcus granulosus oxysterol binding protein 1 0.0048 0.0063 0.0076
Echinococcus granulosus epidermal growth factor receptor 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0241 0.0666 0.0666
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi plexin A 0.0668 0.2002 0.2002
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Brugia malayi A-kinase anchor protein 10, precursor 0.0523 0.1549 0.1549
Echinococcus multilocularis calcium dependent secretion activator 1 0.0048 0.0063 0.0076
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0063 0.0063
Loa Loa (eye worm) plexin A 0.0668 0.2002 0.2002
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus tyrosine protein kinase ABL1 0.0036 0.0027 0.0032
Echinococcus granulosus tyrosine protein kinase shark 0.0036 0.0027 0.0032
Echinococcus multilocularis regulator of G protein signaling 3 0.0523 0.1549 0.1851
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0061 0.0104 0.6834
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0061 0.0104 0.6834
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus twitchin 0.0076 0.015 0.0179
Onchocerca volvulus 0.0036 0.0027 0.0161
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0036 0.0027 0.0032
Echinococcus granulosus Pleckstrin y 0.0048 0.0063 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Onchocerca volvulus 0.0048 0.0063 0.0379
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0036 0.0027 0.0032
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0027 0.0032
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0048 0.0063 0.0379
Echinococcus multilocularis rac serine:threonine kinase 0.0061 0.0104 0.0125
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0063 0.0063
Brugia malayi Raf kinase 0.0036 0.0027 0.0027
Trypanosoma brucei PH domain containing protein, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis kinase suppressor of Ras 1 0.0036 0.0027 0.0032
Echinococcus multilocularis plexin a4 0.0668 0.2002 0.2393
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.0063 0.0076
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0063 0.0109 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0105 0.0243 0.142
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0027 0.0032
Echinococcus granulosus ephrin type A receptor 4 A 0.0036 0.0027 0.0032
Echinococcus granulosus Pleckstrin y 0.0048 0.0063 0.0076
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0063 0.0063
Brugia malayi hypothetical protein 0.0286 0.0806 0.0806
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trichomonas vaginalis alpha chimerin, putative 0.0048 0.0063 0.0251
Entamoeba histolytica protein kinase domain containing protein 0.0073 0.014 0.0744
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0015 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0061 0.0104 0.0509
Brugia malayi Tyrosine-protein kinase abl-1 0.0036 0.0027 0.0027
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) RGS-3 protein 0.0523 0.1549 0.1549
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi SH2 domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus expressed protein 0.0523 0.1549 0.1851
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0063 0.0251
Echinococcus multilocularis insulin receptor 0.0036 0.0027 0.0032
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis DCC interacting protein 13 beta 0.0048 0.0063 0.0076
Echinococcus multilocularis protein KINase family member (kin 25) 0.0036 0.0027 0.0032
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Echinococcus granulosus Regulator of G protein signaling 20 0.0523 0.1549 0.1851
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni vav2 0.0048 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis tyrosine protein kinase 0.0036 0.0027 0.0032
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0048 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0523 0.1549 1
Entamoeba histolytica tyrosin kinase, putative 0.0142 0.0356 0.2166
Toxoplasma gondii hypothetical protein 0.0048 0.0063 0.3226
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0063 0.0063
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Schistosoma mansoni protein tyrosine kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0036 0.0027 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0036 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0036 0.0027 0.0032
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2704 0.8365 1
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.0061 0.0104 0.0509
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2704 0.8365 1
Trypanosoma cruzi hypothetical protein 0.0048 0.0063 0.3226
Echinococcus granulosus beta 1 syntrophin 0.0048 0.0063 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Entamoeba histolytica hypothetical protein 0.0048 0.0063 0.024
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0048 0.0063 0.0076
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis activin receptor type 0.0049 0.0068 0.0081
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0036 0.0027 0.0011
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0036 0.0027 0.0161
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0063 0.0063
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0523 0.1549 0.1851
Brugia malayi PH domain containing protein 0.0048 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0048 0.0063 0.0063
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0049 0.0068 0.3608
Loa Loa (eye worm) sema domain-containing protein 0.0241 0.0666 0.0666
Loa Loa (eye worm) uncoordinated protein 104 0.0048 0.0063 0.0063
Brugia malayi regulator of G-protein signaling rgs-7 0.0523 0.1549 0.1549
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Leishmania major protein kinase, putative 0.0061 0.0104 0.6834
Schistosoma mansoni semaphorin 5-related 0.0241 0.0666 0.0666
Brugia malayi Plexin repeat family protein 0.0563 0.1672 0.1672
Echinococcus multilocularis tyrosine kinase 0.0036 0.0027 0.0032
Onchocerca volvulus 0.0036 0.0027 0.0161
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0073 0.014 0.0167
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1659 0.1983
Schistosoma mansoni rho gtpase activating protein 0.0048 0.0063 0.0063
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Brugia malayi SRC-1 0.0036 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Src64B 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0243 0.1429
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0036 0.0027 0.0032
Echinococcus multilocularis G protein coupled receptor kinase 1 0.195 0.601 0.7185
Echinococcus multilocularis oxysterol binding protein 1 0.0048 0.0063 0.0076
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0048 0.0063 0.0251
Onchocerca volvulus 0.0036 0.0027 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0063 0.0251
Echinococcus multilocularis epidermal growth factor receptor 0.0036 0.0027 0.0032
Entamoeba histolytica p21-activated kinase 0.0061 0.0104 0.0509
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Loa Loa (eye worm) Plekhf2 protein 0.0048 0.0063 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0048 0.0063 0.3226
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0063 0.3226
Onchocerca volvulus 0.0033 0.0015 0.009
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0048 0.0063 0.3226
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2704 0.8365 0.8365
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Loa Loa (eye worm) TK/FAK protein kinase 0.0036 0.0027 0.0027
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0048 0.0063 0.0076
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0048 0.0063 0.3226
Brugia malayi SH2 domain containing protein 0.0036 0.0027 0.0027
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0073 0.014 0.0167
Echinococcus multilocularis Pleckstrin y 0.0048 0.0063 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni zinc finger protein 0.0048 0.0063 0.0063
Trypanosoma cruzi PH domain containing protein, putative 0.0048 0.0063 0.3226
Trichomonas vaginalis AGC family protein kinase 0.0073 0.014 0.0754
Entamoeba histolytica PH domain containing protein 0.0048 0.0063 0.024
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0027 0.0027
Loa Loa (eye worm) syntrophin-1 0.0048 0.0063 0.0063
Loa Loa (eye worm) RGC/RGC protein kinase 0.0036 0.0027 0.0027
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0048 0.0063 0.3226
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0048 0.0063 0.0076
Brugia malayi serine/threonine protein kinase 6 0.0073 0.014 0.014
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0036 0.0027 0.0027
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0036 0.0027 0.0027
Echinococcus multilocularis regulator of G protein signaling 7 0.0523 0.1549 0.1851
Loa Loa (eye worm) hypothetical protein 0.0105 0.0243 0.0243
Brugia malayi regulator of G-protein signaling egl-10 0.0523 0.1549 0.1549
Entamoeba histolytica hypothetical protein 0.0105 0.0243 0.142
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0048 0.0063 0.0076
Echinococcus granulosus neuroglian 0.0063 0.0109 0.013
Plasmodium vivax PH domain containing protein 0.0048 0.0063 0.3226
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0036 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0523 0.1549 0.1549
Schistosoma mansoni z-protein (S1r protein) 0.0523 0.1549 0.1549
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Onchocerca volvulus 0.0036 0.0027 0.0161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0322 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0048 0.0063 0.0063
Echinococcus multilocularis aurora kinase A 0.0073 0.014 0.0167
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Echinococcus granulosus exocyst complex component 2 0.0105 0.0243 0.029
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Schistosoma mansoni protein kinase 0.0036 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0049 0.0068 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0048 0.0063 0.024
Echinococcus granulosus retinal guanylyl cyclase 2 0.0036 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.1549 1
Brugia malayi Oxysterol-binding protein 0.0048 0.0063 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.2474 0.7645 0.7645
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0061 0.0104 0.6834
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Schistosoma mansoni axis inhibition protein axin 0.0523 0.1549 0.1549
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1659 0.1983
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Schistosoma mansoni axis inhibition protein axin 0.0523 0.1549 0.1549
Plasmodium falciparum protein kinase, putative 0.0049 0.0068 0.3608
Loa Loa (eye worm) hypothetical protein 0.0204 0.055 0.055
Entamoeba histolytica PH domain containing protein 0.0048 0.0063 0.024
Loa Loa (eye worm) TK/ABL protein kinase 0.0036 0.0027 0.0027
Onchocerca volvulus 0.0032 0.0015 0.0089
Schistosoma mansoni tyrosine kinase 0.0036 0.0027 0.0027
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0105 0.0243 0.1429
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0036 0.0027 0.0027
Echinococcus multilocularis heat shock protein 70 0.0036 0.0027 0.0032
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0036 0.0027 0.0032
Entamoeba histolytica hypothetical protein 0.0048 0.0063 0.024
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0048 0.0063 0.024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0027
Echinococcus multilocularis semaphorin 5B 0.0241 0.0666 0.0796
Loa Loa (eye worm) TK protein kinase 0.0036 0.0027 0.0027
Plasmodium falciparum calcium-dependent protein kinase 7 0.0061 0.0104 0.6834
Trichomonas vaginalis AGC family protein kinase 0.0073 0.014 0.0754
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0523 0.1549 0.1549
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011
Schistosoma mansoni serine/threonine RGC 0.0036 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0147
Loa Loa (eye worm) hypothetical protein 0.0067 0.0124 0.0124
Entamoeba histolytica protein kinase, putative 0.0073 0.014 0.0744
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0049 0.0068 0.3608
Schistosoma mansoni nephrin 0.0067 0.0124 0.0124
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0104 0.0519
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0027 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0036 0.0027 0.0011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.